propofol has been researched along with Metastase in 15 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propofol-paravertebral anesthesia (PPA) is a unique combination of paravertebral nerve blocks (PVBs) and propofol that regulates the cellular microenvironment during surgical period." | 8.91 | Perioperative propofol-paravertebral anesthesia decreases the metastasis and progression of breast cancer. ( Chen, L; Chen, X; Lu, P; Shen, HY; Tang, JH; Yang, SJ; Yu, DD; Zhang, XH; Zhao, JH; Zhong, SL, 2015) |
| "Propofol, an extensively used intravenous anesthetic agents during cancer resection surgery, has been confirmed to execute anti-tumor effect on multiple cancers, including colorectal cancer (CRC)." | 7.96 | Propofol suppresses proliferation and metastasis of colorectal cancer cells by regulating miR-124-3p.1/AKT3. ( Dong, W; Li, Y; Xiao, G; Yang, H, 2020) |
| " Disease-free survival increases with the use of propofol in combination with epidural anesthesia in patients who undergo surgery for infiltrating bladder cancer." | 5.56 | Anesthesia in Combination with Propofol Increases Disease-Free Survival in Bladder Cancer Patients Who Undergo Radical Tumor Cystectomy as Compared to Inhalational Anesthetics and Opiate-Based Analgesia. ( Cruz Mañas, J; Diaz Crespo, J; Dominguez Recio, ME; Escalona Belmonte, JJ; Fontaneda Heredia, A; Guerrero Orriach, JL; Herrera Imbroda, B; Malo Manso, A; Raigon Ponferrada, A; Ramirez Aliaga, M; Ramirez Fernandez, A; Rubio Navarro, M; Soriano Perez, AM, 2020) |
| "Propofol treatment significantly inhibited cell proliferation, migration and invasion, and reduced the releasing of EMT." | 5.51 | Propofol inhibits proliferation and metastasis by up-regulation of miR-495 in JEG-3 choriocarcinoma cells. ( Sun, H; Wang, Y; Zhang, W, 2019) |
| "Propofol-paravertebral anesthesia (PPA) is a unique combination of paravertebral nerve blocks (PVBs) and propofol that regulates the cellular microenvironment during surgical period." | 4.91 | Perioperative propofol-paravertebral anesthesia decreases the metastasis and progression of breast cancer. ( Chen, L; Chen, X; Lu, P; Shen, HY; Tang, JH; Yang, SJ; Yu, DD; Zhang, XH; Zhao, JH; Zhong, SL, 2015) |
| "Propofol, an extensively used intravenous anesthetic agents during cancer resection surgery, has been confirmed to execute anti-tumor effect on multiple cancers, including colorectal cancer (CRC)." | 3.96 | Propofol suppresses proliferation and metastasis of colorectal cancer cells by regulating miR-124-3p.1/AKT3. ( Dong, W; Li, Y; Xiao, G; Yang, H, 2020) |
| " Disease-free survival increases with the use of propofol in combination with epidural anesthesia in patients who undergo surgery for infiltrating bladder cancer." | 1.56 | Anesthesia in Combination with Propofol Increases Disease-Free Survival in Bladder Cancer Patients Who Undergo Radical Tumor Cystectomy as Compared to Inhalational Anesthetics and Opiate-Based Analgesia. ( Cruz Mañas, J; Diaz Crespo, J; Dominguez Recio, ME; Escalona Belmonte, JJ; Fontaneda Heredia, A; Guerrero Orriach, JL; Herrera Imbroda, B; Malo Manso, A; Raigon Ponferrada, A; Ramirez Aliaga, M; Ramirez Fernandez, A; Rubio Navarro, M; Soriano Perez, AM, 2020) |
| "The apoptosis and metastasis were measured by flow cytometry and transwell assays." | 1.56 | Exosomal lncRNA H19 promotes the progression of hepatocellular carcinoma treated with Propofol via miR-520a-3p/LIMK1 axis. ( Ai, Y; He, J; Liu, J; Wang, D; Xing, N; Yang, J; Yang, T; Zhao, H, 2020) |
| "Propofol treatment significantly inhibited cell proliferation, migration and invasion, and reduced the releasing of EMT." | 1.51 | Propofol inhibits proliferation and metastasis by up-regulation of miR-495 in JEG-3 choriocarcinoma cells. ( Sun, H; Wang, Y; Zhang, W, 2019) |
| "Anesthetics are unavoidable to colorectal cancer (CRC) patients who underwent surgical treatment." | 1.43 | Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application. ( Chen, Y; Deng, F; Ouyang, M; Sun, X; Tang, J; Tao, T; Wang, X; Xu, L; Yao, X; Zhao, L, 2016) |
| "Three weeks later, pulmonary metastasis tumor foci and metastatic inhibitory rate were observed and the expression of E-cadherin and β-catenin in the metastatic tumor tissue were detected by immunohistochemistry." | 1.42 | [Effects of propofol on pulmonary metastasis of intravenously injected MADB106 tumor cells and expression of E-cadherin and β-catenin in rats]. ( Chen, Y; Guo, P; Lin, C; Wang, W; Zhang, Y, 2015) |
