propofol has been researched along with Obesity in 64 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "A total of 104 patients with obesity undergoing painless gastroscopy were randomly divided into group C (propofol+saline) and group S (propofol+esketamine 0." | 9.69 | Efficacy and Safety of a Subanesthetic Dose of Esketamine Combined with Propofol in Patients with Obesity Undergoing Painless Gastroscopy: A Prospective, Double-Blind, Randomized Controlled Trial. ( Fan, G; Li, Y; Liang, W; Ma, Q; Meng, F; Qin, W; Ren, Z; Wang, Y; Yin, N; Zhang, X; Zheng, L, 2023) |
| " One patient in the propofol group developed delirium compared to zero in desflurane." | 9.24 | The effect of desflurane versus propofol anesthesia on postoperative delirium in elderly obese patients undergoing total knee replacement: A randomized, controlled, double-blinded clinical trial. ( Goodman, S; Huddleston, J; Lemmens, HJ; Maloney, W; Sommer, BR; Tanaka, P, 2017) |
| "Pharmacokinetic studies in obese patients suggest that dosing of rocuronium should be based on ideal body weight (IBW)." | 9.14 | Should dosing of rocuronium in obese patients be based on ideal or corrected body weight? ( Claudius, C; Jenstrup, MT; Lund, J; Meyhoff, CS; Rasmussen, LS; Sørensen, AM; Viby-Mogensen, J, 2009) |
| "The objective of this study was to develop a pharmacokinetic (PK) model to characterize the influence of obesity on propofol PK parameters." | 9.14 | Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model. ( Anderson, BJ; Cortínez, LI; Holford, NH; Muñoz, HR; Olivares, L; Penna, A; Sepulveda, P; Struys, MM, 2010) |
| "Because of the lack of data regarding the impact of obesity on propofol pharmacokinetics in patients undergoing cardiac surgery using hypothermic cardiopulmonary bypass (CPB), the authors sought to explore propofol pharmacokinetics and develop a predictive pharmacokinetic model that characterizes and predicts propofol pharmacokinetics in this population." | 7.83 | Obesity Does Not Affect Propofol Pharmacokinetics During Hypothermic Cardiopulmonary Bypass. ( Abbassi, MM; El-Baraky, IA; Marei, TA; Sabry, NA, 2016) |
| "In this model of diet-induced obesity, a 1-hour propofol infusion yielded increased airway resistance, atelectasis, and lung inflammation, with depletion of antioxidative enzymes." | 7.83 | The Effects of Short-Term Propofol and Dexmedetomidine on Lung Mechanics, Histology, and Biological Markers in Experimental Obesity. ( Araújo, MM; Cavalcanti, VC; Fernandes, FC; Heil, LB; Maia, Lde A; Pelosi, P; Poggio, H; Rocco, PR; Samary, CS; Santos, CL; Santos, RS; Silva, PL; Trevenzoli, IH; Villela, NR, 2016) |
| "Although obesity was associated with an increased frequency of SRCs, propofol sedation can be used safely in obese patients undergoing AEPs when administered by trained professionals." | 7.77 | Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures. ( Azar, R; Cote, GA; Early, D; Edmundowicz, SA; Hall, M; Hovis, CE; Hovis, RM; Jonnalagadda, SS; Kushnir, V; Mullady, DK; Murad, F; Waldbaum, L; Wani, S, 2011) |
| "In obese patients, the incidence of postoperative nausea and vomiting (PONV) following sleeve gastrectomy under titration of total intravenous anaesthesia (TIVA) and the relevance of risk factors to indicate prophylaxis is unknown." | 6.82 | Impact of a prophylactic combination of dexamethasone-ondansetron on postoperative nausea and vomiting in obese adult patients undergoing laparoscopic sleeve gastrectomy during closed-loop propofol-remifentanil anaesthesia: A randomised double-blind place ( Bataille, A; Charmeau, A; Chazot, T; Diemunsch, P; Fischler, M; Le Guen, M; Léger, P; Lemedioni, P; Letourneulx, JF; Liu, N, 2016) |
| "A total of 104 patients with obesity undergoing painless gastroscopy were randomly divided into group C (propofol+saline) and group S (propofol+esketamine 0." | 5.69 | Efficacy and Safety of a Subanesthetic Dose of Esketamine Combined with Propofol in Patients with Obesity Undergoing Painless Gastroscopy: A Prospective, Double-Blind, Randomized Controlled Trial. ( Fan, G; Li, Y; Liang, W; Ma, Q; Meng, F; Qin, W; Ren, Z; Wang, Y; Yin, N; Zhang, X; Zheng, L, 2023) |
| "We enrolled 109 patients with diagnosis of obesity and/or obstructive sleep apnea scheduled to undergo colonoscopy under propofol general anesthesia without planned tracheal intubation." | 5.69 | Nasal continuous positive pressure versus simple face mask oxygenation for adult obese and obstructive sleep apnea patients undergoing colonoscopy under propofol-based general anesthesia without tracheal intubation: A randomized controlled trial. ( Carlson, R; Cata, JP; Cukierman, DS; Ge, PS; Ghebremichael, S; Guerra-Londono, JJ; Hagan, K; Hagberg, C; Perez, M; Raju, GS; Rhim, A, 2023) |
| "Additionally, obesity can affect pharmacodynamic properties, such as the 50% of maximal effective concentration and the effect-site equilibration rate constant (ke0)." | 5.62 | Obesity and anesthetic pharmacology: simulation of target-controlled infusion models of propofol and remifentanil. ( Kim, TK, 2021) |
| "Anesthesiologists face a dilemma in determining appropriate dosing of anesthetic drugs in obese children." | 5.38 | The effect of obesity on the ED(95) of propofol for loss of consciousness in children and adolescents. ( Abrams, S; Andropoulos, DB; Coulter-Nava, C; East, DL; Garcia, PJ; Govindan, K; Kozinetz, CA; Needham, J; Olutoye, OA; Spearman, R; Tjia, IM; Watcha, MF; Yu, X, 2012) |
