propofol has been researched along with Metabolic Acidosis in 81 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compared acid-base and biochemical changes and quality of recovery in male cats with experimentally induced urethral obstruction and anesthetized with either propofol or a combination of ketamine and diazepam for urethral catheterization." | 9.16 | Acid-base and biochemical stabilization and quality of recovery in male cats with urethral obstruction and anesthetized with propofol or a combination of ketamine and diazepam. ( Carregaro, AB; da Cunha, JP; da Cunha, MG; Freitas, GC; Gomes, K; Pippi, NL; Togni, M, 2012) |
| "There is both in vitro and clinical evidence that high-dose propofol can inhibit mitochondrial respiration, resulting in metabolic acidosis." | 9.13 | Stewart's physicochemical approach in neurosurgical patients with hyperchloremic metabolic acidosis during propofol anesthesia. ( Choi, JJ; Kim, JY; Kwak, HJ; Lee, D; Lee, KC, 2008) |
| " Keywords were propofol, propofol infusion syndrome (PRIS), rhabdomyolysis, heart failure, arrhythmias, metabolic acidosis, brain injury, sedation, intensive care." | 8.86 | [Propofol infusion syndrome]. ( Greff, B; Laquay, N; Meyer, P; Orliaguet, G; Prieur, S, 2010) |
| "Propofol infusion syndrome (PRIS) is defined as acute bradycardia progressing to asystole combined with lipemic plasma, fatty liver enlargement, metabolic acidosis with negative base excess >10 mmol l(-1), rhabdomyolysis or myoglobinuria associated with propofol infusion." | 8.85 | Propofol infusion syndrome: update of clinical manifestation and pathophysiology. ( Bein, B; Fudickar, A, 2009) |
| "The clinical features of propofol infusion syndrome (PRIS) are acute refractory bradycardia leading to asystole, in the presence of one or more of the following: metabolic acidosis (base deficit > 10 mmol." | 8.84 | Propofol infusion syndrome. ( Cardone, D; Kam, PC, 2007) |
| "Propofol infusion syndrome is a rare but often fatal syndrome, characterized by lactacidosis, lipaemic plasma and cardiac failure, associated with propofol infusion over prolonged periods of time." | 8.83 | Propofol infusion syndrome in anaesthesia and intensive care medicine. ( Bein, B; Fudickar, A; Tonner, PH, 2006) |
| "All patients on the KD who underwent anesthesia with propofol between 2012 and 2022 were reviewed." | 8.31 | Propofol for Anesthesia in Pediatric Patients With Epilepsy on the Ketogenic Diet: A Single-Center Experience. ( Bui, PH; Diaz-Medina, G; Handoko, M; Katyayan, A; Ng, AS, 2023) |
| "To this day, the pathophysiology and risk factors of propofol infusion syndrome (PRIS) remain unknown." | 7.96 | Suspected propofol infusion syndrome during normal targeted propofol concentration. ( Ichikawa, T; Kamata, K; Masui, K; Okuyama, K; Ozaki, M, 2020) |
| "Patients receiving midazolam had a more than doubled risk of respiratory depression as mirrored by hypercapnia and acidosis, but not hypoxemia." | 7.88 | Midazolam addition to analgosedation for pulmonary vein isolation may increase risk of hypercapnia and acidosis. ( Bürkle, G; Ehrlich, JR; Feurich, F; Kaess, BM, 2018) |
| "Propofol infusion syndrome (PIS) is defined by arrhythmia, rhabdomyolysis, lactic acidosis, and unrecognized leads to death." | 7.80 | Propofol infusion syndrome: a lethal condition in critically injured patients eliminated by a simple screening protocol. ( Clement, LP; Croce, MA; Fabian, TC; Fischer, PE; Lee, M; Magnotti, LJ; Schroeppel, TJ; Sharpe, JP, 2014) |
| "Propofol infusion syndrome (PRIS) is well known, often associated with, lethal complication of sedation with propofol." | 7.78 | Propofol infusion syndrome heralded by ECG changes. ( Aslan, A; Jacobs, B; Mijzen, EJ; Rodgers, MG, 2012) |
| "In propofol radiofrequency ablation patients with no apparent cause of metabolic acidosis besides propofol, 13 of 55 (24%) had base excess of -2 or less, versus 22 of 267 carotid patients (8." | 7.74 | Incidence of propofol infusion syndrome during noninvasive radiofrequency ablation for atrial flutter or fibrillation. ( Cravens, GT; Johnson, ME; Packer, DL, 2007) |
| "Propofol is increasingly used for the treatment of status epilepticus due to the ease of use and tolerability, even if safety data from randomized clinical trials are lacking." | 7.74 | Propofol-associated fatal myocardial failure and rhabdomyolysis in an adult with status epilepticus. ( Harris, BT; Jobst, BC; Zarovnaya, EL, 2007) |
| "The authors report a case of short-term high-dose propofol-related metabolic acidosis in a 3-year-old girl." | 7.74 | Early propofol infusion syndrome following cerebral angiographic embolization for giant aneurysm repair. Case report. ( Muhonen, MG; Nwagwu, CI; Westhout, FD, 2007) |
| "The occurrence of metabolic acidosis, rhabdomyolysis, hyperkalemia, and sudden cardiac death after long-term, high-dose propofol infusion has been referred to as propofol infusion syndrome (PRIS)." | 7.73 | Electrocardiographic changes predicting sudden death in propofol-related infusion syndrome. ( Antzelevitch, C; Brugada, R; Cremer, OL; Crijns, HJ; Delhaas, T; Di Diego, JM; Kalkman, CJ; Oliva, A; Prinzen, FW; Rodriguez, LM; Timmermans, C; Vernooy, K; Volders, PG, 2006) |
