propofol has been researched along with Endotoxemia in 23 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experimental endotoxemia was induced by co-culture of Escherichia coli lipopolysaccharide (15 μg/mL) in the abovementioned three types of cells that were under the effect of propofol (15 or 30 μM for 1 or 4 hours)." | 7.78 | Differential influence of propofol on different cell types in terms of the expression of various oxidative stress-related enzymes in an experimental endotoxemia model. ( Chu, LM; Huang, CC; Liu, YC; Tsai, YC, 2012) |
| " Moreover, propofol anesthesia may protect against fatal cardiovascular depression during endotoxemia by attenuating the late stage NO surge in the aorta, possibly via inhibition of iNOS upregulation by the endotoxin." | 7.75 | Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia. ( Chan, JY; Chang, AY; Liu, YC; Tsai, YC, 2009) |
| " Compared with low dose (15 mg/kg/hr), high-dose (30 mg/kg/hr) propofol anesthesia profoundly suppressed the power density of BHF, BLF and BVLF of SAP signals during LPS-induced endotoxemia." | 7.75 | Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase. ( Chan, JY; Liu, YC; Tsai, YC, 2009) |
| "To clarify the effect of combined treatment with propofol and dexamethasone on hemodynamics, organ injury, and survival rate in rats with endotoxemia." | 7.74 | Combined effects of propofol and dexamethasone on rats with endotoxemia. ( Chen, A; Ho, ST; Liaw, WJ; Tsao, CM; Wu, CC, 2008) |
| "Endotoxemia decreases the dose requirement for anesthetics but no data are available for propofol." | 7.72 | The influence of endotoxemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat. ( Belpaire, FM; Boon, PA; Buylaert, WA; De Paepe, P; Van Hoey, G, 2003) |
| "To document the effects of propofol on the hemodynamic and inflammatory responses to endotoxemia in an animal model." | 7.70 | Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats. ( Kobayashi, T; Ohmoto, N; Ohta, K; Taniguchi, T; Yamamoto, K, 2000) |
| "Ketamine prevented the increase in markers of oxidative stress and inflammation mediators, both in plasma and lung tissue." | 5.39 | Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia-induced acute lung injury. ( Aricioglu, A; Cumaoglu, A; Ergin, V; Gokcinar, D; Menevse, A, 2013) |
| "Propofol treatment improved renal function in LPS-treated rats." | 5.37 | Protective effects of propofol on endotoxemia-induced acute kidney injury in rats. ( Bai, T; Cui, WY; Tian, AY, 2011) |
| "Propofol is an antiinflammatory and immunosuppressive drug." | 5.33 | Attenuation of acute lung injury with propofol in endotoxemia. ( Mikawa, K; Nishina, K; Obara, H; Takao, Y, 2005) |
| " We investigated the effect of propofol on HIF-1α expression and acute lung injury in LPS-treated mice." | 3.77 | Propofol inhibits lipopolysaccharide-induced lung epithelial cell injury by reducing hypoxia-inducible factor-1alpha expression. ( Cho, W; Chu, CC; Hsing, CH; Lin, MC; So, EC; Wang, JJ; Yeh, CH, 2011) |
| " Moreover, propofol anesthesia may protect against fatal cardiovascular depression during endotoxemia by attenuating the late stage NO surge in the aorta, possibly via inhibition of iNOS upregulation by the endotoxin." | 3.75 | Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia. ( Chan, JY; Chang, AY; Liu, YC; Tsai, YC, 2009) |
| " Compared with low dose (15 mg/kg/hr), high-dose (30 mg/kg/hr) propofol anesthesia profoundly suppressed the power density of BHF, BLF and BVLF of SAP signals during LPS-induced endotoxemia." | 3.75 | Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase. ( Chan, JY; Liu, YC; Tsai, YC, 2009) |
