propofol has been researched along with Endotoxemia in 23 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
Excerpt | Relevance | Reference |
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"Experimental endotoxemia was induced by co-culture of Escherichia coli lipopolysaccharide (15 μg/mL) in the abovementioned three types of cells that were under the effect of propofol (15 or 30 μM for 1 or 4 hours)." | 7.78 | Differential influence of propofol on different cell types in terms of the expression of various oxidative stress-related enzymes in an experimental endotoxemia model. ( Chu, LM; Huang, CC; Liu, YC; Tsai, YC, 2012) |
" Moreover, propofol anesthesia may protect against fatal cardiovascular depression during endotoxemia by attenuating the late stage NO surge in the aorta, possibly via inhibition of iNOS upregulation by the endotoxin." | 7.75 | Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia. ( Chan, JY; Chang, AY; Liu, YC; Tsai, YC, 2009) |
" Compared with low dose (15 mg/kg/hr), high-dose (30 mg/kg/hr) propofol anesthesia profoundly suppressed the power density of BHF, BLF and BVLF of SAP signals during LPS-induced endotoxemia." | 7.75 | Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase. ( Chan, JY; Liu, YC; Tsai, YC, 2009) |
"To clarify the effect of combined treatment with propofol and dexamethasone on hemodynamics, organ injury, and survival rate in rats with endotoxemia." | 7.74 | Combined effects of propofol and dexamethasone on rats with endotoxemia. ( Chen, A; Ho, ST; Liaw, WJ; Tsao, CM; Wu, CC, 2008) |
"Endotoxemia decreases the dose requirement for anesthetics but no data are available for propofol." | 7.72 | The influence of endotoxemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat. ( Belpaire, FM; Boon, PA; Buylaert, WA; De Paepe, P; Van Hoey, G, 2003) |
"To document the effects of propofol on the hemodynamic and inflammatory responses to endotoxemia in an animal model." | 7.70 | Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats. ( Kobayashi, T; Ohmoto, N; Ohta, K; Taniguchi, T; Yamamoto, K, 2000) |
"Ketamine prevented the increase in markers of oxidative stress and inflammation mediators, both in plasma and lung tissue." | 5.39 | Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia-induced acute lung injury. ( Aricioglu, A; Cumaoglu, A; Ergin, V; Gokcinar, D; Menevse, A, 2013) |
"Propofol treatment improved renal function in LPS-treated rats." | 5.37 | Protective effects of propofol on endotoxemia-induced acute kidney injury in rats. ( Bai, T; Cui, WY; Tian, AY, 2011) |
"Propofol is an antiinflammatory and immunosuppressive drug." | 5.33 | Attenuation of acute lung injury with propofol in endotoxemia. ( Mikawa, K; Nishina, K; Obara, H; Takao, Y, 2005) |
" We investigated the effect of propofol on HIF-1α expression and acute lung injury in LPS-treated mice." | 3.77 | Propofol inhibits lipopolysaccharide-induced lung epithelial cell injury by reducing hypoxia-inducible factor-1alpha expression. ( Cho, W; Chu, CC; Hsing, CH; Lin, MC; So, EC; Wang, JJ; Yeh, CH, 2011) |