| " One patient in the propofol group developed delirium compared to zero in desflurane." | 5.24 | The effect of desflurane versus propofol anesthesia on postoperative delirium in elderly obese patients undergoing total knee replacement: A randomized, controlled, double-blinded clinical trial. ( Goodman, S; Huddleston, J; Lemmens, HJ; Maloney, W; Sommer, BR; Tanaka, P, 2017) |
| "The aim of the study is to investigate the efficacy of different dosages of single bolus propofol administered on the basis of total body weight or corrected body weight for the intravenous induction of anesthesia in obese patients undergoing bariatric surgery." | 5.17 | Different dosing regimens for propofol induction in obese patients. ( Kuo, CJ; Lam, F; Lee, YJ; Liao, CC; Lin, CS; Wang, W, 2013) |
| "Twenty obese and morbidly obese children and adolescents with a mean age of 16 years (range 9-18 years), a mean total body weight (TBW) of 125 kg (range 70-184 kg) and a mean body mass index of 46 kg/m(2) (range 31-63 kg/m(2)) were available for pharmacokinetic modelling using a two-compartment pharmacokinetic model (n = 294 propofol concentration measurements)." | 5.16 | Propofol clearance in morbidly obese children and adolescents: influence of age and body size. ( Chidambaran, V; Cox, SL; Diepstraten, J; Esslinger, HR; Inge, TH; Knibbe, CA; Sadhasivam, S; Vinks, AA, 2012) |
| "Pharmacokinetic studies in obese patients suggest that dosing of rocuronium should be based on ideal body weight (IBW)." | 5.14 | Should dosing of rocuronium in obese patients be based on ideal or corrected body weight? ( Claudius, C; Jenstrup, MT; Lund, J; Meyhoff, CS; Rasmussen, LS; Sørensen, AM; Viby-Mogensen, J, 2009) |
| "The objective of this study was to develop a pharmacokinetic (PK) model to characterize the influence of obesity on propofol PK parameters." | 5.14 | Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model. ( Anderson, BJ; Cortínez, LI; Holford, NH; Muñoz, HR; Olivares, L; Penna, A; Sepulveda, P; Struys, MM, 2010) |
| "To determine the effects of induction agent and obesity on the change in functional residual capacity caused by induction of anaesthesia, we measured the change in end-expiratory respiratory volume (EERV) during induction of anaesthesia with either thiopentone or propofol." | 5.07 | Changes in end-expiratory lung volume on induction of anaesthesia with thiopentone or propofol. ( Drummond, GB; Logan, MR; Rutherford, JS, 1994) |
| " Lean body weight was proposed as a suitable weight scalar for induction of anaesthesia with propofol whereas total body weight for maintenance of anaesthesia with propofol and depolarizing muscle relaxants." | 4.98 | Peri-operative Medication Dosing in Adult Obese Elective Surgical Patients: A Systematic Review of Clinical Studies. ( Curtain, C; Hussain, Z; Mirkazemi, C; Zaidi, STR, 2018) |
| " Obesity, procedural time, and amount of propofol were the significant risk factors for atelectasis following endoscopic procedure." | 3.83 | Predictive Factors of Atelectasis Following Endoscopic Resection. ( Choe, JW; Choo, JY; Hyun, JJ; Jung, SW; Kim, SY; Koo, JS; Lee, SW; Shim, E; Song, JK; Yim, HJ, 2016) |
| "Although obesity was associated with an increased frequency of SRCs, propofol sedation can be used safely in obese patients undergoing AEPs when administered by trained professionals." | 3.77 | Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures. ( Azar, R; Cote, GA; Early, D; Edmundowicz, SA; Hall, M; Hovis, CE; Hovis, RM; Jonnalagadda, SS; Kushnir, V; Mullady, DK; Murad, F; Waldbaum, L; Wani, S, 2011) |
| " Independent predictors of PIH were high BMI, high American Society of Anesthesiology status, propofol coinduction, baseline hypotension, age and preincision duration." | 3.76 | High BMI in children as a risk factor for intraoperative hypotension. ( Blum, J; Cowan, A; Kheterpal, S; Maclean, S; Nafiu, OO; Tremper, KK, 2010) |
| "Sufentanil has been widely used to inhibit the hemodynamic responses caused by tracheal intubation." | 3.30 | Intravenous Lidocaine Decreased the Median Effective Concentration of Sufentanil for Tracheal Intubation in Obese Patients. ( He, C; Jia, D; Tu, F; Yuan, X, 2023) |
| "Pain was assessed using a numerical pain rating scale." | 3.11 | A comparison of opioid-containing anesthesia versus opioid-free anesthesia using the Cortínez-Sepúlveda model on differential cytokine responses in obese patients undergoing gastric bypass surgery: a randomized controlled trial. ( Campos-Pérez, W; Cuevas, JHM; González-Landeros, D; Martínez-López, E; Pérez-Robles, M; Pérez-Vargas, L; Ramírez-Plascencia, L; Rivera-Valdés, JJ; Sánchez-Muñoz, P, 2022) |
| " Pharmacokinetic simulation or target-controlled infusion (TCI) using models that have been adapted to patients with obesity are necessary to select appropriate dosing regimens." | 3.01 | How obesity affects the disposition of intravenous anesthetics. ( Inoue, S; Obara, S; Yoshida, K, 2023) |
| "Target-controlled infusion (TCI) systems incorporating pharmacokinetic (PK) or PK-pharmacodynamic (PK-PD) models can be used to facilitate drug administration." | 3.01 | Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia. ( Absalom, AR; Eleveld, DJ; Hannivoort, LN; Introna, M; Struys, MMRF; Touw, DJ; Vellinga, R, 2021) |
