Page last updated: 2024-11-03

propofol and Hypotension

propofol has been researched along with Hypotension in 291 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

Research Excerpts

ExcerptRelevanceReference
" This study aimed to compare the efficacy of isoflurane-remifentanil (I-R) versus propofol-remifentanil (P-R) to induce controlled hypotension and to assess surgeon satisfaction with each of these combinations during rhinoplasty."9.69Efficacy of Isoflurane-Remifentanil versus Propofol-Remifentanil on Controlled Hypotension and Surgeon Satisfaction in Rhinoplasty: A Single-Blind Clinical Trial Study. ( Abbasi, R; Abbasi, S; Dehghanpisheh, L; Kaboodkhani, R; Khademi, S; Rafati, Z; Sahmeddini, MA; Samadi, K, 2023)
"BACKGROUND This prospective, randomized, controlled study evaluated the efficacy and safety of remimazolam tosilate sedation with adjuvant sufentanil, relative to propofol, for Chinese patients with liver cirrhosis undergoing gastroscopy."9.51Remimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing Gastroscopy: A Randomized Controlled Study. ( Cao, Y; Chi, P; Lv, W; Quan, Z; Xue, FS; Zhou, C, 2022)
" Therefore, the present study sought to evaluate the effect of different doses of esketamine compared with the effect of fentanyl on incidence of perioperative hypotension in patients undergoing painless abortion surgery and to explore the optimal esketamine dose for this population."9.51Effect of different doses of esketamine compared with fentanyl combined with propofol on hypotension in patients undergoing painless abortion surgery: a prospective, randomized, double-blind controlled clinical trial. ( Chen, J; Hu, B; Shen, M; Wang, F; Yang, Y; Zhou, Q; Zou, X, 2022)
"In geriatric patients, hypotension is often reported after general anesthesia induction using propofol."9.51Hypotension after general anesthesia induction using remimazolam in geriatric patients: Protocol for a double-blind randomized controlled trial. ( Goto, T; Masui, K; Mihara, T; Saigusa, Y; Takaki, R; Yamamoto, N; Yokose, M, 2022)
"Hypotension is common during propofol sedation for colonoscopy and of a magnitude and duration associated with harm in surgical patients."9.22Hypotension during propofol sedation for colonoscopy: a retrospective exploratory analysis and meta-analysis. ( Absalom, AR; Barends, CRM; Jones, JB; Sneyd, JR, 2022)
"Phenylephrine 200mcg is more effective than 100mcg in attenuating propofol induced hypotension, especially during the first two minutes after induction, in patients aged 55 years and above."9.22The effect of prophylactic phenylephrine on systemic hypotension during induction of anaesthesia with propofol in patients over 55 years old. ( Kwok, FY; Venugobal, S, 2016)
"Propofol is commonly used in pediatric sedation, which may cause hypotension during induction."9.20A presedation fluid bolus does not decrease the incidence of propofol-induced hypotension in pediatric patients. ( Aldag, JC; Deshpande, GG; Jager, MD, 2015)
"The utilization of phenylephrine to correct hypotension induced by anesthesia has a negative impact on S(c)O(2) while ephedrine maintains frontal lobe oxygenation potentially related to an increase in CO."9.14Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension. ( Brassard, P; Jørgensen, TB; Nissen, P; Secher, NH, 2010)
"This study was conducted to examine whether pretreatment with intravenous atropine could prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil in a prospective randomized placebo-controlled manner."9.14Can intravenous atropine prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil? ( Ariyama, J; Hayashida, M; Kitamura, A; Maruyama, K; Nakagawa, H; Nishikawa, Y, 2010)
"The present study compared the efficacy of preloading with colloid "Haemaccel" with vasoconstrictor (intravenous ephedrine sulphate) in preventing hypotension during propofol induction."9.13Prevention of hypotension during propofol induction: a comparison of preloading with 3.5% polymers of degraded gelatin (Haemaccel) and intravenous ephedrine. ( Bhadani, UK; Bhattarai, BK; Biswas, BK; Dhungana, Y; Tripathi, M, 2008)
"Propofol produces anaesthesia with rapid recovery but also causes pain or discomfort on injection."9.13Prevention of propofol-induced injection pain by sufentanil: a placebo-controlled comparison with remifentanil. ( Honarmand, A; Safavi, M, 2008)
"Propofol is twice as likely as etomidate to evoke hypotension in anaesthesia induction of patients with severe aortic stenosis; however, etomidate transiently decreases post-operative serum cortisol concentrations."9.12Propofol causes more hypotension than etomidate in patients with severe aortic stenosis: a double-blind, randomized study comparing propofol and etomidate. ( Bendel, S; Pölönen, P; Ruokonen, E; Uusaro, A, 2007)
"Phenylephrine in doses of 100 micrograms effectively attenuates anticipated hypotension upon induction of general anaesthesia with propofol."9.12Attenuation of hypotension using phenylephrine during induction of anaesthesia with propofol. ( Imran, M; Khan, FH; Khan, MA, 2007)
"This prospective, randomized, double-blinded study was designed to compare the effects of desflurane, isoflurane and sevoflurane when combined with remifentanil for induced hypotension on surgical conditions and operative field during tympanoplasty."9.11Induced hypotension for tympanoplasty: a comparison of desflurane, isoflurane and sevoflurane. ( Aypar, U; Başgül, E; Celiker, V; Dal, D; Ozer, E; Salman, MA, 2004)
"This prospective, double-blind, randomized, placebo-controlled study compares the effects of ephedrine and ketamine on injection pain, and hypotension from propofol."9.11Comparison of ephedrine and ketamine in prevention of injection pain and hypotension due to propofol induction. ( Altunkaya, H; Ayoğlu, H; Ciçek, E; Demirel, CB; Ozer, Y; Ozkoçak, I, 2005)
"In patients chronically treated with angiotensin converting-enzyme inhibitors (ACEI), typically selected doses of ephedrine do not always restore arterial blood pressure when anesthesia-induced hypotension occurs."9.10Terlipressin-ephedrine versus ephedrine to treat hypotension at the induction of anesthesia in patients chronically treated with angiotensin converting-enzyme inhibitors: a prospective, randomized, double-blinded, crossover study. ( Bertrand, M; Brun, L; Coriat, P; Gourdin, M; Meersschaert, K; Mouren, S; Riou, B, 2002)
"Nicardipine-, nitroglycerin-, and prostaglandin E1-induced hypotension attenuate the human cerebrovascular CO2 reactivity during propofol-fentanyl anesthesia."9.09Effects of nicardipine-, nitroglycerin-, and prostaglandin E1-induced hypotension on human cerebrovascular carbon dioxide reactivity during propofol-fentanyl anesthesia. ( Endoh, H; Honda, T; Komura, N; Shibue, C; Shimoji, K; Watanabe, I, 1999)
"We conducted a double-blind, randomised, placebo-controlled study evaluating the efficacy of prophylactic metaraminol for preventing propofol-induced hypotension."9.09The effect of prophylactic metaraminol on systemic hypotension caused by induction of anaesthesia with propofol in patients over 55 years old. ( Chiu, CL; Tew, GP; Wang, CY, 2001)
"The objective of this study was to determine the effectiveness of two prophylactic approaches against the anticipated hypotension induced by propofol during rapid-sequence intubation."9.08Prophylaxis against the systemic hypotension induced by propofol during rapid-sequence intubation. ( el-Beheiry, H; Kim, J; Milne, B; Seegobin, R, 1995)
"We compared propofol with high-dose barbiturates in the treatment of refractory status epilepticus (RSE) and propose a protocol for the administration of propofol in RSE in adults, correlating propofol's effect with plasma levels."9.08Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. ( Dulaney, E; Kramer, TH; O'Meeghan, R; Raps, EC; Skaar, DJ; Stecker, MM, 1998)
"The present investigation explored the possibility that the commonly observed hypotension that occurs during induction of anesthesia with propofol might be related to its ability to produce venodilation."9.07Venodilation contributes to propofol-mediated hypotension in humans. ( Berens, RA; Ebert, TJ; Kampine, JP; Muzi, M, 1992)
"These findings suggest that 5-ALA-HCl does not affect the antihypertensive agents-induced hypotensive effect, but enhances the bupivacaine-induced hypotensive effect, especially in SHRs, indicating that 5-ALA may contribute to anesthesia-induced hypotension via suppression of sympathetic nerve activity in patients with hypertension."8.315-Aminolevulinic acid hydrochloride enhances bupivacaine-induced hypotension in spontaneously hypertensive rats. ( Abe, M; Fukuda, N; Hara, T; Ishizuka, M; Ito, H; Katakawa, M; Otsuka, N, 2023)
"In this study, the aim was to research the effects of smoking habits on controlled hypotension administered with nitroglycerin during ear-nose-throat surgery."8.31Effects of smoking on controlled hypotension with nitroglycerin during ear-nose-throat surgery. ( Ersoy, A; Sinoglu, B, 2023)
"The primary exposure was total propofol induction dose in mg/kg, and the primary outcome was occurrence of severe hypotension (MAP≤55 mmHg) prior to surgical incision, stratified by non-invasive vs."8.12Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65. ( Akhtar, S; Bardia, A; Burg, MM; Dai, F; Kheterpal, S; Mathis, M; Michel, G; Schonberger, RB; Shah, N; Vaughn, MT, 2022)
"Although the largest decrease in propofol dosage required for intubation was after IV premedication with acepromazine and butorphanol, hypotension and apnea still occurred."8.12Effects of intravenous acepromazine and butorphanol on propofol dosage for induction of anesthesia in healthy Beagle dogs. ( Dantino, SC; Kleine, SA; Seddighi, R; Smith, CK; Smith, SM; Zhu, X, 2022)
"The development of hypotension on administration of intravenous propofol is common and independently associated with adverse outcomes."8.02Predicting hypotension during anesthesia: Variation in pulse oximetry plethysmography predicts propofol-induced hypotension in children. ( Choi, SN; Jang, YE; Ji, SH; Kim, EH; Kim, HS; Kim, JT; Lee, JH, 2021)
" This report describes a case of severe bradyarrhythmia during anesthetic induction with propofol, midazolam, sufentanil, and vecuronium."8.02Bradyarrhythmia and hypotension during anesthetic induction-reconsideration of nifedipine: a case report. ( Zhang, X, 2021)
" We hypothesised that anaesthesia-induced hypotension causes renal vasoconstriction and decreased oxygen delivery via angiotensin II-mediated renal vasoconstriction."7.96Pre-treatment with the angiotensin receptor 1 blocker losartan protects renal blood flow and oxygen delivery after propofol-induced hypotension in pigs. ( Franzén, S; Frithiof, R, 2020)
"In early 2015, clinicians throughout Zambia noted a range of unpredictable adverse events after the administration of propofol, including urticaria, bronchospasm, profound hypotension, and most predictably an inadequate depth of anesthesia."7.85An Analysis of Substandard Propofol Detected in Use in Zambian Anesthesia. ( Attaran, A; Bould, MD; Curtis, S; Mayer, P; Mumphansha, H; Nickerson, JW; Overton, S, 2017)
"Hypotension is a common side effect of propofol, but there are no reliable methods to determine which patients are at risk for significant propofol-induced hypotension (PIH)."7.83Ultrasound measurement of inferior vena cava collapse predicts propofol-induced hypotension. ( Au, AK; Fields, JM; Ku, BS; Papanagnou, D; Shirazi, M; Steinberg, D; Thom, C, 2016)
"A multicenter, retrospective, propensity-matched pilot study was conducted comparing patients with sepsis or severe sepsis who received CIV propofol for sedation to those who did not."7.83Effects of propofol on vasopressor use in patients with sepsis and severe sepsis: A pilot study. ( Boucher, AN; Jones, GM; Kimmons, LA; Marler, J; Mohrien, K; Oliphant, CS; Vandigo, JE, 2016)
"Hypotension was the most frequent anesthetic complication during procedure under propofol-based deep sedation, but this method was safe and effective under appropriate monitoring."7.81Age correlates with hypotension during propofol-based anesthesia for endoscopic retrograde cholangiopancreatography. ( Khoi, CS; Lin, TY; Lu, CW; Wang, HC; Wong, JJ, 2015)
" Univariate analyses were performed to determine risk factors associated with severe hypotension during sedation with propofol."7.80Predictors of severe hypotension in neurocritical care patients sedated with propofol. ( Doepker, BA; Elijovich, L; Erdman, MJ; Jones, GM; Kimmons, LA, 2014)
" We report a case of profound hypotension after anesthesia induction with propofol in a patient who was treated with two 600 mg doses of rifampin for prophylaxis of infection before surgery."7.79Case report: profound hypotension after anesthetic induction with propofol in patients treated with rifampin. ( Ehrenfeld, JM; Jiang, Y; Mirzakhani, H; Nozari, A; Peterfreund, R; Rosow, C; Sandberg, W; Szabo, M; Walsh, JL; Wang, J, 2013)
"Although obesity was associated with an increased frequency of SRCs, propofol sedation can be used safely in obese patients undergoing AEPs when administered by trained professionals."7.77Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures. ( Azar, R; Cote, GA; Early, D; Edmundowicz, SA; Hall, M; Hovis, CE; Hovis, RM; Jonnalagadda, SS; Kushnir, V; Mullady, DK; Murad, F; Waldbaum, L; Wani, S, 2011)
" Propofol generally offered good intubating conditions, but we encountered severe problems with arterial hypotension."7.76Propofol as an induction agent for endotracheal intubation can cause significant arterial hypotension in preterm neonates. ( Eifinger, F; Huenseler, C; Kribs, A; Oberthuer, A; Roth, B; Welzing, L, 2010)
"The authors report a case of short-term high-dose propofol-related metabolic acidosis in a 3-year-old girl."7.74Early propofol infusion syndrome following cerebral angiographic embolization for giant aneurysm repair. Case report. ( Muhonen, MG; Nwagwu, CI; Westhout, FD, 2007)
"In two patients, pheochromocytoma resection was performed under propofol/fentanyl anesthesia, while bispectral index (BIS) monitoring and blood volume measurement using pulse spectrophotometry were done."7.73[Anesthetic management with propofol for pheochromocytoma resection under monitoring of bispectral index and blood volume]. ( Ishida, K; Matsumoto, M; Morimoto, Y; Orita, H; Sakabe, T; Tsuruta, S; Utada, K, 2006)
" There had not been severe hypotension reported in the literature in consequence of inadvertent epidural thiopental administration."7.73Intravenous propofol precipitates the hypotension induced by inadvertent epidural thiopental injection. ( Chan, KH; Chang, WK; Chu, CC; Huang, SY; Wang, CC, 2006)
"During incomplete cerebral ischemia, the neuroprotective anesthetics sevoflurane and propofol suppressed cerebral increases in norepinephrine and glutamate concentrations."7.72The effect of sevoflurane and propofol on cerebral neurotransmitter concentrations during cerebral ischemia in rats. ( Blobner, M; Engelhard, K; Hoffman, WE; Kochs, E; Matthes, B; Werner, C, 2003)
"Reducing hypotension is crucial as hypotension is the most common side effect of spinal anesthesia, and in older patients with various comorbidities, it can lead to fatality."7.30Norepinephrine prevents hypotension in older patients under spinal anesthesia with intravenous propofol sedation: a randomized controlled trial. ( Cho, J; Kim, H; Kim, HJ; Kim, KS; Koh, WU; Lee, S; Park, SW; Ro, YJ, 2023)
"Propofol is a widely used anesthetic drug because of its minor complication and also its fast effect."6.77Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial. ( Ayatollahi, V; Behdad, S; Kargar, S; Yavari, T, 2012)
" The results of this trial suggest that a propofol-based anesthetic, when compared to an enflurane-based anesthetic requiring additional dosing of fentanyl and midazolam for CPB, can lead to a significant reduction in time to extubation after CABG surgery, without adverse hemodynamic effects, increased risk of myocardial ischemia or infarction."6.68Hemodynamic effects, myocardial ischemia, and timing of tracheal extubation with propofol-based anesthesia for cardiac surgery. ( Buckland, MR; Bujor, MA; Davis, BB; Hunt, JO; Langley, M; McRae, R; Moloney, JT; Myles, PS; Weeks, AM, 1997)
"Propofol sedation has a similar risk of cardiopulmonary adverse events compared with traditional agents for gastrointestinal endoscopic procedures."6.55Similar Risk of Cardiopulmonary Adverse Events Between Propofol and Traditional Anesthesia for Gastrointestinal Endoscopy: A Systematic Review and Meta-analysis. ( Garg, S; Issa, D; Lopez, R; Sanaka, MR; Vargo, JJ; Wadhwa, V, 2017)
"Overall, propofol induced a significant incidence of relative hypotension (mean arterial pressure 20% below baseline, 45%), apnoea (71%) and haemoglobin desaturation (65%) at induction of anaesthesia, with a higher incidence of hypotension and apnoea in the P-CRI than P-TCI group (68% versus 21%, p = 0."5.69Comparison between continuous rate infusion and target-controlled infusion of propofol in dogs: a randomized clinical trial. ( Cuniberti, B; Hughes, JL; Huuskonen, V, 2023)
" With the increasing dose of alfentanil, the morbidity of hypotension and bradycardia increased significantly (P = 0."5.69A comparative study on the efficacy and safety of propofol combined with different doses of alfentanil in gastroscopy: a randomized controlled trial. ( Guan, ZY; Wang, CM; Wang, LL; Zhang, J; Zhang, YW; Zhao, P, 2023)
"Remimazolam confers a lower risk of hypotension than propofol."5.69Comparison of hemodynamics during induction of general anesthesia with remimazolam and target-controlled propofol in middle-aged and elderly patients: a single-center, randomized, controlled trial. ( Kakuta, N; Kawanishi, R; Kinoshita, M; Sakai, Y; Sekiguchi, R; Tanaka, K, 2023)
"Lidocaine-based regimen for induction of anesthesia reduced the risk of postinduction hypotension in older patients compared to the fentanyl-based regimen."5.69Comparison of the hemodynamic effects of opioid-based versus lidocaine-based induction of anesthesia with propofol in older adults: a randomized controlled trial. ( Amin, SM; Arafa, AS; ElSayed, OS; Hasanin, A; Hassan, A; Khaled, D; Mostafa, M, 2023)
"Hypotension is common after anesthesia induction with propofol and is associated with increased morbidity."5.69Hemodynamic effects of a low versus a high dose of propofol during induction of anesthesia. A randomized trial. ( Falk, RS; Hauge, TH; Langesaeter, E; Sjøen, GH; Tønnessen, TI, 2023)
" This study aimed to compare the efficacy of isoflurane-remifentanil (I-R) versus propofol-remifentanil (P-R) to induce controlled hypotension and to assess surgeon satisfaction with each of these combinations during rhinoplasty."5.69Efficacy of Isoflurane-Remifentanil versus Propofol-Remifentanil on Controlled Hypotension and Surgeon Satisfaction in Rhinoplasty: A Single-Blind Clinical Trial Study. ( Abbasi, R; Abbasi, S; Dehghanpisheh, L; Kaboodkhani, R; Khademi, S; Rafati, Z; Sahmeddini, MA; Samadi, K, 2023)
"Remimazolam induction was more stable than propofol induction in preserving normal hemodynamics and was associated with a relatively lower incidence of hypotension."5.69Comparison of remimazolam and propofol induction on hemodynamic response in hypertensive patients. ( Choi, EK; Jang, Y; Park, SJ, 2023)
"Hypotension is the most common adverse event under propofol-mediated sedation and is possible to cause varying degrees of damage to patients."5.69The safety and efficacy of remimazolam tosylate combined with propofol in upper gastrointestinal endoscopy: A multicenter, randomized clinical trial. ( Deng, Y; Dou, Y; Li, D; Liu, X; Ma, S; Wang, X; Wei, A; Wu, J; Yang, M; Zhou, S, 2023)
" Therefore, we aimed to evaluate the effect of ramosetron, a 5-HT3 antagonist, administered on hypotension at the induction of total intravenous anesthesia (TIVA) with propofol and remifentanil."5.69The preventive effect of 5-hydroxytryptamine-3 receptor antagonist on blood pressure reduction and postoperative nausea and vomiting during general anesthesia induction: A double-blinded, randomized controlled trial. ( Hong, SW; Kim, SH, 2023)
"Propofol may result in hypotension, bradycardia and loss of protective reflexes, especially in elderly patients, while esketamine, a N-methyl-D-aspartate receptor antagonist, has analgesic, anaesthetic and sympathomimetic properties and is known to cause less cardiorespiratory depression."5.51The median effective concentration of propofol with different doses of esketamine during gastrointestinal endoscopy in elderly patients: A randomized controlled trial. ( Chen, HY; Ding, T; Liu, W; Song, JC; Yang, B; Yang, H; Zhao, Q, 2022)
" Complications including apnea, hypotension, hypoxia, nausea, and vomiting, along with gastroenterologist satisfaction and patients' pain score (based on Wong-Baker faces pain assessment scale), were recorded by a checklist."5.51Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial. ( Aghaali, M; Ahmadpour, S; Alemi, F; Aminnejad, R; Hormati, A; Hormati, M; Sabouri, SM; Saeidi, M; Shafiee, H, 2022)
"The effectiveness and side effects of dexmedetomidine (DEX) in combination with midazolam and propofol have not been comparatively studied in a single clinical trial as sedative agents to general anesthesia before."5.51Comparison of Intra and Post-operative Sedation Efficacy of Dexmedetomidinemidazolam and Dexmedetomidine-propofol for Major Abdominal Surgery. ( Gao, Y; Yan, F, 2022)
"BACKGROUND This prospective, randomized, controlled study evaluated the efficacy and safety of remimazolam tosilate sedation with adjuvant sufentanil, relative to propofol, for Chinese patients with liver cirrhosis undergoing gastroscopy."5.51Remimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing Gastroscopy: A Randomized Controlled Study. ( Cao, Y; Chi, P; Lv, W; Quan, Z; Xue, FS; Zhou, C, 2022)
" Therefore, the present study sought to evaluate the effect of different doses of esketamine compared with the effect of fentanyl on incidence of perioperative hypotension in patients undergoing painless abortion surgery and to explore the optimal esketamine dose for this population."5.51Effect of different doses of esketamine compared with fentanyl combined with propofol on hypotension in patients undergoing painless abortion surgery: a prospective, randomized, double-blind controlled clinical trial. ( Chen, J; Hu, B; Shen, M; Wang, F; Yang, Y; Zhou, Q; Zou, X, 2022)
"In geriatric patients, hypotension is often reported after general anesthesia induction using propofol."5.51Hypotension after general anesthesia induction using remimazolam in geriatric patients: Protocol for a double-blind randomized controlled trial. ( Goto, T; Masui, K; Mihara, T; Saigusa, Y; Takaki, R; Yamamoto, N; Yokose, M, 2022)
"Remimazolam was associated with a lower rate of hypotension in elderly patients undergoing upper gastrointestinal endoscopy under deep sedation/anaesthesia than propofol."5.51Remimazolam versus propofol for deep sedation/anaesthesia in upper gastrointestinal endoscopy in elderly patients: A multicenter, randomized controlled trial. ( Fu, L; Huang, H; Huang, Y; Jiang, J; Liao, Y; Ling, W; Lu, K; Ma, C; Pan, M; Qin, Z; Ran, X; Wang, M; Wei, N; Wei, Q; Wei, S; Wei, Y; Xiong, B, 2022)
" Both propofol and dexmedetomidine proved to be adequate and safe medications in the sedation of autistic children undergoing MRI."5.48A Comparison of Safety and Efficacy of Dexmedetomidine and Propofol in Children with Autism and Autism Spectrum Disorders Undergoing Magnetic Resonance Imaging. ( Abulebda, K; Ahmed, SS; Louer, R; Lutfi, R, 2018)
" Current clinical studies have focused on the use of remimazolam and propofol for general anesthesia (GA) as indicators of safety outcomes in surgical patients, but different studies have reached different conclusions."5.41Comparison of remimazolam and propofol about safety outcome indicators during general anesthesia in surgical patients: a systematic review and meta-analysis. ( An, L; Bai, X; Chen, R; Gao, H; Huang, X; Tong, R; Wang, C; Wu, X; Yi, J; Zhang, Z, 2023)
" Propofol is the most widely used agent for induction of anesthesia and sedation by anesthesiologists."5.41Remimazolam ( Chang, Y; Chi, KY; Huang, YT, 2023)
"Propofol was commenced in all patients at a mean infusion rate of 18."5.38Propofol sedation administered by cardiologists without assisted ventilation for long cardiac interventions: an assessment of 1000 consecutive patients undergoing atrial fibrillation ablation. ( Drewitz, I; Heitmann, K; Hoffmann, BA; Rostock, T; Salukhe, TV; Steven, D; Willems, S, 2012)
"Propofol is an intravenous anesthetic that is widely used to anesthetize patients during neurosurgical procedures."5.38Opioid receptor blockade prevents propofol-induced hypotension in rats. ( de Moura, RS; Lessa, MA; Maracajá-Neto, LF; Mello Silva, GA; Tibiriçá, E, 2012)
" We aimed to establish whether the duration of preoperative abstinence from fluids independently contributed to arterial blood pressure changes and dosage requirements during propofol induction."5.36The influence of duration of fluid abstinence on hypotension during propofol induction. ( Lewis, CM; Morley, AP; Nalla, BP; Natarajan, A; Prevost, AT; Strandvik, G; Vamadevan, S, 2010)
"Pharmacologic angiotensin axis blockade (AAB) has been associated with profound hypotension following anesthetic induction with propofol."5.30A randomized controlled trial comparing methohexital and propofol for induction in patients receiving angiotensin axis blockade. ( Adhikary, S; Bonavia, A; Budde, A; Kunselman, A; Lyn-Sue, J; Mets, B; Verbeek, T, 2019)
"Propofol is commonly used with remifentanil for induction of general anesthesia (GA); however, it often leads to hypotension."5.30Comparison between hemodynamic effects of propofol and thiopental during general anesthesia induction with remifentanil infusion: a double-blind, age-stratified, randomized study. ( Hino, H; Kihara, Y; Matsuura, T; Mori, T; Nishikawa, K; Tsujikawa, S, 2019)
