propofol and Hip Fractures

propofol has been researched along with Hip Fractures in 16 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Hip Fractures: Fractures of the FEMUR HEAD; the FEMUR NECK; (FEMORAL NECK FRACTURES); the trochanters; or the inter- or subtrochanteric region. Excludes fractures of the acetabulum and fractures of the femoral shaft below the subtrochanteric region (FEMORAL FRACTURES).

Research

Studies (16)

Authors

Clinical Trials (9)

Trial Overview

Trial Outcomes

Change in Functional Status

Ability to perform Activities of Daily Living (ADL) using 6-point Katz activities of daily living scale, assessed at 12 months post-op. The range of the Katz activities of daily living scale is from 0-6, 0 is worse and 6 is best. (NCT00590707)
Timeframe: 12 months post-operative

Clinical Dementia Rating Sum of Boxes (CDR-SOB) Score

"Clinical Dementia Rating consists of 6 domains (boxes) of function: memory, orientation, judgment and problem solving, community affairs, home and hobbies, and personal care. Each domain (box) is rated on a 5-point scale (0= no impairment, 0.5=questionable impairment, 1= mild impairment, 2= moderated impairment, 3= severe impairment. The CDR-SOB score is a sum of these ratings, for a total Sum of boxes ranging from 0-18, where 0=cognitively intact. Increasing sum of boxes score is associated with greater cognitive impairment." (NCT00590707)
Timeframe: 12 months post-operative

Mortality

death occurring during follow-up period, in one year post-op. (NCT00590707)
Timeframe: 12 months post-operative

Number of Participants With the Presence of Delirium as Assessed by the Confusion Assessment Method

The presence of delirium is assessed by the confusion assessment method (CAM), during postoperative Day 1 to Day 5 or up to hospital discharge, whichever occurs first. The CAM consists of 4 features: 1-Onset, 2-Inattention, 3-Disorganized thinking, and 4-altered level of consciousness. The diagnosis of delirium by CAM is based on the presence of features 1 and 2, and either 3 or 4. (NCT00590707)
Timeframe: Postoperative days up to hospital discharge

Number of Participants With the Presence of Delirium at 1 Month as Assessed by the Confusion Assessment Method

The presence of delirium is assessed by the confusion assessment method (CAM), after 1 month postoperative. The CAM consists of 4 features: 1-Onset, 2-Inattention, 3-Disorganized thinking, and 4-altered level of consciousness. The diagnosis of delirium by CAM is based on the presence of features 1 and 2, and either 3 or 4. (NCT00590707)
Timeframe: 1 month (30 days) post-intervention

Circulation Stability

number of participants with need for application of ephedrine and/or norepinephrine (NCT04005404)
Timeframe: during surgery

Success Rate (Conversion to General Anesthesia)

number of participants with need for conversion to general anesthesia (NCT04005404)
Timeframe: during surgery

Success Rate (Supplemental Medication)

number of participants with need for supplemental analgesic medication (sufentanil) (NCT04005404)
Timeframe: during surgery

Number of Participants With Postoperative Delirium After Hip Fracture Surgery

Delirium will be assessed by the Confusion Assessment Method Instrument (CAM), a validated method of assessing delirium based on the presence of both (1) an acute onset of signs and symptoms with a fluctuating course AND (2) inattention; PLUS (3) disorganized thinking OR (4) an altered level of consciousness. (NCT02190903)
Timeframe: Up to 5 days post hip fracture surgery

30 Day Mortality

Mortality within 30 days post operation (NCT02213380)
Timeframe: 30 days after surgery

Acute Pain Score Using Visual Analogue Scale (VAS)

The worst pain score within 7 days post-operation in both groups. The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between no pain(0 point) to worst pain (100 points). (NCT02213380)
Timeframe: In 7days post operation

Costs of Anesthetic Procedure

Costs of anesthetic procedure only (NCT02213380)
Timeframe: 1 day after operation

Length of Hospital Stay

Length of hospital stay are measured from the anesthesia starting day to the discharge day (NCT02213380)
Timeframe: till the day of discharge from hospital, an average of 7 days

Number of Participants With Post-operative Delirium in 7 Days Post Operation

Post-operative delirium diagnosed with Confusion Assessment Method (NCT02213380)
Timeframe: in 7 days post operation

Severity of Delirium

The worst severity scores of delirium was diagnosed with the DRS-R-98 within 7 days (NCT02213380)
Timeframe: within first 7days post operation

Total In-hospital Costs

Entire expenditure in-hospital (NCT02213380)
Timeframe: till the day of discharge

Postoperative Hospital Stay

Duration of postoperative hospital stay in days (NCT02848599)
Timeframe: 14 days

Changes in C-reactive Protein (CRP) Levels

Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery

Changes in Cognitive Function

"Assessment of cognitive function will be done using the Mini-mental state examination (MMSE) rating scales before and 24,48,72,96 and 120 hours after the surgery at the same time every morning.~Mini-Mental State Examination Scale: minimum score is 0 and maximum score is 30; the severity of cognitive impairment: no cognitive impairment=25-30; mild cognitive impairment=19-24; moderate cognitive impairment=10-18; and severe cognitive impairment<9. Higher scores mean a better and lower scores mean a worse outcome." (NCT02848599)
Timeframe: Before, 24,48,72,96 and 120 hours after the surgery

Changes in Fibrinogen Concentrations in Peripheral Blood

Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery

Changes in Pain Intensity

"Assessment will be done using Numeric Rating Scale (NRS). During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily. Median of 8 time points measurements during the first 24, 48 and 72 hours after the surgery will be reported. After that, median of 3 time points will be reported from the 4. to 6. postoperative day and on the day of discharge.~Minimum score 0 and maximum score 10 ( 0-No Pain; 1-3 Mild Pain; 4-6 Moderate Pain; 7-10 Severe Pain ). Higher scores mean a worse and lower scores mean a better outcome." (NCT02848599)
Timeframe: During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily until discharge

Interleukin-6 Concentration in Peripheral Blood.

Measurement will be done before and 24 and 72 hours after the surgery. (NCT02848599)
Timeframe: Before, 24 and 72 hours after the surgery

Incidence of Complications (e.g. Frequency of Foot-drop).

"Complications such as drug toxicity, arrhythmia, bradycardia, hematoma, Foot Drop, allergic reaction will be recorded" (NCT02161484)
Timeframe: 48 hours after the start of the surgery

Numeric Rating Scale (NRS) Pain Assessment

Postoperative pain assessments using a 11-point numerical rating during physical therapy and at rest. This pain scale ranges from 0, being no pain at all, up to 10 being the worst pain ever experience. (NCT02161484)
Timeframe: 24 hours after the start of surgery

Numeric Rating Scale (NRS) Pain Assessment

Postoperative pain assessments using a 11-point numerical rating during physical therapy and at rest. This pain scale ranges from 0, being no pain at all, up to 10 being the worst pain ever experience. (NCT02161484)
Timeframe: 48 hours after the start of surgery

Numeric Rating Scale (NRS) Pain Assessment

Postoperative pain assessments using a 11-point numerical rating during physical therapy and at rest. This pain scale ranges from 0, being no pain at all, up to 10 being the worst pain ever experience. (NCT02161484)
Timeframe: 6 hours after the start of surgery

Trials

5 trials available for propofol and Hip Fractures

Other Studies

11 other studies available for propofol and Hip Fractures