propofol has been researched along with Liver Dysfunction in 28 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propofol acts through the nuclear factor, erythroid-like 2, and heme oxygenase 1 pathway to protect the mice liver against ischemia/reperfusion injury and hepatocytes against hypoxia/reoxygenation injury." | 8.31 | Propofol Pretreatment Inhibits Liver Damage in Mice with Hepatic Ischemia/Reperfusion Injury and Protects Human Hepatocyte in Hypoxia/Reoxygenation. ( Chen, H; Li, J; Wang, R; Wang, W; Yang, X; Yang, Y, 2023) |
| "Taken together, the present study showed that propofol can protect against sepsis-induced liver dysfunction through suppressing hepatic oxidative stress, lipid peroxidation, inflammation, and drug biotransformation and interactions in the liver." | 7.88 | Sepsis-induced liver dysfunction was ameliorated by propofol via suppressing hepatic lipid peroxidation, inflammation, and drug interactions. ( Chen, JT; Chen, RM; Lee, YW; Lin, YW; Tsai, HC; Wu, GJ, 2018) |
| "In this study, propofol requirements administered by target-controlled infusion to maintain similar depths of hypnosis were shown to depend on the severity of chronic virus-related liver dysfunction." | 7.79 | The influence of the severity of chronic virus-related liver disease on propofol requirements during propofol-remifentanil anesthesia. ( Chen, QL; Huang, SQ; Wu, J; Zheng, SS, 2013) |
| "To observe the effect of resveratrol and propofol, used either alone or in combination, on hepatocyte apoptosis in rats with hepatic ischemia-reperfusion injury (HIRI)." | 7.79 | [Protective effect of propofol and resveratrol pretreatment against hepatocyte apoptosis in rats with hepatic ischemia-reperfusion injury]. ( Liu, L; Liu, T; Shen, X; Wang, R; Zhao, G, 2013) |
| "To describe outcome of treatment with propofol and phenobarbital for status epilepticus (SE) after portosystemic shunt (PSS) attenuation." | 7.76 | Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treated with propofol and phenobarbital. ( Claeys, S; Daminet, S; de Rooster, H; Gommeren, K; Hamaide, A, 2010) |
| "A case is presented of the use of a propofol infusion for anaesthesia in a patient with known variegate porphyria." | 7.67 | Is propofol a safe agent in porphyria? ( Hodkinson, BP; Weir, PM, 1988) |
| "Propofol was recently shown to be efficient in the treatment of pruritus secondary to spinal morphine administration." | 6.67 | [Pruritus associated with liver disease: propofol, a new therapeutic approach?]. ( Borgeat, A; Mentha, G; Savioz, D; Wilder-Smith, OH, 1994) |
| "Propofol acts through the nuclear factor, erythroid-like 2, and heme oxygenase 1 pathway to protect the mice liver against ischemia/reperfusion injury and hepatocytes against hypoxia/reoxygenation injury." | 4.31 | Propofol Pretreatment Inhibits Liver Damage in Mice with Hepatic Ischemia/Reperfusion Injury and Protects Human Hepatocyte in Hypoxia/Reoxygenation. ( Chen, H; Li, J; Wang, R; Wang, W; Yang, X; Yang, Y, 2023) |
| "After approval by the institutional animal care and use committee, 36 Japanese White rabbits underwent partial hepatic ischemia for 90 min either under sevoflurane or propofol anesthesia." | 3.88 | Interaction between anesthetic conditioning and ischemic preconditioning on metabolic function after hepatic ischemia-reperfusion in rabbits. ( Kosugi, S; Kotake, Y; Morisaki, H; Nagata, H; Suzuki, T; Yamada, T, 2018) |
| "Taken together, the present study showed that propofol can protect against sepsis-induced liver dysfunction through suppressing hepatic oxidative stress, lipid peroxidation, inflammation, and drug biotransformation and interactions in the liver." | 3.88 | Sepsis-induced liver dysfunction was ameliorated by propofol via suppressing hepatic lipid peroxidation, inflammation, and drug interactions. ( Chen, JT; Chen, RM; Lee, YW; Lin, YW; Tsai, HC; Wu, GJ, 2018) |