"It is unknown to what extent hypotension frequently observed following administration of propofol for induction of general anesthesia is caused by overdosing propofol."5.27Bispectral index to guide induction of anesthesia: a randomized controlled study. ( Arndt, C; Eberhart, L; Nageldick, D; Rüsch, D; Tappert, S; Wulf, H, 2018)
"Hypotension is common during propofol sedation for colonoscopy and of a magnitude and duration associated with harm in surgical patients."5.22Hypotension during propofol sedation for colonoscopy: a retrospective exploratory analysis and meta-analysis. ( Absalom, AR; Barends, CRM; Jones, JB; Sneyd, JR, 2022)
"Both dexmedetomidine and propofol can effectively reduce anxiety levels of claustrophobic adults undergoing MRI, but dexmedetomidine takes longer to achieve adequate anxiolysis and sleep and may have an effect on image quality."5.22Comparing the efficacy and safety between propofol and dexmedetomidine for sedation in claustrophobic adults undergoing magnetic resonance imaging (PADAM trial). ( Ariffin, MA; Chan, L; Lai, LL; Loh, PS; Rai, V; Ramli, N, 2016)
"Phenylephrine 200mcg is more effective than 100mcg in attenuating propofol induced hypotension, especially during the first two minutes after induction, in patients aged 55 years and above."5.22The effect of prophylactic phenylephrine on systemic hypotension during induction of anaesthesia with propofol in patients over 55 years old. ( Kwok, FY; Venugobal, S, 2016)
" Hypotension induced by plasma target-controlled infusion of propofol could mainly be attributed to decreased stroke volume instead of vascular dilation."5.20Hemodynamic responses during induction: comparison of Marsh and Schnider pharmacokinetic models. ( Feng, X; Niu, LJ; Yang, L; Yang, XY; Zhou, X; Zhou, ZB, 2015)
"The results of this study suggest that nitrous oxide inhalation combined with propofol sedation attenuates the hypotensive effect and pain associated with propofol injections, along with potentiating the amnesic effect."5.20A prospective, randomized controlled trial of conscious sedation using propofol combined with inhaled nitrous oxide for dental treatment. ( Hanamoto, H; Kudo, C; Morimoto, Y; Niwa, H; Sugimura, M; Yokoe, C, 2015)
"Propofol is commonly used in pediatric sedation, which may cause hypotension during induction."5.20A presedation fluid bolus does not decrease the incidence of propofol-induced hypotension in pediatric patients. ( Aldag, JC; Deshpande, GG; Jager, MD, 2015)
" Hypotension events, induction and recovery time and propofol doses were not different."5.17The potential regimen of target-controlled infusion of propofol in flexible bronchoscopy sedation: a randomized controlled trial. ( Hsieh, CH; Kuo, HP; Lin, HC; Lin, TY; Lo, YL; Ni, YL; Wang, CH; Wang, TY; Yu, CT, 2013)
"This study shows that high doses of propofol are needed to reach effective sedation in neonates for intubation, with hypotension as a side effect in a considerable percentage of patients."5.17Clinical evaluation of propofol as sedative for endotracheal intubation in neonates. ( Reiss, IK; Simons, SH; van der Lee, R; van Weissenbruch, MM, 2013)
"Our study showed that the use of propofol resulted in less hypertension and tachycardia at and after intubation than etomidate."5.17Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized, clinical trial. ( Kamenik, M; Möller Petrun, A, 2013)
"Patients scheduled to undergo ESD for early gastric cancer or adenoma were randomly assigned to sedation with midazolam or propofol, and consciousness level was evaluated by bispectral index (BIS) monitoring."5.16Propofol sedation with bispectral index monitoring is useful for endoscopic submucosal dissection: a randomized prospective phase II clinical trial. ( Azuma, M; Higuchi, K; Ishido, K; Katada, C; Koizumi, W; Naruke, A; Sasaki, T; Sato, A; Tanabe, S, 2012)
"The utilization of phenylephrine to correct hypotension induced by anesthesia has a negative impact on S(c)O(2) while ephedrine maintains frontal lobe oxygenation potentially related to an increase in CO."5.14Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension. ( Brassard, P; Jørgensen, TB; Nissen, P; Secher, NH, 2010)
"This study was conducted to examine whether pretreatment with intravenous atropine could prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil in a prospective randomized placebo-controlled manner."5.14Can intravenous atropine prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil? ( Ariyama, J; Hayashida, M; Kitamura, A; Maruyama, K; Nakagawa, H; Nishikawa, Y, 2010)
"The present study compared the efficacy of preloading with colloid "Haemaccel" with vasoconstrictor (intravenous ephedrine sulphate) in preventing hypotension during propofol induction."5.13Prevention of hypotension during propofol induction: a comparison of preloading with 3.5% polymers of degraded gelatin (Haemaccel) and intravenous ephedrine. ( Bhadani, UK; Bhattarai, BK; Biswas, BK; Dhungana, Y; Tripathi, M, 2008)
"Propofol produces anaesthesia with rapid recovery but also causes pain or discomfort on injection."5.13Prevention of propofol-induced injection pain by sufentanil: a placebo-controlled comparison with remifentanil. ( Honarmand, A; Safavi, M, 2008)
"Propofol is twice as likely as etomidate to evoke hypotension in anaesthesia induction of patients with severe aortic stenosis; however, etomidate transiently decreases post-operative serum cortisol concentrations."5.12Propofol causes more hypotension than etomidate in patients with severe aortic stenosis: a double-blind, randomized study comparing propofol and etomidate. ( Bendel, S; Pölönen, P; Ruokonen, E; Uusaro, A, 2007)
"Phenylephrine in doses of 100 micrograms effectively attenuates anticipated hypotension upon induction of general anaesthesia with propofol."5.12Attenuation of hypotension using phenylephrine during induction of anaesthesia with propofol. ( Imran, M; Khan, FH; Khan, MA, 2007)
"In 60 patients undergoing inguinal hernia repair, we compared the clinical profile of unilateral spinal anesthesia produced with either 8 mg of hyperbaric bupivacaine 0."5.11A prospective, randomized, double-blind comparison of unilateral spinal anesthesia with hyperbaric bupivacaine, ropivacaine, or levobupivacaine for inguinal herniorrhaphy. ( Casati, A; Marchetti, C; Moizo, E; Vinciguerra, F, 2004)
"This prospective, randomized, double-blinded study was designed to compare the effects of desflurane, isoflurane and sevoflurane when combined with remifentanil for induced hypotension on surgical conditions and operative field during tympanoplasty."5.11Induced hypotension for tympanoplasty: a comparison of desflurane, isoflurane and sevoflurane. ( Aypar, U; Başgül, E; Celiker, V; Dal, D; Ozer, E; Salman, MA, 2004)
"4%), including hypotension in 5, hypoxemia in 7, and apnea in 5."5.11Propofol for deep procedural sedation in the ED. ( Baire, M; Frazee, BW; Lowery, D; Park, RS, 2005)
"This prospective, double-blind, randomized, placebo-controlled study compares the effects of ephedrine and ketamine on injection pain, and hypotension from propofol."5.11Comparison of ephedrine and ketamine in prevention of injection pain and hypotension due to propofol induction. ( Altunkaya, H; Ayoğlu, H; Ciçek, E; Demirel, CB; Ozer, Y; Ozkoçak, I, 2005)
"We evaluated the effectiveness of intentional hypercapnia against hypotension after induction of anaesthesia with thiopental and isoflurane (TI) or propofol (P)."5.11Effect of hypercapnia on arterial hypotension after induction of anaesthesia. ( Enoki, T; Fukuda, K; Nomura, R; Shinomura, T; Tsuchiya, N, 2005)
"In patients chronically treated with angiotensin converting-enzyme inhibitors (ACEI), typically selected doses of ephedrine do not always restore arterial blood pressure when anesthesia-induced hypotension occurs."5.10Terlipressin-ephedrine versus ephedrine to treat hypotension at the induction of anesthesia in patients chronically treated with angiotensin converting-enzyme inhibitors: a prospective, randomized, double-blinded, crossover study. ( Bertrand, M; Brun, L; Coriat, P; Gourdin, M; Meersschaert, K; Mouren, S; Riou, B, 2002)
"Nicardipine-, nitroglycerin-, and prostaglandin E1-induced hypotension attenuate the human cerebrovascular CO2 reactivity during propofol-fentanyl anesthesia."5.09Effects of nicardipine-, nitroglycerin-, and prostaglandin E1-induced hypotension on human cerebrovascular carbon dioxide reactivity during propofol-fentanyl anesthesia. ( Endoh, H; Honda, T; Komura, N; Shibue, C; Shimoji, K; Watanabe, I, 1999)
"We conducted a double-blind, randomised, placebo-controlled study evaluating the efficacy of prophylactic metaraminol for preventing propofol-induced hypotension."5.09The effect of prophylactic metaraminol on systemic hypotension caused by induction of anaesthesia with propofol in patients over 55 years old. ( Chiu, CL; Tew, GP; Wang, CY, 2001)
" A total of 30 patients were randomly allocated for either normotensive anesthesia maintained by continuous infusion of propofol and remifentanil (NORMO, n=10) or hypotensive anesthesia, whereby hypotension was induced by increasing the infusion rate of remifentanil (HYPO-R, n=10) or by administration of nitroglycerin (HYPO-N, n=10)."5.09Influence of hypotensive and normotensive anesthesia on platelet aggregability and hemostatic markers in orthognathic surgery. ( Andel, H; Felfernig, M; Felfernig-Boehm, D; Fleck, T; Kimberger, O; Kinstner, C; Mueller, MR; Salat, A, 2001)
"Pain is a well known complication of propofol injection."5.08Modulating effects of lignocaine on propofol. ( Khoo, ST; Tham, CS, 1995)
"The objective of this study was to determine the effectiveness of two prophylactic approaches against the anticipated hypotension induced by propofol during rapid-sequence intubation."5.08Prophylaxis against the systemic hypotension induced by propofol during rapid-sequence intubation. ( el-Beheiry, H; Kim, J; Milne, B; Seegobin, R, 1995)
"We compared propofol with high-dose barbiturates in the treatment of refractory status epilepticus (RSE) and propose a protocol for the administration of propofol in RSE in adults, correlating propofol's effect with plasma levels."5.08Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. ( Dulaney, E; Kramer, TH; O'Meeghan, R; Raps, EC; Skaar, DJ; Stecker, MM, 1998)
"To investigate clinically important hypotension and bradycardia after induction of anesthesia with propofol, we analyzed data from a Phase IV stepwise study involving 25,981 patients, 1722 institutions, and 1819 anesthesiologists."5.07Hemodynamic effects of propofol: data from over 25,000 patients. ( Apfelbaum, JL; Grasela, TH; Hug, CC; McLeskey, CH; Nahrwold, ML; Roizen, MF; Stanley, TH; Thisted, RA; Walawander, CA; White, PF, 1993)
"The present investigation explored the possibility that the commonly observed hypotension that occurs during induction of anesthesia with propofol might be related to its ability to produce venodilation."5.07Venodilation contributes to propofol-mediated hypotension in humans. ( Berens, RA; Ebert, TJ; Kampine, JP; Muzi, M, 1992)
"This study investigated whether pretreatment with glycopyrronium can attenuate the hypotension caused by anaesthesia of the elderly with propofol."5.07The effect of pre-induction glycopyrronium on the haemodynamic response of elderly patients to anaesthesia with propofol. ( Mayall, R; Sneyd, JR, 1992)
" The effects of propofol on cecal intubation rates, and occurrences of hypotension and apnea were similar to those of TAs."5.05Safety and efficacy of propofol alone or in combination with other agents for sedation of patients undergoing colonoscopy: an updated meta-analysis. ( Li, HT; Xu, H; Zhang, K, 2020)
" Providers of all sedation types should be aware of hypotension, apnea, hypoventilation, and hypoxia that can develop and they should be able to manage the patient under these circumstances."5.01Moderate and deep sedation training and pharmacology for nonanesthesiologists: recommendations for effective practice. ( Beutler, SS; Tran, TT; Urman, RD, 2019)
"We are uncertain whether maintenance with propofol-based TIVA or with inhalational agents affect incidences of postoperative delirium, mortality, or length of hospital stay because certainty of the evidence was very low."4.98Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery. ( Alderson, P; Lewis, SR; Miller, D; Pritchard, MW; Schofield-Robinson, OJ; Shelton, CL; Smith, AF, 2018)
"17), and the reduction in apnea or hyoxemia (OR=0."4.95The Comparison of Etomidate and Propofol Anesthesia in Patients Undergoing Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis. ( Xiao, X; Ye, L; Zhu, L, 2017)
", hypoxia, hypotension, arrhythmia, and apnea) and sedation profiles were assessed."4.89The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis. ( Chen, C; Chen, J; Deng, D; Liu, J; Long, A; Tang, D; Wang, D; Wang, L; Xu, Y; Zhu, Z, 2013)
" The following 4 cardiopulmonary complications were assessed: hypoxia, hypotension, arrhythmias, and apnea."4.82Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis. ( Khandwala, F; Lopez, R; Qadeer, MA; Vargo, JJ; Zuccaro, G, 2005)
"These findings suggest that 5-ALA-HCl does not affect the antihypertensive agents-induced hypotensive effect, but enhances the bupivacaine-induced hypotensive effect, especially in SHRs, indicating that 5-ALA may contribute to anesthesia-induced hypotension via suppression of sympathetic nerve activity in patients with hypertension."4.315-Aminolevulinic acid hydrochloride enhances bupivacaine-induced hypotension in spontaneously hypertensive rats. ( Abe, M; Fukuda, N; Hara, T; Ishizuka, M; Ito, H; Katakawa, M; Otsuka, N, 2023)
"In this study, the aim was to research the effects of smoking habits on controlled hypotension administered with nitroglycerin during ear-nose-throat surgery."4.31Effects of smoking on controlled hypotension with nitroglycerin during ear-nose-throat surgery. ( Ersoy, A; Sinoglu, B, 2023)
" Within 48 h of admission, we compared total amounts of sedation/pain medications (morphine milligram equivalents (MME), propofol, dexmedetomidine, benzodiazepines) with total resuscitation volumes and frequency of hypotensive episodes."4.31The risks of sedation and pain control during burn resuscitation: Increased opioids lead to over-resuscitation and hypotension. ( Anderson, J; Mandell, SP; McClellan, JM; O'Neal, J; Sheckter, C; Stanton, E, 2023)
"The objective of this study was to compare the development of clinically significant hypotension or bradycardia (ie, negative hemodynamic event) between critically ill adults receiving sedation with ketamine and either propofol or dexmedetomidine."4.12Hemodynamic Effects of Ketamine Compared With Propofol or Dexmedetomidine as Continuous ICU Sedation. ( Atchley, E; Bauer, A; Benken, S; Meyer, R; Pulver, M; Tesoro, E, 2022)
"Anaesthesia with propofol is frequently associated with hypotension, which is at least partially attributable to increased nitric oxide (NO) formation derived from the activation of protein kinase C (PKC)/endothelial NO synthase (NOS3) axis."4.12Gene-gene interactions in the protein kinase C/endothelial nitric oxide synthase axis impact the hypotensive effects of propofol. ( Ferreira, GC; Garcia, LV; Lacchini, R; Luizon, MR; Oliveira-Paula, GH; Paula-Garcia, WN; Pereira, DA; Pinheiro, LC; Tanus-Santos, JE, 2022)
"The primary exposure was total propofol induction dose in mg/kg, and the primary outcome was occurrence of severe hypotension (MAP≤55 mmHg) prior to surgical incision, stratified by non-invasive vs."4.12Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65. ( Akhtar, S; Bardia, A; Burg, MM; Dai, F; Kheterpal, S; Mathis, M; Michel, G; Schonberger, RB; Shah, N; Vaughn, MT, 2022)
"Although the largest decrease in propofol dosage required for intubation was after IV premedication with acepromazine and butorphanol, hypotension and apnea still occurred."4.12Effects of intravenous acepromazine and butorphanol on propofol dosage for induction of anesthesia in healthy Beagle dogs. ( Dantino, SC; Kleine, SA; Seddighi, R; Smith, CK; Smith, SM; Zhu, X, 2022)
"Hypotension that is resistant to phenylephrine is a complication that occurs in anesthetized patients treated with angiotensin converting enzyme (ACE) inhibitors."4.12Blockade of endothelial Mas receptor restores the vasomotor response to phenylephrine in human resistance arterioles pretreated with captopril and exposed to propofol. ( Freed, JK; Hockenberry, JC; Katunaric, B; Pagel, PS; Schulz, ME, 2022)
"The development of hypotension on administration of intravenous propofol is common and independently associated with adverse outcomes."4.02Predicting hypotension during anesthesia: Variation in pulse oximetry plethysmography predicts propofol-induced hypotension in children. ( Choi, SN; Jang, YE; Ji, SH; Kim, EH; Kim, HS; Kim, JT; Lee, JH, 2021)
" This report describes a case of severe bradyarrhythmia during anesthetic induction with propofol, midazolam, sufentanil, and vecuronium."4.02Bradyarrhythmia and hypotension during anesthetic induction-reconsideration of nifedipine: a case report. ( Zhang, X, 2021)
" We hypothesised that anaesthesia-induced hypotension causes renal vasoconstriction and decreased oxygen delivery via angiotensin II-mediated renal vasoconstriction."3.96Pre-treatment with the angiotensin receptor 1 blocker losartan protects renal blood flow and oxygen delivery after propofol-induced hypotension in pigs. ( Franzén, S; Frithiof, R, 2020)
"To compare the development of clinically significant hemodynamic event (ie, hypotension or bradycardia) in adults with septic shock receiving either propofol or dexmedetomidine."3.96Effects From Continuous Infusions of Dexmedetomidine and Propofol on Hemodynamic Stability in Critically Ill Adult Patients With Septic Shock. ( Hammond, DA; Nelson, KM; Patel, GP, 2020)
"Propofol anesthesia is usually accompanied by hypotension."3.88Angiotensin converting enzyme inhibitors enhance the hypotensive effects of propofol by increasing nitric oxide production. ( Ferreira, GC; Garcia, LV; Garcia, WNP; Lacchini, R; Oliveira-Paula, GH; Pinheiro, LC; Tanus-Santos, JE, 2018)
"In early 2015, clinicians throughout Zambia noted a range of unpredictable adverse events after the administration of propofol, including urticaria, bronchospasm, profound hypotension, and most predictably an inadequate depth of anesthesia."3.85An Analysis of Substandard Propofol Detected in Use in Zambian Anesthesia. ( Attaran, A; Bould, MD; Curtis, S; Mayer, P; Mumphansha, H; Nickerson, JW; Overton, S, 2017)
"Hypotension is a common side effect of propofol, but there are no reliable methods to determine which patients are at risk for significant propofol-induced hypotension (PIH)."3.83Ultrasound measurement of inferior vena cava collapse predicts propofol-induced hypotension. ( Au, AK; Fields, JM; Ku, BS; Papanagnou, D; Shirazi, M; Steinberg, D; Thom, C, 2016)
"A multicenter, retrospective, propensity-matched pilot study was conducted comparing patients with sepsis or severe sepsis who received CIV propofol for sedation to those who did not."3.83Effects of propofol on vasopressor use in patients with sepsis and severe sepsis: A pilot study. ( Boucher, AN; Jones, GM; Kimmons, LA; Marler, J; Mohrien, K; Oliphant, CS; Vandigo, JE, 2016)
" The effects of isoflurane, propofol, apnea, and hypotension on lower extremity MEPs were studied."3.81Methodology of motor evoked potentials in a rabbit model. ( Bombien, R; Goodwin, E; Haji, F; Juan, V; Khoynezhad, A; Lapchak, PA; Rastegar, M; Waterford, SD, 2015)
"Hypotension was the most frequent anesthetic complication during procedure under propofol-based deep sedation, but this method was safe and effective under appropriate monitoring."3.81Age correlates with hypotension during propofol-based anesthesia for endoscopic retrograde cholangiopancreatography. ( Khoi, CS; Lin, TY; Lu, CW; Wang, HC; Wong, JJ, 2015)
" Univariate analyses were performed to determine risk factors associated with severe hypotension during sedation with propofol."3.80Predictors of severe hypotension in neurocritical care patients sedated with propofol. ( Doepker, BA; Elijovich, L; Erdman, MJ; Jones, GM; Kimmons, LA, 2014)
"Severe hypotension and bradycardia occur at similar prevalence in neurocritical care patients who receive dexmedetomidine or propofol."3.80A comparison of severe hemodynamic disturbances between dexmedetomidine and propofol for sedation in neurocritical care patients. ( Doepker, BA; Elijovich, L; Erdman, MJ; Gerlach, AT; Jones, GM; Phillips, GS, 2014)
" We report a case of profound hypotension after anesthesia induction with propofol in a patient who was treated with two 600 mg doses of rifampin for prophylaxis of infection before surgery."3.79Case report: profound hypotension after anesthetic induction with propofol in patients treated with rifampin. ( Ehrenfeld, JM; Jiang, Y; Mirzakhani, H; Nozari, A; Peterfreund, R; Rosow, C; Sandberg, W; Szabo, M; Walsh, JL; Wang, J, 2013)
"The mortality rates in the present study were extremely high; further hypotension and elevations in plasma pro-inflammatory and anti-inflammatory cytokine concentrations after endotoxin injection were not attenuated by mild hyperthermia between 39 °C and 40 °C, but they were attenuated by propofol with mild hyperthermia."3.78Effects of propofol with hyperthermia in a rat model of endotoxemic shock. ( Mukawa, C; Taniguchi, T, 2012)
"Propofol is commonly used to induce anesthesia but has been associated with some negative cardiovascular side effects, including negative inotropy, hypotension, and bradycardia."3.77The intravenous anesthetic propofol inhibits human L-type calcium channels by enhancing voltage-dependent inactivation. ( Elmslie, KS; Fassl, J; High, KM; Stephenson, ER; Yarotskyy, V, 2011)
"Higher doses of dexmedetomidine may result in higher incidence of hypotension, longer LOS, and increased concomitant analgesic, sedative, and antipsychotic use, requiring further evaluation in trauma patients."3.77Evaluation of dexmedetomidine: safety and clinical outcomes in critically ill trauma patients. ( Devabhakthuni, S; Kufera, JA; Pajoumand, M; Stein, DM; Watson, K; Williams, C, 2011)
"Although obesity was associated with an increased frequency of SRCs, propofol sedation can be used safely in obese patients undergoing AEPs when administered by trained professionals."3.77Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures. ( Azar, R; Cote, GA; Early, D; Edmundowicz, SA; Hall, M; Hovis, CE; Hovis, RM; Jonnalagadda, SS; Kushnir, V; Mullady, DK; Murad, F; Waldbaum, L; Wani, S, 2011)
" Propofol generally offered good intubating conditions, but we encountered severe problems with arterial hypotension."3.76Propofol as an induction agent for endotracheal intubation can cause significant arterial hypotension in preterm neonates. ( Eifinger, F; Huenseler, C; Kribs, A; Oberthuer, A; Roth, B; Welzing, L, 2010)
" Independent predictors of PIH were high BMI, high American Society of Anesthesiology status, propofol coinduction, baseline hypotension, age and preincision duration."3.76High BMI in children as a risk factor for intraoperative hypotension. ( Blum, J; Cowan, A; Kheterpal, S; Maclean, S; Nafiu, OO; Tremper, KK, 2010)
"The authors report a case of short-term high-dose propofol-related metabolic acidosis in a 3-year-old girl."3.74Early propofol infusion syndrome following cerebral angiographic embolization for giant aneurysm repair. Case report. ( Muhonen, MG; Nwagwu, CI; Westhout, FD, 2007)
"In two patients, pheochromocytoma resection was performed under propofol/fentanyl anesthesia, while bispectral index (BIS) monitoring and blood volume measurement using pulse spectrophotometry were done."3.73[Anesthetic management with propofol for pheochromocytoma resection under monitoring of bispectral index and blood volume]. ( Ishida, K; Matsumoto, M; Morimoto, Y; Orita, H; Sakabe, T; Tsuruta, S; Utada, K, 2006)
" The adverse event (AE) rate was 18% and included apnea (10%), inadequate sedation (3%), bradycardia (2%), desaturation (1%), hypotension (1%) and bag-valve-mask use (1%)."3.73Emergency department procedural sedation and analgesia: A Canadian Community Effectiveness and Safety Study (ACCESS). ( Mensour, M; Michaud, J; Pineau, R; Sahai, V, 2006)
" There had not been severe hypotension reported in the literature in consequence of inadvertent epidural thiopental administration."3.73Intravenous propofol precipitates the hypotension induced by inadvertent epidural thiopental injection. ( Chan, KH; Chang, WK; Chu, CC; Huang, SY; Wang, CC, 2006)
"During incomplete cerebral ischemia, the neuroprotective anesthetics sevoflurane and propofol suppressed cerebral increases in norepinephrine and glutamate concentrations."3.72The effect of sevoflurane and propofol on cerebral neurotransmitter concentrations during cerebral ischemia in rats. ( Blobner, M; Engelhard, K; Hoffman, WE; Kochs, E; Matthes, B; Werner, C, 2003)
"Propofol may cause hypotension and the mechanism is complex."3.69Propofol inhibits medullary pressor mechanisms in cats. ( Chai, CY; Chen, SY; Luk, HN; Wu, WC; Yang, CY, 1997)
" The objective of this study was to compare the safety and efficacy profiles of the remimazolam and propofol when combined with alfentanil for sedation during ERCP procedures."3.30A randomized, controlled clinical trial comparing remimazolam to propofol when combined with alfentanil for sedation during ERCP procedures. ( Chen, HR; Dong, SA; Guo, Y; Li, HX; Li, WZ; Liu, SS; Song, K; Wang, JH; Wu, LL; Wu, LN; Yu, JB; Zhang, L, 2023)
"Esketamine is an S (+) enantiomer of ketamine with greater potency and similar psychomimetic effects compared to racemic ketamine."3.30Safety and tolerability of esketamine in propofol based sedation for endoscopic variceal ligation with or without injection sclerotherapy: Randomized controlled trial. ( Chen, J; Chen, X; Chen, Y; Dan, L; Duan, G; Huang, H; Liu, R; Lyu, H; Wang, Q; Wang, T, 2023)
" The primary outcome was the incidence of intraoperative cardiopulmonary adverse events (a composite outcome of hypotension, bradycardia and hypoxemia)."3.30Cardiopulmonary Adverse Events of Remimazolam versus Propofol During Cervical Conization: A Randomized Controlled Trial. ( Huang, Z; Ma, L; Mu, X; Nie, H; Wang, L; Wang, Y; Zheng, Z, 2023)
