propofol has been researched along with Heart Failure in 33 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Compared to earlier case reports in the literature, recently published cases describe older patients developing PRIS at lower doses of propofol, in whom arrhythmia, hypertriglyceridaemia and fever are less frequently seen, with survival more likely." | 8.91 | Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports. ( Anděl, M; Duška, F; Krajčová, A; Waldauf, P, 2015) |
| " Keywords were propofol, propofol infusion syndrome (PRIS), rhabdomyolysis, heart failure, arrhythmias, metabolic acidosis, brain injury, sedation, intensive care." | 8.86 | [Propofol infusion syndrome]. ( Greff, B; Laquay, N; Meyer, P; Orliaguet, G; Prieur, S, 2010) |
| "Propofol infusion syndrome is a rare but often fatal syndrome, characterized by lactacidosis, lipaemic plasma and cardiac failure, associated with propofol infusion over prolonged periods of time." | 8.83 | Propofol infusion syndrome in anaesthesia and intensive care medicine. ( Bein, B; Fudickar, A; Tonner, PH, 2006) |
| "Propofol infusion syndrome (PIS) is defined by arrhythmia, rhabdomyolysis, lactic acidosis, and unrecognized leads to death." | 7.80 | Propofol infusion syndrome: a lethal condition in critically injured patients eliminated by a simple screening protocol. ( Clement, LP; Croce, MA; Fabian, TC; Fischer, PE; Lee, M; Magnotti, LJ; Schroeppel, TJ; Sharpe, JP, 2014) |
| " Future controlled studies focusing on evaluating whether propofol manifests the derangements of critical illness more frequently than other sedatives will need to be large." | 7.75 | Incidence of propofol-related infusion syndrome in critically ill adults: a prospective, multicenter study. ( Anger, KE; Arpino, PA; Barletta, JF; Devlin, JW; Fong, JJ; Gerlach, AT; Grgurich, P; Kendall, E; Kuper, PJ; Papadopoulos, S; Roberts, RJ; Ruthazer, R; Schumaker, G; Szumita, PM; Voils, SA; Xamplas, R; Yogaratnam, D, 2009) |
| "Chronic congestive heart failure (CHF) was induced in rabbits with doxorubicin in order to evaluate: (1) haemodynamic and regional blood flow responses to propofol anaesthesia; (2) modification of these cardiovascular responses with background intravenous infusions of enalaprilat or dopexamine." | 7.69 | Regional blood flow effects of dopexamine versus enalaprilat during propofol anaesthesia in rabbits with experimental chronic heart failure. ( Blake, DW; McGrath, BP; Trigg, L; Way, D, 1994) |
| "Propofol has gained popularity for its rapid onset and rapid recovery even after prolonged use, and for the neuroprotection conferred." | 6.44 | Propofol infusion syndrome: an overview of a perplexing disease. ( Fodale, V; La Monaca, E, 2008) |
| "Propofol is a potent and widely used central-acting sedative drug." | 5.35 | Propofol infusion syndrome with arrhythmia, myocardial fat accumulation and cardiac failure. ( Jorens, PG; Van den Eynden, GG, 2009) |
| "Propofol has a direct and negative effect on basal myocyte contractile processes in the setting of CHF, which is more pronounced than that on healthy myocytes at reduced propofol concentrations." | 5.30 | Negative and selective effects of propofol on isolated swine myocyte contractile function in pacing-induced congestive heart failure. ( Clair, MJ; Dorman, BH; Hebbar, L; Roy, RC; Spinale, FG, 1997) |
| "Five children with upper respiratory tract infections aged between 4 weeks and 6 years." | 5.28 | Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports. ( Bray, RJ; Greenaway, CL; Parke, TJ; Rice, AS; Smith, PJ; Stevens, JE; Verghese, C; Waldmann, CS, 1992) |
