propofol has been researched along with Hypothermia, Accidental in 24 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dogs in which anesthesia was induced with a benzodiazepine plus propofol or ketamine became hypothermic; the extent of hypothermia was more profound for the propofol combination." | 9.22 | Effects of anesthetic induction with a benzodiazepine plus ketamine hydrochloride or propofol on hypothermia in dogs undergoing ovariohysterectomy. ( Bornkamp, JL; DiGangi, BA; Harrison, K; Isaza, NM; Pablo, L; Robertson, S, 2016) |
| " propofol were consistently lower than those in patients who received inhaled sevoflurane, although anesthesia was subsequently maintained with sevoflurane in nitrous oxide in both groups." | 9.09 | Less core hypothermia when anesthesia is induced with inhaled sevoflurane than with intravenous propofol. ( Ikeda, K; Ikeda, T; Kazama, T; Kikura, M; Sato, S; Sessler, DI, 1999) |
| "Core hypothermia during the first hour of anesthesia was less after induction of anesthesia with ketamine than propofol." | 9.09 | Induction of anesthesia with ketamine reduces the magnitude of redistribution hypothermia. ( Ikeda, T; Kazama, T; Niwa, K; Sato, S; Sessler, DI; Shimada, C; Toriyama, S, 2001) |
| " This study investigated the incidence of hypothermia and changes in the body temperature in patients undergoing arthroscopic shoulder surgery under ISBPB with propofol sedation." | 8.02 | The effect of interscalene brachial plexus block with propofol sedation on preventing perioperative hypothermia during arthroscopic shoulder surgery. ( Baek, SM; Heo, HJ; Jung, DW; Kim, KM; Kim, YY; Lee, JH, 2021) |
| "We previously found that propofol attenuated the mortality rate and inflammatory responses during endotoxemia in rats; however, whether propofol retains its antiinflammatory effects during hypothermia has not been determined." | 7.74 | The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia. ( Kanakura, H; Taniguchi, T, 2007) |
| "Mild hypothermia is a common complication during spinal anesthesia and may induce a serious adverse outcome." | 6.71 | Effect of low-dose ketamine on redistribution hypothermia during spinal anesthesia sedated by propofol. ( Kinoshita, T; Ogawa, R; Shimada, Y; Suzuki, M, 2004) |
| "Ketamine was used in 63/79 patients (80%)." | 5.56 | Secondary hypothermia in patients with super-refractory status epilepticus managed with propofol and ketamine. ( Ciccotto, G; Iwuchukwu, IO; Khan, F; Khandker, N; McGrade, H; Menon, U; Poongkunran, M; Ramsay, E; Sabharwal, V; Talahma, M, 2020) |
| "In this effectiveness trial, inhalation inductions with sevoflurane or with prophylactic phenylephrine bolus prior to propofol induction reduced the magnitude of redistribution hypothermia by an average of 0." | 5.30 | Induction techniques that reduce redistribution hypothermia: a prospective, randomized, controlled, single blind effectiveness study. ( Braitman, LE; Hunt, LH; Roth, JV, 2019) |
| "Dogs in which anesthesia was induced with a benzodiazepine plus propofol or ketamine became hypothermic; the extent of hypothermia was more profound for the propofol combination." | 5.22 | Effects of anesthetic induction with a benzodiazepine plus ketamine hydrochloride or propofol on hypothermia in dogs undergoing ovariohysterectomy. ( Bornkamp, JL; DiGangi, BA; Harrison, K; Isaza, NM; Pablo, L; Robertson, S, 2016) |