"Remimazolam tosilate (RT) is a novel short-acting GABA (A) receptor agonist that has a rapid recovery from procedural sedation and can be fully reversed by flumazenil."3.30Efficacy and safety of remimazolam tosilate versus propofol in patients undergoing day surgery: a prospective randomized controlled trial. ( Huang, J; Liu, M; Luo, W; Miao, C; Sun, M; Wan, J; Xia, L; Xiong, W; Xu, P; Zhang, J; Zhang, X; Zhang, Z; Zhong, J, 2023)
" The aim of this study was to investigate the effects of remimazolam besylate combined with alfentanil in patients undergoing fiberoptic bronchoscopy with preserved spontaneous breathing."3.30Effectiveness of remimazolam besylate combined with alfentanil for fiberoptic bronchoscopy with preserved spontaneous breathing: a prospective, randomized, controlled clinical trial. ( Chen, ZJ; Li, JY; Wang, JF; Xu, L; Yu, L; Zhang, L, 2023)
"Reducing hypotension is crucial as hypotension is the most common side effect of spinal anesthesia, and in older patients with various comorbidities, it can lead to fatality."3.30Norepinephrine prevents hypotension in older patients under spinal anesthesia with intravenous propofol sedation: a randomized controlled trial. ( Cho, J; Kim, H; Kim, HJ; Kim, KS; Koh, WU; Lee, S; Park, SW; Ro, YJ, 2023)
" The occurrence and types of treatment-emergent adverse events were similar among the 3 arms, both with a severity of grade 1 or 2."3.11Efficacy and safety of HSK3486 for the induction and maintenance of general anesthesia in elective surgical patients: a multicenter, randomized, open-label, propofol-controlled phase 2 clinical trial. ( Deng, J; Guan, YJ; Guo, QL; Lin, ZM; Liu, J; Liu, YF; Ma, EL; Wang, DX; Wei, XC; Yang, MC; Yu, XD; Zeng, Y; Zheng, H, 2022)
"Remimazolam is an ultrashort-acting benzodiazepine that is potentially a practical option for procedural sedation in colonoscopy."3.11Discharge readiness after remimazolam versus propofol for colonoscopy: A randomised, double-blind trial. ( Chen, L; Fu, B; Guan, J; Liu, L; Yao, Y; Zheng, X, 2022)
"However, adverse events such as hypoxemia often occur clinically."3.11Effects of intravenous lidocaine on hypoxemia induced by propofol-based sedation for gastrointestinal endoscopy procedures: study protocol for a prospective, randomized, controlled trial. ( An, LX; Qi, XR; Sun, JY; Xue, FS; Zhang, K, 2022)
"Remimazolam is a novel ultra-short-acting benzodiazepine."3.11Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy. ( Chang, H; Liao, Q; Qing, W; Tong, J; Yu, R; Zhang, F, 2022)
"Remimazolam is a new type of benzodiazepine drug, with supposed advantages of rapid induction, rapid recovery, stable hemodynamics, and mild respiratory inhibition."3.01Effect of remimazolam induction on hemodynamics in patients undergoing valve replacement surgery: A randomized, double-blind, controlled trial. ( Chen, J; Chen, Y; He, F; Lai, T; Liu, T; Lu, Y; Xie, Y, 2021)
"Periintubation hypotension is associated with poor outcomes in the critically ill."2.90Ketamine/propofol admixture vs etomidate for intubation in the critically ill: KEEP PACE Randomized clinical trial. ( Bauer, PR; Brown, DR; Gajic, O; Gallo De Moraes, A; Hoskote, SS; Iyer, VN; Nicholson, WT; Oeckler, RA; Pickering, B; Schroeder, DR; Smischney, NJ, 2019)
"Postoperative respiratory depression was defined as rate <10/min, hypercapnia/hypercarbia-arterial CO2 tension >50 mmHg or SO2 <90 while hypotension was defined as a decrease of 20 % in mean blood pressure compared to initial values."2.82Propofol-ketamine combination: a choice with less complications and better hemodynamic stability compared to propofol? On a prospective study in a group of colonoscopy patients. ( Babayıgıt, M; Baykal Tutal, Z; Derelı, N; Gulec, H; Horasanlı, E; Inceoz, H; Kurtay, A, 2016)
" Propofol-based sedation is simple, easy to use, and effective, but is not without cardiovascular and respiratory adverse effects."2.82A randomized, controlled trial to compare the efficacy and safety profile of a dexmedetomidine-ketamine combination with a propofol-fentanyl combination for ERCP. ( Goyal, R; Hasnain, S; Mittal, S; Shreevastava, S, 2016)
"Hypotension was defined as systolic blood pressure (SBP) < 90 mmHg, MAP < 60 mmHg, or a reduction in either SBP or MAP > 20% from baseline values."2.82Prewarming neurosurgical patients to minimize hypotension on induction of anesthesia: a randomized trial. ( Darvall, J; Leslie, K; Vijayakumar, R, 2016)
"16."2.82Etomidate plus propofol versus propofol alone for sedation during gastroscopy: a randomized prospective clinical trial. ( Chen, LM; Chen, M; Gan, GS; Ji, M; Li, BX; Song, XY; Tao, J; Wu, MC; Zhang, S; Zhang, YH; Zhou, X, 2016)
"The primary outcome assessed was hypoxemia incidence."2.82Determination of the appropriate propofol infusion rate for outpatient upper gastrointestinal endoscopy-a randomized prospective study. ( Li, Q; Xiao, W; Zhou, H; Zhou, Q, 2016)
" Monitoring by means of the bispectral index (BIS) has shown its utility in reducing the use of drugs and their adverse events in general anesthesia, but evidence in prolonged sedation is insufficient."2.82Bispectral Index Monitoring Reduces the Dosage of Propofol and Adverse Events in Sedation for Endobronchial Ultrasound. ( Bello, S; Chacón, E; De Pablo, F; Júdez, D; Martínez Ubieto, J; Mincholé, E; Pascual, A; Quesada, N, 2016)
"Determine the best propofol pharmacokinetic model that meets patient requirements and is devoid of major haemodynamic side effects."2.80Comparison of the hemodynamic response to induction and intubation during a target-controlled infusion of propofol with 2 different pharmacokinetic models. A prospective ramdomized trial. ( Alonso Rodriguez, E; Asensio Merino, F; Castilla, MS; Ramos Luengo, A, 2015)
"To assess the effects of dexmedetomidine (Dex) on propofol dosage in target-controlled infusion (TCI) and hemodynamics in patients undergoing laparoscopic surgery under general anesthesia."2.80[Effects of dexmedetomidine on propofol dosage in target-controlled infusion and hemodynamics during laparoscopic surgery under general anesthesia]. ( Liang, FG; Ouyang, MW; Wang, HT, 2015)
"Propofol was administered by a target-controlled infusion system to attain and maintain a plasma propofol concentration of 1."2.79The effect of nitrous oxide inhalation on the hypotensive response to propofol: a randomized controlled trial. ( Boku, A; Hanamoto, H; Kudo, C; Morimoto, Y; Niwa, H; Sugimura, M; Yokoe, C, 2014)
"Propofol does not increase complications even in a collective with pre-existing impairment of LVEF."2.79Minimal and deep sedation during ablation of ventricular tachycardia. ( Attanasio, P; Blaschke, F; Boldt, LH; Haverkamp, W; Huemer, M; Loehr, L; Mueller, A; Parwani, AS; Storm, C; Wutzler, A, 2014)
"Propofol was infused at a dose determined by a modified Dixon's up-and-down method."2.79Intrathecal fentanyl decreases the optimal effect site concentration of propofol during spinal anaesthesia. ( Kim, JS; Kim, JY; Kim, MK; Kim, SH; Lee, JS, 2014)
" Additionally, propofol dosage and overall rate of adverse events in group Cs were lower than those in group Cc."2.78Stepwise sedation for elderly patients with mild/moderate COPD during upper gastrointestinal endoscopy. ( Cao, K; Chen, X; Guo, Q; Jia, Y; Liu, XM; Shen, SR; Tong, LL; Wang, F; Wang, XY; Xiao, DH; Xu, CX; Zou, HF, 2013)
"Propofol is a widely used anesthetic drug because of its minor complication and also its fast effect."2.77Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial. ( Ayatollahi, V; Behdad, S; Kargar, S; Yavari, T, 2012)
"Hypotension was treated with fluids and vasopressors using a standardised algorithm."2.76Effect of auditory evoked potential-guided anaesthesia on consumption of anaesthetics and early postoperative cognitive dysfunction: a randomised controlled trial. ( Berggren, L; Gupta, A; Hallén, JL; Jildenstål, PK; Rawal, N, 2011)
"Patients with liver cirrhosis frequently undergo diagnostic or therapeutic upper GI endoscopy (UGIE), and the liver disease might impair the metabolism of drugs usually administered for sedation."2.76Sedation during upper GI endoscopy in cirrhotic outpatients: a randomized, controlled trial comparing propofol and fentanyl with midazolam and fentanyl. ( Bonilha, DQ; Brito, JR; Correia, LM; Ferrari, AP; Gomes, GF; Lenz, L; Libera, ED; Nakao, FS; Rohr, MR, 2011)
"Propofol is a sedative-hypnotic with a rapid onset of action."2.76Feasibility and safety of propofol sedation in flexible bronchoscopy. ( Grendelmeier, P; Kurer, G; Pflimlin, E; Stolz, D; Tamm, M, 2011)
"The remifentanil consumption was much lower in group RP-E."2.74Hypotensive anesthesia with esmolol. Assessment of hemodynamics, consumption of anesthetic drugs, and recovery. ( Gökçe, BM; Karabiyik, L; Karadenizli, Y, 2009)
"Propofol was administered in a bolus of 1 mg/kg, followed by additional doses of 0."2.71Propofol for procedural sedation in children in the emergency department. ( Anderson, JL; Bassett, KE; Guenther, E; Pribble, CG, 2003)
"Patients receiving propofol reached full recovery sooner (16."2.71Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists. ( Chadalawada, V; Hansen, JJ; Liangpunsakul, S; Mendel, AM; Overley, CA; Rex, DK; Strahl, E; Symms, MR; Ulmer, BJ, 2003)
"Hypotension was documented in two patients in the propofol group and one patient receiving midazolam/meperidine."2.71Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study. ( Riphaus, A; Stergiou, N; Wehrmann, T, 2005)
"Ephedrine 0."2.69Prophylactic ephedrine attenuates the hemodynamic response to propofol in elderly female patients. ( Bentzon, MW; Helbo-Hansen, HS; Køhler, F; Lorenzen, AG; Michelsen, I; Rydlund, E, 1998)
"Glycopyrrolate was given to significantly more patients in group III (P < 0."2.68A comparison of propofol and isoflurane anaesthesia: the need for ephedrine and glycopyrrolate. ( Eintrei, C; Granfeldt, H; Jensen, AG; Kalman, SH; Nyström, PO, 1995)
" The results of this trial suggest that a propofol-based anesthetic, when compared to an enflurane-based anesthetic requiring additional dosing of fentanyl and midazolam for CPB, can lead to a significant reduction in time to extubation after CABG surgery, without adverse hemodynamic effects, increased risk of myocardial ischemia or infarction."2.68Hemodynamic effects, myocardial ischemia, and timing of tracheal extubation with propofol-based anesthesia for cardiac surgery. ( Buckland, MR; Bujor, MA; Davis, BB; Hunt, JO; Langley, M; McRae, R; Moloney, JT; Myles, PS; Weeks, AM, 1997)
"Propofol sedation has a similar risk of cardiopulmonary adverse events compared with traditional agents for gastrointestinal endoscopic procedures."2.55Similar Risk of Cardiopulmonary Adverse Events Between Propofol and Traditional Anesthesia for Gastrointestinal Endoscopy: A Systematic Review and Meta-analysis. ( Garg, S; Issa, D; Lopez, R; Sanaka, MR; Vargo, JJ; Wadhwa, V, 2017)
" Half concluded that propofol was sufficiently safe; three reviews noted a higher occurrence of adverse events, particularly respiratory depression (upper estimate 1."2.53What Works and What's Safe in Pediatric Emergency Procedural Sedation: An Overview of Reviews. ( Evered, L; Foisy, M; Hartling, L; Klassen, TP; Lang, ES; Milne, A; Sinclair, D, 2016)
"Propofol is a sedative-hypnotic that exerts its actions through agonism of GABAA receptors at a different binding site than benzodiazepines and reduces glutamatergic activity through N-methyl-d-aspartase (NMDA) receptor blockade."2.53Propofol for Treatment of Refractory Alcohol Withdrawal Syndrome: A Review of the Literature. ( Brotherton, AL; Hamilton, EP; Hammond, DA; Kloss, HG, 2016)
"Midazolam was associated with the deterioration of psychometric scores for a longer period than propofol."2.52Propofol versus midazolam for upper gastrointestinal endoscopy in cirrhotic patients: a meta-analysis of randomized controlled trials. ( Chen, CY; Chen, TL; Ko, CL; Lin, YC; Lou, HY; Tam, KW; Tsai, HC, 2015)
"Propofol is a potent intravenous anesthetic agent that rapidly induces sedation and unconsciousness."2.47Clinical effects and lethal and forensic aspects of propofol. ( Levy, RJ, 2011)
"Descriptive features of sedation including adverse events."2.42The safe and effective use of propofol sedation in children undergoing diagnostic and therapeutic procedures: experience in a pediatric ICU and a review of the literature. ( Ponaman, ML; Poss, BW; Vaux, KK; Wheeler, DS, 2003)
"Propofol is a short-acting intravenous anesthetic commonly utilised in the intensive care unit (ICU) for sedation of mechanically ventilated patients."2.40Propofol for sedation in the intensive care unit: essentials for the clinician. ( Marinella, MA, 1997)
"A 67-year-old woman with hypertension, type 2 diabetes mellitus, and hypothyroidism presented for an elective blepharoplasty."1.91A 67-Year-Old Woman With Fluctuating Hypertension and Hypotension After Elective Surgery. ( Ho, C; Lau, C, 2023)
" We examined here whether ARG1 and ARG2 genotypes and haplotypes affect the changes in blood pressure and NO bioavailability in response to propofol."1.62Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability. ( Coeli-Lacchini, FB; Ferezin, LP; Ferreira, GC; Garcia, LV; Lacchini, R; Oliveira-Paula, GH; Paula-Garcia, WN; Pinheiro, LC; Tanus-Santos, JE, 2021)
"Propofol is an intravenous anesthetic agent commonly used intraoperatively as well as in the intensive care unit."1.62Propofol-induced uric acid crystals: A case of cloudy urine. ( Baumgarten, A; Newton, M, 2021)
"Bradycardia was experienced by 11."1.56Use of Propofol Plus Dexmedetomidine in Patients Experiencing Severe Alcohol Withdrawal in the Intensive Care Unit. ( Love, K; Zimmermann, AE, 2020)
"Propofol was commonly used and is potentially associated with poorer clinical outcomes."1.56Comparison of drugs used for intubation of pediatric trauma patients. ( Davidson, J; Merritt, N; Mudri, M; Priestap, F; Williams, A, 2020)
"Hypotension was observed in 23 patients (4."1.56Propofol sedation with a target-controlled infusion pump in elderly patients undergoing ERCP. ( Akimoto, Y; Kato, H; Ogawa, T; Okada, H; Tanaka, S; Tomoda, T, 2020)
" Adverse effect profiles and clinical outcome, in the cohorts are largely similar."1.56DEXmedetomidine compared to PROpofol in NEurocritical Care [DEXPRONE]: A multicenter retrospective evaluation of clinical utility and safety. ( Armahizer, MJ; Heavner, MS; Kurczewski, L; Maciel, CB; Owusu, KA; Zichichi, A, 2020)
"Propofol-based sedation without endotracheal intubation is safe for ESD procedures in the esophagus and stomach with low anesthesia-related complication rates and short hospital stay."1.51Propofol sedation without endotracheal intubation is safe for endoscopic submucosal dissection in the esophagus and stomach. ( Bruno, MJ; Hilkemeijer, T; Klimek, M; Koch, AD; Leliveld, L; van de Ven, S, 2019)
" Adverse events in CAPS patients were recorded."1.51Computer-Assisted Propofol Sedation for Esophagogastroduodenoscopy Is Effective, Efficient, and Safe. ( Beecher, R; Chiorean, M; Drennan, F; Gluck, M; Koch, J; Kozarek, RA; La Selva, D; Larsen, M; Lin, OS; McCormick, S; Ross, A; Tombs, D; Venu, N; Weigel, W, 2019)
" Both propofol and dexmedetomidine proved to be adequate and safe medications in the sedation of autistic children undergoing MRI."1.48A Comparison of Safety and Efficacy of Dexmedetomidine and Propofol in Children with Autism and Autism Spectrum Disorders Undergoing Magnetic Resonance Imaging. ( Abulebda, K; Ahmed, SS; Louer, R; Lutfi, R, 2018)
"Single-center, retrospective review of trauma patients intubated in the emergency department."1.48Hemodynamic Effects of Propofol for Induction of Rapid Sequence Intubation in Traumatically Injured Patients. ( Delgado, SD; Dietrich, SK; Dunn, JA; Floren, M; Knapp, VE; Mixon, MA; Rogoszewski, RJ, 2018)
" Secondary end points included procedural success rates, polyp detection rates, adverse events, and procedure/recovery times."1.46The First US Clinical Experience With Computer-Assisted Propofol Sedation: A Retrospective Observational Comparative Study on Efficacy, Safety, Efficiency, and Endoscopist and Patient Satisfaction. ( Beecher, R; Gluck, M; Jensen, A; Kozarek, RA; La Selva, D; Lin, OS; Ross, A; Tombs, D; Weigel, W, 2017)
"Propofol Ce was simulated by inputting the propofol administration profiles of patients into a pediatric compartmental model (Choi model)."1.46A Simulation Study of Propofol Effect-Site Concentration for Appropriate Sedation in Pediatric Patients Undergoing Brain MRI: Pharmacodynamic Analysis. ( Byon, HJ; Han, DW; Jung, HH; Kim, SY; Na, SH; Song, Y, 2017)
"Hypotension was significantly more common among patients with COPD."1.46Flexible bronchoscopy with moderate sedation in COPD: a case-control study. ( Grendelmeier, P; Jahn, K; Pflimlin, E; Stolz, D; Tamm, M, 2017)
"Attention to hypoxemia is necessary in elderly patients, particularly patients with abnormal pulmonary function."1.43Propofol sedation with a target-controlled infusion pump and bispectral index monitoring system in elderly patients during a complex upper endoscopy procedure. ( Abe, M; Gotoda, T; Hori, K; Iwamuro, M; Kanzaki, H; Kawahara, Y; Kawano, S; Kita, M; Kono, Y; Miura, K; Okada, H; Yamamoto, K, 2016)
"Mild hypoxemia occurred in 24% of cases and resolved with nasal cannula."1.43Deep Sedation for Pediatric Dental Procedures: Is this a Safe and Effective Option? ( Ahmed, SS; Hicks, SR; Nitu, ME; Slaven, JE, 2016)
"Propofol cessation was necessary in 24 of 205 procedures."1.43Propofol sedation administered by cardiologists for patients undergoing catheter ablation for ventricular tachycardia. ( Höfeler, T; Hoffmann, BA; Lüker, J; Schäffer, B; Servatius, H; Steven, D; Sultan, A; Willems, S, 2016)
" We compared adverse event rates in MCI and TCI groups and assessed independent risk factors for adverse events."1.43Safety of Target-Controlled Propofol Infusion by Gastroenterologists in Patients Undergoing Endoscopic Resection. ( Jang, MK; Kang, SS; Kim, HS; Kim, HY; Lee, JS; Ryu, JY; Seo, SI; Shin, WG, 2016)
"For propofol, there was a significantly lower dosing for older patients: 17% for patients aged 65-79 and 29% for those aged >80, which was still in less than the recommendations."1.43Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice. ( Akhtar, S; Burg, MM; Dai, F; Heng, J; Liu, J; Schonberger, RB, 2016)
"Weight-adjusted anesthetic induction dosing, age-associated differences in dosing by ASA-PS (American Society of Anesthesiology-Physical Status), and hemodynamic outcomes between younger (18-64 years, n = 537) and older (≥65 years, n = 231) female patients were analyzed."1.43A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients? ( Akhtar, S; Burg, MM; Dai, F; Heng, J; Schonberger, RB, 2016)
"Propofol was the sole sedative used."1.40Same-day bidirectional endoscopy with nonanesthesiologist administration of propofol: safety and cost-effectiveness compared with separated exams. ( Angueira, T; Arias, Á; Chumillas, O; Fernández-Fuente, M; Fernández-Ordóñez, M; González-Castillo, S; Guagnozzi, D; Lucendo, AJ; Sánchez-Cazalilla, M; Serrano-Valverde, M; Tenías, JM, 2014)
"Cardiac arrhythmias were observed in 21 (53·8%) dogs."1.40Management and complications of anaesthesia during balloon valvuloplasty for pulmonic stenosis in dogs: 39 cases (2000 to 2012). ( Monteiro-Steagall, BP; Ramos, RV; Steagall, PV, 2014)
"Hypotension is more common in patients with Eisenmenger syndrome and similar physiology when a vasopressor is not used during the peri-induction period, regardless of induction agent."1.40Anesthetic management and outcomes for patients with pulmonary hypertension and intracardiac shunts and Eisenmenger syndrome: a review of institutional experience. ( Bennett, JM; Eagle, SS; Ehrenfeld, JM; Markham, L, 2014)
"Hypotension was defined when blood pressure decreased more than or equal to 25 percent compared to blood pressure measured at first in operating room."1.40[Retrospective evaluation of predictors and frequency of hypotension in hypertensive patients after induction of general anesthesia]. ( Ida, M; Iwata, M; Kamiya, T; Kimoto, K; Kuzumoto, N; Nakayama, K; Shimomura, T, 2014)
"Propofol was commenced in all patients at a mean infusion rate of 18."1.38Propofol sedation administered by cardiologists without assisted ventilation for long cardiac interventions: an assessment of 1000 consecutive patients undergoing atrial fibrillation ablation. ( Drewitz, I; Heitmann, K; Hoffmann, BA; Rostock, T; Salukhe, TV; Steven, D; Willems, S, 2012)
"Propofol is an intravenous anesthetic that is widely used to anesthetize patients during neurosurgical procedures."1.38Opioid receptor blockade prevents propofol-induced hypotension in rats. ( de Moura, RS; Lessa, MA; Maracajá-Neto, LF; Mello Silva, GA; Tibiriçá, E, 2012)
"Transient respiratory depression occurred in 13."1.38Induction dose of propofol for pediatric patients undergoing procedural sedation in the emergency department. ( Christich, AC; Edwards, CJ; Jasiak, KD; Patanwala, AE; Phan, H; Skrepnek, GH, 2012)
"Propofol was administered via intermittent i."1.38Endoscopist-administered propofol sedation is safe - a prospective evaluation of 10,000 patients in an outpatient practice. ( Friedrich, K; Sieg, A; Stremmel, W, 2012)
"Propofol was administered by continuous intravenous infusion to achieve deep sedation."1.37Safety of continuous propofol sedation for endoscopic procedures in elderly patients. ( Aparicio, JR; Casellas, JA; Compañy, L; Gómez-Escolar, L; Martínez, JF; Mozas, I; Ruiz, F, 2011)
"To provide data on the epidemiology of adverse events during sedation for endoscopy."1.37Adverse events during monitored anesthesia care for GI endoscopy: an 8-year experience. ( Agostoni, M; Beretta, L; Fanti, L; Gemma, M; Pasculli, N; Testoni, PA, 2011)
"78 cases of hypoxemia were documented in 1764 patients (4."1.37Nurse-administered propofol sedation for endoscopy: a risk analysis during an implementation phase. ( Banning, A; Bodtger, U; Hammering, A; Hornslet, P; Horsted, T; Jensen, JT; Vilmann, P, 2011)
"Propofol was given as monotherapy."1.37Nurse-administered propofol sedation for gastrointestinal endoscopic procedures: first Nordic results from implementation of a structured training program. ( Hammering, A; Hornslet, P; Mantoni, T; Slagelse, C; Vilmann, P, 2011)
"Where hypotension was present, the method of and response to treatment was recorded."1.36A comparison of anesthetic complications between diabetic and nondiabetic dogs undergoing phacoemulsification cataract surgery: a retrospective study. ( Clark, L; Corletto, F; Gould, DJ; Oliver, JA, 2010)
" We aimed to establish whether the duration of preoperative abstinence from fluids independently contributed to arterial blood pressure changes and dosage requirements during propofol induction."1.36The influence of duration of fluid abstinence on hypotension during propofol induction. ( Lewis, CM; Morley, AP; Nalla, BP; Natarajan, A; Prevost, AT; Strandvik, G; Vamadevan, S, 2010)
"Hypotension is a common occurrence during defibrillator implantation under conscious sedation."1.35Predictors of hemodynamic compromise with propofol during defibrillator implantation: a single center experience. ( Dhoble, A; Gardiner, JC; Habetler, T; Holliday, J; Janes, R; Natla, J; Pandya, K; Patel, MB; Punnam, SR; Thakur, RK, 2009)
"Propofol was administered using a standardized protocol, which included an initial dose of 0."1.34Efficacy, safety and patient satisfaction of propofol for procedural sedation and analgesia in the emergency department: a prospective study. ( Abu-Laban, RB; Chan, WW; Harrison, DW; Zed, PJ, 2007)
" Statistically significant multivariate predictors of hypotension 0-10 min after anesthetic induction included: ASA III-V, baseline MAP <70 mm Hg, age > or =50 yr, the use of propofol for induction of anesthesia, and increasing induction dosage of fentanyl."1.33Predictors of hypotension after induction of general anesthesia. ( Baez, B; Bernstein, A; Bodian, CA; Hossain, S; Krol, M; Patel, P; Reich, DL, 2005)
"Propofol was administered during PSA to 792 patients during the respective reporting period at each center."1.33Propofol for emergency department procedural sedation and analgesia: a tale of three centers. ( Becker, C; Burton, JH; Miner, JR; Shipley, ER; Strout, TD; Thode, HC, 2006)
"Propofol is an effective agent for use in procedural sedation and analgesia (PSA)."1.33Propofol by infusion protocol for ED procedural sedation. ( Bigelow, SK; Fay, K; Frank, LR; Hauff, SR; Strote, J, 2006)
"Propofol was delivered in intermittent boluses to achieve the desired level of anesthesia."1.31Prospective evaluation of propofol anesthesia in the pediatric intensive care unit for elective oncology procedures in ambulatory and hospitalized children. ( Anderson, BD; Dalton, HJ; Gootenberg, JE; Hauser, GJ; Hertzog, JH; Shad, AT, 2000)
"Nevertheless, severe hypoxemia is an accepted contraindication to FOB in nonintubated patients."1.31Bronchoscopy with bronchoalveolar lavage via the laryngeal mask airway in high-risk hypoxemic immunosuppressed patients. ( Cardinaud, JP; Favier, JC; Gbikpi-Benissan, G; Gruson, D; Hilbert, G; Portel, L; Valentino, R; Vargas, F, 2001)
"To determine the incidence of adverse events related to an endoscopy sedation regimen that included propofol, delivered by general practitioner (GP) sedationists."1.31Sedation for endoscopy: the safe use of propofol by general practitioner sedationists. ( Chiragakis, L; Clarke, AC; Hillman, LC; Kaye, GL, 2002)
"Propofol anesthesia was performed successfully in all children (mean age, 6."1.30Propofol anesthesia for invasive procedures in ambulatory and hospitalized children: experience in the pediatric intensive care unit. ( Campbell, JK; Dalton, HJ; Hauser, GJ; Hertzog, JH, 1999)
" However, marked tachycardia associated with the use of ephedrine in combination with propofol occurred in the majority of patients, occasionally reaching high levels in individual patients."1.30The haemodynamic effects of propofol in combination with ephedrine in elderly patients (ASA groups 3 and 4). ( Berridge, J; Freeman, J; Gamlin, F; Vucevic, M; Winslow, L, 1999)

