propofol has been researched along with Injury, Ischemia-Reperfusion in 187 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To explore the effects of propofol post-conditioning (PPC) on hepatic ischaemia/reperfusion injury (HIRI) and the potential mechanisms that might be involved in the interaction of Brahma-related gene1(BRG1) and Nuclear-related factor 2(Nrf2)." | 9.24 | Propofol post-conditioning alleviates hepatic ischaemia reperfusion injury via BRG1-mediated Nrf2/HO-1 transcriptional activation in human and mice. ( Cai, J; Chen, C; Chen, H; Ge, M; Hei, Z; Jin, Y; Yao, W; Yuan, D; Zhu, Q, 2017) |
| "From our results, the positive preconditioning impact of sevoflurane on ischemia-reperfusion injury in patients undergoing free flap surgery is expressed in the early postoperative hours, but it does not persist in the long-term." | 9.22 | Protective effect of sevoflurane preconditioning on ischemia-reperfusion injury in patients undergoing reconstructive plastic surgery with microsurgical flap, a randomized controlled trial. ( Claroni, C; Covotta, M; Forastiere, E; Marcelli, ME; Naccarato, A; Scotto Di Uccio, A; Sofra, M; Torregiani, G, 2016) |
| "To determine the effects of a small-dose ketamine-propofol combination used for sedation during spinal anesthesia on tourniquet-induced ischemia-reperfusion injury." | 9.19 | The effects of a small-dose ketamine-propofol combination on tourniquet-induced ischemia-reperfusion injury during arthroscopic knee surgery. ( Akan, B; Baydar, M; Bayrakci, S; Girgin, G; Gogus, N, 2014) |
| "The aim of this study was to compare the effects of propofol and N-acetyl cysteine (NAC) on tourniquet-induced ischaemia-reperfusion injury by determining malonyldialdehyde, ischaemia-modified albumin, lactate, blood gas and haemodynamic levels in arthroscopic knee surgery." | 9.14 | Comparison of the effect of propofol and N-acetyl cysteine in preventing ischaemia-reperfusion injury. ( Cekic, B; Coskun, I; Eroglu, A; Erturk, E; Geze, S; Karahan, C; Kerimoglu, S; Kosucu, M; Mentese, A; Ulusoy, H, 2009) |
| "The Chinese and English medical databases were searched using a combination of the following search terms: "propofol", "liver cancer", "anesthesia surgery", and "ischemia reperfusion injury" in Chinese or English language, respectively." | 9.12 | A meta-analysis and systematic review of propofol on liver ischemia-reperfusion injury protection during hepatocellular carcinoma anesthesia surgery. ( Chen, C; Feng, C; Qian, D, 2021) |
| "To explore the protective effect and mechanism of ligustrazine (LGT) and propofol (PRO) on peri-operational liver ischemia-reperfusion injury (HIRI)." | 9.12 | [Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury]. ( Hu, Z; Lin, LN; Wang, WT; Wu, JZ; Xie, K, 2006) |
| "To explore the protective effect of propofol on liver during hepatic ischemia/reperfusion injury (HIRI) and its mechanisms in patients undergoing liver surgery." | 9.11 | [Protective effect of propofol on liver during ischemia-reperfusion injury in patients undergoing liver surgery]. ( Hu, ZY; Lin, LN; Wang, WT; Wu, JZ; Xie, KJ, 2004) |
| "Propofol may be a good choice of anaesthetic when an ischaemia-reperfusion injury is anticipated as in orthopaedic surgery requiring a tourniquet, due to its antioxidant properties, but halothane needs further study." | 9.09 | The effects of propofol or halothane on free radical production after tourniquet induced ischaemia-reperfusion injury during knee arthroplasty. ( Aldemir, O; Celebi, H; Cevik, C; Duzgun, E, 2001) |
| " Propofol (PRO) possesses a positive protective effect on liver ischemia reperfusion injury." | 8.31 | Propofol improves ischemia reperfusion-induced liver fibrosis by regulating lncRNA HOXA11-AS. ( Liao, Q; Liao, Y; Liu, J; Luo, F; Luo, J; Mou, Y, 2023) |
| "Propofol acts through the nuclear factor, erythroid-like 2, and heme oxygenase 1 pathway to protect the mice liver against ischemia/reperfusion injury and hepatocytes against hypoxia/reoxygenation injury." | 8.31 | Propofol Pretreatment Inhibits Liver Damage in Mice with Hepatic Ischemia/Reperfusion Injury and Protects Human Hepatocyte in Hypoxia/Reoxygenation. ( Chen, H; Li, J; Wang, R; Wang, W; Yang, X; Yang, Y, 2023) |
| "Evidence reveals that propofol protects cells via suppressing excessive autophagy induced by hypoxia/reoxygenation (H/R)." | 8.12 | Propofol Upregulates MicroRNA-30b to Inhibit Excessive Autophagy and Apoptosis and Attenuates Ischemia/Reperfusion Injury In Vitro and in Patients. ( Cai, S; Cai, W; Chen, X; Li, M; Lu, Y; Lu, Z; Mo, G; Mo, J; Ruan, Z; Shen, J; Tang, J; Yang, Y; Zhang, L, 2022) |
| "To analyze the effect of different doses of propofol on pulmonary function and inflammatory response in patients with lung ischemia reperfusion injury (LIRI) induced by one-lung ventilation (OLV) based on big data analysis." | 8.12 | Effect of Different Doses of Propofol on Pulmonary Function and Inflammatory Response in Patients with Lung Ischemia Reperfusion Injury Induced by One-Lung Ventilation Based on Big Data Analysis. ( Du, B; Gu, T; Gu, Y; Liu, X, 2022) |
| "To verify whether propofol alleviates liver ischemia-reperfusion injury (IRI) in mice by regulating Cyp2b10/ Cyp3a25 pathway." | 8.12 | Protection of propofol on liver ischemia reperfusion injury by regulating Cyp2b10/ Cyp3a25 pathway. ( Sun, C; Wu, J; Xu, Y; Yu, C; Zeng, X, 2022) |
| "This study aimed to investigate the effects of propofol on cardiac function and miR-494 expression in rats with hepatic ischemia/reperfusion (I/R) injury." | 8.02 | Effects of propofol on cardiac function and miR-494 expression in rats with hepatic ischemia/reperfusion injury. ( Lv, J; Ou, W; Sun, C; Yu, C; Zou, X, 2021) |
| "Propofol (PPF) plays a protective role in ischemia-reperfusion (I/R) in multiple organs, including renal ischemia-reperfusion injury (RIRI)." | 8.02 | Propofol attenuates renal ischemia/reperfusion injury by regulating the MALAT1/miR-126-5p axis. ( Hu, Y; Li, A; Li, X; Zhang, Z, 2021) |
| "Propofol (PPF) is reported to play a protective role in ischemia/reperfusion (I/R) injury, including cerebral ischemia-reperfusion injury (CIRI)." | 8.02 | Propofol Downregulates lncRNA MALAT1 to Alleviate Cerebral Ischemia-Reperfusion Injury. ( Chen, J; Cheng, S; Hu, Y; Ye, C, 2021) |
| "To investigate the effect of propofol on the expression and phosphorylation of the skeletal muscle insulin receptor and its substrates following hepatic ischemia-reperfusion injury (HIRI)." | 7.96 | Effect of propofol on the skeletal muscle insulin receptor in rats with hepatic ischemia-reperfusion injury. ( Chen, C; Chen, Z; Liu, C; Wang, X; Zhang, L, 2020) |
| "The aim of this study was to investigate the effects of propofol on intestinal ischemia-reperfusion injury in rats through the nuclear factor-kappa B (NF-κB) pathway." | 7.96 | Propofol improves intestinal ischemia-reperfusion injury in rats through NF-κB pathway. ( Cui, SM; He, SC; Ma, B; Wu, MB; Zhang, TX; Zhao, K, 2020) |
| "Propofol is widely used in general anesthesia, and it has been reported to protect various organs against ischemia-reperfusion injury (IRI), including liver." | 7.96 | Ischemic Preconditioning Protects Against Hepatic Ischemia-Reperfusion Injury Under Propofol Anesthesia in Rats. ( Choi, JW; Gwak, MS; Hahm, TS; Han, S; Jeon, SY; Kim, D; Kim, GS; Ko, JS; Ryu, S, 2020) |
| "Propofol may help to protect against ischaemic acute kidney injury (AKI); however, research on this topic is sparse." | 7.91 | Effect of sevoflurane-based or propofol-based anaesthesia on the incidence of postoperative acute kidney injury: A retrospective propensity score-matched analysis. ( Han, S; Jheon, S; Ji, E; Kim, J; Kim, K; Oh, TK, 2019) |
| " Propofol (2,6-diisopropylphenol) has been proven to attenuate mitochondrial dysfunction and reperfusion injury." | 7.88 | Propofol Prevents Oxidative Stress by Decreasing the Ischemic Accumulation of Succinate in Focal Cerebral Ischemia-Reperfusion Injury. ( Gao, D; Jin, W; Liu, S; Qi, S; Yu, W, 2018) |
| "This experimental study aims to observe whether the protective effect of propofol against renal ischemia-reperfusion injury (IRI) in the rat interlobar artery occurs through altered expression of the gap junction protein connexin 43 (Cx43)." | 7.88 | The Protective Effect of Propofol Against Ischemia-Reperfusion Injury in the Interlobar Arteries: Reduction of Abnormal Cx43 Expression as a Possible Mechanism. ( Chang, YC; Ji, W; Li, L; Ma, KT; Shan, LY; Shi, WY; Si, JQ; Tan, CY; Wang, Y; Wang, YP; Xue, WJ; Zhang, L, 2018) |
| " The study aimed to estimate the efficacy of estrogen and propofol combination therapy against ERS-induced apoptosis after cerebral ischemia-reperfusion injury and oxygen-glucose deprivation (OGD) injury in the hippocampus in vivo and in vitro." | 7.88 | Estrogen and propofol combination therapy inhibits endoplasmic reticulum stress and remarkably attenuates cerebral ischemia-reperfusion injury and OGD injury in hippocampus. ( Li, Y; Ma, R; Wang, E; Wang, S; Xiong, E; Xu, F; Yin, J; Zhang, G; Zhang, Q, 2018) |
| "Early apoptosis was significantly higher in isoflurane and propofol anesthetized animals subjected to renal ischemia-reperfusion injury when compared to both cyclosporine A treated and sham groups." | 7.85 | Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats. ( Carvalho, LR; Castiglia, YM; Deffune, E; Golim, MA; Lemos, SV; Módolo, NS; Nascimento, PD; Souza, AV; Vianna, IG; Vianna, PT, 2017) |
| "Both propofol and sevoflurane attenuated the extent of hepatic ischemia/reperfusion injury which is evident from the hisopathological studies and alterations in liver enzymes such as AST and LDH by inhibiting Nuclear factor kappa B (NFx03BA;B) activation and subsequent alterations in inflammatory cytokines interleukin-1(IL-1), interleukin-6(IL-6), tumor necrosis factor-alpha (TNF-α) and increased IL10 release." | 7.83 | The Effects of Two Anesthetics, Propofol and Sevoflurane, on Liver Ischemia/Reperfusion Injury. ( Qi, F; Wang, H; Wang, Z; Wu, J; Xu, Z; Yu, J, 2016) |
| "To investigate the effect of propofol on the expression of rabbit ischemia-reperfusion injury-related proteins and the mechanism involved." | 7.81 | The effect of propofol on the expression of rabbit ischemia reperfusion injury-related proteins. ( Dong, M; Dong, R; Fang, L; Li, S; Xu, Z, 2015) |
| "Propofol is a commonly used intravenous anesthetic that has been demonstrated to be neuroprotective against cerebral ischemia-reperfusion (I/R) injury." | 7.81 | Propofol prevents neuronal mtDNA deletion and cerebral damage due to ischemia/reperfusion injury in rats. ( Chang, FF; Dong, H; Liu, Y; Lu, SJ; Qian, H; Song, CY; Wang, YF; Yang, WC; Yue, ZY, 2015) |
| "It has been shown in our previous study that propofol postconditioning enhanced the activity of phosphatidylinositol-3-kinase (PI3K) and prevented the internalization of GluR2 subunit of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thus provided neuroprotection in cerebral ischemia/reperfusion (I/R) injury." | 7.81 | The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats. ( Liu, S; Wang, G; Wang, H; Zhu, A, 2015) |
| "Propofol, an intravenous anesthetic, inhibits neuronal apoptosis induced by ischemic stroke, protects the brain from ischemia/reperfusion injury and improves neuronal function." | 7.81 | Propofol post-conditioning protects the blood brain barrier by decreasing matrix metalloproteinase-9 and aquaporin-4 expression and improves the neurobehavioral outcome in a rat model of focal cerebral ischemia-reperfusion injury. ( Cao, MH; Ji, FT; Liang, JJ; Miao, LP; Wu, Q, 2015) |
| "To investigate the protective effect of propofol against focal cerebral ischemia/reperfusion (I/R) injury in rats and its relation with gap junction." | 7.81 | [Protective effect of propofol against cerebral ischemic/reperfusion injury may involve inhibition of gap junction]. ( Chen, Y; Dong, S; Fan, Z; Li, Y; Liu, H; Tong, X; Yu, L, 2015) |
| "The general anesthetic propofol protects the adult heart against ischemia and reperfusion injury; however, its efficacy has not been investigated in the immature heart." | 7.80 | Propofol protects the immature rabbit heart against ischemia and reperfusion injury: impact on functional recovery and histopathological changes. ( Imura, H; Nitta, T; Shirakawa, M, 2014) |
| "Sixty rats were randomly assigned to four groups: normoglycemia-etomidate, normoglycemia-propofol, hyperglycemia-etomidate, and hyperglycemia-propofol." | 7.79 | Propofol attenuates renal ischemia-reperfusion injury aggravated by hyperglycemia. ( Jun, JH; Kwak, YL; Lim, BJ; Shim, JK; Yoo, KJ; Yoo, YC, 2013) |
| "To study the effect of isoflurane (Iso) or propofol (Prop) anesthesia on renal ischemia/reperfusion injury (IRI) during transient hyperglycemia." | 7.79 | Do propofol and isoflurane protect the kidney against ischemia/reperfusion injury during transient hyperglycemia? ( Carraretto, AR; Carvalho, LR; Castiglia, YM; Deffune, E; Golim, Mde A; Souza, AV; Vianna Filho, PT; Vianna, PT, 2013) |
| "To investigate the protective effects of propofol in brain ischemia/reperfusion injury and the role of heme oxygenase-1 (HO-1) in this process." | 7.79 | Propofol attenuates cerebral ischemia/reperfusion injury partially using heme oxygenase-1. ( Cang, J; Liang, C; Wang, H; Xue, Z, 2013) |
| "To observe the effect of resveratrol and propofol, used either alone or in combination, on hepatocyte apoptosis in rats with hepatic ischemia-reperfusion injury (HIRI)." | 7.79 | [Protective effect of propofol and resveratrol pretreatment against hepatocyte apoptosis in rats with hepatic ischemia-reperfusion injury]. ( Liu, L; Liu, T; Shen, X; Wang, R; Zhao, G, 2013) |
| "This experimental study aimed to investigate the antioxidant effects of propofol anesthesia at induction doses in a rat skeletal muscle ischemia/reperfusion injury model." | 7.78 | Antioxidant effects of propofol on tourniquet-induced ischemia-reperfusion injury: an experimental study. ( Bostan, B; Erkorkmaz, U; Ozkan, F; Ozyurt, H; Senayli, Y, 2012) |
| "Propofol has been demonstrated to improve hepatic perfusion in a rabbit model; however, the effects of propofol on hepatic ischemia/reperfusion injury are unknown." | 7.78 | Propofol attenuates hepatic ischemia/reperfusion injury in an in vivo rabbit model. ( Luo, CZ; McCluskey, SA; Pang, QY; Ye, L; Zhu, T, 2012) |
| "Monitoring of exhaled pentane may be useful for evaluating the severity of hepatic ischemia-reperfusion injury and aid in predicting the outcome; propofol may improve the outcome in this situation." | 7.78 | Breath pentane as a potential biomarker for survival in hepatic ischemia and reperfusion injury--a pilot study. ( Gong, Y; He, Y; Li, E; Li, J; Li, P; Liu, D; Liu, S; Luo, A; Shi, J; Sun, B; Wang, C; Xu, G, 2012) |