| "The primary outcome is the incidence of hypoxemia and severe hypoxemia." | 2.87 | Comparison of two supplement oxygen methods during gastroscopy with intravenous propofol anesthesia in obese patients: study protocol for a randomized controlled trial. ( Hou, HJ; Liu, FK; Liu, SH; Shao, LJ; Tian, M; Xue, FS; Zou, Y, 2018) |
| "In obese patients, the incidence of postoperative nausea and vomiting (PONV) following sleeve gastrectomy under titration of total intravenous anaesthesia (TIVA) and the relevance of risk factors to indicate prophylaxis is unknown." | 2.82 | Impact of a prophylactic combination of dexamethasone-ondansetron on postoperative nausea and vomiting in obese adult patients undergoing laparoscopic sleeve gastrectomy during closed-loop propofol-remifentanil anaesthesia: A randomised double-blind place ( Bataille, A; Charmeau, A; Chazot, T; Diemunsch, P; Fischler, M; Le Guen, M; Léger, P; Lemedioni, P; Letourneulx, JF; Liu, N, 2016) |
| "The amount of propofol-remifentanil administered by the controller is consistent with current knowledge, propofol is best dosed using TBW whereas remifentanil is best dosed using IBW." | 2.80 | Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison. ( Assenzo, V; Chazot, T; Cocard, V; Fischler, M; Journois, D; Le Guen, M; Liu, N; Lory, C; Sessler, DI, 2015) |
| "Remifentanil treatment with anesthetic induction based on the Japanese package insert might have insufficient effects in obese patients." | 2.77 | Ideal body weight-based remifentanil infusion is potentially insufficient for anesthetic induction in mildly obese patients. ( Hanada, S; Iwasaki, H; Kunisawa, T; Mitamura, S; Suzuki, A; Takahata, O, 2012) |
| " Newer pharmacokinetic models, determined from obese patient data, have been developed for propofol and remifentanil using allometric concepts and comprehensive size descriptors." | 2.58 | Advances in pharmacokinetic modeling: target controlled infusions in the obese. ( Anderson, BJ; Cortínez, LI, 2018) |
| "Propofol is an intravenous hypnotic drug that is used for induction and maintenance of sedation and general anaesthesia." | 2.58 | Clinical Pharmacokinetics and Pharmacodynamics of Propofol. ( Absalom, AR; Sahinovic, MM; Struys, MMRF, 2018) |
| "Propofol is a common hypnotic agent in anaesthesiology and intensive care medicine and for procedural sedation as well." | 2.49 | [Propofol up2date]. ( Bushuven, S; Heise, D, 2013) |
| " Pharmacokinetic parameters of muscle relaxants are minimally affected by obesity, and their dosage is based on ideal rather than TBW." | 2.43 | Anesthesia in the obese patient: pharmacokinetic considerations. ( Casati, A; Putzu, M, 2005) |
| " On the basis of pharmacokinetic-pharmacodynamic modelling, a mean blood-brain equilibration half-life of only 2." | 2.38 | Pharmacokinetic implications for the clinical use of propofol. ( Gepts, E; Kanto, J, 1989) |
| " There was no difference in delayed adverse events with 2% of the cases and 2% of the controls having delayed adverse events (P = 1." | 1.56 | Safety and Efficacy of Moderate Sedation in Super Obese Patients Undergoing Lower and Upper GI Endoscopy: a Case-Control Study. ( Benson, M; Caldis, M; Gopal, D; Hubers, J; Pfau, P, 2020) |
| "Sevoflurane was inhaled at a concentration of 5% after infusion of 1 mg/kg propofol (within 1 minute) according to lean body weight." | 1.46 | Optimum end-tidal concentration of sevoflurane to facilitate supraglottic airway device insertion with propofol at induction allowing spontaneous respiration in obese patients: A prospective observational study. ( Ding, GN; Gao, X; Miao, HH; Tian, M; Wang, HX; Wei, W; Zhang, Y, 2017) |
| "A propofol PK/PD model was developed using NONMEM and model-based simulations were performed to determine propofol dosing regimens targeting BIS of 50 ± 10." | 1.42 | Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents. ( Chidambaran, V; Cox, S; Diepstraten, J; Esslinger, H; Fukuda, T; Inge, T; Knibbe, CAJ; Sadhasivam, S; Venkatasubramanian, R; Vinks, AA, 2015) |
| "Propofol was administered and maintained at a Cp of 4." | 1.40 | Evaluation of bias in predicted and measured propofol concentrations during target-controlled infusions in obese Japanese patients: an open-label comparative study. ( Niiyama, Y; Tachibana, N; Yamakage, M, 2014) |
| "Anesthesiologists face a dilemma in determining appropriate dosing of anesthetic drugs in obese children." | 1.38 | The effect of obesity on the ED(95) of propofol for loss of consciousness in children and adolescents. ( Abrams, S; Andropoulos, DB; Coulter-Nava, C; East, DL; Garcia, PJ; Govindan, K; Kozinetz, CA; Needham, J; Olutoye, OA; Spearman, R; Tjia, IM; Watcha, MF; Yu, X, 2012) |
| "Propofol TCI was commenced at a target plasma concentration of 4microg x ml(-1) using a TCI pump." | 1.35 | [Reliability of propofol target-controlled infusion in obese patients]. ( Igarashi, T; Iwakiri, H; Nagata, O; Negishi, C; Ozaki, M, 2009) |
| "To develop a predictive pharmacokinetic model for propofol that could inform development of a dosing strategy for the obese population." | 1.35 | Encouraging the move towards predictive population models for the obese using propofol as a motivating example. ( Green, B; Kirkpatrick, CM; McLeay, SC; Morrish, GA, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.13) | 18.7374 |