Research

Studies (291)

TimeframeStudies, this research(%)All Research%
pre-19901 (0.34)18.7374
1990's28 (9.62)18.2507
2000's65 (22.34)29.6817
2010's128 (43.99)24.3611
2020's69 (23.71)2.80

Authors

AuthorsStudies
Yang, H1
Zhao, Q2
Chen, HY1
Liu, W2
Ding, T1
Yang, B1
Song, JC1
Aminnejad, R1
Hormati, A1
Shafiee, H1
Alemi, F1
Hormati, M1
Saeidi, M1
Ahmadpour, S1
Sabouri, SM1
Aghaali, M1
Atchley, E1
Tesoro, E1
Meyer, R1
Bauer, A1
Pulver, M1
Benken, S1
Gao, Y1
Yan, F1
Oliveira-Paula, GH3
Pereira, DA1
Pinheiro, LC3
Ferreira, GC3
Paula-Garcia, WN2
Garcia, LV3
Lacchini, R3
Luizon, MR1
Tanus-Santos, JE3
Sneyd, JR2
Absalom, AR1
Barends, CRM1
Jones, JB1
Cuniberti, B1
Huuskonen, V1
Hughes, JL1
Zeng, Y1
Wang, DX1
Lin, ZM1
Liu, J3
Wei, XC1
Deng, J1
Liu, YF1
Ma, EL1
Yang, MC1
Zheng, H1
Yu, XD1
Guo, QL1
Guan, YJ1
Hu, F1
Zou, L1
Chang, H3
Tian, L1
Liu, F1
Lan, Y1
Zhang, F3
Liu, X2
Schonberger, RB4
Dai, F3
Michel, G1
Vaughn, MT1
Burg, MM3
Mathis, M1
Kheterpal, S2
Akhtar, S4
Shah, N1
Bardia, A2
Yuan, I1
Xu, T1
Skowno, J1
Zhang, B1
Davidson, A1
von Ungern-Sternberg, BS1
Sommerfield, D1
Zhang, J5
Song, X1
Zhang, M1
Zhao, P3
Liu, H2
Jiang, Y2
Zuo, Y1
de Graaff, JC1
Vutskits, L1
Olbrecht, VA1
Szmuk, P1
Kurth, CD1
Dantino, SC1
Kleine, SA1
Smith, CK1
Smith, SM1
Zhu, X1
Seddighi, R1
Mandel, JE1
Zarfoss, EL1
Garavaglia, J1
Hayanga, JWA1
Kabulski, G1
Cao, Y1
Chi, P1
Zhou, C1
Lv, W1
Quan, Z1
Xue, FS2
Yao, Y1
Guan, J1
Liu, L2
Fu, B1
Chen, L1
Zheng, X1
Schulz, ME1
Hockenberry, JC1
Katunaric, B1
Pagel, PS1
Freed, JK1
Johnson, EG1
Weaver, SG1
Batt, KL1
Weaver, RH1
Schadler, A1
Hall, SJ1
Qi, XR1
Sun, JY1
An, LX1
Zhang, K2
Chen, J5
Zou, X1
Hu, B1
Yang, Y1
Wang, F2
Zhou, Q2
Shen, M1
Yokose, M1
Takaki, R1
Mihara, T1
Saigusa, Y1
Yamamoto, N1
Masui, K1
Goto, T1
Cairen, Z1
Shi, L1
Pang, S1
Shao, Y1
Wang, Y3
Lu, Z1
Lu, K1
Wei, S1
Ling, W1
Wei, Y1
Ran, X1
Huang, H2
Wang, M1
Wei, N1
Liao, Y1
Qin, Z1
Pan, M1
Wei, Q1
Fu, L1
Xiong, B1
Ma, C2
Jiang, J1
Huang, Y1
De Vico, P3
Cammalleri, V3
Marchei, M3
Macrini, M3
Lecis, D3
Idone, G3
Massaro, G3
Di Landro, A3
Zingaro, A3
Di Luozzo, M3
Prandi, FR3
Ussia, GP3
Romeo, F3
Dauri, M3
Muscoli, S3
Qing, W2
Yu, R2
Liao, Q2
Tong, J2
Wang, LL2
Guan, ZY2
Wang, CM2
Zhang, YW2
Sekiguchi, R1
Kinoshita, M1
Kawanishi, R1
Kakuta, N1
Sakai, Y1
Tanaka, K1
Lau, C1
Ho, C1
Dong, SA1
Guo, Y1
Liu, SS1
Wu, LL1
Wu, LN1
Song, K1
Wang, JH1
Chen, HR1
Li, WZ1
Li, HX1
Zhang, L2
Yu, JB1
Chen, Y2
Wang, Q1
Lyu, H1
Chen, X2
Liu, R1
Wang, T1
Dan, L1
Duan, G2
Lan, H1
Shan, W1
Wu, Y1
Xu, Q1
Dong, X1
Mei, P1
You, M1
Jin, L1
Wu, J2
Wu, X1
Wang, C1
Gao, H1
Bai, X1
Zhang, Z2
Chen, R1
Huang, X1
An, L1
Yi, J1
Tong, R1
Amin, SM1
Hasanin, A2
ElSayed, OS1
Mostafa, M2
Khaled, D1
Arafa, AS1
Hassan, A1
Fukuda, N1
Katakawa, M1
Ito, H2
Hara, T1
Otsuka, N1
Ishizuka, M1
Abe, M2
Wang, L2
Ma, L1
Mu, X1
Huang, Z1
Zheng, Z1
Nie, H1
Luo, W1
Sun, M1
Wan, J1
Huang, J1
Xiong, W1
Xia, L1
Xu, P1
Miao, C1
Zhang, X2
Liu, M1
Zhong, J1
Sjøen, GH1
Falk, RS1
Hauge, TH1
Tønnessen, TI1
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Khoo, ST1
Hug, CC1
McLeskey, CH1
Nahrwold, ML1
Roizen, MF1
Stanley, TH1
Thisted, RA1
Walawander, CA1
White, PF1
Apfelbaum, JL1
Grasela, TH1
Werner, ME1
Bach, DE1
Newhouse, RF1
Gamlin, F2
Vucevic, M2
Winslow, L2
Berridge, J2
el-Beheiry, H1
Kim, J1
Milne, B1
Seegobin, R1
Minami, K1
Yanagihara, N1
Segawa, K1
Tsutsui, M1
Shigematsu, A1
Izumi, F1
Gin, T1
Myles, PS1
Buckland, MR1
Weeks, AM1
Bujor, MA1
McRae, R1
Langley, M1
Moloney, JT1
Hunt, JO1
Davis, BB1
Yang, CY1
Luk, HN1
Chen, SY1
Wu, WC1
Chai, CY1
Andrews, DT1
Bjorksten, AR1
Marinella, MA1
Michelsen, I1
Helbo-Hansen, HS1
Køhler, F1
Lorenzen, AG1
Rydlund, E1
Bentzon, MW1
Stecker, MM1
Kramer, TH1
Raps, EC1
O'Meeghan, R1
Dulaney, E1
Skaar, DJ1
Ludbrook, GL1
Upton, RN1
Grant, C1
Martinez, A1
Hans, P1
Coussaert, E1
Cantraine, F1
Dewandre, PY1
Brichant, JF1
Grevesse, M1
Lamy, M1
Turner, RJ1
Gatt, SP1
Kam, PC1
Ramzan, I1
Daley, M1
Sánchez-Guerrero, IM1
Tortosa, JA1
Hernández-Palazón, J1
Escudero, AI1
Susla, GM1
Kasaba, T2
Kondou, O1
Yoshimura, Y2
Watanabe, Y1
Takasaki, M2
Hertzog, JH2
Campbell, JK1
Dalton, HJ2
Hauser, GJ2
Freeman, J1
Endoh, H1
Honda, T1
Komura, N1
Shibue, C1
Watanabe, I1
Shimoji, K1
Yamaga, M1
Iwasaki, T1
Riu, PL1
Riu, G1
Testa, C1
Mulas, M1
Caria, MA1
Mameli, S1
Mameli, O1
Anderson, BD1
Shad, AT1
Gootenberg, JE1
Redondo, JI1
Gómez-Villamandos, RJ1
Domínguez, JM1
Santisteban, JM1
Haberer, JP1
Hilbert, G1
Gruson, D1
Vargas, F1
Valentino, R1
Favier, JC1
Portel, L1
Gbikpi-Benissan, G1
Cardinaud, JP1
Chiu, CL1
Tew, GP1
Wang, CY1
Felfernig-Boehm, D1
Salat, A1
Kinstner, C1
Fleck, T1
Felfernig, M1
Kimberger, O1
Andel, H1
Mueller, MR1
Muchada, R1
Lucchesie, G1
Clarke, AC1
Chiragakis, L1
Hillman, LC1
Kaye, GL1
Meersschaert, K1
Brun, L1
Gourdin, M1
Mouren, S1
Bertrand, M1
Riou, B1
Coriat, P1
Kamijo, Y1
Goto, H1
Nakazawa, K1
Benson, KT1
Arakawa, K1
Muzi, M1
Berens, RA1
Kampine, JP1
Ebert, TJ1
Mayall, R1
Mackay, JH1
Walker, IA1
Bethune, DW1
White, DA1
Smyth, DG1
Moseley, H1
Shankar, KB1
Kumar, Y1
Hallsworth, R1
Krishnan, A1

Clinical Trials (72)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of Esketamine-Propofol and Fentanyl-Propofol on Haemodynamics in Elderly Patients[NCT05752409]120 participants (Anticipated)Interventional2021-10-08Recruiting
The Study of Ciprofol for the Suppression of Cardiovascular Responses to Tracheal[NCT06095570]Phase 4150 participants (Anticipated)Interventional2022-07-23Recruiting
The Investigation of the Dose Range of Remimazolam Besylate in Different Age Groups of Adults and Its Effects on Hemodynamics[NCT06009991]1,876 participants (Anticipated)Interventional2023-07-17Recruiting
The Impact of Electroencephalogram (EEG) - Guided Inhalational Anesthetic Control on the Occurrence of EEG Discontinuity in Infants: A Prospective Randomized Controlled Trial[NCT05906225]78 participants (Anticipated)Interventional2023-06-20Not yet recruiting
EEG to Monitor Propofol Anesthetic Depth in Infants and Toddlers[NCT05701748]120 participants (Anticipated)Interventional2023-02-03Recruiting
Does Intravenous Lidocaine Reduce Propofol Consumption and the Side Effects of Sedation During Gastroscopy in ASA 1 and 2 Patients.[NCT05944887]46 participants (Actual)Interventional2023-07-21Completed
Efficacy of Oxycodone-propofol Combination Compared With a Fentanyl-propofol Combination on Conscious Sedation Effect and Early Cognitive Function During Therapeutic Endoscopic Retrograde Cholangio-pancreatography:a Prospective,Randomized, Single- Blinded[NCT03755609]100 participants (Anticipated)Interventional2018-06-01Recruiting
[NCT02442232]65 participants (Actual)Observational2015-08-31Completed
Effect of General Anesthesia With Remimazolam Versus Propofol on Postoperative Delirium in Elderly Patients[NCT06180876]190 participants (Anticipated)Interventional2022-05-25Recruiting
Effects of Propofol Titration at Different Speeds on Hemodynamics and Stress During General Anesthesia Induction[NCT04595591]276 participants (Actual)Interventional2020-10-23Completed
Observational Study to Evaluate the Pressure Recording Analytical Method Parameters in Patients Susceptible to Post-induction Hypotension Due to Hypertension, Diabetes Mellitus, Cardiovascular Risk Factors, or Major Surgery[NCT05960604]660 participants (Anticipated)Observational2023-12-25Not yet recruiting
Different Types of Intraoperative Hypotension and Their Association With Post-anesthesia Care Unit Recovery[NCT05671783]4,776 participants (Actual)Observational2022-05-06Completed
Effect of Propofol on Postoperative Nausea and Vomiting in Patients Undergoing Elective Cesarean Section Under Spinal Anesthesia.[NCT05071794]Phase 460 participants (Actual)Interventional2021-05-01Completed
A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05327296]Phase 3235 participants (Anticipated)Interventional2022-06-30Recruiting
A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05312385]Phase 3235 participants (Anticipated)Interventional2022-04-28Recruiting
Early Goal-Directed Sedation Compared With Standard Care in Mechanically Ventilated Critically Ill Patients: a Prospective Multicentre Randomised Controlled Trial[NCT01728558]Phase 34,000 participants (Actual)Interventional2013-11-30Completed
Efficacy and Safety of Remimazolam for Sedation in ICU Patients Undergoing Mechanical Ventilation: a Single Center, Randomized, Controlled, Non-inferiority Trial[NCT04815265]Phase 4488 participants (Anticipated)Interventional2021-04-01Not yet recruiting
"Ketamine / Propofol Admixture Ketofol at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial"[NCT02105415]Phase 2/Phase 3160 participants (Actual)Interventional2014-04-30Completed
Capnography Monitoring the Hypoventilation During Bronchoscopic Sedation[NCT02848118]124 participants (Actual)Interventional2015-01-31Completed
Dexmedetomidine and Brain Perfusion Monitor for Sedation of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration[NCT03521505]Phase 450 participants (Actual)Interventional2018-05-11Completed
Target-Controlled Infusion of Propofol for Flexible Bronchoscopy Sedation: Determining the Optimal Titrating Regimen[NCT01101477]144 participants (Actual)Interventional2010-02-28Terminated (stopped due to Hypoxemia(SPaO2<80%) episodes occured significantly in the arm titration by 0.5ug/ml)
Dexmedetomidine vs Propofol TIVA and Interscalene Block for Shoulder Surgeries in a Beach Chair Sitting Position[NCT02469961]Phase 450 participants (Actual)Interventional2010-10-31Completed
The Optimal Sequence in Same-day Bidirectional Endoscopy Under Deep Anesthesia Induced by Propofol Combined With Fentanyl: A Prospective Randomized Controlled ,Two Centers Trial[NCT04973878]544 participants (Anticipated)Interventional2021-07-30Not yet recruiting
Risk Factors of Delirium in Sequential Sedation Patients in Intensive Care Unit[NCT03194360]141 participants (Actual)Observational2015-12-01Completed
Preoperative Dexmedetomidine Reduces the EC50 of Propofol for Successful i-gelTM Insertion Without Muscle Relaxants[NCT02097407]Phase 437 participants (Actual)Interventional2012-05-31Completed
Hemodynamic Responses During Induction: Comparison of Marsh and Schnider Pharmacokinetic Models in Propofol Plasma Target-controlled Infusion[NCT01759160]60 participants (Actual)Interventional2012-12-31Completed
A Randomized, Controlled Trial to Compare the Efficacy and Safety Profile of a Remimazolam-alfentanil Combination With a Propofol-alfentanil Combination for ERCP[NCT04658173]1,000 participants (Anticipated)Interventional2020-12-22Recruiting
Respiratory Effect of the LISA (Less Invasive Surfactant Administration) Method With Sedation by Propofol Versus Absence of Sedation: Double-blind Comparative Randomized Clinical Trial.[NCT04016246]Phase 3542 participants (Anticipated)Interventional2019-10-07Recruiting
The Use of Sedation Drugs in the Procedure of Administering Surfactant Without Intubation (LISA/MIST): a Randomized Study Comparing Intravenous Ketamine With Sublingual 30% Glucose[NCT04409665]Phase 160 participants (Anticipated)Interventional2020-01-01Recruiting
Dexmedetomidine for LISA Procedure in Preterm Infants: a Pilot Study[NCT04820101]40 participants (Anticipated)Interventional2021-05-15Not yet recruiting
Propofol Sedation During Endoscopic Retrograde Cholangiopancreatography: A Comparison Between Conventional Versus Bispectral Index Guided Approach and Effect of Diclofenac Sodium Along With Topical Pharyngeal Anaesthesia[NCT04860167]90 participants (Actual)Interventional2018-09-10Completed
Safety and Efficacy Evaluation of Remimazolam for Endoscopic Ultrasound-guided Fine Needle Aspiration/Biopsy[NCT05437497]264 participants (Anticipated)Interventional2021-08-01Recruiting
Cardiac Autonomic Dysfunction and Perioperative Outcomes After Neurosurgery[NCT05230641]400 participants (Actual)Observational2022-03-01Completed
Correlation Between Perioperative Autonomic Function and Adverse Events Such as Post-induction Hypotension in Elderly Patients[NCT05425147]180 participants (Anticipated)Observational2022-06-11Recruiting
Cerebral Blood Flow During Propofol Anaesthesia[NCT02951273]30 participants (Actual)Observational2016-12-08Completed
The Effect of Phenylephrine Versus Ephedrine on Cerebral Perfusion During Carotid Endarterectomy[NCT01451294]40 participants (Anticipated)Interventional2011-11-30Not yet recruiting
Influence of Vasopressors on Brain Oxygenation and Microcirculation in Anesthetized Patients With Cerebral Tumors[NCT02713087]Phase 448 participants (Actual)Interventional2015-09-30Completed
Comparison of Intubation Conditions After Induction With Propofol Associated With a Dose of Remifentanil or Sufentanil in Surgical Tooth Extraction.[NCT01910285]Phase 470 participants (Actual)Interventional2013-06-30Completed
Evaluation of the Changes of Pleth Variability Index During Preoxygenation for Predicting Hypotension During Induction of Anesthesia in Surgical Patients; Prospective Observational Study[NCT04991220]96 participants (Anticipated)Interventional2021-08-30Not yet recruiting
Evaluation of Perfusion Index-derived Parameters as Predictors of Hypotension After Induction of General Anaesthesia: a Prospective Cohort Study.[NCT04217226]93 participants (Actual)Observational2020-01-20Completed
Comparison of Ultrasound-based Measures of Inferior Vena Cava and Plethysmographic Variability Index for Prediction of Hypotension During Induction of General Anesthesia; Prospective Cohort Study.[NCT04238234]90 participants (Anticipated)Observational2021-08-05Recruiting
Focussed Echocardiography to Detect Preoperative Hypovolemia and Left Ventricular Dysfunction as a Predictor of Post-Induction Hypotension[NCT02944266]150 participants (Anticipated)Observational2016-01-31Recruiting
Predictability of Hemodynamic Instability With Increase in Perfusion Index (PI) and Pleth Variability Index (PVI) Values After Spinal Block in Elective Cesarean Sections[NCT05174260]113 participants (Actual)Observational [Patient Registry]2021-12-02Completed
An Observer Rating Scale of Facial Expression Can Predict Dreaming in Propofol Anesthesia[NCT04235894]124 participants (Actual)Observational2016-09-07Completed
Dexmedetomidine Compared to Midazolam for Symptom Control in Advanced Cancer Patients: A Pilot Randomized Controlled Trial (RCT)[NCT01687751]Phase 20 participants (Actual)Interventional2012-11-30Withdrawn (stopped due to Study design determined to be not likely feasible)
Ciprofol vs Propofol for Reducing Hypoxia Incidence in Intravenous Anesthesia During Elective Endoscopic Retrograde Cholangiopancreatography-A Randomized Double Blinded Controlled Trial.[NCT06015074]124 participants (Anticipated)Interventional2023-10-01Not yet recruiting
Nasal Inhalation of Sevoflurane Versus Midazolm,Ketamine and Propofol For Pediatric Undergoing Upper Gastrointestinal Endoscopy[NCT05474937]74 participants (Anticipated)Interventional2022-06-01Recruiting
Nurse Administered Propofol Sedation vs. Standard Therapy for Colonoscopy in Patients With IBD. A Randomised Controlled Study on Satisfaction and Adherence to Treatment Program.[NCT01934088]Phase 4130 participants (Actual)Interventional2014-01-31Completed
High Flow Nasal Cannula (HFNC) Versus Standard Low Flow Nasal Cannula (LFNC) in Patients With Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation (RFCA) Under Deep Desaturation.[NCT04842253]210 participants (Anticipated)Interventional2022-01-04Recruiting
A Pilot Study to Investigate the Efficacy and Safety of Dexmedetomidine and Fentanyl Versus Midazolam and Remifentanil for Sedation in Patients Undergoing Ablation Procedures for Treatment of a Tachyarrhythmia[NCT03451227]6 participants (Actual)Interventional2017-12-01Terminated (stopped due to Unable to recruit eligible participants)
Use of Non-Invasive Positive Pressure Ventilation in Patients With Severe Obesity Undergoing Upper Endoscopy Procedures[NCT03529461]56 participants (Actual)Interventional2017-04-25Completed
Bispectral Index Monitoring for Sedation in Elective Colonoscopies of Adult Patients: a Randomized Controlled Trial[NCT03453359]180 participants (Actual)Interventional2018-01-28Completed
Comparison of Leg Elevation and Leg Wrapping in the Prevention of Propofol Induced Hypotension: A Prospective Randomised Controlled Study[NCT02845921]150 participants (Anticipated)Interventional2016-01-31Recruiting
Comparison of the Effects of Total Intravenous Anesthesia and Inhalation Anesthesia on Lymphocytes in Patients Undergoing Colorectal Cancer Resection and the Mechanism Involved: a Single-center, Randomized, Prospective Study[NCT03193710]260 participants (Anticipated)Observational2017-09-01Recruiting
Goal Directed Propofol Sedation With Magnesium Sulphate Versus Dexmedetomidine for ERCP Procedure[NCT02684019]Phase 360 participants (Actual)Interventional2016-01-31Completed
[NCT00848861]92 participants (Actual)Interventional2006-02-28Completed
Comparison of Ketamine-propofol Sedation Protocols With Fentanyl-propofol Administered by Endoscopist or Anesthesiologist at Colonoscopy[NCT03607110]120 participants (Actual)Observational2018-03-01Completed
Effect of Dexmedetomidine of Gastrointestinal Motility[NCT04798482]Phase 422 participants (Actual)Interventional2021-09-14Completed
[NCT02039453]160 participants (Anticipated)Interventional2013-09-30Recruiting
Comparative Study Between Intravenous Nalbuphine Versus Intravenous Dexmedetomidine for Conscious Sedation in Patients Undergoing Colonoscopy[NCT05689242]Phase 466 participants (Anticipated)Interventional2023-03-31Not yet recruiting
"Haemodynamic Stability During Induction of General Anesthesia With Propofol and Remifentanil: A Randomized, Controlled, Double-blind Study Comparing Equipotent Prophylactic Doses of Ephedrine, Phenylephrine, Norepinephrine vs Placebo."[NCT03864094]Phase 499 participants (Anticipated)Interventional2022-03-15Recruiting
Fentanyl Effect on Blood Pressure in Elderly Patients After Induction of General Anesthesia[NCT02489019]Phase 2/Phase 3105 participants (Anticipated)Interventional2018-02-19Recruiting
Perfusion Index as a Predictor of Hypotension Following Propofol Induction of General Anesthesia in Geriatric Patients - A Prospective Observational Study.[NCT04682717]30 participants (Actual)Observational2020-12-01Completed
Effect of the Pneumatic Compression of Lower Leg on Post-induction Hypotension in Elderly Patients Undergoing Robot Assisted Laparoscopic Prostatectomy: a Double Blined Randomized Controlled Trial[NCT05343689]100 participants (Actual)Interventional2022-05-04Completed
"PGDT With the Hypotension Prediction Index to Reduce the Number and Duration of Intraoperative Hypotension and the Incidence of Renal Failure in Patients Undergoing Lung Surgery"[NCT04149314]142 participants (Actual)Interventional2019-11-20Completed
Incidence of Sedation Related Complications With Propofol Alone Versus Propofol With Benzodiazepines and Opiates in a High Risk Group Undergoing Advanced Endoscopic Procedures: A Randomized Controlled Trial[NCT01315158]36 participants (Actual)Interventional2011-01-31Terminated (stopped due to - The research team is not able to obtain the necessary support to continue the study.)
A Psychomotor Recuperation Study After Deep Sedation for Colonoscopy Between Target Controlled and Manual Titration of Propofol.[NCT02314559]Phase 4164 participants (Actual)Interventional2015-02-28Completed
Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial[NCT01269307]99 participants (Actual)Interventional2010-06-30Completed
Phase II Study, Randomized, Monocentric, Single-blind, Comparing the Efficacy of Xenon and Desflurane, in Association With a Thoracic Epidural Analgesia in the Maintenance Phase of a Colorectal Oncologic Surgery[NCT01696630]Phase 231 participants (Actual)Interventional2012-10-31Completed
Safety and Efficacy of Propofol Only Sedation in Oral and Maxillofacial Surgery[NCT01227174]Phase 4169 participants (Anticipated)Interventional2011-01-31Not yet recruiting
Effect of Ringer Lactate Preloading on Induction Dose Requirement of Propofol and Its Haemodynamic Stability at a Tertiary Center[NCT05777135]Phase 460 participants (Anticipated)Interventional2023-04-01Recruiting
Comparison of Three Different Pain and Anxiety Reducing Methods in Adult Patients Undergoing Bone Marrow Puncture[NCT00188227]Phase 4748 participants Interventional2001-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Intensive Care Unit Free Days

comparison of intensive care unit free days between the two groups (NCT02105415)
Timeframe: hospital discharge or day 28, whichever comes first

Interventiondays (Median)
Etomidate16
Ketamine / Propofol Admixture17

Mechanical Ventilation Free Days

comparison of mechanical ventilation free days between the two groups (NCT02105415)
Timeframe: hospital discharge or day 28, whichever comes first

Interventiondays (Median)
Etomidate22
Ketamine / Propofol Admixture20

Mortality

In-hospital/28 day mortality among patients in ketamine/propofol combination compared to in-hospital/28-day mortality in etomidate. (NCT02105415)
Timeframe: Hospital Discharge or Day 28, whichever comes first

InterventionParticipants (Count of Participants)
Etomidate26
Ketamine / Propofol Admixture25

Number of Participants Experiencing Delirium Using Confusion Assessment Method in ICU

Comparison of number of participants who were positive for delirium using CAM-ICU between groups (NCT02105415)
Timeframe: up to 24 hours post study drug administration

InterventionParticipants (Count of Participants)
Etomidate7
Ketamine / Propofol Admixture4

Number of Participants With Adrenal Insufficiency

Incidence of adrenal insufficiency between ketamine/propofol admixture and etomidate. Adrenal insuffiency was evaluated with co-syntropin stimulation test. (NCT02105415)
Timeframe: up to 24 hours post study drug administration

InterventionParticipants (Count of Participants)
Etomidate (3-5 Hours)13
Ketamine/Propofol Admixture (3-5 Hours)5
Etomidate (23-25 Hours)9
Ketamine/Propofol Admixture (23-25 Hours)6

Blood Product Transfusions

blood product transfusions [Red Blood Cells vs. non-Red Blood Cells] between the two groups (NCT02105415)
Timeframe: hospital discharge or day 28, whichever comes first

,
InterventionParticipants (Count of Participants)
Red blood cellNon-red blood cellColloid
Etomidate211628
Ketamine / Propofol Admixture13826

Mean Arterial Pressure

Mean arterial pressure for the ketamine/propofol group at a 1:1 dose ratio compared to the etomidate group within the first 15 minutes post-administration in patients in need of urgent and/or emergent endotracheal intubation, as defined by any intubation within the intensive care unit excluding intubations for elective procedural events and codes. (NCT02105415)
Timeframe: baseline and every 5 minutes up to 15 minutes minutes post study drug administration

,
Interventionmm Hg (Mean)
Baseline5 minutes10 minutes15 minutes
Etomidate82.881.781.979.1
Ketamine / Propofol Admixture80.977.675.375.5

Vasopressor Use

The use of vasoactive medications to restore the blood pressure post-administration in the ketamine/propofol combination as compared to the etomidate group. (NCT02105415)
Timeframe: up to 24 hours post study drug administration

,
InterventionParticipants (Count of Participants)
Pre-treamentNew-onset pressors (within 3 minutes)Delayed-onset pressors (within 24 hours)
Etomidate11257
Ketamine / Propofol Admixture51864

Bradycardia During Bronchoscopic Sedation

The percentage of patients with bradycardia (heat beat per minute less than 60) (NCT03521505)
Timeframe: After starting sedation, up to 120 minutes.

InterventionParticipants (Count of Participants)
Dexmedetomidine Arm12
Propofol Arm4

Hypotension During Bronchoscopic Sedation

The percentage of patients with hypotension (mean arterial blood pressure (MAP) less than 65 mmHg with any duration. (NCT03521505)
Timeframe: After starting sedation, up to 120 minutes.

InterventionParticipants (Count of Participants)
Dexmedetomidine Arm1
Propofol Arm5

Hypoxemia During Induction

The percentage of patients with hypoxemia (oxyhemoglobin saturation (SpO2)<90%) during induction of bronchoscopic sedation (NCT03521505)
Timeframe: After starting induction, up to 30 minutes.

InterventionParticipants (Count of Participants)
Dexmedetomidine Arm1
Propofol Arm2

Hypoxemia During Maintenance

The percentage of patients with hypoxemia (oxyhemoglobin saturation (SpO2)<90%) during maintenance of Bronchoscopic sedation (NCT03521505)
Timeframe: After starting bronchoscopy, up to 120 minutes

InterventionParticipants (Count of Participants)
Dexmedetomidine Arm8
Propofol Arm14

Procedure Time and Recovery Time

The procedure time of bronchoscopy and recovery time from sedation to awake. (NCT03521505)
Timeframe: After starting bronchoscopy, up to 120 minutes.

Interventionminutes (Mean)
Dexmedetomidine Arm30.0
Propofol Arm27.6

The Cooperation of Patients From the View of Bronchoscopists

The Cooperation of Patients will be evaluated by 100-mm visual analogue scale (VAS, 0: well cooperation, 100: worst cooperation) after recovery. (NCT03521505)
Timeframe: After recovery from sedation, up to 120 minutes

Interventionunits on a scale (Median)
Dexmedetomidine Arm14
Propofol Arm31

The Global Tolerance for Bronchoscopy

The Global Tolerance of patients for bronchoscopy will be evaluated by 100-mm visual analogue scale (VAS, 0: no bother, 100: worst intolerable) after recovery (NCT03521505)
Timeframe: After recovery from sedation, up to 120 minutes

Interventionunits on a scale (Median)
Dexmedetomidine Arm12.5
Propofol Arm0

The Number of Patients With Hypoxemia During Flexible Bronchoscopy

"Hypoxemia is defined as:~Oxyhemoglobin saturation (SPO2) is less than 90 % with any duration" (NCT01101477)
Timeframe: During sedative induction and bronchoscopy

Interventionparticipants (Number)
Titration by Target Effect Site Concentration (Cet) 0.5μg/ml29
Titration by Cet 0.2μg/ml22
Titration by Cet 0.1μg/ml18

Number of Participants That Have Either Bradycardia or Hypotension

Number of participants observed with Bradycardia or Hypotension who required intervention (NCT02469961)
Timeframe: Participants will be followed from the start of sedation until discharge: approximately 3-5 hr

Interventionparticipants (Number)
Propofol4
Dexmedetomidine5

Number of Participants That Need an Airway Intervention.

airway manipulation or repositioning: apnea, oral airway, adjust head (NCT02469961)
Timeframe: Participants will be followed from the start of sedation until discharge: approximately 3-5 hr

Interventionparticipants (Number)
Dexmedetomidine0
Propofol5

Post Anesthesia Care Unit (PACU) Length of Stay

length of stay in minutes in the Post Anesthesia Care Unit before discharge (NCT02469961)
Timeframe: Arrival in the PACU until discharge either to home or to a hospital in-patient bed approximately 1-3 hr after the operation

InterventionMinutes (Mean)
Dexmedetomidine159
Propofol126

Total Narcotic Used by Each Participant

the use for morphine and/or fentanyl and or Demerol converted to morphine equivalents (NCT02469961)
Timeframe: Participants will be followed from the start of sedation until discharge: approximately 3-5 hr

InterventionMicrogram (Mean)
Dexmedetomidine7.1
Propofol9

SVI (Stroke Volume Index) Value Change From Baseline Level at the End of the First 25 Minutes.

After propofol infusion started, according to sedation level, TCI targets were gradually titrated to reach a state of equilibrium at the end of the first 25 minutes. SVI were continuously monitored, at the end of the first 25 minutes, value change from baseline level were calculated. (NCT01759160)
Timeframe: The end of the first 25 minutes after propofol infusion

Interventionml/beat/m^2 (Mean)
Marsh-31.1
Schnider-31.7

Association by Multiple Regression Between Changes in Internal Carotid Artery Blood Flow, Mean Arterial Pressure and Cardiac Output by Treatment of Anaesthesia-induced Hypotension.

