propofol has been researched along with Multiple Organ Failure in 16 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Multiple Organ Failure: A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess safety and efficacy of propofol and thiopental for refractory status epilepticus (RSE) in children, the authors reviewed 34 episodes of RSE." | 9.11 | Propofol and thiopental for refractory status epilepticus in children. ( Blussé van Oud-Alblas, HJ; Braun, KP; Malingré, M; van Gestel, JP; van Nieuwenhuizen, O; Ververs, FF, 2005) |
| "Propofol infusion syndrome (PRIS) is a rare and often fatal syndrome described in critically ill children undergoing long-term propofol infusion at high doses." | 8.82 | The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. ( Candiani, A; Latronico, N; Rasulo, F; Vasile, B, 2003) |
| "A 33-year-old previously healthy woman was admitted after a drug overdose combining colchicine, atorvastatin, ibuprofen, diclofenac, and furosemide." | 7.76 | Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management. ( Bonbled, F; Hantson, P; Huberlant, V; Montiel, V; Vincent, MF, 2010) |
| "The authors present the hospital course of a 13-year-old girl with a closed head injury who received a prolonged infusion of propofol for sedation and, subsequently, died as a result of severe metabolic acidosis, rhabdomyolysis, and cardiovascular collapse." | 7.71 | Metabolic acidosis, rhabdomyolysis, and cardiovascular collapse after prolonged propofol infusion. ( Bauman, LA; Cannon, ML; Glazier, SS, 2001) |
| "Posttreatment propofol decreased serum TNF-alpha level, increased serum IL-10 level, attenuated the severity of organ damage, and improved survival rate after HS." | 5.35 | Propofol protects against hemorrhagic shock-induced organ damage in conscious spontaneously hypertensive rats. ( Hsu, BG; Lee, CC; Lee, CJ; Lee, RP; Peng, TC; Subeq, YM, 2009) |
| "She developed multiple organ failure with rhabdomyolysis and died." | 5.33 | A case of suspected non-neurosurgical adult fatal propofol infusion syndrome. ( Eriksen, J; Povey, HM, 2006) |
| "To assess safety and efficacy of propofol and thiopental for refractory status epilepticus (RSE) in children, the authors reviewed 34 episodes of RSE." | 5.11 | Propofol and thiopental for refractory status epilepticus in children. ( Blussé van Oud-Alblas, HJ; Braun, KP; Malingré, M; van Gestel, JP; van Nieuwenhuizen, O; Ververs, FF, 2005) |
| "Propofol infusion syndrome (PRIS) is a rare and often fatal syndrome described in critically ill children undergoing long-term propofol infusion at high doses." | 4.82 | The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. ( Candiani, A; Latronico, N; Rasulo, F; Vasile, B, 2003) |
| "A 33-year-old previously healthy woman was admitted after a drug overdose combining colchicine, atorvastatin, ibuprofen, diclofenac, and furosemide." | 3.76 | Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management. ( Bonbled, F; Hantson, P; Huberlant, V; Montiel, V; Vincent, MF, 2010) |
| "High-dose propofol infusion for sedation of patients in the intensive care unit can result in rhabdomyolysis, acute renal failure, metabolic acidosis, hyperkalemia, ventricular arrhythmia, hyperthermia, and death." | 3.73 | A lethal complication of propofol. ( Chavez, VM; Haake, RJ; Hayat, SA; Suen, HC, 2006) |
| "The authors present the hospital course of a 13-year-old girl with a closed head injury who received a prolonged infusion of propofol for sedation and, subsequently, died as a result of severe metabolic acidosis, rhabdomyolysis, and cardiovascular collapse." | 3.71 | Metabolic acidosis, rhabdomyolysis, and cardiovascular collapse after prolonged propofol infusion. ( Bauman, LA; Cannon, ML; Glazier, SS, 2001) |