| "These data show an association between extended propofol use and metabolic acidosis, rhabdomyolysis, and death in adults, as well as children." | 7.73 | The syndrome of irreversible acidosis after prolonged propofol infusion. ( Abou-Khaled, KJ; Kumar, MA; Schwartzman, RJ; Thomas, CE; Urrutia, VC, 2005) |
| "Propofol-induced metabolic acidosis is well recognised in the paediatric literature, but the existence of such a syndrome in adults remains contentious." | 7.73 | Short-term low-dose propofol anaesthesia associated with severe metabolic acidosis. ( Chukwuemeka, A; Ko, R; Ralph-Edwards, A, 2006) |
| "The propofol infusion syndrome is a rare but potentially lethal complication resulting from a prolonged continuous administration of propofol." | 7.73 | [Propofol infusion syndrome]. ( Jost, R; Likar, R; Oher, M; Pointner, I; Schalk, HV; Trampitsch, E, 2006) |
| "Propofol is used for the treatment of refractory status epilepticus." | 7.72 | Fatal propofol infusion syndrome in association with ketogenic diet. ( Baumeister, FA; Eberhardt, J; Holthausen, H; Kunkel, J; Liebhaber, GM; Oberhoffer, R; Peters, J, 2004) |
| "Propofol infusion syndrome has been increasingly recognized as a syndrome of unexplained myocardial failure, metabolic acidosis, and rhabdomyolysis with renal failure." | 7.72 | Propofol infusion syndrome: an unusual cause of renal failure. ( Casserly, B; Eisele, G; Haqqie, S; O'Mahony, E; Timm, EG; Urizar, R, 2004) |
| "The authors present the hospital course of a 13-year-old girl with a closed head injury who received a prolonged infusion of propofol for sedation and, subsequently, died as a result of severe metabolic acidosis, rhabdomyolysis, and cardiovascular collapse." | 7.71 | Metabolic acidosis, rhabdomyolysis, and cardiovascular collapse after prolonged propofol infusion. ( Bauman, LA; Cannon, ML; Glazier, SS, 2001) |
| "Propofol infusion syndrome is a rare but frequently fatal complication in critically ill children given long-term propofol infusions." | 7.71 | Impaired fatty acid oxidation in propofol infusion syndrome. ( Segar, P; Shield, J; Stone, J; Weir, P; Wolf, A, 2001) |
| " Furthermore, the safe dosage of propofol may need re-evaluation, and new studies are needed." | 6.44 | Propofol infusion syndrome: an overview of a perplexing disease. ( Fodale, V; La Monaca, E, 2008) |
| "Propofol is a short-acting intravenous anesthetic agent widely used for sedation in anesthesia and intensive care." | 6.44 | The propofol infusion 'syndrome' in intensive care unit: from pathophysiology to prophylaxis and treatment. ( Dragoumanis, C; Papaioannou, V; Pneumatikos, I; Theodorou, V, 2008) |
| "During this period 44 children with respiratory tract infections had been admitted to this unit and sedated for at least 48 h." | 6.40 | Propofol infusion syndrome in children. ( Bray, RJ, 1998) |
| "Propofol was utilized as part of the anesthetic protocol." | 5.48 | Propofol infusion-like syndrome in a dog. ( Mallard, JM; Peterson, NW; Rieser, TM, 2018) |
| "Propofol infusion syndrome is a rare but frequently fatal complication in critically ill children who are given prolonged high-dose infusions of the drug." | 5.34 | Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injury. ( Coritsidis, G; Rehman, Z; Sabsovich, I; Yunen, J, 2007) |
| "Five children with upper respiratory tract infections aged between 4 weeks and 6 years." | 5.28 | Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports. ( Bray, RJ; Greenaway, CL; Parke, TJ; Rice, AS; Smith, PJ; Stevens, JE; Verghese, C; Waldmann, CS, 1992) |
| "This study compared acid-base and biochemical changes and quality of recovery in male cats with experimentally induced urethral obstruction and anesthetized with either propofol or a combination of ketamine and diazepam for urethral catheterization." | 5.16 | Acid-base and biochemical stabilization and quality of recovery in male cats with urethral obstruction and anesthetized with propofol or a combination of ketamine and diazepam. ( Carregaro, AB; da Cunha, JP; da Cunha, MG; Freitas, GC; Gomes, K; Pippi, NL; Togni, M, 2012) |
| "There is both in vitro and clinical evidence that high-dose propofol can inhibit mitochondrial respiration, resulting in metabolic acidosis." | 5.13 | Stewart's physicochemical approach in neurosurgical patients with hyperchloremic metabolic acidosis during propofol anesthesia. ( Choi, JJ; Kim, JY; Kwak, HJ; Lee, D; Lee, KC, 2008) |
| " Keywords were propofol, propofol infusion syndrome (PRIS), rhabdomyolysis, heart failure, arrhythmias, metabolic acidosis, brain injury, sedation, intensive care." | 4.86 | [Propofol infusion syndrome]. ( Greff, B; Laquay, N; Meyer, P; Orliaguet, G; Prieur, S, 2010) |
| "Propofol infusion syndrome (PRIS) is defined as acute bradycardia progressing to asystole combined with lipemic plasma, fatty liver enlargement, metabolic acidosis with negative base excess >10 mmol l(-1), rhabdomyolysis or myoglobinuria associated with propofol infusion." | 4.85 | Propofol infusion syndrome: update of clinical manifestation and pathophysiology. ( Bein, B; Fudickar, A, 2009) |