| "To investigate the protective effect and mechanisms of Fospropofol disodium on in vivo liver ischemia-reperfusion injury in rats." | 7.77 | [Protective effect of fospropofol disodium on in vivo liver ischemia-reperfusion injury in rats]. ( Liu, Y; Luo, CZ, 2011) |
| "Our aim was to investigate the long-term preventive effect of propofol on testicular ischemia-reperfusion injury in a rat model." | 7.77 | Does propofol prevent testicular ischemia-reperfusion injury due to torsion in the long term? ( Cobanoğlu, U; Gör, A; Karagüzel, E; Kutlu, O; Senel, AC; Taşkara, E; Topbaş, M, 2011) |
| "Propofol is an intravenous anesthetic with neuroprotective effects against cerebral ischemia-reperfusion (I/R) injury." | 7.77 | Propofol improved neurobehavioral outcome of cerebral ischemia-reperfusion rats by regulating Bcl-2 and Bax expression. ( Cui, XG; Lu, SJ; Song, CY; Tao, T; Xi, HJ; Yue, ZY; Zhang, TH, 2011) |
| "Use of sevoflurane compared with propofol attenuated the haemodynamic sequelae of reperfusion injury in our model." | 7.74 | Effects of sevoflurane and propofol on ischaemia-reperfusion injury after thoracic-aortic occlusion in pigs. ( Annecke, T; Bittmann, I; Conzen, PF; Hilberath, JM; Kahr, S; Kemming, GI; Kubitz, JC; Langer, K; Rehm, M, 2007) |
| "We have previously demonstrated, in the isolated rat heart, that propofol attenuates hydrogen peroxide-induced damage and ischaemia-reperfusion injury, and that the beneficial effect of propofol is correlated with reduction of the lipid peroxidation." | 7.74 | Propofol attenuates ischaemia-reperfusion injury in the rat heart in vivo. ( Kobayashi, I; Kokita, N; Namiki, A, 2008) |
| "It is still unclear whether propofol may protect the liver against ischemia/ reperfusion injury (IRI) in vivo." | 7.74 | Effects of propofol on early phase of warm hepatic ischemia/reperfusion injury. ( Choi, JH; Jee, D; Kim, JY; Kim, SK, 2007) |
| "To study the therapeutic effect and its mechanisms of propofol on gastric mucosal injury after hemorrhagic shock with reperfusion in rabbits." | 7.74 | [Effect of propofol on gastric mucosal injury after hemorrhagic shock and reperfusion in rabbits]. ( Li, HY; Lü, YX; Wang, LL; Zhang, LF, 2008) |
| "To investigate the role of oxygen free radicals (OFR) in hepatic ischemia and reperfusion injury (HI/RI) and effect of propofol on them." | 7.73 | [Effect of propofol on anti-oxidation capability in the ischemia/reperfusion injury after hepatic ischemia in rabbits]. ( Li, D; Lin, LN; Wang, W; Wang, WT, 2005) |
| " The aim of the study was to investigate the preventive effects of thiopental and propofol as anesthetics on testicular ischemia-reperfusion injury." | 7.73 | The preventive effects of thiopental and propofol on testicular ischemia-reperfusion injury. ( Ayyildiz, A; Caydere, M; Germiyanoglu, C; Karaguzel, E; Nuhoglu, B; Ogus, E; Surer, H; Yagmurdur, H, 2006) |
| "To investigate the effects of propofol, midazolam and thiopental sodium on outcomes and amino acid accumulation in focal cerebral ischemia-reperfusion in rats." | 7.72 | Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats. ( Chen, L; Gong, Q; Xiao, C, 2003) |
| "We examined the effect of propofol on the main mechanisms involved in ischemia/reperfusion-induced arrhythmias (i." | 7.72 | Propofol decreases reperfusion-induced arrhythmias in a model of "border zone" between normal and ischemic-reperfused guinea pig myocardium. ( Bricard, H; Ducouret, P; Flais, F; Gérard, JL; Hanouz, JL; Rouet, R; Yvon, A, 2003) |
| "To investigate the protective efficacy of propofol against lung injury during hemorrhagic shock and resuscitation among Rhesus macaques." | 7.71 | [Effect of propofol on protecting Rhesus macaques from reperfusion lung injury during hemorrhagic shock and resuscitation]. ( Huang, X; Song, Q; Wang, M; Zhang, H, 2002) |
| " We measured the levels of malondialdehyde as a marker of lipid peroxidation in ischemic tissue, and the results indicate that propofol plays a role in the inhibition of neuronal death induced by brain ischemia." | 7.71 | Neuroprotective effects of propofol following global cerebral ischemia in rats. ( Akdemir, G; Ergün, R; Ergüngör, F; Sen, S; Taşçi, A, 2002) |
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 7.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "We investigated the effects of selective and non-selective endothelin (ET) antagonists on warm ischemia-reperfusion injury of the early phase in the murine liver under propofol anesthesia." | 7.70 | [Effects of endothelin antagonists on isolated perfused murine livers in the early phase of warm ischemia-reperfusion injury under propofol anesthesia]. ( Karasawa, F; Sato, T; Tanaka, K, 1999) |
| "It has been suggested that propofol has the protective effect on cerebral ischemia-reperfusion injury." | 7.70 | Effectiveness of propofol pretreatment on the extent of deranged cerebral mitochondrial oxidative enzyme system after incomplete forebrain ischemia/reperfusion in rats. ( Chung, C; Lee, Y; Oh, YS, 2000) |
| "This study was designed to test the hypothesis that propofol, which possesses antioxidant properties, would produce greater protection than isoflurane in cerebral ischaemia reperfusion injury, at dose levels that produced similar affects on brain electrical activity." | 7.69 | Propofol neuroprotection in a rat model of ischaemia reperfusion injury. ( Jones, JG; Matta, BF; Menon, DK; Tisavipat, N; Young, Y, 1997) |
| "Propofol could further activate the pathway, which reduced intestinal injury, inhibited apoptosis, reversed inflammation and oxidative stress, and improved the 24-hour survival rate in II/R rats in vivo, and attenuated H/R-induced IEC-6 cell injury, oxidative stress, and apoptosis in vitro, as fine as changes in AICAR treatment." | 5.72 | The role of AMPK-Sirt1-autophagy pathway in the intestinal protection process by propofol against regional ischemia/reperfusion injury in rats. ( Chen, Y; Feng, JG; Jia, J; Liu, X; Tan, YF; Wang, MH; Yang, B; Yang, CJ; Zhou, J, 2022) |
| "Propofol could activate YAP through dephosphorylation." | 5.48 | Propofol Protects Hippocampal Neurons from Hypoxia-Reoxygenation Injury by Decreasing Calcineurin-Induced Calcium Overload and Activating YAP Signaling. ( Cai, H; Li, X; Liang, Q; Qu, H; Yao, L, 2018) |
| "Pretreatment with propofol attenuates autogenous orthotropic liver transplantation induces hippocampal injury via JAK2/STAT3 pathway." | 5.46 | Propofol postconditioning attenuates hippocampus ischemia-reperfusion injury via modulating JAK2/STAT3 pathway in rats after autogenous orthotropic liver transplantation. ( Du, H; Gu, X; Jia, L; Li, S; Sheng, M; Wang, F; Wang, G; Weng, Y; Yu, W, 2017) |
| "Propofol has been found to play an important role in hepatic ischemia/reperfusion (I/R) injury with the antioxidant effects." | 5.46 | Propofol protects against hepatic ischemia/reperfusion injury via miR-133a-5p regulating the expression of MAPK6. ( Hao, W; Lei, SQ; Meng, QT; Tie, ME; Xia, ZY; Zhao, ZH, 2017) |
| "Propofol could inhibit mitochondrial fission and mitochondrial apoptotic pathway evoked by OGD/R in rat hippocampal neurons, which may be via depressing calcium-overload." | 5.43 | The Effect of Propofol on Mitochondrial Fission during Oxygen-Glucose Deprivation and Reperfusion Injury in Rat Hippocampal Neurons. ( Guo, Y; Jia, C; Liu, M; Wang, H; Wang, S; Wang, X; Xue, S; Zheng, S, 2016) |
| "Propofol was reported to attenuate endothelial adhesion molecule expression in some situations." | 5.42 | Propofol ameliorates endothelial inflammation induced by hypoxia/reoxygenation in human umbilical vein endothelial cells: Role of phosphatase A2. ( Chen, J; Ding, J; Jiang, H; Kong, L; Miao, C; Sun, Z; Zhu, M, 2015) |
| "Propofol pretreated IR rats had lower Bax/Bcl-2 ratio and less cleaved caspase-3." | 5.42 | Propofol Prevents Renal Ischemia-Reperfusion Injury via Inhibiting the Oxidative Stress Pathways. ( Jia, Y; Lei, L; Li, Y; Yang, B; Zhong, D; Zhou, H, 2015) |
| "Propofol has been shown to attenuate brain injury in experimental ischemia models, but few studies have focused on the direct effect of propofol on mitochondrial dysfunction." | 5.40 | The effects of propofol on mitochondrial dysfunction following focal cerebral ischemia-reperfusion in rats. ( Li, B; Li, J; Li, XT; Qi, SH; Yu, W, 2014) |
| "Pretreatment with propofol in conditions of hepatic I/R inhibits the apoptosis of hepatocytes as evidenced by decreased terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells." | 5.39 | Role of glycogen synthase kinase 3β in protective effect of propofol against hepatic ischemia-reperfusion injury. ( Chen, B; Lv, Y; Ma, H; Qu, P; Shen, X; Tie, R; Xu, GF; Yu, J; Zhang, H; Zhao, G; Zhu, YL, 2013) |
| "Rats underwent 2 h of middle cerebral artery occlusion (MCAO) followed by 22 h of reperfusion were randomly divided into nine groups (n=15 each): sham-operated group, MCAO group, propofol 10, 20 and 35 mg x kg(-1) x h(-1) group (propofol 10, 20, 35 mg x kg(-1) x h(-1) infused at the onset of reperfusion for 30 min), wortmannin group (wortmannin 0." | 5.35 | The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats. ( Wang, GL; Wang, HY; Wang, Y; Yu, YH, 2009) |
| "Groups 1 and 3 (control groups) had no testicular torsion and detorsion." | 5.35 | Propofol reduces nitric oxide-induced apoptosis in testicular ischemia-reperfusion injury by downregulating the expression of inducible nitric oxide synthase. ( Akgul, T; Ayyildiz, A; Germiyanoglu, C; Karaguzel, E; Ustun, H; Yagmurdur, H, 2008) |
| "Propofol has been demonstrated to ameliorate cerebral ischemic injury and attenuate changes in multiple links of molecular reaction included in the paths to apoptosis." | 5.35 | Effect of propofol on pathologic time-course and apoptosis after cerebral ischemia-reperfusion injury. ( Chen, L; Jiang, H; Xue, Z, 2008) |
| "Pretreatment with propofol prevented a further increase in MDA levels and significantly decreased CAT activity following detorsion." | 5.32 | Propofol attenuates reperfusion injury after testicular torsion and detorsion. ( Balbay, MD; Bozoklu, A; Devrim, E; Durak, I; Eroglu, M; Guven, C; Unsal, A, 2004) |
| "We investigated the effects of propofol vs desflurane on ischemia and reperfusion injury (IRI)-induced inflammatory responses, especially in matrix metalloproteinase-9 (MMP-9) downregulation and heme oxygenase-1 (HO-1) upregulation, which may result in different clinical outcomes in liver transplant recipients." | 5.30 | Propofol vs desflurane on the cytokine, matrix metalloproteinase-9, and heme oxygenase-1 response during living donor liver transplantation: A pilot study. ( Chen, TW; Huang, YS; Hung, NK; Lee, MS; Lin, WL; Lu, CH; Wu, ZF, 2019) |
| "Sixty patients undergoing intracranial aneurysm clipping were randomized into a propofol post-conditioning group or a sevoflurane group." | 5.30 | Propofol post-conditioning after temporary clipping reverses oxidative stress in aneurysm surgery. ( Guo, D; Hua, W; Li, Y; Miao, L; Tang, Q; Wang, G; Wang, H; Wang, X, 2019) |
| "Propofol is an anaesthetic that resembles α-tocopherol and it has been suggested that it protects against ischaemia-reperfusion injury in liver transplantation." | 5.30 | Propofol intravenous anaesthesia with desflurane compared with desflurane alone on postoperative liver function after living-donor liver transplantation: A randomised controlled trial. ( Bae, MI; Heo, E; Joo, DJ; Kim, DW; Kim, MS; Lee, JS; Shin, S; Yoo, YC, 2019) |
| "To explore the effects of propofol post-conditioning (PPC) on hepatic ischaemia/reperfusion injury (HIRI) and the potential mechanisms that might be involved in the interaction of Brahma-related gene1(BRG1) and Nuclear-related factor 2(Nrf2)." | 5.24 | Propofol post-conditioning alleviates hepatic ischaemia reperfusion injury via BRG1-mediated Nrf2/HO-1 transcriptional activation in human and mice. ( Cai, J; Chen, C; Chen, H; Ge, M; Hei, Z; Jin, Y; Yao, W; Yuan, D; Zhu, Q, 2017) |
| "From our results, the positive preconditioning impact of sevoflurane on ischemia-reperfusion injury in patients undergoing free flap surgery is expressed in the early postoperative hours, but it does not persist in the long-term." | 5.22 | Protective effect of sevoflurane preconditioning on ischemia-reperfusion injury in patients undergoing reconstructive plastic surgery with microsurgical flap, a randomized controlled trial. ( Claroni, C; Covotta, M; Forastiere, E; Marcelli, ME; Naccarato, A; Scotto Di Uccio, A; Sofra, M; Torregiani, G, 2016) |
| "To determine the effects of a small-dose ketamine-propofol combination used for sedation during spinal anesthesia on tourniquet-induced ischemia-reperfusion injury." | 5.19 | The effects of a small-dose ketamine-propofol combination on tourniquet-induced ischemia-reperfusion injury during arthroscopic knee surgery. ( Akan, B; Baydar, M; Bayrakci, S; Girgin, G; Gogus, N, 2014) |
| "The aim of this study is to compare the effects of sevoflurane and propofol on one lung ventilation (OLV) induced ischemia-reperfusion injury (IRI) by determining the blood gas, ischemia-modified albumin (IMA), and malonyldialdehyde (MDA)." | 5.19 | The comparison of the effects of sevoflurane inhalation anesthesia and intravenous propofol anesthesia on oxidative stress in one lung ventilation. ( Beşir, A; Demirci, Y; Dohman, D; Erturk, E; Kayir, S; Kutanis, D; Mentese, A; Topaloglu, S, 2014) |
| "These data confirm that TIVA with propofol attenuates oxidative stress related to tourniquet-induced ischaemia-reperfusion injury in children." | 5.17 | Tourniquet-induced ischemia-reperfusion injuries during extremity surgery at children's age: impact of anesthetic chemical structure. ( Budic, I; Cvetkovic, T; Jevtovic-Stoimenov, T; Kitic, D; Kocic, G; Pavlovic, D; Simic, D, 2013) |
| "The aim of this study was to compare the effects of propofol and N-acetyl cysteine (NAC) on tourniquet-induced ischaemia-reperfusion injury by determining malonyldialdehyde, ischaemia-modified albumin, lactate, blood gas and haemodynamic levels in arthroscopic knee surgery." | 5.14 | Comparison of the effect of propofol and N-acetyl cysteine in preventing ischaemia-reperfusion injury. ( Cekic, B; Coskun, I; Eroglu, A; Erturk, E; Geze, S; Karahan, C; Kerimoglu, S; Kosucu, M; Mentese, A; Ulusoy, H, 2009) |
| "The Chinese and English medical databases were searched using a combination of the following search terms: "propofol", "liver cancer", "anesthesia surgery", and "ischemia reperfusion injury" in Chinese or English language, respectively." | 5.12 | A meta-analysis and systematic review of propofol on liver ischemia-reperfusion injury protection during hepatocellular carcinoma anesthesia surgery. ( Chen, C; Feng, C; Qian, D, 2021) |