| "To document the effects of propofol on the hemodynamic and inflammatory responses to endotoxemia in an animal model." | 3.70 | Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats. ( Kobayashi, T; Ohmoto, N; Ohta, K; Taniguchi, T; Yamamoto, K, 2000) |
| "Ketamine prevented the increase in markers of oxidative stress and inflammation mediators, both in plasma and lung tissue." | 1.39 | Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia-induced acute lung injury. ( Aricioglu, A; Cumaoglu, A; Ergin, V; Gokcinar, D; Menevse, A, 2013) |
| "Propofol treatment improved renal function in LPS-treated rats." | 1.37 | Protective effects of propofol on endotoxemia-induced acute kidney injury in rats. ( Bai, T; Cui, WY; Tian, AY, 2011) |
| "Propofol is an antiinflammatory and immunosuppressive drug." | 1.33 | Attenuation of acute lung injury with propofol in endotoxemia. ( Mikawa, K; Nishina, K; Obara, H; Takao, Y, 2005) |
| "Human septic shock can be replicated in the endotoxaemic pig." | 1.31 | Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock. ( Basu, S; Eriksson, MB; Kiiski, R; Larsson, AO; Mutschler, DK; Nordgren, A, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (47.83) | 29.6817 |
| 2010's | 11 (47.83) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, H | 1 |
| Li, S | 1 |
| Li, Y | 1 |
| Hu, H | 1 |
| Cheng, B | 1 |
| Miao, J | 1 |
| Gao, H | 1 |
| Ma, H | 1 |
| Gao, Y | 1 |
| Wang, Q | 2 |
| Gokcinar, D | 1 |
| Ergin, V | 1 |
| Cumaoglu, A | 1 |
| Menevse, A | 1 |
| Aricioglu, A | 1 |
| Chen, SH | 1 |
| Kung, CC | 1 |
| Fung, ST | 1 |
| Zorrilla-Vaca, A | 1 |
| Tang, J | 2 |
| Hu, JJ | 1 |
| Lu, CH | 1 |
| Liang, JN | 1 |
| Xiao, JF | 1 |
| Liu, YT | 1 |
| Lin, CS | 1 |
| Qin, ZS | 1 |
| Yu, T | 1 |
| Li, Q | 1 |
| Liu, L | 1 |
| Guo, F | 1 |
| Longhini, F | 1 |
| Yang, Y | 1 |
| Qiu, H | 1 |
| Liu, YC | 3 |
| Chang, AY | 1 |
| Tsai, YC | 3 |
| Chan, JY | 2 |
| Sun, Y | 1 |
| Wu, WK | 1 |
| Zhong, T | 1 |
| Liu, Y | 1 |
| Xiao, J | 1 |
| Tao, T | 1 |
| Zhao, Z | 1 |
| Gu, M | 1 |
| Yeh, CH | 1 |
| Cho, W | 1 |
| So, EC | 1 |
| Chu, CC | 1 |
| Lin, MC | 1 |
| Wang, JJ | 1 |
| Hsing, CH | 1 |
| Cui, WY | 1 |
| Tian, AY | 1 |
| Bai, T | 1 |
| Tsao, CM | 2 |
| Chen, SJ | 1 |
| Tsou, MY | 1 |
| Wu, CC | 2 |
| Li, Z | 1 |
| Zhao, G | 1 |
| Zhou, G | 1 |
| Wang, Y | 1 |
| Ji, J | 1 |
| Wang, Z | 1 |
| Huang, CC | 1 |
| Chu, LM | 1 |
| De Paepe, P | 1 |
| Belpaire, FM | 1 |
| Van Hoey, G | 1 |
| Boon, PA | 1 |
| Buylaert, WA | 1 |
| Takemoto, Y | 1 |
| Takao, Y | 1 |
| Mikawa, K | 1 |
| Nishina, K | 1 |
| Obara, H | 1 |
| Zhang, H | 1 |
| Xue, ZG | 1 |
| Jiang, H | 1 |
| Ho, ST | 1 |
| Liaw, WJ | 1 |
| Chen, A | 1 |
| Taniguchi, T | 1 |
| Yamamoto, K | 1 |
| Ohmoto, N | 1 |
| Ohta, K | 1 |
| Kobayashi, T | 1 |
| Ault, ML | 1 |
| Zaloga, GP | 1 |
| Marik, PE | 1 |
| Basu, S | 1 |
| Mutschler, DK | 1 |
| Larsson, AO | 1 |
| Kiiski, R | 1 |
| Nordgren, A | 1 |
| Eriksson, MB | 1 |
23 other studies available for propofol and Endotoxemia
| Article | Year |
|---|---|
Effect of sedation with dexmedetomidine or propofol on gastrointestinal motility in lipopolysaccharide-induced endotoxemic mice.
Topics: Animals; Dexmedetomidine; Dose-Response Relationship, Drug; Endotoxemia; Gastric Emptying; Gastroint | 2020 |
Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia-induced acute lung injury.
Topics: Acute Lung Injury; Administration, Intravenous; Animals; Anti-Inflammatory Agents; Antioxidants; Bio | 2013 |
Endotoxemia due to propofol contamination in four consecutive patients.
