propofol has been researched along with Heart Diseases in 23 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors present the hospital course of a 13-year-old girl with a closed head injury who received a prolonged infusion of propofol for sedation and, subsequently, died as a result of severe metabolic acidosis, rhabdomyolysis, and cardiovascular collapse." | 7.71 | Metabolic acidosis, rhabdomyolysis, and cardiovascular collapse after prolonged propofol infusion. ( Bauman, LA; Cannon, ML; Glazier, SS, 2001) |
| "During this period 44 children with respiratory tract infections had been admitted to this unit and sedated for at least 48 h." | 6.40 | Propofol infusion syndrome in children. ( Bray, RJ, 1998) |
| "The authors present the hospital course of a 13-year-old girl with a closed head injury who received a prolonged infusion of propofol for sedation and, subsequently, died as a result of severe metabolic acidosis, rhabdomyolysis, and cardiovascular collapse." | 3.71 | Metabolic acidosis, rhabdomyolysis, and cardiovascular collapse after prolonged propofol infusion. ( Bauman, LA; Cannon, ML; Glazier, SS, 2001) |
| "Among the 2576 cases in ESRD patients, 1374 were in the TIVA group and 1202 were in the volatile group." | 3.01 | The influence of propofol-based total intravenous anesthesia on postoperative outcomes in end-stage renal disease patients: A retrospective observation study. ( Cho, HB; Chung, JW; Jang, YS; Kim, MG; Kim, SH; Lee, HK; Park, S; Park, SY; Song, S; Yoo, JH, 2021) |
| "Propofol proves to be an excellent sedative for therapeutic ERCP." | 2.71 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography. ( Chen, WX; Gu, Q; Gu, ZY; Li, YM; Lin, HJ; Yu, CH; Zhang, WF; Zhong, XQ, 2005) |
| "All tachyarrhythmias that occurred in the atria and ventricles were analyzed." | 2.58 | Does dexmedetomidine have an antiarrhythmic effect on cardiac patients? A meta-analysis of randomized controlled trials. ( Ling, X; Ni, Y; Wu, C; Zhang, C; Zhou, H; Zhu, Z, 2018) |
| "During this period 44 children with respiratory tract infections had been admitted to this unit and sedated for at least 48 h." | 2.40 | Propofol infusion syndrome in children. ( Bray, RJ, 1998) |
| "Propofol is an intravenous anaesthetic which is chemically unrelated to other iv anaesthetics." | 2.38 | Propofol in patients with cardiac disease. ( Sahab, P; Searle, NR, 1993) |
| "Propofol was the strongest depressant among the 3 compounds tested, exhibiting the largest decrease in contraction velocity, depression rate, and beating frequency." | 1.56 | An In Vitro Model for Identifying Cardiac Side Effects of Anesthetics. ( Bertaccini, EJ; Blau, HM; Chang, ACH; Chang, ACY; Davies, MF; Holbrook, C; Nicin, L; Weber, GJ, 2020) |
| "When propofol was used to maintain anaesthesia, either by repeat injections, or by infusion, with the patient breathing spontaneously and not undergoing painful stimuli, blood pressure and heart rate remained steady within 55 to 65% of their initial values." | 1.27 | [Hemodynamic effects of propofol]. ( du Grés, B, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Barends, CRM | 1 |
| Driesens, MK | 1 |
| van Amsterdam, K | 1 |
| Struys, MMRF | 1 |
| Absalom, AR | 1 |
| Cho, HB | 1 |
| Kim, MG | 1 |
| Park, SY | 1 |
| Song, S | 1 |
| Jang, YS | 1 |
| Park, S | 1 |
| Lee, HK | 1 |
| Yoo, JH | 1 |
| Chung, JW | 1 |
| Kim, SH | 1 |
| Ling, X | 1 |
| Zhou, H | 1 |
| Ni, Y | 1 |
| Wu, C | 1 |
| Zhang, C | 1 |
| Zhu, Z | 1 |
| Maestro Antolín, S | 1 |
| Moreira Da Silva, BA | 1 |
| Santos Santamarta, F | 1 |
| Germade, A | 1 |
| Pérez Citores, L | 1 |
| Santamaría, A | 1 |
| Bonoso Criado, R | 1 |
| Madrigal, RE | 1 |
| Saracibar, E | 1 |
| Barcenilla Laguna, J | 1 |
| Igea Arisqueta, F | 1 |
| Pérez-Millán, AG | 1 |
| Chang, ACY | 1 |
| Chang, ACH | 1 |
| Nicin, L | 1 |
| Weber, GJ | 1 |
| Holbrook, C | 1 |
| Davies, MF | 1 |
| Blau, HM | 1 |
| Bertaccini, EJ | 1 |
| Li, F | 1 |