| "To explore the protective effect and mechanism of ligustrazine (LGT) and propofol (PRO) on peri-operational liver ischemia-reperfusion injury (HIRI)." | 5.12 | [Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury]. ( Hu, Z; Lin, LN; Wang, WT; Wu, JZ; Xie, K, 2006) |
| "To explore the protective effect of propofol on liver during hepatic ischemia/reperfusion injury (HIRI) and its mechanisms in patients undergoing liver surgery." | 5.11 | [Protective effect of propofol on liver during ischemia-reperfusion injury in patients undergoing liver surgery]. ( Hu, ZY; Lin, LN; Wang, WT; Wu, JZ; Xie, KJ, 2004) |
| "Propofol may be a good choice of anaesthetic when an ischaemia-reperfusion injury is anticipated as in orthopaedic surgery requiring a tourniquet, due to its antioxidant properties, but halothane needs further study." | 5.09 | The effects of propofol or halothane on free radical production after tourniquet induced ischaemia-reperfusion injury during knee arthroplasty. ( Aldemir, O; Celebi, H; Cevik, C; Duzgun, E, 2001) |
| " Propofol (PRO) possesses a positive protective effect on liver ischemia reperfusion injury." | 4.31 | Propofol improves ischemia reperfusion-induced liver fibrosis by regulating lncRNA HOXA11-AS. ( Liao, Q; Liao, Y; Liu, J; Luo, F; Luo, J; Mou, Y, 2023) |
| "Propofol acts through the nuclear factor, erythroid-like 2, and heme oxygenase 1 pathway to protect the mice liver against ischemia/reperfusion injury and hepatocytes against hypoxia/reoxygenation injury." | 4.31 | Propofol Pretreatment Inhibits Liver Damage in Mice with Hepatic Ischemia/Reperfusion Injury and Protects Human Hepatocyte in Hypoxia/Reoxygenation. ( Chen, H; Li, J; Wang, R; Wang, W; Yang, X; Yang, Y, 2023) |
| "Evidence reveals that propofol protects cells via suppressing excessive autophagy induced by hypoxia/reoxygenation (H/R)." | 4.12 | Propofol Upregulates MicroRNA-30b to Inhibit Excessive Autophagy and Apoptosis and Attenuates Ischemia/Reperfusion Injury In Vitro and in Patients. ( Cai, S; Cai, W; Chen, X; Li, M; Lu, Y; Lu, Z; Mo, G; Mo, J; Ruan, Z; Shen, J; Tang, J; Yang, Y; Zhang, L, 2022) |
| "To analyze the effect of different doses of propofol on pulmonary function and inflammatory response in patients with lung ischemia reperfusion injury (LIRI) induced by one-lung ventilation (OLV) based on big data analysis." | 4.12 | Effect of Different Doses of Propofol on Pulmonary Function and Inflammatory Response in Patients with Lung Ischemia Reperfusion Injury Induced by One-Lung Ventilation Based on Big Data Analysis. ( Du, B; Gu, T; Gu, Y; Liu, X, 2022) |
| "To verify whether propofol alleviates liver ischemia-reperfusion injury (IRI) in mice by regulating Cyp2b10/ Cyp3a25 pathway." | 4.12 | Protection of propofol on liver ischemia reperfusion injury by regulating Cyp2b10/ Cyp3a25 pathway. ( Sun, C; Wu, J; Xu, Y; Yu, C; Zeng, X, 2022) |
| "This study aimed to investigate the effects of propofol on cardiac function and miR-494 expression in rats with hepatic ischemia/reperfusion (I/R) injury." | 4.02 | Effects of propofol on cardiac function and miR-494 expression in rats with hepatic ischemia/reperfusion injury. ( Lv, J; Ou, W; Sun, C; Yu, C; Zou, X, 2021) |
| "Propofol (PPF) plays a protective role in ischemia-reperfusion (I/R) in multiple organs, including renal ischemia-reperfusion injury (RIRI)." | 4.02 | Propofol attenuates renal ischemia/reperfusion injury by regulating the MALAT1/miR-126-5p axis. ( Hu, Y; Li, A; Li, X; Zhang, Z, 2021) |
| "Propofol (PPF) is reported to play a protective role in ischemia/reperfusion (I/R) injury, including cerebral ischemia-reperfusion injury (CIRI)." | 4.02 | Propofol Downregulates lncRNA MALAT1 to Alleviate Cerebral Ischemia-Reperfusion Injury. ( Chen, J; Cheng, S; Hu, Y; Ye, C, 2021) |
| "To investigate the effect of propofol on the expression and phosphorylation of the skeletal muscle insulin receptor and its substrates following hepatic ischemia-reperfusion injury (HIRI)." | 3.96 | Effect of propofol on the skeletal muscle insulin receptor in rats with hepatic ischemia-reperfusion injury. ( Chen, C; Chen, Z; Liu, C; Wang, X; Zhang, L, 2020) |
| "The aim of this study was to investigate the effects of propofol on intestinal ischemia-reperfusion injury in rats through the nuclear factor-kappa B (NF-κB) pathway." | 3.96 | Propofol improves intestinal ischemia-reperfusion injury in rats through NF-κB pathway. ( Cui, SM; He, SC; Ma, B; Wu, MB; Zhang, TX; Zhao, K, 2020) |
| "Propofol is widely used in general anesthesia, and it has been reported to protect various organs against ischemia-reperfusion injury (IRI), including liver." | 3.96 | Ischemic Preconditioning Protects Against Hepatic Ischemia-Reperfusion Injury Under Propofol Anesthesia in Rats. ( Choi, JW; Gwak, MS; Hahm, TS; Han, S; Jeon, SY; Kim, D; Kim, GS; Ko, JS; Ryu, S, 2020) |
| "Rats underwent 1 h of focal cerebral ischemia followed by 23 h of reperfusion were randomly divided into 6 groups (n = 36 per group): sham- operation (S), ischemia-reperfusion (IR), propofol (P group, propofol 20 mg/kg/h at the onset of reperfusion for 2 h after 60 min of occlusion), and LY294002 (PI3K non-selective antagonist) + sham (L + S, LY294002 of 1." | 3.91 | The role of PI3K-mediated AMPA receptor changes in post-conditioning of propofol in brain protection. ( Dong, B; Shi, Y; Wang, C; Wang, G; Wei, Y; Xie, K; Yu, Y; Yuan, Y, 2019) |
| "Propofol may help to protect against ischaemic acute kidney injury (AKI); however, research on this topic is sparse." | 3.91 | Effect of sevoflurane-based or propofol-based anaesthesia on the incidence of postoperative acute kidney injury: A retrospective propensity score-matched analysis. ( Han, S; Jheon, S; Ji, E; Kim, J; Kim, K; Oh, TK, 2019) |
| " Propofol (2,6-diisopropylphenol) has been proven to attenuate mitochondrial dysfunction and reperfusion injury." | 3.88 | Propofol Prevents Oxidative Stress by Decreasing the Ischemic Accumulation of Succinate in Focal Cerebral Ischemia-Reperfusion Injury. ( Gao, D; Jin, W; Liu, S; Qi, S; Yu, W, 2018) |
| "After approval by the institutional animal care and use committee, 36 Japanese White rabbits underwent partial hepatic ischemia for 90 min either under sevoflurane or propofol anesthesia." | 3.88 | Interaction between anesthetic conditioning and ischemic preconditioning on metabolic function after hepatic ischemia-reperfusion in rabbits. ( Kosugi, S; Kotake, Y; Morisaki, H; Nagata, H; Suzuki, T; Yamada, T, 2018) |
| "This experimental study aims to observe whether the protective effect of propofol against renal ischemia-reperfusion injury (IRI) in the rat interlobar artery occurs through altered expression of the gap junction protein connexin 43 (Cx43)." | 3.88 | The Protective Effect of Propofol Against Ischemia-Reperfusion Injury in the Interlobar Arteries: Reduction of Abnormal Cx43 Expression as a Possible Mechanism. ( Chang, YC; Ji, W; Li, L; Ma, KT; Shan, LY; Shi, WY; Si, JQ; Tan, CY; Wang, Y; Wang, YP; Xue, WJ; Zhang, L, 2018) |
| " The study aimed to estimate the efficacy of estrogen and propofol combination therapy against ERS-induced apoptosis after cerebral ischemia-reperfusion injury and oxygen-glucose deprivation (OGD) injury in the hippocampus in vivo and in vitro." | 3.88 | Estrogen and propofol combination therapy inhibits endoplasmic reticulum stress and remarkably attenuates cerebral ischemia-reperfusion injury and OGD injury in hippocampus. ( Li, Y; Ma, R; Wang, E; Wang, S; Xiong, E; Xu, F; Yin, J; Zhang, G; Zhang, Q, 2018) |
| "Early apoptosis was significantly higher in isoflurane and propofol anesthetized animals subjected to renal ischemia-reperfusion injury when compared to both cyclosporine A treated and sham groups." | 3.85 | Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats. ( Carvalho, LR; Castiglia, YM; Deffune, E; Golim, MA; Lemos, SV; Módolo, NS; Nascimento, PD; Souza, AV; Vianna, IG; Vianna, PT, 2017) |
| "Global brain ischemia-reperfusion during propofol anesthesia provokes persistent cerebral pial constriction." | 3.85 | The effects of Y-27632 on pial microvessels during global brain ischemia and reperfusion in rabbits. ( Asano, N; Ishiyama, T; Kotoda, M; Matsukawa, T; Sessler, DI; Shintani, N, 2017) |
| "Both propofol and sevoflurane attenuated the extent of hepatic ischemia/reperfusion injury which is evident from the hisopathological studies and alterations in liver enzymes such as AST and LDH by inhibiting Nuclear factor kappa B (NFx03BA;B) activation and subsequent alterations in inflammatory cytokines interleukin-1(IL-1), interleukin-6(IL-6), tumor necrosis factor-alpha (TNF-α) and increased IL10 release." | 3.83 | The Effects of Two Anesthetics, Propofol and Sevoflurane, on Liver Ischemia/Reperfusion Injury. ( Qi, F; Wang, H; Wang, Z; Wu, J; Xu, Z; Yu, J, 2016) |
| "To investigate the effect of propofol on the expression of rabbit ischemia-reperfusion injury-related proteins and the mechanism involved." | 3.81 | The effect of propofol on the expression of rabbit ischemia reperfusion injury-related proteins. ( Dong, M; Dong, R; Fang, L; Li, S; Xu, Z, 2015) |
| "Propofol is a commonly used intravenous anesthetic that has been demonstrated to be neuroprotective against cerebral ischemia-reperfusion (I/R) injury." | 3.81 | Propofol prevents neuronal mtDNA deletion and cerebral damage due to ischemia/reperfusion injury in rats. ( Chang, FF; Dong, H; Liu, Y; Lu, SJ; Qian, H; Song, CY; Wang, YF; Yang, WC; Yue, ZY, 2015) |
| "It has been shown in our previous study that propofol postconditioning enhanced the activity of phosphatidylinositol-3-kinase (PI3K) and prevented the internalization of GluR2 subunit of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thus provided neuroprotection in cerebral ischemia/reperfusion (I/R) injury." | 3.81 | The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats. ( Liu, S; Wang, G; Wang, H; Zhu, A, 2015) |
| "Propofol, an intravenous anesthetic, inhibits neuronal apoptosis induced by ischemic stroke, protects the brain from ischemia/reperfusion injury and improves neuronal function." | 3.81 | Propofol post-conditioning protects the blood brain barrier by decreasing matrix metalloproteinase-9 and aquaporin-4 expression and improves the neurobehavioral outcome in a rat model of focal cerebral ischemia-reperfusion injury. ( Cao, MH; Ji, FT; Liang, JJ; Miao, LP; Wu, Q, 2015) |
| "To investigate the protective effect of propofol against focal cerebral ischemia/reperfusion (I/R) injury in rats and its relation with gap junction." | 3.81 | [Protective effect of propofol against cerebral ischemic/reperfusion injury may involve inhibition of gap junction]. ( Chen, Y; Dong, S; Fan, Z; Li, Y; Liu, H; Tong, X; Yu, L, 2015) |
| "The general anesthetic propofol protects the adult heart against ischemia and reperfusion injury; however, its efficacy has not been investigated in the immature heart." | 3.80 | Propofol protects the immature rabbit heart against ischemia and reperfusion injury: impact on functional recovery and histopathological changes. ( Imura, H; Nitta, T; Shirakawa, M, 2014) |
| "Sixty rats were randomly assigned to four groups: normoglycemia-etomidate, normoglycemia-propofol, hyperglycemia-etomidate, and hyperglycemia-propofol." | 3.79 | Propofol attenuates renal ischemia-reperfusion injury aggravated by hyperglycemia. ( Jun, JH; Kwak, YL; Lim, BJ; Shim, JK; Yoo, KJ; Yoo, YC, 2013) |
| "To study the effect of isoflurane (Iso) or propofol (Prop) anesthesia on renal ischemia/reperfusion injury (IRI) during transient hyperglycemia." | 3.79 | Do propofol and isoflurane protect the kidney against ischemia/reperfusion injury during transient hyperglycemia? ( Carraretto, AR; Carvalho, LR; Castiglia, YM; Deffune, E; Golim, Mde A; Souza, AV; Vianna Filho, PT; Vianna, PT, 2013) |
| "To investigate the protective effects of propofol in brain ischemia/reperfusion injury and the role of heme oxygenase-1 (HO-1) in this process." | 3.79 | Propofol attenuates cerebral ischemia/reperfusion injury partially using heme oxygenase-1. ( Cang, J; Liang, C; Wang, H; Xue, Z, 2013) |
| "To observe the effect of resveratrol and propofol, used either alone or in combination, on hepatocyte apoptosis in rats with hepatic ischemia-reperfusion injury (HIRI)." | 3.79 | [Protective effect of propofol and resveratrol pretreatment against hepatocyte apoptosis in rats with hepatic ischemia-reperfusion injury]. ( Liu, L; Liu, T; Shen, X; Wang, R; Zhao, G, 2013) |
| "The antioxidant properties of propofol have been shown to improve ischemia/reperfusion injury." | 3.78 | Propofol prevents lung injury following intestinal ischemia-reperfusion. ( Agrogiannis, G; Kalimeris, K; Kostopanagiotou, G; Nakos, G; Nomikos, T; Perrea, D; Vasileiou, I; Xanthopoulou, MN, 2012) |
| "Our previous clinical study reported that isoflurane preconditioning and high-dose propofol posttreatment attenuated myocardial ischemia/reperfusion injury of patients in surgery with cardiopulmonary bypass (CPB)." | 3.78 | Alternative use of isoflurane and propofol confers superior cardioprotection than using one of them alone in a dog model of cardiopulmonary bypass. ( Irwin, MG; Li, H; Li, Q; Li, T; Liu, J; Wu, W; Xia, Z; Xiang, X; You, Z; Zhou, R; Zhu, D, 2012) |
| "This experimental study aimed to investigate the antioxidant effects of propofol anesthesia at induction doses in a rat skeletal muscle ischemia/reperfusion injury model." | 3.78 | Antioxidant effects of propofol on tourniquet-induced ischemia-reperfusion injury: an experimental study. ( Bostan, B; Erkorkmaz, U; Ozkan, F; Ozyurt, H; Senayli, Y, 2012) |
| "Propofol reduced the tissue damage in rat testes subjected to ischemia-reperfusion caused by spermatic cord torsion." | 3.78 | Propofol effects on the morphology of rat testes subjected to testicular ischemia-reperfusion. ( Inouye, CM; Pontes, JC; Santos, CH; Silva, AC; Silva, GV; Urt Filho, A, 2012) |
| "Propofol has been demonstrated to improve hepatic perfusion in a rabbit model; however, the effects of propofol on hepatic ischemia/reperfusion injury are unknown." | 3.78 | Propofol attenuates hepatic ischemia/reperfusion injury in an in vivo rabbit model. ( Luo, CZ; McCluskey, SA; Pang, QY; Ye, L; Zhu, T, 2012) |
