propofol has been researched along with Morbid Obesity in 63 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the optimal dose of propofol in patients with morbid obesity when the anesthetic induction dosage is calculated based on lean body weight (LBW)." | 9.34 | The appropriate dose of propofol for anesthesia induction in morbidly obese patients. ( Chen, N; Pan, Y; Qiao, N; Simayi, A; Xu, G, 2020) |
| "Propofol dosing based on total body weight (TBW) can lead to overdosing in morbidly obese (MO) patients." | 9.24 | Optimal propofol induction dose in morbidly obese patients: A randomized controlled trial comparing the bispectral index and lean body weight scalar. ( Chung, F; Riad, W; Subramani, Y; Wong, J, 2017) |
| "This small-size pilot study may suggest that propofol-based anesthesia is not related to increased incidence of rhabdomyolysis in morbidly obese patients undergoing short, uncomplicated bariatric surgery." | 9.20 | Comparison of Rhabdomyolysis Markers in Patients Undergoing Bariatric Surgery with Propofol and Inhalation-based Anesthesia. ( Katz, YS; Lehavi, A; Mahajna, A; Sandler, O; Weissman, A, 2015) |
| "Different propofol target concentrations for each PK model must be used for induction when using total body weight in morbidly obese patients." | 9.16 | The effective effect-site propofol concentration for induction and intubation with two pharmacokinetic models in morbidly obese patients using total body weight. ( Bugedo, DA; Cortínez, LI; Donoso, MT; Echevarría, GC; Elgueta, MF; Muñoz, HR, 2012) |
| "Sixty MO subjects (body mass index ≥40 kg/m(2)) were randomized to receive a propofol infusion (100 mg · kg(-1) · h(-1)) for induction of anesthesia based on total body weight (TBW) or lean body weight (LBW)." | 9.15 | Lean body weight scalar for the anesthetic induction dose of propofol in morbidly obese subjects. ( Brodsky, JB; Ingrande, J; Lemmens, HJ, 2011) |
| " Obese patients pose significant challenges to anesthesiologists with regard to accurate dosing of anesthetics due to potentially altered pharmacokinetics (PK)." | 6.82 | Morbid Obesity Alters Both Pharmacokinetics and Pharmacodynamics of Propofol: Dosing Recommendation for Anesthesia Induction. ( Dong, D; Li, J; Liu, J; Peng, X; Qian, H; Wu, B, 2016) |
| "The frequency of postoperative nausea was significantly lower in Group D than that in Group R until 2 h after discharge from the postanesthesia care unit (PACU) (P = 0." | 5.72 | Effect of Dexmedetomidine Compared to Remifentanil During Bariatric Surgery on Postoperative Nausea and Vomiting: a Retrospective Study. ( Han, J; Kim, BY; Koo, BW; Nam, SW; Oh, AY; Yoon, J, 2022) |
| "Automated propofol TIVA as administered by CLADS, which matched desflurane GA with respect to depth of anesthesia consistency and postanesthesia recovery profile, can be explored further as an alternative anesthesia technique in patients with morbid obesity." | 5.69 | Automated Closed-Loop Propofol Anesthesia Versus Desflurane Inhalation Anesthesia in Obese Patients Undergoing Bariatric Surgery: A Comparative Randomized Analysis of Recovery Profile. ( Choudhary, PK; Dutta, A; Gupta, M; Jain, AK; Panday, BC; Puri, GD; Sethi, N; Sood, J, 2023) |
| "For the treatment of bradycardia atropine sulfate should be adjusted at least to lean body weight in order to avoid paradoxical heart rate response in patients with obesity." | 5.42 | Atropine sulfate for treatment of bradycardia in a patient with morbid obesity: what may happen when you least expect it. ( Carron, M; Veronese, S, 2015) |
| "To investigate the optimal dose of propofol in patients with morbid obesity when the anesthetic induction dosage is calculated based on lean body weight (LBW)." | 5.34 | The appropriate dose of propofol for anesthesia induction in morbidly obese patients. ( Chen, N; Pan, Y; Qiao, N; Simayi, A; Xu, G, 2020) |
| "Propofol dosing based on total body weight (TBW) can lead to overdosing in morbidly obese (MO) patients." | 5.24 | Optimal propofol induction dose in morbidly obese patients: A randomized controlled trial comparing the bispectral index and lean body weight scalar. ( Chung, F; Riad, W; Subramani, Y; Wong, J, 2017) |