Topics: Drug Contamination; Endotoxemia; Humans; Propofol | 2014 |
Risk of endotoxemia associated with clinical incidence of contaminated propofol.
Topics: Drug Contamination; Endotoxemia; Humans; Propofol | 2014 |
Propofol inhibits lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depression through decreasing the generation of superoxide anion in cardiomyocytes.
Topics: Anesthetics, Intravenous; Animals; Cell Survival; Cells, Cultured; Depression; Endotoxemia; Heart; L | 2014 |
Different effects of propofol and dexmedetomidine on preload dependency in endotoxemic shock with norepinephrine infusion.
Topics: Animals; Blood Pressure; Cardiac Output; Dexmedetomidine; Endotoxemia; Heart Rate; Norepinephrine; P | 2015 |
Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia.
Topics: Anesthetics, Intravenous; Animals; Cardiovascular System; Endotoxemia; Humans; Isoenzymes; Lipid Per | 2009 |
Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase.
Topics: Anesthetics, Intravenous; Animals; Blood Pressure; Dose-Response Relationship, Drug; Endotoxemia; Is | 2009 |
Propofol lowers serum PF4 level and partially corrects hypercoagulopathy in endotoxemic rats.
Topics: Animals; Antithrombin III; Blood Coagulation; Blood Coagulation Tests; Blood Proteins; Blotting, Wes | 2010 |
Propofol inhibits lipopolysaccharide-induced lung epithelial cell injury by reducing hypoxia-inducible factor-1alpha expression.
Topics: Acute Lung Injury; Anesthetics, Intravenous; Animals; Apoptosis; Cells, Cultured; Cytokines; Disease | 2011 |
Protective effects of propofol on endotoxemia-induced acute kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Apoptosis; Aquaporins; bcl-2-Associated X Protein; Blood Urea Nitrogen | 2011 |
Effect of propofol on vascular reactivity in thoracic aortas from rats with endotoxemia.
Topics: Animals; Aorta, Thoracic; Calcium; Dose-Response Relationship, Drug; Endotoxemia; Lipopolysaccharide | 2012 |
Inhibition of S100A9 expression by propofol in monocytes of rats with endotoxemia.
Topics: Animals; Anti-Inflammatory Agents; Calgranulin B; Down-Regulation; Electrophoresis, Gel, Two-Dimensi | 2012 |
Differential influence of propofol on different cell types in terms of the expression of various oxidative stress-related enzymes in an experimental endotoxemia model.
Topics: Animals; Endotoxemia; Lung; Macrophages; Male; Myocytes, Cardiac; NADPH Oxidases; Nitric Oxide Synth | 2012 |
The influence of endotoxemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat.
Topics: Animals; Electroencephalography; Endotoxemia; Endotoxins; Male; Propofol; Rats; Rats, Wistar | 2003 |
Dose effects of propofol on hemodynamic and cytokine responses to endotoxemia in rats.
Topics: Anesthetics, Intravenous; Animals; Blood Gas Analysis; Cytokines; Dose-Response Relationship, Drug; | 2005 |
Attenuation of acute lung injury with propofol in endotoxemia.
Topics: Animals; Blood Pressure; Endotoxemia; Lung; Male; Nitric Oxide Synthase; Peroxynitrous Acid; Propofo | 2005 |
[The effect of posttreatment with isoflurane versus propofol on pulmonary alveolar capillary barrier in endotoxemic rats].
Topics: Animals; Blood-Air Barrier; Capillaries; Capillary Permeability; Endotoxemia; Isoflurane; Lipopolysa | 2005 |
Combined effects of propofol and dexamethasone on rats with endotoxemia.
Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; Drug Therapy, Combination; Endotoxemia; Male; Prop | 2008 |
Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats.
Topics: Animals; Drug Evaluation, Preclinical; Endotoxemia; Escherichia coli Infections; Hemodynamics; Hypno | 2000 |
Goldilocks and the three cytokines.
Topics: Animals; Cytokines; Drug Evaluation, Preclinical; Endotoxemia; Humans; Hypnotics and Sedatives; Immu | 2000 |
Not all propofol is created equal.
Topics: Animals; Chemistry, Pharmaceutical; Drug Carriers; Endotoxemia; Free Radical Scavengers; Humans; Hyp | 2001 |
Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock.
Topics: Anesthetics, Intravenous; Animals; Dinoprost; Endotoxemia; Escherichia coli Infections; F2-Isoprosta | 2001 |