| "Monitoring of exhaled pentane may be useful for evaluating the severity of hepatic ischemia-reperfusion injury and aid in predicting the outcome; propofol may improve the outcome in this situation." | 3.78 | Breath pentane as a potential biomarker for survival in hepatic ischemia and reperfusion injury--a pilot study. ( Gong, Y; He, Y; Li, E; Li, J; Li, P; Liu, D; Liu, S; Luo, A; Shi, J; Sun, B; Wang, C; Xu, G, 2012) |
| "To investigate the protective effect and mechanisms of Fospropofol disodium on in vivo liver ischemia-reperfusion injury in rats." | 3.77 | [Protective effect of fospropofol disodium on in vivo liver ischemia-reperfusion injury in rats]. ( Liu, Y; Luo, CZ, 2011) |
| "Our aim was to investigate the long-term preventive effect of propofol on testicular ischemia-reperfusion injury in a rat model." | 3.77 | Does propofol prevent testicular ischemia-reperfusion injury due to torsion in the long term? ( Cobanoğlu, U; Gör, A; Karagüzel, E; Kutlu, O; Senel, AC; Taşkara, E; Topbaş, M, 2011) |
| "Propofol is an intravenous anesthetic with neuroprotective effects against cerebral ischemia-reperfusion (I/R) injury." | 3.77 | Propofol improved neurobehavioral outcome of cerebral ischemia-reperfusion rats by regulating Bcl-2 and Bax expression. ( Cui, XG; Lu, SJ; Song, CY; Tao, T; Xi, HJ; Yue, ZY; Zhang, TH, 2011) |
| " Research has shown that propofol, which is an intravenous anesthetic agent, exhibits neuroprotective effects against cerebral ischemia-reperfusion injury, although the neuroprotective mechanism is still unclear." | 3.76 | The effects of propofol on hippocampal caspase-3 and Bcl-2 expression following forebrain ischemia-reperfusion in rats. ( Han, B; Li, J; Ma, X; Qi, S, 2010) |
| "Propofol can significantly inhibit the accumulation of EAA in spinal cord and provide a protective effect against the ischemia/reperfusion injury induced spinal cord in rabbits." | 3.75 | [Effect of propofol on spinal excitatory amino acid accumulation]. ( Wang, Q; Weng, H; Yao, J; Zeng, J; Zhang, Y, 2009) |
| "To evaluate the protective effect of hypothermic propofol infused via the aorta against ischemia/reperfusion injury of spinal cords in rabbits." | 3.75 | [Protective effect of hypothermic propofol on ischemic spinal cords]. ( Fang, H; Lin, YJ; Wang, QY; Yao, JY; Zeng, J, 2009) |
| "Propofol preconditioning decreased cardiomyocyte apoptosis, protected the heart against 31 degrees C mild hypothermic ischemia/reperfusion injury by attenuation of the release of cytochrome C from mitochondria to cytosol." | 3.75 | [The effect of propofol preconditioning on cytochrome C release from mitochondria after mild hypothermic ischemia/reperfusion in isolated rat hearts]. ( Wang, HX; Zeng, YM; Zhu, SS, 2009) |
| "To investigate the effect of propofol intra-aortic and intravenous infusion on the concentration of propofol for an ischemia-reperfusion spinal cord injury in rabbits." | 3.74 | [Comparison of propofol concentration in the spinal cord between intra-aortic and intravenous infusion]. ( Liao, Z; Lin, Y; Zhang, J; Zhang, L, 2008) |
| "Use of sevoflurane compared with propofol attenuated the haemodynamic sequelae of reperfusion injury in our model." | 3.74 | Effects of sevoflurane and propofol on ischaemia-reperfusion injury after thoracic-aortic occlusion in pigs. ( Annecke, T; Bittmann, I; Conzen, PF; Hilberath, JM; Kahr, S; Kemming, GI; Kubitz, JC; Langer, K; Rehm, M, 2007) |
| "We have previously demonstrated, in the isolated rat heart, that propofol attenuates hydrogen peroxide-induced damage and ischaemia-reperfusion injury, and that the beneficial effect of propofol is correlated with reduction of the lipid peroxidation." | 3.74 | Propofol attenuates ischaemia-reperfusion injury in the rat heart in vivo. ( Kobayashi, I; Kokita, N; Namiki, A, 2008) |
| "It is still unclear whether propofol may protect the liver against ischemia/ reperfusion injury (IRI) in vivo." | 3.74 | Effects of propofol on early phase of warm hepatic ischemia/reperfusion injury. ( Choi, JH; Jee, D; Kim, JY; Kim, SK, 2007) |
| "To study the therapeutic effect and its mechanisms of propofol on gastric mucosal injury after hemorrhagic shock with reperfusion in rabbits." | 3.74 | [Effect of propofol on gastric mucosal injury after hemorrhagic shock and reperfusion in rabbits]. ( Li, HY; Lü, YX; Wang, LL; Zhang, LF, 2008) |
| "We conclude that the severity of remote lung injury was not different between sevoflurane and propofol anaesthesia in this porcine model of severe lower-body ischaemia and reperfusion injury." | 3.74 | Lung injury following thoracic aortic occlusion: comparison of sevoflurane and propofol anaesthesia. ( Annecke, T; Bittmann, I; Conzen, PF; Hilberath, JM; Kahr, S; Kemming, GI; Krombach, F; Kubitz, JC; Langer, K; Rehm, M, 2008) |
| "To investigate the role of oxygen free radicals (OFR) in hepatic ischemia and reperfusion injury (HI/RI) and effect of propofol on them." | 3.73 | [Effect of propofol on anti-oxidation capability in the ischemia/reperfusion injury after hepatic ischemia in rabbits]. ( Li, D; Lin, LN; Wang, W; Wang, WT, 2005) |
| " The aim of the study was to investigate the preventive effects of thiopental and propofol as anesthetics on testicular ischemia-reperfusion injury." | 3.73 | The preventive effects of thiopental and propofol on testicular ischemia-reperfusion injury. ( Ayyildiz, A; Caydere, M; Germiyanoglu, C; Karaguzel, E; Nuhoglu, B; Ogus, E; Surer, H; Yagmurdur, H, 2006) |
| "To investigate the effects of propofol, midazolam and thiopental sodium on outcomes and amino acid accumulation in focal cerebral ischemia-reperfusion in rats." | 3.72 | Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats. ( Chen, L; Gong, Q; Xiao, C, 2003) |
| "We examined the effect of propofol on the main mechanisms involved in ischemia/reperfusion-induced arrhythmias (i." | 3.72 | Propofol decreases reperfusion-induced arrhythmias in a model of "border zone" between normal and ischemic-reperfused guinea pig myocardium. ( Bricard, H; Ducouret, P; Flais, F; Gérard, JL; Hanouz, JL; Rouet, R; Yvon, A, 2003) |
| "To investigate the protective efficacy of propofol against lung injury during hemorrhagic shock and resuscitation among Rhesus macaques." | 3.71 | [Effect of propofol on protecting Rhesus macaques from reperfusion lung injury during hemorrhagic shock and resuscitation]. ( Huang, X; Song, Q; Wang, M; Zhang, H, 2002) |
| " We measured the levels of malondialdehyde as a marker of lipid peroxidation in ischemic tissue, and the results indicate that propofol plays a role in the inhibition of neuronal death induced by brain ischemia." | 3.71 | Neuroprotective effects of propofol following global cerebral ischemia in rats. ( Akdemir, G; Ergün, R; Ergüngör, F; Sen, S; Taşçi, A, 2002) |
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 3.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "We investigated the effects of selective and non-selective endothelin (ET) antagonists on warm ischemia-reperfusion injury of the early phase in the murine liver under propofol anesthesia." | 3.70 | [Effects of endothelin antagonists on isolated perfused murine livers in the early phase of warm ischemia-reperfusion injury under propofol anesthesia]. ( Karasawa, F; Sato, T; Tanaka, K, 1999) |
| "It has been suggested that propofol has the protective effect on cerebral ischemia-reperfusion injury." | 3.70 | Effectiveness of propofol pretreatment on the extent of deranged cerebral mitochondrial oxidative enzyme system after incomplete forebrain ischemia/reperfusion in rats. ( Chung, C; Lee, Y; Oh, YS, 2000) |
| "This study was designed to test the hypothesis that propofol, which possesses antioxidant properties, would produce greater protection than isoflurane in cerebral ischaemia reperfusion injury, at dose levels that produced similar affects on brain electrical activity." | 3.69 | Propofol neuroprotection in a rat model of ischaemia reperfusion injury. ( Jones, JG; Matta, BF; Menon, DK; Tisavipat, N; Young, Y, 1997) |
| "Malondialdehyde (MDA) is an intermediate metabolite of lipid peroxidation resulting from IR-induced reactive oxygen species." | 2.77 | Propofol attenuates ischemic reperfusion-induced formation of lipid peroxides in liver transplant recipients. ( Lee, WC; Lin, CC; Tsai, YF; Yu, HP, 2012) |
| "Malondialdehyde levels were decreased significantly in group 3 and increased non-significantly in group 2 at the same time points." | 2.71 | The effects of etomidate, thiopental, and propofol in induction on hypoperfusion-reperfusion phenomenon during laparoscopic cholecystectomy. ( Arslan, M; Baltaci, B; Bayrak, A; Cakan, T; Inan, N; Kilinc, K; Yagmurdur, H, 2004) |
| "Propofol could further activate the pathway, which reduced intestinal injury, inhibited apoptosis, reversed inflammation and oxidative stress, and improved the 24-hour survival rate in II/R rats in vivo, and attenuated H/R-induced IEC-6 cell injury, oxidative stress, and apoptosis in vitro, as fine as changes in AICAR treatment." | 1.72 | The role of AMPK-Sirt1-autophagy pathway in the intestinal protection process by propofol against regional ischemia/reperfusion injury in rats. ( Chen, Y; Feng, JG; Jia, J; Liu, X; Tan, YF; Wang, MH; Yang, B; Yang, CJ; Zhou, J, 2022) |
| "Pretreatment with propofol markedly attenuated lung injury (such as reducing the lung edema and permeability), increased MDA content and MPO activity, and restored SOD activity induced by IIR, accompanied by inhibiting the effect of the HMGB1/TLR4/PKR signaling pathway." | 1.62 | Pretreatment with Propofol Reduces Pulmonary Injury in a Pig Model of Intestinal Ischemia-Reperfusion via Suppressing the High-Mobility Group Box 1 Protein (HMGB1)/Toll-Like Receptor 4 (TLR4)/Protein Kinase R (PKR) Signaling Pathway. ( Bian, WY; Chen, YP; Tang, J; Xu, B, 2021) |
| "Stroke is one of the leading causes of mortality and disability worldwide with limited clinical therapies available." | 1.56 | Propofol protects against oxygen/glucose deprivation‑induced cell injury via gap junction inhibition in astrocytes. ( Fan, Y; Wang, J; Wang, X; Zhao, Y; Zhu, S, 2020) |
| "Propofol treatment alleviated intestinal and lung morphological changes which were observed in II/R group，Moreover, wet/dry weight ratio, the MDA level, MPO activity and expression of caspase-3 were significantly decreased whereas the SOD activity and p-Akt expression were significantly increased." | 1.51 | The role of PI3K/Akt signal pathway in the protective effects of propofol on intestinal and lung injury induced by intestinal ischemia/reperfusion1. ( Cui, S; Ding, H; He, X; Jing, G; Li, Q; Xia, Z, 2019) |
| "Desflurane had lower uptake than propofol (65 ± 21 × 10 vs 165 ± 51 × 10 g·mL·min/μmol; P = ." | 1.48 | Propofol Attenuates the Myocardial Protection Properties of Desflurane by Modulating Mitochondrial Permeability Transition. ( Andrews, DT; Heiberg, J; Royse, AG; Royse, CF, 2018) |
| "Propofol could activate YAP through dephosphorylation." | 1.48 | Propofol Protects Hippocampal Neurons from Hypoxia-Reoxygenation Injury by Decreasing Calcineurin-Induced Calcium Overload and Activating YAP Signaling. ( Cai, H; Li, X; Liang, Q; Qu, H; Yao, L, 2018) |
| "It has been recognized to be critical in cerebral ischemia-reperfusion injury, and reactive oxygen species (ROS) can induce parthanatos." | 1.48 | Propofol inhibits parthanatos via ROS-ER-calcium-mitochondria signal pathway in vivo and vitro. ( Chen, Y; Hu, J; Liu, Y; Liu, Z; Pang, Q; Song, R; Tang, J; Zhong, H; Zhuang, J, 2018) |
| "Pretreatment with propofol attenuates autogenous orthotropic liver transplantation induces hippocampal injury via JAK2/STAT3 pathway." | 1.46 | Propofol postconditioning attenuates hippocampus ischemia-reperfusion injury via modulating JAK2/STAT3 pathway in rats after autogenous orthotropic liver transplantation. ( Du, H; Gu, X; Jia, L; Li, S; Sheng, M; Wang, F; Wang, G; Weng, Y; Yu, W, 2017) |
| "Propofol has been found to play an important role in hepatic ischemia/reperfusion (I/R) injury with the antioxidant effects." | 1.46 | Propofol protects against hepatic ischemia/reperfusion injury via miR-133a-5p regulating the expression of MAPK6. ( Hao, W; Lei, SQ; Meng, QT; Tie, ME; Xia, ZY; Zhao, ZH, 2017) |
| "Propofol could inhibit mitochondrial fission and mitochondrial apoptotic pathway evoked by OGD/R in rat hippocampal neurons, which may be via depressing calcium-overload." | 1.43 | The Effect of Propofol on Mitochondrial Fission during Oxygen-Glucose Deprivation and Reperfusion Injury in Rat Hippocampal Neurons. ( Guo, Y; Jia, C; Liu, M; Wang, H; Wang, S; Wang, X; Xue, S; Zheng, S, 2016) |
| "Propofol was reported to attenuate endothelial adhesion molecule expression in some situations." | 1.42 | Propofol ameliorates endothelial inflammation induced by hypoxia/reoxygenation in human umbilical vein endothelial cells: Role of phosphatase A2. ( Chen, J; Ding, J; Jiang, H; Kong, L; Miao, C; Sun, Z; Zhu, M, 2015) |
| "Propofol pretreated IR rats had lower Bax/Bcl-2 ratio and less cleaved caspase-3." | 1.42 | Propofol Prevents Renal Ischemia-Reperfusion Injury via Inhibiting the Oxidative Stress Pathways. ( Jia, Y; Lei, L; Li, Y; Yang, B; Zhong, D; Zhou, H, 2015) |
| "Propofol has been shown to attenuate brain injury in experimental ischemia models, but few studies have focused on the direct effect of propofol on mitochondrial dysfunction." | 1.40 | The effects of propofol on mitochondrial dysfunction following focal cerebral ischemia-reperfusion in rats. ( Li, B; Li, J; Li, XT; Qi, SH; Yu, W, 2014) |
| "Propofol has protective effects against IR-induced lung injury by improving activity of oxygen radical and restoring NO/ET-1 dynamic balance." | 1.40 | The significance and mechanism of propofol on treatment of ischemia reperfusion induced lung injury in rats. ( Xu, X; Yang, N; Yang, P; Zhang, X, 2014) |
| "Pretreatment with propofol in conditions of hepatic I/R inhibits the apoptosis of hepatocytes as evidenced by decreased terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells." | 1.39 | Role of glycogen synthase kinase 3β in protective effect of propofol against hepatic ischemia-reperfusion injury. ( Chen, B; Lv, Y; Ma, H; Qu, P; Shen, X; Tie, R; Xu, GF; Yu, J; Zhang, H; Zhao, G; Zhu, YL, 2013) |
| "Propofol post-treatment also attenuated brain water content at 24 and 72 h and reduced neurologic deficit score at 72 h and 7 days of reperfusion (all P < 0." | 1.39 | Propofol increases expression of basic fibroblast growth factor after transient cerebral ischemia in rats. ( An, P; Chen, WM; Jiang, C; Tong, DY; Wang, J; Zhang, LM; Zhao, P; Zhao, XC, 2013) |
| "Treatment with propofol during organ preservation did not reduce neutrophil infiltration into the graft." | 1.37 | Addition of a water-soluble propofol formulation to preservation solution in experimental kidney transplantation. ( Buurman, WA; de Vries, EE; Haenen, GR; Parkkinen, J; Peutz-Kootstra, CJ; Schurink, GW; Snoeijs, MG; Vaahtera, L; van Heurn, LW, 2011) |