| "This small-size pilot study may suggest that propofol-based anesthesia is not related to increased incidence of rhabdomyolysis in morbidly obese patients undergoing short, uncomplicated bariatric surgery." | 5.20 | Comparison of Rhabdomyolysis Markers in Patients Undergoing Bariatric Surgery with Propofol and Inhalation-based Anesthesia. ( Katz, YS; Lehavi, A; Mahajna, A; Sandler, O; Weissman, A, 2015) |
| "Twenty obese and morbidly obese children and adolescents with a mean age of 16 years (range 9-18 years), a mean total body weight (TBW) of 125 kg (range 70-184 kg) and a mean body mass index of 46 kg/m(2) (range 31-63 kg/m(2)) were available for pharmacokinetic modelling using a two-compartment pharmacokinetic model (n = 294 propofol concentration measurements)." | 5.16 | Propofol clearance in morbidly obese children and adolescents: influence of age and body size. ( Chidambaran, V; Cox, SL; Diepstraten, J; Esslinger, HR; Inge, TH; Knibbe, CA; Sadhasivam, S; Vinks, AA, 2012) |
| "Different propofol target concentrations for each PK model must be used for induction when using total body weight in morbidly obese patients." | 5.16 | The effective effect-site propofol concentration for induction and intubation with two pharmacokinetic models in morbidly obese patients using total body weight. ( Bugedo, DA; Cortínez, LI; Donoso, MT; Echevarría, GC; Elgueta, MF; Muñoz, HR, 2012) |
| "Sixty MO subjects (body mass index ≥40 kg/m(2)) were randomized to receive a propofol infusion (100 mg · kg(-1) · h(-1)) for induction of anesthesia based on total body weight (TBW) or lean body weight (LBW)." | 5.15 | Lean body weight scalar for the anesthetic induction dose of propofol in morbidly obese subjects. ( Brodsky, JB; Ingrande, J; Lemmens, HJ, 2011) |
| "7) were randomly allocated to receive propofol target-controlled infusion based on a weight adjustment formula (group adjusted) or without adjustment [group total body weight (TBW)]." | 5.14 | No adjustment vs. adjustment formula as input weight for propofol target-controlled infusion in morbidly obese patients. ( Albertin, A; Aldegheri, G; Ceriani, V; Fermo, I; Khairallah, I; La Colla, G; La Colla, L; Lodi, T; Mangano, A; Porta, A, 2009) |
| "While sevoflurane induction and maintenance is a suitable anesthetic modality for obese patients, TIVA can be applied easily in those patients possessing no extra risk factors other than morbid obesity." | 5.09 | Total intravenous anesthesia versus single breath technique and anesthesia maintenance with sevoflurane for bariatric operations. ( Karaca, S; Kose, Y; Salihoglu, Z; Taskin, M; Zengin, K, 2001) |
| "Twenty morbidly obese and 10 lean subjects were each administered propofol for induction of anesthesia at a rate of 100 mg/kg/h based on lean body weight and total body weight for obese and lean subjects, respectively." | 3.96 | The Performance of an Artificial Neural Network Model in Predicting the Early Distribution Kinetics of Propofol in Morbidly Obese and Lean Subjects. ( Chien, A; Gabriel, RA; Ingrande, J; Krasinska, K; Lemmens, HJM; McAuley, J, 2020) |
| "To explore the neuromuscular effects of cisatracurium besylate in morbidly obese patients when dosed according to real body weight under total intravenous anesthesia with propofol." | 3.80 | [Neuromuscular effects of cisatracurium besylate in obese patients]. ( Geng, Z; Wu, X, 2014) |
| "An intragastric balloon filled with 590 ml of saline plus 10 ml of methylene blue was endoscopically placed under sedation in a 22-year-old man with morbid obesity (BMI 42 kg/m2)." | 3.72 | Green urine after intragastric balloon placement for the treatment of morbid obesity. ( Bernante, P; Feltracco, P; Francini, F; Menegon, P; Pelizzo, MR; Toniato, A; Zangrandi, F, 2003) |
| " Pharmacokinetic simulation or target-controlled infusion (TCI) using models that have been adapted to patients with obesity are necessary to select appropriate dosing regimens." | 3.01 | How obesity affects the disposition of intravenous anesthetics. ( Inoue, S; Obara, S; Yoshida, K, 2023) |
| "This study was aimed to investigate differences in antioxidant and anti-inflammatory effects of propofol at two commonly used dosing schedules on morbidly obese patients." | 3.01 | Reduced antioxidant and anti-inflammatory effects of propofol at high-dose on morbidly obese patients. ( Li, J; Li, JY; Peng, X; Wu, Z, 2021) |