| " propofol were consistently lower than those in patients who received inhaled sevoflurane, although anesthesia was subsequently maintained with sevoflurane in nitrous oxide in both groups." | 5.09 | Less core hypothermia when anesthesia is induced with inhaled sevoflurane than with intravenous propofol. ( Ikeda, K; Ikeda, T; Kazama, T; Kikura, M; Sato, S; Sessler, DI, 1999) |
| "Core hypothermia during the first hour of anesthesia was less after induction of anesthesia with ketamine than propofol." | 5.09 | Induction of anesthesia with ketamine reduces the magnitude of redistribution hypothermia. ( Ikeda, T; Kazama, T; Niwa, K; Sato, S; Sessler, DI; Shimada, C; Toriyama, S, 2001) |
| "The risk factors for delayed neurocognitive recovery in elderly patients undergoing thoracic surgery include diabetes, perioperative inadvertent hypothermia (< 35℃), VICA (sevoflurane combined with propofol anesthesia), and history of cerebrovascular events." | 4.31 | Risk factors for delayed neurocognitive recovery in elderly patients undergoing thoracic surgery. ( Chen, B; Kang, W; Liu, T; Liu, W; Luo, T; Wang, L, 2023) |
| "Sedation with propofol or dexmedetomidine starting at return of spontaneous circulation improved survival in hypothermia-treated mice (propofol [13 of 16, 81%] vs." | 4.12 | Post-cardiac arrest Sedation Promotes Electroencephalographic Slow-wave Activity and Improves Survival in a Mouse Model of Cardiac Arrest. ( Amorim, E; Ichinose, F; Ikeda, T; Kato, R; Malhotra, R; Marutani, E; Miyazaki, Y; Silverman, MG; Solt, K, 2022) |
| " This study investigated the incidence of hypothermia and changes in the body temperature in patients undergoing arthroscopic shoulder surgery under ISBPB with propofol sedation." | 4.02 | The effect of interscalene brachial plexus block with propofol sedation on preventing perioperative hypothermia during arthroscopic shoulder surgery. ( Baek, SM; Heo, HJ; Jung, DW; Kim, KM; Kim, YY; Lee, JH, 2021) |
| "We previously found that propofol attenuated the mortality rate and inflammatory responses during endotoxemia in rats; however, whether propofol retains its antiinflammatory effects during hypothermia has not been determined." | 3.74 | The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia. ( Kanakura, H; Taniguchi, T, 2007) |
| "8% used inhalants (particularly isoflurane) for anesthesia, and ketamine, propofol, and butorphanol were the most commonly used injectable agents." | 3.72 | Evaluation of the use of anesthesia and analgesia in reptiles. ( Read, MR, 2004) |
| "Hypotension was defined as systolic blood pressure (SBP) < 90 mmHg, MAP < 60 mmHg, or a reduction in either SBP or MAP > 20% from baseline values." | 2.82 | Prewarming neurosurgical patients to minimize hypotension on induction of anesthesia: a randomized trial. ( Darvall, J; Leslie, K; Vijayakumar, R, 2016) |
| "Mild hypothermia is a common complication during spinal anesthesia and may induce a serious adverse outcome." | 2.71 | Effect of low-dose ketamine on redistribution hypothermia during spinal anesthesia sedated by propofol. ( Kinoshita, T; Ogawa, R; Shimada, Y; Suzuki, M, 2004) |
| "Propofol anesthesia has more thermogenic effect than isoflurane when combined with amino acid solutions." | 2.70 | Effect of amino acid solutions on intraoperative hypothermia and postoperative shivering. Comparison of two anesthetic regimens. ( Aypar, U; Sahin, A, 2002) |