| "Ischemia-induced adverse effects such as pulmonary edema and acute brain swelling were observed primarily in propofol-anesthetized rabbits." | 1.36 | Cerebral pial vascular changes under propofol or sevoflurane anesthesia during global cerebral ischemia and reperfusion in rabbits. ( Ichikawa, M; Ishiyama, T; Kiuchi, R; Masamune, T; Matsukawa, T; Sessler, DI; Shibuya, K, 2010) |
| " When combined with reserpine (40 micromol/L), different concentrations of propofol (12." | 1.35 | [Protective effects of propofol combined with reserpine on cultured PC12 cells impaired by ischemia and reperfusion]. ( Cao, JB; Li, YF; Mi, WD; Wang, HL, 2008) |
| "Remote pulmonary dysfunction and reperfusion injury in the liver were demonstrated in our rat model, as well as massive ROS production and lipid peroxidation." | 1.35 | Propofol attenuates the decrease of dynamic compliance and water content in the lung by decreasing oxidative radicals released from the reperfused liver. ( Chan, KC; Chen, CF; Cheng, YJ; Lai, YL; Lee, PH; Lin, CJ; Sun, WZ, 2008) |
| "Propofol pretreatment significantly attenuated these changes (all P < 0." | 1.35 | Propofol pretreatment reduces ceramide production and attenuates intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion in rats. ( Chen, SQ; Huang, WQ; Irwin, MG; Li, YS; Liu, KX; Xia, Z, 2008) |
| "Cerebral edema is a major threat for stroke victims." | 1.35 | Propofol pretreatment attenuates aquaporin-4 over-expression and alleviates cerebral edema after transient focal brain ischemia reperfusion in rats. ( Lan, YP; Tang, HF; Zheng, YY; Zhu, SM, 2008) |
| "Treatment with propofol has been found to attenuate oxidative stress and prevent ischemia/reperfusion injury in rat heart." | 1.35 | Propofol protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via Akt activation and Bcl-2 up-regulation. ( Ansley, DM; Chen, DD; Luo, H; Raedschelders, K; Shravah, J; Wang, B, 2009) |
| "Rats underwent 2 h of middle cerebral artery occlusion (MCAO) followed by 22 h of reperfusion were randomly divided into nine groups (n=15 each): sham-operated group, MCAO group, propofol 10, 20 and 35 mg x kg(-1) x h(-1) group (propofol 10, 20, 35 mg x kg(-1) x h(-1) infused at the onset of reperfusion for 30 min), wortmannin group (wortmannin 0." | 1.35 | The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats. ( Wang, GL; Wang, HY; Wang, Y; Yu, YH, 2009) |
| "Propofol treatments were initiated at various time intervals: 1 or 24 h before ischemia, only during ischemia, or only during reperfusion." | 1.35 | The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion. ( Assad, AR; Capella, MA; Delou, JM; Fonseca, LM; Lopes, AG; Nascimento, JH; Verçosa, N; Villela, NR, 2009) |
| "Propofol was added during the OGD phase of the model." | 1.35 | Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation. ( Pan, CF; Xiong, XX; Zheng, YY; Zhu, SM, 2009) |
| "Groups 1 and 3 (control groups) had no testicular torsion and detorsion." | 1.35 | Propofol reduces nitric oxide-induced apoptosis in testicular ischemia-reperfusion injury by downregulating the expression of inducible nitric oxide synthase. ( Akgul, T; Ayyildiz, A; Germiyanoglu, C; Karaguzel, E; Ustun, H; Yagmurdur, H, 2008) |
| "Propofol has been demonstrated to ameliorate cerebral ischemic injury and attenuate changes in multiple links of molecular reaction included in the paths to apoptosis." | 1.35 | Effect of propofol on pathologic time-course and apoptosis after cerebral ischemia-reperfusion injury. ( Chen, L; Jiang, H; Xue, Z, 2008) |
| "Propofol were infused through aorta distal to the occlude sites of the rabbits in the Propofol infusion group continuously with a pump at a rate of 50 mg/kg x 30 min." | 1.35 | [Effect of propofol aortic infusion on ischemia-reperfusion spinal cords of rabbits]. ( Liao, ZM; Lin, YJ; Zhang, JF; Zhang, L, 2008) |
| "Propofol treatments, especially pre-treatment, significantly reduced Chiu's scores and levels of MDA, NO, ET-1 and LD, while restoring SOD activity." | 1.34 | Propofol attenuates intestinal mucosa injury induced by intestinal ischemia-reperfusion in the rat. ( He, W; Liu, KX; Rinne, T; Wang, F; Xia, Z, 2007) |
| "ICAM-1 plays an important role in lung injury after intestinal I/R." | 1.33 | [Propofol reduces intercellular adhesion molecular-1 expression in lung injury following intestinal ischemia/reperfusion in rats]. ( Hu, XM; Lu, Y; Yao, SL, 2005) |
| "Propofol treatment attenuated the changes in myocardial tissue levels of adenine nucleotides, lactate, and amino acids during ischemia and reduced cardiac troponin I release on reperfusion." | 1.33 | Propofol is cardioprotective in a clinically relevant model of normothermic blood cardioplegic arrest and cardiopulmonary bypass. ( Angelini, GD; Halestrap, AP; Lim, KH; Suleiman, MS, 2005) |
| "Propofol has antioxidant properties in vitro which might abrogate this inflammation." | 1.33 | The influence of propofol on P-selectin expression and nitric oxide production in re-oxygenated human umbilical vein endothelial cells. ( Corcoran, TB; Engel, A; O'Shea, A; Shorten, GD, 2006) |
| "Pretreatment with propofol prevented a further increase in MDA levels and significantly decreased CAT activity following detorsion." | 1.32 | Propofol attenuates reperfusion injury after testicular torsion and detorsion. ( Balbay, MD; Bozoklu, A; Devrim, E; Durak, I; Eroglu, M; Guven, C; Unsal, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (3.74) | 18.2507 |
| 2000's | 60 (32.09) | 29.6817 |
| 2010's | 92 (49.20) | 24.3611 |
| 2020's | 28 (14.97) | 2.80 |
| Authors | Studies |
|---|---|
| Xing, D | 2 |
| Li, Q | 3 |
| Lin, G | 1 |
| Lin, H | 1 |
| Kang, W | 1 |
| Zhang, M | 1 |
| Ding, R | 1 |
| Li, N | 1 |
| Li, T | 2 |
| Zeng, QS | 1 |
| She, SZ | 1 |
| Lu, Z | 2 |
| Shen, J | 1 |
| Chen, X | 1 |
| Ruan, Z | 2 |
| Cai, W | 2 |
| Cai, S | 2 |
| Li, M | 1 |
| Yang, Y | 3 |
| Mo, J | 1 |
| Mo, G | 1 |
| Lu, Y | 2 |
| Tang, J | 3 |
| Zhang, L | 7 |
| Liu, Z | 4 |
| Li, C | 2 |
| Li, Y | 9 |
| Yu, L | 5 |
| Qu, M | 1 |
| Gu, Y | 1 |
| Liu, X | 2 |
| Gu, T | 1 |
| Du, B | 1 |
| Kang, H | 1 |
| Chen, J | 5 |
| Cao, S | 1 |
| Yang, B | 3 |
| Tan, YF | 1 |
| Feng, JG | 1 |
| Jia, J | 1 |
| Yang, CJ | 1 |
| Chen, Y | 3 |
| Wang, MH | 1 |
| Zhou, J | 2 |
| Wu, J | 2 |
| Yu, C | 2 |
| Zeng, X | 1 |
| Xu, Y | 1 |
| Sun, C | 2 |
| Fan, GB | 3 |
| Xu, GS | 3 |
| Zhao, AY | 3 |
| Jin, HJ | 3 |
| Sun, SQ | 3 |
| Qi, SH | 4 |
| Luo, J | 1 |
| Liu, J | 2 |
| Mou, Y | 1 |
| Luo, F | 1 |
| Liao, Q | 1 |
| Liao, Y | 1 |
| Li, J | 5 |
| Wang, R | 2 |
| Chen, H | 3 |
| Yang, X | 1 |
| Wang, W | 2 |
| Fang, H | 3 |
| Zhang, FX | 1 |
| Li, HF | 1 |
| Yang, M | 2 |
| Liao, R | 1 |
| Wang, RR | 1 |
| Wang, QY | 2 |
| Zheng, PC | 1 |
| Zhang, JP | 2 |
| Wang, C | 2 |
| Wei, Y | 1 |
| Yuan, Y | 1 |
| Yu, Y | 1 |
| Xie, K | 2 |
| Dong, B | 1 |
| Shi, Y | 1 |
| Wang, G | 5 |
| Wu, ZF | 1 |
| Lin, WL | 1 |
| Lee, MS | 1 |
| Hung, NK | 1 |
| Huang, YS | 1 |
| Chen, TW | 1 |
| Lu, CH | 1 |
| Chen, Z | 1 |
| Liu, C | 1 |
| Wang, X | 4 |
| Chen, C | 5 |
| Hausburg, MA | 1 |
| Banton, KL | 1 |
| Roman, PE | 1 |
| Salgado, F | 1 |
| Baek, P | 1 |
| Waxman, MJ | 1 |
| Tanner, A | 1 |
| Yoder, J | 1 |
| Bar-Or, D | 1 |
| Wu, S | 2 |
| Yao, W | 5 |
| Huang, F | 1 |
| Liu, Y | 6 |
| Cai, J | 2 |
| Yuan, D | 4 |
| Hei, Z | 6 |
| Zhang, J | 3 |
| Zhang, F | 1 |
| Chang, Y | 2 |
| Maldonado, F | 1 |
| Morales, D | 1 |
| Gutiérrez, R | 1 |
| Barahona, M | 1 |
| Cerda, O | 1 |
| Cáceres, M | 1 |
| Wu, MB | 1 |
| Ma, B | 1 |
| Zhang, TX | 1 |
| Zhao, K | 1 |
| Cui, SM | 1 |
| He, SC | 1 |
| Kim, D | 1 |
| Choi, JW | 1 |
| Han, S | 2 |
| Gwak, MS | 1 |
| Kim, GS | 1 |
| Jeon, SY | 1 |
| Ryu, S | 1 |
| Hahm, TS | 1 |
| Ko, JS | 1 |
| Fan, Y | 1 |
| Zhu, S | 1 |
| Wang, J | 2 |
| Zhao, Y | 1 |
| Ma, H | 2 |
| Li, Z | 1 |
| Gao, Y | 1 |
| Ye, X | 2 |
| Li, H | 3 |
| Shi, J | 2 |
| Lv, J | 1 |
| Zou, X | 1 |
| Ou, W | 2 |
| Li, X | 2 |
| Zhang, Z | 1 |
| Li, A | 1 |
| Hu, Y | 2 |
| Bian, WY | 1 |
| Chen, YP | 1 |
| Xu, B | 1 |
| Feng, C | 1 |
| Qian, D | 1 |
| Zhang, WJ | 1 |
| Sun, B | 2 |
| Ou, H | 1 |
| Ren, F | 1 |
| Guan, Y | 1 |
| Huan, Y | 1 |
| Cai, H | 2 |
| Ye, C | 1 |
| Cheng, S | 1 |
| Lemos, SV | 1 |
| Vianna, IG | 1 |
| Castiglia, YM | 2 |
| Golim, MA | 1 |
| Souza, AV | 2 |
| Carvalho, LR | 2 |
| Deffune, E | 2 |
| Nascimento, PD | 1 |
| Módolo, NS | 1 |
| Vianna, PT | 2 |
| Zheng, Y | 1 |
| Bu, J | 1 |
| Liu, H | 3 |
| Nieuwenhuijs-Moeke, GJ | 1 |
| Nieuwenhuijs, VB | 1 |
| Seelen, MAJ | 1 |
| Berger, SP | 1 |
| van den Heuvel, MC | 1 |
| Burgerhof, JGM | 1 |
| Ottens, PJ | 1 |
| Ploeg, RJ | 1 |
| Leuvenink, HGD | 1 |
| Struys, MMRF | 1 |
| Wu, H | 2 |
| Liu, M | 2 |
| Yang, C | 1 |
| Ge, M | 3 |
| Zhu, Q | 1 |
| Jin, Y | 1 |
| Yang, CY | 1 |
| Liu, SY | 1 |
| Wang, HY | 2 |
| Li, YL | 1 |
| Guo, D | 2 |
| Wang, XY | 1 |
| Hua, W | 2 |
| Wang, GL | 2 |
| Su, M | 1 |
| Ren, S | 1 |
| Zhong, W | 1 |
| Han, X | 2 |
| Wei, L | 1 |
| Chen, WY | 1 |
| Hu, T | 1 |
| Tang, YX | 1 |
| Pan, BB | 1 |
| Jin, M | 1 |
| Kong, GY | 1 |
| Eroglu, T | 1 |
| Bozkurt, M | 1 |
| Kapi, E | 1 |
| Selcuk, CT | 1 |
| Kuvat, SV | 1 |
| Tufek, A | 1 |
| Isik, FB | 1 |
| Bozarslan, BH | 1 |
| Firat, U | 1 |
| Satici, O | 1 |
| Li Volti, G | 2 |
| Avola, R | 1 |
| Tibullo, D | 1 |
| Yu, W | 3 |
| Gao, D | 1 |
| Jin, W | 1 |
| Liu, S | 3 |
| Qi, S | 2 |
| Yu, X | 1 |
| Sun, X | 1 |
| Zhao, M | 1 |
| Hou, Y | 2 |
| Yu, J | 3 |
| Liang, J | 1 |
| Du, Y | 1 |
| Feng, D | 1 |
| Zhang, X | 3 |
| Hu, Z | 2 |
| Wang, H | 7 |
| Tang, Q | 1 |
| Miao, L | 1 |
| Yamada, T | 1 |
| Nagata, H | 1 |
| Kosugi, S | 1 |
| Suzuki, T | 1 |
| Morisaki, H | 1 |
| Kotake, Y | 1 |
| Heiberg, J | 1 |
| Royse, CF | 1 |
| Royse, AG | 1 |
| Andrews, DT | 1 |
| Yao, L | 1 |
| Liang, Q | 1 |
| Qu, H | 1 |
| Zhong, H | 1 |
| Song, R | 1 |
| Pang, Q | 1 |
| Zhuang, J | 1 |
| Hu, J | 2 |
| Chang, YC | 1 |
| Xue, WJ | 1 |
| Ji, W | 1 |
| Wang, Y | 3 |
| Wang, YP | 2 |
| Shi, WY | 1 |
| Shan, LY | 1 |
| Tan, CY | 1 |
| Ma, KT | 1 |
| Li, L | 1 |
| Si, JQ | 1 |
| Xu, F | 1 |
| Ma, R | 1 |
| Zhang, G | 1 |
| Wang, S | 2 |
| Yin, J | 1 |
| Wang, E | 1 |
| Xiong, E | 1 |
| Zhang, Q | 2 |
| Zhang, Y | 2 |
| Guan, J | 1 |
| Luo, G | 2 |
| Huang, P | 1 |
| Nguyen, TM | 1 |
| Fleyfel, M | 1 |
| Boleslawski, E | 1 |
| M'Ba, L | 1 |
| Geniez, M | 1 |
| Ethgen, S | 1 |
| Béhal, H | 1 |
| Lebuffe, G | 1 |
| Cui, S | 1 |
| Jing, G | 1 |
| Ding, H | 1 |
| Xia, Z | 5 |
| He, X | 1 |
| Roh, GU | 1 |
| Song, Y | 1 |
| Park, J | 1 |
| Ki, YM | 1 |
| Han, DW | 1 |
| Wei, Q | 1 |
| Zhao, J | 1 |
| Zhou, X | 1 |
| Shin, S | 1 |
| Joo, DJ | 1 |
| Kim, MS | 1 |
| Bae, MI | 1 |
| Heo, E | 1 |
| Lee, JS | 1 |
| Kim, DW | 1 |
| Yoo, YC | 2 |
| Oh, TK | 1 |
| Kim, J | 1 |
| Kim, K | 1 |
| Jheon, S | 1 |
| Ji, E | 1 |
| Ma, K | 1 |
| Qiu, J | 1 |
| Zhou, M | 1 |
| Yoo, KJ | 1 |
| Lim, BJ | 1 |
| Jun, JH | 1 |
| Shim, JK | 1 |
| Kwak, YL | 1 |
| Carraretto, AR | 1 |
| Vianna Filho, PT | 1 |
| Golim, Mde A | 1 |
| Liang, C | 1 |
| Cang, J | 1 |
| Xue, Z | 2 |
| Zhao, G | 2 |
| Shen, X | 2 |
| Xu, GF | 1 |
| Zhu, YL | 1 |
| Chen, B | 1 |
| Tie, R | 1 |
| Qu, P | 1 |
| Lv, Y | 1 |
| Zhang, H | 3 |
| Özkan, D | 1 |
| Akkaya, T | 1 |
| Yalcindag, A | 1 |
| Hanci, T | 1 |
| Gönen, E | 1 |
| Gümüs, H | 1 |
| Delibas, N | 1 |
| Li, XT | 1 |
| Li, B | 1 |
| Gogus, N | 1 |
| Akan, B | 1 |
| Bayrakci, S | 1 |
| Girgin, G | 1 |
| Baydar, M | 1 |
| Erturk, E | 3 |
| Topaloglu, S | 1 |
| Dohman, D | 1 |
| Kutanis, D | 1 |
| Beşir, A | 2 |
| Demirci, Y | 1 |
| Kayir, S | 1 |
| Mentese, A | 2 |
| Zhao, W | 1 |
| Zhou, S | 1 |
| Gan, X | 2 |
| Su, G | 2 |
| Yang, P | 1 |
| Yang, N | 1 |
| Xu, X | 1 |
| Shirakawa, M | 1 |
| Imura, H | 1 |
| Nitta, T | 1 |
| Rancan, L | 2 |
| Huerta, L | 1 |
| Cusati, G | 1 |
| Erquicia, I | 1 |
| Isea, J | 1 |
| Paredes, SD | 1 |
| García, C | 1 |
| Garutti, I | 2 |
| Simón, C | 2 |
| Vara, E | 2 |
| Xu, Z | 2 |
| Dong, M | 1 |
| Fang, L | 1 |
| Dong, R | 1 |
| Li, S | 3 |
| Yue, ZY | 3 |
| Dong, H | 2 |
| Wang, YF | 1 |
| Song, CY | 3 |
| Yang, WC | 2 |
| Qian, H | 2 |
| Lu, SJ | 2 |
| Chang, FF | 1 |
| Zhu, A | 1 |
| Ucar, M | 1 |
| Ozgül, U | 1 |
| Polat, A | 1 |
| Toprak, HI | 1 |
| Erdogan, MA | 1 |
| Aydogan, MS | 1 |
| Durmus, M | 1 |
| Ersoy, MO | 1 |
| Ji, FT | 1 |
| Liang, JJ | 1 |
| Miao, LP | 1 |
| Wu, Q | 1 |
| Cao, MH | 1 |
| Chi, X | 1 |
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| Ding, J | 1 |
| Jiang, H | 2 |
| Kong, L | 1 |
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| Irwin, MG | 3 |
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| Coskun, I | 1 |
| Eroglu, A | 1 |
| Ulusoy, H | 2 |
| Karahan, C | 1 |
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| Zeng, J | 2 |
| Yao, J | 1 |
| Wang, Q | 1 |
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| Raedschelders, K | 2 |
| Hui, Y | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery. A Randomized Controlled Trial[NCT03772054] | 16 participants (Actual) | Interventional | 2018-12-20 | Completed | |||
| "Volatile Anesthetic Protection Of Renal Transplants: VAPOR-1-trail"[NCT01248871] | 120 participants (Actual) | Interventional | 2010-09-30 | Completed | |||
| [NCT02504138] | Phase 4 | 136 participants (Actual) | Interventional | 2014-06-30 | Completed | ||
| Sevoflurane Protective Effect on Ischemia-reperfusion Injury in Patients Undergoing Reconstructive Plastic Surgery With Microsurgical Flap. Multicenter, Randomized Controlled Trial.[NCT01905501] | 132 participants (Actual) | Interventional | 2013-02-28 | Completed | |||
| Changes of Hemodynamics and Vital Organ Function in Intracerebral Hemorrhage During Different General Anesthesia[NCT03129009] | 90 participants (Anticipated) | Interventional | 2017-04-01 | Recruiting | |||
| Clonidine for Tourniquet-related Pain in Children: A Pilot Study[NCT04564430] | Phase 4 | 20 participants (Anticipated) | Interventional | 2021-03-01 | Recruiting | ||
| Effects on Bleeding in Knee Arthroplasty After Ischemic Preconditioning With Sevoflurane[NCT03379103] | 30 participants (Actual) | Interventional | 2018-02-02 | Completed | |||
| Delirium Reduction by Volatile Anesthesia in Cardiac Surgery: Prospective, Randomized, Single-blinded Study[NCT03729011] | Phase 4 | 672 participants (Anticipated) | Interventional | 2019-01-09 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for propofol and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Effects of propofol on ischemia-reperfusion and traumatic brain injury.