| "The clinical features of propofol infusion syndrome (PRIS) are acute refractory bradycardia leading to asystole, in the presence of one or more of the following: metabolic acidosis (base deficit > 10 mmol." | 4.84 | Propofol infusion syndrome. ( Cardone, D; Kam, PC, 2007) |
| "Propofol infusion syndrome is a rare but often fatal syndrome, characterized by lactacidosis, lipaemic plasma and cardiac failure, associated with propofol infusion over prolonged periods of time." | 4.83 | Propofol infusion syndrome in anaesthesia and intensive care medicine. ( Bein, B; Fudickar, A; Tonner, PH, 2006) |
| "All patients on the KD who underwent anesthesia with propofol between 2012 and 2022 were reviewed." | 4.31 | Propofol for Anesthesia in Pediatric Patients With Epilepsy on the Ketogenic Diet: A Single-Center Experience. ( Bui, PH; Diaz-Medina, G; Handoko, M; Katyayan, A; Ng, AS, 2023) |
| "To this day, the pathophysiology and risk factors of propofol infusion syndrome (PRIS) remain unknown." | 3.96 | Suspected propofol infusion syndrome during normal targeted propofol concentration. ( Ichikawa, T; Kamata, K; Masui, K; Okuyama, K; Ozaki, M, 2020) |
| "Patients receiving midazolam had a more than doubled risk of respiratory depression as mirrored by hypercapnia and acidosis, but not hypoxemia." | 3.88 | Midazolam addition to analgosedation for pulmonary vein isolation may increase risk of hypercapnia and acidosis. ( Bürkle, G; Ehrlich, JR; Feurich, F; Kaess, BM, 2018) |
| "Propofol infusion syndrome (PIS) is defined by arrhythmia, rhabdomyolysis, lactic acidosis, and unrecognized leads to death." | 3.80 | Propofol infusion syndrome: a lethal condition in critically injured patients eliminated by a simple screening protocol. ( Clement, LP; Croce, MA; Fabian, TC; Fischer, PE; Lee, M; Magnotti, LJ; Schroeppel, TJ; Sharpe, JP, 2014) |
| "Following a propofol anesthetic, a 5-year-old girl with lower extremity spasticity seized and developed hypertriglyceridemia, hyperkalemia, and metabolic acidosis." | 3.79 | Propofol infusion syndrome or adrenoleukodystrophy? ( Agin, H; Goktay, A; Karaarslan, U; Karaman, Y, 2013) |
| "Propofol infusion syndrome (PRIS) is well known, often associated with, lethal complication of sedation with propofol." | 3.78 | Propofol infusion syndrome heralded by ECG changes. ( Aslan, A; Jacobs, B; Mijzen, EJ; Rodgers, MG, 2012) |
| "The mortality rates in the present study were extremely high; further hypotension and elevations in plasma pro-inflammatory and anti-inflammatory cytokine concentrations after endotoxin injection were not attenuated by mild hyperthermia between 39 °C and 40 °C, but they were attenuated by propofol with mild hyperthermia." | 3.78 | Effects of propofol with hyperthermia in a rat model of endotoxemic shock. ( Mukawa, C; Taniguchi, T, 2012) |
| " Plasma protein binding ratio of propofol in plasma samples of rats with ketoacidosis tended to be lower than those of normal rats samples." | 3.75 | [Basic study on the mechanism of postanesthetic recovery acceleration caused by infusion of bicarbonated Ringer's solution]. ( Kokuba, Y; Koyama, T; Mori, S; Ogawa, T; Satoh, K, 2009) |
| "In propofol radiofrequency ablation patients with no apparent cause of metabolic acidosis besides propofol, 13 of 55 (24%) had base excess of -2 or less, versus 22 of 267 carotid patients (8." | 3.74 | Incidence of propofol infusion syndrome during noninvasive radiofrequency ablation for atrial flutter or fibrillation. ( Cravens, GT; Johnson, ME; Packer, DL, 2007) |
| "The authors report a case of short-term high-dose propofol-related metabolic acidosis in a 3-year-old girl." | 3.74 | Early propofol infusion syndrome following cerebral angiographic embolization for giant aneurysm repair. Case report. ( Muhonen, MG; Nwagwu, CI; Westhout, FD, 2007) |
| "Propofol is increasingly used for the treatment of status epilepticus due to the ease of use and tolerability, even if safety data from randomized clinical trials are lacking." | 3.74 | Propofol-associated fatal myocardial failure and rhabdomyolysis in an adult with status epilepticus. ( Harris, BT; Jobst, BC; Zarovnaya, EL, 2007) |
| "These data show an association between extended propofol use and metabolic acidosis, rhabdomyolysis, and death in adults, as well as children." | 3.73 | The syndrome of irreversible acidosis after prolonged propofol infusion. ( Abou-Khaled, KJ; Kumar, MA; Schwartzman, RJ; Thomas, CE; Urrutia, VC, 2005) |
| "High-dose propofol infusion for sedation of patients in the intensive care unit can result in rhabdomyolysis, acute renal failure, metabolic acidosis, hyperkalemia, ventricular arrhythmia, hyperthermia, and death." | 3.73 | A lethal complication of propofol. ( Chavez, VM; Haake, RJ; Hayat, SA; Suen, HC, 2006) |
| "The occurrence of metabolic acidosis, rhabdomyolysis, hyperkalemia, and sudden cardiac death after long-term, high-dose propofol infusion has been referred to as propofol infusion syndrome (PRIS)." | 3.73 | Electrocardiographic changes predicting sudden death in propofol-related infusion syndrome. ( Antzelevitch, C; Brugada, R; Cremer, OL; Crijns, HJ; Delhaas, T; Di Diego, JM; Kalkman, CJ; Oliva, A; Prinzen, FW; Rodriguez, LM; Timmermans, C; Vernooy, K; Volders, PG, 2006) |