| "Pulmonary metastasis of the tumor cells was observed and the expression of MTA1 and Wnt1 in the metastatic tumor detected by immunohistochemistry 3 weeks later." | 1.40 | [Effects of propofol on pulmonary metastasis of intravenous injected tumor cells and expressions of MTA1 and Wnt1 in rats]. ( Chen, Y; Lin, C; Wang, W; Zhang, Y, 2014) |
| "This process has been shown to ablate tumors in animal studies." | 1.36 | Irreversible electroporation: a new challenge in "out of operating theater" anesthesia. ( Ball, C; Kavnoudias, H; Thomson, KR, 2010) |
| "Three weeks later, the lung metastases were counted." | 1.35 | [Effects of neuraxial block and general anesthesia on tumor metastasis in rats]. ( Lai, RC; Li, YP; Lu, YL; Shen, ZW; Wang, XD; Zheng, W, 2008) |
| "Ketamine was most deleterious, and its effects were prevented by peripheral blockade of beta-adrenoceptors combined with low levels of immunostimulation." | 1.32 | Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures. ( Bar-Yosef, S; Ben-Eliyahu, S; Melamed, R; Shakhar, G; Shakhar, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 4 (26.67) | 2.80 |
| Authors | Studies |
|---|---|
| Lai, HC | 1 |
| Lee, MS | 1 |
| Lin, KT | 1 |
| Chan, SM | 1 |
| Chen, JY | 1 |
| Lin, YT | 1 |
| Wu, ZF | 1 |
| Li, Y | 1 |
| Dong, W | 1 |
| Yang, H | 1 |
| Xiao, G | 1 |
| Guerrero Orriach, JL | 1 |
| Raigon Ponferrada, A | 1 |
| Malo Manso, A | 1 |
| Herrera Imbroda, B | 1 |
| Escalona Belmonte, JJ | 1 |
| Ramirez Aliaga, M | 1 |
| Ramirez Fernandez, A | 1 |
| Diaz Crespo, J | 1 |
| Soriano Perez, AM | 1 |
| Fontaneda Heredia, A | 1 |
| Dominguez Recio, ME | 1 |
| Rubio Navarro, M | 1 |
| Cruz Mañas, J | 1 |
| Yu, X | 1 |
| Shi, J | 1 |
| Wang, X | 2 |
| Zhang, F | 1 |
| Wang, D | 1 |
| Xing, N | 1 |
| Yang, T | 1 |
| Liu, J | 1 |
| Zhao, H | 1 |
| He, J | 1 |
| Ai, Y | 1 |
| Yang, J | 1 |
| Perry, NJS | 1 |
| Buggy, D | 1 |
| Ma, D | 1 |
| Sun, H | 1 |
| Wang, Y | 1 |
| Zhang, W | 1 |
| Zhang, Y | 2 |
| Lin, C | 2 |
| Wang, W | 2 |
| Chen, Y | 3 |
| Guo, P | 1 |
| Chen, X | 1 |
| Lu, P | 1 |
| Chen, L | 1 |
| Yang, SJ | 1 |
| Shen, HY | 1 |
| Yu, DD | 1 |
| Zhang, XH | 1 |
| Zhong, SL | 1 |
| Zhao, JH | 1 |
| Tang, JH | 1 |
| Deng, F | 1 |
| Ouyang, M | 1 |
| Yao, X | 1 |
| Tao, T | 1 |
| Sun, X | 1 |
| Xu, L | 1 |
| Tang, J | 1 |
| Zhao, L | 1 |
| Zheng, W | 1 |
| Li, YP | 1 |
| Lai, RC | 1 |
| Lu, YL | 1 |
| Shen, ZW | 1 |
| Wang, XD | 1 |
| Ball, C | 1 |
| Thomson, KR | 1 |
| Kavnoudias, H | 1 |
| Sánchez-Pedrosa, G | 1 |
| Garutti, I | 1 |
| Moraga, FJ | 1 |
| Orozco, HD | 1 |
| Melamed, R | 1 |
| Bar-Yosef, S | 1 |
| Shakhar, G | 1 |
| Shakhar, K | 1 |
| Ben-Eliyahu, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of The Effects Of General Anesthesia and PECS Block Methods on Blood Leukocyte, Neutrophil, Lymphocyte, and Platelet Counts in Patients With Breast Cancer[NCT06151639] | 26 participants (Actual) | Observational | 2022-08-01 | Completed | |||
| Effects of Dexmedetomidine on Anaesthesia During IRE Procedures for Solid Tumours[NCT02044224] | Phase 4 | 30 participants (Anticipated) | Interventional | 2014-01-31 | Completed | ||
| Studio Clinico Pilota Con Uso di Elettroporazione Irreversibile (IRE) Nel Trattamento di Lesioni Neoplastiche Epatiche Con Localizzazione ad accessibilità Limitata o ad Alto Rischio[NCT01442324] | 5 participants (Anticipated) | Interventional | 2011-02-28 | Recruiting | |||
| Impact of Epidural Anesthesia-analgesia on Long-term Outcome in Elderly Patients After Surgery: 5-year Follow-up of a Multicenter Randomized Controlled Trial[NCT03012945] | 1,802 participants (Actual) | Interventional | 2014-11-01 | Completed | |||
| A Prospective, Randomized, Controlled Trial to Compare the Effect of TIVA Propofol vs Sevoflurane Anaesthetic on Serumserum Biomarkers and on PBMCs in Patients Undergoing Breast Cancer Resection Surgery[NCT03005860] | 0 participants (Actual) | Interventional | 2017-01-01 | Withdrawn (stopped due to Funding could not be arranged, so the study was prematurely terminated) | |||