"Association by multiple regression between changes in unilateral internal carotid artery blood flow [ml/min] as outcome variable and changes in mean arterial pressure [mmHg] and cardiac output [l/min] as covariates.~Internal carotid artery blood flow [ml/min] was assessed by duplex ultrasound. Mean arterial pressure [mmHg] was recorded by a transducer connected to an arterial line. Cardiac output [l/min] was evaluated by pulse contour analysis (Modelflow) that estimates cardiac output by analysis of the arterial pressure curve taking age, gender, height and weigth into account." (NCT02951273)
Timeframe: Two measurements; one measurement during anaesthesia-induced hypotension (mean arterial pressure < 65 mmHg) before administration of phenylephrine and one measurement 3-5 min after administration of phenylephrine.

Interventionml/min (Least Squares Mean)
Study of Cerebral Blood Flow376

Changes in Cardiac Output From Baseline Before Induction of Anaesthesia.

Cardiac output [l/min] as evaluated continuously by pulse contour analysis of the arterial pressure curve (Modelflow). (NCT02951273)
Timeframe: Continuous measurements from before induction of anaesthesia and until 2 hours after start of surgery.

Interventionl/min (Mean)
Study of Cerebral Blood Flow-2.7

Changes in Forehead Skin Blood Flow by Development of Mesenteric Traction Syndrome (MTS).

Forehead skin blood flow [PU] assessed by laser Doppler flowmetry as compared between those patients who develop mesenteric traction syndrome (defined as flushing within 60 min after the start of surgery) and those who do not. Laser Doppler flowmetry applies a laser placed on the forehead that penetrates the skin and is scattered with a Doppler shift by the red blood cells and return to a detector that evaluates the amount of backscattered light and Doppler shift. An effect of a MTS was evaluated by a repeated measure mixed model with the fixed effects time point, group according to development of MTS, and interaction between time and group. The reported result is the interaction factor for the time point 0 min after flushing and 20 min after the start of surgery in patients who did not develop MTS. (NCT02951273)
Timeframe: Six measurements during anaesthesia; 5 min before and after incision and 0, 20, 40, and 70 min after flushing and 20, 40, 60, and 90 min after the start of surgery in those patients who do not develop mesenteric traction syndrome.

InterventionPU (Mean)
Study of Cerebral Blood Flow126

Changes in Forehead Skin Oxygenation by Development of Mesenteric Traction Syndrome (MTS).

Forehead skin oxygenation [%] assessed by laser Doppler flowmetry as compared between those patients who develop a MTS (defined as flushing within 60 min after the start of surgery) and those who do not. An effect of a MTS was evaluated by a repeated measure mixed model with the fixed effects time point, group according to development of MTS, and interaction between time and group. The reported result is the interaction factor for the time point 0 min after flushing and 20 min after the start of surgery in patients who did not develop MTS. (NCT02951273)
Timeframe: Six measurements during anaesthesia; 5 min before and after incision and 0, 20, 40, and 70 min after flushing and 20, 40, 60, and 90 min after the start of surgery in those patients who do not develop mesenteric traction syndrome.

Interventionoxygenation [%] (Mean)
Study of Cerebral Blood Flow-2

Changes in Frontal Lobe Oxygenation by Development of Mesenteric Traction Syndrome (MTS).

Near-infrared spectroscopy determined frontal lobe oxygenation [%] as compared between those patients who develop a MTS (defined as flushing within 60 min after the start of surgery) and those who do not. An effect of a MTS was evaluated by a repeated measure mixed model with the fixed effects time point, group according to development of MTS, and interaction between time and group. The reported result is the interaction factor for the time point 0 min after flushing and 20 min after the start of surgery in patients who did not develop MTS. (NCT02951273)
Timeframe: Six measurements during anaesthesia; 5 min before and after incision and 0, 20, 40, and 70 min after flushing and 20, 40, 60, and 90 min after the start of surgery in those patients who do not develop mesenteric traction syndrome.

Interventionoxygenation [%] (Mean)
Study of Cerebral Blood Flow2

Changes in Heart Rate From Baseline Before Induction of Anaesthesia.

Heart rate [bpm] as recorded continuously by a transducer connected to an arterial line. (NCT02951273)
Timeframe: Continuous measurements from before induction of anaesthesia and until 2 hours after start of surgery.

Interventionbeats/min (Mean)
Study of Cerebral Blood Flow-13

Changes in Internal Carotid Artery Blood Flow by Development of Mesenteric Traction Syndrome (MTS).

Unilateral internal carotid artery blood flow [ml/min] assessed by duplex ultrasound as compared between those patients who develop a MTS (defined as flushing within 60 min after the start of surgery) and those who do not. An effect of a MTS was evaluated by a repeated measure mixed model with the fixed effects time point, group according to development of MTS, and interaction between time and group. The reported result is the interaction factor for the time point 0 min after flushing and 20 min after the start of surgery in patients who did not develop MTS. (NCT02951273)
Timeframe: Six measurements during anaesthesia; 5 min before and after incision and 0, 20, 40, and 70 min after flushing and 20, 40, 60, and 90 min after the start of surgery in those patients who do not develop mesenteric traction syndrome.

Interventionml/min (Mean)
Study of Cerebral Blood Flow-3

Changes in Internal Carotid Artery Blood Flow by Induction of Anaesthesia.

Unilateral internal carotid artery blood flow [ml/min] assessed by duplex ultrasound. (NCT02951273)
Timeframe: Two measurements; one measurement 5-10 min before induction of anaesthesia and one measurement 5-20 min after induction of anaesthesia.

Interventionml/min (Mean)
Study of Cerebral Blood Flow-144

Changes in Internal Carotid Artery Blood Flow by Treatment of Anaesthesia-induced Hypotension

Unilateral internal carotid artery blood flow [ml/min] assessed by duplex ultrasound. (NCT02951273)
Timeframe: Two measurements; one measurement during anaesthesia-induced hypotension (mean arterial pressure < 65 mmHg) before administration of phenylephrine and one measurement 3-5 min after administration of phenylephrine.

Interventionml/min (Mean)
Study of Cerebral Blood Flow27

Changes in Mean Arterial Pressure From Baseline Before Induction of Anaesthesia.

Mean arterial pressure [mmHg] as recorded continuously by a transducer connected to an arterial line. (NCT02951273)
Timeframe: Continuous measurements from before induction of anaesthesia and until 2 hours after start of surgery.

InterventionmmHg (Mean)
Study of Cerebral Blood Flow-41

Changes in Stroke Volume From Baseline Before Induction of Anaesthesia.

Stroke volume [ml] as evaluated continuously by pulse contour analysis of the arterial pressure curve (Modelflow). (NCT02951273)
Timeframe: Continuous measurements from before induction of anaesthesia and until 2 hours after start of surgery.

Interventionml (Mean)
Study of Cerebral Blood Flow-24

Changes in the CO2 Reactivity of the Internal Carotid Artery From Before to After Induction of Anaesthesia.

"Unilateral internal carotid artery blood flow [ml/min] assessed by duplex ultrasound and arterial CO2 tension (PaCO2) [kPa] was evaluated by gas analysis. Changes in PaCO2 are guided by evaluation of end-tidal CO2 tension.~The CO2 reactivity to hypocapnia when awake and during anaesthesia is calculated as the percentage change in internal carotid artery blood flow per kPa change in PaCO2. The CO2 reactivity when awake and when anaesthetized is compared." (NCT02951273)
Timeframe: Four measurements; before induction of anaesthesia during normoventilation and during hyperventilation to reduce PaCO2 by 1.5 kPa and during anaesthesia at a PaCO2 at the value before induction of anaesthesia and 1.5 kPa below that value.

Intervention%/kPa (Mean)
Study of Cerebral Blood Flow7.4

Percentage of Participants in the Control Group With an Oxygen Saturation Less Than 90 % Who Responded to Rescue NIPPV

We used non-invasive positive pressure ventilation (NIPPV) as a first rescue maneuver in control patients who developed an oxygen desaturation less than 90 % and reported on the percentage of participants who responded. The rescue was considered successful with recovery of oxygen saturation more than 90 % within 3 minutes. (NCT03529461)
Timeframe: 3 minutes following a desaturation event < 90 %

InterventionParticipants (Count of Participants)
Control Participants With Oxygen Desaturation < 90%8

Percentage of Participants With an Oxygen Desaturation Event < 90%

Percentage of participants who develop a peripheral oxygen saturation event < 90%. (NCT03529461)
Timeframe: Time in seconds beginning with the start of procedure (anesthesia induction) ending with procedure completion (eyes open to verbal stimuli).

Interventionpercentage of participants (Number)
Control28.6
Experimental3.5

Percentage of Participants With an Oxygen Desaturation Event ≤ 94%

Percentage of participants who develop a peripheral oxygen saturation measured by pulse oximetry ≤ 94% (NCT03529461)
Timeframe: Time in seconds beginning with the start of procedure (anesthesia induction) ending with procedure completion (eyes open to verbal stimuli).

Interventionpercentage of participants (Number)
Control57.1
Experimental14.3

Number of Participants Who Experience Airway Maneuvers

In high risk patients (meeting at least of 1 of 3 criteria: ASA ≥ 3, BMI ≥ 30, those at risk for OSA) undergoing advanced endoscopy procedures, compare the number of participants who experience airway maneuvers (AMs) when sedated with propofol alone versus propofol in combination with benzodiazepines and opioids. (NCT01315158)
Timeframe: One day (during procedure)

Interventionparticipants (Number)
Propofol+Benzo/Opioids4
Propofol Alone4

Number of Participants Who Experience Other Sedation Related Complications

Compare the number of participants who experience other sedation related complications such as hypotension, hypoxemia and need for termination of the procedure between the two groups (NCT01315158)
Timeframe: One day (during procedure)

Interventionparticipants (Number)
Propofol+Benzo/Opioids0
Propofol Alone0

Number of Participants Who Experience Symptoms of Nausea and Vomiting Will be Compared Between the Two Groups

The number of participants who experience symptoms of nausea and vomiting in the two groups of patients will be recorded. This will be recorded during the follow-up phone call made 24-48 hours after the procedure. (NCT01315158)
Timeframe: 24-48 hours

Interventionparticipants (Number)
Propofol+Benzo/Opioids2
Propofol Alone1

Predictors of Sedation Related Complications as Measured by Early Procedure Termination for an Alternative Sedation Related Complication

(NCT01315158)
Timeframe: One year

Interventionincidences (Number)
Propofol+Benzo/Opioids0
Propofol Alone0

Predictors of Sedation Related Complications as Measured by Hypopnea/Apnea (Defined as Fewer Than 6 Breaths/Minute Based on Capnography)

(NCT01315158)
Timeframe: One year

Interventionincidences (Number)
Propofol+Benzo/Opioids0
Propofol Alone0

Predictors of Sedation Related Complications as Measured by the Incidences of Hypotension (Defined as Systolic Blood Pressure of Less Than 90mmHg or a Decrease of More Than 25% From Baseline)

(NCT01315158)
Timeframe: One year

Interventionincidences (Number)
Propofol+Benzo/Opioids0
Propofol Alone0

Predictors of Sedation Related Complications as Measured by the Number of Participants Who Experience Hypoxemia (Defined as a Pulse Oximetry <90% for Any Duration)

(NCT01315158)
Timeframe: One year

Interventionparticipants (Number)
Propofol+Benzo/Opioids0
Propofol Alone0

Reviews

23 reviews available for propofol and Hypotension

ArticleYear
Hypotension during propofol sedation for colonoscopy: a retrospective exploratory analysis and meta-analysis.
    British journal of anaesthesia, 2022, Volume: 128, Issue:4

    Topics: Colonoscopy; Humans; Hypnotics and Sedatives; Hypotension; Midazolam; Propofol; Retrospective Studie

2022
Hypotension during propofol sedation for colonoscopy: a retrospective exploratory analysis and meta-analysis.
    British journal of anaesthesia, 2022, Volume: 128, Issue:4

    Topics: Colonoscopy; Humans; Hypnotics and Sedatives; Hypotension; Midazolam; Propofol; Retrospective Studie

2022
Hypotension during propofol sedation for colonoscopy: a retrospective exploratory analysis and meta-analysis.
    British journal of anaesthesia, 2022, Volume: 128, Issue:4

    Topics: Colonoscopy; Humans; Hypnotics and Sedatives; Hypotension; Midazolam; Propofol; Retrospective Studie

2022
Hypotension during propofol sedation for colonoscopy: a retrospective exploratory analysis and meta-analysis.
    British journal of anaesthesia, 2022, Volume: 128, Issue:4

    Topics: Colonoscopy; Humans; Hypnotics and Sedatives; Hypotension; Midazolam; Propofol; Retrospective Studie

2022
Remimazolam versus propofol for procedural sedation and anesthesia: a systemic review and meta-analysis.
    Minerva anestesiologica, 2022, Volume: 88, Issue:12

    Topics: Anesthesia, General; Benzodiazepines; Humans; Hypnotics and Sedatives; Hypotension; Propofol

2022
Comparison of remimazolam and propofol about safety outcome indicators during general anesthesia in surgical patients: a systematic review and meta-analysis.
    Minerva anestesiologica, 2023, Volume: 89, Issue:6

    Topics: Anesthesia, General; Benzodiazepines; Dizziness; Humans; Hypnotics and Sedatives; Hypotension; Hypox

2023
Remimazolam
    PeerJ, 2023, Volume: 11

    Topics: Anesthesia; Benzodiazepines; Bradycardia; Conscious Sedation; Dizziness; Humans; Hypotension; Pain;

2023
Safety and efficacy of propofol alone or in combination with other agents for sedation of patients undergoing colonoscopy: an updated meta-analysis.
    European review for medical and pharmacological sciences, 2020, Volume: 24, Issue:8

    Topics: Apnea; Colonoscopy; Deep Sedation; Drug Therapy, Combination; Humans; Hypnotics and Sedatives; Hypot

2020
Comparison of clinical efficacy and safety between dexmedetomidine and propofol among patients undergoing gastrointestinal endoscopy: a meta-analysis.
    The Journal of international medical research, 2021, Volume: 49, Issue:7

    Topics: Dexmedetomidine; Endoscopy, Gastrointestinal; Humans; Hypnotics and Sedatives; Hypotension; Propofol

2021
Comparison of bolus versus continuous infusion of propofol for procedural sedation: a meta-analysis.
    Current medical research and opinion, 2017, Volume: 33, Issue:11

    Topics: Anesthesia; Humans; Hypnotics and Sedatives; Hypotension; Propofol; Randomized Controlled Trials as

2017
Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.
    The Cochrane database of systematic reviews, 2018, 08-21, Volume: 8

    Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave

2018
Moderate and deep sedation training and pharmacology for nonanesthesiologists: recommendations for effective practice.
    Current opinion in anaesthesiology, 2019, Volume: 32, Issue:4

    Topics: Administration, Intravenous; Analgesics, Opioid; Anesthesiology; Apnea; Benzodiazepines; Conscious S

2019
Propofol versus midazolam for upper gastrointestinal endoscopy in cirrhotic patients: a meta-analysis of randomized controlled trials.
    PloS one, 2015, Volume: 10, Issue:2

    Topics: Anesthesia Recovery Period; Bradycardia; Deep Sedation; Endoscopy, Gastrointestinal; Fibrosis; Hepat

2015
Anaesthetic and sedative agents used for electrical cardioversion.
    The Cochrane database of systematic reviews, 2015, Mar-22, Issue:3

    Topics: Anesthetics; Apnea; Diazepam; Electric Countershock; Etomidate; Fentanyl; Humans; Hypnotics and Seda

2015
What Works and What's Safe in Pediatric Emergency Procedural Sedation: An Overview of Reviews.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2016, Volume: 23, Issue:5

    Topics: Anesthetics, Intravenous; Child; Conscious Sedation; Female; Humans; Hypnotics and Sedatives; Hypote

2016
Propofol for Treatment of Refractory Alcohol Withdrawal Syndrome: A Review of the Literature.
    Pharmacotherapy, 2016, Volume: 36, Issue:4

    Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Alcohol-Induced Disorders, Nervous System; Bradycardia;

2016
Similar Risk of Cardiopulmonary Adverse Events Between Propofol and Traditional Anesthesia for Gastrointestinal Endoscopy: A Systematic Review and Meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2017, Volume: 15, Issue:2

    Topics: Anesthesia; Anesthetics, Intravenous; Arrhythmias, Cardiac; Endoscopy, Gastrointestinal; Humans; Hyp

2017
The Comparison of Etomidate and Propofol Anesthesia in Patients Undergoing Gastrointestinal Endoscopy: A Systematic Review and Meta-Analysis.
    Surgical laparoscopy, endoscopy & percutaneous techniques, 2017, Volume: 27, Issue:1

    Topics: Anesthesia Recovery Period; Anesthetics, Intravenous; Apnea; Arterial Pressure; Colonoscopy; Endosco

2017
Propofol infusion syndrome: a rare complication with potentially fatal results.
    Critical care nurse, 2008, Volume: 28, Issue:3

    Topics: Acidosis; Acute Kidney Injury; Adult; Anesthetics, Intravenous; Arrhythmias, Cardiac; Critical Care;

2008
Clinical effects and lethal and forensic aspects of propofol.
    Journal of forensic sciences, 2011, Volume: 56 Suppl 1

    Topics: Accidents; Acidosis; Acute Kidney Injury; Bacteremia; Bradycardia; Drug Overdose; Dyslipidemias; For

2011
The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Adult; Aged; Anesthesia, Intravenous; Apnea; Arrhythmias, Cardiac; Endoscopy, Gastrointestinal; Huma

2013
The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Adult; Aged; Anesthesia, Intravenous; Apnea; Arrhythmias, Cardiac; Endoscopy, Gastrointestinal; Huma

2013
The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Adult; Aged; Anesthesia, Intravenous; Apnea; Arrhythmias, Cardiac; Endoscopy, Gastrointestinal; Huma

2013
The use of propofol as a sedative agent in gastrointestinal endoscopy: a meta-analysis.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Adult; Aged; Anesthesia, Intravenous; Apnea; Arrhythmias, Cardiac; Endoscopy, Gastrointestinal; Huma

2013
The safe and effective use of propofol sedation in children undergoing diagnostic and therapeutic procedures: experience in a pediatric ICU and a review of the literature.
    Pediatric emergency care, 2003, Volume: 19, Issue:6

    Topics: Child; Diagnosis; Humans; Hypnotics and Sedatives; Hypotension; Intensive Care Units, Pediatric; Len

2003
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005
Reports of death with use of propofol (Diprivan) for nonprocedural (long-term) sedation and literature review.
    Anesthesiology, 2006, Volume: 105, Issue:5

    Topics: Acidosis; Adult; Adverse Drug Reaction Reporting Systems; Cardiovascular System; Child; Humans; Hypn

2006
Propofol for sedation in the intensive care unit: essentials for the clinician.
    Respiratory medicine, 1997, Volume: 91, Issue:9

    Topics: Adult; Aged; Apnea; Bradycardia; Critical Care; Drug Administration Schedule; Half-Life; Humans; Hyp

1997
Propofol toxicity in critically ill pediatric patients: show us the proof.
    Critical care medicine, 1998, Volume: 26, Issue:12

    Topics: Acidosis, Lactic; Anesthetics, Intravenous; Bradycardia; Child; Child, Preschool; Conscious Sedation

1998

Trials

127 trials available for propofol and Hypotension

ArticleYear
The median effective concentration of propofol with different doses of esketamine during gastrointestinal endoscopy in elderly patients: A randomized controlled trial.
    British journal of clinical pharmacology, 2022, Volume: 88, Issue:3

    Topics: Aged; Anesthetics, Intravenous; Endoscopy, Gastrointestinal; Humans; Hypnotics and Sedatives; Hypote

2022
Comparing the Efficacy and Safety of Dexmedetomidine/Ketamine with Propofol/Fentanyl for Sedation in Colonoscopy Patients: A Doubleblinded Randomized Clinical Trial.
    CNS & neurological disorders drug targets, 2022, Volume: 21, Issue:8

    Topics: Apnea; Colonoscopy; Dexmedetomidine; Double-Blind Method; Fentanyl; Humans; Hypnotics and Sedatives;

2022
Comparison of Intra and Post-operative Sedation Efficacy of Dexmedetomidinemidazolam and Dexmedetomidine-propofol for Major Abdominal Surgery.
    Current drug metabolism, 2022, Volume: 23, Issue:1

    Topics: Anesthesia; Apnea; Dexmedetomidine; Humans; Hypertension; Hypnotics and Sedatives; Hypotension; Hypo

2022
Comparison between continuous rate infusion and target-controlled infusion of propofol in dogs: a randomized clinical trial.
    Veterinary anaesthesia and analgesia, 2023, Volume: 50, Issue:1

    Topics: Anesthetics, Intravenous; Animals; Apnea; Dog Diseases; Dogs; Hypotension; Propofol; Prospective Stu

2023
Efficacy and safety of HSK3486 for the induction and maintenance of general anesthesia in elective surgical patients: a multicenter, randomized, open-label, propofol-controlled phase 2 clinical trial.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:4

    Topics: Anesthesia, General; Anesthetics, Intravenous; Elective Surgical Procedures; Humans; Hypotension; Pr

2022
Remimazolam Tosilate Sedation with Adjuvant Sufentanil in Chinese Patients with Liver Cirrhosis Undergoing Gastroscopy: A Randomized Controlled Study.
    Medical science monitor : international medical journal of experimental and clinical research, 2022, Jun-16, Volume: 28

    Topics: Benzodiazepines; China; Gastroscopy; Humans; Hypnotics and Sedatives; Hypotension; Liver Cirrhosis;

2022
Discharge readiness after remimazolam versus propofol for colonoscopy: A randomised, double-blind trial.
    European journal of anaesthesiology, 2022, 12-01, Volume: 39, Issue:12

    Topics: Adult; Benzodiazepines; Bradycardia; Colonoscopy; Humans; Hypnotics and Sedatives; Hypotension; Mida

2022
Effects of intravenous lidocaine on hypoxemia induced by propofol-based sedation for gastrointestinal endoscopy procedures: study protocol for a prospective, randomized, controlled trial.
    Trials, 2022, Sep-24, Volume: 23, Issue:1

    Topics: Conscious Sedation; Endoscopy, Gastrointestinal; Humans; Hypotension; Hypoxia; Lidocaine; Midazolam;

2022
Effect of different doses of esketamine compared with fentanyl combined with propofol on hypotension in patients undergoing painless abortion surgery: a prospective, randomized, double-blind controlled clinical trial.
    BMC anesthesiology, 2022, 09-28, Volume: 22, Issue:1

    Topics: Analgesics; Anesthetics, Intravenous; Double-Blind Method; Female; Fentanyl; Humans; Hypotension; Ke

2022
Hypotension after general anesthesia induction using remimazolam in geriatric patients: Protocol for a double-blind randomized controlled trial.
    PloS one, 2022, Volume: 17, Issue:9

    Topics: Aged; Anesthesia, General; Benzodiazepines; Double-Blind Method; Humans; Hypnotics and Sedatives; Hy

2022
Remimazolam versus propofol for deep sedation/anaesthesia in upper gastrointestinal endoscopy in elderly patients: A multicenter, randomized controlled trial.
    Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:12

    Topics: Aged; Anesthesia; Benzodiazepines; Bradycardia; Deep Sedation; Endoscopy, Gastrointestinal; Female;

2022
Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy.
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Benzodiazepines; Dizziness; Female; Humans; Hypnotics and Sedatives; Hypotension; Hysteroscopy; Naus

2022
Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy.
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Benzodiazepines; Dizziness; Female; Humans; Hypnotics and Sedatives; Hypotension; Hysteroscopy; Naus

2022
Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy.
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Benzodiazepines; Dizziness; Female; Humans; Hypnotics and Sedatives; Hypotension; Hysteroscopy; Naus

2022
Remimazolam Tosylate Combined with Low-Dose Propofol Improves Sedation and Safety in Hysteroscopy.
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Benzodiazepines; Dizziness; Female; Humans; Hypnotics and Sedatives; Hypotension; Hysteroscopy; Naus

2022
A comparative study on the efficacy and safety of propofol combined with different doses of alfentanil in gastroscopy: a randomized controlled trial.
    Journal of anesthesia, 2023, Volume: 37, Issue:2

    Topics: Alfentanil; Anesthetics, Intravenous; Bradycardia; Dizziness; Gastroscopy; Humans; Hypotension; Hypo

2023
A comparative study on the efficacy and safety of propofol combined with different doses of alfentanil in gastroscopy: a randomized controlled trial.
    Journal of anesthesia, 2023, Volume: 37, Issue:2

    Topics: Alfentanil; Anesthetics, Intravenous; Bradycardia; Dizziness; Gastroscopy; Humans; Hypotension; Hypo

2023
A comparative study on the efficacy and safety of propofol combined with different doses of alfentanil in gastroscopy: a randomized controlled trial.
    Journal of anesthesia, 2023, Volume: 37, Issue:2

    Topics: Alfentanil; Anesthetics, Intravenous; Bradycardia; Dizziness; Gastroscopy; Humans; Hypotension; Hypo

2023
A comparative study on the efficacy and safety of propofol combined with different doses of alfentanil in gastroscopy: a randomized controlled trial.
    Journal of anesthesia, 2023, Volume: 37, Issue:2

    Topics: Alfentanil; Anesthetics, Intravenous; Bradycardia; Dizziness; Gastroscopy; Humans; Hypotension; Hypo

2023
Comparison of hemodynamics during induction of general anesthesia with remimazolam and target-controlled propofol in middle-aged and elderly patients: a single-center, randomized, controlled trial.
    BMC anesthesiology, 2023, 01-10, Volume: 23, Issue:1

    Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Hemodynamics; Humans; Hypotension; Middl

2023
A randomized, controlled clinical trial comparing remimazolam to propofol when combined with alfentanil for sedation during ERCP procedures.
    Journal of clinical anesthesia, 2023, Volume: 86

    Topics: Alfentanil; Cholangiopancreatography, Endoscopic Retrograde; Conscious Sedation; Humans; Hypnotics a

2023
Safety and tolerability of esketamine in propofol based sedation for endoscopic variceal ligation with or without injection sclerotherapy: Randomized controlled trial.
    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 2023, Volume: 35, Issue:7

    Topics: Humans; Hypotension; Ketamine; Propofol; Sclerotherapy

2023
Clinical effect of different doses of ciprofol for induction of general anesthesia in elderly patients: A randomized, controlled trial.
    Pharmacology research & perspectives, 2023, Volume: 11, Issue:2

    Topics: Aged; Anesthesia, General; Anesthetics, Intravenous; Humans; Hypotension; Propofol; Receptors, GABA-

2023
Comparison of the hemodynamic effects of opioid-based versus lidocaine-based induction of anesthesia with propofol in older adults: a randomized controlled trial.
    Anaesthesia, critical care & pain medicine, 2023, Volume: 42, Issue:4

    Topics: Aged; Analgesics, Opioid; Anesthesia, General; Anesthetics, Intravenous; Emergence Delirium; Fentany

2023
Cardiopulmonary Adverse Events of Remimazolam versus Propofol During Cervical Conization: A Randomized Controlled Trial.
    Drug design, development and therapy, 2023, Volume: 17

    Topics: Alfentanil; Anesthetics, Intravenous; Benzodiazepines; Bradycardia; Conization; Humans; Hypotension;

2023
Efficacy and safety of remimazolam tosilate versus propofol in patients undergoing day surgery: a prospective randomized controlled trial.
    BMC anesthesiology, 2023, 05-26, Volume: 23, Issue:1

    Topics: Ambulatory Surgical Procedures; Flumazenil; Humans; Hypotension; Pain; Propofol; Prospective Studies

2023
Hemodynamic effects of a low versus a high dose of propofol during induction of anesthesia. A randomized trial.
    Acta anaesthesiologica Scandinavica, 2023, Volume: 67, Issue:9

    Topics: Anesthesia, General; Anesthetics, Intravenous; Female; Hemodynamics; Humans; Hypotension; Propofol;