| "In this study, propofol requirements administered by target-controlled infusion to maintain similar depths of hypnosis were shown to depend on the severity of chronic virus-related liver dysfunction." | 3.79 | The influence of the severity of chronic virus-related liver disease on propofol requirements during propofol-remifentanil anesthesia. ( Chen, QL; Huang, SQ; Wu, J; Zheng, SS, 2013) |
| "To observe the effect of resveratrol and propofol, used either alone or in combination, on hepatocyte apoptosis in rats with hepatic ischemia-reperfusion injury (HIRI)." | 3.79 | [Protective effect of propofol and resveratrol pretreatment against hepatocyte apoptosis in rats with hepatic ischemia-reperfusion injury]. ( Liu, L; Liu, T; Shen, X; Wang, R; Zhao, G, 2013) |
| "To describe outcome of treatment with propofol and phenobarbital for status epilepticus (SE) after portosystemic shunt (PSS) attenuation." | 3.76 | Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treated with propofol and phenobarbital. ( Claeys, S; Daminet, S; de Rooster, H; Gommeren, K; Hamaide, A, 2010) |
| "A case is presented of the use of a propofol infusion for anaesthesia in a patient with known variegate porphyria." | 3.67 | Is propofol a safe agent in porphyria? ( Hodkinson, BP; Weir, PM, 1988) |
| "Propofol was recently shown to be efficient in the treatment of pruritus secondary to spinal morphine administration." | 2.67 | [Pruritus associated with liver disease: propofol, a new therapeutic approach?]. ( Borgeat, A; Mentha, G; Savioz, D; Wilder-Smith, OH, 1994) |
| " On the basis of pharmacokinetic-pharmacodynamic modelling, a mean blood-brain equilibration half-life of only 2." | 2.38 | Pharmacokinetic implications for the clinical use of propofol. ( Gepts, E; Kanto, J, 1989) |
| " Thus, to scientifically design the dose regimen for clinical trials in specific populations, a HSK3486 physiologically based pharmacokinetic model was developed in 2019 to support model-informed drug development (MIDD)." | 1.91 | Model-informed drug development: The mechanistic HSK3486 physiologically based pharmacokinetic model informing dose decisions in clinical trials of specific populations. ( Li, H; Liu, D; Liu, H; Wang, X; Yao, X; Yu, Z; Zhang, M, 2023) |
| " There was no significant association between the use of propofol or the dosage of propofol and any risk factor, need for blood products, number of hours in the ICU, or survival." | 1.35 | Use of propofol for anesthesia in cats with primary hepatic lipidosis: 44 cases (1995-2004). ( Asakawa, M; Erb, HN; Posner, LP, 2008) |
| "Propofol has been reported to cause discolouration of urine and hair." | 1.29 | Long-term sedation with propofol and green discolouration of the liver. ( Bach, A; Böhrer, H; Böttiger, BW; Motsch, J; Schmidt, H, 1994) |
| " Propofol dosage must be titrated to each patient's needs." | 1.29 | [Diprivan and liver]. ( Servin, F, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (14.29) | 18.7374 |
| 1990's | 4 (14.29) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 11 (39.29) | 24.3611 |
| 2020's | 4 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, M | 1 |
| Yu, Z | 1 |
| Liu, H | 1 |
| Wang, X | 1 |
| Li, H | 1 |
| Yao, X | 1 |
| Liu, D | 1 |
| Li, J | 1 |
| Wang, R | 2 |
| Chen, H | 1 |
| Yang, Y | 1 |
| Yang, X | 1 |
| Wang, W | 1 |
| Bakhtawar, J | 1 |
| Siraj, S | 1 |
| Sulaiman, H | 1 |
| Fung, BM | 1 |
| Leon, DJ | 1 |
| Beck, LN | 1 |
| Tabibian, JH | 1 |
| Wei, L | 1 |
| Chen, WY | 1 |
| Hu, T | 1 |
| Tang, YX | 1 |
| Pan, BB | 1 |
| Jin, M | 1 |
| Kong, GY | 1 |
| Yamada, T | 1 |
| Nagata, H | 1 |
