Page last updated: 2024-11-03

propofol and Hemolysis

propofol has been researched along with Hemolysis in 17 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.

Research Excerpts

ExcerptRelevanceReference
"Free propofol concentration was also found to be 40% lesser than marketed formulation."1.51Nanostructured Lipid Carrier of Propofol: a Promising Alternative to Marketed Soybean Oil-Based Nanoemulsion. ( Pai, R; Shevalkar, G; Vavia, P, 2019)
"Patients with G6PD deficiency are prone to develop haemolysis following any kind of oxidative stress and in ACM, there is a disturbed cranio-spinal pressure relationship."1.43G6PD Deficiency with Arnold-Chiari Malformation. ( Bhatia, PK; Sethi, P; Sharma, V; Singh, YR; Verma, S, 2016)
" The pharmacokinetic profile for the microemulsion showed rapid distribution and elimination compared to Diprivan(®)."1.38A propofol microemulsion with low free propofol in the aqueous phase: formulation, physicochemical characterization, stability and pharmacokinetics. ( Cai, W; Chen, X; Deng, W; Jin, F; Yang, H, 2012)
"Propofol is a widely used anesthetic agent with highly desirable fast "on" and "off" effects."1.33A novel, lipid-free nanodispersion formulation of propofol and its characterization. ( Almarsson, O; Berkovitz, D; Chen, H; Gardner, CR; Marier, JF; Zhang, Z, 2005)
"Propofol itself was chosen as the oil phase and its content was fixed to 1%, w/w."1.33Development of propofol-loaded microemulsion systems for parenteral delivery. ( Chi, SC; Park, CW; Park, ES; Ryoo, HK, 2005)
"Propofol did not inhibit equilibrium exchange but did inhibit unidirectional efflux with little substrate dependence."1.31Inhibition of glucose transport and direct interactions with type 1 facilitative glucose transporter (GLUT-1) by etomidate, ketamine, and propofol: a comparison with barbiturates. ( Croxen, RL; El-Barbary, A; Fenstermacher, JD; Haspel, HC; Stephenson, KN, 2000)
"Propofol has free radical scavenging properties similar to those of recognized phenol-based antioxidants."1.29Effect of propofol and thiopentone on free radical mediated oxidative stress of the erythrocyte. ( Columb, MO; Davies, MJ; Murphy, PG; Stratford, N, 1996)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (17.65)18.2507
2000's6 (35.29)29.6817
2010's6 (35.29)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Negaard, BJ1
Hobbs, R1
Frye, JR1
Merrill, AE1
Shevalkar, G1
Pai, R1
Vavia, P1
Sbrana, S1
Nunziata, A1
Storti, S1
Haxhiademi, D1
Mazzone, A1
Leone, M1
Solinas, M1
Del Sarto, P1
Pradhan, D1
Sun, Q1
Peck Palmer, OM1
Verma, S1
Bhatia, PK1
Sharma, V1
Sethi, P1
Singh, YR1
Shah, A1
Mistry, B1
Gibiansky, E1
Gibiansky, L1
Clare, H1
Lin, PK1
Tetley, L1
Cheng, WP1
Li, G1
Fan, Y1
Li, X1
Wang, X1
Li, Y1
Liu, Y1
Li, M1
Cai, W1
Deng, W1
Yang, H1
Chen, X1
Jin, F1
Chen, H1
Zhang, Z1
Almarsson, O1
Marier, JF1
Berkovitz, D1
Gardner, CR1
Ryoo, HK1
Park, CW1
Chi, SC1
Park, ES1
Murphy, PG1
Davies, MJ1
Columb, MO1
Stratford, N2
Gao, F1
Harris, DN1
Sapsed-Byrne, S1
Sharp, S1
Murphy, P1
Stephenson, KN1
Croxen, RL1
El-Barbary, A1
Fenstermacher, JD1
Haspel, HC1
Bernard, E1
Schmid, ER1
Schmidlin, D1
Schaffner, A1
Germann, R1
Tsuchiya, M1
Asada, A1
Kasahara, E1
Sato, EF1
Shindo, M1
Inoue, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Protective Effect of Propofol Against Hemolysis in Patients Submitted to Gastroplasty[NCT00792779]60 participants (Anticipated)Interventional2008-11-30Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for propofol and Hemolysis

ArticleYear
Antioxidant activity of propofol in blood from anaesthetized patients.
    European journal of anaesthesiology, 1998, Volume: 15, Issue:2

    Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Antioxidants; Erythrocytes; Female; Hemogl

1998
Antioxidant protection of propofol and its recycling in erythrocyte membranes.
    American journal of respiratory and critical care medicine, 2002, Jan-01, Volume: 165, Issue:1