2023
Post-induction hypotension with remimazolam versus propofol in patients routinely administered angiotensin axis blockades: a randomized control trial.
    BMC anesthesiology, 2023, 06-22, Volume: 23, Issue:1

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Angiotensins; Benzodiazepines; Female; Humans

2023
Efficacy of Isoflurane-Remifentanil versus Propofol-Remifentanil on Controlled Hypotension and Surgeon Satisfaction in Rhinoplasty: A Single-Blind Clinical Trial Study.
    Iranian journal of medical sciences, 2023, Volume: 48, Issue:4

    Topics: Anesthetics, Intravenous; Child; Humans; Hypotension; Hypotension, Controlled; Isoflurane; Personal

2023
Effectiveness of remimazolam besylate combined with alfentanil for fiberoptic bronchoscopy with preserved spontaneous breathing: a prospective, randomized, controlled clinical trial.
    European review for medical and pharmacological sciences, 2023, Volume: 27, Issue:13

    Topics: Alfentanil; Benzodiazepines; Bronchoscopy; Humans; Hypnotics and Sedatives; Hypotension; Propofol; P

2023
Comparison of remimazolam and propofol induction on hemodynamic response in hypertensive patients.
    Medicine, 2023, Jul-28, Volume: 102, Issue:30

    Topics: Anesthesia, General; Hemodynamics; Humans; Hypertension; Hypotension; Propofol

2023
The safety and efficacy of remimazolam tosylate combined with propofol in upper gastrointestinal endoscopy: A multicenter, randomized clinical trial.
    PloS one, 2023, Volume: 18, Issue:8

    Topics: Benzodiazepines; Endoscopy, Gastrointestinal; Humans; Hypnotics and Sedatives; Hypotension; Propofol

2023
The preventive effect of 5-hydroxytryptamine-3 receptor antagonist on blood pressure reduction and postoperative nausea and vomiting during general anesthesia induction: A double-blinded, randomized controlled trial.
    Journal of clinical anesthesia, 2023, Volume: 90

    Topics: Anesthesia, General; Blood Pressure; Ephedrine; Humans; Hypotension; Pain, Postoperative; Phenylephr

2023
Comparison of different ratios of propofol-ketamine admixture in rapid-sequence induction of anesthesia for emergency laparotomy: a randomized controlled trial.
    BMC anesthesiology, 2023, 10-03, Volume: 23, Issue:1

    Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Humans; Hypotension; Ketamine; Laparotomy; Nor

2023
Norepinephrine prevents hypotension in older patients under spinal anesthesia with intravenous propofol sedation: a randomized controlled trial.
    Scientific reports, 2023, Nov-29, Volume: 13, Issue:1

    Topics: Aged; Anesthesia, Spinal; Double-Blind Method; Humans; Hypotension; Norepinephrine; Postoperative Co

2023
Propofol for endotracheal intubation in neonates: a dose-finding trial.
    Archives of disease in childhood. Fetal and neonatal edition, 2020, Volume: 105, Issue:5

    Topics: Dose-Response Relationship, Drug; Female; Gestational Age; Humans; Hypnotics and Sedatives; Hypotens

2020
Efficacy of an Oxycodone-Propofol Combination versus a Fentanyl-Propofol Combination in Conscious Sedation during Therapeutic Endoscopic Retrograde Cholangiopancreatography in Elderly Patients.
    Gerontology, 2021, Volume: 67, Issue:1

    Topics: Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Bradycardia; Cholangiopancreatography, E

2021
Effect of remimazolam induction on hemodynamics in patients undergoing valve replacement surgery: A randomized, double-blind, controlled trial.
    Pharmacology research & perspectives, 2021, Volume: 9, Issue:5

    Topics: Adult; Aged; Anesthetics, Intravenous; Aortic Valve; Arterial Pressure; Benzodiazepines; Bradycardia

2021
Thoracic Epidural Analgesia With Levobupivacaine Reduces Remifentanil and Propofol Consumption Evaluated by Closed-Loop Titration Guided by the Bispectral Index: A Double-Blind Placebo-Controlled Study.
    Anesthesia and analgesia, 2017, Volume: 125, Issue:2

    Topics: Aged; Analgesia, Epidural; Anesthesia, Closed-Circuit; Anesthesia, Epidural; Anesthetics, Intravenou

2017
Efficacy and safety of etomidate-based sedation compared with propofol-based sedation during ERCP in low-risk patients: a double-blind, randomized, noninferiority trial.
    Gastrointestinal endoscopy, 2018, Volume: 87, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Cholangiopancreatography, Endoscopic Retro

2018
Comparison of dexmedetomidine and fentanyl to prevent haemodynamic response to skull pin application in neurosurgery: double blind randomized controlled trial.
    Anaesthesiology intensive therapy, 2017, Volume: 49, Issue:4

    Topics: Adult; Anesthetics, Intravenous; Blood Pressure; Bone Nails; Craniotomy; Dexmedetomidine; Double-Bli

2017
Bispectral index to guide induction of anesthesia: a randomized controlled study.
    BMC anesthesiology, 2018, 06-15, Volume: 18, Issue:1

    Topics: Adult; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pressure; Consc

2018
Use of propofol for prevention of post-delivery nausea during cesarean section: a double-blind, randomized, placebo-controlled trial.
    Journal of anesthesia, 2018, Volume: 32, Issue:5

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Antiemetics; Cesarean Sect

2018
A randomized controlled trial comparing methohexital and propofol for induction in patients receiving angiotensin axis blockade.
    Medicine, 2019, Volume: 98, Issue:5

    Topics: Aged; Anesthesia; Anesthetics, Intravenous; Angiotensin II; Angiotensin Receptor Antagonists; Angiot

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Early Sedation with Dexmedetomidine in Critically Ill Patients.
    The New England journal of medicine, 2019, 06-27, Volume: 380, Issue:26

    Topics: Adult; Aged; Bradycardia; Conscious Sedation; Critical Illness; Dexmedetomidine; Drug Therapy, Combi

2019
Comparison between hemodynamic effects of propofol and thiopental during general anesthesia induction with remifentanil infusion: a double-blind, age-stratified, randomized study.
    Journal of anesthesia, 2019, Volume: 33, Issue:4

    Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Arterial Pressure; Double-Blind Method;

2019
Ketamine/propofol admixture vs etomidate for intubation in the critically ill: KEEP PACE Randomized clinical trial.
    The journal of trauma and acute care surgery, 2019, Volume: 87, Issue:4

    Topics: Adult; Anesthetics, Intravenous; Critical Illness; Dose-Response Relationship, Drug; Drug Monitoring

2019
The potential regimen of target-controlled infusion of propofol in flexible bronchoscopy sedation: a randomized controlled trial.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Aged; Anesthetics, Intravenous; Bronchoscopes; Conscious Sedation; Female; Humans; Hypotension; Hypo

2013
The potential regimen of target-controlled infusion of propofol in flexible bronchoscopy sedation: a randomized controlled trial.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Aged; Anesthetics, Intravenous; Bronchoscopes; Conscious Sedation; Female; Humans; Hypotension; Hypo

2013
The potential regimen of target-controlled infusion of propofol in flexible bronchoscopy sedation: a randomized controlled trial.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Aged; Anesthetics, Intravenous; Bronchoscopes; Conscious Sedation; Female; Humans; Hypotension; Hypo

2013
The potential regimen of target-controlled infusion of propofol in flexible bronchoscopy sedation: a randomized controlled trial.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Aged; Anesthetics, Intravenous; Bronchoscopes; Conscious Sedation; Female; Humans; Hypotension; Hypo

2013
The potential regimen of target-controlled infusion of propofol in flexible bronchoscopy sedation: a randomized controlled trial.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Aged; Anesthetics, Intravenous; Bronchoscopes; Conscious Sedation; Female; Humans; Hypotension; Hypo

2013
The potential regimen of target-controlled infusion of propofol in flexible bronchoscopy sedation: a randomized controlled trial.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Aged; Anesthetics, Intravenous; Bronchoscopes; Conscious Sedation; Female; Humans; Hypotension; Hypo

2013
The potential regimen of target-controlled infusion of propofol in flexible bronchoscopy sedation: a randomized controlled trial.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Aged; Anesthetics, Intravenous; Bronchoscopes; Conscious Sedation; Female; Humans; Hypotension; Hypo

2013
The potential regimen of target-controlled infusion of propofol in flexible bronchoscopy sedation: a randomized controlled trial.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Aged; Anesthetics, Intravenous; Bronchoscopes; Conscious Sedation; Female; Humans; Hypotension; Hypo

2013
The potential regimen of target-controlled infusion of propofol in flexible bronchoscopy sedation: a randomized controlled trial.
    PloS one, 2013, Volume: 8, Issue:4

    Topics: Aged; Anesthetics, Intravenous; Bronchoscopes; Conscious Sedation; Female; Humans; Hypotension; Hypo

2013
The effect of nitrous oxide inhalation on the hypotensive response to propofol: a randomized controlled trial.
    Oral surgery, oral medicine, oral pathology and oral radiology, 2014, Volume: 118, Issue:2

    Topics: Administration, Inhalation; Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Pressure

2014
Preoperative oral rehydration solution intake volume does not affect relative change of mean arterial blood pressure and crystalloid redistribution during general anesthesia in low-risk patients: an observational cohort study.
    Journal of anesthesia, 2014, Volume: 28, Issue:1

    Topics: Adult; Anesthesia, General; Blood Pressure; Cohort Studies; Female; Humans; Hypotension; Isotonic So

2014
Clinical evaluation of propofol as sedative for endotracheal intubation in neonates.
    Acta paediatrica (Oslo, Norway : 1992), 2013, Volume: 102, Issue:11

    Topics: Anesthetics, Intravenous; Humans; Hypotension; Infant, Newborn; Intensive Care, Neonatal; Intubation

2013
Stepwise sedation for elderly patients with mild/moderate COPD during upper gastrointestinal endoscopy.
    World journal of gastroenterology, 2013, Aug-07, Volume: 19, Issue:29

    Topics: Age Factors; Aged; Aged, 80 and over; Biomarkers; Blood Pressure; Chi-Square Distribution; China; Dr

2013
Minimal and deep sedation during ablation of ventricular tachycardia.
    International journal of cardiology, 2014, Mar-01, Volume: 172, Issue:1

    Topics: Acidosis; Adult; Aged; Bradycardia; Catheter Ablation; Conscious Sedation; Deep Sedation; Feasibilit

2014
Intrathecal fentanyl decreases the optimal effect site concentration of propofol during spinal anaesthesia.
    Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:5

    Topics: Adjuvants, Anesthesia; Aged; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics, Local; Bupiv

2014
Midazolam and propofol used alone or sequentially for long-term sedation in critically ill, mechanically ventilated patients: a prospective, randomized study.
    Critical care (London, England), 2014, Jun-16, Volume: 18, Issue:3

    Topics: Akathisia, Drug-Induced; Anesthesia Recovery Period; Anesthetics, Intravenous; Critical Illness; Dru

2014
Blood pressure response to combined general anaesthesia/interscalene brachial plexus block for outpatient shoulder arthroscopy.
    BMC anesthesiology, 2014, Volume: 14

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Anesthesia, General; Ane

2014
A randomized controlled trial of the effect of preoperative dexmedetomidine on the half maximal effective concentration of propofol for successful i-gel insertion without muscle relaxants.
    Journal of anesthesia, 2015, Volume: 29, Issue:3

    Topics: Adult; Anesthesia, General; Bradycardia; Cough; Dexmedetomidine; Female; Heart Rate; Humans; Hypoten

2015
Hemodynamic responses during induction: comparison of Marsh and Schnider pharmacokinetic models.
    International journal of clinical pharmacology and therapeutics, 2015, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Anesthetics, Intravenous; Body Mass Index; China; Dose-Response Relationship, Dru

2015
A prospective, randomized controlled trial of conscious sedation using propofol combined with inhaled nitrous oxide for dental treatment.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2015, Volume: 73, Issue:3

    Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Inh

2015
Comparison of the hemodynamic response to induction and intubation during a target-controlled infusion of propofol with 2 different pharmacokinetic models. A prospective ramdomized trial.
    Revista espanola de anestesiologia y reanimacion, 2015, Volume: 62, Issue:9

    Topics: Adult; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Consciousness Monitor

2015
A presedation fluid bolus does not decrease the incidence of propofol-induced hypotension in pediatric patients.
    Hospital pediatrics, 2015, Volume: 5, Issue:2

    Topics: Child, Preschool; Conscious Sedation; Drug Monitoring; Evoked Potentials, Auditory, Brain Stem; Fema

2015
Propofol-ketamine combination: a choice with less complications and better hemodynamic stability compared to propofol? On a prospective study in a group of colonoscopy patients.
    Irish journal of medical science, 2016, Volume: 185, Issue:3

    Topics: Anesthetics, Combined; Colonoscopy; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; H

2016
A randomized, controlled trial to compare the efficacy and safety profile of a dexmedetomidine-ketamine combination with a propofol-fentanyl combination for ERCP.
    Gastrointestinal endoscopy, 2016, Volume: 83, Issue:5

    Topics: Adolescent; Adult; Aged; Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia Recover

2016
[Effects of dexmedetomidine on propofol dosage in target-controlled infusion and hemodynamics during laparoscopic surgery under general anesthesia].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2015, Volume: 35, Issue:10

    Topics: Anesthesia, General; Blood Pressure; Bradycardia; Dexmedetomidine; Heart Rate; Hemodynamics; Humans;

2015
Prewarming neurosurgical patients to minimize hypotension on induction of anesthesia: a randomized trial.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2016, Volume: 63, Issue:5

    Topics: Adult; Aged; Anesthetics, Intravenous; Blood Pressure; Body Temperature; Female; Heart Rate; Humans;

2016
Etomidate plus propofol versus propofol alone for sedation during gastroscopy: a randomized prospective clinical trial.
    Surgical endoscopy, 2016, Volume: 30, Issue:11

    Topics: Adult; Anesthetics, Intravenous; Attitude of Health Personnel; Bradycardia; Drug Therapy, Combinatio

2016
Determination of the appropriate propofol infusion rate for outpatient upper gastrointestinal endoscopy-a randomized prospective study.
    BMC gastroenterology, 2016, Apr-26, Volume: 16

    Topics: Adult; Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthetics, Intravenous; Conscio

2016
Bispectral Index Monitoring Reduces the Dosage of Propofol and Adverse Events in Sedation for Endobronchial Ultrasound.
    Respiration; international review of thoracic diseases, 2016, Volume: 92, Issue:3

    Topics: Aged; Anesthetics, Intravenous; Bronchoscopy; Consciousness Monitors; Deep Sedation; Endosonography;

2016
Comparing the efficacy and safety between propofol and dexmedetomidine for sedation in claustrophobic adults undergoing magnetic resonance imaging (PADAM trial).
    Journal of clinical anesthesia, 2016, Volume: 34

    Topics: Adult; Aged; Anxiety; Bradycardia; Conscious Sedation; Dexmedetomidine; Double-Blind Method; Female;

2016
The effect of prophylactic phenylephrine on systemic hypotension during induction of anaesthesia with propofol in patients over 55 years old.
    The Medical journal of Malaysia, 2016, Volume: 71, Issue:4

    Topics: Aged; Anesthesia; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension;

2016
[Efficacy of spinal anesthesia with small-dose lidocaine in ambulatory prostate biopsy procedures for elderly patients : comparison with propofol anesthesia].
    Masui. The Japanese journal of anesthesiology, 2008, Volume: 57, Issue:5

    Topics: Aged; Ambulatory Surgical Procedures; Anesthesia, General; Anesthesia, Spinal; Biopsy; Humans; Hypot

2008
Controlled hypotension in adults undergoing choroidal melanoma resection: comparison between the efficacy of nitroprusside and magnesium sulphate.
    European journal of anaesthesiology, 2008, Volume: 25, Issue:11

    Topics: Adult; Anesthetics, Intravenous; Blood Pressure; Choroid Neoplasms; Female; Heart Rate; Hemodynamics

2008
Prevention of hypotension during propofol induction: a comparison of preloading with 3.5% polymers of degraded gelatin (Haemaccel) and intravenous ephedrine.
    Nepal Medical College journal : NMCJ, 2008, Volume: 10, Issue:1

    Topics: Adult; Anesthesia; Anesthetics, Intravenous; Ephedrine; Female; Humans; Hypotension; Infusions, Intr

2008
[Peribulbar anesthesia: efficacy of a single injection with a limited local anesthetic volume].
    Journal francais d'ophtalmologie, 2008, Volume: 31, Issue:8

    Topics: Aged; Amides; Anesthetics, Local; Cataract Extraction; Dose-Response Relationship, Drug; Drug Combin

2008
Hypotensive anesthesia with esmolol. Assessment of hemodynamics, consumption of anesthetic drugs, and recovery.
    Saudi medical journal, 2009, Volume: 30, Issue:6

    Topics: Adolescent; Adult; Anesthetics; Hemodynamics; Humans; Hypotension; Middle Aged; Piperidines; Propano

2009
Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension.
    Neurocritical care, 2010, Volume: 12, Issue:1

    Topics: Adult; Aged; Anesthesia, General; Ephedrine; Female; Fentanyl; Frontal Lobe; Hemodynamics; Humans; H

2010
Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension.
    Neurocritical care, 2010, Volume: 12, Issue:1

    Topics: Adult; Aged; Anesthesia, General; Ephedrine; Female; Fentanyl; Frontal Lobe; Hemodynamics; Humans; H

2010
Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension.
    Neurocritical care, 2010, Volume: 12, Issue:1

    Topics: Adult; Aged; Anesthesia, General; Ephedrine; Female; Fentanyl; Frontal Lobe; Hemodynamics; Humans; H

2010
Phenylephrine but not ephedrine reduces frontal lobe oxygenation following anesthesia-induced hypotension.
    Neurocritical care, 2010, Volume: 12, Issue:1

    Topics: Adult; Aged; Anesthesia, General; Ephedrine; Female; Fentanyl; Frontal Lobe; Hemodynamics; Humans; H

2010
Can intravenous atropine prevent bradycardia and hypotension during induction of total intravenous anesthesia with propofol and remifentanil?
    Journal of anesthesia, 2010, Volume: 24, Issue:2

    Topics: Adult; Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Atropine; Bradycardia; Female; Human

2010
Dose-dependent hemodynamic effects of propofol induction following brotizolam premedication in hypertensive patients taking angiotensin-converting enzyme inhibitors.
    Journal of clinical anesthesia, 2010, Volume: 22, Issue:3

    Topics: Adult; Aged; Anesthetics, Intravenous; Angiotensin-Converting Enzyme Inhibitors; Azepines; Blood Pre

2010
Effect of auditory evoked potential-guided anaesthesia on consumption of anaesthetics and early postoperative cognitive dysfunction: a randomised controlled trial.
    European journal of anaesthesiology, 2011, Volume: 28, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Anesthesia, General; Anesthetics, General; C

2011
Sedation during upper GI endoscopy in cirrhotic outpatients: a randomized, controlled trial comparing propofol and fentanyl with midazolam and fentanyl.
    Gastrointestinal endoscopy, 2011, Volume: 73, Issue:1

    Topics: Analgesics, Opioid; Anesthesia Recovery Period; Bradycardia; Conscious Sedation; Deep Sedation; Endo

2011
Hydration status after overnight fasting as measured by urine osmolality does not alter the magnitude of hypotension during general anesthesia in low risk patients.
    Anesthesia and analgesia, 2011, Volume: 112, Issue:6

    Topics: Adult; Anesthesia, General; Blood Pressure; Crystallization; Electric Impedance; Female; Fentanyl; H

2011
Dose requirement and complications of diluted and undiluted propofol for deep sedation in endoscopic retrograde cholangiopancreatography.
    Hepatobiliary & pancreatic diseases international : HBPD INT, 2011, Volume: 10, Issue:3

    Topics: Adult; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Cholangiopancreatography, Endosco

2011
Feasibility and safety of propofol sedation in flexible bronchoscopy.
    Swiss medical weekly, 2011, Volume: 141

    Topics: Adult; Aged; Bronchoscopy; Conscious Sedation; Feasibility Studies; Humans; Hypnotics and Sedatives;

2011
Moderate sedation for elective upper endoscopy with balanced propofol versus fentanyl and midazolam alone: a randomized clinical trial.
    Endoscopy, 2012, Volume: 44, Issue:1

    Topics: Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Apnea; Deep Sedation; Endoscopy, Digesti

2012
Bispectral index monitoring of midazolam and propofol sedation during endoscopic retrograde cholangiopancreatography: a randomized clinical trial (the EndoBIS study).
    Endoscopy, 2012, Volume: 44, Issue:3

    Topics: Aged; Aged, 80 and over; Anesthesia Recovery Period; Bradycardia; Cholangiopancreatography, Endoscop

2012
Intermittent manually controlled versus continuous infusion of propofol for deep sedation during interventional endoscopy: a prospective randomized trial.
    Scandinavian journal of gastroenterology, 2012, Volume: 47, Issue:8-9

    Topics: Anesthesia Recovery Period; Cholangiopancreatography, Endoscopic Retrograde; Deep Sedation; Endosono

2012
Propofol sedation with bispectral index monitoring is useful for endoscopic submucosal dissection: a randomized prospective phase II clinical trial.
    Endoscopy, 2012, Volume: 44, Issue:6

    Topics: Adenoma; Aged; Aged, 80 and over; Anesthetics, Intravenous; Bradycardia; Chi-Square Distribution; Co

2012
A comparison of 3 anesthetic protocols for 24 hours of mechanical ventilation in cats.
    Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001), 2012, Volume: 22, Issue:2

    Topics: Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Cats; Cross-

2012
Comparison of effects of ephedrine, lidocaine and ketamine with placebo on injection pain, hypotension and bradycardia due to propofol injection: a randomized placebo controlled clinical trial.
    Acta medica Iranica, 2012, Volume: 50, Issue:9

    Topics: Adult; Anesthetics, Intravenous; Bradycardia; Double-Blind Method; Ephedrine; Female; Humans; Hypote

2012
Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized, clinical trial.
    British journal of anaesthesia, 2013, Volume: 110, Issue:3

    Topics: Abdomen; Abdominal Neoplasms; Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Arterial P

2013
Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized, clinical trial.
    British journal of anaesthesia, 2013, Volume: 110, Issue:3

    Topics: Abdomen; Abdominal Neoplasms; Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Arterial P

2013
Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized, clinical trial.
    British journal of anaesthesia, 2013, Volume: 110, Issue:3

    Topics: Abdomen; Abdominal Neoplasms; Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Arterial P

2013
Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized, clinical trial.
    British journal of anaesthesia, 2013, Volume: 110, Issue:3

    Topics: Abdomen; Abdominal Neoplasms; Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Arterial P

2013
Low effect-site concentration of propofol target-controlled infusion reduces the risk of hypotension during endoscopy in a Taiwanese population.
    Journal of digestive diseases, 2013, Volume: 14, Issue:3

    Topics: Adult; Aged; Anesthetics, Intravenous; Conscious Sedation; Dose-Response Relationship, Drug; Drug Ad

2013
Spinal block or total intravenous anaesthesia with propofol and remifentanil for gynaecological outpatient procedures.
    European journal of anaesthesiology, 2002, Volume: 19, Issue:8

    Topics: Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, Spinal; Anesthetics, Combined; Anesthetics,

2002
[Effect of propofol and propofol combined with ketamine on cardiovascular system].
    Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 2000, Apr-28, Volume: 25, Issue:2

    Topics: Adolescent; Adult; Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Blood

2000
Patient-controlled sedation versus intravenous sedation for colonoscopy in elderly patients: a prospective randomized controlled trial.
    Gastrointestinal endoscopy, 2002, Volume: 56, Issue:5

    Topics: Aged; Alfentanil; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Colonoscopy; Conscious Se

2002
Patient-controlled sedation versus intravenous sedation for colonoscopy in elderly patients: a prospective randomized controlled trial.
    Gastrointestinal endoscopy, 2002, Volume: 56, Issue:5

    Topics: Aged; Alfentanil; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Colonoscopy; Conscious Se

2002
Patient-controlled sedation versus intravenous sedation for colonoscopy in elderly patients: a prospective randomized controlled trial.
    Gastrointestinal endoscopy, 2002, Volume: 56, Issue:5

    Topics: Aged; Alfentanil; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Colonoscopy; Conscious Se

2002
Patient-controlled sedation versus intravenous sedation for colonoscopy in elderly patients: a prospective randomized controlled trial.
    Gastrointestinal endoscopy, 2002, Volume: 56, Issue:5

    Topics: Aged; Alfentanil; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Colonoscopy; Conscious Se

2002
Propofol for procedural sedation in children in the emergency department.
    Annals of emergency medicine, 2003, Volume: 42, Issue:6

    Topics: Adjuvants, Anesthesia; Adolescent; Analgesics, Opioid; Anesthetics, Combined; Bradycardia; Child; Ch

2003
Propofol sedation by emergency physicians for elective pediatric outpatient procedures.
    Annals of emergency medicine, 2003, Volume: 42, Issue:6

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Ambulatory Care; Bradycardia; Child; Child, Preschool; Cli

2003
Cost-effectiveness and high patient satisfaction in the elderly: sevoflurane versus propofol anaesthesia.
    European journal of anaesthesiology, 2004, Volume: 21, Issue:2

    Topics: Aged; Analysis of Variance; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intrav

2004
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:6

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti

2003
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:6

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti

2003
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:6

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti

2003
Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:6

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Ambulatory Care; Anesthesia Recovery Period; Attenti

2003
Effect of preoperative discontinuation of antipsychotics in schizophrenic patients on outcome during and after anaesthesia.
    European journal of anaesthesiology, 2004, Volume: 21, Issue:5

    Topics: Adult; Analysis of Variance; Anesthesia; Anesthesia Recovery Period; Anesthetics, Intravenous; Antip

2004
Hydroxyethylstarch 6% preload does not prevent the hypotension following induction with propofol and fentanyl.
    Middle East journal of anaesthesiology, 2004, Volume: 17, Issue:5

    Topics: Adult; Anesthetics, Intravenous; Blood Pressure; Electrocardiography; Female; Fentanyl; Heart Rate;

2004
A prospective, randomized, double-blind comparison of unilateral spinal anesthesia with hyperbaric bupivacaine, ropivacaine, or levobupivacaine for inguinal herniorrhaphy.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:5

    Topics: Aged; Air Pressure; Amides; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Digestive System Su

2004
Induced hypotension for tympanoplasty: a comparison of desflurane, isoflurane and sevoflurane.
    European journal of anaesthesiology, 2004, Volume: 21, Issue:11

    Topics: Adolescent; Adult; Analgesics, Opioid; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics,

2004
Propofol for deep procedural sedation in the ED.
    The American journal of emergency medicine, 2005, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Analgesics, Opioid; Apnea; Conscious Sedation; Dose-Response Relationship, Drug;

2005
Comparison of ephedrine and ketamine in prevention of injection pain and hypotension due to propofol induction.
    European journal of anaesthesiology, 2005, Volume: 22, Issue:1

    Topics: Aged; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; Double-Blind Met

2005
Effect of hypercapnia on arterial hypotension after induction of anaesthesia.
    Acta anaesthesiologica Scandinavica, 2005, Volume: 49, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intraveno

2005
Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study.
    The American journal of gastroenterology, 2005, Volume: 100, Issue:9

    Topics: Aged; Cholangiopancreatography, Endoscopic Retrograde; Comorbidity; Conscious Sedation; Feasibility

2005
Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study.
    The American journal of gastroenterology, 2005, Volume: 100, Issue:9

    Topics: Aged; Cholangiopancreatography, Endoscopic Retrograde; Comorbidity; Conscious Sedation; Feasibility

2005
Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study.
    The American journal of gastroenterology, 2005, Volume: 100, Issue:9

    Topics: Aged; Cholangiopancreatography, Endoscopic Retrograde; Comorbidity; Conscious Sedation; Feasibility

2005
Sedation with propofol for routine ERCP in high-risk octogenarians: a randomized, controlled study.
    The American journal of gastroenterology, 2005, Volume: 100, Issue:9

    Topics: Aged; Cholangiopancreatography, Endoscopic Retrograde; Comorbidity; Conscious Sedation; Feasibility

