propofol has been researched along with Lactic Acidosis in 29 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This anesthetic drug may cause a rare condition named propofol infusion syndrome, characterized by unexplained lactic acidosis, lipemia, rhabdomyolysis, cardiovascular collapse and Brugada-like electrocardiographic pattern or Brugada electrocardiographic phenocopy changes following high-dose propofol infusion over prolonged periods of time." | 8.86 | Propofol infusion syndrome and Brugada syndrome electrocardiographic phenocopy. ( Dubner, S; Ferreira, C; Filho, CF; Riera, AR; Schapachnik, E; Uchida, AH, 2010) |
| "Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h." | 8.82 | [Propofol infusion syndrome]. ( Motsch, J; Roggenbach, J, 2004) |
| "To this day, the pathophysiology and risk factors of propofol infusion syndrome (PRIS) remain unknown." | 7.96 | Suspected propofol infusion syndrome during normal targeted propofol concentration. ( Ichikawa, T; Kamata, K; Masui, K; Okuyama, K; Ozaki, M, 2020) |
| "Propofol infusion syndrome (PRIS), a rare complication of propofol sedation, is associated with high mortality." | 7.81 | Therapeutic plasma exchange as treatment for propofol infusion syndrome. ( Levin, PD; Levin, V; Rund, D; Sprung, CL; Weissman, C, 2015) |
| " After exclusion of potential causes for this phenomenon, it was attributed to perioperative intravenous propofol infusion causing propofol infusion syndrome." | 7.75 | Propofol infusion syndrome in adult cardiac surgery. ( Balacumaraswami, L; Ilyas, MI; Palin, C; Ratnatunga, C, 2009) |
| "We describe the case of a 7-year-old boy with osteogenesis imperfecta, who underwent anaesthesia with propofol-fentanyl-nitrous oxide-suxamethonium for orthopaedic surgery of a distal femur fracture." | 7.72 | Lacticacidosis after short-term infusion of propofol for anaesthesia in a child with osteogenesis imperfecta. ( Kill, C; Leonhardt, A; Wulf, H, 2003) |
| "Propofol has been associated with severe adverse reactions in children receiving intensive care." | 6.40 | Lactic acidemia and bradyarrhythmia in a child sedated with propofol. ( Cox, PN; Cray, SH; Robinson, BH, 1998) |
| "This anesthetic drug may cause a rare condition named propofol infusion syndrome, characterized by unexplained lactic acidosis, lipemia, rhabdomyolysis, cardiovascular collapse and Brugada-like electrocardiographic pattern or Brugada electrocardiographic phenocopy changes following high-dose propofol infusion over prolonged periods of time." | 4.86 | Propofol infusion syndrome and Brugada syndrome electrocardiographic phenocopy. ( Dubner, S; Ferreira, C; Filho, CF; Riera, AR; Schapachnik, E; Uchida, AH, 2010) |
| "Propofol infusion syndrome has not only been observed in patients undergoing long-term sedation with propofol, but also during propofol anesthesia lasting 5 h." | 4.82 | [Propofol infusion syndrome]. ( Motsch, J; Roggenbach, J, 2004) |
| "To this day, the pathophysiology and risk factors of propofol infusion syndrome (PRIS) remain unknown." | 3.96 | Suspected propofol infusion syndrome during normal targeted propofol concentration. ( Ichikawa, T; Kamata, K; Masui, K; Okuyama, K; Ozaki, M, 2020) |