Topics: Anesthesia; Anesthetics; Animals; Apoptosis; Astrocytes; Brain; Brain Injuries, Traumatic; Disease M | 2020 |
A meta-analysis and systematic review of propofol on liver ischemia-reperfusion injury protection during hepatocellular carcinoma anesthesia surgery.
Topics: Anesthesia; Carcinoma, Hepatocellular; China; Humans; Liver; Liver Neoplasms; Propofol; Reperfusion | 2021 |
28 trials available for propofol and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
Limb Remote Ischemic Preconditioning Applied During Sevoflurane Anesthesia Does Not Protect the Lungs in Patients Undergoing Adult Heart Valve Surgery.
Topics: Adult; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Aorta; Bronchoalveolar Lavage; Const | 2021 |
Propofol vs desflurane on the cytokine, matrix metalloproteinase-9, and heme oxygenase-1 response during living donor liver transplantation: A pilot study.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Desflurane; Female; Heme Oxygenase-1; Huma | 2019 |
Connexin 32 deficiency protects the liver against ischemia/reperfusion injury.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Connexins; Disease Models, Animal; Gap Junction b | 2020 |
Effect of sevoflurane and propofol on tourniquet-induced endothelial damage: a pilot randomized controlled trial for knee-ligament surgery.
Topics: Adult; Endothelium; Glycocalyx; Heparitin Sulfate; Humans; Knee; Ligaments; Pilot Projects; Propofol | 2020 |
Propofol-based anaesthesia versus sevoflurane-based anaesthesia for living donor kidney transplantation: results of the VAPOR-1 randomized controlled trial.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anest | 2017 |
Propofol post-conditioning alleviates hepatic ischaemia reperfusion injury via BRG1-mediated Nrf2/HO-1 transcriptional activation in human and mice.
Topics: Adolescent; Adult; Aged; Animals; Antioxidants; Cell Line; DNA Helicases; Drug Repositioning; Female | 2017 |
Propofol post-conditioning after temporary clipping reverses oxidative stress in aneurysm surgery.
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Brain; Female; Humans; Intracranial Aneurys | 2019 |
Effects of propofol on the inflammatory response during robot-assisted laparoscopic radical prostatectomy: a prospective randomized controlled study.
Topics: Humans; Inflammation; Kidney; Laparoscopy; Male; Middle Aged; Propofol; Prospective Studies; Prostat | 2019 |
Propofol intravenous anaesthesia with desflurane compared with desflurane alone on postoperative liver function after living-donor liver transplantation: A randomised controlled trial.
Topics: Adult; Allografts; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Desfluran | 2019 |
Propofol sedation in total knee replacement : effects on oxidative stress and ischemia-reperfusion damage.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Arthroplasty, Replacement, Knee; Conscious Sedation; D | 2013 |
The effects of a small-dose ketamine-propofol combination on tourniquet-induced ischemia-reperfusion injury during arthroscopic knee surgery.
Topics: Adult; Analgesics; Anesthesia, Spinal; Anesthetics, Combined; Anesthetics, Intravenous; Arthroscopy; | 2014 |
The comparison of the effects of sevoflurane inhalation anesthesia and intravenous propofol anesthesia on oxidative stress in one lung ventilation.
Topics: Administration, Intravenous; Adolescent; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Doub | 2014 |
Comparison of antioxidant effects of isoflurane and propofol in patients undergoing donor hepatectomy.
Topics: Adolescent; Adult; Aged; Anesthesia; Antioxidants; Biomarkers; Female; Hepatectomy; Humans; Isoflura | 2015 |
Protective effect of sevoflurane preconditioning on ischemia-reperfusion injury in patients undergoing reconstructive plastic surgery with microsurgical flap, a randomized controlled trial.
Topics: Adult; Anesthetics, Inhalation; Biomarkers; Female; Humans; Ischemic Preconditioning; Mammaplasty; M | 2016 |
Comparison of the effect of propofol and N-acetyl cysteine in preventing ischaemia-reperfusion injury.
Topics: Acetylcysteine; Adolescent; Adult; Aged; Anesthesia, Spinal; Anesthetics, Intravenous; Blood Gas Ana | 2009 |
Target-achieved propofol concentration during on-pump cardiac surgery: a pilot dose-finding study.
Topics: Aged; Anesthetics, Intravenous; Blood Pressure; Cardiac Output; Coronary Artery Bypass; Dose-Respons | 2009 |
Propofol attenuates ischemic reperfusion-induced formation of lipid peroxides in liver transplant recipients.
Topics: Adult; Anesthetics, Intravenous; Biomarkers; Humans; Lipid Peroxidation; Lipid Peroxides; Liver Tran | 2012 |
Tourniquet-induced ischemia-reperfusion injuries during extremity surgery at children's age: impact of anesthetic chemical structure.
Topics: Adolescent; Anesthesia, Conduction; Anesthesia, Intravenous; Anesthetics, Inhalation; Antioxidants; | 2013 |
[Protective effect of propofol on liver during ischemia-reperfusion injury in patients undergoing liver surgery].
Topics: Adult; Carboxypeptidases; Female; Free Radical Scavengers; Humans; Lipid Peroxides; Liver; Liver Neo | 2004 |
The effects of etomidate, thiopental, and propofol in induction on hypoperfusion-reperfusion phenomenon during laparoscopic cholecystectomy.
Topics: Adult; Alanine Transaminase; Alkaline Phosphatase; Analysis of Variance; Anesthetics, Intravenous; A | 2004 |
[Protective effect of ligustrazine and propofol on peri-operational liver ischemia-reperfusion injury].
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Drug Therapy, Combination; Female; Humans; Lipid Peroxides; Liv | 2006 |
Propofol and tourniquet induced ischaemia reperfusion injury in lower extremity operations.
Topics: Adult; Analysis of Variance; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2007 |
The effects of propofol or sevoflurane on free radical production after tourniquet induced ischaemia-reperfusion injury during knee arthroplasty.
Topics: Aged; Analysis of Variance; Anesthetics, Inhalation; Anesthetics, Intravenous; Arthroplasty, Replace | 2007 |
Time course and attenuation of ischaemia-reperfusion induced oxidative injury by propofol in human renal transplantation.
Topics: Aged; Anesthetics, Intravenous; Antioxidants; F2-Isoprostanes; Female; Humans; Inflammation; Kidney | 2007 |
Sevoflurane but not propofol increases interstitial glycolysis metabolites availability during tourniquet-induced ischaemia-reperfusion.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Inhalation; Anesthetics, Intravenous; Female; Glucose; | 2008 |
Propofol attenuates formation of lipid peroxides in tourniquet-induced ischaemia-reperfusion injury.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Elective Surgical Procedures; Extremities; | 1997 |
The effects of propofol or halothane on free radical production after tourniquet induced ischaemia-reperfusion injury during knee arthroplasty.
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Arthroplasty; Blood Pressure; Carbon Dioxid | 2001 |
Small-dose propofol sedation attenuates the formation of reactive oxygen species in tourniquet-induced ischemia-reperfusion injury under spinal anesthesia.
Topics: Aged; Anesthesia, Spinal; Arthroplasty, Replacement, Knee; Female; Free Radical Scavengers; Humans; | 2002 |
157 other studies available for propofol and Injury, Ischemia-Reperfusion
| Article | Year |
|---|---|
The protective effects of propofol against renal ischemia-reperfusion injury are potentiated by norisoboldine treatment via inhibition of oxidative stress pathways.
Topics: Alkaloids; Animals; Kidney; Kidney Diseases; Male; Oxidative Stress; Propofol; Rats; Rats, Sprague-D | 2022 |
Propofol Upregulates MicroRNA-30b to Inhibit Excessive Autophagy and Apoptosis and Attenuates Ischemia/Reperfusion Injury In Vitro and in Patients.
Topics: Apoptosis; Autophagy; Beclin-1; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia; Ischemia; M | 2022 |
Propofol Reduces Renal Ischemia Reperfusion-mediated Necroptosis by Up-regulation of SIRT1 in Rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Apoptosis; Caspase 3; Cytokines; Ischemia; Kidney Diseases | 2022 |
Effect of Different Doses of Propofol on Pulmonary Function and Inflammatory Response in Patients with Lung Ischemia Reperfusion Injury Induced by One-Lung Ventilation Based on Big Data Analysis.
Topics: Data Analysis; Humans; Lung; One-Lung Ventilation; Propofol; Reperfusion Injury; Retrospective Studi | 2022 |
Propofol Regulates the Expression of BecliN-1 through miR-30b and Protects against Lung Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis; Beclin-1; Lung; Male; MicroRNAs; Propofol; Rats; Rats, Sprague-Dawley; Reperfusi | 2022 |
The role of AMPK-Sirt1-autophagy pathway in the intestinal protection process by propofol against regional ischemia/reperfusion injury in rats.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Inflammation; Intestinal Diseases; Int | 2022 |
Protection of propofol on liver ischemia reperfusion injury by regulating Cyp2b10/ Cyp3a25 pathway.
Topics: Animals; Apoptosis; Liver; Mice; Propofol; Reperfusion Injury; RNA, Messenger; RNA, Small Interferin | 2022 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol improves ischemia reperfusion-induced liver fibrosis by regulating lncRNA HOXA11-AS.
Topics: Animals; Inflammation; Ischemia; Liver; Liver Cirrhosis; Mice; Propofol; Reperfusion; Reperfusion In | 2023 |
Propofol Pretreatment Inhibits Liver Damage in Mice with Hepatic Ischemia/Reperfusion Injury and Protects Human Hepatocyte in Hypoxia/Reoxygenation.
Topics: Animals; Aspartate Aminotransferases; Heme Oxygenase-1; Hepatocytes; Humans; Hypoxia; Ischemia; Lact | 2023 |
PRR34-AS1 overexpression promotes protection of propofol pretreatment against ischemia/reperfusion injury in a mouse model after total knee arthroplasty via blockade of the JAK1-dependent JAK-STAT signaling pathway.
Topics: Animals; Apoptosis; Arthroplasty, Replacement, Knee; Cell Proliferation; Disease Models, Animal; Gen | 2020 |
The role of PI3K-mediated AMPA receptor changes in post-conditioning of propofol in brain protection.
Topics: Animals; Brain Ischemia; Chromones; Hippocampus; Ischemic Postconditioning; Male; Morpholines; Neuro | 2019 |
Effect of propofol on the skeletal muscle insulin receptor in rats with hepatic ischemia-reperfusion injury.
Topics: Animals; Insulin; Muscle, Skeletal; Propofol; Rats; Rats, Wistar; Receptor, Insulin; Reperfusion Inj | 2020 |
Propofol post-conditioning lessens renal ischemia/reperfusion-induced acute lung injury associated with autophagy and apoptosis through MAPK signals in rats.
Topics: Acute Kidney Injury; Acute Lung Injury; Animals; Apoptosis; Autophagy; Disease Models, Animal; Human | 2020 |
Propofol improves intestinal ischemia-reperfusion injury in rats through NF-κB pathway.
Topics: Animals; Apoptosis; Cytokines; Disease Models, Animal; Female; Hypnotics and Sedatives; Injections, | 2020 |
Ischemic Preconditioning Protects Against Hepatic Ischemia-Reperfusion Injury Under Propofol Anesthesia in Rats.
Topics: Anesthetics, Intravenous; Animals; Ischemic Preconditioning; Liver; Male; Propofol; Rats; Rats, Spra | 2020 |
Propofol protects against oxygen/glucose deprivation‑induced cell injury via gap junction inhibition in astrocytes.
Topics: Animals; Animals, Newborn; Apoptosis; Astrocytes; Cell Hypoxia; Cells, Cultured; Connexin 43; Down-R | 2020 |
Propofol Protects Against Hepatic Ischemia Reperfusion Injury via Inhibiting Bnip3-Mediated Oxidative Stress.
Topics: Animals; Apoptosis; Cell Line; Hypnotics and Sedatives; Liver; Male; Membrane Proteins; Mice; Mice, | 2021 |
Effects of propofol on cardiac function and miR-494 expression in rats with hepatic ischemia/reperfusion injury.