| 1990's | 5 (7.81) | 18.2507 |
| 2000's | 12 (18.75) | 29.6817 |
| 2010's | 31 (48.44) | 24.3611 |
| 2020's | 14 (21.88) | 2.80 |
| Authors | Studies |
|---|---|
| Heil, LBB | 1 |
| Cruz, FF | 1 |
| Antunes, MA | 1 |
| Braga, CL | 1 |
| Agra, LC | 1 |
| Bose Leão, RM | 1 |
| Abreu, SC | 1 |
| Pelosi, P | 2 |
| Silva, PL | 2 |
| Rocco, PRM | 1 |
| Viana, MV | 1 |
| Pantet, O | 1 |
| Charrière, M | 1 |
| Favre, D | 1 |
| Piquilloud, L | 1 |
| Schneider, AG | 1 |
| Hurni, CA | 1 |
| Berger, MM | 1 |
| Doo, AR | 1 |
| Ki, MJ | 1 |
| Park, SO | 1 |
| Lee, JH | 1 |
| Ko, S | 1 |
| Campos-Pérez, W | 1 |
| Ramírez-Plascencia, L | 1 |
| Pérez-Robles, M | 1 |
| Rivera-Valdés, JJ | 1 |
| Sánchez-Muñoz, P | 1 |
| Pérez-Vargas, L | 1 |
| González-Landeros, D | 1 |
| Cuevas, JHM | 1 |
| Martínez-López, E | 1 |
| Zheng, L | 1 |
| Wang, Y | 1 |
| Ma, Q | 1 |
| Liang, W | 1 |
| Zhang, X | 1 |
| Ren, Z | 1 |
| Qin, W | 1 |
| Meng, F | 1 |
| Li, Y | 1 |
| Fan, G | 1 |
| Yin, N | 1 |
| Obara, S | 1 |
| Yoshida, K | 1 |
| Inoue, S | 1 |
| Cukierman, DS | 1 |
| Perez, M | 1 |
| Guerra-Londono, JJ | 1 |
| Carlson, R | 1 |
| Hagan, K | 1 |
| Ghebremichael, S | 1 |
| Hagberg, C | 1 |
| Ge, PS | 1 |
| Raju, GS | 1 |
| Rhim, A | 1 |
| Cata, JP | 1 |
| Jia, D | 1 |
| Yuan, X | 1 |
| He, C | 1 |
| Tu, F | 1 |
| Benson, M | 1 |
| Hubers, J | 1 |
| Caldis, M | 1 |
| Gopal, D | 1 |
| Pfau, P | 1 |
| Carron, M | 1 |
| Tessari, I | 1 |
| Linassi, F | 1 |
| Navalesi, P | 1 |
| Vellinga, R | 1 |
| Hannivoort, LN | 1 |
| Introna, M | 1 |
| Touw, DJ | 1 |
| Absalom, AR | 3 |
| Eleveld, DJ | 3 |
| Struys, MMRF | 2 |
| Kang, S | 1 |
| Lu, J | 1 |
| Zhou, HM | 1 |
| Shao, LJ | 2 |
| Liu, SH | 2 |
| Xue, FS | 2 |
| Kim, TK | 1 |
| Tanaka, P | 1 |
| Goodman, S | 1 |
| Sommer, BR | 1 |
| Maloney, W | 1 |
| Huddleston, J | 1 |
| Lemmens, HJ | 2 |
| Wang, HX | 1 |
| Miao, HH | 1 |
| Gao, X | 1 |
| Wei, W | 1 |
| Ding, GN | 1 |
| Zhang, Y | 1 |
| Tian, M | 2 |
| Cortínez, LI | 3 |
| Anderson, BJ | 2 |
| Hussain, Z | 1 |
| Curtain, C | 1 |
| Mirkazemi, C | 1 |
| Zaidi, STR | 1 |
| Sahinovic, MM | 1 |
| Ingrande, J | 1 |
| Liu, FK | 1 |
| Zou, Y | 1 |
| Hou, HJ | 1 |
| Bushuven, S | 1 |
| Heise, D | 1 |
| Lam, F | 1 |
| Liao, CC | 1 |
| Lee, YJ | 1 |
| Wang, W | 1 |
| Kuo, CJ | 1 |
| Lin, CS | 1 |
| Koehestanie, P | 1 |
| Betzel, B | 1 |
| Dogan, K | 1 |
| Berends, F | 1 |
| Janssen, I | 1 |
| Aarts, E | 1 |
| Groenen, M | 1 |
| Wahab, P | 1 |
| Li, L | 1 |
| Feng, J | 1 |
| Xie, SH | 1 |
| Geng, LC | 1 |
| Proost, JH | 1 |
| Struys, MM | 3 |
| Tachibana, N | 2 |
| Niiyama, Y | 2 |
| Yamakage, M | 2 |
| Liu, N | 2 |
| Lory, C | 1 |
| Assenzo, V | 1 |
| Cocard, V | 1 |
| Chazot, T | 2 |
| Le Guen, M | 2 |
| Sessler, DI | 1 |
| Journois, D | 1 |
| Fischler, M | 2 |
| Chidambaran, V | 2 |
| Venkatasubramanian, R | 1 |
| Sadhasivam, S | 2 |
| Esslinger, H | 1 |
| Cox, S | 1 |
| Diepstraten, J | 2 |
| Fukuda, T | 1 |
| Inge, T | 1 |
| Knibbe, CAJ | 1 |
| Vinks, AA | 2 |
| Vereecke, HE | 1 |
| Colin, P | 1 |
| Siampalioti, A | 1 |
| Karavias, D | 1 |
| Zotou, A | 1 |
| Kalfarentzos, F | 1 |
| Filos, K | 1 |
| Choe, JW | 1 |
| Jung, SW | 1 |
| Song, JK | 1 |
| Shim, E | 1 |
| Choo, JY | 1 |
| Kim, SY | 1 |
| Hyun, JJ | 1 |
| Koo, JS | 1 |
| Yim, HJ | 1 |
| Lee, SW | 1 |
| Heil, LB | 1 |
| Santos, CL | 1 |
| Santos, RS | 1 |
| Samary, CS | 1 |
| Cavalcanti, VC | 1 |
| Araújo, MM | 1 |
| Poggio, H | 1 |
| Maia, Lde A | 1 |
| Trevenzoli, IH | 1 |
| Fernandes, FC | 1 |
| Villela, NR | 1 |
| Rocco, PR | 1 |
| Bataille, A | 1 |
| Letourneulx, JF | 1 |
| Charmeau, A | 1 |
| Lemedioni, P | 1 |
| Léger, P | 1 |
| Diemunsch, P | 1 |
| El-Baraky, IA | 1 |
| Abbassi, MM | 1 |
| Marei, TA | 1 |
| Sabry, NA | 1 |
| Cabaton, J | 1 |
| Rondelet, B | 1 |
| Gergele, L | 1 |
| Besnard, C | 1 |
| Piriou, V | 1 |
| Meyhoff, CS | 2 |
| Henneberg, SW | 1 |
| Jørgensen, BG | 1 |
| Gätke, MR | 1 |
| Rasmussen, LS | 2 |
| McLeay, SC | 2 |
| Morrish, GA | 1 |
| Kirkpatrick, CM | 1 |
| Green, B | 2 |
| Lund, J | 1 |
| Jenstrup, MT | 1 |
| Claudius, C | 1 |
| Sørensen, AM | 1 |
| Viby-Mogensen, J | 1 |
| Igarashi, T | 1 |
| Nagata, O | 1 |
| Iwakiri, H | 1 |
| Negishi, C | 1 |
| Ozaki, M | 1 |
| Nafiu, OO | 1 |
| Maclean, S | 1 |
| Blum, J | 1 |
| Kheterpal, S | 1 |
| Cowan, A | 1 |
| Tremper, KK | 1 |
| Penna, A | 1 |
| Olivares, L | 1 |
| Muñoz, HR | 1 |
| Holford, NH | 1 |
| Sepulveda, P | 1 |
| Decker, SO | 1 |
| Polarz, H | 1 |
| Wani, S | 1 |
| Azar, R | 1 |
| Hovis, CE | 1 |
| Hovis, RM | 1 |
| Cote, GA | 1 |
| Hall, M | 1 |
| Waldbaum, L | 1 |
| Kushnir, V | 1 |
| Early, D | 1 |
| Mullady, DK | 1 |
| Murad, F | 1 |
| Edmundowicz, SA | 1 |
| Jonnalagadda, SS | 1 |
| Minville, V | 1 |
| Ruiz, S | 1 |
| Ferre, F | 1 |
| Gris, C | 1 |
| Girbet, MN | 1 |
| Kunisawa, T | 1 |
| Mitamura, S | 1 |
| Hanada, S | 1 |
| Suzuki, A | 1 |
| Takahata, O | 1 |
| Iwasaki, H | 1 |
| Olutoye, OA | 1 |
| Yu, X | 1 |
| Govindan, K | 1 |
| Tjia, IM | 1 |
| East, DL | 1 |
| Spearman, R | 1 |
| Garcia, PJ | 1 |
| Coulter-Nava, C | 1 |
| Needham, J | 1 |
| Abrams, S | 1 |
| Kozinetz, CA | 1 |
| Andropoulos, DB | 1 |
| Watcha, MF | 1 |
| Esslinger, HR | 1 |
| Cox, SL | 1 |
| Inge, TH | 1 |
| Knibbe, CA | 1 |
| Casati, A | 1 |
| Putzu, M | 1 |
| Cillo, JE | 1 |
| Finn, R | 1 |
| Albertin, A | 1 |
| La Colla, G | 1 |
| La Colla, L | 1 |
