Page last updated: 2024-11-03

propofol and Myasthenia Gravis

propofol has been researched along with Myasthenia Gravis in 29 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Myasthenia Gravis: A disorder of neuromuscular transmission characterized by fatigable weakness of cranial and skeletal muscles with elevated titers of ACETYLCHOLINE RECEPTORS or muscle-specific receptor tyrosine kinase (MuSK) autoantibodies. Clinical manifestations may include ocular muscle weakness (fluctuating, asymmetric, external ophthalmoplegia; diplopia; ptosis; and weakness of eye closure) and extraocular fatigable weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles (ocular myasthenia). THYMOMA is commonly associated with this condition.

Research Excerpts

ExcerptRelevanceReference
"We report 11 cases of thymectomy for myasthenia gravis using propofol and thoracic epidural anesthesia."7.71[Propofol anesthesia combined with thoracic epidural anesthesia for thymectomy for myasthenia gravis--a report of eleven cases]. ( Abe, S; Hikawa, Y; Kaneko, T; Maeda, M; Saitoh, Y; Takeuchi, C; Yasuda, K, 2001)
"We report a case of trans-sternal thymectomy for myasthenia gravis using a non relaxant, total intravenous technique with propofol and remifentanil."7.70Remifentanil and propofol total intravenous anaesthesia for thymectomy in myasthenia gravis. ( Hall, R; Lorimer, M, 1998)
"We describe the effect of repeated suxamethonium doses during propofol-fentanyl-N2O/O2 anaesthesia in a 29-year-old woman with active myasthenia gravis receiving chronic pyridostigmine therapy."7.69Response to suxamethonium during propofol-fentanyl-N2O/O2 anaesthesia in a patient with active myasthenia gravis receiving long-term anticholinesterase therapy. ( Booij, LH; Robertson, EN; Vanlinthout, LE, 1994)
"Experience with the use of propofol for induction and maintenance of anesthesia in patients with myasthenia gravis is limited in the literature."7.69Propofol anesthesia in a patient with myasthenia gravis--a case report. ( Chen, HM; Chen, MF; Lin, CC; Shyr, MH; Tan, PP, 1996)
"Experience with the use of propofol for induction and maintenance of anesthesia in patients with myasthenia gravis is limited."7.68Total intravenous anesthesia with propofol for thymectomy in a patient with myasthenia gravis. ( Roelofse, JA; Roth, PJ, 1993)
"Although several studies of the use of desflurane in anesthesia have revealed many desirable qualities, there are no data on the use and effects especially on the neuromuscular function of desflurane on myasthenia gravis (MG) patients."5.14The use of desflurane or propofol in combination with remifentanil in myasthenic patients undergoing a video-assisted thoracoscopic-extended thymectomy. ( Benigni, A; Bortolotti, G; Carrara, B; Giardini, D; Gritti, P; Khotcholava, M; Lanterna, LA; Sonzogni, V, 2009)
" We report the successful use of intra-operative train of four ratio monitoring and Sugammadex to reverse rocuronium induced neuromuscular blockade in an elderly octagenarian with Myaesthenia Gravis undergoing an emergency laporotomy."3.85Use of Sugammadex in an octagenerian with Myaesthenia Gravis undergoing emergency laporotomy. ( Dharmarajah, A; Shah, D, 2017)
"We report 11 cases of thymectomy for myasthenia gravis using propofol and thoracic epidural anesthesia."3.71[Propofol anesthesia combined with thoracic epidural anesthesia for thymectomy for myasthenia gravis--a report of eleven cases]. ( Abe, S; Hikawa, Y; Kaneko, T; Maeda, M; Saitoh, Y; Takeuchi, C; Yasuda, K, 2001)