Topics: Animals; Apoptosis; Ischemia; Male; MicroRNAs; Propofol; Rats; Rats, Sprague-Dawley; Reperfusion Inj | 2021 |
Propofol attenuates renal ischemia/reperfusion injury by regulating the MALAT1/miR-126-5p axis.
Topics: Animals; Apoptosis; Cell Line; Gene Expression Regulation; Humans; Kidney; Kidney Tubules; Male; Mic | 2021 |
Pretreatment with Propofol Reduces Pulmonary Injury in a Pig Model of Intestinal Ischemia-Reperfusion via Suppressing the High-Mobility Group Box 1 Protein (HMGB1)/Toll-Like Receptor 4 (TLR4)/Protein Kinase R (PKR) Signaling Pathway.
Topics: Acute Lung Injury; Animals; HMGB1 Protein; Male; Propofol; Protective Agents; Reperfusion Injury; Sw | 2021 |
Propofol attenuates lung ischemia/reperfusion injury though the involvement of the MALAT1/microRNA-144/GSK3β axis.
Topics: Anesthetics, Intravenous; Animals; Autophagy; Biomarkers; Cytokines; Disease Models, Animal; Disease | 2021 |
Propofol Protects against Cerebral Ischemia/Reperfusion Injury by Down-Regulating Long Noncoding RNA SNHG14.
Topics: Animals; Apoptosis; Brain Ischemia; Glucose; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred | 2021 |
Propofol Downregulates lncRNA MALAT1 to Alleviate Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis; Brain; Disease Models, Animal; Down-Regulation; Infarction, Middle Cerebral Arte | 2021 |
Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Apoptosis; Cell Survival; Cyclosporine; | 2017 |
Nobiletin improves propofol-induced neuroprotection via regulating Akt/mTOR and TLR 4/NF-κB signaling in ischemic brain injury in rats.
Topics: Animals; Apoptosis; Behavior, Animal; Brain Ischemia; Cytokines; Flavones; Infarction, Middle Cerebr | 2017 |
TAK1 as the mediator in the protective effect of propofol on renal interstitial fibrosis induced by ischemia/reperfusion injury.
Topics: Actins; Animals; Apoptosis; Collagen Type I; Cytoprotection; Down-Regulation; Fibronectins; Fibrosis | 2017 |
Neuroprotection by Propofol Post-Conditioning: Focus on PKMζ/KCC2 Pathway Activity.
Topics: Animals; gamma-Aminobutyric Acid; Hippocampus; Interneurons; K Cl- Cotransporters; Male; Neuroprotec | 2018 |
Impact of propofol on renal ischemia/reperfusion endoplasmic reticulum stress.
Topics: Animals; Endoplasmic Reticulum Stress; Kidney; Male; Propofol; Random Allocation; Rats; Rats, Spragu | 2017 |
Effect and mechanism of propofol in hepatic ischemia/reperfusion injury of rat.
Topics: Animals; Apoptosis; Hepatocytes; In Situ Nick-End Labeling; Liver; Liver Diseases; Male; Phosphatidy | 2017 |
A Study on the Effects of the Use of Propofol in Experimental Model Inferior Epigastric Island Flap on Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Epigastric Arteries; Malondialdehyde; Propofol; Rats; Rats, Sprague-Dawley; R | 2017 |
Editorial - Propofol as an intraoperative strategy for organ protection.
Topics: Anesthetics, Intravenous; Animals; Propofol; Rats; Reperfusion Injury | 2017 |
Propofol Prevents Oxidative Stress by Decreasing the Ischemic Accumulation of Succinate in Focal Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Brain Ischemia; Ischemia; Male; Membrane Potential, Mitochondrial; Mitochondria; Neuroprote | 2018 |
Propofol attenuates myocardial ischemia reperfusion injury partly through inhibition of resident cardiac mast cell activation.
Topics: Anesthetics, Intravenous; Animals; Antioxidants; Cell Degranulation; Cell Line; Cytokines; Heart; Hi | 2018 |
Protective effect of propofol on ischemia-reperfusion injury detected by HPLC-MS/MS targeted metabolic profiling.
Topics: Anesthetics, Intravenous; Cell Hypoxia; Cell Survival; Cells, Cultured; Chromatography, High Pressur | 2018 |
Interaction between anesthetic conditioning and ischemic preconditioning on metabolic function after hepatic ischemia-reperfusion in rabbits.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Disease Models, Animal; Hemodynamics; Ischemic Precond | 2018 |
Propofol Attenuates the Myocardial Protection Properties of Desflurane by Modulating Mitochondrial Permeability Transition.
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Cardiotonic Agents; Deoxyglucose; Desflurane; Drug Ad | 2018 |
Propofol Protects Hippocampal Neurons from Hypoxia-Reoxygenation Injury by Decreasing Calcineurin-Induced Calcium Overload and Activating YAP Signaling.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Calcineurin; Calcium; Cell Line; Hippocampus; Human | 2018 |
Propofol inhibits parthanatos via ROS-ER-calcium-mitochondria signal pathway in vivo and vitro.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Brain Ischemia; Calcium; Cell Death; Cell Line; | 2018 |
The Protective Effect of Propofol Against Ischemia-Reperfusion Injury in the Interlobar Arteries: Reduction of Abnormal Cx43 Expression as a Possible Mechanism.
Topics: Animals; Blood Flow Velocity; Connexin 43; Connexins; Male; Oligopeptides; Propofol; Rats; Rats, Spr | 2018 |
Estrogen and propofol combination therapy inhibits endoplasmic reticulum stress and remarkably attenuates cerebral ischemia-reperfusion injury and OGD injury in hippocampus.
Topics: Animals; Brain Ischemia; Cell Hypoxia; Drug Therapy, Combination; Endoplasmic Reticulum Stress; Estr | 2018 |
Intravenous Anesthetic Protects Hepatocyte from Reactive Oxygen Species-Induced Cellular Apoptosis during Liver Transplantation
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Hepatocytes; Liver Transplantation; Male; Oxidative St | 2018 |
Effect of pharmacological preconditioning with sevoflurane during hepatectomy with intermittent portal triad clamping.
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Constriction; Female; Hepatectomy; Humans; | 2019 |
The role of PI3K/Akt signal pathway in the protective effects of propofol on intestinal and lung injury induced by intestinal ischemia/reperfusion1.
Topics: Anesthetics, Intravenous; Animals; Disease Models, Animal; Lung Injury; Male; Mesenteric Ischemia; P | 2019 |
Propofol can suppress renal ischemia-reperfusion injury through the activation of PI3K/AKT/mTOR signal pathway.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cytokines; Disease Models, Animal; Drug Evaluation, Preclin | 2019 |
Effect of sevoflurane-based or propofol-based anaesthesia on the incidence of postoperative acute kidney injury: A retrospective propensity score-matched analysis.
Topics: Acute Kidney Injury; Aged; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; C | 2019 |
Cox-2 Negatively Affects the Protective Role of Propofol against Hypoxia/Reoxygenation Induced Cardiomyocytes Apoptosis through Suppressing Akt Signaling.
Topics: Animals; Apoptosis; Cell Hypoxia; Cell Survival; Cyclooxygenase 2; Gene Expression Regulation; Human | 2019 |
Propofol attenuates renal ischemia-reperfusion injury aggravated by hyperglycemia.
Topics: Anesthetics, Intravenous; Animals; Antioxidants; Comorbidity; Disease Models, Animal; Etomidate; Hyp | 2013 |
Do propofol and isoflurane protect the kidney against ischemia/reperfusion injury during transient hyperglycemia?
Topics: Acute Disease; Anesthesia; Anesthetics; Animals; Cell Survival; Creatinine; Flow Cytometry; Hypergly | 2013 |
Propofol attenuates cerebral ischemia/reperfusion injury partially using heme oxygenase-1.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Biomarkers; Blotting, Western; Brain Ischemia; Heme Ox | 2013 |
Role of glycogen synthase kinase 3β in protective effect of propofol against hepatic ischemia-reperfusion injury.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 | 2013 |
The effects of propofol on mitochondrial dysfunction following focal cerebral ischemia-reperfusion in rats.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Male; Membrane Potential, Mitochondrial; Mitochondria; Neu | 2014 |
Propofol prevents lung injury after intestinal ischemia-reperfusion by inhibiting the interaction between mast cell activation and oxidative stress.
Topics: Acetophenones; Acute Lung Injury; Animals; Cell Degranulation; Enzyme-Linked Immunosorbent Assay; Hy | 2014 |
The significance and mechanism of propofol on treatment of ischemia reperfusion induced lung injury in rats.
Topics: Animals; Cytokines; Female; Lung; Lung Injury; Male; Propofol; Rats; Rats, Sprague-Dawley; Reperfusi | 2014 |
Propofol protects the immature rabbit heart against ischemia and reperfusion injury: impact on functional recovery and histopathological changes.
Topics: Animals; Cyclosporine; Heart; Hemodynamics; Lactic Acid; Myocardium; Propofol; Protective Agents; Ra | 2014 |
Sevoflurane prevents liver inflammatory response induced by lung ischemia-reperfusion.
Topics: Anesthetics, Inhalation; Animals; C-Reactive Protein; Caspase 3; Chemokine CCL2; Ferritins; Hemodyna | 2014 |
The effect of propofol on the expression of rabbit ischemia reperfusion injury-related proteins.
Topics: Animals; Female; Liver; Propofol; Proteins; Rabbits; Reperfusion Injury; Treatment Outcome | 2015 |
Propofol prevents neuronal mtDNA deletion and cerebral damage due to ischemia/reperfusion injury in rats.
Topics: Animals; Brain Ischemia; Disease Models, Animal; DNA, Mitochondrial; Hippocampus; Male; Membrane Pot | 2015 |
The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats.
Topics: Acute Disease; Animals; Brain Ischemia; CA1 Region, Hippocampal; Carboxylic Acids; Cell Survival; Di | 2015 |
Propofol post-conditioning protects the blood brain barrier by decreasing matrix metalloproteinase-9 and aquaporin-4 expression and improves the neurobehavioral outcome in a rat model of focal cerebral ischemia-reperfusion injury.
Topics: Anesthetics, Intravenous; Animals; Aquaporin 4; Blood-Brain Barrier; Brain; Brain Ischemia; MAP Kina | 2015 |
Propofol alleviates liver oxidative stress via activating Nrf2 pathway.
Topics: Anesthetics, Intravenous; Animals; Drug Evaluation, Preclinical; Intracellular Signaling Peptides an | 2015 |
Propofol ameliorates endothelial inflammation induced by hypoxia/reoxygenation in human umbilical vein endothelial cells: Role of phosphatase A2.
Topics: Anti-Inflammatory Agents; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Dose-Response Rel | 2015 |
Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation.
Topics: Acetylcysteine; Animals; Antioxidants; beta-N-Acetylhexosaminidases; Cell Degranulation; Cell Line; | 2015 |
Propofol Prevents Renal Ischemia-Reperfusion Injury via Inhibiting the Oxidative Stress Pathways.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 12; Caspase 3; Heat-Shock Proteins; Kidney; | 2015 |
The effect of propofol and sevoflurane on antioxidants and proinflammatory cytokines in a porcine ischemia-reperfusion model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Methyl Ethers; Myocytes, Sm | 2016 |
[Protective effect of propofol against cerebral ischemic/reperfusion injury may involve inhibition of gap junction].
Topics: Animals; bcl-2-Associated X Protein; Brain; Brain Ischemia; Connexin 43; Gap Junctions; Infarction, | 2015 |
The Effects of Two Anesthetics, Propofol and Sevoflurane, on Liver Ischemia/Reperfusion Injury.
Topics: Animals; bcl-2-Associated X Protein; Disease Models, Animal; Interleukin-1; Interleukin-6; Liver; Ma | 2016 |
Propofol but not sevoflurane prevents mitochondrial dysfunction and oxidative stress by limiting HIF-1α activation in hepatic ischemia/reperfusion injury.
Topics: Anesthetics; Animals; Apoptosis; Free Radicals; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor | 2016 |
Protective effects of propofol against whole cerebral ischemia/reperfusion injury in rats through the inhibition of the apoptosis-inducing factor pathway.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; bcl-2-Associated X Protein; Brain Ischemia; Hippocamp | 2016 |
Sevoflurane anesthetic preconditioning protects the lung endothelial glycocalyx from ischemia reperfusion injury in an experimental lung autotransplant model.
Topics: Anesthetics; Animals; Glycocalyx; Intercellular Adhesion Molecule-1; Lung; Methyl Ethers; One-Lung V | 2016 |
The Effect of Propofol on Mitochondrial Fission during Oxygen-Glucose Deprivation and Reperfusion Injury in Rat Hippocampal Neurons.
Topics: Animals; Calcium; Cell Survival; Cells, Cultured; Glucose; Hippocampus; Hypoxia; Mitochondria; Mitoc | 2016 |
Propofol postconditioning attenuates hippocampus ischemia-reperfusion injury via modulating JAK2/STAT3 pathway in rats after autogenous orthotropic liver transplantation.
Topics: Animals; Apoptosis; Brain Ischemia; Hippocampus; Janus Kinase 2; Liver Transplantation; Male; Neurop | 2017 |
Propofol protects against hepatic ischemia/reperfusion injury via miR-133a-5p regulating the expression of MAPK6.
Topics: Animals; Apoptosis; Base Sequence; Cell Line; Gene Expression Regulation; Hepatocytes; Humans; Liver | 2017 |
The effects of Y-27632 on pial microvessels during global brain ischemia and reperfusion in rabbits.
Topics: Amides; Animals; Blood Glucose; Blood Pressure; Brain Ischemia; Microvessels; Pia Mater; Propofol; P | 2017 |
[Comparison of propofol concentration in the spinal cord between intra-aortic and intravenous infusion].
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Heart Rate; Infusions, Intravenous; Injecti | 2008 |
[Propofol ameliorates rat liver ischemia-reperfusion injury possibly by inhibiting nuclear factor-kappaB expression].
Topics: Animals; Blotting, Western; Down-Regulation; Liver; Male; NF-kappa B; Propofol; Random Allocation; R | 2008 |
[Protective effects of propofol combined with reserpine on cultured PC12 cells impaired by ischemia and reperfusion].
Topics: Animals; Calcium; Cell Hypoxia; L-Lactate Dehydrogenase; PC12 Cells; Propofol; Rats; Reperfusion Inj | 2008 |
Propofol attenuates the decrease of dynamic compliance and water content in the lung by decreasing oxidative radicals released from the reperfused liver.
Topics: Alanine Transaminase; Anesthesia; Anesthetics, Intravenous; Animals; Hypnotics and Sedatives; Lipid | 2008 |
[A comparison of protective effect of propofol and edaravone pretreatment against cerebral ischemia-reperfusion injury].
Topics: Animals; Antipyrine; Apoptosis; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Cortex; Eda | 2008 |
Propofol pretreatment reduces ceramide production and attenuates intestinal mucosal apoptosis induced by intestinal ischemia/reperfusion in rats.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Ceramides; Intestinal Mucosa; Male; Malondialdehyde; M | 2008 |
Propofol pretreatment attenuates aquaporin-4 over-expression and alleviates cerebral edema after transient focal brain ischemia reperfusion in rats.
Topics: Anesthetics, Intravenous; Animals; Aquaporin 4; Brain Edema; Ischemic Attack, Transient; Male; Propo | 2008 |
Effects of propofol on the mRNA expression of toll-like receptor 4 in BV-2 cells during mimic ischemia-reperfusion injury in vitro.
Topics: Animals; Brain Ischemia; Cell Line; Mice; Microglia; Neuroprotective Agents; NF-kappa B; Propofol; R | 2008 |
[Effect of propofol on spinal excitatory amino acid accumulation].
Topics: Animals; Excitatory Amino Acids; Female; Male; Propofol; Rabbits; Reperfusion Injury; Spinal Cord; S | 2009 |
The comparison of the effects of anesthetic doses of ketamine, propofol, and etomidate on ischemia-reperfusion injury in skeletal muscle.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Disease Models, Animal; Etomidate; Fem | 2010 |
Propofol protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via Akt activation and Bcl-2 up-regulation.
Topics: Androstadienes; Anesthetics, Intravenous; Animals; Antioxidants; Apoptosis; Cardiotonic Agents; Coro | 2009 |
The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats.
