propofol has been researched along with Hemolysis in 17 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Free propofol concentration was also found to be 40% lesser than marketed formulation." | 1.51 | Nanostructured Lipid Carrier of Propofol: a Promising Alternative to Marketed Soybean Oil-Based Nanoemulsion. ( Pai, R; Shevalkar, G; Vavia, P, 2019) |
| "Patients with G6PD deficiency are prone to develop haemolysis following any kind of oxidative stress and in ACM, there is a disturbed cranio-spinal pressure relationship." | 1.43 | G6PD Deficiency with Arnold-Chiari Malformation. ( Bhatia, PK; Sethi, P; Sharma, V; Singh, YR; Verma, S, 2016) |
| " The pharmacokinetic profile for the microemulsion showed rapid distribution and elimination compared to Diprivan(®)." | 1.38 | A propofol microemulsion with low free propofol in the aqueous phase: formulation, physicochemical characterization, stability and pharmacokinetics. ( Cai, W; Chen, X; Deng, W; Jin, F; Yang, H, 2012) |
| "Propofol is a widely used anesthetic agent with highly desirable fast "on" and "off" effects." | 1.33 | A novel, lipid-free nanodispersion formulation of propofol and its characterization. ( Almarsson, O; Berkovitz, D; Chen, H; Gardner, CR; Marier, JF; Zhang, Z, 2005) |
| "Propofol itself was chosen as the oil phase and its content was fixed to 1%, w/w." | 1.33 | Development of propofol-loaded microemulsion systems for parenteral delivery. ( Chi, SC; Park, CW; Park, ES; Ryoo, HK, 2005) |
| "Propofol did not inhibit equilibrium exchange but did inhibit unidirectional efflux with little substrate dependence." | 1.31 | Inhibition of glucose transport and direct interactions with type 1 facilitative glucose transporter (GLUT-1) by etomidate, ketamine, and propofol: a comparison with barbiturates. ( Croxen, RL; El-Barbary, A; Fenstermacher, JD; Haspel, HC; Stephenson, KN, 2000) |
| "Propofol has free radical scavenging properties similar to those of recognized phenol-based antioxidants." | 1.29 | Effect of propofol and thiopentone on free radical mediated oxidative stress of the erythrocyte. ( Columb, MO; Davies, MJ; Murphy, PG; Stratford, N, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Negaard, BJ | 1 |
| Hobbs, R | 1 |
| Frye, JR | 1 |
| Merrill, AE | 1 |
| Shevalkar, G | 1 |
| Pai, R | 1 |
| Vavia, P | 1 |
| Sbrana, S | 1 |
| Nunziata, A | 1 |
| Storti, S | 1 |
| Haxhiademi, D | 1 |
| Mazzone, A | 1 |
| Leone, M | 1 |
| Solinas, M | 1 |
| Del Sarto, P | 1 |
| Pradhan, D | 1 |
| Sun, Q | 1 |
| Peck Palmer, OM | 1 |
| Verma, S | 1 |
| Bhatia, PK | 1 |
| Sharma, V | 1 |
| Sethi, P | 1 |
| Singh, YR | 1 |
| Shah, A | 1 |
| Mistry, B | 1 |
| Gibiansky, E | 1 |
| Gibiansky, L | 1 |
| Clare, H | 1 |
| Lin, PK | 1 |
| Tetley, L | 1 |
| Cheng, WP | 1 |
| Li, G | 1 |
| Fan, Y | 1 |
| Li, X | 1 |
| Wang, X | 1 |
| Li, Y | 1 |
| Liu, Y | 1 |
| Li, M | 1 |
| Cai, W | 1 |
| Deng, W | 1 |
| Yang, H | 1 |
| Chen, X | 1 |
| Jin, F | 1 |
| Chen, H | 1 |
| Zhang, Z | 1 |
| Almarsson, O | 1 |
| Marier, JF | 1 |
| Berkovitz, D | 1 |
| Gardner, CR | 1 |
| Ryoo, HK | 1 |
| Park, CW | 1 |
| Chi, SC | 1 |
| Park, ES | 1 |
| Murphy, PG | 1 |
| Davies, MJ | 1 |
| Columb, MO | 1 |
| Stratford, N | 2 |
| Gao, F | 1 |
| Harris, DN | 1 |
| Sapsed-Byrne, S | 1 |
| Sharp, S | 1 |
| Murphy, P | 1 |
| Stephenson, KN | 1 |
| Croxen, RL | 1 |
| El-Barbary, A | 1 |
| Fenstermacher, JD | 1 |
| Haspel, HC | 1 |
| Bernard, E | 1 |
| Schmid, ER | 1 |
| Schmidlin, D | 1 |
| Schaffner, A | 1 |
| Germann, R | 1 |
| Tsuchiya, M | 1 |
| Asada, A | 1 |
| Kasahara, E | 1 |
| Sato, EF | 1 |
| Shindo, M | 1 |
| Inoue, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Protective Effect of Propofol Against Hemolysis in Patients Submitted to Gastroplasty[NCT00792779] | 60 participants (Anticipated) | Interventional | 2008-11-30 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for propofol and Hemolysis
| Article | Year |
|---|---|
Antioxidant activity of propofol in blood from anaesthetized patients.