| "Morbid obesity is associated with adverse airway events including desaturation during deep sedation." | 2.90 | High-flow versus standard nasal cannula in morbidly obese patients during colonoscopy: A prospective, randomized clinical trial. ( Fox, AA; Minhajuddin, A; Nasir, D; Riccio, CA; Sarmiento, S, 2019) |
| " Obese patients pose significant challenges to anesthesiologists with regard to accurate dosing of anesthetics due to potentially altered pharmacokinetics (PK)." | 2.82 | Morbid Obesity Alters Both Pharmacokinetics and Pharmacodynamics of Propofol: Dosing Recommendation for Anesthesia Induction. ( Dong, D; Li, J; Liu, J; Peng, X; Qian, H; Wu, B, 2016) |
| "In view of the increasing prevalence of morbidly obese patients, the influence of excessive total bodyweight (TBW) on the pharmacokinetics and pharmacodynamics of propofol was characterized in this study using bispectral index (BIS) values as a pharmacodynamic endpoint." | 2.76 | Population pharmacokinetics and pharmacodynamics of propofol in morbidly obese patients. ( Danhof, M; Deneer, VH; Diepstraten, J; Knibbe, CA; Peeters, MY; van Dongen, EP; van Kralingen, S; van Ramshorst, B; Wiezer, RJ, 2011) |
| " In conclusion, the duration of action of cisatracurium was prolonged in morbidly obese patients when dosed according to RBW compared with a control group of normal weight patients." | 2.71 | The effects of cisatracurium on morbidly obese women. ( Gullo, A; Leykin, Y; Lomangino, G; Lucca, M; Marzano, B; Pellis, T, 2004) |
| "Results from this study confirm the absence of propofol accumulation in morbidly obese patients when the current dosing scheme is used." | 2.67 | Propofol infusion for maintenance of anesthesia in morbidly obese patients receiving nitrous oxide. A clinical and pharmacokinetic study. ( Desmonts, JM; Farinotti, R; Haberer, JP; Servin, F, 1993) |
| "The frequency of postoperative nausea was significantly lower in Group D than that in Group R until 2 h after discharge from the postanesthesia care unit (PACU) (P = 0." | 1.72 | Effect of Dexmedetomidine Compared to Remifentanil During Bariatric Surgery on Postoperative Nausea and Vomiting: a Retrospective Study. ( Han, J; Kim, BY; Koo, BW; Nam, SW; Oh, AY; Yoon, J, 2022) |
| "Obesity is a disease of increasing prevalence." | 1.56 | Safety and Efficacy of Moderate Sedation in Super Obese Patients Undergoing Lower and Upper GI Endoscopy: a Case-Control Study. ( Benson, M; Caldis, M; Gopal, D; Hubers, J; Pfau, P, 2020) |
| "Propofol TIVA was performed following the Servin formula, while sevoflurane was administered based on the age of the patients." | 1.43 | A comparison of BIS recordings during propofol-based total intravenous anaesthesia and sevoflurane-based inhalational anaesthesia in obese patients. ( Gaszyński, T; Wieczorek, A, 2016) |
| "For the treatment of bradycardia atropine sulfate should be adjusted at least to lean body weight in order to avoid paradoxical heart rate response in patients with obesity." | 1.42 | Atropine sulfate for treatment of bradycardia in a patient with morbid obesity: what may happen when you least expect it. ( Carron, M; Veronese, S, 2015) |
| "Obesity is associated with important physiologic changes that can potentially affect the pharmacokinetic (PK) and pharmacodynamic (PD) profile of anesthetic drugs." | 1.40 | Performance of propofol target-controlled infusion models in the obese: pharmacokinetic and pharmacodynamic analysis. ( Cortínez, LI; Crovari, F; De la Fuente, N; Eleveld, DJ; Ibacache, M; Oliveros, A; Sepulveda, P; Solari, S, 2014) |
| "Uncertainty exists as to the most suitable pharmacokinetic parameter sets for propofol target-controlled infusions (TCI)." | 1.38 | Allometric or lean body mass scaling of propofol pharmacokinetics: towards simplifying parameter sets for target-controlled infusions. ( Coetzee, JF, 2012) |
| "For remifentanil, weight was corrected according to IBW." | 1.34 | Predictive performance of 'Servin's formula' during BIS-guided propofol-remifentanil target-controlled infusion in morbidly obese patients. ( Albertin, A; Bergonzi, PC; Dedola, E; Fermo, I; Gonfalini, M; La Colla, G; La Colla, L; Pasculli, N; Poli, D; Turi, S, 2007) |
| "Morbid obesity is defined as body mass index (BMI) > 35 kg." | 1.34 | The use of propofol and remifentanil for the anaesthetic management of a super-obese patient. ( Albertin, A; Baruffaldi Preis, FW; La Colla, G; La Colla, L; Mangano, A; Poli, D, 2007) |