| Bergonzi, PC | 1 |
| Deni, F | 1 |
| Moizo, E | 1 |
| Lynch, G | 1 |
| Clinton, S | 1 |
| Siotia, A | 1 |
| Lawson, R | 1 |
| Hickey, S | 1 |
| Rutherford, JS | 1 |
| Logan, MR | 1 |
| Drummond, GB | 1 |
| Lind, L | 1 |
| Johansson, S | 1 |
| Ekman, K | 1 |
| Borges, M | 1 |
| Antognini, JF | 1 |
| Large, V | 1 |
| Reynisdottir, S | 1 |
| Eleborg, L | 1 |
| van Harmelen, V | 1 |
| Strömmer, L | 1 |
| Arner, P | 1 |
| Kakinohana, M | 1 |
| Tomiyama, H | 1 |
| Matsuda, S | 1 |
| Okuda, Y | 1 |
| Juvin, P | 1 |
| Vadam, C | 1 |
| Malek, L | 1 |
| Dupont, H | 1 |
| Marmuse, JP | 1 |
| Desmonts, JM | 2 |
| Buczko, GB | 1 |
| Servin, F | 1 |
| Trouvin, JH | 1 |
| Farinotti, R | 1 |
| Kanto, J | 1 |
| Gepts, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Comparison of Opioid-containing Anesthesia Versus Opioid-free Anesthesia Using the Cortínez-Sepúlveda Model on Differential Cytokine Responses in Patients Undergoing Gastric Bypass Surgery[NCT04854252] | 40 participants (Actual) | Interventional | 2020-11-12 | Completed | |||
| EEG to Monitor Propofol Anesthetic Depth in Infants and Toddlers[NCT05701748] | 120 participants (Anticipated) | Interventional | 2023-02-03 | Recruiting | |||
| Impact of the Automated Administration of Intravenous Anesthesia Compared to Inhalatory Anesthesia on the Speed of Emergence and the Occurrence of Postoperative Delirium[NCT03705728] | 1,000 participants (Anticipated) | Interventional | 2018-05-30 | Recruiting | |||
| Incidence of Early Postoperative Cognitive Dysfunction After Closed Loop Anesthesia vs Inhalational Anesthesia or TIVA[NCT02656901] | 132 participants (Actual) | Interventional | 2016-01-31 | Completed | |||
| Intravenous Anesthesia in Obese Patients: Propofol and Remifentanil Requirements[NCT00779844] | Phase 4 | 63 participants (Actual) | Interventional | 2008-12-31 | Terminated (stopped due to difficulty in recruiting) | ||
| A Non-Interventional Study to Develop a Pharmacokinetic - Pharmacodynamic Model for Individualized Propofol Dosing[NCT00948597] | 26 participants (Actual) | Observational | 2009-07-31 | Completed | |||
| Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Research Project[NCT00474318] | 250 participants (Actual) | Observational | 2007-03-31 | Active, not recruiting | |||
| Comparison of Propofol and Sevoflurane Anesthesia on the Quality of Recovery After Ambulatory Surgery for Anal Fistula in Obese Patients: A Prospective, Randomized, Single-blinded, Controlled Clinical Trial[NCT05529875] | 0 participants (Actual) | Interventional | 2022-10-31 | Withdrawn (stopped due to In the early stage of the research, this research was limited by the application permission of research drugs and instruments, and the research will have to be interrupted, which is extremely regrettable.) | |||
| Should we Associate Dexamethasone and Ondansetron to Closed-loop Anesthesia to Reduce the Incidence of Postoperative Nausea and Vomiting After Bariatric Surgery?[NCT01876290] | Phase 4 | 122 participants (Actual) | Interventional | 2013-05-31 | Completed | ||
| Optimizing Propofol in Obese Patients[NCT00270335] | Phase 4 | 38 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| Pharmacodynamic Trial on Rocuronium in Obese Patients[NCT00540085] | Phase 4 | 51 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| Development of Pharmacokinetic / Pharmacodynamic (pk/pd) Model of Propofol in Patients With Severe Burns[NCT03704285] | 15 participants (Actual) | Observational | 2018-09-29 | Terminated (stopped due to Outbreak COVID 19) | |||
| Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures[NCT03529461] | 56 participants (Actual) | Interventional | 2017-04-25 | Completed | |||
| The Effect of Obesity in Dexmedetomidine Metabolic Clearance[NCT02557867] | Phase 4 | 40 participants (Anticipated) | Interventional | 2015-08-31 | Active, not recruiting | ||
| The Effect of Bi-PAP at Individualized Pressures on the Postoperative Pulmonary Recovery of Morbidly Obese Patients (MOP) Undergoing Open Bariatric Surgery (OBS) and Possible Placebo Device-related Effects (Sham-Bi-PAP)[NCT03438383] | 48 participants (Actual) | Interventional | 2011-05-23 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
We used non-invasive positive pressure ventilation (NIPPV) as a first rescue maneuver in control patients who developed an oxygen desaturation less than 90 % and reported on the percentage of participants who responded. The rescue was considered successful with recovery of oxygen saturation more than 90 % within 3 minutes. (NCT03529461)
Timeframe: 3 minutes following a desaturation event < 90 %
| Intervention | Participants (Count of Participants) |
|---|---|
| Control Participants With Oxygen Desaturation < 90% | 8 |
Percentage of participants who develop a peripheral oxygen saturation event < 90%. (NCT03529461)
Timeframe: Time in seconds beginning with the start of procedure (anesthesia induction) ending with procedure completion (eyes open to verbal stimuli).
| Intervention | percentage of participants (Number) |
|---|---|
| Control | 28.6 |
| Experimental | 3.5 |
Percentage of participants who develop a peripheral oxygen saturation measured by pulse oximetry ≤ 94% (NCT03529461)
Timeframe: Time in seconds beginning with the start of procedure (anesthesia induction) ending with procedure completion (eyes open to verbal stimuli).