| "The propofol infusion syndrome is a rare but potentially lethal complication resulting from a prolonged continuous administration of propofol." | 3.73 | [Propofol infusion syndrome]. ( Jost, R; Likar, R; Oher, M; Pointner, I; Schalk, HV; Trampitsch, E, 2006) |
| "Propofol-induced metabolic acidosis is well recognised in the paediatric literature, but the existence of such a syndrome in adults remains contentious." | 3.73 | Short-term low-dose propofol anaesthesia associated with severe metabolic acidosis. ( Chukwuemeka, A; Ko, R; Ralph-Edwards, A, 2006) |
| "Propofol infusion syndrome has been increasingly recognized as a syndrome of unexplained myocardial failure, metabolic acidosis, and rhabdomyolysis with renal failure." | 3.72 | Propofol infusion syndrome: an unusual cause of renal failure. ( Casserly, B; Eisele, G; Haqqie, S; O'Mahony, E; Timm, EG; Urizar, R, 2004) |
| "Propofol is used for the treatment of refractory status epilepticus." | 3.72 | Fatal propofol infusion syndrome in association with ketogenic diet. ( Baumeister, FA; Eberhardt, J; Holthausen, H; Kunkel, J; Liebhaber, GM; Oberhoffer, R; Peters, J, 2004) |
| "This case report discusses the cause of death in a 3-year-old child who survived a high dose (20 mg x kg-1 x h-1) of propofol, infused over a period of 15 h, following which the patient developed a combined respiratory and metabolic acidosis, the oxygenation remaining normal." | 3.72 | Death after re-exposure to propofol in a 3-year-old child: a case report. ( Aring, C; Gillor, A; Holzki, J, 2004) |
| " Administration of propofol via continuous intravenous infusion was not associated with metabolic acidosis or hemodynamic compromise." | 3.71 | Continuous propofol infusion in 142 critically ill children. ( Cornfield, DN; Milla, CE; Nelson, MD; Sweeney, M; Tegtmeyer, K, 2002) |
| "Propofol infusion syndrome is a rare but frequently fatal complication in critically ill children given long-term propofol infusions." | 3.71 | Impaired fatty acid oxidation in propofol infusion syndrome. ( Segar, P; Shield, J; Stone, J; Weir, P; Wolf, A, 2001) |
| "The authors present the hospital course of a 13-year-old girl with a closed head injury who received a prolonged infusion of propofol for sedation and, subsequently, died as a result of severe metabolic acidosis, rhabdomyolysis, and cardiovascular collapse." | 3.71 | Metabolic acidosis, rhabdomyolysis, and cardiovascular collapse after prolonged propofol infusion. ( Bauman, LA; Cannon, ML; Glazier, SS, 2001) |
| "Propofol does not increase complications even in a collective with pre-existing impairment of LVEF." | 2.79 | Minimal and deep sedation during ablation of ventricular tachycardia. ( Attanasio, P; Blaschke, F; Boldt, LH; Haverkamp, W; Huemer, M; Loehr, L; Mueller, A; Parwani, AS; Storm, C; Wutzler, A, 2014) |
| "Metabolic acidosis is regarded as an early warning sign of PRIS." | 2.78 | Effect of propofol and sevoflurane on acid-base balance during pediatric heart catheterization. ( Bein, B; Dütschke, P; Ensenauer, R; Fischer, G; Fudickar, A; Smigaj, K; Steinfath, M, 2013) |
| "Propofol is a potent intravenous anesthetic agent that rapidly induces sedation and unconsciousness." | 2.47 | Clinical effects and lethal and forensic aspects of propofol. ( Levy, RJ, 2011) |
| " Furthermore, the safe dosage of propofol may need re-evaluation, and new studies are needed." | 2.44 | Propofol infusion syndrome: an overview of a perplexing disease. ( Fodale, V; La Monaca, E, 2008) |
| "Propofol is a short-acting intravenous anesthetic agent widely used for sedation in anesthesia and intensive care." | 2.44 | The propofol infusion 'syndrome' in intensive care unit: from pathophysiology to prophylaxis and treatment. ( Dragoumanis, C; Papaioannou, V; Pneumatikos, I; Theodorou, V, 2008) |
| "During this period 44 children with respiratory tract infections had been admitted to this unit and sedated for at least 48 h." | 2.40 | Propofol infusion syndrome in children. ( Bray, RJ, 1998) |
| " The propofol infusion rate and cumulative propofol dosage (under 140 mg/kg) were well below levels associated with PRIS." | 1.91 | Unusual case of propofol-related infusion syndrome complicating severe COVID-19 ARDS. ( Babu, VK; Garcia-Fernandez, A; Perez Del Nogal, G; Rojas, P, 2023) |
| "Propofol was utilized as part of the anesthetic protocol." | 1.48 | Propofol infusion-like syndrome in a dog. ( Mallard, JM; Peterson, NW; Rieser, TM, 2018) |
| "We reviewed all patients with severe head trauma admitted to our Neuro-Intensive Care Unit over a 4-year period for use of propofol and vasopressors." | 1.35 | Vasopressors and propofol infusion syndrome in severe head trauma. ( Sinson, G; Smith, H; Varelas, P, 2009) |
| "Propofol infusion syndrome is a rare but frequently fatal complication in critically ill children who are given prolonged high-dose infusions of the drug." | 1.34 | Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injury. ( Coritsidis, G; Rehman, Z; Sabsovich, I; Yunen, J, 2007) |