| "Propofol infusion rate was determined using the corrected body weight drawn by Servin et al." | 1.31 | [Anesthetic management of a morbidly obese patient undergoing laparoscopic gastric bypass surgery]. ( Anbe, A; Hirabayashi, Y; Horikawa, Y; Saitoh, K; Seo, N, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.59) | 18.7374 |
| 1990's | 1 (1.59) | 18.2507 |
| 2000's | 17 (26.98) | 29.6817 |
| 2010's | 37 (58.73) | 24.3611 |
| 2020's | 7 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Nam, SW | 1 |
| Oh, AY | 1 |
| Koo, BW | 1 |
| Kim, BY | 1 |
| Han, J | 1 |
| Yoon, J | 1 |
| Obara, S | 1 |
| Yoshida, K | 1 |
| Inoue, S | 1 |
| Dutta, A | 1 |
| Sethi, N | 1 |
| Puri, GD | 1 |
| Sood, J | 1 |
| Choudhary, PK | 1 |
| Jain, AK | 1 |
| Panday, BC | 1 |
| Gupta, M | 1 |
| Öztürk, MC | 1 |
| Demiroluk, Ö | 1 |
| Abitagaoglu, S | 1 |
| Ari, DE | 1 |
| Benson, M | 1 |
| Hubers, J | 1 |
| Caldis, M | 1 |
| Gopal, D | 1 |
| Pfau, P | 1 |
| Xu, G | 1 |
| Qiao, N | 1 |
| Pan, Y | 1 |
| Simayi, A | 1 |
| Chen, N | 1 |
| Ingrande, J | 2 |
| Gabriel, RA | 1 |
| McAuley, J | 1 |
| Krasinska, K | 1 |
| Chien, A | 1 |
| Lemmens, HJM | 1 |
| Li, J | 3 |
| Li, JY | 1 |
| Wu, Z | 2 |
| Peng, X | 3 |
| Elbakry, AE | 1 |
| Sultan, WE | 1 |
| Ibrahim, E | 1 |
| Cortínez, LI | 4 |
| Sepúlveda, P | 2 |
| Rolle, A | 1 |
| Cottin, P | 1 |
| Guerrini, A | 1 |
| Anderson, BJ | 1 |
| Chiravuri, D | 1 |
| Owusu-Bediako, K | 1 |
| Nafiu, OO | 1 |
| Subramani, Y | 2 |
| Riad, W | 2 |
| Chung, F | 2 |
| Wong, J | 2 |
| Wang, C | 1 |
| Yang, J | 1 |
| Chen, X | 1 |
| Yang, W | 1 |
| Xiong, Z | 1 |
| Riccio, CA | 1 |
| Sarmiento, S | 1 |
| Minhajuddin, A | 1 |
| Nasir, D | 1 |
| Fox, AA | 1 |
| Friesen, JHP | 1 |
| de la Fuente, NF | 1 |
| Puga, VA | 1 |
| Muñoz, HR | 2 |
| Goudra, BG | 1 |
| Ortego, A | 1 |
| Selassie, M | 1 |
| Sinha, AC | 1 |
| Sidransky, MA | 1 |
| Tran, NV | 1 |
| Kaye, AD | 1 |
| Levitt, C | 1 |
| Wei, H | 1 |
| De la Fuente, N | 1 |
| Eleveld, DJ | 2 |
| Oliveros, A | 1 |
| Crovari, F | 1 |
| Ibacache, M | 1 |
| Solari, S | 1 |
| Fernandes, A | 1 |
| Ettinger, J | 1 |
| Amaral, F | 1 |
| Ramalho, MJ | 1 |
| Alves, R | 1 |
| Módolo, NS | 1 |
| Geng, Z | 1 |
| Wu, X | 1 |
| Carron, M | 2 |
| Veronese, S | 1 |
| Lehavi, A | 1 |
| Sandler, O | 1 |
| Mahajna, A | 1 |
| Weissman, A | 1 |
| Katz, YS | 1 |
| Friesen, JH | 2 |
| Dong, D | 1 |
| Liu, J | 1 |
| Qian, H | 1 |
| Wu, B | 1 |
| Kılıc, E | 1 |
| Demiriz, B | 1 |
| Isıkay, N | 1 |
| Yıldırım, AE | 1 |
| Can, S | 1 |
| Basmacı, C | 1 |
| Gaszyński, T | 2 |
| Wieczorek, A | 1 |
| Tsui, BC | 1 |
| Murtha, L | 1 |
| Lemmens, HJ | 2 |
| Bui, AH | 1 |
| Marco, AP | 1 |
| La Colla, L | 3 |
| Albertin, A | 3 |
| La Colla, G | 3 |
| Ceriani, V | 1 |
| Lodi, T | 1 |
| Porta, A | 1 |
| Aldegheri, G | 1 |
| Mangano, A | 2 |
| Khairallah, I | 1 |
| Fermo, I | 2 |
| Coetzee, JF | 2 |
| Freo, U | 1 |
| Ori, C | 1 |
| van Kralingen, S | 3 |
| Diepstraten, J | 4 |
| van de Garde, EM | 2 |
| van der Lely, AJ | 1 |
| van Dongen, EP | 3 |
| van Ramshorst, B | 3 |
| Knibbe, CA | 4 |
| Tsukahara, Y | 1 |
| Ozawa, M | 1 |
| Joshita, S | 1 |
| Mochizuki, K | 1 |
| Kikuchi, T | 1 |
| Nitta, K | 1 |
| Dohgomori, H | 1 |
| Okamoto, K | 1 |
| Brodsky, JB | 1 |
| Jaoua, H | 1 |
| Zghidi, S | 1 |
| Askri, A | 1 |
| Jendoubi, A | 1 |
| Ammar, N | 1 |
| Lassili, S | 1 |
| Laaribi, W | 1 |
| Darmoul, S | 1 |
| Khelifi, S | 1 |
| Ben Fadhel, K | 1 |
| Dewachter, P | 1 |
| Mouton-Faivre, C | 1 |
| Emala, CW | 1 |
| Beloucif, S | 1 |
| Pösö, T | 1 |
| Kesek, D | 1 |
| Winsö, O | 1 |
| Andersson, S | 1 |
| Deneer, VH | 2 |
| Peeters, MY | 1 |
| Wiezer, RJ | 1 |
| Danhof, M | 1 |
| Proost, JH | 1 |
| Absalom, AR | 1 |
| Struys, MM | 1 |
| Chidambaran, V | 1 |
| Sadhasivam, S | 1 |
| Esslinger, HR | 1 |
| Cox, SL | 1 |
| Inge, TH | 1 |
| Vinks, AA | 1 |
| Echevarría, GC | 1 |
| Elgueta, MF | 1 |
| Donoso, MT | 1 |
| Bugedo, DA | 1 |
| Igarashi, T | 1 |
| Nagata, O | 2 |
| Iwakiri, H | 1 |
| Ikeda, M | 1 |
| Uezono, S | 1 |
| Ozaki, M | 1 |
| Bernante, P | 1 |
| Francini, F | 1 |
| Zangrandi, F | 1 |
| Menegon, P | 1 |
| Toniato, A | 1 |
| Feltracco, P | 1 |
| Pelizzo, MR | 1 |
| Leykin, Y | 1 |
| Pellis, T | 1 |
| Lucca, M | 1 |
| Lomangino, G | 1 |
