propofol has been researched along with Learning Disabilities in 11 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Learning Disabilities: Conditions characterized by a significant discrepancy between an individual's perceived level of intellect and their ability to acquire new language and other cognitive skills. These may result from organic or psychological conditions. Relatively common subtypes include DYSLEXIA, DYSCALCULIA, and DYSGRAPHIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is an ongoing debate as to whether propofol exhibits pro- or anticonvulsant effects, and whether it should be used in patients with epilepsy." | 7.73 | Effect of propofol on seizure-like phenomena and electroencephalographic activity in children with epilepsy vs children with learning difficulties. ( Gortner, L; Gottschling, S; Grundmann, U; Kegel, B; Mencke, T; Meyer, S; Shamdeen, MG, 2006) |
| "3 mg/kg ketamine and then underwent ECT under propofol anesthesia, and a control group, which received isovolumetric placebo (normal saline) and then underwent ECT under propofol anesthesia." | 5.24 | Effect of Low Dose of Ketamine on Learning Memory Function in Patients Undergoing Electroconvulsive Therapy-A Randomized, Double-Blind, Controlled Clinical Study. ( Chen, J; Chen, Q; Hao, X; Li, X; Luo, Q; Meng, H; Min, S; Peng, L, 2017) |
| "There is an ongoing debate as to whether propofol exhibits pro- or anticonvulsant effects, and whether it should be used in patients with epilepsy." | 3.73 | Effect of propofol on seizure-like phenomena and electroencephalographic activity in children with epilepsy vs children with learning difficulties. ( Gortner, L; Gottschling, S; Grundmann, U; Kegel, B; Mencke, T; Meyer, S; Shamdeen, MG, 2006) |
| " Intralipid (10%, 10 mL/kg) for vehicle control and different dosage of propofol for three treatment groups (50, 100 and 200 mg/kg) were administered intraperitoneally." | 1.48 | PKA-CREB-BDNF signaling pathway mediates propofol-induced long-term learning and memory impairment in hippocampus of rats. ( Chen, J; Jiang, Y; Li, L; Pan, S; Qin, Y; Wei, Y; Xie, Y; Zhong, Y, 2018) |
| "The isoflurane anaesthesia treatment increased the escape latency contrast to propofol anaesthesia group." | 1.38 | Changes of learning and memory in aged rats after isoflurane inhalational anaesthesia correlated with hippocampal acetylcholine level. ( Feng, C; Jia, X; Wang, H; Wang, Y; Wu, A; Xu, Z; Yue, Y, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 9 (81.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, L | 1 |
| Wang, S | 1 |
| Feng, Y | 1 |
| Zhao, W | 2 |
| Zuo, W | 1 |
| Zhong, L | 1 |
| Lin, J | 1 |
| Luo, F | 1 |
| Zhong, Y | 1 |
| Chen, J | 3 |
| Li, L | 1 |
| Qin, Y | 1 |
| Wei, Y | 1 |
| Pan, S | 1 |
| Jiang, Y | 1 |
| Xie, Y | 1 |
| Yang, B | 1 |
| Liang, G | 1 |
| Khojasteh, S | 1 |
| Wu, Z | 1 |
| Yang, W | 1 |
| Joseph, D | 1 |
| Wei, H | 1 |
| Zhu, X | 1 |
| Hao, X | 2 |
| Luo, J | 1 |
| Min, S | 2 |
| Xie, F | 1 |
| Zhang, F | 1 |
| Zhang, J | 1 |
| Tan, H | 1 |
| Jiang, W | 1 |
| Zuo, Z | 1 |
| Liu, G | 1 |
| Liu, C | 2 |
| Zhang, XN | 1 |
| Liu, WF | 1 |
| Chen, Q | 1 |
| Peng, L | 1 |
| Meng, H | 1 |
| Luo, Q | 1 |
| Li, X | 1 |
| Wang, H | 1 |
| Xu, Z | 1 |
| Feng, C | 1 |
| Wang, Y | 1 |
| Jia, X | 1 |
| Wu, A | 1 |
| Yue, Y | 1 |
| Meyer, S | 1 |
| Shamdeen, MG | 1 |
| Kegel, B | 1 |
| Mencke, T | 1 |
| Gottschling, S | 1 |
| Gortner, L | 1 |
| Grundmann, U | 1 |
| Baxter, MG | 1 |
| Murphy, KL | 1 |
| Crosby, G | 1 |
| Culley, DJ | 1 |
1 trial available for propofol and Learning Disabilities
| Article | Year |
|---|---|
Effect of Low Dose of Ketamine on Learning Memory Function in Patients Undergoing Electroconvulsive Therapy-A Randomized, Double-Blind, Controlled Clinical Study.
Topics: Adolescent; Adult; Aged; Anesthesia; Anesthetics, Intravenous; Asian People; Depressive Disorder, Ma | 2017 |
10 other studies available for propofol and Learning Disabilities
| Article | Year |
|---|---|
KIF17 mediates the learning and memory impairment in offspring induced by maternal exposure to propofol during middle pregnancy.
Topics: Animals; Biomarkers; Disease Models, Animal; Female; Hippocampus; Kinesins; Learning Disabilities; M | 2018 |
PKA-CREB-BDNF signaling pathway mediates propofol-induced long-term learning and memory impairment in hippocampus of rats.
Topics: Animals; Animals, Newborn; Apoptosis; Brain-Derived Neurotrophic Factor; CREB-Binding Protein; Cycli | 2018 |
Comparison of neurodegeneration and cognitive impairment in neonatal mice exposed to propofol or isoflurane.
Topics: Administration, Inhalation; Anesthetics; Animals; Animals, Newborn; Apoptosis; Brain Damage, Chronic | 2014 |
Propofol inhibits inflammatory cytokine-mediated glutamate uptake dysfunction to alleviate learning/memory impairment in depressed rats undergoing electroconvulsive shock.
Topics: Analysis of Variance; Animals; Cytokines; Depression; Disease Models, Animal; Food Deprivation; Food | 2015 |
The choice of general anesthetics may not affect neuroinflammation and impairment of learning and memory after surgery in elderly rats.
Topics: Anesthetics, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Buprenorphine; Cal | 2015 |
Comparison of the neuropsychological mechanisms of 2,6-diisopropylphenol and N-methyl-D-aspartate receptor antagonist against electroconvulsive therapy-induced learning and memory impairment in depressed rats.
Topics: Animals; Depressive Disorder; Dizocilpine Maleate; Electroconvulsive Therapy; Excitatory Amino Acid | 2015 |
Propofol can Protect Against the Impairment of Learning-memory Induced by Electroconvulsive Shock via Tau Protein Hyperphosphorylation in Depressed Rats.
Topics: Animals; Depression; Dizocilpine Maleate; Electroshock; Glutamic Acid; Learning Disabilities; Male; | 2015 |
Changes of learning and memory in aged rats after isoflurane inhalational anaesthesia correlated with hippocampal acetylcholine level.
Topics: Acetylcholine; Aging; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Brain Chemi | 2012 |
Effect of propofol on seizure-like phenomena and electroencephalographic activity in children with epilepsy vs children with learning difficulties.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Electroencephalo | 2006 |
Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Behavior, Animal; Denervation; Hippocamp | 2008 |