2005
A comparison of spinal anesthesia with small-dose lidocaine and general anesthesia with fentanyl and propofol for ambulatory prostate biopsy procedures in elderly patients.
    Journal of clinical anesthesia, 2007, Volume: 19, Issue:1

    Topics: Aged; Aged, 80 and over; Ambulatory Surgical Procedures; Analysis of Variance; Anesthesia Recovery P

2007
Preoperative ultra short-term entropy predicts arterial blood pressure fluctuation during the induction of anesthesia.
    Anesthesia and analgesia, 2007, Volume: 104, Issue:4

    Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Blood Pressure; Electrocardiography; Entropy;

2007
Propofol causes more hypotension than etomidate in patients with severe aortic stenosis: a double-blind, randomized study comparing propofol and etomidate.
    Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:3

    Topics: Aged; Analysis of Variance; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous;

2007
Autonomic cardiac control with xenon anaesthesia in patients at cardiovascular risk.
    British journal of anaesthesia, 2007, Volume: 98, Issue:6

    Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Autonomic Nervous System; Blood Pressure; E

2007
The effect of ephedrine on intubating conditions and haemodynamics during rapid tracheal intubation using propofol and rocuronium.
    British journal of anaesthesia, 2007, Volume: 99, Issue:2

    Topics: Adolescent; Adult; Androstanols; Anesthesia, General; Anesthetics, Intravenous; Blood Pressure; Dose

2007
Attenuation of hypotension using phenylephrine during induction of anaesthesia with propofol.
    JPMA. The Journal of the Pakistan Medical Association, 2007, Volume: 57, Issue:11

    Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Cardiotonic Agents; Female; Humans; Hypotension;

2007
Prevention of propofol-induced injection pain by sufentanil: a placebo-controlled comparison with remifentanil.
    Clinical drug investigation, 2008, Volume: 28, Issue:1

    Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Dose-Response Relationship, Drug; Double-Blind

2008
Hypotensive anesthesia with propofol and remifentanil: protective effect of alpha-tocopherol on renal function.
    Journal of clinical anesthesia, 2008, Volume: 20, Issue:3

    Topics: Acetylglucosaminidase; Adult; alpha-Tocopherol; Anesthesia, Intravenous; Anesthetics, Intravenous; A

2008
A comparison of propofol and isoflurane anaesthesia: the need for ephedrine and glycopyrrolate.
    European journal of anaesthesiology, 1995, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Anesthesia, Inhalation; Anesthesia, Intraven

1995
Modulating effects of lignocaine on propofol.
    Anaesthesia and intensive care, 1995, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Aged; Akathisia, Drug-Induced; Anesthesia, Intravenous; Female; Forearm; Hand; Hu

1995
Hemodynamic effects of propofol: data from over 25,000 patients.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:4 Suppl

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Intravenous; Bradycardia; Female; Humans; Hy

1993
Hemodynamic effects of propofol: data from over 25,000 patients.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:4 Suppl

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Intravenous; Bradycardia; Female; Humans; Hy

1993
Hemodynamic effects of propofol: data from over 25,000 patients.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:4 Suppl

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Intravenous; Bradycardia; Female; Humans; Hy

1993
Hemodynamic effects of propofol: data from over 25,000 patients.
    Anesthesia and analgesia, 1993, Volume: 77, Issue:4 Suppl

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Intravenous; Bradycardia; Female; Humans; Hy

1993
A comparison of propofol with methohexital and isoflurane in two general anesthetic techniques.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1993, Volume: 51, Issue:10

    Topics: Adolescent; Adult; Alfentanil; Anesthesia Recovery Period; Anesthesia, Dental; Anesthesia, General;

1993
The haemodynamic effects of propofol in combination with ephedrine.
    Anaesthesia, 1996, Volume: 51, Issue:5

    Topics: Adult; Anesthetics, Intravenous; Blood Pressure; Dose-Response Relationship, Drug; Ephedrine; Female

1996
Prophylaxis against the systemic hypotension induced by propofol during rapid-sequence intubation.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1995, Volume: 42, Issue:10

    Topics: Adult; Anesthetics, Intravenous; Blood Pressure; Ephedrine; Female; Humans; Hypotension; Intubation,

1995
Hemodynamic effects, myocardial ischemia, and timing of tracheal extubation with propofol-based anesthesia for cardiac surgery.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:1

    Topics: Aged; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Coronary Artery Bypass; Enflura

1997
The arterial blood propofol concentration preventing movement in 50% of healthy women after skin incision.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Biopsy; Blood Pressure; Breast; Dermatolog

1997
Prophylactic ephedrine attenuates the hemodynamic response to propofol in elderly female patients.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:3

    Topics: Aged; Anesthetics, Intravenous; Blood Pressure; Ephedrine; Female; Fentanyl; Heart Rate; Humans; Hyp

1998
Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings.
    Epilepsia, 1998, Volume: 39, Issue:1

    Topics: Adult; Aged; Barbiturates; Clinical Protocols; Drug Administration Schedule; Drug Therapy, Combinati

1998
Administration of a crystalloid fluid preload does not prevent the decrease in arterial blood pressure after induction of anaesthesia with propofol and fentanyl.
    British journal of anaesthesia, 1998, Volume: 80, Issue:6

    Topics: Adult; Anesthetics, Intravenous; Crystalloid Solutions; Female; Fentanyl; Fluid Therapy; Heart Rate;

1998
Haemodynamic effects of induction of general anaesthesia with propofol during epidural anaesthesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:11

    Topics: Analysis of Variance; Anesthesia, Epidural; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood

1998
Effects of nicardipine-, nitroglycerin-, and prostaglandin E1-induced hypotension on human cerebrovascular carbon dioxide reactivity during propofol-fentanyl anesthesia.
    Journal of clinical anesthesia, 1999, Volume: 11, Issue:7

    Topics: Adult; Alprostadil; Analysis of Variance; Anesthetics, Intravenous; Antihypertensive Agents; Blood F

1999
Ephedrine, dopamine, or dobutamine to treat hypotension with propofol during epidural anesthesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2000, Volume: 47, Issue:3

    Topics: Adrenergic Agents; Analysis of Variance; Anesthesia, Epidural; Anesthetics, Intravenous; Anesthetics

2000
The effect of prophylactic metaraminol on systemic hypotension caused by induction of anaesthesia with propofol in patients over 55 years old.
    Anaesthesia, 2001, Volume: 56, Issue:9

    Topics: Adrenergic alpha-Agonists; Aged; Anesthesia, General; Anesthetics, Intravenous; Blood Pressure; Doub

2001
Influence of hypotensive and normotensive anesthesia on platelet aggregability and hemostatic markers in orthognathic surgery.
    Thrombosis research, 2001, Aug-01, Volume: 103, Issue:3

    Topics: Adult; Anesthesia; Anesthetics, Intravenous; Biomarkers; Blood Loss, Surgical; Female; Hemostasis; H

2001
Terlipressin-ephedrine versus ephedrine to treat hypotension at the induction of anesthesia in patients chronically treated with angiotensin converting-enzyme inhibitors: a prospective, randomized, double-blinded, crossover study.
    Anesthesia and analgesia, 2002, Volume: 94, Issue:4

    Topics: Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Angiotensin-Converting Enzyme Inhibitors; B

2002
Venodilation contributes to propofol-mediated hypotension in humans.
    Anesthesia and analgesia, 1992, Volume: 74, Issue:6

    Topics: Adult; Aged; Anesthesia; Blood Pressure; Carbon Dioxide; Cardiac Output; Electroencephalography; For

1992
The effect of pre-induction glycopyrronium on the haemodynamic response of elderly patients to anaesthesia with propofol.
    Anaesthesia, 1992, Volume: 47, Issue:7

    Topics: Aged; Aged, 80 and over; Anesthesia, Intravenous; Blood Pressure; Double-Blind Method; Female; Glyco

1992

Other Studies

141 other studies available for propofol and Hypotension

ArticleYear
Hemodynamic Effects of Ketamine Compared With Propofol or Dexmedetomidine as Continuous ICU Sedation.
    The Annals of pharmacotherapy, 2022, Volume: 56, Issue:7

    Topics: Adult; Bradycardia; Dexmedetomidine; Hemodynamics; Humans; Hypnotics and Sedatives; Hypotension; Int

2022
Gene-gene interactions in the protein kinase C/endothelial nitric oxide synthase axis impact the hypotensive effects of propofol.
    Basic & clinical pharmacology & toxicology, 2022, Volume: 130, Issue:2

    Topics: Adult; Aged; Anesthetics, Intravenous; Cross-Sectional Studies; Female; Genotype; Haplotypes; Humans

2022
Comparison of effectiveness, cost and safety between moderate sedation and deep sedation under esophagogastroduodenoscopy in Chinese population: a quasi-experimental study.
    Scandinavian journal of gastroenterology, 2022, Volume: 57, Issue:9

    Topics: Aged; Conscious Sedation; Cost-Benefit Analysis; Deep Sedation; Endoscopy, Digestive System; Humans;

2022
Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65.
    Journal of clinical anesthesia, 2022, Volume: 80

    Topics: Aged; Anesthetics, Intravenous; Humans; Hypotension; Propofol; Retrospective Studies; Surgical Wound

2022
Isoelectric Electroencephalography in Infants and Toddlers during Anesthesia for Surgery: An International Observational Study.
    Anesthesiology, 2022, 08-01, Volume: 137, Issue:2

    Topics: Adult; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Child, Preschool; Elect

2022
Isoelectric Electroencephalography in Infants and Toddlers during Anesthesia for Surgery: An International Observational Study.
    Anesthesiology, 2022, 08-01, Volume: 137, Issue:2

    Topics: Adult; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Child, Preschool; Elect

2022
Isoelectric Electroencephalography in Infants and Toddlers during Anesthesia for Surgery: An International Observational Study.
    Anesthesiology, 2022, 08-01, Volume: 137, Issue:2

    Topics: Adult; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Child, Preschool; Elect

2022
Isoelectric Electroencephalography in Infants and Toddlers during Anesthesia for Surgery: An International Observational Study.
    Anesthesiology, 2022, 08-01, Volume: 137, Issue:2

    Topics: Adult; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Child, Preschool; Elect

2022
Effects of intravenous acepromazine and butorphanol on propofol dosage for induction of anesthesia in healthy Beagle dogs.
    Veterinary anaesthesia and analgesia, 2022, Volume: 49, Issue:4

    Topics: Acepromazine; Anesthesia; Animals; Apnea; Butorphanol; Dog Diseases; Dogs; Female; Hypotension; Male

2022
Comment on: "Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65".
    Journal of clinical anesthesia, 2022, Volume: 81

    Topics: Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Humans; Hypotension; Propofol

2022
Comparison of Standard-Dose Versus High-Dose Dexmedetomidine in Extracorporeal Membrane Oxygenation.
    The Annals of pharmacotherapy, 2023, Volume: 57, Issue:2

    Topics: Adult; Analgesics; Bradycardia; Dexmedetomidine; Extracorporeal Membrane Oxygenation; Humans; Hypnot

2023
Response to comment on: "Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65".
    Journal of clinical anesthesia, 2022, Volume: 81

    Topics: Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Humans; Hypotension; Propofol

2022
Blockade of endothelial Mas receptor restores the vasomotor response to phenylephrine in human resistance arterioles pretreated with captopril and exposed to propofol.
    BMC anesthesiology, 2022, 07-29, Volume: 22, Issue:1

    Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Arterioles; Captopril; Humans; Hypotension

2022
Low-dose adjuvant dexmedetomidine did not decrease propofol sedation requirements in children undergoing gastrointestinal endoscopy.
    Pharmacotherapy, 2022, Volume: 42, Issue:10

    Topics: Anesthesia; Child; Cohort Studies; Dexmedetomidine; Endoscopy, Gastrointestinal; Humans; Hypnotics a

2022
Target-controlled infusion during MitraClip procedures in deep-sedation with spontaneous breathing.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:22

    Topics: Anesthesia, General; Drug-Related Side Effects and Adverse Reactions; Humans; Hypotension; Propofol;

2022
Target-controlled infusion during MitraClip procedures in deep-sedation with spontaneous breathing.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:22

    Topics: Anesthesia, General; Drug-Related Side Effects and Adverse Reactions; Humans; Hypotension; Propofol;

2022
Target-controlled infusion during MitraClip procedures in deep-sedation with spontaneous breathing.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:22

    Topics: Anesthesia, General; Drug-Related Side Effects and Adverse Reactions; Humans; Hypotension; Propofol;

2022
Target-controlled infusion during MitraClip procedures in deep-sedation with spontaneous breathing.
    European review for medical and pharmacological sciences, 2022, Volume: 26, Issue:22

    Topics: Anesthesia, General; Drug-Related Side Effects and Adverse Reactions; Humans; Hypotension; Propofol;

2022
A 67-Year-Old Woman With Fluctuating Hypertension and Hypotension After Elective Surgery.
    Chest, 2023, Volume: 163, Issue:1

    Topics: Aged; Dexmedetomidine; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Hypotension; Neuromu

2023
5-Aminolevulinic acid hydrochloride enhances bupivacaine-induced hypotension in spontaneously hypertensive rats.
    Journal of pharmacological sciences, 2023, Volume: 152, Issue:1

    Topics: Aminolevulinic Acid; Amlodipine; Animals; Antihypertensive Agents; Blood Pressure; Bupivacaine; Hype

2023
Effects of smoking on controlled hypotension with nitroglycerin during ear-nose-throat surgery.
    Nigerian journal of clinical practice, 2023, Volume: 26, Issue:6

    Topics: Anesthesia, General; Humans; Hypotension; Hypotension, Controlled; Nicotine; Nitroglycerin; Pharynx;

2023
The risks of sedation and pain control during burn resuscitation: Increased opioids lead to over-resuscitation and hypotension.
    Burns : journal of the International Society for Burn Injuries, 2023, Volume: 49, Issue:7

    Topics: Adult; Analgesics, Opioid; Benzodiazepines; Burns; Dexmedetomidine; Fluid Therapy; Humans; Hypnotics

2023
Use of Propofol Plus Dexmedetomidine in Patients Experiencing Severe Alcohol Withdrawal in the Intensive Care Unit.
    Journal of clinical pharmacology, 2020, Volume: 60, Issue:4

    Topics: Alcoholism; Bradycardia; Critical Care; Dexmedetomidine; Drug Therapy, Combination; Female; Humans;

2020
Comparison of drugs used for intubation of pediatric trauma patients.
    Journal of pediatric surgery, 2020, Volume: 55, Issue:5

    Topics: Adolescent; Brain Injuries, Traumatic; Child; Child, Preschool; Etomidate; Female; Hospitals, Pediat

2020
Propofol sedation with a target-controlled infusion pump in elderly patients undergoing ERCP.
    Gastrointestinal endoscopy, 2020, Volume: 92, Issue:2

    Topics: Aged; Cholangiopancreatography, Endoscopic Retrograde; Conscious Sedation; Humans; Hypnotics and Sed

2020
DEXmedetomidine compared to PROpofol in NEurocritical Care [DEXPRONE]: A multicenter retrospective evaluation of clinical utility and safety.
    Journal of critical care, 2020, Volume: 60

    Topics: Adult; Aged; Bradycardia; Critical Care; Critical Illness; Dexmedetomidine; Female; Humans; Hypnotic

2020
Deep sedation using propofol target-controlled infusion for gastrointestinal endoscopic procedures: a retrospective cohort study.
    BMC anesthesiology, 2020, 08-10, Volume: 20, Issue:1

    Topics: Aged; Anesthetics, Intravenous; Cohort Studies; Deep Sedation; Drug Delivery Systems; Endoscopy, Gas

2020
Pre-treatment with the angiotensin receptor 1 blocker losartan protects renal blood flow and oxygen delivery after propofol-induced hypotension in pigs.
    Scientific reports, 2020, 10-21, Volume: 10, Issue:1

    Topics: Anesthetics, Intravenous; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Female; Hypoten

2020
Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability.
    European journal of clinical pharmacology, 2021, Volume: 77, Issue:6

    Topics: Adult; Aged; Anesthetics, Intravenous; Arginase; Female; Genotype; Haplotypes; Humans; Hypotension;

2021
Mechanisms contributing to hypotension after anesthetic induction with sufentanil, propofol, and rocuronium: a prospective observational study.
    Journal of clinical monitoring and computing, 2022, Volume: 36, Issue:2

    Topics: Anesthetics; Anesthetics, Intravenous; Blood Pressure; Hemodynamics; Humans; Hypotension; Propofol;

2022
Causes of arterial hypotension during anesthetic induction with propofol investigated with perfusion index and ClearSightTM in young and elderly patients.
    Minerva anestesiologica, 2021, Volume: 87, Issue:6

    Topics: Aged; Anesthetics; Anesthetics, Intravenous; Blood Pressure; Humans; Hypotension; Perfusion Index; P

2021
Predicting hypotension during anesthesia: Variation in pulse oximetry plethysmography predicts propofol-induced hypotension in children.
    Paediatric anaesthesia, 2021, Volume: 31, Issue:8

    Topics: Anesthesia; Blood Pressure; Child; Humans; Hypotension; Hypotension, Controlled; Oximetry; Plethysmo

2021
Deceleration capacity of heart rate variability as a predictor of sedation related hypotension.
    Scientific reports, 2021, 05-25, Volume: 11, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Cohort Studies; Electrocardiography; Female; H

2021
Propofol-induced uric acid crystals: A case of cloudy urine.
    Paediatric anaesthesia, 2021, Volume: 31, Issue:10

    Topics: Adolescent; Anesthetics, Intravenous; Bradycardia; Child; Humans; Hypotension; Male; Propofol; Uric

2021
Bradyarrhythmia and hypotension during anesthetic induction-reconsideration of nifedipine: a case report.
    The Journal of international medical research, 2021, Volume: 49, Issue:8

    Topics: Anesthetics; Bradycardia; Humans; Hypotension; Nifedipine; Propofol

2021
The First US Clinical Experience With Computer-Assisted Propofol Sedation: A Retrospective Observational Comparative Study on Efficacy, Safety, Efficiency, and Endoscopist and Patient Satisfaction.
    Anesthesia and analgesia, 2017, Volume: 125, Issue:3

    Topics: Aged; Anesthesiologists; Conscious Sedation; Drug Therapy, Computer-Assisted; Endoscopy; Female; Hum

2017
An Analysis of Substandard Propofol Detected in Use in Zambian Anesthesia.
    Anesthesia and analgesia, 2017, Volume: 125, Issue:2

    Topics: Anesthesia; Anesthesiology; Anesthetics, Intravenous; Bronchial Spasm; Drug Contamination; Gas Chrom

2017
A Simulation Study of Propofol Effect-Site Concentration for Appropriate Sedation in Pediatric Patients Undergoing Brain MRI: Pharmacodynamic Analysis.
    Yonsei medical journal, 2017, Volume: 58, Issue:6

    Topics: Adolescent; Anesthesia; Anesthetics, Intravenous; Bradycardia; Brain; Child; Dose-Response Relations

2017
Angiotensin converting enzyme inhibitors enhance the hypotensive effects of propofol by increasing nitric oxide production.
    Free radical biology & medicine, 2018, 02-01, Volume: 115

    Topics: Adrenergic beta-Antagonists; Anesthesia; Angiotensin Receptor Antagonists; Angiotensin-Converting En

2018
A Comparison of Safety and Efficacy of Dexmedetomidine and Propofol in Children with Autism and Autism Spectrum Disorders Undergoing Magnetic Resonance Imaging.
    Journal of autism and developmental disorders, 2018, Volume: 48, Issue:9

    Topics: Anesthesia, Intravenous; Autism Spectrum Disorder; Child; Child, Preschool; Dexmedetomidine; Female;

2018
Procedural sedation by advanced care paramedics for emergency gastrointestinal endoscopy.
    CJEM, 2019, Volume: 21, Issue:2

    Topics: Allied Health Personnel; Analgesics; Arrhythmias, Cardiac; Datasets as Topic; Emergency Service, Hos

2019
Hypotension after induction of general anesthesia: occurrence, risk factors, and therapy. A prospective multicentre observational study.
    Journal of anesthesia, 2018, Volume: 32, Issue:5

    Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Arterial Pressure; Blood Pressure; Blood

2018
Hypotension after induction of general anesthesia: occurrence, risk factors, and therapy. A prospective multicentre observational study.
    Journal of anesthesia, 2018, Volume: 32, Issue:5

    Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Arterial Pressure; Blood Pressure; Blood

2018
Hypotension after induction of general anesthesia: occurrence, risk factors, and therapy. A prospective multicentre observational study.
    Journal of anesthesia, 2018, Volume: 32, Issue:5

    Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Arterial Pressure; Blood Pressure; Blood

2018
Hypotension after induction of general anesthesia: occurrence, risk factors, and therapy. A prospective multicentre observational study.
    Journal of anesthesia, 2018, Volume: 32, Issue:5

    Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Arterial Pressure; Blood Pressure; Blood

2018
Hypotension after induction of general anesthesia: occurrence, risk factors, and therapy. A prospective multicentre observational study.
    Journal of anesthesia, 2018, Volume: 32, Issue:5

    Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Arterial Pressure; Blood Pressure; Blood

2018
Hypotension after induction of general anesthesia: occurrence, risk factors, and therapy. A prospective multicentre observational study.
    Journal of anesthesia, 2018, Volume: 32, Issue:5

    Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Arterial Pressure; Blood Pressure; Blood

2018
Hypotension after induction of general anesthesia: occurrence, risk factors, and therapy. A prospective multicentre observational study.
    Journal of anesthesia, 2018, Volume: 32, Issue:5

    Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Arterial Pressure; Blood Pressure; Blood

2018
Hypotension after induction of general anesthesia: occurrence, risk factors, and therapy. A prospective multicentre observational study.
    Journal of anesthesia, 2018, Volume: 32, Issue:5

    Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Arterial Pressure; Blood Pressure; Blood

2018
Hypotension after induction of general anesthesia: occurrence, risk factors, and therapy. A prospective multicentre observational study.
    Journal of anesthesia, 2018, Volume: 32, Issue:5

    Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Arterial Pressure; Blood Pressure; Blood

2018
[Hemodynamic effects of cafedrine/theodrenaline on anesthesia-induced hypotension].
    Der Anaesthesist, 2018, Volume: 67, Issue:10

    Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Blood Pressure; Drug Combinations; Femal

2018
Effects From Continuous Infusions of Dexmedetomidine and Propofol on Hemodynamic Stability in Critically Ill Adult Patients With Septic Shock.
    Journal of intensive care medicine, 2020, Volume: 35, Issue:9

    Topics: Adult; Aged; Bradycardia; Critical Care; Critical Care Outcomes; Critical Illness; Dexmedetomidine;

2020
Hemodynamic Effects of Propofol for Induction of Rapid Sequence Intubation in Traumatically Injured Patients.
    The American surgeon, 2018, Sep-01, Volume: 84, Issue:9

    Topics: Adult; Emergency Service, Hospital; Female; Hemodynamics; Hospital Mortality; Humans; Hypnotics and

2018
The Effects of Intravenous Lipid Emulsion Therapy in the Prevention of Depressive Effects of Propofol on Cardiovascular and Respiratory Systems: An Experimental Animal Study.
    Medicina (Kaunas, Lithuania), 2018, Dec-25, Volume: 55, Issue:1

    Topics: Anesthetics, Intravenous; Animals; Blood Pressure; Bradycardia; Fat Emulsions, Intravenous; Heart Ra

2018
Propofol sedation without endotracheal intubation is safe for endoscopic submucosal dissection in the esophagus and stomach.
    United European gastroenterology journal, 2019, Volume: 7, Issue:3

    Topics: Aged; Analgesics, Opioid; Anesthetics, Intravenous; Cough; Endoscopic Mucosal Resection; Esophageal

2019
Deep sedation for transvenous lead extraction: a large single-centre experience.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2019, Aug-01, Volume: 21, Issue:8

    Topics: Cardiac Catheters; Cardiac Imaging Techniques; Deep Sedation; Defibrillators, Implantable; Device Re

2019
Computer-Assisted Propofol Sedation for Esophagogastroduodenoscopy Is Effective, Efficient, and Safe.
    Digestive diseases and sciences, 2019, Volume: 64, Issue:12

    Topics: Adult; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Anesthetists; Blood Gas Monitorin

2019
Behavior of a dual closed-loop controller of propofol and remifentanil guided by the bispectral index for postoperative sedation of adult cardiac surgery patients: a preliminary open study.
    Journal of clinical monitoring and computing, 2020, Volume: 34, Issue:4

    Topics: Adult; Aged; Airway Extubation; Anesthesia, Closed-Circuit; Cardiac Surgical Procedures; Critical Ca

2020
Case report: profound hypotension after anesthetic induction with propofol in patients treated with rifampin.
    Anesthesia and analgesia, 2013, Volume: 117, Issue:1

    Topics: Adult; Aged; Anesthesia, Intravenous; Antibiotics, Antitubercular; Case-Control Studies; Drug Intera

2013
Incidence of intraoperative hypotension during isoflurane-fentanyl and propofol-fentanyl anaesthesia in dogs.
    Veterinary journal (London, England : 1997), 2013, Volume: 198, Issue:1

    Topics: Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Dog Diseases; Dogs;

2013
Increase in prominence of electrocardiographic J waves after a single dose of propofol in a patient with early ventricular repolarisation.
    Anaesthesia, 2014, Volume: 69, Issue:2

    Topics: Aged, 80 and over; Anesthetics, Intravenous; Electrocardiography; Female; Humans; Hypotension; Intra

2014
Safety and efficacy of propofol administered by paediatricians during procedural sedation in children.
    Acta paediatrica (Oslo, Norway : 1992), 2014, Volume: 103, Issue:2

    Topics: Child; Child, Preschool; Contraindications; Deep Sedation; Female; Humans; Hypotension; Infant; Lary

2014
Can a validated sleep apnea scoring system predict cardiopulmonary events using propofol sedation for routine EGD or colonoscopy? A prospective cohort study.
    Gastrointestinal endoscopy, 2014, Volume: 79, Issue:3

    Topics: Adult; Age Factors; Aged; Body Mass Index; Colonoscopy; Female; Humans; Hypnotics and Sedatives; Hyp

2014
Predictors of severe hypotension in neurocritical care patients sedated with propofol.
    Neurocritical care, 2014, Volume: 20, Issue:2

    Topics: Aged; Antihypertensive Agents; Arterial Pressure; Cohort Studies; Critical Care; Drug Administration

2014
Same-day bidirectional endoscopy with nonanesthesiologist administration of propofol: safety and cost-effectiveness compared with separated exams.
    European journal of gastroenterology & hepatology, 2014, Volume: 26, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bradycardia; Colonoscopy; Conscious Sedation; Cost-Benef

2014
Management and complications of anaesthesia during balloon valvuloplasty for pulmonic stenosis in dogs: 39 cases (2000 to 2012).
    The Journal of small animal practice, 2014, Volume: 55, Issue:4

    Topics: Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Intravenous; Animals; Arrhythmias, Card

2014
A comparison of severe hemodynamic disturbances between dexmedetomidine and propofol for sedation in neurocritical care patients.
    Critical care medicine, 2014, Volume: 42, Issue:7

    Topics: Academic Medical Centers; Adolescent; Adult; Aged; Aged, 80 and over; Bradycardia; Critical Care; De

2014
Anesthetic management and outcomes for patients with pulmonary hypertension and intracardiac shunts and Eisenmenger syndrome: a review of institutional experience.
    Journal of clinical anesthesia, 2014, Volume: 26, Issue:4

    Topics: Adolescent; Adult; Aged; Anesthesia; Anesthetics; Eisenmenger Complex; Etomidate; Hospitals, Univers

2014
[Retrospective evaluation of predictors and frequency of hypotension in hypertensive patients after induction of general anesthesia].
    Masui. The Japanese journal of anesthesiology, 2014, Volume: 63, Issue:6

    Topics: Age Factors; Aged; Anesthesia, General; Blood Pressure; Forecasting; Humans; Hypertension; Hypotensi

2014
[Incorrect programming of a target controlled infusion pump. Case SENSAR of the trimester].
    Revista espanola de anestesiologia y reanimacion, 2014, Volume: 61, Issue:8

    Topics: Anesthetics, General; Aortic Valve; Drug Overdose; Equipment Failure; Equipment Failure Analysis; He