Topics: Androstadienes; Animals; Brain; Brain Infarction; Disease Models, Animal; Dose-Response Relationship | 2009 |
[Protective effect of hypothermic propofol on ischemic spinal cords].
Topics: Animals; Aorta; Female; Hypothermia, Induced; Injections, Intra-Arterial; Male; Neuroprotective Agen | 2009 |
The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion.
Topics: Adenosine Triphosphate; Animals; Antimycin A; Apoptosis; Cell Survival; Cytoprotection; Decanoic Aci | 2009 |
Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation.
Topics: Animals; Animals, Newborn; Aquaporin 4; Astrocytes; Brain Diseases; Brain Edema; Cell Hypoxia; Cell | 2009 |
Ischemia-reperfusion injury in skeletal muscle: comparison of the effects of subanesthetic doses of ketamine, propofol, and etomidate.
Topics: Anesthetics; Animals; Catalase; Etomidate; Female; Glutathione Peroxidase; Ketamine; Malondialdehyde | 2010 |
Cerebral pial vascular changes under propofol or sevoflurane anesthesia during global cerebral ischemia and reperfusion in rabbits.
Topics: Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Arterioles; Blo | 2010 |
Thiopental improves renal ischemia-reperfusion injury.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Antioxidants; Catalase; Etomidate; Fat | 2010 |
Protective effects of propofol against ischemia/reperfusion injury in rat kidneys.
Topics: Anesthetics, Intravenous; Animals; Catalase; Kidney; Malondialdehyde; Propofol; Rats; Rats, Wistar; | 2010 |
The effects of propofol on hippocampal caspase-3 and Bcl-2 expression following forebrain ischemia-reperfusion in rats.
Topics: Anesthetics, Intravenous; Animals; Caspase 3; Disease Models, Animal; Hippocampus; Hypoxia-Ischemia, | 2010 |
Volatile anesthetics might be more beneficial than propofol for postoperative liver function in cirrhotic patients receiving hepatectomy.
Topics: Anesthetics, Inhalation; Desflurane; Heme Oxygenase (Decyclizing); Hepatectomy; Humans; Hypoxia-Indu | 2010 |
Propofol protects the autophagic cell death induced by the ischemia/reperfusion injury in rats.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Down-Regulation; Male; Microtubule-Asso | 2010 |
Propofol prevents lung injury following intestinal ischemia-reperfusion.
Topics: Acute Lung Injury; Anesthetics, Intravenous; Animals; Antioxidants; Bronchoalveolar Lavage; Intestin | 2012 |
[The effect of propofol preconditioning on cytochrome C release from mitochondria after mild hypothermic ischemia/reperfusion in isolated rat hearts].
Topics: Animals; Apoptosis; Cytochromes c; Hypothermia, Induced; In Vitro Techniques; Ischemic Preconditioni | 2009 |
[Effect of propofol on anti-oxidation capability in the ischemia/reperfusion injury after hepatic ischemia in rabbits].
Topics: Alanine Transaminase; Animals; Free Radical Scavengers; Liver; Malondialdehyde; Oxidation-Reduction; | 2005 |
[Effect of propofol on iNOS expression in hippocampus after global cerebral ischemia/reperfusion injury of rats].
Topics: Animals; Brain Ischemia; Hippocampus; Male; Nitric Oxide Synthase Type II; Propofol; Rats; Rats, Wis | 2007 |
[Effect of propofol on glutamate, ascorbic acid release in hippocampus during global cerebral ischemia/reperfusion in rats].
Topics: Animals; Ascorbic Acid; Brain Ischemia; Glutamic Acid; Hippocampus; Male; Propofol; Rats; Rats, Wist | 2006 |
[The effect of propofol on astrocyte GFAP expression after the focal cerebral ischemia].
Topics: Animals; Astrocytes; Brain Ischemia; Glial Fibrillary Acidic Protein; Neuroprotective Agents; Propof | 2009 |
Enhanced glucose uptake via GLUT4 fuels recovery from calcium overload after ischaemia-reperfusion injury in sevoflurane- but not propofol-treated hearts.
Topics: AMP-Activated Protein Kinase Kinases; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Bl | 2011 |
[Protective effect of fospropofol disodium on in vivo liver ischemia-reperfusion injury in rats].
Topics: Animals; Antioxidants; Female; Liver; Male; Propofol; Protective Agents; Random Allocation; Rats; Ra | 2011 |
Does propofol prevent testicular ischemia-reperfusion injury due to torsion in the long term?
Topics: Anesthetics, Intravenous; Animals; Male; Propofol; Rats; Rats, Sprague-Dawley; Reperfusion Injury; S | 2011 |
Addition of a water-soluble propofol formulation to preservation solution in experimental kidney transplantation.
Topics: Alkanes; Anesthetics, Intravenous; Animals; Antioxidants; Cells, Cultured; Chemistry, Pharmaceutical | 2011 |
Propofol improved neurobehavioral outcome of cerebral ischemia-reperfusion rats by regulating Bcl-2 and Bax expression.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Brain Is | 2011 |
Propofol post-conditioning induced long-term neuroprotection and reduced internalization of AMPAR GluR2 subunit in a rat model of focal cerebral ischemia/reperfusion.
Topics: Anesthetics, Intravenous; Animals; Antimetabolites; Behavior, Animal; Blotting, Western; Brain Ische | 2011 |
Alternative use of isoflurane and propofol confers superior cardioprotection than using one of them alone in a dog model of cardiopulmonary bypass.
Topics: Animals; Cardiopulmonary Bypass; Cardiotonic Agents; Dogs; Drug Interactions; Heart; Hemodynamics; I | 2012 |
Antioxidant effects of propofol on tourniquet-induced ischemia-reperfusion injury: an experimental study.
Topics: Anesthetics, Intravenous; Animals; Antioxidants; Catalase; Disease Models, Animal; Femoral Artery; G | 2012 |
Propofol effects on the morphology of rat testes subjected to testicular ischemia-reperfusion.
Topics: Anesthetics, Intravenous; Animals; Male; Orchiectomy; Propofol; Rats; Rats, Wistar; Reperfusion Inju | 2012 |
Propofol attenuates hepatic ischemia/reperfusion injury in an in vivo rabbit model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hemodynamics; Liver; Male; Propof | 2012 |
Propofol prevents autophagic cell death following oxygen and glucose deprivation in PC12 cells and cerebral ischemia-reperfusion injury in rats.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Survival; Cerebral Cortex; Class I | 2012 |
Neuroprotective effects of propofol, thiopental, etomidate, and midazolam in fetal rat brain in ischemia-reperfusion model.
Topics: Animals; Disease Models, Animal; Embryo, Mammalian; Etomidate; Female; Lipid Peroxidation; Male; Mic | 2012 |
Ischemia-reperfusion-induced unmeasured anion generation and glycocalyx shedding: sevoflurane versus propofol anesthesia.
Topics: Acid-Base Equilibrium; Anesthetics; Animals; Capillary Permeability; Disease Models, Animal; Endothe | 2012 |
[Neuroprotective effects of combined pretreatment with edaravone and propofol on neonatal rat cerebral cortical neurons with ischemia/reperfusion injury in vitro].
Topics: Animals; Antipyrine; Apoptosis; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Cortex; Eda | 2012 |
Breath pentane as a potential biomarker for survival in hepatic ischemia and reperfusion injury--a pilot study.
Topics: Anesthetics, Intravenous; Animals; Aspartate Aminotransferases; Biomarkers; Disease Models, Animal; | 2012 |
Does pharmacological conditioning with the volatile anaesthetic sevoflurane offer protection in liver surgery?
Topics: Administration, Inhalation; Adult; Aged; Alanine Transaminase; Anesthetics, Inhalation; Anesthetics, | 2012 |
Propofol increases expression of basic fibroblast growth factor after transient cerebral ischemia in rats.
Topics: Animals; Fibroblast Growth Factor 2; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; | 2013 |
[Effects of propofol on PI3K/Akt signaling pathway and endoplasmic reticulum stress pathway of apoptosis induced by ischemia-reperfusion in isolated rat hearts].
Topics: Animals; Apoptosis; Endoplasmic Reticulum Stress; Heart; In Vitro Techniques; Male; Phosphatidylinos | 2012 |
[Protective effect of propofol and resveratrol pretreatment against hepatocyte apoptosis in rats with hepatic ischemia-reperfusion injury].
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Hepatocytes; Ischemic Preconditioning; Li | 2013 |
[Effect of propofol on protecting Rhesus macaques from reperfusion lung injury during hemorrhagic shock and resuscitation].
Topics: Animals; Anticonvulsants; Lactates; Lung; Lung Diseases; Macaca mulatta; Male; Malondialdehyde; Prop | 2002 |
Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Edema; Brain Ischemia; Excitatory Amino Acids; Male; M | 2003 |
Propofol displays no protective effect against hypoxia/reoxygenation injury in rat liver slices.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Alanine Transaminase; Anesthetics, Intravenous; Animals | 2003 |
Propofol decreases reperfusion-induced arrhythmias in a model of "border zone" between normal and ischemic-reperfused guinea pig myocardium.
Topics: Action Potentials; Anesthetics, Intravenous; Animals; Arrhythmias, Cardiac; Electrodes, Implanted; E | 2003 |
Antioxidant effect of gamma-tocopherol supplied by propofol preparations (Diprivan) during ischemia-reperfusion in experimental lung transplantation.
Topics: Analysis of Variance; Animals; Antioxidants; gamma-Tocopherol; Lung Transplantation; Models, Animal; | 2004 |
Electrocerebral silence by intracarotid anesthetics does not affect early hyperemia after transient cerebral ischemia in rabbits.
Topics: Anesthetics, Intravenous; Animals; Brain; Carotid Artery, Internal; Cerebrovascular Circulation; Ele | 2004 |
Propofol attenuates reperfusion injury after testicular torsion and detorsion.
Topics: Animals; Free Radical Scavengers; Male; Propofol; Rats; Reperfusion Injury; Spermatic Cord Torsion | 2004 |
[Propofol reduces intercellular adhesion molecular-1 expression in lung injury following intestinal ischemia/reperfusion in rats].
Topics: Animals; Disease Models, Animal; Female; Intercellular Adhesion Molecule-1; Intestines; Lung Injury; | 2005 |
[Effect of propofol on the activation of nuclear factor-kappa B and expression of inflammatory cytokines in cerebral cortex during transient focal cerebral ischemia-reperfusion: experiment with rats].
Topics: Animals; Intercellular Adhesion Molecule-1; Interleukin-1; Ischemic Attack, Transient; Male; NF-kapp | 2004 |
Propofol attenuates lung endothelial injury induced by ischemia-reperfusion and oxidative stress.
Topics: Anesthetics, Intravenous; Animals; CHO Cells; Cricetinae; Endothelium; Enzyme-Linked Immunosorbent A | 2005 |
Propofol is cardioprotective in a clinically relevant model of normothermic blood cardioplegic arrest and cardiopulmonary bypass.
Topics: Anesthetics, Intravenous; Animals; Body Temperature; Cardioplegic Solutions; Cardiopulmonary Bypass; | 2005 |
Comparison of propofol with lidocaine pretreatment versus propofol formulated with long- and medium-chain triglycerides or confounding effect of tourniquet.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Chemistry, Pharmaceutical; Excipients; Humans; Injecti | 2005 |
The influence of propofol on P-selectin expression and nitric oxide production in re-oxygenated human umbilical vein endothelial cells.
Topics: Antioxidants; Cell Hypoxia; Cells, Cultured; Endothelial Cells; Humans; Nitric Oxide; Nitric Oxide S | 2006 |
Does propofol or caffeic acid phenethyl ester prevent lung injury after hindlimb ischaemia-reperfusion in ventilated rats?
Topics: Animals; Caffeic Acids; Free Radical Scavengers; Hindlimb; Ischemia; Lung; Lung Diseases; Male; Malo | 2006 |
The preventive effects of thiopental and propofol on testicular ischemia-reperfusion injury.
Topics: Anesthetics, Intravenous; Animals; Male; Malondialdehyde; Nitric Oxide; Propofol; Rats; Rats, Wistar | 2006 |
Effects of sevoflurane and propofol on ischaemia-reperfusion injury after thoracic-aortic occlusion in pigs.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Aortic Aneurysm, Thoracic; Blood Pressur | 2007 |
Propofol attenuates intestinal mucosa injury induced by intestinal ischemia-reperfusion in the rat.
Topics: Animals; Endothelin-1; Free Radical Scavengers; Intestinal Mucosa; Intestine, Small; Lactic Acid; Ma | 2007 |
Propofol attenuation of renal ischemia/reperfusion injury involves heme oxygenase-1.
Topics: Animals; Blood Urea Nitrogen; Blotting, Western; Creatinine; Heme Oxygenase (Decyclizing); Immunohis | 2007 |
Propofol attenuates ischaemia-reperfusion injury in the rat heart in vivo.
Topics: Anesthetics, Intravenous; Animals; Antioxidants; Blood Pressure; Cardiotonic Agents; Disease Models, | 2008 |
The effects of propofol on cardiac function after 4 hours of cold cardioplegia and reperfusion.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Bradykinin; Coronary Vessels; Glucose; Heart; Heart Ar | 2007 |
Propofol reduces nitric oxide-induced apoptosis in testicular ischemia-reperfusion injury by downregulating the expression of inducible nitric oxide synthase.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; Biomarkers; Im | 2008 |
Effects of propofol on early phase of warm hepatic ischemia/reperfusion injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Lipid Peroxidation; Liver; Male; Malondi | 2007 |
Effect of propofol on pathologic time-course and apoptosis after cerebral ischemia-reperfusion injury.
Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Edema; Male; Neurons; Propofol; Proto-On | 2008 |
[Effect of propofol on gastric mucosal injury after hemorrhagic shock and reperfusion in rabbits].
Topics: Animals; Disease Models, Animal; Gastric Mucosa; Male; Malondialdehyde; Propofol; Rabbits; Random Al | 2008 |
Anesthetics and natural heme oxygenase-1 inducers: waiting for carbon monoxide?
Topics: Anesthetics; Animals; Anthocyanins; Antioxidants; Carbon Monoxide; Curcumin; Cytoprotection; Disease | 2008 |
[Effect of propofol aortic infusion on ischemia-reperfusion spinal cords of rabbits].
Topics: Anesthetics, Intravenous; Animals; Interleukin-6; Motor Activity; Neuroprotective Agents; Paraplegia | 2008 |
Lung injury following thoracic aortic occlusion: comparison of sevoflurane and propofol anaesthesia.
Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Aorta, Thoracic; Arterial Oc | 2008 |
Comparison of the effects of propofol and halothane on acute myocardial ischaemia and myocardial reperfusion injury.
Topics: Anesthetics, Inhalation; Animals; Free Radical Scavengers; Halothane; Myocardial Ischemia; Propofol; | 1996 |
Propofol neuroprotection in a rat model of ischaemia reperfusion injury.
Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Antioxidants; Brain; Brain I | 1997 |
Propofol improves functional and metabolic recovery in ischemic reperfused isolated rat hearts.
Topics: Adenine Nucleotides; Animals; Blood Pressure; Coronary Circulation; Energy Metabolism; Heart Rate; L | 1998 |
Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Baclofen; Brain Ischemia; Dose-Response Relationship, Drug; GABA | 1999 |
[Effects of endothelin antagonists on isolated perfused murine livers in the early phase of warm ischemia-reperfusion injury under propofol anesthesia].
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Azepines; Bosentan; Disease Models, Anim | 1999 |
A new porcine model of reperfusion injury after lung transplantation.
Topics: Animals; Azaperone; Disease Models, Animal; Female; Hypnotics and Sedatives; Lung Transplantation; P | 1999 |
Recovery from myocardial stunning is faster with desflurane compared with propofol in chronically instrumented dogs.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Pressure; Desflurane; Dogs; Female | 2000 |
Effectiveness of propofol pretreatment on the extent of deranged cerebral mitochondrial oxidative enzyme system after incomplete forebrain ischemia/reperfusion in rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Free Radical Scavengers; Mitoc | 2000 |
Neuroprotective effects of propofol following global cerebral ischemia in rats.
Topics: Anesthetics, Intravenous; Animals; Brain Ischemia; Lipid Peroxides; Male; Malondialdehyde; Neuroprot | 2002 |