propofol has been researched along with Mitochondrial Diseases in 11 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The clinical features of propofol infusion syndrome (PRIS) are acute refractory bradycardia leading to asystole, in the presence of one or more of the following: metabolic acidosis (base deficit > 10 mmol." | 8.84 | Propofol infusion syndrome. ( Cardone, D; Kam, PC, 2007) |
| "The clinical features of propofol infusion syndrome (PRIS) are acute refractory bradycardia leading to asystole, in the presence of one or more of the following: metabolic acidosis (base deficit > 10 mmol." | 4.84 | Propofol infusion syndrome. ( Cardone, D; Kam, PC, 2007) |
| "Following a propofol anesthetic, a 5-year-old girl with lower extremity spasticity seized and developed hypertriglyceridemia, hyperkalemia, and metabolic acidosis." | 3.79 | Propofol infusion syndrome or adrenoleukodystrophy? ( Agin, H; Goktay, A; Karaarslan, U; Karaman, Y, 2013) |
| "Mitochondrial disorders are a clinically and biochemically diverse group of disorders which may involve multiple organ systems." | 2.55 | A review of anaesthetic outcomes in patients with genetically confirmed mitochondrial disorders. ( Crushell, E; Dunne, E; Eustace, N; Hughes, J; Knerr, I; Mannion, M; Monavari, AA; O'Connor, C; Smith, A, 2017) |
| "There are indications that preexisting mitochondrial disorders or beta-oxidation defects predispose for propofol infusion syndrome." | 2.53 | Propofol Is Mitochondrion-Toxic and May Unmask a Mitochondrial Disorder. ( Finsterer, J; Frank, M, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 10 (90.91) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saettele, AK | 1 |
| Sharma, A | 1 |
| Murray, DJ | 1 |
| Savard, M | 3 |
| Dupré, N | 1 |
| Turgeon, AF | 3 |
| Desbiens, R | 1 |
| Langevin, S | 1 |
| Brunet, D | 1 |
| Mtaweh, H | 2 |
| Bayır, H | 2 |
| Kochanek, PM | 2 |
| Bell, MJ | 2 |
| Lerman, J | 1 |
| Everett, L | 1 |
| Cote, CJ | 1 |
| Parness, J | 1 |
| Finsterer, J | 1 |
| Frank, M | 1 |
| Smith, A | 1 |
| Dunne, E | 1 |
| Mannion, M | 1 |
| O'Connor, C | 1 |
| Knerr, I | 1 |
| Monavari, AA | 1 |
| Hughes, J | 1 |
| Eustace, N | 1 |
| Crushell, E | 1 |
| Karaman, Y | 1 |
| Goktay, A | 1 |
| Agin, H | 1 |
| Karaarslan, U | 1 |
| Kam, PC | 1 |
| Cardone, D | 1 |
3 reviews available for propofol and Mitochondrial Diseases
| Article | Year |
|---|---|
Propofol Is Mitochondrion-Toxic and May Unmask a Mitochondrial Disorder.
Topics: Animals; Humans; Mitochondria; Mitochondrial Diseases; Propofol; Risk | 2016 |
A review of anaesthetic outcomes in patients with genetically confirmed mitochondrial disorders.
Topics: Administration, Inhalation; Administration, Intravenous; Adolescent; Anesthesia, General; Anesthetic | 2017 |
Propofol infusion syndrome.
Topics: Acidosis; Adolescent; Adult; Anesthetics, Intravenous; Biomarkers; Bradycardia; Child; Child, Presch | 2007 |
8 other studies available for propofol and Mitochondrial Diseases
| Article | Year |
|---|---|
Case scenario: Hypotonia in infancy: anesthetic dilemma.
Topics: Acidosis, Lactic; Androstanols; Anesthesia; Anesthetics, Intravenous; Biopsy; Bradycardia; Diagnosis | 2013 |
Propofol-related infusion syndrome heralding a mitochondrial disease: case report.
Topics: Adult; Anesthetics, Intravenous; Arrhythmias, Cardiac; Diagnosis, Differential; Fatal Outcome; Femal | 2013 |
Effect of a single dose of propofol and lack of dextrose administration in a child with mitochondrial disease: a case report.
Topics: Acidosis, Lactic; Adolescent; Blood Pressure; Electroencephalography; Epilepsy; Female; Glucose; Hum | 2014 |
Response to Mtaweh et al.
Topics: Female; Humans; Hypnotics and Sedatives; Mitochondrial Diseases; Propofol | 2014 |
Propofol-related infusion syndrome heralding a mitochondrial disease: case report.
Topics: Arrhythmias, Cardiac; Female; Humans; Mitochondrial Diseases; Propofol; Renal Insufficiency; Rhabdom | 2014 |
Author response.
Topics: Arrhythmias, Cardiac; Female; Humans; Mitochondrial Diseases; Propofol; Renal Insufficiency; Rhabdom | 2014 |
Authors' response to letter to the editor, "Effect of a single dose of propofol and lack of dextrose administration in a child with mitochondrial disease--a case report".
Topics: Female; Humans; Hypnotics and Sedatives; Mitochondrial Diseases; Propofol | 2014 |
Propofol infusion syndrome or adrenoleukodystrophy?
Topics: Acidosis; Anesthetics, Intravenous; Blood Gas Analysis; Cerebral Palsy; Child, Preschool; Female; Hu | 2013 |