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Antioxidants; Erythrocytes; Female; Hemogl | 1998 |
Antioxidant protection of propofol and its recycling in erythrocyte membranes.
Topics: alpha-Tocopherol; Antioxidants; Ascorbic Acid; Drug Evaluation, Preclinical; Drug Synergism; Electro | 2002 |
15 other studies available for propofol and Hemolysis
| Article | Year |
|---|---|
Propofol-induced interference with activated partial thromboplastin time-based monitoring of therapeutic heparin anticoagulation.
Topics: Anticoagulants; Hemolysis; Heparin; Humans; Partial Thromboplastin Time; Propofol; Retrospective Stu | 2023 |
Nanostructured Lipid Carrier of Propofol: a Promising Alternative to Marketed Soybean Oil-Based Nanoemulsion.
Topics: Animals; Drug Carriers; Emulsions; Female; Hemolysis; Humans; Nanostructures; Particle Size; Propofo | 2019 |
Differential modulatory effects of Propofol and Sevoflurane anesthesia on blood monocyte HLA-DR and CD163 expression during and after cardiac surgery with cardiopulmonary bypass: a preliminary randomized flow cytometry study.
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Antigens, CD; Antigens, Differentiation, My | 2020 |
Lipidemia in the Setting of Hemolysis.
Topics: Adult; Color; Drug Stability; Emulsions; Hematologic Tests; Hemolysis; Humans; Hypertriglyceridemia; | 2016 |
G6PD Deficiency with Arnold-Chiari Malformation.
Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Arnold-Chiari Malformation; Cerebral | 2016 |
Fospropofol assay issues and impact on pharmacokinetic and pharmacodynamic evaluation.
Topics: Anesthetics, Intravenous; Animals; Biological Assay; Biotransformation; Drug Stability; Hemolysis; H | 2009 |
The use of nano polymeric self-assemblies based on novel amphiphilic polymers for oral hydrophobic drug delivery.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Caco-2 Cells; Cattle; Cell Survival; Choles | 2012 |
In vitro and in vivo evaluation of a simple microemulsion formulation for propofol.
Topics: Anesthetics, Intravenous; Animals; Drug Delivery Systems; Drug Stability; Electric Conductivity; Emu | 2012 |
A propofol microemulsion with low free propofol in the aqueous phase: formulation, physicochemical characterization, stability and pharmacokinetics.
Topics: Anesthetics, Intravenous; Animals; Chemistry, Pharmaceutical; Dogs; Emulsions; Erythrocytes; Female; | 2012 |
A novel, lipid-free nanodispersion formulation of propofol and its characterization.
Topics: Animals; Chemistry, Pharmaceutical; Hemolysis; Humans; Male; Motor Activity; Nanostructures; Propofo | 2005 |
Development of propofol-loaded microemulsion systems for parenteral delivery.
Topics: Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Stability; Emulsions; Hemolysis; Humans; Hypn | 2005 |
Effect of propofol and thiopentone on free radical mediated oxidative stress of the erythrocyte.
Topics: Adult; Anesthetics, Intravenous; Cell Culture Techniques; Erythrocytes; Female; Free Radical Scaveng | 1996 |
Neurone-specific enolase and Sangtec 100 assays during cardiac surgery: Part I--The effects of heparin, protamine and propofol.
Topics: Anesthetics, Intravenous; Anticoagulants; Blood Coagulation; Cardiopulmonary Bypass; Cerebrovascular | 1997 |
Inhibition of glucose transport and direct interactions with type 1 facilitative glucose transporter (GLUT-1) by etomidate, ketamine, and propofol: a comparison with barbiturates.
Topics: 3T3 Cells; Anesthetics; Animals; Biological Transport; Cell Membrane; Cells, Cultured; Erythrocytes; | 2000 |
Hemoglobin Zurich and cardiopulmonary bypass.
Topics: Anesthesia; Anesthetics, Intravenous; Antioxidants; Cardiopulmonary Bypass; Female; Heart Valve Pros | 2000 |