Page last updated: 2024-11-03

propofol and Forearm Injuries

propofol has been researched along with Forearm Injuries in 2 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Forearm Injuries: Injuries to the part of the upper limb of the body between the wrist and elbow.

Research Excerpts

ExcerptRelevanceReference
"A case is presented of the use of a propofol infusion for anaesthesia in a patient with known variegate porphyria."7.67Is propofol a safe agent in porphyria? ( Hodkinson, BP; Weir, PM, 1988)
"A case is presented of the use of a propofol infusion for anaesthesia in a patient with known variegate porphyria."3.67Is propofol a safe agent in porphyria? ( Hodkinson, BP; Weir, PM, 1988)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sharieff, GQ1
Trocinski, DR1
Kanegaye, JT1
Fisher, B1
Harley, JR1
Weir, PM1
Hodkinson, BP1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison Between Efficacy of Ketamine and Propofol Mixture With 1:6 Ratio and 1:4 Ratio for Endoscopic Retrograde Procedure Sedation[NCT03196479]58 participants (Actual)Interventional2017-03-01Completed
Comparison of Ketamine Versus Co-Administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department[NCT01387139]Phase 3183 participants (Actual)Interventional2011-01-31Completed
Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial[NCT01269307]99 participants (Actual)Interventional2010-06-30Completed
A Randomized Double-blind Trial to Evaluate Ketamine-propofol Combination vs. Propofol Alone for Procedural Sedation and Analgesia in the Emergency Department.[NCT01211158]Phase 3284 participants (Actual)Interventional2010-12-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Efficacy of Sedation

"Efficacy is defined as:~The patient does not have unpleasant recall of the procedure.~The patient did not experience sedation-related adverse events resulting in abandonment of the procedure or a permanent complication or an unplanned admission to the hospital or prolonged emergency department (ED) observation~The patient did not actively resist or require physical restraint for completion of the procedure. The need for minimal redirection of movements should not be considered as active resistance or physical restraint.~The procedure was successful" (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour

Interventionparticipants (Number)
Ketamine Alone97
Ketamine Co-Administered With Propofol81

Nurse Satisfaction

Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour

Interventionunits on a scale (Median)
Ketamine Alone10
Ketamine Co-Administered With Propofol8

Parent Satisfaction

Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour

Interventionunits on a scale (1-10) (Median)
Ketamine Alone10
Ketamine Co-Administered With Propofol10

Physician Performing Procedure Satisfaction

Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour

Interventionunits on a scale (Median)
Ketamine Alone9
Ketamine Co-Administered With Propofol8

Recovery Time

Time until the patient has a Vancouver Sedation Recovery Scale Score of 18 or greater. (NCT01387139)
Timeframe: Once Vancouver Sedation Recovery Scale Score reaches 18 or greater, on average less than 1 hour

Interventionminutes (Median)
Ketamine Alone44
Ketamine Co-Administered With Propofol43.5

Frequency of Adverse Events

We will record all adverse events during the sedation, and then perform a follow-up call to determine if any additional adverse events occured after discharge. (NCT01387139)
Timeframe: From enrollment through completion of follow-up, up to 7 days

,
Interventionparticipants (Number)
Respiratory depressionCardiovascular eventvomiting/retchingUnpleasant recovery reaction
Ketamine Alone121214
Ketamine Co-Administered With Propofol150182

Other Studies

2 other studies available for propofol and Forearm Injuries

ArticleYear
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
    Pediatric emergency care, 2007, Volume: 23, Issue:12

    Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit

2007
Is propofol a safe agent in porphyria?
    Anaesthesia, 1988, Volume: 43, Issue:12

    Topics: Adult; Anesthesia, Intravenous; Anesthetics; Forearm Injuries; Humans; Liver Diseases; Male; Phenols

1988