2014
Cardiovascular Collapse After Induction.
    Journal of neurosurgical anesthesiology, 2015, Volume: 27, Issue:3

    Topics: Adrenergic alpha-Agonists; Aged, 80 and over; Anaphylaxis; Anesthetics, Intravenous; Anti-Allergic A

2015
[Ventricular fibrillation and cardiorespiratory arrest during dexmedetomidine administration].
    Revista espanola de anestesiologia y reanimacion, 2015, Volume: 62, Issue:10

    Topics: Adrenergic alpha-2 Receptor Agonists; Advanced Cardiac Life Support; Aged; Airway Extubation; Aortic

2015
Methodology of motor evoked potentials in a rabbit model.
    Translational stroke research, 2015, Volume: 6, Issue:5

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Apnea; Disease Models, Animal; Evoked Po

2015
Propofol sedation with a target-controlled infusion pump and bispectral index monitoring system in elderly patients during a complex upper endoscopy procedure.
    Gastrointestinal endoscopy, 2016, Volume: 83, Issue:4

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Blood Pressure; Deep Sedation; Dissection; Drug Monitor

2016
Extracorporeal membrane oxygenation and sustained low-efficiency diafiltration successfully resuscitated propofol infusion syndrome during refractory status epilepticus.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2015, Volume: 114, Issue:11

    Topics: Acute Kidney Injury; Administration, Intravenous; Adult; Extracorporeal Membrane Oxygenation; Humans

2015
Age correlates with hypotension during propofol-based anesthesia for endoscopic retrograde cholangiopancreatography.
    Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2015, Volume: 53, Issue:4

    Topics: Adult; Aged; Anesthesia; Cholangiopancreatography, Endoscopic Retrograde; Conscious Sedation; Humans

2015
[Abnormal Low Blood Pressure after Induction of General Anesthesia in a Patient on Medication for Depression].
    Masui. The Japanese journal of anesthesiology, 2015, Volume: 64, Issue:11

    Topics: Anesthesia, Epidural; Anesthesia, General; Anesthesia, Local; Anesthesia, Spinal; Anesthetics, Local

2015
Sedation during Minimal Invasive Surfactant Therapy in Preterm Infants.
    Neonatology, 2016, Volume: 109, Issue:4

    Topics: Birth Weight; Bradycardia; Female; Gestational Age; Humans; Hypnotics and Sedatives; Hypotension; In

2016
Sedation during Minimal Invasive Surfactant Therapy in Preterm Infants.
    Neonatology, 2016, Volume: 109, Issue:4

    Topics: Birth Weight; Bradycardia; Female; Gestational Age; Humans; Hypnotics and Sedatives; Hypotension; In

2016
Sedation during Minimal Invasive Surfactant Therapy in Preterm Infants.
    Neonatology, 2016, Volume: 109, Issue:4

    Topics: Birth Weight; Bradycardia; Female; Gestational Age; Humans; Hypnotics and Sedatives; Hypotension; In

2016
Sedation during Minimal Invasive Surfactant Therapy in Preterm Infants.
    Neonatology, 2016, Volume: 109, Issue:4

    Topics: Birth Weight; Bradycardia; Female; Gestational Age; Humans; Hypnotics and Sedatives; Hypotension; In

2016
Sedation during Minimal Invasive Surfactant Therapy in Preterm Infants.
    Neonatology, 2016, Volume: 109, Issue:4

    Topics: Birth Weight; Bradycardia; Female; Gestational Age; Humans; Hypnotics and Sedatives; Hypotension; In

2016
Sedation during Minimal Invasive Surfactant Therapy in Preterm Infants.
    Neonatology, 2016, Volume: 109, Issue:4

    Topics: Birth Weight; Bradycardia; Female; Gestational Age; Humans; Hypnotics and Sedatives; Hypotension; In

2016
Sedation during Minimal Invasive Surfactant Therapy in Preterm Infants.
    Neonatology, 2016, Volume: 109, Issue:4

    Topics: Birth Weight; Bradycardia; Female; Gestational Age; Humans; Hypnotics and Sedatives; Hypotension; In

2016
Sedation during Minimal Invasive Surfactant Therapy in Preterm Infants.
    Neonatology, 2016, Volume: 109, Issue:4

    Topics: Birth Weight; Bradycardia; Female; Gestational Age; Humans; Hypnotics and Sedatives; Hypotension; In

2016
Sedation during Minimal Invasive Surfactant Therapy in Preterm Infants.
    Neonatology, 2016, Volume: 109, Issue:4

    Topics: Birth Weight; Bradycardia; Female; Gestational Age; Humans; Hypnotics and Sedatives; Hypotension; In

2016
Deep Sedation for Pediatric Dental Procedures: Is this a Safe and Effective Option?
    The Journal of clinical pediatric dentistry, 2016, Volume: 40, Issue:2

    Topics: Adjuvants, Anesthesia; Anesthesia Recovery Period; Anesthesia, Dental; Anesthetics, Intravenous; Cat

2016
Safety and clinical effectiveness of propofol for endoscopic retrograde cholangiopancreatography.
    European journal of internal medicine, 2016, Volume: 32

    Topics: Anesthetics, Intravenous; Cholangiopancreatography, Endoscopic Retrograde; Cholangitis; Choledocholi

2016
Ultrasound measurement of inferior vena cava collapse predicts propofol-induced hypotension.
    The American journal of emergency medicine, 2016, Volume: 34, Issue:6

    Topics: Aged; Anesthetics, Intravenous; Female; Humans; Hypotension; Male; Middle Aged; Predictive Value of

2016
Propofol sedation administered by cardiologists for patients undergoing catheter ablation for ventricular tachycardia.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2016, Volume: 18, Issue:8

    Topics: Aged; Blood Pressure; Cardiologists; Catheter Ablation; Defibrillators, Implantable; Female; Germany

2016
Safety of Target-Controlled Propofol Infusion by Gastroenterologists in Patients Undergoing Endoscopic Resection.
    Digestive diseases and sciences, 2016, Volume: 61, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Algorithms; Anesthetics, Intravenous; Case-Control Studies; Deep Sed

2016
Effects of propofol on vasopressor use in patients with sepsis and severe sepsis: A pilot study.
    Journal of critical care, 2016, Volume: 35

    Topics: Aged; Anesthetics, Intravenous; Blood Pressure; Female; Hospital Mortality; Humans; Hypnotics and Se

2016
Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice.
    Journal of clinical anesthesia, 2016, Volume: 33

    Topics: Adult; Aged; Aged, 80 and over; Aging; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous

2016
A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients?
    Drugs & aging, 2016, Volume: 33, Issue:10

    Topics: Adolescent; Adult; Age Factors; Aged; Anesthesia, General; Anesthetics, Intravenous; Blood Pressure;

2016
Ultrasound Measurement Of Inferior Vena Cava Collapse Predicts Propofol Induced Hypotension.
    The American journal of emergency medicine, 2017, Volume: 35, Issue:3

    Topics: Humans; Hypotension; Hypotension, Controlled; Propofol; Shock; Vena Cava, Inferior

2017
Flexible bronchoscopy with moderate sedation in COPD: a case-control study.
    International journal of chronic obstructive pulmonary disease, 2017, Volume: 12

    Topics: Adult; Aged; Anesthetics, Intravenous; Bronchoscopy; Case-Control Studies; Conscious Sedation; Femal

2017
Atypical presentation to rocuronium allergy in a 19-year-old female patient.
    Journal of clinical anesthesia, 2017, Volume: 37

    Topics: Adult; Anaphylaxis; Androstanols; Anesthesia, General; Anesthetics, Intravenous; Cardiopulmonary Res

2017
Low pre-operative heart rate variability and complexity are associated with hypotension after anesthesia induction in major abdominal surgery.
    Journal of clinical monitoring and computing, 2018, Volume: 32, Issue:2

    Topics: Abdomen; Aged; Algorithms; Anesthesia; Anesthesia, General; Autonomic Nervous System; Cohort Studies

2018
Low pre-operative heart rate variability and complexity are associated with hypotension after anesthesia induction in major abdominal surgery.
    Journal of clinical monitoring and computing, 2018, Volume: 32, Issue:2

    Topics: Abdomen; Aged; Algorithms; Anesthesia; Anesthesia, General; Autonomic Nervous System; Cohort Studies

2018
Low pre-operative heart rate variability and complexity are associated with hypotension after anesthesia induction in major abdominal surgery.
    Journal of clinical monitoring and computing, 2018, Volume: 32, Issue:2

    Topics: Abdomen; Aged; Algorithms; Anesthesia; Anesthesia, General; Autonomic Nervous System; Cohort Studies

2018
Low pre-operative heart rate variability and complexity are associated with hypotension after anesthesia induction in major abdominal surgery.
    Journal of clinical monitoring and computing, 2018, Volume: 32, Issue:2

    Topics: Abdomen; Aged; Algorithms; Anesthesia; Anesthesia, General; Autonomic Nervous System; Cohort Studies

2018
Bradycardia, hypotension and bronchospasm following remifentanil-propofol in a myathenic paitent treated by pyridostigmine--a case report.
    Middle East journal of anaesthesiology, 2008, Volume: 19, Issue:6

    Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Bradycardia; Bronchial Spasm; Cholinesterase I

2008
Predictors of hemodynamic compromise with propofol during defibrillator implantation: a single center experience.
    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2009, Volume: 25, Issue:2

    Topics: Aged; Conscious Sedation; Defibrillators, Implantable; Female; Humans; Hypotension; Incidence; Male;

2009
Frontal lobe oxygenation is maintained during hypotension following propofol-fentanyl anesthesia.
    AANA journal, 2009, Volume: 77, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anesthetics, Intravenous; Cerebrov

2009
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
Pleth variability index predicts hypotension during anesthesia induction.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:5

    Topics: Algorithms; Anesthetics, Intravenous; Blood Pressure; Female; Heart Rate; Humans; Hypotension; Male;

2010
The intravenous anesthetic propofol inhibits human L-type calcium channels by enhancing voltage-dependent inactivation.
    Journal of clinical pharmacology, 2011, Volume: 51, Issue:5

    Topics: Anesthetics, Intravenous; Atrial Appendage; Bradycardia; Calcium Channel Blockers; Calcium Channels,

2011
A comparison of anesthetic complications between diabetic and nondiabetic dogs undergoing phacoemulsification cataract surgery: a retrospective study.
    Veterinary ophthalmology, 2010, Volume: 13, Issue:4

    Topics: Acepromazine; Anesthesia, Intravenous; Animals; Bradycardia; Cataract; Diabetes Mellitus; Dog Diseas

2010
Propofol as an induction agent for endotracheal intubation can cause significant arterial hypotension in preterm neonates.
    Paediatric anaesthesia, 2010, Volume: 20, Issue:7

    Topics: Anesthetics, Intravenous; Blood Pressure; Humans; Hypotension; Infant; Infant, Newborn; Infant, Prem

2010
High BMI in children as a risk factor for intraoperative hypotension.
    European journal of anaesthesiology, 2010, Volume: 27, Issue:12

    Topics: Adolescent; Age Factors; Anesthesia, General; Anesthetics, Intravenous; Body Mass Index; Child; Chil

2010
Severe cerebral desaturation during shoulder arthroscopy in the beach-chair position.
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2010, Volume: 26, Issue:9 Suppl

    Topics: Anesthesia, General; Arthroscopy; Blood Gas Monitoring, Transcutaneous; Brain Ischemia; Cerebrovascu

2010
The influence of duration of fluid abstinence on hypotension during propofol induction.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:6

    Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Blood Pressure; Consciousness Monitors; Dose-Resp

2010
Evaluation of dexmedetomidine versus propofol-based sedation therapy in mechanically ventilated cardiac surgery patients at a tertiary academic medical center.
    Critical pathways in cardiology, 2010, Volume: 9, Issue:4

    Topics: Aged; Aged, 80 and over; Cardiac Surgical Procedures; Clinical Protocols; Dexmedetomidine; Female; H

2010
Safety of continuous propofol sedation for endoscopic procedures in elderly patients.
    Revista espanola de enfermedades digestivas, 2011, Volume: 103, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bradycardia; Colonoscopy; Conscious Sedation; Electroenc

2011
Propofol infusion syndrome--a critical incident report highlighting the danger of reexposure.
    Journal of neurosurgical anesthesiology, 2011, Volume: 23, Issue:3

    Topics: Adult; Arrhythmias, Cardiac; Head Injuries, Closed; Humans; Hypnotics and Sedatives; Hypotension; In

2011
Case scenario: bronchospasm during anesthetic induction.
    Anesthesiology, 2011, Volume: 114, Issue:5

    Topics: Adult; Albuterol; Anesthesia; Anesthetics, Intravenous; Anti-Inflammatory Agents; Bronchial Spasm; B

2011
Evaluation of dexmedetomidine: safety and clinical outcomes in critically ill trauma patients.
    The Journal of trauma, 2011, Volume: 71, Issue:5

    Topics: Adult; Analgesics; Antipsychotic Agents; Chi-Square Distribution; Critical Illness; Dexmedetomidine;

2011
Propofol as an induction agent for endotracheal intubation can cause significant arterial hypotension in preterm infants.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:6

    Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pressure; Gestational Age; Humans; Hypotens

2011
Adverse events during monitored anesthesia care for GI endoscopy: an 8-year experience.
    Gastrointestinal endoscopy, 2011, Volume: 74, Issue:2

    Topics: Adolescent; Age Factors; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Body Mass Index; Bradyca

2011
Nurse-administered propofol sedation for endoscopy: a risk analysis during an implementation phase.
    Endoscopy, 2011, Volume: 43, Issue:8

    Topics: Adult; Aged; Cholangiopancreatography, Endoscopic Retrograde; Clinical Competence; Deep Sedation; Ed

2011
A retrospective analysis of proceduralist-directed, nurse-administered propofol sedation for implantable cardioverter-defibrillator procedures.
    Heart rhythm, 2012, Volume: 9, Issue:3

    Topics: Aged; Anesthetics, Intravenous; Cardiac Pacing, Artificial; Conscious Sedation; Defibrillators, Impl

2012
Propofol sedation administered by cardiologists without assisted ventilation for long cardiac interventions: an assessment of 1000 consecutive patients undergoing atrial fibrillation ablation.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2012, Volume: 14, Issue:3

    Topics: Aged; Anesthetics, Intravenous; Atrial Fibrillation; Cardiac Tamponade; Catheter Ablation; Cohort St

2012
Propofol sedation administered by cardiologists without assisted ventilation for long cardiac interventions: an assessment of 1000 consecutive patients undergoing atrial fibrillation ablation.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2012, Volume: 14, Issue:3

    Topics: Aged; Anesthetics, Intravenous; Atrial Fibrillation; Cardiac Tamponade; Catheter Ablation; Cohort St

2012
Propofol sedation administered by cardiologists without assisted ventilation for long cardiac interventions: an assessment of 1000 consecutive patients undergoing atrial fibrillation ablation.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2012, Volume: 14, Issue:3

    Topics: Aged; Anesthetics, Intravenous; Atrial Fibrillation; Cardiac Tamponade; Catheter Ablation; Cohort St

2012
Propofol sedation administered by cardiologists without assisted ventilation for long cardiac interventions: an assessment of 1000 consecutive patients undergoing atrial fibrillation ablation.
    Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2012, Volume: 14, Issue:3

    Topics: Aged; Anesthetics, Intravenous; Atrial Fibrillation; Cardiac Tamponade; Catheter Ablation; Cohort St

2012
Nurse-administered propofol sedation for gastrointestinal endoscopic procedures: first Nordic results from implementation of a structured training program.
    Scandinavian journal of gastroenterology, 2011, Volume: 46, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Clinical Competence; Deep Sedation; Educ

2011
Obesity as a risk factor for sedation-related complications during propofol-mediated sedation for advanced endoscopic procedures.
    Gastrointestinal endoscopy, 2011, Volume: 74, Issue:6

    Topics: Aged; Anesthetics, Intravenous; Body Mass Index; Conscious Sedation; Digestive System Diseases; Endo

2011
Opioid receptor blockade prevents propofol-induced hypotension in rats.
    Journal of neurosurgical anesthesiology, 2012, Volume: 24, Issue:3

    Topics: Anesthetics, Intravenous; Animals; Blood Pressure; Hypotension; Naloxone; Narcotic Antagonists; Prop

2012
Effects of propofol with hyperthermia in a rat model of endotoxemic shock.
    Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:7

    Topics: Acidosis; Animals; Carbon Dioxide; Combined Modality Therapy; Cytokines; Drug Evaluation, Preclinica

2012
Induction dose of propofol for pediatric patients undergoing procedural sedation in the emergency department.
    Pediatric emergency care, 2012, Volume: 28, Issue:5

    Topics: Adolescent; Anesthetics, Intravenous; Child; Child, Preschool; Conscious Sedation; Dose-Response Rel

2012
Haemodynamics and cerebral oxygenation during arthroscopic shoulder surgery in beach chair position under general anaesthesia.
    Acta anaesthesiologica Scandinavica, 2012, Volume: 56, Issue:7

    Topics: Aged; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation;

2012
Endoscopist-administered propofol sedation is safe - a prospective evaluation of 10,000 patients in an outpatient practice.
    Journal of gastrointestinal and liver diseases : JGLD, 2012, Volume: 21, Issue:3

    Topics: Ambulatory Care; Bradycardia; Colonoscopy; Endoscopy, Gastrointestinal; Female; Humans; Hypnotics an

2012
Perioperative plasma concentrations of atrial and brain natriuretic peptides in patients undergoing hip arthroplasty.
    Anaesthesia and intensive care, 2002, Volume: 30, Issue:5

    Topics: Aged; Aged, 80 and over; Analysis of Variance; Anesthesia, Intravenous; Anesthetics, Combined; Arthr

2002
General anesthesia or sedation in the intensive care unit: are we aware of the difference when we use propofol?
    Critical care medicine, 2003, Volume: 31, Issue:5

    Topics: Anesthesia, General; Anesthetics, Intravenous; Apnea; Child; Conscious Sedation; Critical Care; Drug

2003
The effect of sevoflurane and propofol on cerebral neurotransmitter concentrations during cerebral ischemia in rats.
    Anesthesia and analgesia, 2003, Volume: 97, Issue:4

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Aspartic Acid; Blood Gas Analysis; Blood

2003
[Severe hypotension after induction of general anesthesia in a patient receiving an angiotensin II receptor antagonist and an alpha-blocker].
    Masui. The Japanese journal of anesthesiology, 2005, Volume: 54, Issue:6

    Topics: Adrenergic alpha-Antagonists; Anesthesia, General; Angiotensin II Type 1 Receptor Blockers; Antihype

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Improved haemodynamics with sevoflurane in laminectomy in a child with Rubinstein-Taybi syndrome.
    Anaesthesia and intensive care, 2005, Volume: 33, Issue:5

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Child; Humans; Hypotension; Intraoperative Compli

2005
Propofol for emergency department procedural sedation and analgesia: a tale of three centers.
    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 2006, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Antiemetics; Child; Child, Preschool; Conscio

2006
[Anesthetic management with propofol for pheochromocytoma resection under monitoring of bispectral index and blood volume].
    Masui. The Japanese journal of anesthesiology, 2006, Volume: 55, Issue:1

    Topics: Adrenal Gland Neoplasms; Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Volume Dete

2006
Recommendations for postinduction hypotension: are they supported by the evidence?
    Anesthesia and analgesia, 2006, Volume: 102, Issue:5

    Topics: Anesthesia, Intravenous; Blood Pressure; Health Planning Guidelines; Humans; Hypotension; Hypovolemi

2006
Hemodynamics with propofol: is propofol dangerous in classes III-V patients?
    Anesthesia and analgesia, 2006, Volume: 103, Issue:1

    Topics: Anesthetics, Intravenous; Hemodynamics; Humans; Hypotension; Propofol

2006
Propofol by infusion protocol for ED procedural sedation.
    The American journal of emergency medicine, 2006, Volume: 24, Issue:5

    Topics: Adolescent; Adult; Aged; Clinical Protocols; Conscious Sedation; Delusions; Dose-Response Relationsh

2006
Procedural sedation and analgesia in a Canadian adult tertiary care emergency department: a case series.
    CJEM, 2006, Volume: 8, Issue:2

    Topics: Age Distribution; Aged; Canada; Conscious Sedation; Drug Therapy, Combination; Drug Utilization; Eme

2006
Emergency department procedural sedation and analgesia: A Canadian Community Effectiveness and Safety Study (ACCESS).
    CJEM, 2006, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Age Factors; Aged; Apnea; Blood Gas Monitoring, Transcutaneous; Bradycardia; Cana

2006
Influence of cisatracurium on entropy values during propofol-remifentanil anesthesia.
    Anesthesia and analgesia, 2007, Volume: 104, Issue:1

    Topics: Aged; Anesthesia, Intravenous; Atracurium; Electromyography; Entropy; Ephedrine; Humans; Hypotension

2007
Intravenous propofol precipitates the hypotension induced by inadvertent epidural thiopental injection.
    Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2006, Volume: 44, Issue:4

    Topics: Aged; Anesthetics, Intravenous; Drug Synergism; Humans; Hypotension; Injections, Epidural; Male; Med

2006
Early propofol infusion syndrome following cerebral angiographic embolization for giant aneurysm repair. Case report.
    Journal of neurosurgery, 2007, Volume: 106, Issue:2 Suppl

    Topics: Acidosis; Anesthetics, Intravenous; Aneurysm; Balloon Occlusion; Cardiac Output, Low; Carotid Artery

2007
[Anesthesia for laparoscopic adrenalectomy in a pregnant patient with Cushing syndrome].
    Revista espanola de anestesiologia y reanimacion, 2007, Volume: 54, Issue:4

    Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenalectomy; Anesthesia, Intravenous; Anesthetics, Intravenous;

2007
Efficacy, safety and patient satisfaction of propofol for procedural sedation and analgesia in the emergency department: a prospective study.
    CJEM, 2007, Volume: 9, Issue:6

    Topics: Conscious Sedation; Emergency Service, Hospital; Female; Humans; Hypnotics and Sedatives; Hypotensio

2007
Efficacy, safety and patient satisfaction of propofol for procedural sedation and analgesia in the emergency department: a prospective study.
    CJEM, 2007, Volume: 9, Issue:6

    Topics: Conscious Sedation; Emergency Service, Hospital; Female; Humans; Hypnotics and Sedatives; Hypotensio

2007
Efficacy, safety and patient satisfaction of propofol for procedural sedation and analgesia in the emergency department: a prospective study.
    CJEM, 2007, Volume: 9, Issue:6

    Topics: Conscious Sedation; Emergency Service, Hospital; Female; Humans; Hypnotics and Sedatives; Hypotensio

2007
Efficacy, safety and patient satisfaction of propofol for procedural sedation and analgesia in the emergency department: a prospective study.
    CJEM, 2007, Volume: 9, Issue:6

    Topics: Conscious Sedation; Emergency Service, Hospital; Female; Humans; Hypnotics and Sedatives; Hypotensio

2007
Hypotension in anaesthetized patients during aneurysm clipping: not as bad as expected?
    Acta anaesthesiologica Scandinavica, 2008, Volume: 52, Issue:7

    Topics: Anesthesia; Anesthetics, Intravenous; Anesthetics, Local; Atracurium; Cohort Studies; Etomidate; Fem

2008
Inhibitory effects of propofol on catecholamine secretion and uptake in cultured bovine adrenal medullary cells.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 353, Issue:5

    Topics: Adrenal Medulla; Anesthetics, Intravenous; Animals; Blood Pressure; Calcium; Carbachol; Cattle; Cell

1996
Prevention of hypotension after propofol for rapid sequence intubation.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:8

    Topics: Anesthetics, Intravenous; Humans; Hypotension; Propofol

1996
Propofol inhibits medullary pressor mechanisms in cats.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1997, Volume: 44, Issue:7

    Topics: Anesthetics, Intravenous; Animals; Arteries; Blood Pressure; Cats; Dose-Response Relationship, Drug;

1997
The effect of rate of administration on brain concentrations of propofol in sheep.
    Anesthesia and analgesia, 1998, Volume: 86, Issue:6

    Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Area Under Curve; Brain; Cerebrovascular

1998
Effects of target-controlled anesthesia with propofol and sufentanil on the hemodynamic response to Mayfield head holder application.
    Acta anaesthesiologica Belgica, 1998, Volume: 49, Issue:1

    Topics: Adjuvants, Anesthesia; Alprazolam; Analysis of Variance; Anesthesia, Intravenous; Anesthetics, Intra

1998
Anaphylactoid reaction induced by pancuronium during general anaesthesia.
    European journal of anaesthesiology, 1998, Volume: 15, Issue:5

    Topics: Aged; Anaphylaxis; Anesthesia, Intravenous; Anesthetics, Intravenous; Bronchial Spasm; Humans; Hypot

1998
Propofol anesthesia for invasive procedures in ambulatory and hospitalized children: experience in the pediatric intensive care unit.
    Pediatrics, 1999, Volume: 103, Issue:3

    Topics: Adult; Age Factors; Ambulatory Surgical Procedures; Anesthesia, Intravenous; Anesthetics, Intravenou

1999
The haemodynamic effects of propofol in combination with ephedrine in elderly patients (ASA groups 3 and 4).
    Anaesthesia and intensive care, 1999, Volume: 27, Issue:5

    Topics: Adrenergic Agents; Aged; Anesthetics, Intravenous; Blood Pressure; Ephedrine; Heart Rate; Hemodynami

1999
Disposition of propofol between red blood cells, plasma, brain and cerebrospinal fluid in rabbits.
    European journal of anaesthesiology, 2000, Volume: 17, Issue:1

    Topics: Acidosis; Analysis of Variance; Anesthesia Recovery Period; Anesthetics, Intravenous; Animals; Brain

2000
Prospective evaluation of propofol anesthesia in the pediatric intensive care unit for elective oncology procedures in ambulatory and hospitalized children.
    Pediatrics, 2000, Volume: 106, Issue:4

    Topics: Adolescent; Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Biopsy, Needle; Bone Marrow Ex

2000
Propofol or thiopentone as induction agents in romifidine-sedated and halothane-N2O-anesthetized dogs: a preliminary study.
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2000, Volume: 64, Issue:4

    Topics: Anesthesia, General; Anesthetics; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Dogs;

2000
[Premedication and sedation complications during ophthalmic anesthesia].
    Journal francais d'ophtalmologie, 2000, Volume: 23, Issue:9

    Topics: Adjuvants, Anesthesia; Alfentanil; Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anesthesi

2000
Bronchoscopy with bronchoalveolar lavage via the laryngeal mask airway in high-risk hypoxemic immunosuppressed patients.
    Critical care medicine, 2001, Volume: 29, Issue:2

    Topics: Aged; Anesthetics, Intravenous; Blood Gas Analysis; Bronchoalveolar Lavage; Bronchoscopy; Contraindi

2001
[Carotid endarterectomy under remifentanil].
    Revista espanola de anestesiologia y reanimacion, 2001, Volume: 48, Issue:10

    Topics: Aged; Aged, 80 and over; Alprazolam; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetic

2001
Sedation for endoscopy: the safe use of propofol by general practitioner sedationists.
    The Medical journal of Australia, 2002, Feb-18, Volume: 176, Issue:4

    Topics: Anesthetics, Combined; Anesthetics, Intravenous; Australia; Colonoscopy; Family Practice; Fentanyl;

2002
Arterial baroreflex attenuation during and after continuous propofol infusion.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:9

    Topics: Animals; Arteries; Blood Pressure; Heart Rate; Hypertension; Hypotension; Infusions, Intravenous; In

1992
Amiodarone and anaesthesia: concurrent therapy with ACE inhibitors--an additional cause for concern?
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1991, Volume: 38, Issue:5

    Topics: Adult; Amiodarone; Anesthesia, Intravenous; Enalapril; Fentanyl; Humans; Hypotension; Male; Midazola

1991
Exaggerated physiological responses to propofol in myotonic dystrophy.
    British journal of anaesthesia, 1990, Volume: 64, Issue:6

    Topics: Anesthesia, General; Humans; Hypotension; Myotonic Dystrophy; Propofol; Surgical Procedures, Operati

1990
Propofol: a new intravenous anaesthetic.
    The West Indian medical journal, 1988, Volume: 37, Issue:4

    Topics: Adolescent; Adult; Aged; Anesthesia, Intravenous; Apnea; Female; Humans; Hypotension; Middle Aged; P

1988