| Intervention | percentage of participants (Number) |
|---|---|
| Control | 57.1 |
| Experimental | 14.3 |
duration of hospitalization, calculated by discharge date minus admission date (NCT03438383)
Timeframe: From day of admission to day of discharge from the hospital
| Intervention | days (Mean) | |
|---|---|---|
| Type of OBS: gastroplasty | Type of OBS: open gastric bypass | |
| Bi-PAP | 6 | 10 |
| Sham Bi-PAP | 6 | 10 |
difference in FEV1 value measured by spirometry pre- and post-operatively (NCT03438383)
Timeframe: 24 h before surgery and at 24, 48 and 72 h post-operatively
| Intervention | Litres (Mean) | |||
|---|---|---|---|---|
| 24h before surgery | 24h post-op | 48h post-op | 72h post-op | |
| Bi-PAP | 3.1 | 1.4 | 1.7 | 1.9 |
| Sham Bi-PAP | 3.1 | 1.3 | 1.3 | 1.4 |
difference in FVC value measured by spirometry pre- and post-operatively (NCT03438383)
Timeframe: 24 h before surgery and at 24, 48 and 72 hours post-operatively
| Intervention | Litres (Mean) | |||
|---|---|---|---|---|
| 24h before surgery | 24h post-op | 48h post-op | 72h post-op | |
| Bi-PAP | 3.5 | 1.6 | 2.0 | 2.3 |
| Sham Bi-PAP | 3.4 | 1.3 | 1.5 | 1.9 |
occurrence of atelectasis as defined by chest X-ray (CXR) post-operatively with CXR before surgery as baseline (NCT03438383)
Timeframe: At 24, 48 and 72 hours post-operatively
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| 24h post-op | 48h list-op | 72h post-op | |
| Bi-PAP | 0 | 0 | 0 |
| Sham Bi-PAP | 3 | 3 | 3 |
occurrence of hypoxemia, considered as SpO2<90%, post-operatively (NCT03438383)
Timeframe: At 24, 48 and 72 hours post-operatively
| Intervention | Participants (Count of Participants) | ||
|---|---|---|---|
| 24h post-op | 48h post-op | 72h post-op | |
| Bi-PAP | 0 | 0 | 0 |
| Sham Bi-PAP | 5 | 0 | 0 |
difference in PEFR value measured by spirometry pre- and post-operatively (NCT03438383)
Timeframe: 24 h before surgery and at 24, 48 and 72 hours post-operatively
| Intervention | Litres/minute (Mean) | |||
|---|---|---|---|---|
| 24h before surgery | 24h post-op | 48h post-op | 72h post-op | |
| Bi-PAP | 325.3 | 137.4 | 195.7 | 247.5 |
| Sham Bi-PAP | 376.9 | 146.9 | 166.0 | 190.1 |
Intensity of pain was assessed post-operatively by Numerical Rating Scale (NRS) (0-10, 0=no pain, 10=worst pain imaginable) (NCT03438383)
Timeframe: right before spirometry, at 24, 48 and 72 h post-operatively
| Intervention | score on a scale (Mean) | ||
|---|---|---|---|
| 24h post-op | 48h post-op | 72h post-op | |
| Bi-PAP | 6.5 | 5.3 | 3.5 |
| Sham Bi-PAP | 6.5 | 4.5 | 3.3 |
difference in SpO2 value measured by spirometry pre- and post-operatively (NCT03438383)
Timeframe: 24 h before surgery and at 24, 48 and 72 hours post-operatively
| Intervention | percentage of SpO2 (Mean) | |||
|---|---|---|---|---|
| 24h before surgery | 24h post-op | 48h post-op | 72h post-op | |
| Bi-PAP | 96.9 | 92.6 | 95.2 | 96.8 |
| Sham Bi-PAP | 96.9 | 91.6 | 92.4 | 92.5 |
9 reviews available for propofol and Obesity
| Article | Year |
|---|---|
How obesity affects the disposition of intravenous anesthetics.
Topics: Anesthetics, Intravenous; Humans; Obesity; Obesity, Morbid; Propofol; Remifentanil | 2023 |
Desflurane versus propofol for general anesthesia maintenance in obese patients: A pilot meta-analysis.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Inhalation; A | 2021 |
Advances in pharmacokinetic modeling: target controlled infusions in the obese.
Topics: Anesthetics, Intravenous; Body Composition; Body Mass Index; Body Weight; Humans; Obesity; Patient-S | 2018 |
Peri-operative Medication Dosing in Adult Obese Elective Surgical Patients: A Systematic Review of Clinical Studies.
Topics: Analgesics; Anticoagulants; Body Mass Index; Body Weight; Clinical Trials as Topic; Elective Surgica | 2018 |
Clinical Pharmacokinetics and Pharmacodynamics of Propofol.
Topics: Adult; Anesthetics, Intravenous; Animals; Child; Dose-Response Relationship, Drug; Drug Interactions | 2018 |
[Propofol up2date].
Topics: Adult; Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Conscious Sedation; Critical | 2013 |
Anesthesia in the obese patient: pharmacokinetic considerations.
Topics: Analgesics, Opioid; Anesthetics; Benzodiazepines; Cardiovascular Physiological Phenomena; Humans; Mu | 2005 |
Anesthesia in the obese patient: pharmacokinetic considerations.
Topics: Analgesics, Opioid; Anesthetics; Benzodiazepines; Cardiovascular Physiological Phenomena; Humans; Mu | 2005 |
Anesthesia in the obese patient: pharmacokinetic considerations.
Topics: Analgesics, Opioid; Anesthetics; Benzodiazepines; Cardiovascular Physiological Phenomena; Humans; Mu | 2005 |
Anesthesia in the obese patient: pharmacokinetic considerations.
Topics: Analgesics, Opioid; Anesthetics; Benzodiazepines; Cardiovascular Physiological Phenomena; Humans; Mu | 2005 |
Anesthesia in the obese patient: pharmacokinetic considerations.
Topics: Analgesics, Opioid; Anesthetics; Benzodiazepines; Cardiovascular Physiological Phenomena; Humans; Mu | 2005 |
Anesthesia in the obese patient: pharmacokinetic considerations.
Topics: Analgesics, Opioid; Anesthetics; Benzodiazepines; Cardiovascular Physiological Phenomena; Humans; Mu | 2005 |
Anesthesia in the obese patient: pharmacokinetic considerations.
Topics: Analgesics, Opioid; Anesthetics; Benzodiazepines; Cardiovascular Physiological Phenomena; Humans; Mu | 2005 |
Anesthesia in the obese patient: pharmacokinetic considerations.
Topics: Analgesics, Opioid; Anesthetics; Benzodiazepines; Cardiovascular Physiological Phenomena; Humans; Mu | 2005 |
Anesthesia in the obese patient: pharmacokinetic considerations.
Topics: Analgesics, Opioid; Anesthetics; Benzodiazepines; Cardiovascular Physiological Phenomena; Humans; Mu | 2005 |
Sedation in critically ill patients: a review.
Topics: Adult; Age Factors; Aged; Analgesics; Critical Illness; Electroencephalography; Humans; Hypnotics an | 2001 |
Pharmacokinetic implications for the clinical use of propofol.
Topics: Adult; Aged; Aging; Anesthetics; Blood Proteins; Child; Child, Preschool; Dose-Response Relationship | 1989 |
20 trials available for propofol and Obesity
| Article | Year |
|---|---|
A comparison of opioid-containing anesthesia versus opioid-free anesthesia using the Cortínez-Sepúlveda model on differential cytokine responses in obese patients undergoing gastric bypass surgery: a randomized controlled trial.