| "Propofol IRs were recorded, propofol concentrations were measured in the arterial plasma, and blood biochemical parameters and organ histopathology were assessed." | 1.37 | Attenuation of propofol tolerance conferred by remifentanil co-administration does not reduce propofol toxicity in rabbits under prolonged mechanical ventilation. ( Bougioukas, G; Bougioukas, I; Lambropoulou, M; Manolas, C; Mikroulis, D; Papadopoulos, N; Politou, M; Simopoulos, C; Theodoridis, G; Tsigalou, C; Ypsilantis, P, 2011) |
| "Posttreatment propofol decreased serum TNF-alpha level, increased serum IL-10 level, attenuated the severity of organ damage, and improved survival rate after HS." | 1.35 | Propofol protects against hemorrhagic shock-induced organ damage in conscious spontaneously hypertensive rats. ( Hsu, BG; Lee, CC; Lee, CJ; Lee, RP; Peng, TC; Subeq, YM, 2009) |
| "1." | 1.35 | Low-dose propofol ameliorates haemorrhagic shock-induced organ damage in conscious rats. ( Hsu, BG; Lee, CJ; Lee, RP; Subeq, YM; Wu, WT, 2008) |
| " Sevoflurane proved to be a safe alternative medication for prolonged sedation." | 1.34 | Organ toxicity and mortality in propofol-sedated rabbits under prolonged mechanical ventilation. ( Bougioukas, G; Didilis, V; Lambropoulou, M; Manolas, C; Mikroulis, D; Papadopoulos, N; Pitiakoudis, M; Politou, M; Simopoulos, C; Tsigalou, C; Ypsilantis, P, 2007) |
| "She developed multiple organ failure with rhabdomyolysis and died." | 1.33 | A case of suspected non-neurosurgical adult fatal propofol infusion syndrome. ( Eriksen, J; Povey, HM, 2006) |
| "Patients with multiple organ failure may be at risk for unusual pigmentation effects from tube feeding dyes." | 1.31 | Green skin discoloration associated with multiple organ failure. ( Czop, M; Herr, DL, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 12 (75.00) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Patel, C | 1 |
| Kleinig, P | 1 |
| Bakker, M | 1 |
| Tait, P | 1 |
| Shimony, A | 1 |
| Almog, Y | 1 |
| Zahger, D | 1 |
| Lee, CJ | 2 |
| Lee, RP | 2 |
| Subeq, YM | 2 |
| Lee, CC | 1 |
| Peng, TC | 1 |
| Hsu, BG | 2 |
| Ypsilantis, P | 2 |
| Politou, M | 2 |
| Mikroulis, D | 2 |
| Lambropoulou, M | 2 |
| Bougioukas, I | 1 |
| Theodoridis, G | 1 |
| Tsigalou, C | 2 |
| Manolas, C | 2 |
| Papadopoulos, N | 2 |
| Bougioukas, G | 2 |
| Simopoulos, C | 2 |
| Montiel, V | 1 |
| Huberlant, V | 1 |
| Vincent, MF | 1 |
| Bonbled, F | 1 |
| Hantson, P | 1 |
| Crawford, MW | 1 |
| Dodgson, BG | 1 |
| Holtby, HH | 1 |
| Roy, WL | 1 |
| Vasile, B | 1 |
| Rasulo, F | 1 |
| Candiani, A | 1 |
| Latronico, N | 1 |
| Augoustides, JG | 1 |
| Culp, KE | 1 |
| Ochroch, AE | 1 |
| Milas, BL | 1 |
| van Gestel, JP | 1 |
| Blussé van Oud-Alblas, HJ | 1 |
| Malingré, M | 1 |
| Ververs, FF | 1 |
| Braun, KP | 1 |
| van Nieuwenhuizen, O | 1 |
| Suen, HC | 1 |
| Haake, RJ | 1 |
| Chavez, VM | 1 |
| Hayat, SA | 1 |
| Eriksen, J | 1 |
| Povey, HM | 1 |
| Pitiakoudis, M | 1 |
| Didilis, V | 1 |
| Wu, WT | 1 |
| el-Ebiary, M | 1 |
| Torres, A | 1 |
| Ramirez, J | 1 |
| Xaubet, A | 1 |
| Rodriguez-Roisin, R | 1 |
| Cannon, ML | 1 |
| Glazier, SS | 1 |
| Bauman, LA | 1 |
| Czop, M | 1 |
| Herr, DL | 1 |
2 reviews available for propofol and Multiple Organ Failure
| Article | Year |
|---|---|
Palliative sedation: A safety net for the relief of refractory and intolerable symptoms at the end of life.