"We report a case of trans-sternal thymectomy for myasthenia gravis using a non relaxant, total intravenous technique with propofol and remifentanil."3.70Remifentanil and propofol total intravenous anaesthesia for thymectomy in myasthenia gravis. ( Hall, R; Lorimer, M, 1998)
"We describe the effect of repeated suxamethonium doses during propofol-fentanyl-N2O/O2 anaesthesia in a 29-year-old woman with active myasthenia gravis receiving chronic pyridostigmine therapy."3.69Response to suxamethonium during propofol-fentanyl-N2O/O2 anaesthesia in a patient with active myasthenia gravis receiving long-term anticholinesterase therapy. ( Booij, LH; Robertson, EN; Vanlinthout, LE, 1994)
"Two patients with myasthenia gravis were ventilated postoperatively using propofol and piritramide for analgosedation."3.69[A new method of pain sedation following thymectomy in myasthenia gravis. 2 cases]. ( Engler, J; Hiotakis, K, 1994)
"Experience with the use of propofol for induction and maintenance of anesthesia in patients with myasthenia gravis is limited in the literature."3.69Propofol anesthesia in a patient with myasthenia gravis--a case report. ( Chen, HM; Chen, MF; Lin, CC; Shyr, MH; Tan, PP, 1996)
"Experience with the use of propofol for induction and maintenance of anesthesia in patients with myasthenia gravis is limited."3.68Total intravenous anesthesia with propofol for thymectomy in a patient with myasthenia gravis. ( Roelofse, JA; Roth, PJ, 1993)
"Propofol was discontinued when the sternum was approximated."2.74Bispectral index-monitored anesthesia technique for transsternal thymectomy. ( Maddali, MM; Matreja, PV; Zachariah, M, 2009)
"Myasthenia gravis is a chronic autoimmune disease characterized by a reduction of postsynaptic nicotinic acetylcholine receptors at the neuromuscular junction."1.35Laryngeal Mask Airway insertion with total intravenous anesthesia for transsternal thymectomy in patients with myasthenia gravis: report of 5 cases. ( Arslan, G; Bilen, A; Bozdogan, N; Kilic, D; Sener, M, 2008)
"Juvenile myasthenia gravis is the acquired form of the disease in children and presents with ocular signs, fatigability, weakness and bulbar problems."1.34A combination of total intravenous anesthesia and thoracic epidural for thymectomy in juvenile myasthenia gravis. ( Bagshaw, O, 2007)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (34.48)18.2507
2000's15 (51.72)29.6817
2010's3 (10.34)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Hien, VV1
Tu, NH1
Thu, ND1
Akatsu, M1
Ikegami, Y1
Tase, C1
Nishikawa, K1
Shah, D1
Dharmarajah, A1
Nauphal, M1
Baraka, A1
Gritti, P1
Carrara, B1
Khotcholava, M1
Bortolotti, G1
Giardini, D1
Lanterna, LA1
Benigni, A1
Sonzogni, V1
Maddali, MM1
Matreja, PV1
Zachariah, M1
Tagawa, T1
Sakuraba, S1
Okuda, M1
Abe, N1
Kunisawa, T1
Sasakawa, T1
Takahata, O1
Iwasaki, H2
Hepağuşlar, H1
Oztekin, S1
Capar, E1
Elar, Z1
Fodale, V1
Pratico', C1
Piana, F1
Caruso, A1
Lucanto, T1
Coniglio, S1
Santamaria, LB1
Bouaggad, A1
Bouderka, MA1
Abassi, O1
Mekis, D1
Kamenik, M1
El-Dawlatly, AA1
Al Kattan, K1
Hajjar, W1
Essa, M1
Delvi, B1
Khoja, A1
Ng, JM1
Bagshaw, O1
Narimatsu, E1
Munemura, Y1
Kawamata, M1
Imaizumi, H1
Namiki, A1
Sener, M1
Bilen, A1
Bozdogan, N1
Kilic, D1
Arslan, G1
Roelofse, JA1
Roth, PJ1
Vanlinthout, LE1
Robertson, EN1
Booij, LH1
Engler, J1
Hiotakis, K1
Khan, RM1
Maroof, M1
Lin, CC1
Chen, MF1
Chen, HM1
Tan, PP1
Shyr, MH1
Quintana-Villamandos, B1
Garutti-Martínez, I1
Clar de Alba, B1
Fernández-López, R1
Ferrando-Jordá, A1
Olmedilla-Arnal, L1
Lorimer, M1
Hall, R1
Ishimura, H1
Sata, T1
Matsumoto, T1
Takizuka, A1
Shigematsu, A1
Hamaguchi, S1
Kitajima, T1
Yasuda, S1
Itoh, H1
Shibata, K1
Abe, S1
Takeuchi, C1
Kaneko, T1
Maeda, M1
Saitoh, Y1
Hikawa, Y1
Yasuda, K1
De Grazia, R1
Belluco, A1
Chiarini, L1
Nani, R1