| "Propofol was stopped." | 1.32 | A case of propofol toxicity: further evidence for a causal mechanism. ( Al Ayed, T; Decell, MK; Withington, DE, 2004) |
| "The patient developed cardiac arrhythmia, metabolic acidosis, and cardiac failure, which resulted in death." | 1.31 | Death related to propofol use in an adult patient. ( Baerga-Varela, Y; Murray, MJ; Perrier, ND, 2000) |
| "Five children with upper respiratory tract infections aged between 4 weeks and 6 years." | 1.28 | Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports. ( Bray, RJ; Greenaway, CL; Parke, TJ; Rice, AS; Smith, PJ; Stevens, JE; Verghese, C; Waldmann, CS, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (12.35) | 18.2507 |
| 2000's | 51 (62.96) | 29.6817 |
| 2010's | 17 (20.99) | 24.3611 |
| 2020's | 3 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Babu, VK | 1 |
| Rojas, P | 1 |
| Perez Del Nogal, G | 1 |
| Garcia-Fernandez, A | 1 |
| Bui, PH | 1 |
| Handoko, M | 1 |
| Diaz-Medina, G | 1 |
| Ng, AS | 1 |
| Katyayan, A | 1 |
| Ichikawa, T | 1 |
| Okuyama, K | 1 |
| Kamata, K | 1 |
| Masui, K | 1 |
| Ozaki, M | 1 |
| Kaess, BM | 1 |
| Feurich, F | 1 |
| Bürkle, G | 1 |
| Ehrlich, JR | 1 |
| Mallard, JM | 1 |
| Rieser, TM | 1 |
| Peterson, NW | 1 |
| Fudickar, A | 3 |
| Smigaj, K | 1 |
| Ensenauer, R | 1 |
| Fischer, G | 1 |
| Dütschke, P | 1 |
| Steinfath, M | 1 |
| Bein, B | 3 |
| Schroeppel, TJ | 1 |
| Fabian, TC | 1 |
| Clement, LP | 1 |
| Fischer, PE | 1 |
| Magnotti, LJ | 1 |
| Sharpe, JP | 1 |
| Lee, M | 1 |
| Croce, MA | 1 |
| Wutzler, A | 1 |
| Mueller, A | 1 |
| Loehr, L | 1 |
| Huemer, M | 1 |
| Parwani, AS | 1 |
| Attanasio, P | 1 |
| Blaschke, F | 1 |
| Storm, C | 1 |
| Boldt, LH | 1 |
| Haverkamp, W | 1 |
| Rayadurg, V | 1 |
| Uttarwar, A | 1 |
| Surve, R | 1 |
| Zaccheo, MM | 1 |
| Bucher, DH | 1 |
| Papaioannou, V | 1 |
| Dragoumanis, C | 1 |
| Theodorou, V | 1 |
| Pneumatikos, I | 1 |
| Smith, H | 1 |
| Sinson, G | 1 |
| Varelas, P | 1 |
| Satoh, K | 1 |
| Koyama, T | 1 |
| Ogawa, T | 1 |
| Mori, S | 1 |
| Kokuba, Y | 1 |
| Shoemaker, JD | 1 |
| Laquay, N | 1 |
| Prieur, S | 1 |
| Greff, B | 1 |
| Meyer, P | 1 |
| Orliaguet, G | 1 |
| Devlin, JW | 1 |
| Mallow-Corbett, S | 1 |
| Riker, RR | 1 |
| Levy, RJ | 1 |
| Testerman, GM | 1 |
| Chow, TT | 1 |
| Easparam, S | 1 |
| Annecke, T | 1 |
| Conzen, P | 1 |
| Ney, L | 1 |
| Mukawa, C | 1 |
| Taniguchi, T | 1 |
| Mijzen, EJ | 1 |
| Jacobs, B | 1 |
| Aslan, A | 1 |
| Rodgers, MG | 1 |
| Freitas, GC | 1 |
| da Cunha, MG | 1 |
| Gomes, K | 1 |
| da Cunha, JP | 1 |
| Togni, M | 1 |
| Pippi, NL | 1 |
| Carregaro, AB | 1 |
| Karaman, Y | 1 |
| Goktay, A | 1 |
| Agin, H | 1 |
| Karaarslan, U | 1 |
| Ngamprasertwong, P | 1 |
| Michelfelder, EC | 1 |
| Arbabi, S | 1 |
| Choi, YS | 1 |
| Statile, C | 1 |
| Ding, L | 1 |
| Boat, A | 1 |
| Eghtesady, P | 1 |
| Holland, K | 1 |
| Sadhasivam, S | 1 |
| Wooltorton, E | 1 |
| Cornfield, DN | 1 |
| Tegtmeyer, K | 1 |
| Nelson, MD | 1 |
| Milla, CE | 1 |
| Sweeney, M | 1 |
| Ozlü, O | 1 |
| Ozkara, HA | 1 |
| Eris, S | 1 |
| Ocal, T | 1 |
| Crawford, MW | 1 |
| Dodgson, BG | 1 |
| Holtby, HH | 1 |
| Roy, WL | 1 |
| Cray, SH | 1 |
| Pettifer, RJ | 1 |
| Belanger, MP | 1 |
| Askin, N | 1 |
| Bandali, K | 1 |
| Wallen, WJ | 1 |
| Wittnich, C | 1 |
| Holzki, J | 1 |
| Aring, C | 1 |
| Gillor, A | 1 |
| Withington, DE | 1 |
| Decell, MK | 1 |
| Al Ayed, T | 1 |
| Funston, JS | 1 |
| Prough, DS | 1 |
| Burow, BK | 1 |
| Johnson, ME | 2 |
| Packer, DL | 2 |
| Baumeister, FA | 1 |
| Oberhoffer, R | 1 |
| Liebhaber, GM | 1 |
| Kunkel, J | 1 |
| Eberhardt, J | 1 |
| Holthausen, H | 1 |
| Peters, J | 1 |
| Casserly, B | 1 |
| O'Mahony, E | 1 |
| Timm, EG | 1 |
| Haqqie, S | 1 |
| Eisele, G | 1 |
| Urizar, R | 1 |
| Farag, E | 1 |
| Deboer, G | 1 |
| Cohen, BH | 1 |
| Niezgoda, J | 1 |
| Machata, AM | 1 |
| Gonano, C | 1 |
| Bîrsan, T | 1 |
| Zimpfer, M | 1 |
| Spiss, CK | 1 |
| Kumar, MA | 1 |
| Urrutia, VC | 1 |
| Thomas, CE | 1 |
| Abou-Khaled, KJ | 1 |
| Schwartzman, RJ | 1 |
| Suen, HC | 1 |
| Haake, RJ | 1 |
| Chavez, VM | 1 |
| Hayat, SA | 1 |
| Wessel, N | 1 |
| Schirdewan, A | 1 |
| Vernooy, K | 1 |
| Delhaas, T | 1 |
| Cremer, OL | 1 |
| Di Diego, JM | 1 |
| Oliva, A | 1 |
| Timmermans, C | 1 |
| Volders, PG | 1 |
| Prinzen, FW | 1 |
| Crijns, HJ | 1 |
| Antzelevitch, C | 1 |
| Kalkman, CJ | 1 |
| Rodriguez, LM | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Observer Rating Scale of Facial Expression Can Predict Dreaming in Propofol Anesthesia[NCT04235894] | 124 participants (Actual) | Observational | 2016-09-07 | Completed | |||
| Keto-diet for Intubated Critical Care COVID-19 (KICC-COVID19)[NCT04358835] | 0 participants (Actual) | Interventional | 2020-09-01 | Withdrawn (stopped due to Study did not begin enrollment, multiple competing studies at same institution) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for propofol and Metabolic Acidosis
| Article | Year |
|---|---|
Propofol infusion syndrome: a rare complication with potentially fatal results.
