propofol has been researched along with Inadequate Sleep in 13 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated changes in social and anxiety-related brain functional connectivity induced by sleep deprivation, and the potential therapeutic effects of the general anaesthetics propofol and sevoflurane in rats." | 8.31 | Effects of propofol and sevoflurane on social and anxiety-related behaviours in sleep-deprived rats. ( Chen, C; Chen, T; Fang, Y; He, M; Li, S; Ma, D; Manyande, A; Sadigh-Eteghad, S; Wang, J; Wu, J; Xu, F; Xu, H; Zhang, Z; Zheng, F; Zhou, Y; Zhu, J, 2023) |
| " The rats received propofol anesthesia (75 mg/kg, i." | 8.12 | Effects of dopamine transporter in the ventral tegmental area on sleep recovery after propofol anesthesia in sleep-deprived rats. ( Du, T; Jia, L; Li, Y; Ma, K; Qin, X; Yin, J; Zhang, H, 2022) |
| " We investigated changes in social and anxiety-related brain functional connectivity induced by sleep deprivation, and the potential therapeutic effects of the general anaesthetics propofol and sevoflurane in rats." | 4.31 | Effects of propofol and sevoflurane on social and anxiety-related behaviours in sleep-deprived rats. ( Chen, C; Chen, T; Fang, Y; He, M; Li, S; Ma, D; Manyande, A; Sadigh-Eteghad, S; Wang, J; Wu, J; Xu, F; Xu, H; Zhang, Z; Zheng, F; Zhou, Y; Zhu, J, 2023) |
| " The rats received propofol anesthesia (75 mg/kg, i." | 4.12 | Effects of dopamine transporter in the ventral tegmental area on sleep recovery after propofol anesthesia in sleep-deprived rats. ( Du, T; Jia, L; Li, Y; Ma, K; Qin, X; Yin, J; Zhang, H, 2022) |
| "Propofol has been shown to clear sleep debt in rats after sleep deprivation (SD)." | 1.91 | Propofol-induced sleep ameliorates cognition impairment in sleep-deprived rats. ( Dai, W; Lu, Y; Tu, Y; Xiao, Y; Xie, Y, 2023) |
| "However, it is unknown whether sleep deprivation affects the potency of inhaled anesthetics." | 1.72 | Sleep Deprivation Increases the Anesthetic Potency of Sevoflurane Regardless of Duration. ( Cui, N; Qian, H; Zhang, S; Zhou, Q, 2022) |
| "Oral propofol treatment causes anesthesia in flies as indicated by a dose-dependent reduction in locomotor activity (n = 11 to 41 flies from each group) and increased arousal threshold (n = 79 to 137)." | 1.43 | Sleep Homeostasis and General Anesthesia: Are Fruit Flies Well Rested after Emergence from Propofol? ( Coradetti, T; Gardner, B; Kelz, MB; Meng, QC; Naidoo, NN; Strus, E; Williams, JA, 2016) |
| "Moreover, preexisting sleep debts dissipate during propofol anesthesia." | 1.37 | Rapid eye movement sleep debt accrues in mice exposed to volatile anesthetics. ( Chen, Y; Friedman, EB; Kelz, MB; Moore, JT; Pick, J; Sun, Y; Wyner, AJ, 2011) |
| "Recovery from sleep deprivation in anesthetized rats was similar in timing to that of controls." | 1.32 | Recovery from sleep deprivation occurs during propofol anesthesia. ( Bergmann, BM; Cao, D; Herrera, S; Mendelson, WB; Tung, A, 2004) |
| "Sleep deprivation was produced by placing rats on a disk that rotated when sleep was detected by electroencephalographic and electromyographic (EEG, EMG) monitoring." | 1.31 | Sleep deprivation potentiates the onset and duration of loss of righting reflex induced by propofol and isoflurane. ( Bluhm, B; Mendelson, WB; Szafran, MJ; Tung, A, 2002) |
| "Upon emergence, no evidence of sleep deprivation was observed." | 1.31 | Prolonged sedation with propofol in the rat does not result in sleep deprivation. ( Lynch, JP; Mendelson, WB; Tung, A, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 6 (46.15) | 2.80 |
| Authors | Studies |
|---|---|
| Shen, M | 1 |
| Lian, N | 1 |
| Song, C | 1 |
| Qin, C | 1 |
| Yu, Y | 2 |
| Lu, Y | 1 |
| Xiao, Y | 1 |
| Tu, Y | 1 |
| Dai, W | 1 |
| Xie, Y | 1 |
| Qian, H | 1 |
| Zhou, Q | 1 |
| Cui, N | 1 |
| Zhang, S | 1 |
| Zhang, H | 1 |
| Yin, J | 2 |
| Jia, L | 1 |
| Qin, X | 1 |
| Du, T | 1 |
| Ma, K | 1 |
| Li, Y | 1 |
| Zhu, J | 1 |
| Chen, C | 1 |
| Wu, J | 1 |
| He, M | 1 |
| Li, S | 1 |
| Fang, Y | 1 |
| Zhou, Y | 1 |