    Topics: alpha-Tocopherol; Antioxidants; Ascorbic Acid; Drug Evaluation, Preclinical; Drug Synergism; Electro

2002

Other Studies

15 other studies available for propofol and Hemolysis

ArticleYear
Propofol-induced interference with activated partial thromboplastin time-based monitoring of therapeutic heparin anticoagulation.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2023, 03-21, Volume: 80, Issue:7

    Topics: Anticoagulants; Hemolysis; Heparin; Humans; Partial Thromboplastin Time; Propofol; Retrospective Stu

2023
Nanostructured Lipid Carrier of Propofol: a Promising Alternative to Marketed Soybean Oil-Based Nanoemulsion.
    AAPS PharmSciTech, 2019, May-28, Volume: 20, Issue:5

    Topics: Animals; Drug Carriers; Emulsions; Female; Hemolysis; Humans; Nanostructures; Particle Size; Propofo

2019
Differential modulatory effects of Propofol and Sevoflurane anesthesia on blood monocyte HLA-DR and CD163 expression during and after cardiac surgery with cardiopulmonary bypass: a preliminary randomized flow cytometry study.
    Perfusion, 2020, Volume: 35, Issue:1

    Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Antigens, CD; Antigens, Differentiation, My

2020
Lipidemia in the Setting of Hemolysis.
    Clinical chemistry, 2016, Volume: 62, Issue:11

    Topics: Adult; Color; Drug Stability; Emulsions; Hematologic Tests; Hemolysis; Humans; Hypertriglyceridemia;

2016
G6PD Deficiency with Arnold-Chiari Malformation.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2016, Volume: 26, Issue:11

    Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Arnold-Chiari Malformation; Cerebral

2016
Fospropofol assay issues and impact on pharmacokinetic and pharmacodynamic evaluation.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:1

    Topics: Anesthetics, Intravenous; Animals; Biological Assay; Biotransformation; Drug Stability; Hemolysis; H

2009
The use of nano polymeric self-assemblies based on novel amphiphilic polymers for oral hydrophobic drug delivery.
    Pharmaceutical research, 2012, Volume: 29, Issue:3

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Caco-2 Cells; Cattle; Cell Survival; Choles

2012
In vitro and in vivo evaluation of a simple microemulsion formulation for propofol.
    International journal of pharmaceutics, 2012, Apr-04, Volume: 425, Issue:1-2

    Topics: Anesthetics, Intravenous; Animals; Drug Delivery Systems; Drug Stability; Electric Conductivity; Emu

2012
A propofol microemulsion with low free propofol in the aqueous phase: formulation, physicochemical characterization, stability and pharmacokinetics.
    International journal of pharmaceutics, 2012, Oct-15, Volume: 436, Issue:1-2

    Topics: Anesthetics, Intravenous; Animals; Chemistry, Pharmaceutical; Dogs; Emulsions; Erythrocytes; Female;

2012
A novel, lipid-free nanodispersion formulation of propofol and its characterization.
    Pharmaceutical research, 2005, Volume: 22, Issue:3

    Topics: Animals; Chemistry, Pharmaceutical; Hemolysis; Humans; Male; Motor Activity; Nanostructures; Propofo

2005
Development of propofol-loaded microemulsion systems for parenteral delivery.
    Archives of pharmacal research, 2005, Volume: 28, Issue:12

    Topics: Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Stability; Emulsions; Hemolysis; Humans; Hypn

2005
Effect of propofol and thiopentone on free radical mediated oxidative stress of the erythrocyte.
    British journal of anaesthesia, 1996, Volume: 76, Issue:4

    Topics: Adult; Anesthetics, Intravenous; Cell Culture Techniques; Erythrocytes; Female; Free Radical Scaveng

1996
Neurone-specific enolase and Sangtec 100 assays during cardiac surgery: Part I--The effects of heparin, protamine and propofol.
    Perfusion, 1997, Volume: 12, Issue:3

    Topics: Anesthetics, Intravenous; Anticoagulants; Blood Coagulation; Cardiopulmonary Bypass; Cerebrovascular

1997
Inhibition of glucose transport and direct interactions with type 1 facilitative glucose transporter (GLUT-1) by etomidate, ketamine, and propofol: a comparison with barbiturates.
    Biochemical pharmacology, 2000, Sep-01, Volume: 60, Issue:5

    Topics: 3T3 Cells; Anesthetics; Animals; Biological Transport; Cell Membrane; Cells, Cultured; Erythrocytes;

2000
Hemoglobin Zurich and cardiopulmonary bypass.
    Journal of cardiothoracic and vascular anesthesia, 2000, Volume: 14, Issue:6

    Topics: Anesthesia; Anesthetics, Intravenous; Antioxidants; Cardiopulmonary Bypass; Female; Heart Valve Pros

2000