Page last updated: 2024-11-03

propofol and Endotoxemia

propofol has been researched along with Endotoxemia in 23 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.

Research Excerpts

ExcerptRelevanceReference
"Experimental endotoxemia was induced by co-culture of Escherichia coli lipopolysaccharide (15 μg/mL) in the abovementioned three types of cells that were under the effect of propofol (15 or 30 μM for 1 or 4 hours)."7.78Differential influence of propofol on different cell types in terms of the expression of various oxidative stress-related enzymes in an experimental endotoxemia model. ( Chu, LM; Huang, CC; Liu, YC; Tsai, YC, 2012)
" Moreover, propofol anesthesia may protect against fatal cardiovascular depression during endotoxemia by attenuating the late stage NO surge in the aorta, possibly via inhibition of iNOS upregulation by the endotoxin."7.75Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia. ( Chan, JY; Chang, AY; Liu, YC; Tsai, YC, 2009)
" Compared with low dose (15 mg/kg/hr), high-dose (30 mg/kg/hr) propofol anesthesia profoundly suppressed the power density of BHF, BLF and BVLF of SAP signals during LPS-induced endotoxemia."7.75Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase. ( Chan, JY; Liu, YC; Tsai, YC, 2009)
"To clarify the effect of combined treatment with propofol and dexamethasone on hemodynamics, organ injury, and survival rate in rats with endotoxemia."7.74Combined effects of propofol and dexamethasone on rats with endotoxemia. ( Chen, A; Ho, ST; Liaw, WJ; Tsao, CM; Wu, CC, 2008)
"Endotoxemia decreases the dose requirement for anesthetics but no data are available for propofol."7.72The influence of endotoxemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat. ( Belpaire, FM; Boon, PA; Buylaert, WA; De Paepe, P; Van Hoey, G, 2003)
"To document the effects of propofol on the hemodynamic and inflammatory responses to endotoxemia in an animal model."7.70Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats. ( Kobayashi, T; Ohmoto, N; Ohta, K; Taniguchi, T; Yamamoto, K, 2000)
"Ketamine prevented the increase in markers of oxidative stress and inflammation mediators, both in plasma and lung tissue."5.39Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia-induced acute lung injury. ( Aricioglu, A; Cumaoglu, A; Ergin, V; Gokcinar, D; Menevse, A, 2013)
"Propofol treatment improved renal function in LPS-treated rats."5.37Protective effects of propofol on endotoxemia-induced acute kidney injury in rats. ( Bai, T; Cui, WY; Tian, AY, 2011)
"Propofol is an antiinflammatory and immunosuppressive drug."5.33Attenuation of acute lung injury with propofol in endotoxemia. ( Mikawa, K; Nishina, K; Obara, H; Takao, Y, 2005)
" We investigated the effect of propofol on HIF-1α expression and acute lung injury in LPS-treated mice."3.77Propofol inhibits lipopolysaccharide-induced lung epithelial cell injury by reducing hypoxia-inducible factor-1alpha expression. ( Cho, W; Chu, CC; Hsing, CH; Lin, MC; So, EC; Wang, JJ; Yeh, CH, 2011)
" Moreover, propofol anesthesia may protect against fatal cardiovascular depression during endotoxemia by attenuating the late stage NO surge in the aorta, possibly via inhibition of iNOS upregulation by the endotoxin."3.75Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia. ( Chan, JY; Chang, AY; Liu, YC; Tsai, YC, 2009)
" Compared with low dose (15 mg/kg/hr), high-dose (30 mg/kg/hr) propofol anesthesia profoundly suppressed the power density of BHF, BLF and BVLF of SAP signals during LPS-induced endotoxemia."3.75Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase. ( Chan, JY; Liu, YC; Tsai, YC, 2009)
"To document the effects of propofol on the hemodynamic and inflammatory responses to endotoxemia in an animal model."3.70Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats. ( Kobayashi, T; Ohmoto, N; Ohta, K; Taniguchi, T; Yamamoto, K, 2000)
"Ketamine prevented the increase in markers of oxidative stress and inflammation mediators, both in plasma and lung tissue."1.39Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia-induced acute lung injury. ( Aricioglu, A; Cumaoglu, A; Ergin, V; Gokcinar, D; Menevse, A, 2013)
"Propofol treatment improved renal function in LPS-treated rats."1.37Protective effects of propofol on endotoxemia-induced acute kidney injury in rats. ( Bai, T; Cui, WY; Tian, AY, 2011)
"Propofol is an antiinflammatory and immunosuppressive drug."1.33Attenuation of acute lung injury with propofol in endotoxemia. ( Mikawa, K; Nishina, K; Obara, H; Takao, Y, 2005)
"Human septic shock can be replicated in the endotoxaemic pig."1.31Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock. ( Basu, S; Eriksson, MB; Kiiski, R; Larsson, AO; Mutschler, DK; Nordgren, A, 2001)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (47.83)29.6817
2010's11 (47.83)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Chang, H1
Li, S1
Li, Y1
Hu, H1
Cheng, B1
Miao, J1
Gao, H1
Ma, H1
Gao, Y1
Wang, Q2
Gokcinar, D1
Ergin, V1
Cumaoglu, A1
Menevse, A1
Aricioglu, A1
Chen, SH1
Kung, CC1
Fung, ST1
Zorrilla-Vaca, A1
Tang, J2
Hu, JJ1
Lu, CH1
Liang, JN1
Xiao, JF1
Liu, YT1
Lin, CS1
Qin, ZS1
Yu, T1
Li, Q1
Liu, L1
Guo, F1
Longhini, F1
Yang, Y1
Qiu, H1
Liu, YC3
Chang, AY1
Tsai, YC3
Chan, JY2
Sun, Y1
Wu, WK1
Zhong, T1
Liu, Y1
Xiao, J1
Tao, T1
Zhao, Z1
Gu, M1
Yeh, CH1
Cho, W1
So, EC1
Chu, CC1
Lin, MC1
Wang, JJ1
Hsing, CH1
Cui, WY1
Tian, AY1
Bai, T1
Tsao, CM2
Chen, SJ1
Tsou, MY1
Wu, CC2
Li, Z1
Zhao, G1
Zhou, G1
Wang, Y1
Ji, J1
Wang, Z1
Huang, CC1
Chu, LM1
De Paepe, P1
Belpaire, FM1
Van Hoey, G1
Boon, PA1
Buylaert, WA1
Takemoto, Y1
Takao, Y1
Mikawa, K1
Nishina, K1
Obara, H1
Zhang, H1
Xue, ZG1
Jiang, H1
Ho, ST1
Liaw, WJ1
Chen, A1
Taniguchi, T1
Yamamoto, K1
Ohmoto, N1
Ohta, K1
Kobayashi, T1
Ault, ML1
Zaloga, GP1
Marik, PE1
Basu, S1
Mutschler, DK1
Larsson, AO1
Kiiski, R1
Nordgren, A1
Eriksson, MB1