| Marzano, B | 1 |
| Gullo, A | 1 |
| Strzelczyk, J | 1 |
| Machala, W | 1 |
| Gaszynski, W | 1 |
| Poli, D | 2 |
| Gonfalini, M | 1 |
| Turi, S | 1 |
| Pasculli, N | 1 |
| Bergonzi, PC | 1 |
| Dedola, E | 1 |
| Ebert, TJ | 1 |
| Shankar, H | 1 |
| Haake, RM | 1 |
| Baruffaldi Preis, FW | 1 |
| Bakhamees, HS | 1 |
| El-Halafawy, YM | 1 |
| El-Kerdawy, HM | 1 |
| Gouda, NM | 1 |
| Altemyatt, S | 1 |
| Madan, AK | 1 |
| Tichansky, DS | 1 |
| Isom, J | 1 |
| Minard, G | 1 |
| Bee, TK | 1 |
| Servin, F | 1 |
| Farinotti, R | 1 |
| Haberer, JP | 1 |
| Desmonts, JM | 1 |
| Sakai, T | 1 |
| Matsuki, A | 1 |
| White, PF | 1 |
| Giesecke, AH | 1 |
| Alvarez, AO | 1 |
| Cascardo, A | 1 |
| Albarracin Menendez, S | 1 |
| Capria, JJ | 1 |
| Cordero, RA | 1 |
| Saijo, H | 1 |
| Kitamura, T | 1 |
| Fujiwara, H | 1 |
| Hagiwara-Oguchi, K | 1 |
| Ide, Y | 1 |
| Tagami, M | 1 |
| Hanaoka, K | 1 |
| Salihoglu, Z | 1 |
| Karaca, S | 1 |
| Kose, Y | 1 |
| Zengin, K | 1 |
| Taskin, M | 1 |
| Horikawa, Y | 1 |
| Saitoh, K | 1 |
| Anbe, A | 1 |
| Hirabayashi, Y | 1 |
| Seo, N | 1 |
| Kirby, IJ | 1 |
| Howard, EC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A High Resolution Pharmacokinetic/Pharmacodynamic Model of Propofol in Morbidly Obese Subjects[NCT01591148] | Phase 1 | 30 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Comparative Study Between Inhalational Anaesthesia and Total Intravenous Anaesthesia (TIVA) With Dexmedetomidine for Morbidly Obese Patients Undergoing Laparoscopic Sleeve Gastrectomy[NCT03029715] | 100 participants (Actual) | Interventional | 2014-02-28 | Completed | |||
| Propofol Effect-Site Target Controlled Infusion in the Obese: Characterization of the Time Profile of Bispectral Index Response.[NCT01665079] | Phase 4 | 14 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| Investigation of the Clinical Efficacy of High Flow Nasal Oxygen in Patients Over 60 Years of Age Undergoing Colonoscopy[NCT05396274] | 70 participants (Anticipated) | Interventional | 2022-05-26 | Not yet recruiting | |||
| Development of Pharmacokinetic / Pharmacodynamic (pk/pd) Model of Propofol in Patients With Severe Burns[NCT03704285] | 15 participants (Actual) | Observational | 2018-09-29 | Terminated (stopped due to Outbreak COVID 19) | |||
| Validation of a Pharmacokinetic Pharmacodynamic Model to Administer Propofol in Obese Patients[NCT01596387] | Phase 4 | 20 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| Population Pharmacokinetics and Pharmacodynamics of Propofol in the Morbidly Obese Patient[NCT00395681] | Phase 4 | 20 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| A Non-Interventional Study to Develop a Pharmacokinetic - Pharmacodynamic Model for Individualized Propofol Dosing[NCT00948597] | 26 participants (Actual) | Observational | 2009-07-31 | Completed | |||
| Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Research Project[NCT00474318] | 250 participants (Actual) | Observational | 2007-03-31 | Active, not recruiting | |||
| A Comparison of Cerebral Oximetry After Propofol-Based Total Intravenous Anesthesia and Sevoflurane Inhalation Anesthesia in Morbidly Obese Patients Undergoing LSG: a Prospective, Single-Blinded, Randomized, Parallel-Group Study.[NCT03946657] | Phase 4 | 60 participants (Actual) | Interventional | 2019-01-20 | Completed | ||
| Intravenous Anesthesia in Obese Patients: Propofol and Remifentanil Requirements[NCT00779844] | Phase 4 | 63 participants (Actual) | Interventional | 2008-12-31 | Terminated (stopped due to difficulty in recruiting) | ||
| Evaluation of a Novel Closed-loop Propofol and Remifentanil System Guided by Bispectral Index Compared to a TCI Open-loop System: a Randomized Controlled Trial.[NCT02492282] | Phase 3 | 150 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total paracetamol consumption. (NCT03029715)
Timeframe: Within one hour after surgery
| Intervention | mg (Mean) |
|---|---|
| Sleeve Gastrectomy 1 | 3.56 |
| Sleeve Gastrectomy 2 | 1.67 |
(NCT03029715)
Timeframe: During operation and follow-up, an average of 2 hours
| Intervention | mmHg (Mean) |
|---|---|
| Sleeve Gastrectomy 1 | 71.05 |
| Sleeve Gastrectomy 2 | 62.7 |
1 review available for propofol and Morbid Obesity
| Article | Year |
|---|---|
How obesity affects the disposition of intravenous anesthetics.