| "Propofol infusion syndrome (PRIS), a rare complication of propofol sedation, is associated with high mortality." | 3.81 | Therapeutic plasma exchange as treatment for propofol infusion syndrome. ( Levin, PD; Levin, V; Rund, D; Sprung, CL; Weissman, C, 2015) |
| " After exclusion of potential causes for this phenomenon, it was attributed to perioperative intravenous propofol infusion causing propofol infusion syndrome." | 3.75 | Propofol infusion syndrome in adult cardiac surgery. ( Balacumaraswami, L; Ilyas, MI; Palin, C; Ratnatunga, C, 2009) |
| "Lactic acidosis is considered an early sign of propofol infusion syndrome." | 3.75 | Prolonged propofol anesthesia is not associated with an increase in blood lactate. ( Lam, AM; Lee, LA; Rozet, I; Tontisirin, N; Treggiari, MM; Vavilala, MS, 2009) |
| " He developed a marked lactic acidosis with mild biological signs of renal impairment and rhabdomyolysis but no cardiocirculatory failure." | 3.73 | Propofol infusion syndrome associated with short-term large-dose infusion during surgical anesthesia in an adult. ( Guérit, JM; Hantson, P; Liolios, A; Raftopoulos, C; Scholtes, JL, 2005) |
| "Propofol infusion syndrome, characterised by cardiovascular collapse, metabolic acidosis, hepatomegaly, renal failure and rhabdomyolysis, is a rare and often fatal syndrome seen in critically ill children undergoing long-term propofol sedation." | 3.73 | [Propofol infusion syndrome in children]. ( Hansen, TG, 2005) |
| "We describe the case of a 7-year-old boy with osteogenesis imperfecta, who underwent anaesthesia with propofol-fentanyl-nitrous oxide-suxamethonium for orthopaedic surgery of a distal femur fracture." | 3.72 | Lacticacidosis after short-term infusion of propofol for anaesthesia in a child with osteogenesis imperfecta. ( Kill, C; Leonhardt, A; Wulf, H, 2003) |
| "Propofol has been associated with severe adverse reactions in children receiving intensive care." | 2.40 | Lactic acidemia and bradyarrhythmia in a child sedated with propofol. ( Cox, PN; Cray, SH; Robinson, BH, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (17.24) | 18.2507 |
| 2000's | 18 (62.07) | 29.6817 |
| 2010's | 5 (17.24) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Ichikawa, T | 1 |
| Okuyama, K | 1 |
| Kamata, K | 1 |
| Masui, K | 1 |
| Ozaki, M | 1 |
| Saettele, AK | 1 |
| Sharma, A | 1 |
| Murray, DJ | 1 |
| Mtaweh, H | 1 |
| Bayır, H | 1 |
| Kochanek, PM | 1 |
| Bell, MJ | 1 |
| Levin, PD | 1 |
| Levin, V | 1 |
| Weissman, C | 1 |
| Sprung, CL | 1 |
| Rund, D | 1 |
| Parra R, H | 1 |
| Laquay, N | 1 |
| Pouard, P | 1 |
| Silicani, MA | 1 |
| Vaccaroni, L | 1 |
| Orliaguet, G | 1 |
| Ilyas, MI | 1 |
| Balacumaraswami, L | 1 |
| Palin, C | 1 |
| Ratnatunga, C | 1 |
| Bonhomme, V | 1 |
| Demoitie, J | 1 |
| Schaub, I | 1 |
| Hans, P | 1 |
| Rozet, I | 2 |
| Tontisirin, N | 1 |
| Vavilala, MS | 1 |
| Treggiari, MM | 1 |
| Lee, LA | 1 |
| Lam, AM | 2 |
| Riera, AR | 1 |
| Uchida, AH | 1 |
| Schapachnik, E | 1 |
| Dubner, S | 1 |
| Filho, CF | 1 |
| Ferreira, C | 1 |
| Fernández, AB | 1 |
| Fernández, J | 1 |
| Kill, C | 1 |
| Leonhardt, A | 1 |
| Wulf, H | 1 |
| Koch, M | 1 |
| De Backer, D | 1 |
| Vincent, JL | 1 |
| Salengros, JC | 1 |
| Velghe-Lenelle, CE | 1 |
| Bollens, R | 1 |
| Engelman, E | 1 |