Reviews

1 review available for propofol and Myasthenia Gravis

ArticleYear
[Anesthesia with continuous infusion of propofol in myasthenic patients].
    Minerva anestesiologica, 1992, Volume: 58, Issue:3

    Topics: Adult; Anesthesia, Intravenous; Humans; Infusions, Intravenous; Male; Middle Aged; Myasthenia Gravis

1992

Trials

3 trials available for propofol and Myasthenia Gravis

ArticleYear
The use of desflurane or propofol in combination with remifentanil in myasthenic patients undergoing a video-assisted thoracoscopic-extended thymectomy.
    Acta anaesthesiologica Scandinavica, 2009, Volume: 53, Issue:3

    Topics: Adolescent; Adult; Anesthesia; Desflurane; Drug Combinations; Female; Humans; Isoflurane; Male; Midd

2009
Bispectral index-monitored anesthesia technique for transsternal thymectomy.
    Asian cardiovascular & thoracic annals, 2009, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intravenous; Electro

2009
Total intravenous anaesthesia with propofol for myasthenic patients.
    European journal of anaesthesiology, 2005, Volume: 22, Issue:5

    Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Fentanyl; Humans; Intubation, Intratracheal; Lary

2005

Other Studies

25 other studies available for propofol and Myasthenia Gravis

ArticleYear
Propofol TCI or sevoflurane anesthesia without muscle relaxant for thoracoscopic thymectomy in myasthenia gravis patients: a prospective, observational study.
    BMC anesthesiology, 2023, 10-21, Volume: 23, Issue:1

    Topics: Anesthesia, General; Anesthetics, Intravenous; Humans; Methyl Ethers; Muscles; Myasthenia Gravis; Pr

2023
Anesthetic Management of a Patient With Antimuscle-Specific Kinase Antibody-Positive Myasthenia Gravis Undergoing an Open Cholecystectomy: A Case Report.
    A & A case reports, 2017, Mar-15, Volume: 8, Issue:6

    Topics: Analgesia, Epidural; Anesthesia, General; Anesthetics, Intravenous; Autoantibodies; Cholecystectomy;

2017
Use of Sugammadex in an octagenerian with Myaesthenia Gravis undergoing emergency laporotomy.
    Journal of clinical anesthesia, 2017, Volume: 37

    Topics: Aged, 80 and over; Androstanols; Anesthesia, General; Colectomy; Colon, Sigmoid; Diverticulum, Colon

2017
Bradycardia, hypotension and bronchospasm following remifentanil-propofol in a myathenic paitent treated by pyridostigmine--a case report.
    Middle East journal of anaesthesiology, 2008, Volume: 19, Issue:6

    Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Bradycardia; Bronchial Spasm; Cholinesterase I

2008
Rapid sequence intubation using Pentax-AWS without muscle relaxants in patients with myasthenia gravis.
    Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2009, Volume: 47, Issue:3

    Topics: Female; Humans; Intubation, Intratracheal; Myasthenia Gravis; Piperidines; Propofol; Remifentanil

2009
[Anesthetic management using remifentanil target controlled infusion without muscle relaxants in two patients with myasthenia gravis].
    Masui. The Japanese journal of anesthesiology, 2010, Volume: 59, Issue:6

    Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Female; Hemodynamics; Humans; Infusions, I

2010
Recovery from remifentanil after plasmapheresis in a paediatric patient with myasthenia gravis.
    Paediatric anaesthesia, 2003, Volume: 13, Issue:9

    Topics: Adolescent; Analgesics, Opioid; Anesthesia Recovery Period; Anesthetics, Intravenous; Female; Fentan

2003
Propofol and remifentanil without muscle relaxants in a patient with myasthenia gravis for emergency surgery.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:10

    Topics: Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Intravenous; Cholecystitis; Humans; Mal

2003
Remifentanil and high thoracic epidural anaesthesia: a successful combination for patients with myasthenia gravis undergoing transsternal thymectomy.
    European journal of anaesthesiology, 2005, Volume: 22, Issue:5

    Topics: Adult; Analgesics, Opioid; Anesthesia, Epidural; Anesthetics, Combined; Anesthetics, Intravenous; An

2005
Anesthetic implications for video assisted thoracoscopic thymectomy in myasthenia gravis.
    Middle East journal of anaesthesiology, 2005, Volume: 18, Issue:2

    Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; A

2005
Total intravenous anesthesia with propofol and remifentanil for video-assisted thoracoscopic thymectomy in patients with myasthenia gravis.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:1