Topics: Anesthetics, Intravenous; Humans; Obesity; Obesity, Morbid; Propofol; Remifentanil | 2023 |
22 trials available for propofol and Morbid Obesity
| Article | Year |
|---|---|
Automated Closed-Loop Propofol Anesthesia Versus Desflurane Inhalation Anesthesia in Obese Patients Undergoing Bariatric Surgery: A Comparative Randomized Analysis of Recovery Profile.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2023 |
The Effect of sevoflurane, desflurane and propofol on respiratory mechanics and integrated pulmonary index scores in laparoscopic sleeve gastrectomy. A randomized trial.
Topics: Adult; Anesthetics, Inhalation; Desflurane; Female; Gastrectomy; Humans; Lung; Male; Middle Aged; Ob | 2019 |
The appropriate dose of propofol for anesthesia induction in morbidly obese patients.
Topics: Anesthesia; Anesthetics, Intravenous; Humans; Obesity, Morbid; Propofol | 2020 |
Reduced antioxidant and anti-inflammatory effects of propofol at high-dose on morbidly obese patients.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Anti-Inflammatory Agents; Antioxidants; Drug D | 2021 |
A comparison between inhalational (Desflurane) and total intravenous anaesthesia (Propofol and dexmedetomidine) in improving postoperative recovery for morbidly obese patients undergoing laparoscopic sleeve gastrectomy: A double-blinded randomised control
Topics: Adult; Analgesics; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anes | 2018 |
Characterization of cardiovascular depression effect for propofol during anesthesia induction period on morbidly obese patients.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Blood Pressure; Body Mass Index; Body Weight; Cardiac O | 2018 |
High-flow versus standard nasal cannula in morbidly obese patients during colonoscopy: A prospective, randomized clinical trial.
Topics: Aged; Cannula; Colonoscopy; Deep Sedation; Female; Humans; Hypoxia; Male; Middle Aged; Noninvasive V | 2019 |
General anesthesia type does not influence serum levels of neutrophil gelatinase-associated lipocalin during the perioperative period in video laparoscopic bariatric surgery.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Adult; Anesthesia, General; Anesthesia, Intravenous; Anes | 2014 |
Comparison of Rhabdomyolysis Markers in Patients Undergoing Bariatric Surgery with Propofol and Inhalation-based Anesthesia.
Topics: Adult; Anesthesia, Inhalation; Anesthetics, Intravenous; Bariatric Surgery; Biomarkers; Female; Gast | 2015 |
Morbid Obesity Alters Both Pharmacokinetics and Pharmacodynamics of Propofol: Dosing Recommendation for Anesthesia Induction.
Topics: Anesthetics, Intravenous; Female; Humans; Male; Middle Aged; Models, Biological; Obesity, Morbid; Pr | 2016 |
Alfentanil versus ketamine combined with propofol for sedation during upper gastrointestinal system endoscopy in morbidly obese patients.
Topics: Adult; Alfentanil; Anesthetics, Combined; Anesthetics, Intravenous; Body Mass Index; Deep Sedation; | 2016 |
Optimal propofol induction dose in morbidly obese patients: A randomized controlled trial comparing the bispectral index and lean body weight scalar.
Topics: Adult; Anesthetics, Intravenous; Body Weight; Consciousness Monitors; Dose-Response Relationship, Dr | 2017 |
No adjustment vs. adjustment formula as input weight for propofol target-controlled infusion in morbidly obese patients.
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Weight; Dose-Response Relationship, D | 2009 |
Comparative evaluation of propofol 350 and 200 mg for induction of anaesthesia in morbidly obese patients: a randomized double-blind pilot study.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Double-Blind Method; Electroencephalography; Huma | 2010 |
Lean body weight scalar for the anesthetic induction dose of propofol in morbidly obese subjects.
Topics: Adult; Anesthesia, Intravenous; Body Mass Index; Body Weight; Dose-Response Relationship, Drug; Fema | 2011 |
Population pharmacokinetics and pharmacodynamics of propofol in morbidly obese patients.
Topics: Anesthetics, Intravenous; Body Mass Index; Body Weight; Consciousness Monitors; Female; Humans; Male | 2011 |
Propofol clearance in morbidly obese children and adolescents: influence of age and body size.
Topics: Adolescent; Age Factors; Anesthetics, Intravenous; Body Weight; Child; Dose-Response Relationship, D | 2012 |
Propofol clearance in morbidly obese children and adolescents: influence of age and body size.
Topics: Adolescent; Age Factors; Anesthetics, Intravenous; Body Weight; Child; Dose-Response Relationship, D | 2012 |
Propofol clearance in morbidly obese children and adolescents: influence of age and body size.
Topics: Adolescent; Age Factors; Anesthetics, Intravenous; Body Weight; Child; Dose-Response Relationship, D | 2012 |
Propofol clearance in morbidly obese children and adolescents: influence of age and body size.
Topics: Adolescent; Age Factors; Anesthetics, Intravenous; Body Weight; Child; Dose-Response Relationship, D | 2012 |
The effective effect-site propofol concentration for induction and intubation with two pharmacokinetic models in morbidly obese patients using total body weight.
Topics: Adult; Body Weight; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Intubation, In | 2012 |
The effects of cisatracurium on morbidly obese women.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Atracurium; Body Mass Index; Body Weight; Cali | 2004 |
Effects of dexmedetomidine in morbidly obese patients undergoing laparoscopic gastric bypass.