| Barvais, L | 1 |
| Motsch, J | 1 |
| Roggenbach, J | 1 |
| Snyman, T | 1 |
| Stewart, MJ | 1 |
| Grove, A | 1 |
| Steenkamp, V | 1 |
| Haase, R | 1 |
| Sauer, H | 1 |
| Eichler, G | 1 |
| Liolios, A | 1 |
| Guérit, JM | 1 |
| Scholtes, JL | 1 |
| Raftopoulos, C | 1 |
| Hantson, P | 1 |
| Hansen, TG | 1 |
| Corbett, SM | 1 |
| Moore, J | 1 |
| Rebuck, JA | 1 |
| Rogers, FB | 1 |
| Greene, CM | 1 |
| Bordes, J | 1 |
| Meaudre, E | 1 |
| Asencio, Y | 1 |
| Montcriol, A | 1 |
| Kaiser, E | 1 |
| Fudickar, A | 1 |
| Tonner, PH | 1 |
| Mihaljovic, Z | 1 |
| Dellien, C | 1 |
| Weiler, N | 1 |
| Scholz, J | 1 |
| Bein, B | 1 |
| Romero P, C | 1 |
| Morales R, M | 1 |
| Donaire R, L | 1 |
| Llanos V, O | 1 |
| Cornejo R, R | 1 |
| Gálvez A, R | 1 |
| Castro O, J | 1 |
| Marinella, MA | 1 |
| Torres, MD | 1 |
| Fernández-Esplá, A | 1 |
| Baeza, C | 1 |
| Torres, C | 1 |
| Soler, G | 1 |
| Buijs, EJ | 1 |
| van Zuylen, HJ | 1 |
| Susla, GM | 1 |
| Cray, SH | 1 |
| Robinson, BH | 1 |
| Cox, PN | 1 |
4 reviews available for propofol and Lactic Acidosis
| Article | Year |
|---|---|
Propofol infusion syndrome and Brugada syndrome electrocardiographic phenocopy.
Topics: Acidosis, Lactic; Anesthetics, Intravenous; Animals; Brugada Syndrome; Electrocardiography; Heart Co | 2010 |
[Propofol infusion syndrome].
Topics: Acid-Base Imbalance; Acidosis, Lactic; Anesthesia, Intravenous; Anesthetics, Intravenous; Chemistry, | 2004 |
Propofol toxicity in critically ill pediatric patients: show us the proof.
Topics: Acidosis, Lactic; Anesthetics, Intravenous; Bradycardia; Child; Child, Preschool; Conscious Sedation | 1998 |
Lactic acidemia and bradyarrhythmia in a child sedated with propofol.
Topics: Acidosis, Lactic; Bradycardia; Conscious Sedation; Fatty Liver; Humans; Hyperlipidemias; Hypnotics a | 1998 |
1 trial available for propofol and Lactic Acidosis
| Article | Year |
|---|---|
Acid-base status and hemodynamic stability during propofol and sevoflurane-based anesthesia in patients undergoing uncomplicated intracranial surgery.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Gen | 2009 |
24 other studies available for propofol and Lactic Acidosis
| Article | Year |
|---|---|
Suspected propofol infusion syndrome during normal targeted propofol concentration.
Topics: Acidosis; Acidosis, Lactic; Adult; Anesthetics, Intravenous; Child; Humans; Infusions, Intravenous; | 2020 |
Case scenario: Hypotonia in infancy: anesthetic dilemma.
Topics: Acidosis, Lactic; Androstanols; Anesthesia; Anesthetics, Intravenous; Biopsy; Bradycardia; Diagnosis | 2013 |
Effect of a single dose of propofol and lack of dextrose administration in a child with mitochondrial disease: a case report.
Topics: Acidosis, Lactic; Adolescent; Blood Pressure; Electroencephalography; Epilepsy; Female; Glucose; Hum | 2014 |
Therapeutic plasma exchange as treatment for propofol infusion syndrome.
Topics: Accidents, Traffic; Acidosis, Lactic; Acute Kidney Injury; Adolescent; Anticonvulsants; Biomarkers; | 2015 |
[Lactic acidosis and propofol].
Topics: Acidosis, Lactic; Anesthetics, Intravenous; Humans; Hypnotics and Sedatives; Propofol | 2008 |
Early stages of propofol infusion syndrome in paediatric cardiac surgery: two cases in adolescent girls.