| " Compared to earlier case reports in the literature, recently published cases describe older patients developing PRIS at lower doses of propofol, in whom arrhythmia, hypertriglyceridaemia and fever are less frequently seen, with survival more likely." | 4.91 | Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports. ( Anděl, M; Duška, F; Krajčová, A; Waldauf, P, 2015) |
| " Keywords were propofol, propofol infusion syndrome (PRIS), rhabdomyolysis, heart failure, arrhythmias, metabolic acidosis, brain injury, sedation, intensive care." | 4.86 | [Propofol infusion syndrome]. ( Greff, B; Laquay, N; Meyer, P; Orliaguet, G; Prieur, S, 2010) |
| "Propofol infusion syndrome is a rare but often fatal syndrome, characterized by lactacidosis, lipaemic plasma and cardiac failure, associated with propofol infusion over prolonged periods of time." | 4.83 | Propofol infusion syndrome in anaesthesia and intensive care medicine. ( Bein, B; Fudickar, A; Tonner, PH, 2006) |
| " This case report presents an 82-year-old female hemodialysis patient with chronic heart failure who underwent partial glossectomy for squamous cell carcinoma of the tongue under general anesthesia with remimazolam and remifentanil." | 4.31 | Anesthetic Management Using Remimazolam in a Hemodialysis Patient. ( Fujimoto, M; Hamaoka, M; Higuchi, H; Miyake, K; Miyake, S; Miyawaki, T; Nishioka, Y, 2023) |
| "Propofol infusion syndrome (PIS) is defined by arrhythmia, rhabdomyolysis, lactic acidosis, and unrecognized leads to death." | 3.80 | Propofol infusion syndrome: a lethal condition in critically injured patients eliminated by a simple screening protocol. ( Clement, LP; Croce, MA; Fabian, TC; Fischer, PE; Lee, M; Magnotti, LJ; Schroeppel, TJ; Sharpe, JP, 2014) |
| " Future controlled studies focusing on evaluating whether propofol manifests the derangements of critical illness more frequently than other sedatives will need to be large." | 3.75 | Incidence of propofol-related infusion syndrome in critically ill adults: a prospective, multicenter study. ( Anger, KE; Arpino, PA; Barletta, JF; Devlin, JW; Fong, JJ; Gerlach, AT; Grgurich, P; Kendall, E; Kuper, PJ; Papadopoulos, S; Roberts, RJ; Ruthazer, R; Schumaker, G; Szumita, PM; Voils, SA; Xamplas, R; Yogaratnam, D, 2009) |
| "Chronic congestive heart failure (CHF) was induced in rabbits with doxorubicin in order to evaluate: (1) haemodynamic and regional blood flow responses to propofol anaesthesia; (2) modification of these cardiovascular responses with background intravenous infusions of enalaprilat or dopexamine." | 3.69 | Regional blood flow effects of dopexamine versus enalaprilat during propofol anaesthesia in rabbits with experimental chronic heart failure. ( Blake, DW; McGrath, BP; Trigg, L; Way, D, 1994) |
| "Propofol is a potent intravenous anesthetic agent that rapidly induces sedation and unconsciousness." | 2.47 | Clinical effects and lethal and forensic aspects of propofol. ( Levy, RJ, 2011) |
| "Propofol has gained popularity for its rapid onset and rapid recovery even after prolonged use, and for the neuroprotection conferred." | 2.44 | Propofol infusion syndrome: an overview of a perplexing disease. ( Fodale, V; La Monaca, E, 2008) |
| "Propofol is a potent and widely used central-acting sedative drug." | 1.35 | Propofol infusion syndrome with arrhythmia, myocardial fat accumulation and cardiac failure. ( Jorens, PG; Van den Eynden, GG, 2009) |
| "The patient developed cardiac arrhythmia, metabolic acidosis, and cardiac failure, which resulted in death." | 1.31 | Death related to propofol use in an adult patient. ( Baerga-Varela, Y; Murray, MJ; Perrier, ND, 2000) |