Topics: Acidosis; Acute Kidney Injury; Adult; Anesthetics, Intravenous; Arrhythmias, Cardiac; Critical Care; | 2008 |
The propofol infusion 'syndrome' in intensive care unit: from pathophysiology to prophylaxis and treatment.
Topics: Acidosis; Adult; Anesthetics, Intravenous; Cardiovascular Diseases; Child; Heart; Humans; Hyperkalem | 2008 |
Propofol infusion syndrome: update of clinical manifestation and pathophysiology.
Topics: Acidosis; Acute Disease; Adult; Age Factors; Anesthetics, Intravenous; Animals; Bradycardia; Brain I | 2009 |
[Propofol infusion syndrome].
Topics: Acidosis; Arrhythmias, Cardiac; Heart Failure; Humans; Hypnotics and Sedatives; Infusions, Intraveno | 2010 |
Adverse drug events associated with the use of analgesics, sedatives, and antipsychotics in the intensive care unit.
Topics: Acidosis; Analgesics; Antipsychotic Agents; Bradycardia; Cardiovascular Diseases; Critical Care; Dru | 2010 |
Clinical effects and lethal and forensic aspects of propofol.
Topics: Accidents; Acidosis; Acute Kidney Injury; Bacteremia; Bradycardia; Drug Overdose; Dyslipidemias; For | 2011 |
Propofol infusion syndrome in anaesthesia and intensive care medicine.
Topics: Acidosis; Anesthesia; Anesthetics, Intravenous; Critical Care; Heart Failure; Humans; Hyperlipidemia | 2006 |
Reports of death with use of propofol (Diprivan) for nonprocedural (long-term) sedation and literature review.
Topics: Acidosis; Adult; Adverse Drug Reaction Reporting Systems; Cardiovascular System; Child; Humans; Hypn | 2006 |
Propofol infusion syndrome.
Topics: Acidosis; Adolescent; Adult; Anesthetics, Intravenous; Biomarkers; Bradycardia; Child; Child, Presch | 2007 |
Propofol infusion syndrome: an overview of a perplexing disease.
Topics: Acidosis; Anesthetics, Intravenous; Arrhythmias, Cardiac; Heart Failure; Hepatomegaly; Humans; Hypno | 2008 |
Propofol infusion syndrome in children.
Topics: Acidosis; Child; Child, Preschool; Female; Heart Diseases; Humans; Hypnotics and Sedatives; Infant; | 1998 |
5 trials available for propofol and Metabolic Acidosis
| Article | Year |
|---|---|
Effect of propofol and sevoflurane on acid-base balance during pediatric heart catheterization.
Topics: Acid-Base Equilibrium; Acidosis; Adolescent; Anesthetics, Inhalation; Anesthetics, Intravenous; Bloo | 2013 |
Minimal and deep sedation during ablation of ventricular tachycardia.
Topics: Acidosis; Adult; Aged; Bradycardia; Catheter Ablation; Conscious Sedation; Deep Sedation; Feasibilit | 2014 |
Acid-base and biochemical stabilization and quality of recovery in male cats with urethral obstruction and anesthetized with propofol or a combination of ketamine and diazepam.
Topics: Acid-Base Equilibrium; Acidosis; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, D | 2012 |
Propofol anaesthesia and metabolic acidosis in children.
Topics: Acidosis; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Gas Analysis; Child; Child, Presc | 2003 |
Stewart's physicochemical approach in neurosurgical patients with hyperchloremic metabolic acidosis during propofol anesthesia.
Topics: Acid-Base Equilibrium; Acidosis; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pressure; | 2008 |
65 other studies available for propofol and Metabolic Acidosis
| Article | Year |
|---|---|
Unusual case of propofol-related infusion syndrome complicating severe COVID-19 ARDS.
Topics: Acidosis; Aged; COVID-19; Humans; Hyperlipidemias; Hypertriglyceridemia; Male; Propofol; Propofol In | 2023 |
Propofol for Anesthesia in Pediatric Patients With Epilepsy on the Ketogenic Diet: A Single-Center Experience.
Topics: Acidosis; Anesthesia; Anesthetics; Anesthetics, Intravenous; Child; Diet, Ketogenic; Epilepsy; Human | 2023 |
Suspected propofol infusion syndrome during normal targeted propofol concentration.
Topics: Acidosis; Acidosis, Lactic; Adult; Anesthetics, Intravenous; Child; Humans; Infusions, Intravenous; | 2020 |
Midazolam addition to analgosedation for pulmonary vein isolation may increase risk of hypercapnia and acidosis.
Topics: Acidosis; Aged; Anesthetics, Intravenous; Drug Therapy, Combination; Female; Fentanyl; Follow-Up Stu | 2018 |
Propofol infusion-like syndrome in a dog.
Topics: Acidosis; Acute Kidney Injury; Animals; Arrhythmias, Cardiac; Dog Diseases; Dogs; Female; Hypnotics | 2018 |
Propofol infusion syndrome: a lethal condition in critically injured patients eliminated by a simple screening protocol.
Topics: Acidosis; Acute Kidney Injury; Adult; Anesthetics, Intravenous; Arrhythmias, Cardiac; Cohort Studies | 2014 |
Is Propofol Safe in Patients With Phenylketonuria?
Topics: Acidosis; Anesthesia, Intravenous; Anesthetics, Intravenous; Brain; Deep Sedation; Humans; Infant; M | 2018 |
Vasopressors and propofol infusion syndrome in severe head trauma.