| Yuan, Y | 1 |
| Diaz, LK | 1 |
| Jones, L | 1 |
| Boat, A | 1 |
| Mahmoud, M | 1 |
| Michelfelder, EC | 1 |
| Lin, E | 1 |
| Ngamprasertwong, P | 1 |
| Schnell, B | 1 |
| Kurth, CD | 1 |
| Crombleholme, TM | 1 |
| Sadhasivam, S | 1 |
| Maletov, SA | 1 |
| Ivanchenko, VI | 1 |
| Kornienko, AN | 1 |
| Kirtaev, AN | 1 |
| Bashlykova, TV | 1 |
| De Hert, SG | 1 |
| Van der Linden, PJ | 1 |
| Cromheecke, S | 1 |
| Meeus, R | 1 |
| Nelis, A | 1 |
| Van Reeth, V | 1 |
| ten Broecke, PW | 1 |
| De Blier, IG | 1 |
| Stockman, BA | 1 |
| Rodrigus, IE | 1 |
| Chen, WX | 1 |
| Lin, HJ | 1 |
| Zhang, WF | 1 |
| Gu, Q | 1 |
| Zhong, XQ | 1 |
| Yu, CH | 1 |
| Li, YM | 1 |
| Gu, ZY | 1 |
| Vetrugno, L | 1 |
| Cheli, G | 1 |
| Bassi, F | 1 |
| Giordano, F | 1 |
| Zimmer, C | 1 |
| Piepenbrink, K | 1 |
| Riest, G | 1 |
| Peters, J | 1 |
| Lucchinetti, E | 1 |
| Hofer, C | 1 |
| Bestmann, L | 1 |
| Hersberger, M | 1 |
| Feng, J | 1 |
| Zhu, M | 1 |
| Furrer, L | 1 |
| Schaub, MC | 1 |
| Tavakoli, R | 1 |
| Genoni, M | 1 |
| Zollinger, A | 1 |
| Zaugg, M | 1 |
| Rosenberg, PH | 1 |
| Hall, RI | 1 |
| Murphy, JT | 1 |
| Landymore, R | 1 |
| Pollak, PT | 1 |
| Doak, G | 1 |
| Murray, M | 1 |
| Searle, NR | 1 |
| Sahab, P | 1 |
| Hertel, VG | 1 |
| Olthoff, D | 1 |
| Vetter, B | 1 |
| Giessner, O | 1 |
| Lange, S | 1 |
| Kokita, N | 1 |
| Hara, A | 1 |
| Bray, RJ | 1 |
| Myburgh, JA | 1 |
| Upton, RN | 1 |
| Cannon, ML | 1 |
| Glazier, SS | 1 |
| Bauman, LA | 1 |
| du Grés, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison Between the Effect of Target-controlled Infusion of Propofol and Sevoflurane as Maintenance of Anesthesia to Intraoperative Hemodynamic Profile of Renal Transplant Recipient[NCT03214653] | 23 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| Midazolam With Meperidine and Dexmedetomidine vs Midazolam With Meperidine for Sedation During ERCP[NCT01404689] | Phase 4 | 110 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| Etomidate With Meperidine vs Midazolam With Meperidine for Sedation During Endodscopic Retrograde Cholangiopancreatogram (ERCP)[NCT02027311] | Phase 4 | 63 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| Optimierung Der Kardioprotektion Durch Inhalative Anästhetika Eine Untersuchung Bei Patienten Mit Diabetes Mellitus während Off-pump Herzchirurgie[NCT02407626] | 2 participants (Actual) | Interventional | 2015-09-30 | Terminated (stopped due to Very low patient recruitment, changed insurance requirements) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Hypoxia defined as peripheral blood oxygen saturation measured by pulse oxymeter < 90% (NCT02027311)
Timeframe: Every 5min in Preoperative, intraoperative phase and 15 min in Recovery phase
| Intervention | Hypoxia events (Number) |
|---|---|
| Midazolam | 19 |
| Etomidate | 27 |
The frequency of intervention which was defined as any restraint of the patient's head, arms, or legs if they became agitated, or if patient movement was not controlled with verbal instruction from the endoscopist during the whole intraoperative phases. (NCT02027311)
Timeframe: Throughout the whole ERCP procedure
| Intervention | Number of intervention (Mean) |
|---|---|
| Etomidate | 1.9 |
| Midazolam | 7.5 |
4 reviews available for propofol and Heart Diseases
| Article | Year |
|---|---|
Does dexmedetomidine have an antiarrhythmic effect on cardiac patients? A meta-analysis of randomized controlled trials.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Coronary Artery Bypass; Databases | 2018 |
Meta-analysis of the cardioprotective effect of sevoflurane versus propofol during cardiac surgery.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Atrial Fibrillation; Cardiac Output; Cardiac Surg | 2015 |
Propofol in patients with cardiac disease.
Topics: Anesthesia, Intravenous; Conscious Sedation; Heart Diseases; Humans; Intensive Care Units; Postopera | 1993 |
Propofol infusion syndrome in children.
