propofol has been researched along with Nerve Degeneration in 12 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Two animal models of TLE--amygdala kindling and pilocarpine-induced status epilepticus (Pilo-SE)--were tested." | 3.75 | Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. ( Leung, LS; Long, JJ; Luo, T; McMurran, TJ; Shen, B; Stewart, L, 2009) |
| "Propofol (100 mg/kg) was given to 7-day-old (P7) Sprague Dawley pups." | 1.48 | Hypoxic preconditioning reduces propofol-induced neuroapoptosis via regulation of Bcl-2 and Bax and downregulation of activated caspase-3 in the hippocampus of neonatal rats. ( Chen, J; Liang, Y; Lv, J; Tu, Y; Xie, Y, 2018) |
| "Propofol may cause neuronal death in newborn rat brains, which is prevented by low-dose rEPO but not high-dose rEPO." | 1.36 | Dose-dependent effects of erythropoietin in propofol anesthetized neonatal rats. ( Bercker, S; Bittigau, P; Bührer, C; Felderhoff-Müser, U; Kerner, T; Kny, J; Schmidt, M; Sifringer, M; Zacharias, R, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 4 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, J | 1 |
| Liang, Y | 1 |
| Tu, Y | 1 |
| Chen, J | 1 |
| Xie, Y | 1 |
| Yang, B | 1 |
| Liang, G | 1 |
| Khojasteh, S | 1 |
| Wu, Z | 1 |
| Yang, W | 1 |
| Joseph, D | 1 |
| Wei, H | 1 |
| Long, JJ | 1 |
| Shen, B | 1 |
| Luo, T | 1 |
| Stewart, L | 1 |
| McMurran, TJ | 1 |
| Leung, LS | 1 |
| Bercker, S | 2 |
| Bert, B | 1 |
| Bittigau, P | 2 |
| Felderhoff-Müser, U | 2 |
| Bührer, C | 2 |
| Ikonomidou, C | 1 |
| Weise, M | 1 |
| Kaisers, UX | 1 |
| Kerner, T | 2 |
| Zhang, H | 1 |
| Mei, X | 1 |
| Wang, W | 1 |
| Sun, X | 1 |
| Zacharias, R | 1 |
| Schmidt, M | 1 |
| Kny, J | 1 |
| Sifringer, M | 1 |
| Milanovic, D | 1 |
| Popic, J | 1 |
| Pesic, V | 1 |
| Loncarevic-Vasiljkovic, N | 1 |
| Kanazir, S | 1 |
| Jevtovic-Todorovic, V | 3 |
| Ruzdijic, S | 1 |
| Baxter, MG | 1 |
| Murphy, KL | 1 |
| Crosby, G | 1 |
| Culley, DJ | 1 |
| Hans, P | 1 |
| Bonhomme, V | 1 |
| Collette, J | 1 |
| Albert, A | 1 |
| Moonen, G | 1 |
| Kirby, CO | 1 |
| Olney, JW | 2 |
| Yamaguchi, S | 1 |
| Midorikawa, Y | 1 |
| Okuda, Y | 1 |
| Kitajima, T | 1 |
| Wozniak, DF | 1 |
| Powell, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Erythropoietin and Hypothermia on Management of Neonatal Hypoxic Ischemic Encephalopathy[NCT03163589] | Phase 3 | 40 participants (Anticipated) | Interventional | 2017-12-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for propofol and Nerve Degeneration
| Article | Year |
|---|---|
Blocking conversion of GABAergic inhibition as a potential mechanism of propofol-mediated brain protection following resuscitation.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Cardiopulmonary Resuscitation; gamma-Aminobutyric | 2009 |
11 other studies available for propofol and Nerve Degeneration
| Article | Year |
|---|---|
Hypoxic preconditioning reduces propofol-induced neuroapoptosis via regulation of Bcl-2 and Bax and downregulation of activated caspase-3 in the hippocampus of neonatal rats.
Topics: Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Female; Hippocampus; Is | 2018 |
Comparison of neurodegeneration and cognitive impairment in neonatal mice exposed to propofol or isoflurane.
Topics: Administration, Inhalation; Anesthetics; Animals; Animals, Newborn; Apoptosis; Brain Damage, Chronic | 2014 |
Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics.
Topics: Anesthetics, General; Animals; Brain; Consciousness Disorders; Convulsants; Disease Models, Animal; | 2009 |
Neurodegeneration in newborn rats following propofol and sevoflurane anesthesia.
Topics: Analysis of Variance; Anesthetics; Animals; Animals, Newborn; Blood Gas Analysis; Cues; Dose-Respons | 2009 |
Dose-dependent effects of erythropoietin in propofol anesthetized neonatal rats.
Topics: Age Factors; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Drug Interactions; Erythro | 2010 |
Regional and temporal profiles of calpain and caspase-3 activities in postnatal rat brain following repeated propofol administration.
Topics: Anesthetics, Intravenous; Animals; Blotting, Western; Brain; Calpain; Caspase 3; Immunohistochemistr | 2010 |
Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Behavior, Animal; Denervation; Hippocamp | 2008 |
Propofol protects cultured rat hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; | 1994 |
Isoflurane and propofol block neurotoxicity caused by MK-801 in the rat posterior cingulate/retrosplenial cortex.
Topics: Anesthetics, Inhalation; Animals; Brain Damage, Chronic; Dizocilpine Maleate; Excitatory Amino Acid | 1997 |
Propofol prevents delayed neuronal death following transient forebrain ischemia in gerbils.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Atrophy; Carotid Artery, Common; Cell Death | 1999 |
Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex.
Topics: Anesthetics, Intravenous; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Inter | 2001 |