    Topics: Adult; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Female; Humans; Male;

2006
A combination of total intravenous anesthesia and thoracic epidural for thymectomy in juvenile myasthenia gravis.
    Paediatric anaesthesia, 2007, Volume: 17, Issue:4

    Topics: Adolescent; Amides; Anesthesia, Epidural; Anesthesia, Intravenous; Anesthetics, Combined; Anesthetic

2007
Tracheal intubation without neuromuscular relaxants for thymectomy in myasthenic patients.
    Journal of medicine, 2003, Volume: 34, Issue:1-6

    Topics: Adult; Aged; Anesthesia; Anesthetics, Intravenous; Female; Fentanyl; Humans; Intubation, Intratrache

2003
Laryngeal Mask Airway insertion with total intravenous anesthesia for transsternal thymectomy in patients with myasthenia gravis: report of 5 cases.
    Journal of clinical anesthesia, 2008, Volume: 20, Issue:3

    Topics: Adult; Aged; Airway Resistance; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pressure; C

2008
Total intravenous anesthesia with propofol for thymectomy in a patient with myasthenia gravis.
    Anesthesia progress, 1993, Volume: 40, Issue:4

    Topics: Adult; Anesthesia, General; Anesthesia, Intravenous; Female; Humans; Myasthenia Gravis; Propofol; Th

1993
Response to suxamethonium during propofol-fentanyl-N2O/O2 anaesthesia in a patient with active myasthenia gravis receiving long-term anticholinesterase therapy.
    Anaesthesia, 1994, Volume: 49, Issue:6

    Topics: Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Dose-Response Relationship, Drug; Drug Resis

1994
[A new method of pain sedation following thymectomy in myasthenia gravis. 2 cases].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1994, Volume: 29, Issue:1

    Topics: Adult; Female; Humans; Hypnotics and Sedatives; Middle Aged; Myasthenia Gravis; Pirinitramide; Propo

1994
Total intravenous anesthesia for diagnostic endoscopy in myasthenia gravis child--a case report.
    Middle East journal of anaesthesiology, 1996, Volume: 13, Issue:4

    Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Bronchoscopy; Child; Female; Humans; Laryngoscopy

1996
Propofol anesthesia in a patient with myasthenia gravis--a case report.
    Acta anaesthesiologica Sinica, 1996, Volume: 34, Issue:2

    Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Cholecystectomy, Laparoscopic; Female; Humans; Mi

1996
[Thoracic epidural anesthesia combined with general anesthesia with propofol for thymectomy in myasthenia gravis].
    Revista espanola de anestesiologia y reanimacion, 1997, Volume: 44, Issue:3

    Topics: Adult; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Intravenous; Female; Humans; Myasthen

1997
Remifentanil and propofol total intravenous anaesthesia for thymectomy in myasthenia gravis.
    Anaesthesia and intensive care, 1998, Volume: 26, Issue:2

    Topics: Adolescent; Anesthetics, Combined; Anesthetics, Intravenous; Female; Humans; Myasthenia Gravis; Pipe

1998
Anesthetic management of a patient with myasthenia gravis during hypothermic cardiopulmonary bypass.
    Journal of clinical anesthesia, 1998, Volume: 10, Issue:3

    Topics: Aged; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; Antibodies; Car

1998
[Anesthetic management of a patient with postthymectomy myasthenia gravis].
    Masui. The Japanese journal of anesthesiology, 1999, Volume: 48, Issue:9

    Topics: Anesthesia, Epidural; Anesthesia, General; Anesthetics, Intravenous; Disease Progression; Fentanyl;

1999
Comparison between sevoflurane and propofol neuromuscular effects in a patient with myasthenia gravis: effective doses of vecuronium.
    Anesthesiology, 2001, Volume: 95, Issue:3

    Topics: Adult; Anesthetics; Humans; Male; Methyl Ethers; Myasthenia Gravis; Neuromuscular Junction; Neuromus

2001
[Propofol anesthesia combined with thoracic epidural anesthesia for thymectomy for myasthenia gravis--a report of eleven cases].
    Masui. The Japanese journal of anesthesiology, 2001, Volume: 50, Issue:11

    Topics: Adult; Aged; Anesthesia, Epidural; Anesthesia, Intravenous; Anesthetics, Intravenous; Female; Humans

2001