Other Studies

23 other studies available for propofol and Endotoxemia

ArticleYear
Effect of sedation with dexmedetomidine or propofol on gastrointestinal motility in lipopolysaccharide-induced endotoxemic mice.
    BMC anesthesiology, 2020, 09-07, Volume: 20, Issue:1

    Topics: Animals; Dexmedetomidine; Dose-Response Relationship, Drug; Endotoxemia; Gastric Emptying; Gastroint

2020
Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia-induced acute lung injury.
    Acta biochimica Polonica, 2013, Volume: 60, Issue:3

    Topics: Acute Lung Injury; Administration, Intravenous; Animals; Anti-Inflammatory Agents; Antioxidants; Bio

2013
Endotoxemia due to propofol contamination in four consecutive patients.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2014, Volume: 113, Issue:5

    Topics: Drug Contamination; Endotoxemia; Humans; Propofol

2014
Risk of endotoxemia associated with clinical incidence of contaminated propofol.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2014, Volume: 113, Issue:7

    Topics: Drug Contamination; Endotoxemia; Humans; Propofol

2014
Propofol inhibits lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depression through decreasing the generation of superoxide anion in cardiomyocytes.
    Oxidative medicine and cellular longevity, 2014, Volume: 2014

    Topics: Anesthetics, Intravenous; Animals; Cell Survival; Cells, Cultured; Depression; Endotoxemia; Heart; L

2014
Different effects of propofol and dexmedetomidine on preload dependency in endotoxemic shock with norepinephrine infusion.
    The Journal of surgical research, 2015, Volume: 198, Issue:1

    Topics: Animals; Blood Pressure; Cardiac Output; Dexmedetomidine; Endotoxemia; Heart Rate; Norepinephrine; P

2015
Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia.
    Journal of biomedical science, 2009, Jan-15, Volume: 16

    Topics: Anesthetics, Intravenous; Animals; Cardiovascular System; Endotoxemia; Humans; Isoenzymes; Lipid Per

2009
Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase.
    Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2009, Volume: 47, Issue:2