| Xu, H | 1 |
| Sadigh-Eteghad, S | 1 |
| Manyande, A | 1 |
| Zheng, F | 1 |
| Chen, T | 1 |
| Xu, F | 1 |
| Ma, D | 1 |
| Wang, J | 1 |
| Zhang, Z | 1 |
| Scheinin, A | 1 |
| Kantonen, O | 1 |
| Alkire, M | 1 |
| Långsjö, J | 1 |
| Kallionpää, RE | 1 |
| Kaisti, K | 1 |
| Radek, L | 1 |
| Johansson, J | 1 |
| Sandman, N | 1 |
| Nyman, M | 1 |
| Scheinin, M | 1 |
| Vahlberg, T | 1 |
| Revonsuo, A | 1 |
| Valli, K | 1 |
| Scheinin, H | 1 |
| Vanini, G | 1 |
| Nemanis, K | 1 |
| Baghdoyan, HA | 1 |
| Lydic, R | 1 |
| Gardner, B | 1 |
| Strus, E | 1 |
| Meng, QC | 1 |
| Coradetti, T | 1 |
| Naidoo, NN | 1 |
| Kelz, MB | 2 |
| Williams, JA | 1 |
| Xie, F | 1 |
| Li, X | 1 |
| Bao, M | 1 |
| Shi, R | 1 |
| Yue, Y | 1 |
| Guan, Y | 1 |
| Wang, Y | 1 |
| Pick, J | 1 |
| Chen, Y | 1 |
| Moore, JT | 1 |
| Sun, Y | 1 |
| Wyner, AJ | 1 |
| Friedman, EB | 1 |
| Tung, A | 3 |
| Szafran, MJ | 1 |
| Bluhm, B | 1 |
| Mendelson, WB | 3 |
| Bergmann, BM | 1 |
| Herrera, S | 1 |
| Cao, D | 1 |
| Lynch, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open Label, Pilot Study Utilizing an IV Infusion of Propofol in Male and Female Volunteers With Refractory Chronic Primary Insomnia[NCT02043977] | Phase 1 | 2 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 other studies available for propofol and Inadequate Sleep
| Article | Year |
|---|---|
Different Anesthetic Drugs Mediate Changes in Neuroplasticity During Cognitive Impairment in Sleep-Deprived Rats via Different Factors.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Cognitive Dysfunction; Disease Models, A | 2021 |
Propofol-induced sleep ameliorates cognition impairment in sleep-deprived rats.
Topics: Adenosine Triphosphate; Animals; bcl-2-Associated X Protein; Caspase 3; Cognition; Propofol; Rats; S | 2023 |
Sleep Deprivation Increases the Anesthetic Potency of Sevoflurane Regardless of Duration.
Topics: Anesthetics, Inhalation; Animals; Isoflurane; Mice; Propofol; Sevoflurane; Sleep Deprivation | 2022 |
Effects of dopamine transporter in the ventral tegmental area on sleep recovery after propofol anesthesia in sleep-deprived rats.
Topics: Anesthesia; Animals; Dopamine Plasma Membrane Transport Proteins; Male; Propofol; Rats; Rats, Spragu | 2022 |
Effects of propofol and sevoflurane on social and anxiety-related behaviours in sleep-deprived rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Anxiety; Male; Methyl Ethers; Propofol; | 2023 |
Foundations of Human Consciousness: Imaging the Twilight Zone.
Topics: Adult; Brain; Consciousness; Dexmedetomidine; Humans; Hypnotics and Sedatives; Male; Positron-Emissi | 2021 |
GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.
Topics: 3-Mercaptopropionic Acid; Anesthetics, General; Animals; Consciousness; GABA Agents; GABA Uptake Inh | 2014 |
Sleep Homeostasis and General Anesthesia: Are Fruit Flies Well Rested after Emergence from Propofol?
Topics: Analysis of Variance; Anesthesia Recovery Period; Anesthesia, General; Animals; Chromatography, High | 2016 |
Anesthetic propofol normalized the increased release of glutamate and γ-amino butyric acid in hippocampus after paradoxical sleep deprivation in rats.
Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Hypnotics and Sedatives; Male; Microdi | 2015 |
Rapid eye movement sleep debt accrues in mice exposed to volatile anesthetics.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Electrodes, Impl | 2011 |
Sleep deprivation potentiates the onset and duration of loss of righting reflex induced by propofol and isoflurane.
Topics: Administration, Inhalation; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Infusions, I | 2002 |
Recovery from sleep deprivation occurs during propofol anesthesia.
Topics: Anesthesia Recovery Period; Anesthesia, Intravenous; Animals; Male; Propofol; Rats; Rats, Sprague-Da | 2004 |
Prolonged sedation with propofol in the rat does not result in sleep deprivation.
Topics: Animals; Behavior, Animal; Conscious Sedation; Electroencephalography; Hypnotics and Sedatives; Male | 2001 |