Topics: Acidosis, Lactic; Adolescent; Anesthetics, Intravenous; Child; Female; Humans; Hypnotics and Sedativ | 2008 |
Propofol infusion syndrome in adult cardiac surgery.
Topics: Acidosis, Lactic; Aged; Anesthetics, Intravenous; Blood Chemical Analysis; Cardiopulmonary Bypass; C | 2009 |
Prolonged propofol anesthesia is not associated with an increase in blood lactate.
Topics: Acidosis, Lactic; Adult; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Drug Administratio | 2009 |
Reversible lactic acidosis and electrocardiographic changes in a neurosurgical patient during propofol anesthesia.
Topics: Acidosis, Lactic; Anesthetics, Inhalation; Anesthetics, Intravenous; Arrhythmias, Cardiac; Electroca | 2010 |
Lacticacidosis after short-term infusion of propofol for anaesthesia in a child with osteogenesis imperfecta.
Topics: Acidosis, Lactic; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Dose-Response Relationsh | 2003 |
Lactic acidosis: an early marker of propofol infusion syndrome?
Topics: Acidosis, Lactic; Anesthetics, Intravenous; Child, Preschool; Female; Humans; Propofol; Syndrome | 2004 |
Lactic acidosis during propofol-remifentanil anesthesia in an adult.
Topics: Acidosis, Lactic; Adenocarcinoma; Anesthesia, Intravenous; Anesthetics, Intravenous; Echocardiograph | 2004 |
Adulteration of South African traditional herbal remedies.
Topics: Acidosis, Lactic; Adult; Chemical and Drug Induced Liver Injury; Child, Preschool; Chromatography, H | 2005 |
Lactic acidosis following short-term propofol infusion may be an early warning of propofol infusion syndrome.
Topics: Acidosis, Lactic; Anesthetics, Intravenous; Child; Craniosynostoses; Humans; Infusions, Intravenous; | 2005 |
Propofol infusion syndrome associated with short-term large-dose infusion during surgical anesthesia in an adult.
Topics: Acidosis, Lactic; Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Brain Stem Neoplasms; El | 2005 |
[Propofol infusion syndrome in children].
Topics: Acidosis, Lactic; Anesthetics, Intravenous; Animals; Arrhythmias, Cardiac; Child; Hepatomegaly; Huma | 2005 |
Survival of propofol infusion syndrome in a head-injured patient.
Topics: Acidosis, Lactic; Adult; Anesthetics, Intravenous; Brain Injuries; Drug Therapy, Combination; Humans | 2006 |
Propofol infusion syndrome or probable overinterpretation syndrome?
Topics: Acidosis, Lactic; Anesthetics, Intravenous; Cohort Studies; Humans; Infusions, Intravenous; Propofol | 2008 |
[Lactic acidosis associated with propofol during general anaesthesia for neurosurgery].
Topics: Acidosis, Lactic; Aged; Anesthesia, General; Anesthetics, Intravenous; Brain Neoplasms; Glioblastoma | 2008 |
Suggested beginning of propofol infusion syndrome in an adult patient without lactacidosis: a case report.
Topics: Acidosis, Lactic; Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Brain Diseases; Creatine | 2008 |
[Severe lactic acidosis caused by propofol infusion: report of one case].
Topics: Acidosis, Lactic; Adult; Anesthetics, Intravenous; Female; Humans; Hypnotics and Sedatives; Infusion | 2008 |
Lactic acidosis associated with propofol.
Topics: Acidosis, Lactic; Adult; Anti-Asthmatic Agents; Asthma; Bicarbonates; Female; Humans; Hypnotics and | 1996 |
[Anesthesia in a case of mitochondrial myopathy].
Topics: Acidosis, Lactic; Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; A | 1996 |
Metabolic consequences of a sorbitol overdose during neurosurgery.
Topics: Acidosis, Lactic; Adenosine Diphosphate; Adenosine Triphosphate; Anesthesia, General; Anesthetics, G | 1997 |