Topics: Adult; Analgesics, Opioid; Anesthesia; Cross-Sectional Studies; Cytokines; Female; Fentanyl; Gastric | 2022 |
Efficacy and Safety of a Subanesthetic Dose of Esketamine Combined with Propofol in Patients with Obesity Undergoing Painless Gastroscopy: A Prospective, Double-Blind, Randomized Controlled Trial.
Topics: Gastroscopy; Humans; Hypoxia; Obesity; Propofol; Prospective Studies | 2023 |
Nasal continuous positive pressure versus simple face mask oxygenation for adult obese and obstructive sleep apnea patients undergoing colonoscopy under propofol-based general anesthesia without tracheal intubation: A randomized controlled trial.
Topics: Adult; Anesthesia, General; Colonoscopy; Continuous Positive Airway Pressure; Humans; Intubation, In | 2023 |
Intravenous Lidocaine Decreased the Median Effective Concentration of Sufentanil for Tracheal Intubation in Obese Patients.
Topics: Humans; Intubation, Intratracheal; Lidocaine; Obesity; Propofol; Saline Solution; Sufentanil | 2023 |
Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia.
Topics: Adolescent; Adult; Age Factors; Aged; Anesthesia, General; Anesthetics, Intravenous; Body Weight; Ch | 2021 |
Anesthetic strategy for obese patients during gastroscopy: deep sedation or conscious sedation? A prospective randomized controlled trial.
Topics: Anesthetics; Conscious Sedation; Deep Sedation; Gastroscopy; Humans; Hypnotics and Sedatives; Obesit | 2021 |
The effect of desflurane versus propofol anesthesia on postoperative delirium in elderly obese patients undergoing total knee replacement: A randomized, controlled, double-blinded clinical trial.
Topics: Aged; Anesthesia, General; Arthroplasty, Replacement, Knee; Cognitive Dysfunction; Delirium; Desflur | 2017 |
Comparison of two supplement oxygen methods during gastroscopy with intravenous propofol anesthesia in obese patients: study protocol for a randomized controlled trial.
Topics: Anesthesia, Intravenous; Gastroscopy; Humans; Hypoxia; Obesity; Oxygen; Propofol; Randomized Control | 2018 |
Different dosing regimens for propofol induction in obese patients.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Body Weight; Electroencephalography; Female; Hemodynami | 2013 |
The feasibility of delivering a duodenal-jejunal bypass liner (EndoBarrier) endoscopically with patients under conscious sedation.
Topics: Body Mass Index; Conscious Sedation; Diabetes Mellitus, Type 2; Duodenum; Endoscopy; Female; Humans; | 2014 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Anesthesia management for the super obese: is sevoflurane superior to propofol as a sole anesthetic agent? A double-blind randomized controlled trial.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Bariatric Surgery; Double-Blind Method; Fe | 2015 |
Impact of a prophylactic combination of dexamethasone-ondansetron on postoperative nausea and vomiting in obese adult patients undergoing laparoscopic sleeve gastrectomy during closed-loop propofol-remifentanil anaesthesia: A randomised double-blind place
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Dexamethasone; Double-Blind Method; Female; Ga | 2016 |
Depth of anaesthesia monitoring in obese patients: a randomized study of propofol-remifentanil.
Topics: Adult; Aged; Algorithms; Anesthesia; Female; Humans; Hysterectomy; Middle Aged; Obesity; Piperidines | 2009 |
Should dosing of rocuronium in obese patients be based on ideal or corrected body weight?
Topics: Adult; Androstanols; Anesthesia Recovery Period; Anesthetics, Intravenous; Body Mass Index; Body Wei | 2009 |
Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Anthropometry; Bariatric Surgery; Body Mas | 2010 |
Ideal body weight-based remifentanil infusion is potentially insufficient for anesthetic induction in mildly obese patients.
Topics: Adult; Androstanols; Anesthetics, Intravenous; Female; Humans; Ideal Body Weight; Infusions, Intrave | 2012 |
Propofol clearance in morbidly obese children and adolescents: influence of age and body size.
Topics: Adolescent; Age Factors; Anesthetics, Intravenous; Body Weight; Child; Dose-Response Relationship, D | 2012 |
Propofol clearance in morbidly obese children and adolescents: influence of age and body size.
Topics: Adolescent; Age Factors; Anesthetics, Intravenous; Body Weight; Child; Dose-Response Relationship, D | 2012 |
Propofol clearance in morbidly obese children and adolescents: influence of age and body size.
Topics: Adolescent; Age Factors; Anesthetics, Intravenous; Body Weight; Child; Dose-Response Relationship, D | 2012 |
Propofol clearance in morbidly obese children and adolescents: influence of age and body size.
Topics: Adolescent; Age Factors; Anesthetics, Intravenous; Body Weight; Child; Dose-Response Relationship, D | 2012 |
Changes in end-expiratory lung volume on induction of anaesthesia with thiopentone or propofol.
Topics: Adult; Anesthesia, General; Female; Functional Residual Capacity; Humans; Masks; Obesity; Propofol; | 1994 |
Postoperative recovery after desflurane, propofol, or isoflurane anesthesia among morbidly obese patients: a prospective, randomized study.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inh | 2000 |
35 other studies available for propofol and Obesity
| Article | Year |
|---|---|
Effects of propofol and its formulation components on macrophages and neutrophils in obese and lean animals.
Topics: Adipose Tissue; Anesthetics, Intravenous; Animals; Chemotaxis, Leukocyte; Excipients; Glycerol; Inte | 2021 |
Specific nutrition and metabolic characteristics of critically ill patients with persistent COVID-19.
Topics: Aged; COVID-19; Critical Illness; Energy Intake; Female; Humans; Intensive Care Units; Male; Middle | 2022 |
Influence of body fatness on propofol requirements for loss of consciousness in target-controlled infusion: A STROBE-compliant study.
Topics: Adipose Tissue; Anesthetics, Intravenous; Female; Humans; Male; Obesity; Propofol; Unconsciousness | 2022 |
Safety and Efficacy of Moderate Sedation in Super Obese Patients Undergoing Lower and Upper GI Endoscopy: a Case-Control Study.
Topics: Case-Control Studies; Conscious Sedation; Endoscopy; Humans; Obesity; Obesity, Morbid; Propofol | 2020 |
Sedation strategy for gastroscopy in obese patients.
Topics: Anesthesia; Conscious Sedation; Gastroscopy; Humans; Obesity; Propofol | 2022 |
Obesity and anesthetic pharmacology: simulation of target-controlled infusion models of propofol and remifentanil.