| Kosugi, S | 1 |
| Suzuki, T | 1 |
| Morisaki, H | 1 |
| Kotake, Y | 1 |
| Wu, GJ | 1 |
| Lin, YW | 1 |
| Tsai, HC | 1 |
| Lee, YW | 1 |
| Chen, JT | 1 |
| Chen, RM | 1 |
| Nguyen, TM | 1 |
| Fleyfel, M | 1 |
| Boleslawski, E | 1 |
| M'Ba, L | 1 |
| Geniez, M | 1 |
| Ethgen, S | 1 |
| Béhal, H | 1 |
| Lebuffe, G | 1 |
| Dabir, S | 1 |
| Mohammad-Taheri, Z | 1 |
| Parsa, T | 1 |
| Abbasi-Nazari, M | 1 |
| Radpay, B | 1 |
| Radmand, G | 1 |
| Ge, M | 1 |
| Yao, W | 1 |
| Wang, Y | 1 |
| Yuan, D | 1 |
| Chi, X | 1 |
| Luo, G | 1 |
| Hei, Z | 1 |
| Posner, LP | 1 |
| Asakawa, M | 1 |
| Erb, HN | 1 |
| Thomson, H | 1 |
| Ali, A | 1 |
| Harper, NJ | 1 |
| Gommeren, K | 1 |
| Claeys, S | 1 |
| de Rooster, H | 1 |
| Hamaide, A | 1 |
| Daminet, S | 1 |
| Bamji, N | 1 |
| Cohen, LB | 1 |
| Slankamenac, K | 1 |
| Breitenstein, S | 1 |
| Beck-Schimmer, B | 1 |
| Graf, R | 1 |
| Puhan, MA | 1 |
| Clavien, PA | 1 |
| Wu, J | 1 |
| Huang, SQ | 1 |
| Chen, QL | 1 |
| Zheng, SS | 1 |
| Shen, X | 1 |
| Zhao, G | 1 |
| Liu, T | 1 |
| Liu, L | 1 |
| Snyman, T | 1 |
| Stewart, MJ | 1 |
| Grove, A | 1 |
| Steenkamp, V | 1 |
| Li Volti, G | 1 |
| Galvano, F | 1 |
| Scacco, A | 1 |
| Vanella, L | 1 |
| Murabito, P | 1 |
| Gullo, A | 1 |
| Biondi, A | 1 |
| Gazzolo, D | 1 |
| Vadalà, S | 1 |
| Motsch, J | 1 |
| Schmidt, H | 1 |
| Bach, A | 1 |
| Böttiger, BW | 1 |
| Böhrer, H | 1 |
| Servin, F | 1 |
| Borgeat, A | 1 |
| Mentha, G | 1 |
| Savioz, D | 1 |
| Wilder-Smith, OH | 1 |
| Muehlenberg, K | 1 |
| Weinerth, J | 1 |
| Wiedmann, KH | 1 |
| Meissner, PN | 1 |
| Harrison, GG | 1 |
| Hift, RJ | 1 |
| Blanloeil, Y | 1 |
| Deybach, JC | 1 |
| Kanto, J | 1 |
| Gepts, E | 1 |
| McLouglin, C | 1 |
| Weir, PM | 1 |
| Hodkinson, BP | 1 |
3 reviews available for propofol and Liver Dysfunction
| Article | Year |
|---|---|
Pre-procedural Preparation and Sedation for Gastrointestinal Endoscopy in Patients with Advanced Liver Disease.
Topics: Conscious Sedation; Endoscopy, Gastrointestinal; Fentanyl; Humans; Hypnotics and Sedatives; Liver Di | 2022 |
Endoscopic sedation of patients with chronic liver disease.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Benzodiazepines; Chronic Disease; Conscious Sedation; | 2010 |
Pharmacokinetic implications for the clinical use of propofol.
Topics: Adult; Aged; Aging; Anesthetics; Blood Proteins; Child; Child, Preschool; Dose-Response Relationship | 1989 |
2 trials available for propofol and Liver Dysfunction
| Article | Year |
|---|---|
[Pruritus associated with liver disease: propofol, a new therapeutic approach?].
Topics: Adult; Aged; Double-Blind Method; Fat Emulsions, Intravenous; Female; Humans; Liver Diseases; Male; | 1994 |
Propofol as an i.v. anaesthetic induction agent in variegate porphyria.
Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Humans; Liver Diseases; Middle Aged; Porphyrias; P | 1991 |
23 other studies available for propofol and Liver Dysfunction
| Article | Year |
|---|---|
Model-informed drug development: The mechanistic HSK3486 physiologically based pharmacokinetic model informing dose decisions in clinical trials of specific populations.
Topics: Adult; Aged; Child; Drug Development; Humans; Infant, Newborn; Liver Diseases; Models, Biological; P | 2023 |
Propofol Pretreatment Inhibits Liver Damage in Mice with Hepatic Ischemia/Reperfusion Injury and Protects Human Hepatocyte in Hypoxia/Reoxygenation.
Topics: Animals; Aspartate Aminotransferases; Heme Oxygenase-1; Hepatocytes; Humans; Hypoxia; Ischemia; Lact | 2023 |
Total Intravenous Anaesthesia vs. Inhalational Agents in a Patient with Autoimmune Liver Disease.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2023 |
Effect and mechanism of propofol in hepatic ischemia/reperfusion injury of rat.