| "Ketamine was used in 63/79 patients (80%)." | 1.56 | Secondary hypothermia in patients with super-refractory status epilepticus managed with propofol and ketamine. ( Ciccotto, G; Iwuchukwu, IO; Khan, F; Khandker, N; McGrade, H; Menon, U; Poongkunran, M; Ramsay, E; Sabharwal, V; Talahma, M, 2020) |
| "Treatment with propofol during organ preservation did not reduce neutrophil infiltration into the graft." | 1.37 | Addition of a water-soluble propofol formulation to preservation solution in experimental kidney transplantation. ( Buurman, WA; de Vries, EE; Haenen, GR; Parkkinen, J; Peutz-Kootstra, CJ; Schurink, GW; Snoeijs, MG; Vaahtera, L; van Heurn, LW, 2011) |
| "Where hypotension was present, the method of and response to treatment was recorded." | 1.36 | A comparison of anesthetic complications between diabetic and nondiabetic dogs undergoing phacoemulsification cataract surgery: a retrospective study. ( Clark, L; Corletto, F; Gould, DJ; Oliver, JA, 2010) |
| "Hypothermia is a common complication of general anaesthesia and surgery." | 1.34 | Effect of hypothermia on recovery from general anaesthesia in the dog. ( Dart, CM; Hodgson, DR; Perkins, NR; Pottie, RG, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 10 (41.67) | 29.6817 |
| 2010's | 9 (37.50) | 24.3611 |
| 2020's | 4 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ikeda, T | 3 |
| Amorim, E | 1 |
| Miyazaki, Y | 1 |
| Kato, R | 1 |
| Marutani, E | 1 |
| Silverman, MG | 1 |
| Malhotra, R | 1 |
| Solt, K | 1 |
| Ichinose, F | 1 |
| Wang, L | 1 |
| Chen, B | 1 |
| Liu, T | 1 |
| Luo, T | 1 |
| Kang, W | 1 |
| Liu, W | 2 |
| Roth, JV | 1 |
| Braitman, LE | 1 |
| Hunt, LH | 1 |
| Sabharwal, V | 1 |
| Poongkunran, M | 1 |
| Talahma, M | 1 |
| Iwuchukwu, IO | 1 |
| Ramsay, E | 1 |
| Khan, F | 1 |
| Menon, U | 1 |
| Ciccotto, G | 1 |
| Khandker, N | 1 |
| McGrade, H | 1 |
| Lee, JH | 1 |
| Heo, HJ | 1 |
| Kim, YY | 1 |
| Baek, SM | 1 |
| Kim, KM | 1 |
| Jung, DW | 1 |
| Hao, H | 1 |
| Wang, S | 1 |
| Tan, X | 1 |
| Xiong, X | 1 |
| Yang, J | 1 |
| Xiao, X | 1 |
| Ohe, Y | 1 |
| Kunimasa, K | 1 |
| Watanabe, Y | 1 |
| Darvall, J | 1 |
| Vijayakumar, R | 1 |
| Leslie, K | 1 |
| Bornkamp, JL | 1 |
| Robertson, S | 1 |
| Isaza, NM | 1 |
| Harrison, K | 1 |
| DiGangi, BA | 1 |
| Pablo, L | 1 |
| Imoto, A | 1 |
| Yokoyama, T | 1 |
| Suwa, K | 1 |
| Yamasaki, F | 1 |
| Yatabe, T | 1 |
| Yokoyama, R | 1 |
| Yamashita, K | 1 |
| Selldén, E | 1 |
| Oliver, JA | 1 |
| Clark, L | 1 |
| Corletto, F | 1 |
| Gould, DJ | 1 |
| Snoeijs, MG | 1 |
| Vaahtera, L | 1 |
| de Vries, EE | 1 |
| Schurink, GW | 1 |
| Haenen, GR | 1 |
| Peutz-Kootstra, CJ | 1 |
| Buurman, WA | 1 |
| van Heurn, LW | 1 |
| Parkkinen, J | 1 |
| Sakamoto, T | 1 |
| Kawaguchi, M | 1 |
| Kakimoto, M | 1 |
| Inoue, S | 1 |
| Takahashi, M | 1 |
| Furuya, H | 1 |
| Read, MR | 1 |
| Kinoshita, T | 1 |
| Suzuki, M | 1 |
| Shimada, Y | 1 |
| Ogawa, R | 1 |
| Preisman, S | 1 |
| Marks, R | 1 |
| Nahtomi-Shick, O | 1 |
| Sidi, A | 1 |
| Zeller, A | 1 |
| Arras, M | 1 |
| Lazaris, A | 1 |
| Jurd, R | 1 |
| Rudolph, U | 1 |
| Pottie, RG | 1 |
| Dart, CM | 1 |
| Perkins, NR | 1 |
| Hodgson, DR | 1 |
| Kanakura, H | 1 |
| Taniguchi, T | 1 |
| Sessler, DI | 3 |
| Kikura, M | 1 |
| Kazama, T | 2 |
| Ikeda, K | 1 |
| Sato, S | 2 |
| Caldwell, JE | 1 |
| Heier, T | 1 |
| Wright, PM | 1 |
| Lin, S | 1 |
| McCarthy, G | 1 |
| Szenohradszky, J | 1 |
| Sharma, ML | 1 |
| Hing, JP | 1 |
| Schroeder, M | 1 |
| Toriyama, S | 1 |
| Niwa, K | 1 |
| Shimada, C | 1 |
| Sahin, A | 1 |