Topics: Anesthetics, Intravenous; Humans; Infusions, Intravenous; Obesity; Propofol; Remifentanil | 2021 |
Optimum end-tidal concentration of sevoflurane to facilitate supraglottic airway device insertion with propofol at induction allowing spontaneous respiration in obese patients: A prospective observational study.
Topics: Adult; Airway Management; Anesthetics, Inhalation; Anesthetics, Intravenous; Bariatric Surgery; Dose | 2017 |
Target-Controlled Infusion: Not a One-Sized-Fits-All Answer to Drug Administration.
Topics: Anesthetics, Intravenous; Humans; Obesity; Propofol | 2018 |
A chin-lift mask produces a patent airway more effectively than an oropharyngeal airway using the EC-clamp technique in obese patients.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Atracurium; Chin; Cholecystectomy; Cholecystit | 2014 |
A general purpose pharmacokinetic model for propofol.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Algorithms; Anesthesia, Intravenous; | 2014 |
Evaluation of bias in predicted and measured propofol concentrations during target-controlled infusions in obese Japanese patients: an open-label comparative study.
Topics: Adult; Anesthetics, Intravenous; Bias; Female; Humans; Japan; Male; Middle Aged; Obesity; Predictive | 2014 |
Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents.
Topics: Adolescent; Anesthetics, Intravenous; Child; Dose-Response Relationship, Drug; Drug Dosage Calculati | 2015 |
Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents.
Topics: Adolescent; Anesthetics, Intravenous; Child; Dose-Response Relationship, Drug; Drug Dosage Calculati | 2015 |
Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents.
Topics: Adolescent; Anesthetics, Intravenous; Child; Dose-Response Relationship, Drug; Drug Dosage Calculati | 2015 |
Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents.
Topics: Adolescent; Anesthetics, Intravenous; Child; Dose-Response Relationship, Drug; Drug Dosage Calculati | 2015 |
Performance of the Eleveld pharmacokinetic model to titrate propofol in an obese Japanese patient population.
Topics: Anesthetics, Intravenous; Female; Humans; Male; Obesity; Propofol | 2016 |
Reply to: performance of the Eleveld pharmacokinetic model to titrate propofol in an obese Japanese patient population.
Topics: Anesthetics, Intravenous; Female; Humans; Male; Obesity; Propofol | 2016 |
Predictive Factors of Atelectasis Following Endoscopic Resection.
Topics: Aged; Chi-Square Distribution; Comorbidity; Deep Sedation; Endoscopy, Gastrointestinal; Female; Gast | 2016 |
The Effects of Short-Term Propofol and Dexmedetomidine on Lung Mechanics, Histology, and Biological Markers in Experimental Obesity.
Topics: Animals; Biomarkers; Dexmedetomidine; Lung; Male; Obesity; Propofol; Rats; Rats, Wistar; Respiration | 2016 |
Obesity Does Not Affect Propofol Pharmacokinetics During Hypothermic Cardiopulmonary Bypass.
Topics: Adult; Age Factors; Anesthetics, Intravenous; Anthropometry; Blood Specimen Collection; Cardiac Surg | 2016 |
[Tako-Tsubo syndrome after anaphylaxis caused by succinylcholine during general anaesthesia].
Topics: Anaphylaxis; Anesthesia, General; Anesthesia, Intravenous; Diabetes Mellitus, Type 2; Female; Gastro | 2008 |
Encouraging the move towards predictive population models for the obese using propofol as a motivating example.
Topics: Adolescent; Adult; Analysis of Variance; Anesthetics, Intravenous; Body Weight; Computer Simulation; | 2009 |
[Reliability of propofol target-controlled infusion in obese patients].
Topics: Adult; Anesthesia, General; Anesthetics; Humans; Infusions, Intravenous; Middle Aged; Obesity; Propo | 2009 |
High BMI in children as a risk factor for intraoperative hypotension.
Topics: Adolescent; Age Factors; Anesthesia, General; Anesthetics, Intravenous; Body Mass Index; Child; Chil | 2010 |
Anesthetizing the obese.
Topics: Anesthesia; Body Weight; Dose-Response Relationship, Drug; Humans; Metabolic Clearance Rate; Obesity | 2011 |
[Silexan and narcosis : case report and possibilities of preoperative and perioperative management].
Topics: Adolescent; Anesthesia, Intravenous; Anesthetics; Anesthetics, Intravenous; Arachnoid Cysts; Cerebel | 2011 |
Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures.
Topics: Aged; Anesthetics, Intravenous; Body Mass Index; Conscious Sedation; Digestive System Diseases; Endo | 2011 |
[Medication error: account the shape but the context too].
Topics: Adult; Anesthesia, Epidural; Anesthesia, General; Anesthesia, Obstetrical; Anesthetics, Intravenous; | 2012 |
The effect of obesity on the ED(95) of propofol for loss of consciousness in children and adolescents.
Topics: Adolescent; Age Factors; Anesthetics, Intravenous; Body Mass Index; Child; Child, Preschool; Conscio | 2012 |
Correlation and comparison of body mass index on hemodynamics in hypertensive and normotensive patients undergoing intravenous sedation.
Topics: Adult; Anesthesia, Dental; Anesthetics, Intravenous; Blood Pressure; Body Mass Index; Conscious Seda | 2006 |
Effect site concentrations of remifentanil maintaining cardiovascular homeostasis in response to surgical stimuli during bispectral index guided propofol anestesia in seriously obese patients.
Topics: Adult; Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Mass Index; Electroencephalogra | 2006 |
Anaesthesia and Alström's syndrome.
Topics: Adult; Anesthesia; Anesthetics, Intravenous; Atrial Fibrillation; Blindness; Deafness; Diabetes Mell | 2007 |
Puncture of the laryngeal mask airway cuff.
Topics: Airway Obstruction; Anesthesia, Intravenous; Fentanyl; Humans; Laryngeal Masks; Male; Obesity; Propo | 1994 |
The influence of obesity and fat distribution on induction and maintenance doses of propofol. (Short communication).
Topics: Adipose Tissue; Adult; Body Composition; Female; Humans; Middle Aged; Obesity; Propofol | 1993 |
Anaesthesia for Mauriac's syndrome.
Topics: Adolescent; Anesthesia, General; Corneal Transplantation; Diabetes Mellitus; Diabetes Mellitus, Type | 1993 |
Lipolysis in human fat cells obtained under local and general anesthesia.
Topics: Abdomen; Adenylyl Cyclases; Adipocytes; Adrenergic beta-Agonists; Adult; Anesthesia, General; Anesth | 1997 |
[Target-controlled propofol infusion for general anesthesia in three obese patients].
Topics: Adult; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Cholelithiasis; Femal | 2000 |
[Pharmacokinetics of propofol in obesity].
Topics: Adult; Anesthetics; Humans; Middle Aged; Obesity; Propofol | 1989 |