| "Propofol was used as target-controlled infusion (plasma target concentration, 1." | 1.31 | Considerations in patients undergoing implantation of a biventricular pacemaker. ( Boldt, J; Lang, J; Lehmann, A; Thaler, E; Weisse, U; Zeitler, C, 2002) |
| "Propofol has a direct and negative effect on basal myocyte contractile processes in the setting of CHF, which is more pronounced than that on healthy myocytes at reduced propofol concentrations." | 1.30 | Negative and selective effects of propofol on isolated swine myocyte contractile function in pacing-induced congestive heart failure. ( Clair, MJ; Dorman, BH; Hebbar, L; Roy, RC; Spinale, FG, 1997) |
| "Five children with upper respiratory tract infections aged between 4 weeks and 6 years." | 1.28 | Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports. ( Bray, RJ; Greenaway, CL; Parke, TJ; Rice, AS; Smith, PJ; Stevens, JE; Verghese, C; Waldmann, CS, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (12.12) | 18.2507 |
| 2000's | 19 (57.58) | 29.6817 |
| 2010's | 7 (21.21) | 24.3611 |
| 2020's | 3 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Guerrero-Orriach, JL | 1 |
| Carmona-Luque, MD | 1 |
| Gonzalez-Alvarez, L | 1 |
| Nishioka, Y | 1 |
| Miyake, S | 1 |
| Hamaoka, M | 1 |
| Miyake, K | 1 |
| Fujimoto, M | 1 |
| Higuchi, H | 1 |
| Miyawaki, T | 1 |
| Schurr, JW | 1 |
| Sigal, I | 1 |
| Usman, A | 1 |
| Patel, P | 1 |
| Lefebvre, B | 1 |
| Kurcik, K | 1 |
| Atluri, P | 1 |
| Acker, M | 1 |
| Bermudez, C | 1 |
| Rame, JE | 1 |
| Hanff, T | 1 |
| Cevasco, M | 1 |
| Wald, J | 1 |
| Meng, T | 1 |
| Ren, X | 1 |
| Chen, X | 1 |
| Yu, J | 1 |
| Agrimi, J | 1 |
| Paolocci, N | 1 |
| Gao, WD | 1 |
| Schroeppel, TJ | 1 |
| Fabian, TC | 1 |
| Clement, LP | 1 |
| Fischer, PE | 1 |
| Magnotti, LJ | 1 |
| Sharpe, JP | 1 |
| Lee, M | 1 |
| Croce, MA | 1 |
| Krajčová, A | 1 |
| Waldauf, P | 1 |
| Anděl, M | 1 |
| Duška, F | 1 |
| Morillas-Sendín, P | 1 |
| Delgado-Baeza, E | 1 |
| Delgado-Martos, MJ | 1 |
| Barranco, M | 1 |
| del Cañizo, JF | 1 |
| Ruíz, M | 1 |
| Quintana-Villamandos, B | 1 |
| Jorens, PG | 1 |
| Van den Eynden, GG | 1 |
| Roberts, RJ | 1 |
| Barletta, JF | 1 |
| Fong, JJ | 1 |
| Schumaker, G | 1 |
| Kuper, PJ | 1 |
| Papadopoulos, S | 1 |
| Yogaratnam, D | 1 |
| Kendall, E | 1 |
| Xamplas, R | 1 |
| Gerlach, AT | 1 |
| Szumita, PM | 1 |
| Anger, KE | 1 |
| Arpino, PA | 1 |
| Voils, SA | 1 |
| Grgurich, P | 1 |
| Ruthazer, R | 1 |
| Devlin, JW | 1 |
| Laquay, N | 1 |
| Prieur, S | 1 |
| Greff, B | 1 |
| Meyer, P | 1 |
| Orliaguet, G | 1 |
| Levy, RJ | 1 |
| Annecke, T | 1 |
| Conzen, P | 1 |
| Ney, L | 1 |
| Bopp, C | 1 |
| Plachky, J | 1 |
| Hofer, S | 1 |
| Graf, BM | 1 |
| Weigand, MA | 1 |
| Fudickar, A | 1 |
| Bein, B | 1 |
| Tonner, PH | 1 |
| De Waele, JJ | 1 |
| Hoste, E | 1 |
| Lynch, G | 1 |
| Clinton, S | 1 |
| Siotia, A | 1 |
| Fodale, V | 1 |
| La Monaca, E | 1 |
| Bray, RJ | 3 |
| Blake, DW | 1 |
| Way, D | 1 |
| Trigg, L | 1 |
| McGrath, BP | 1 |
| Hebbar, L | 1 |
| Dorman, BH | 1 |
| Clair, MJ | 1 |
| Roy, RC | 1 |
| Spinale, FG | 1 |
| Rao, RR | 1 |
| Bequette, BW | 1 |
| Roy, RJ | 1 |
| Perrier, ND | 1 |
| Baerga-Varela, Y | 1 |
| Murray, MJ | 1 |
| Tanaka, Y | 1 |
| Negoro, T | 1 |
| Kubota, T | 1 |
| Hirota, K | 1 |
| Yoshida, H | 1 |
| Yatsu, Y | 1 |
| Maeda, A | 1 |
| Matsuki, A | 1 |
| Cremer, OL | 1 |
| Moons, KG | 1 |
| Bouman, EA | 1 |
| Kruijswijk, JE | 1 |
| de Smet, AM | 1 |
| Kalkman, CJ | 1 |
| Pittarello, D | 1 |
| Bonato, R | 1 |
| Armellin, G | 1 |
| Sorbara, C | 1 |
| Menon, DK | 1 |
| Matta, BF | 1 |