| Aypar, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Comparison of the Effect on Temperature Between Patients Induced With Intravenous Propofol vs Inhalation Induction With Sevoflurane[NCT02331108] | 331 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| The Effect Of Forced Air Warming Used For Different Body Parts During Caseraen Section On Maternal Hypothermia, Shivering, Thermal Comfort, Apgar Score And Breastfeeding: Randomized Controlled Trial[NCT04667000] | 35 participants (Anticipated) | Interventional | 2021-05-01 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Blood pressure decrease after intravenous anesthetic induction (NCT02331108)
Timeframe: intraoperative
| Intervention | percentage of patients (Number) |
|---|---|
| Propofol, Age <56 | 49 |
| Propofol With Phenylephrine, Age <56 | 29 |
Percentage of patients who had at least one temperature below 36.0 degrees C in the first hour of anesthesia (NCT02331108)
Timeframe: Intraoperative
| Intervention | Percentage (Number) |
|---|---|
| Sevoflurane in 100% Oxygen, Age <56 | 8 |
| Sevoflurane in 50% Nitrous, Age <56 | 8 |
| Propofol, Age <56 | 30 |
| Propofol With Phenylephrine, Age <56 | 8 |
| Sevoflurane in 100% Oxygen, Age >55 | 14 |
| Sevoflurane in 50% Nitrous, Age >55 | 14 |
Core temperature at 15 minute intervals (NCT02331108)
Timeframe: intraoperative
| Intervention | degree C (Mean) | |||
|---|---|---|---|---|
| 15 minute temperature | 30 minute temperature | 45 minute temperature | 60 minute temperature | |
| Propofol With Phenylephrine, Age <56 | 36.35 | 36.36 | 36.45 | 36.51 |
| Propofol, Age <56 | 35.96 | 35.95 | 36.00 | 36.03 |
| Sevoflurane in 100% Oxygen, Age <56 | 36.42 | 36.41 | 36.47 | 36.52 |
| Sevoflurane in 100% Oxygen, Age >55 | 36.34 | 36.31 | 36.29 | 36.34 |
| Sevoflurane in 50% Nitrous, Age <56 | 36.44 | 36.48 | 36.50 | 36.57 |
| Sevoflurane in 50% Nitrous, Age >55 | 36.41 | 36.38 | 36.41 | 36.44 |
8 trials available for propofol and Hypothermia, Accidental
| Article | Year |
|---|---|
Induction techniques that reduce redistribution hypothermia: a prospective, randomized, controlled, single blind effectiveness study.
Topics: Adolescent; Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Female; Humans; Hypothermia; I | 2019 |
Prewarming neurosurgical patients to minimize hypotension on induction of anesthesia: a randomized trial.
Topics: Adult; Aged; Anesthetics, Intravenous; Blood Pressure; Body Temperature; Female; Heart Rate; Humans; | 2016 |
Effects of anesthetic induction with a benzodiazepine plus ketamine hydrochloride or propofol on hypothermia in dogs undergoing ovariohysterectomy.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Benzodiazepines; Blood Pressure; Body Temperature; Dog | 2016 |
Effect of low-dose ketamine on redistribution hypothermia during spinal anesthesia sedated by propofol.
Topics: Adult; Aged; Anesthesia, Spinal; Anti-Infective Agents; Body Temperature; Female; Humans; Hypothermi | 2004 |
Less core hypothermia when anesthesia is induced with inhaled sevoflurane than with intravenous propofol.
Topics: Adult; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Body Temperature Regulation; F | 1999 |
Temperature-dependent pharmacokinetics and pharmacodynamics of vecuronium.
Topics: Adult; Alfentanil; Anesthesia, Inhalation; Anesthetics, Intravenous; Body Temperature; Female; Human | 2000 |
Induction of anesthesia with ketamine reduces the magnitude of redistribution hypothermia.