Topics: Adrenergic alpha-Agonists; Aged; Analgesics, Opioid; Anastomosis, Roux-en-Y; Anesthesia, Intravenous | 2007 |
Propofol infusion for maintenance of anesthesia in morbidly obese patients receiving nitrous oxide. A clinical and pharmacokinetic study.
Topics: Adult; Aged; Anesthesia, General; Drug Synergism; Female; Humans; Infusions, Intravenous; Male; Midd | 1993 |
Propofol infusion for maintenance of anesthesia in morbidly obese patients receiving nitrous oxide. A clinical and pharmacokinetic study.
Topics: Adult; Aged; Anesthesia, General; Drug Synergism; Female; Humans; Infusions, Intravenous; Male; Midd | 1993 |
Propofol infusion for maintenance of anesthesia in morbidly obese patients receiving nitrous oxide. A clinical and pharmacokinetic study.
Topics: Adult; Aged; Anesthesia, General; Drug Synergism; Female; Humans; Infusions, Intravenous; Male; Midd | 1993 |
Propofol infusion for maintenance of anesthesia in morbidly obese patients receiving nitrous oxide. A clinical and pharmacokinetic study.
Topics: Adult; Aged; Anesthesia, General; Drug Synergism; Female; Humans; Infusions, Intravenous; Male; Midd | 1993 |
Total intravenous anesthesia versus single breath technique and anesthesia maintenance with sevoflurane for bariatric operations.
Topics: Adult; Alfentanil; Analysis of Variance; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthe | 2001 |
40 other studies available for propofol and Morbid Obesity
| Article | Year |
|---|---|
Effect of Dexmedetomidine Compared to Remifentanil During Bariatric Surgery on Postoperative Nausea and Vomiting: a Retrospective Study.
Topics: Adult; Analgesics; Analgesics, Opioid; Antiemetics; Bariatric Surgery; Dexmedetomidine; Double-Blind | 2022 |
Safety and Efficacy of Moderate Sedation in Super Obese Patients Undergoing Lower and Upper GI Endoscopy: a Case-Control Study.
Topics: Case-Control Studies; Conscious Sedation; Endoscopy; Humans; Obesity; Obesity, Morbid; Propofol | 2020 |
The Performance of an Artificial Neural Network Model in Predicting the Early Distribution Kinetics of Propofol in Morbidly Obese and Lean Subjects.
Topics: Adult; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Circulation; Body Compos | 2020 |
Effect-Site Target-Controlled Infusion in the Obese: Model Derivation and Performance Assessment.
Topics: Adult; Aged; Anesthetics, Intravenous; Body Mass Index; Body Weight; Consciousness; Consciousness Mo | 2018 |
Optimal propofol induction dose in morbidly obese patients: bispectral index guidance is not the answer.
Topics: Anesthetics, Intravenous; Electroencephalography; Humans; Obesity, Morbid; Propofol | 2018 |
In reply: Optimal propofol induction dose in morbidly obese patients: bispectral index guidance is not the answer.
Topics: Anesthetics, Intravenous; Electroencephalography; Humans; Obesity, Morbid; Propofol | 2018 |
Propofol pharmacokinetic model and lean body weight scalar for dose estimation in morbid obesity.
Topics: Anesthesia; Anesthesiology; Anesthetics, Intravenous; Humans; Obesity, Morbid; Propofol | 2019 |
The effective effect-site propofol concentration for induction in morbidly obese patients using total body weight with a new pharmacokinetic model.
Topics: Body Weight; Humans; Intubation, Intratracheal; Male; Models, Chemical; Obesity, Morbid; Propofol | 2013 |
Lessons from providing total intravenous anesthesia (TIVA) to a morbidly obese patient (294 kg [648 lbs], body mass index 85.5 kg/m2).
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Mass Index; Humans; Male; Obesity, Mo | 2013 |
Anesthesia considerations in stiff person syndrome.
Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Catheters, Indwelling; Humans; Lidocaine; Male; | 2013 |
Supraglotic pulsatile jet oxygenation and ventilation during deep propofol sedation for upper gastrointestinal endoscopy in a morbidly obese patient.
Topics: Deep Sedation; Endoscopy, Gastrointestinal; Female; Humans; Hypnotics and Sedatives; Middle Aged; Ob | 2014 |
Performance of propofol target-controlled infusion models in the obese: pharmacokinetic and pharmacodynamic analysis.
Topics: Adult; Anesthetics, Intravenous; Bariatric Surgery; Body Mass Index; Body Weight; Consciousness; Con | 2014 |
Performance of propofol target-controlled infusion models in the obese: pharmacokinetic and pharmacodynamic analysis.
Topics: Adult; Anesthetics, Intravenous; Bariatric Surgery; Body Mass Index; Body Weight; Consciousness; Con | 2014 |
Performance of propofol target-controlled infusion models in the obese: pharmacokinetic and pharmacodynamic analysis.
Topics: Adult; Anesthetics, Intravenous; Bariatric Surgery; Body Mass Index; Body Weight; Consciousness; Con | 2014 |
Performance of propofol target-controlled infusion models in the obese: pharmacokinetic and pharmacodynamic analysis.
Topics: Adult; Anesthetics, Intravenous; Bariatric Surgery; Body Mass Index; Body Weight; Consciousness; Con | 2014 |
[Neuromuscular effects of cisatracurium besylate in obese patients].