Topics: Aged; Analgesics; Conscious Sedation; Dehydration; Dyspnea; Humans; Hydromorphone; Hypnotics and Sed | 2019 |
The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome.
Topics: Adult; Animals; Catecholamines; Central Nervous System; Critical Illness; Drug Interactions; Drug Th | 2003 |
1 trial available for propofol and Multiple Organ Failure
| Article | Year |
|---|---|
Propofol and thiopental for refractory status epilepticus in children.
Topics: Anticonvulsants; Child; Clinical Protocols; Dose-Response Relationship, Drug; Drug Administration Sc | 2005 |
13 other studies available for propofol and Multiple Organ Failure
| Article | Year |
|---|---|
Propofol infusion syndrome: a rare cause of multi-organ failure in a man with complicated myocardial infarction.
Topics: Anesthetics, Intravenous; Humans; Male; Middle Aged; Multiple Organ Failure; Myocardial Infarction; | 2008 |
Propofol protects against hemorrhagic shock-induced organ damage in conscious spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Interleukin-10; Kaplan-Meier Est | 2009 |
Attenuation of propofol tolerance conferred by remifentanil co-administration does not reduce propofol toxicity in rabbits under prolonged mechanical ventilation.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Drug Interactions; Drug Tolerance; Gallb | 2011 |
Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management.
Topics: Adult; Atorvastatin; Colchicine; Critical Care; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhib | 2010 |
Propofol syndrome in children.
Topics: Acidosis; Age Factors; Anesthetics, Intravenous; Child; Conscious Sedation; Critical Illness; Hepato | 2003 |
Total suppression of cerebral activity by thiopental mimicking propofol infusion syndrome: a fatal common pathway?
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Brain; Craniotomy; Dose-Response Relationship, Dr | 2005 |
A lethal complication of propofol.
Topics: Acidosis; Acute Kidney Injury; Adult; Anesthetics, Intravenous; Creatine Kinase; Dose-Response Relat | 2006 |
A case of suspected non-neurosurgical adult fatal propofol infusion syndrome.
Topics: Adolescent; Anesthetics, Intravenous; Fatal Outcome; Female; Humans; Hypnotics and Sedatives; Infusi | 2006 |
Organ toxicity and mortality in propofol-sedated rabbits under prolonged mechanical ventilation.
Topics: Animals; Hypnotics and Sedatives; Male; Multiple Organ Failure; Propofol; Rabbits; Respiration, Arti | 2007 |
Low-dose propofol ameliorates haemorrhagic shock-induced organ damage in conscious rats.
Topics: Animals; Consciousness; Male; Multiple Organ Failure; Propofol; Rats; Rats, Inbred WKY; Shock, Hemor | 2008 |
Lipid deposition during the long-term infusion of propofol.
Topics: Aged; Embolism, Fat; Enteral Nutrition; Fatal Outcome; Humans; Hypnotics and Sedatives; Infusions, I | 1995 |
Metabolic acidosis, rhabdomyolysis, and cardiovascular collapse after prolonged propofol infusion.
Topics: Acidosis; Adolescent; Electrocardiography; Fatal Outcome; Female; Head Injuries, Closed; Heart Disea | 2001 |
Green skin discoloration associated with multiple organ failure.
Topics: Acute Kidney Injury; Aged; Analgesics, Opioid; Benzenesulfonates; Coloring Agents; Enteral Nutrition | 2002 |