| Gupta, AK | 1 |
| Swami, A | 1 |
| Sprung, J | 1 |
| Ogletree-Hughes, ML | 1 |
| McConnell, BK | 1 |
| Zakhary, DR | 1 |
| Smolsky, SM | 1 |
| Moravec, CS | 1 |
| Lehmann, A | 1 |
| Lang, J | 1 |
| Thaler, E | 1 |
| Zeitler, C | 1 |
| Weisse, U | 1 |
| Boldt, J | 1 |
| Abrahams, JM | 1 |
| Reiter, GT | 1 |
| Acker, MA | 1 |
| Sinson, GP | 1 |
| Friedman, JA | 1 |
| Manno, E | 1 |
| Fulgham, JR | 1 |
| Parke, TJ | 1 |
| Stevens, JE | 1 |
| Rice, AS | 1 |
| Greenaway, CL | 1 |
| Smith, PJ | 1 |
| Waldmann, CS | 1 |
| Verghese, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Observer Rating Scale of Facial Expression Can Predict Dreaming in Propofol Anesthesia[NCT04235894] | 124 participants (Actual) | Observational | 2016-09-07 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for propofol and Heart Failure
| Article | Year |
|---|---|
Heart Failure after Cardiac Surgery: The Role of Halogenated Agents, Myocardial Conditioning and Oxidative Stress.
Topics: Anesthetics, Inhalation; Cardiac Surgical Procedures; Cardiomyopathies; Cardiotonic Agents; Heart Fa | 2022 |
Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports.
Topics: Anesthetics, Intravenous; Arrhythmias, Cardiac; Fever; Heart Failure; Hepatomegaly; Humans; Hypertri | 2015 |
[Propofol infusion syndrome].
Topics: Acidosis; Arrhythmias, Cardiac; Heart Failure; Humans; Hypnotics and Sedatives; Infusions, Intraveno | 2010 |
Clinical effects and lethal and forensic aspects of propofol.
Topics: Accidents; Acidosis; Acute Kidney Injury; Bacteremia; Bradycardia; Drug Overdose; Dyslipidemias; For | 2011 |
Propofol infusion syndrome in anaesthesia and intensive care medicine.
Topics: Acidosis; Anesthesia; Anesthetics, Intravenous; Critical Care; Heart Failure; Humans; Hyperlipidemia | 2006 |
Propofol infusion syndrome: an overview of a perplexing disease.
Topics: Acidosis; Anesthetics, Intravenous; Arrhythmias, Cardiac; Heart Failure; Hepatomegaly; Humans; Hypno | 2008 |
2 trials available for propofol and Heart Failure
| Article | Year |
|---|---|
Haemodynamic comparison of propofol-fentanyl anaesthesia with midazolam-fentanyl anaesthesia in CABG patients without preoperative heart failure.
Topics: Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Coronary Artery Bypass; Female; Fentanyl; H | 2000 |
[Alterations in left ventricular-arterial coupling and mechanical efficiency produced by remifentanil during cardiac anesthesia].
Topics: Aged; Anesthetics, Intravenous; Aorta; Cardiovascular Agents; Combined Modality Therapy; Coronary Ar | 2001 |
25 other studies available for propofol and Heart Failure
| Article | Year |
|---|---|
Anesthetic Management Using Remimazolam in a Hemodialysis Patient.
Topics: Aged, 80 and over; Anesthesia, General; Anesthetics, General; Benzodiazepines; Female; Heart Failure | 2023 |
Effect of Anesthesia Induction on Cardiac Hemodynamics in Patients Undergoing Durable Left Ventricular Assist Device Implantation: The EACH-LVAD Study.
Topics: Adult; Anesthesia; Heart Failure; Heart-Assist Devices; Hemodynamics; Humans; Propofol; Prospective | 2023 |
Anesthetic Agents Isoflurane and Propofol Decrease Maximal Ca
Topics: Anesthetics; Animals; Ca(2+) Mg(2+)-ATPase; Calcium; Female; Heart Failure; Isoflurane; Male; Myocar | 2019 |
Propofol infusion syndrome: a lethal condition in critically injured patients eliminated by a simple screening protocol.
Topics: Acidosis; Acute Kidney Injury; Adult; Anesthetics, Intravenous; Arrhythmias, Cardiac; Cohort Studies | 2014 |
Effects of Sevoflurane and Propofol on Organ Blood Flow in Left Ventricular Assist Devices in Pigs.