Topics: Acidosis; Adult; Aged; Aged, 80 and over; Combined Modality Therapy; Craniocerebral Trauma; Creatine | 2009 |
[Basic study on the mechanism of postanesthetic recovery acceleration caused by infusion of bicarbonated Ringer's solution].
Topics: Acidosis; Anesthesia Recovery Period; Animals; Infusions, Intravenous; Isotonic Solutions; Male; Pro | 2009 |
Diethylene glycol in propofol infusion syndrome?
Topics: Acidosis; Anesthetics, Intravenous; Drug Contamination; Ethylene Glycols; Humans; Hypnotics and Seda | 2010 |
Propofol infusion syndrome: an algorithm for prevention.
Topics: Acidosis; Acute Kidney Injury; Adolescent; Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; | 2011 |
Propofol-related infusion syndrome induced by "moderate dosage" in a patient with severe head trauma.
Topics: Acidosis; Adult; Anesthetics, Intravenous; Craniocerebral Trauma; Dose-Response Relationship, Drug; | 2012 |
Effects of propofol with hyperthermia in a rat model of endotoxemic shock.
Topics: Acidosis; Animals; Carbon Dioxide; Combined Modality Therapy; Cytokines; Drug Evaluation, Preclinica | 2012 |
Propofol infusion syndrome heralded by ECG changes.
Topics: Acidosis; Brain Injuries; Electrocardiography; Humans; Hypnotics and Sedatives; Intracranial Hyperte | 2012 |
Propofol infusion syndrome or adrenoleukodystrophy?
Topics: Acidosis; Anesthetics, Intravenous; Blood Gas Analysis; Cerebral Palsy; Child, Preschool; Female; Hu | 2013 |
Anesthetic techniques for fetal surgery: effects of maternal anesthesia on intraoperative fetal outcomes in a sheep model.
Topics: Acid-Base Equilibrium; Acidosis; Anesthesia, Obstetrical; Anesthetics, Combined; Anesthetics, Inhala | 2013 |
Propofol: contraindicated for sedation of pediatric intensive care patients.
Topics: Acidosis; Adult; Anesthetics, Intravenous; Child; Child, Preschool; Contraindications; Humans; Inten | 2002 |
Continuous propofol infusion in 142 critically ill children.
Topics: Acidosis; Adolescent; Analgesics; Cardiovascular Agents; Child; Child, Preschool; Comorbidity; Criti | 2002 |
Propofol syndrome in children.
Topics: Acidosis; Age Factors; Anesthetics, Intravenous; Child; Conscious Sedation; Critical Illness; Hepato | 2003 |
Sedation in pediatric patients.
Topics: Acidosis; Anesthetics, Intravenous; Bradycardia; Child; Conscious Sedation; Drug Monitoring; Humans; | 2003 |
Circulating awareness of adverse effects of propofol.
Topics: Acidosis; Anesthetics, Intravenous; Animals; Animals, Newborn; Blood Gas Analysis; Fatal Outcome; He | 2003 |
Death after re-exposure to propofol in a 3-year-old child: a case report.
Topics: Acidosis; Child, Preschool; Drug Overdose; Fatal Outcome; Female; Humans; Hypnotics and Sedatives; P | 2004 |
A case of propofol toxicity: further evidence for a causal mechanism.
Topics: Acidosis; Acute Kidney Injury; Arrhythmias, Cardiac; Cleft Lip; Conscious Sedation; Humans; Hypnotic | 2004 |
Two reports of propofol anesthesia associated with metabolic acidosis in adults.
Topics: Acidosis; Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Female; Humans; Male; Middle Age | 2004 |
Metabolic acidosis associated with propofol in the absence of other causative factors.
Topics: Acidosis; Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Atrial Fibrillation; Blood Gas A | 2004 |
Fatal propofol infusion syndrome in association with ketogenic diet.
Topics: Acidosis; Anticonvulsants; Child; Diet Therapy; Fatal Outcome; Humans; Infusions, Parenteral; Male; | 2004 |
Propofol infusion syndrome: an unusual cause of renal failure.
Topics: Acidosis; Acute Kidney Injury; Adolescent; Adult; Craniocerebral Trauma; Female; Humans; Infusions, | 2004 |
Metabolic acidosis due to propofol infusion.
Topics: Acidosis; Anesthetics, Intravenous; Humans; Propofol | 2005 |
Rare but dangerous adverse effects of propofol and thiopental in intensive care.
Topics: Acidosis; Adult; Anesthetics, Intravenous; Coma; Conscious Sedation; Critical Care; Fatal Outcome; F | 2005 |
The syndrome of irreversible acidosis after prolonged propofol infusion.
Topics: Acidosis; Adult; Anesthetics, Intravenous; Fatal Outcome; Female; Humans; Infusions, Intravenous; Ma | 2005 |
A lethal complication of propofol.
Topics: Acidosis; Acute Kidney Injury; Adult; Anesthetics, Intravenous; Creatine Kinase; Dose-Response Relat | 2006 |
Toward a prediction of sudden death in propofol-related infusion syndrome.
Topics: Acidosis; Acute Kidney Injury; Death, Sudden, Cardiac; Electrocardiography; Humans; Hypnotics and Se | 2006 |
Electrocardiographic changes predicting sudden death in propofol-related infusion syndrome.
Topics: Acidosis; Acute Kidney Injury; Adolescent; Death, Sudden, Cardiac; Electrocardiography; Humans; Hypn | 2006 |
Propofol infusion syndrome during anaesthesia for scoliosis surgery in an adolescent with neonatal progeroid syndrome.
Topics: Acidosis; Adolescent; Anesthetics, Intravenous; Arrhythmias, Cardiac; Female; Humans; Progeria; Prop | 2006 |
Influence of external and intracellular pH on propofol-induced responses in rat locus coeruleus neurons.
Topics: Acidosis; Animals; Hydrogen-Ion Concentration; In Vitro Techniques; Locus Coeruleus; Male; Pentobarb | 2006 |
Propofol infusion syndrome--a fatal case at a low infusion rate.