Topics: Adult; Anesthesia; Anesthetics, Dissociative; Anesthetics, Intravenous; Body Temperature; Female; He | 2001 |
Effect of amino acid solutions on intraoperative hypothermia and postoperative shivering. Comparison of two anesthetic regimens.
Topics: Amino Acids; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Female; Humans; | 2002 |
16 other studies available for propofol and Hypothermia, Accidental
| Article | Year |
|---|---|
Post-cardiac arrest Sedation Promotes Electroencephalographic Slow-wave Activity and Improves Survival in a Mouse Model of Cardiac Arrest.
Topics: Animals; Cardiopulmonary Resuscitation; Dexmedetomidine; Disease Models, Animal; Electroencephalogra | 2022 |
Risk factors for delayed neurocognitive recovery in elderly patients undergoing thoracic surgery.
Topics: Aged; Female; Humans; Hypothermia; Male; Middle Aged; Postoperative Complications; Propofol; Risk Fa | 2023 |
Secondary hypothermia in patients with super-refractory status epilepticus managed with propofol and ketamine.
Topics: Adult; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Disease Management; Female; Hum | 2020 |
The effect of interscalene brachial plexus block with propofol sedation on preventing perioperative hypothermia during arthroscopic shoulder surgery.
Topics: Aged; Anesthesia, General; Brachial Plexus Block; Humans; Hypothermia; Propofol; Retrospective Studi | 2021 |
Hypothermia induced by anesthesia regulates various signals expressions in the hippocampus of animals.
Topics: Anesthesia; Animals; Astrocytes; Cell Line, Tumor; Cognition; Gene Expression Regulation; Hippocampu | 2017 |
Effects of hypothermia during propofol anesthesia on learning and memory ability and hippocampal apoptosis in neonatal rats.
Topics: Anesthesia; Animals; Animals, Newborn; Apoptosis; Cyclic AMP Response Element-Binding Protein; Hippo | 2019 |
[Effects of amino acid infusion in preventing intraoperative hypothermia: comparison between sevoflurane versus propofol].
Topics: Aged; Aged, 80 and over; Amino Acids; Anesthesia, Epidural; Anesthesia, General; Body Temperature; D | 2014 |
Bolus oral or continuous intestinal amino acids reduce hypothermia during anesthesia in rats.
Topics: Administration, Oral; Amino Acids; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intrav | 2010 |
A comparison of anesthetic complications between diabetic and nondiabetic dogs undergoing phacoemulsification cataract surgery: a retrospective study.
Topics: Acepromazine; Anesthesia, Intravenous; Animals; Bradycardia; Cataract; Diabetes Mellitus; Dog Diseas | 2010 |
Addition of a water-soluble propofol formulation to preservation solution in experimental kidney transplantation.
Topics: Alkanes; Anesthetics, Intravenous; Animals; Antioxidants; Cells, Cultured; Chemistry, Pharmaceutical | 2011 |
The effect of hypothermia on myogenic motor-evoked potentials to electrical stimulation with a single pulse and a train of pulses under propofol/ketamine/fentanyl anesthesia in rabbits.
Topics: Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Blood Gas Analysi | 2003 |
Evaluation of the use of anesthesia and analgesia in reptiles.
Topics: Analgesia; Analgesics; Anesthesia; Anesthetics, Inhalation; Animals; Butorphanol; Humans; Hypothermi | 2004 |
Preservation of static and dynamic cerebral autoregulation after mild hypothermic cardiopulmonary bypass.
Topics: Aged; Anesthetics, Combined; Blood Flow Velocity; Cardiopulmonary Bypass; Cerebral Arteries; Female; | 2005 |
Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofol.
Topics: Anesthetics, General; Anesthetics, Intravenous; Animals; Blood Gas Analysis; Etomidate; Female; Geno | 2005 |
Effect of hypothermia on recovery from general anaesthesia in the dog.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous; An | 2007 |
The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia.
Topics: Anesthetics, Intravenous; Animals; Anti-Inflammatory Agents; Blood Gas Analysis; Blood Pressure; Dis | 2007 |