Topics: Acidosis; Child; Child, Preschool; Female; Heart Diseases; Humans; Hypnotics and Sedatives; Infant; | 1998 |
5 trials available for propofol and Heart Diseases
| Article | Year |
|---|---|
The influence of propofol-based total intravenous anesthesia on postoperative outcomes in end-stage renal disease patients: A retrospective observation study.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Intravenous; Female; Heart Diseases; Humans; Incidence; | 2021 |
Cardioprotective properties of sevoflurane in patients undergoing coronary surgery with cardiopulmonary bypass are related to the modalities of its administration.
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave | 2004 |
Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography.
Topics: Adult; Aged; Amnesia; Blood Pressure; Case-Control Studies; Cholangiopancreatography, Endoscopic Ret | 2005 |
Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography.
Topics: Adult; Aged; Amnesia; Blood Pressure; Case-Control Studies; Cholangiopancreatography, Endoscopic Ret | 2005 |
Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography.
Topics: Adult; Aged; Amnesia; Blood Pressure; Case-Control Studies; Cholangiopancreatography, Endoscopic Ret | 2005 |
Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography.
Topics: Adult; Aged; Amnesia; Blood Pressure; Case-Control Studies; Cholangiopancreatography, Endoscopic Ret | 2005 |
Gene regulatory control of myocardial energy metabolism predicts postoperative cardiac function in patients undergoing off-pump coronary artery bypass graft surgery: inhalational versus intravenous anesthetics.
Topics: Aged; Aged, 80 and over; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarkers; Coronary Art | 2007 |
Myocardial metabolic and hemodynamic changes during propofol anesthesia for cardiac surgery in patients with reduced ventricular function.
Topics: Aged; Anesthesia, Intravenous; Female; Heart Diseases; Hemodynamics; Humans; Male; Middle Aged; Myoc | 1993 |
14 other studies available for propofol and Heart Diseases
| Article | Year |
|---|---|
Moderate-to-Deep Sedation Using Target-Controlled Infusions of Propofol and Remifentanil: Adverse Events and Risk Factors: A Retrospective Cohort Study of 2937 Procedures.
Topics: Aged; Body Mass Index; Cardiopulmonary Resuscitation; Cohort Studies; Critical Care; Deep Sedation; | 2020 |
Severe cardiorespiratory complications derived from propofol sedation monitored by an endoscopist.
Topics: Adult; Aged; Aged, 80 and over; Conscious Sedation; Endoscopy, Gastrointestinal; Female; Heart Disea | 2018 |
An In Vitro Model for Identifying Cardiac Side Effects of Anesthetics.
Topics: Adult; Anesthetics, Intravenous; Cardiotoxicity; Cell Line; Etomidate; Female; Heart Diseases; Heart | 2020 |
Sedating the child with congenital heart disease.
Topics: Adolescent; Analgesia; Barbiturates; Benzodiazepines; Child; Child, Preschool; Conscious Sedation; D | 2009 |
Supplementing desflurane with intravenous anesthesia reduces fetal cardiac dysfunction during open fetal surgery.
Topics: Adult; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intraveno | 2010 |
[Anesthesia during cardiosurgical operations based on high epidural blockade combined with pofol].
Topics: Aged; Anesthesia, Epidural; Anesthetics, Intravenous; Cardiac Surgical Procedures; Electrocardiograp | 2004 |
Cardiac anesthesia management of a patient with Bartter's syndrome.
Topics: Adjuvants, Anesthesia; Aged; Analgesics, Opioid; Anesthesia; Anesthetics, Intravenous; Angina, Unsta | 2005 |
[Cardiotoxic and neurotoxic effects after accidental intravascular bupivacaine administration. Therapy with lidocaine propofol and lipid emulsion].
Topics: Aged, 80 and over; Anesthesia, Epidural; Anesthetics, Intravenous; Anesthetics, Local; Blood Pressur | 2007 |
[Lipid emulsion for the treatment of severe local anesthetic toxicity in adults--probably useful, but evidence is lacking].
Topics: Adult; Advanced Cardiac Life Support; Anesthetics, Local; Cardiotonic Agents; Combined Modality Ther | 2008 |
[Comparison of various methods of anesthesia by plasma catecholamine determination].
Topics: Anesthesia, General; Arousal; Droperidol; Electroencephalography; Epinephrine; Extracorporeal Circul | 1995 |
Propofol attenuates hydrogen peroxide-induced mechanical and metabolic derangements in the isolated rat heart.
Topics: Animals; Antioxidants; Coronary Circulation; Energy Metabolism; Free Radical Scavengers; Heart; Hear | 1996 |
Propofol use in head-injury patients.
Topics: Acidosis; Adolescent; Adult; Anesthetics, Intravenous; Animals; Cardiac Output; Craniocerebral Traum | 2001 |
Metabolic acidosis, rhabdomyolysis, and cardiovascular collapse after prolonged propofol infusion.
Topics: Acidosis; Adolescent; Electrocardiography; Fatal Outcome; Female; Head Injuries, Closed; Heart Disea | 2001 |
[Hemodynamic effects of propofol].
Topics: Anesthesia, General; Anesthetics; Heart Diseases; Hemodynamics; Humans; Phenols; Propofol | 1987 |