| A Randomized, Open-label Study to Compare Propofol Anesthesia With Sevoflurane Anesthesia in Terms of Overall Survival in Patients With Surgical Intervention for Either Breast-, Colon- or Rectal Cancer[NCT01975064] | Phase 4 | 5,774 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Impact of Epidural Anesthesia-analgesia on Long-term Outcomes in Elderly Patients After Surgery: 5-year Follow-up of a Multicenter Randomized Controlled Trial[NCT03335826] | 1,802 participants (Actual) | Interventional | 2017-08-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for propofol and Metastase
| Article | Year |
|---|---|
Perioperative propofol-paravertebral anesthesia decreases the metastasis and progression of breast cancer.
Topics: Anesthesia; Breast Neoplasms; Female; Humans; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nerve | 2015 |
[Perioperative tumour dissemination. 2. Effects of anaesthesia and analgesia].
Topics: Analgesia; Analgesics; Analgesics, Opioid; Anesthesia; Anesthetics; Humans; Neoplasm Metastasis; Neo | 2012 |
13 other studies available for propofol and Metastase
| Article | Year |
|---|---|
Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in intrahepatic cholangiocarcinoma surgery.
Topics: Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Bile Duct Neoplasms; Cholangiocarcinoma; De | 2019 |
Propofol suppresses proliferation and metastasis of colorectal cancer cells by regulating miR-124-3p.1/AKT3.
Topics: Cell Proliferation; Colorectal Neoplasms; HCT116 Cells; Humans; MicroRNAs; Neoplasm Metastasis; Prop | 2020 |
Anesthesia in Combination with Propofol Increases Disease-Free Survival in Bladder Cancer Patients Who Undergo Radical Tumor Cystectomy as Compared to Inhalational Anesthetics and Opiate-Based Analgesia.
Topics: Analgesics, Opioid; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Intravenous; Cyste | 2020 |
Propofol affects the growth and metastasis of pancreatic cancer via ADAM8.
Topics: ADAM Proteins; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Prol | 2020 |
Exosomal lncRNA H19 promotes the progression of hepatocellular carcinoma treated with Propofol via miR-520a-3p/LIMK1 axis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cocu | 2020 |
Can Anesthesia Influence Cancer Outcomes After Surgery?
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Humans; Immunity, Cellular; | 2019 |
Propofol inhibits proliferation and metastasis by up-regulation of miR-495 in JEG-3 choriocarcinoma cells.
Topics: Bile Duct Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Choriocarci | 2019 |
[Effects of propofol on pulmonary metastasis of intravenous injected tumor cells and expressions of MTA1 and Wnt1 in rats].
Topics: Animals; Immunohistochemistry; Injections, Intravenous; Lung Neoplasms; Male; Neoplasm Metastasis; P | 2014 |
[Effects of propofol on pulmonary metastasis of intravenously injected MADB106 tumor cells and expression of E-cadherin and β-catenin in rats].
Topics: Animals; beta Catenin; Cadherins; Dose-Response Relationship, Drug; Down-Regulation; Immunohistochem | 2015 |
Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application.
Topics: Anesthetics, Intravenous; Animals; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Dexmedetom | 2016 |
[Effects of neuraxial block and general anesthesia on tumor metastasis in rats].
Topics: Anesthesia, Epidural; Anesthesia, General; Animals; Breast Neoplasms; Female; Immunologic Surveillan | 2008 |
Irreversible electroporation: a new challenge in "out of operating theater" anesthesia.
Topics: Acid-Base Imbalance; Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; A | 2010 |
Irreversible electroporation: a new challenge in "out of operating theater" anesthesia.
Topics: Acid-Base Imbalance; Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; A | 2010 |
Irreversible electroporation: a new challenge in "out of operating theater" anesthesia.
Topics: Acid-Base Imbalance; Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; A | 2010 |
Irreversible electroporation: a new challenge in "out of operating theater" anesthesia.
Topics: Acid-Base Imbalance; Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; A | 2010 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |
Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: mediating mechanisms and prophylactic measures.
Topics: Adjuvants, Immunologic; Adrenergic beta-Antagonists; Anesthetics; Anesthetics, Dissociative; Anesthe | 2003 |