Topics: Acidosis; Acute Kidney Injury; Adult; Anesthetics, Intravenous; Bradycardia; Dose-Response Relations | 2006 |
[Propofol infusion syndrome].
Topics: Acidosis; Acute Kidney Injury; Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Arrhythmias, | 2006 |
Short-term low-dose propofol anaesthesia associated with severe metabolic acidosis.
Topics: Acidosis; Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Bicarbonates; Blood Pressure; Ca | 2006 |
Propofol infusion syndrome in a patient with sepsis.
Topics: Abdominal Abscess; Acidosis; Adult; Anesthetics, Intravenous; Drainage; Heart Failure; Humans; Hyper | 2006 |
The 'propofol infusion syndrome': myth or menace?
Topics: Acidosis; Anesthesia; Anesthetics, Intravenous; Critical Care; Diagnosis, Differential; Humans; Hypo | 2006 |
Anesthetic management in a child with deletion 9p syndrome.
Topics: Abnormalities, Multiple; Acidosis; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; At | 2007 |
Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injury.
Topics: Acidosis; Acute Kidney Injury; Adolescent; Anesthetics, Intravenous; Brain Injuries; Fatal Outcome; | 2007 |
Early propofol infusion syndrome following cerebral angiographic embolization for giant aneurysm repair. Case report.
Topics: Acidosis; Anesthetics, Intravenous; Aneurysm; Balloon Occlusion; Cardiac Output, Low; Carotid Artery | 2007 |
Propofol-associated fatal myocardial failure and rhabdomyolysis in an adult with status epilepticus.
Topics: Acidosis; Adult; Age Factors; Anticonvulsants; Cardiac Output, Low; Cardiomyopathies; Fatal Outcome; | 2007 |
Pediatric emergency medicine: legal briefs.
Topics: Acidosis; Administration, Cutaneous; Adult; Asphyxia; Brain Damage, Chronic; Burns, Chemical; Child; | 2007 |
Incidence of propofol infusion syndrome during noninvasive radiofrequency ablation for atrial flutter or fibrillation.
Topics: Acidosis; Anesthetics, Intravenous; Atrial Fibrillation; Atrial Flutter; Catheter Ablation; Dose-Res | 2007 |
[Effects of intravenous anesthetics on acidosis induced apoptosis in primary brain cell culture].
Topics: Acidosis; Anesthetics, Intravenous; Animals; Apoptosis; Brain; Calcium; Cells, Cultured; Female; Hum | 2007 |
Propofol infusion and lactic acidosis.
Topics: Acidosis; Anesthetics, Intravenous; Atrial Fibrillation; Humans; Incidence; Infusions, Intravenous; | 2008 |
Role of propofol in paediatric anaesthetic practice.
Topics: Acidosis; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, | 1995 |
Fatal metabolic acidosis in a pediatric patient receiving an infusion of propofol in the intensive care unit: is there a relationship?
Topics: Acidosis; Child; Conscious Sedation; Fatal Outcome; Female; Heart Arrest; Humans; Infusions, Intrave | 1995 |
Propofol bashing: the time to stop is now!
Topics: Acidosis; Anesthetics, Intravenous; Child; Critical Care; Humans; Propofol | 1996 |
A comparison of propofol and other sedative use in paediatric intensive care in the United Kingdom.
Topics: Acidosis; Adolescent; Child; Child, Preschool; Female; Humans; Hypnotics and Sedatives; Infant; Infu | 1997 |
Fatal outcome after propofol sedation in children.
Topics: Acidosis; Arrhythmias, Cardiac; Cardiac Output, Low; Cause of Death; Child; Creatine Kinase; Dantrol | 1997 |
Propofol and malignant hyperthermia susceptibility.
Topics: Acidosis; Adolescent; Adult; Aged; Anesthetics, Intravenous; Arrhythmias, Cardiac; Cause of Death; C | 1997 |
Anaesthesiological indications and contraindications of minimally invasive surgery.
Topics: Acid-Base Equilibrium; Acidosis; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenou | 1997 |
Disposition of propofol between red blood cells, plasma, brain and cerebrospinal fluid in rabbits.
Topics: Acidosis; Analysis of Variance; Anesthesia Recovery Period; Anesthetics, Intravenous; Animals; Brain | 2000 |
Rare events often happen infrequently: propofol complications revisited.
Topics: Acidosis; Anesthetics, Intravenous; Bradycardia; Child; Humans; Propofol; Rhabdomyolysis; Shock | 2000 |
Death related to propofol use in an adult patient.
Topics: Acidosis; Adolescent; Arrhythmias, Cardiac; Fatal Outcome; Heart Failure; Humans; Male; Propofol; Re | 2000 |
Metabolic acidosis associated with a new formulation of propofol.
Topics: Acidosis; Adult; Arteriovenous Malformations; Chemistry, Pharmaceutical; Fatal Outcome; Female; Huma | 2001 |
Impaired fatty acid oxidation in propofol infusion syndrome.
Topics: Acidosis; Carnitine; Critical Care; Electron Transport; Fatty Acids; Hemofiltration; Humans; Hypnoti | 2001 |
Propofol use in head-injury patients.
Topics: Acidosis; Adolescent; Adult; Anesthetics, Intravenous; Animals; Cardiac Output; Craniocerebral Traum | 2001 |
Metabolic acidosis, rhabdomyolysis, and cardiovascular collapse after prolonged propofol infusion.
Topics: Acidosis; Adolescent; Electrocardiography; Fatal Outcome; Female; Head Injuries, Closed; Heart Disea | 2001 |
Propofol-infusion syndrome.
Topics: Acidosis; Adult; Craniocerebral Trauma; Fatal Outcome; Humans; Hypnotics and Sedatives; Propofol | 2001 |
Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports.
Topics: Acidosis; Acute Disease; Cause of Death; Child; Child, Preschool; Critical Care; Female; Heart Failu | 1992 |
Propofol infusion in children.
Topics: Acidosis; Critical Care; Female; Hemofiltration; Humans; Infant; Propofol | 1992 |