Topics: Animals; Heart Failure; Heart Ventricles; Heart-Assist Devices; Hemodynamics; Humans; Male; Methyl E | 2015 |
Propofol infusion syndrome with arrhythmia, myocardial fat accumulation and cardiac failure.
Topics: Arrhythmias, Cardiac; Brain Edema; Brain Injuries; Child; Diagnosis, Differential; Fatal Outcome; He | 2009 |
Incidence of propofol-related infusion syndrome in critically ill adults: a prospective, multicenter study.
Topics: Academic Medical Centers; Adult; Aged; Anesthetics, Intravenous; Arrhythmias, Cardiac; Critical Illn | 2009 |
Propofol-related infusion syndrome induced by "moderate dosage" in a patient with severe head trauma.
Topics: Acidosis; Adult; Anesthetics, Intravenous; Craniocerebral Trauma; Dose-Response Relationship, Drug; | 2012 |
[Anesthesia and intensive care medicine--status report. XIIIth International Symposium on Anesthesia in Heidelberg, March 19-21, 2004].
Topics: Anesthesia; Anesthesia, Conduction; Anesthesiology; Anesthetics, Intravenous; Blood Transfusion; Car | 2004 |
Propofol infusion syndrome in a patient with sepsis.
Topics: Abdominal Abscess; Acidosis; Adult; Anesthetics, Intravenous; Drainage; Heart Failure; Humans; Hyper | 2006 |
Anaesthesia and Alström's syndrome.
Topics: Adult; Anesthesia; Anesthetics, Intravenous; Atrial Fibrillation; Blindness; Deafness; Diabetes Mell | 2007 |
Fatal myocardial failure associated with a propofol infusion in a child.
Topics: Child; Fatal Outcome; Heart Failure; Humans; Influenza A virus; Influenza, Human; Infusions, Intrave | 1995 |
Regional blood flow effects of dopexamine versus enalaprilat during propofol anaesthesia in rabbits with experimental chronic heart failure.
Topics: Anesthesia; Animals; Blood Pressure; Cardiac Output; Dopamine; Doxorubicin; Enalaprilat; Heart Failu | 1994 |
Negative and selective effects of propofol on isolated swine myocyte contractile function in pacing-induced congestive heart failure.
Topics: Adrenergic beta-Agonists; Anesthetics, Intravenous; Animals; Cardiac Pacing, Artificial; Cardiotonic | 1997 |
Simultaneous regulation of hemodynamic and anesthetic states: a simulation study.
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Biomedical Engineering; Coronary Artery Bypass; Criti | 2000 |
Death related to propofol use in an adult patient.
Topics: Acidosis; Adolescent; Arrhythmias, Cardiac; Fatal Outcome; Heart Failure; Humans; Male; Propofol; Re | 2000 |
[Psoas compartment block for surgery of the femoral neck (trochanteric) fracture in a patient with severe heart failure due to rheumatoid myocarditis].
Topics: Aged; Anesthesia, Epidural; Conscious Sedation; Female; Femoral Neck Fractures; Heart Failure; Human | 2000 |
Long-term propofol infusion and cardiac failure in adult head-injured patients.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Brain Injuries; Heart Failure; Humans; Infusions, Intra | 2001 |
Propofol use in head-injury patients.
Topics: Adult; Brain Injuries; Cause of Death; Conscious Sedation; Dose-Response Relationship, Drug; Heart F | 2001 |
The effects of propofol on the contractility of failing and nonfailing human heart muscles.
Topics: Aged; Anesthetics, Intravenous; Calcium; Female; Heart; Heart Failure; Humans; In Vitro Techniques; | 2001 |
Considerations in patients undergoing implantation of a biventricular pacemaker.
Topics: Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Defibrillators, Implantable; Electrocardiog | 2002 |
Propofol infusion for ICU sedation in children.
Topics: Anesthetics, Intravenous; Child; Child, Preschool; Critical Care; Ethics, Medical; Heart Failure; Hu | 2002 |
Propofol.
Topics: Adolescent; Heart Failure; Humans; Infusions, Intravenous; Male; Propofol; Renal Insufficiency; Rhab | 2002 |
Propofol.
Topics: Adult; Heart Failure; Humans; Infusions, Intravenous; Male; Propofol; Renal Insufficiency; Rhabdomyo | 2002 |
Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports.
Topics: Acidosis; Acute Disease; Cause of Death; Child; Child, Preschool; Critical Care; Female; Heart Failu | 1992 |