    Topics: Anesthetics, Intravenous; Animals; Blood Pressure; Dose-Response Relationship, Drug; Endotoxemia; Is

2009
Propofol lowers serum PF4 level and partially corrects hypercoagulopathy in endotoxemic rats.
    Biochimica et biophysica acta, 2010, Volume: 1804, Issue:9

    Topics: Animals; Antithrombin III; Blood Coagulation; Blood Coagulation Tests; Blood Proteins; Blotting, Wes

2010
Propofol inhibits lipopolysaccharide-induced lung epithelial cell injury by reducing hypoxia-inducible factor-1alpha expression.
    British journal of anaesthesia, 2011, Volume: 106, Issue:4

    Topics: Acute Lung Injury; Anesthetics, Intravenous; Animals; Apoptosis; Cells, Cultured; Cytokines; Disease

2011
Protective effects of propofol on endotoxemia-induced acute kidney injury in rats.
    Clinical and experimental pharmacology & physiology, 2011, Volume: 38, Issue:11

    Topics: Acute Kidney Injury; Animals; Apoptosis; Aquaporins; bcl-2-Associated X Protein; Blood Urea Nitrogen

2011
Effect of propofol on vascular reactivity in thoracic aortas from rats with endotoxemia.
    Journal of the Chinese Medical Association : JCMA, 2012, Volume: 75, Issue:6

    Topics: Animals; Aorta, Thoracic; Calcium; Dose-Response Relationship, Drug; Endotoxemia; Lipopolysaccharide

2012
Inhibition of S100A9 expression by propofol in monocytes of rats with endotoxemia.
    Molecular medicine reports, 2012, Volume: 6, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Calgranulin B; Down-Regulation; Electrophoresis, Gel, Two-Dimensi

2012
Differential influence of propofol on different cell types in terms of the expression of various oxidative stress-related enzymes in an experimental endotoxemia model.
    Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 2012, Volume: 50, Issue:4

    Topics: Animals; Endotoxemia; Lung; Macrophages; Male; Myocytes, Cardiac; NADPH Oxidases; Nitric Oxide Synth

2012
The influence of endotoxemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat.
    Journal of pharmaceutical sciences, 2003, Volume: 92, Issue:1

    Topics: Animals; Electroencephalography; Endotoxemia; Endotoxins; Male; Propofol; Rats; Rats, Wistar

2003
Dose effects of propofol on hemodynamic and cytokine responses to endotoxemia in rats.
    Journal of anesthesia, 2005, Volume: 19, Issue:1

    Topics: Anesthetics, Intravenous; Animals; Blood Gas Analysis; Cytokines; Dose-Response Relationship, Drug;

2005
Attenuation of acute lung injury with propofol in endotoxemia.
    Anesthesia and analgesia, 2005, Volume: 100, Issue:3

    Topics: Animals; Blood Pressure; Endotoxemia; Lung; Male; Nitric Oxide Synthase; Peroxynitrous Acid; Propofo

2005
[The effect of posttreatment with isoflurane versus propofol on pulmonary alveolar capillary barrier in endotoxemic rats].
    Zhonghua yi xue za zhi, 2005, Jun-29, Volume: 85, Issue:24

    Topics: Animals; Blood-Air Barrier; Capillaries; Capillary Permeability; Endotoxemia; Isoflurane; Lipopolysa

2005
Combined effects of propofol and dexamethasone on rats with endotoxemia.
    Critical care medicine, 2008, Volume: 36, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; Drug Therapy, Combination; Endotoxemia; Male; Prop

2008
Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats.
    Critical care medicine, 2000, Volume: 28, Issue:4

    Topics: Animals; Drug Evaluation, Preclinical; Endotoxemia; Escherichia coli Infections; Hemodynamics; Hypno

2000
Goldilocks and the three cytokines.
    Critical care medicine, 2000, Volume: 28, Issue:4

    Topics: Animals; Cytokines; Drug Evaluation, Preclinical; Endotoxemia; Humans; Hypnotics and Sedatives; Immu

2000
Not all propofol is created equal.
    Critical care medicine, 2001, Volume: 29, Issue:2

    Topics: Animals; Chemistry, Pharmaceutical; Drug Carriers; Endotoxemia; Free Radical Scavengers; Humans; Hyp

2001
Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock.
    Resuscitation, 2001, Volume: 50, Issue:3

    Topics: Anesthetics, Intravenous; Animals; Dinoprost; Endotoxemia; Escherichia coli Infections; F2-Isoprosta

2001