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Atracurium; Body Mass Inde | 2014 |
Atropine sulfate for treatment of bradycardia in a patient with morbid obesity: what may happen when you least expect it.
Topics: Aged; Anesthesia, General; Anti-Arrhythmia Agents; Atrioventricular Block; Atropine; Bradycardia; De | 2015 |
Estimating the induction dose of propofol in morbid obesity: striking a happy medium.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Humans; Lipids; Obesity, Morbid; Propofol | 2016 |
A comparison of BIS recordings during propofol-based total intravenous anaesthesia and sevoflurane-based inhalational anaesthesia in obese patients.
Topics: Adolescent; Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthe | 2016 |
Practical dosing of propofol in morbidly obese patients.
Topics: Anesthetics, Intravenous; Humans; Obesity, Morbid; Propofol | 2017 |
Propofol induction: normalizing the dose in morbidly obese patients.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Humans; Obesity, Morbid; Propofol | 2017 |
Peripheral nerve blockade in a patient with Charcot-Marie-Tooth disease.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Bupivacaine; Charcot-Marie-To | 2008 |
Total intravenous anaesthesia to obese patients: largely guesswork?
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Body Weight; Dose-Response Relationship, Drug; Hu | 2009 |
Occurrence and care of an obese patient during a serious adverse event with propofol for an endoscopy procedure.
Topics: Adult; Anesthetics, Intravenous; Conscious Sedation; Female; Gastric Balloon; Humans; Infusions, Int | 2011 |
[Anesthesia for a patient with morbid obesity, systemic edema and airway burn].
Topics: Adult; Anesthesia, Intravenous; Burns; Edema; Fentanyl; Humans; Intubation, Intratracheal; Laryngosc | 2010 |
[Target-controlled intravenous anesthesia during laparoscopic surgery for obesity].
Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Feasibility Studies; Humans; Infusions, Intrave | 2011 |
Case scenario: bronchospasm during anesthetic induction.
Topics: Adult; Albuterol; Anesthesia; Anesthetics, Intravenous; Anti-Inflammatory Agents; Bronchial Spasm; B | 2011 |
Volatile rapid sequence induction in morbidly obese patients.
Topics: Adolescent; Adult; Aged; Alfentanil; Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, I | 2011 |
Maintenance of anesthesia in morbidly obese patients using propofol with continuous BIS-monitoring: a comparison of propofol-remifentanil and propofol-epidural anesthesia.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Intravenous; Anesthetics, Intravenous; Bariatric Surgery; B | 2011 |
Obesity and allometric scaling of pharmacokinetics.
Topics: Anesthetics, Intravenous; Female; Humans; Male; Obesity, Morbid; Propofol | 2011 |
Allometric or lean body mass scaling of propofol pharmacokinetics: towards simplifying parameter sets for target-controlled infusions.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthetics, Intravenous; Body Size; Body W | 2012 |
[Two cases of intraoperative awareness during intravenous anesthesia with propofol in morbidly obese patients].
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Consciousness; Female; Fentanyl; Humans; I | 2002 |
Green urine after intragastric balloon placement for the treatment of morbid obesity.
Topics: Adult; Anesthetics, Intravenous; Endoscopy; Gastric Balloon; Humans; Indicators and Reagents; Male; | 2003 |
Reduction of a total propofol consumption in morbidly obese patients during general anesthesia due to BIS monitoring.
Topics: Anesthetics, General; Electroencephalography; Humans; Monitoring, Intraoperative; Obesity, Morbid; P | 2005 |
Predictive performance of 'Servin's formula' during BIS-guided propofol-remifentanil target-controlled infusion in morbidly obese patients.
Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Body Weight; Computer Simulation; Drug Delivery | 2007 |
Perioperative considerations for patients with morbid obesity.
Topics: Anesthesia, General; Anesthesia, Inhalation; Anesthetics, Intravenous; Humans; Intubation, Intratrac | 2006 |
The use of propofol and remifentanil for the anaesthetic management of a super-obese patient.
Topics: Anesthetics, Combined; Anesthetics, Intravenous; Bariatric Surgery; Humans; Male; Middle Aged; Obesi | 2007 |
Monitored anesthesia care with propofol versus surgeon-monitored sedation with benzodiazepines and narcotics for preoperative endoscopy in the morbidly obese.
Topics: Anesthesiology; Anesthetics, Intravenous; Bariatric Surgery; Benzodiazepines; Conscious Sedation; En | 2008 |
Use of an EEG-bispectral closed-loop delivery system for administering propofol.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Asthma; Electroence | 2000 |
Total intravenous anesthesia with midazolam, remifentanil, propofol and cistracurium in morbid obesity.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; Atracurium; Fe | 2000 |
[Anesthetic management of a hyper-obese patient by target-controlled infusion (TCI) of propofol and fentanyl].
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Fentanyl; Humans; Infusions, Intravenous; | 2001 |
[Anesthetic management of a morbidly obese patient undergoing laparoscopic gastric bypass surgery].
Topics: Adult; Anesthesia, Epidural; Anesthesia, Intravenous; Body Weight; Gastric Bypass; Humans; Laparosco | 2001 |
Propofol in a morbidly obese patient.
Topics: Adult; Anesthesia, General; Anesthetics; Female; Humans; Obesity, Morbid; Phenols; Propofol | 1987 |