Topics: Animals; Apoptosis; Hepatocytes; In Situ Nick-End Labeling; Liver; Liver Diseases; Male; Phosphatidy | 2017 |
Interaction between anesthetic conditioning and ischemic preconditioning on metabolic function after hepatic ischemia-reperfusion in rabbits.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Disease Models, Animal; Hemodynamics; Ischemic Precond | 2018 |
Sepsis-induced liver dysfunction was ameliorated by propofol via suppressing hepatic lipid peroxidation, inflammation, and drug interactions.
Topics: Animals; Drug Interactions; Inflammation; Interleukin-1beta; Interleukin-4; Lipid Peroxidation; Live | 2018 |
Effect of pharmacological preconditioning with sevoflurane during hepatectomy with intermittent portal triad clamping.
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Constriction; Female; Hepatectomy; Humans; | 2019 |
Effects of propofol versus isoflurane on liver function after open thoracotomy.
Topics: Adolescent; Adult; Alanine Transaminase; Alkaline Phosphatase; Anesthesia, Intravenous; Anesthetics, | 2015 |
Propofol alleviates liver oxidative stress via activating Nrf2 pathway.
Topics: Anesthetics, Intravenous; Animals; Drug Evaluation, Preclinical; Intracellular Signaling Peptides an | 2015 |
Use of propofol for anesthesia in cats with primary hepatic lipidosis: 44 cases (1995-2004).
Topics: Anesthetics, Intravenous; Animals; Cat Diseases; Cats; Female; Intubation, Gastrointestinal; Lipidos | 2008 |
Spurious propofol-induced coagulopathy in a patient with hepatic rupture.
Topics: Adult; Blood Coagulation Disorders; Female; Humans; Hypnotics and Sedatives; Liver Diseases; Obstetr | 2008 |
Outcome from status epilepticus after portosystemic shunt attenuation in 3 dogs treated with propofol and phenobarbital.
Topics: Animals; Anticonvulsants; Dog Diseases; Dogs; Female; Liver Diseases; Male; Phenobarbital; Portal Sy | 2010 |
Does pharmacological conditioning with the volatile anaesthetic sevoflurane offer protection in liver surgery?
Topics: Administration, Inhalation; Adult; Aged; Alanine Transaminase; Anesthetics, Inhalation; Anesthetics, | 2012 |
The influence of the severity of chronic virus-related liver disease on propofol requirements during propofol-remifentanil anesthesia.
Topics: Adult; Anesthesia; Anesthetics, Intravenous; Chronic Disease; Electroencephalography; Hepatitis B, C | 2013 |
[Protective effect of propofol and resveratrol pretreatment against hepatocyte apoptosis in rats with hepatic ischemia-reperfusion injury].
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Hepatocytes; Ischemic Preconditioning; Li | 2013 |
Adulteration of South African traditional herbal remedies.
Topics: Acidosis, Lactic; Adult; Chemical and Drug Induced Liver Injury; Child, Preschool; Chromatography, H | 2005 |
Anesthetics and natural heme oxygenase-1 inducers: waiting for carbon monoxide?
Topics: Anesthetics; Animals; Anthocyanins; Antioxidants; Carbon Monoxide; Curcumin; Cytoprotection; Disease | 2008 |
Long-term sedation with propofol and green discolouration of the liver.
Topics: Chemical and Drug Induced Liver Injury; Conscious Sedation; Humans; Laparotomy; Liver; Liver Disease | 1994 |
[Diprivan and liver].
Topics: Humans; Liver; Liver Diseases; Liver Function Tests; Metabolic Clearance Rate; Propofol | 1994 |
[Short-term anesthesia to stop persistent hiccups].
Topics: Adult; Anesthesia; Anesthetics, Intravenous; Hiccup; Humans; Liver Diseases; Male; Neuromuscular Dep | 2001 |
[Propofol (Diprivan) and hepatic porphyria].
Topics: Animals; Chick Embryo; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Liver Diseases; Po | 1989 |
Use of propofol in a patient with porphyria.
Topics: Anesthesia, General; Anesthetics; Female; Humans; Liver Diseases; Middle Aged; Phenols; Porphyrias; | 1989 |
Is propofol a safe agent in porphyria?
Topics: Adult; Anesthesia, Intravenous; Anesthetics; Forearm Injuries; Humans; Liver Diseases; Male; Phenols | 1988 |