" Moreover, propofol anesthesia may protect against fatal cardiovascular depression during endotoxemia by attenuating the late stage NO surge in the aorta, possibly via inhibition of iNOS upregulation by the endotoxin." | 3.75 | Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia. ( Chan, JY; Chang, AY; Liu, YC; Tsai, YC, 2009) |
" Compared with low dose (15 mg/kg/hr), high-dose (30 mg/kg/hr) propofol anesthesia profoundly suppressed the power density of BHF, BLF and BVLF of SAP signals during LPS-induced endotoxemia." | 3.75 | Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase. ( Chan, JY; Liu, YC; Tsai, YC, 2009) |
"To document the effects of propofol on the hemodynamic and inflammatory responses to endotoxemia in an animal model." | 3.70 | Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats. ( Kobayashi, T; Ohmoto, N; Ohta, K; Taniguchi, T; Yamamoto, K, 2000) |
"Ketamine prevented the increase in markers of oxidative stress and inflammation mediators, both in plasma and lung tissue." | 1.39 | Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia-induced acute lung injury. ( Aricioglu, A; Cumaoglu, A; Ergin, V; Gokcinar, D; Menevse, A, 2013) |
"Propofol treatment improved renal function in LPS-treated rats." | 1.37 | Protective effects of propofol on endotoxemia-induced acute kidney injury in rats. ( Bai, T; Cui, WY; Tian, AY, 2011) |
"Propofol is an antiinflammatory and immunosuppressive drug." | 1.33 | Attenuation of acute lung injury with propofol in endotoxemia. ( Mikawa, K; Nishina, K; Obara, H; Takao, Y, 2005) |
"Human septic shock can be replicated in the endotoxaemic pig." | 1.31 | Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock. ( Basu, S; Eriksson, MB; Kiiski, R; Larsson, AO; Mutschler, DK; Nordgren, A, 2001) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 11 (47.83) | 29.6817 |
2010's | 11 (47.83) | 24.3611 |
2020's | 1 (4.35) | 2.80 |
Authors | Studies |
---|---|
Chang, H | 1 |
Li, S | 1 |
Li, Y | 1 |
Hu, H | 1 |
Cheng, B | 1 |
Miao, J | 1 |
Gao, H | 1 |
Ma, H | 1 |
Gao, Y | 1 |
Wang, Q | 2 |
Gokcinar, D | 1 |
Ergin, V | 1 |
Cumaoglu, A | 1 |
Menevse, A | 1 |
Aricioglu, A | 1 |
Chen, SH | 1 |
Kung, CC | 1 |
Fung, ST | 1 |
Zorrilla-Vaca, A | 1 |
Tang, J | 2 |
Hu, JJ | 1 |
Lu, CH | 1 |
Liang, JN | 1 |
Xiao, JF | 1 |
Liu, YT | 1 |
Lin, CS | 1 |
Qin, ZS | 1 |
Yu, T | 1 |
Li, Q | 1 |
Liu, L | 1 |
Guo, F | 1 |
Longhini, F | 1 |
Yang, Y | 1 |
Qiu, H | 1 |
Liu, YC | 3 |
Chang, AY | 1 |
Tsai, YC | 3 |
Chan, JY | 2 |
Sun, Y | 1 |
Wu, WK | 1 |
Zhong, T | 1 |
Liu, Y | 1 |
Xiao, J | 1 |
Tao, T | 1 |
Zhao, Z | 1 |
Gu, M | 1 |
Yeh, CH | 1 |
Cho, W | 1 |
So, EC | 1 |
Chu, CC | 1 |
Lin, MC | 1 |
Wang, JJ | 1 |
Hsing, CH | 1 |
Cui, WY | 1 |
Tian, AY | 1 |
Bai, T | 1 |
Tsao, CM | 2 |
Chen, SJ | 1 |
Tsou, MY | 1 |
Wu, CC | 2 |
Li, Z | 1 |
Zhao, G | 1 |
Zhou, G | 1 |
Wang, Y | 1 |
Ji, J | 1 |
Wang, Z | 1 |
Huang, CC | 1 |
Chu, LM | 1 |
De Paepe, P | 1 |
Belpaire, FM | 1 |
Van Hoey, G | 1 |
Boon, PA | 1 |
Buylaert, WA | 1 |
Takemoto, Y | 1 |
Takao, Y | 1 |
Mikawa, K | 1 |
Nishina, K | 1 |
Obara, H | 1 |
Zhang, H | 1 |
Xue, ZG | 1 |
Jiang, H | 1 |
Ho, ST | 1 |
Liaw, WJ | 1 |
Chen, A | 1 |
Taniguchi, T | 1 |
Yamamoto, K | 1 |
Ohmoto, N | 1 |
Ohta, K | 1 |
Kobayashi, T | 1 |
Ault, ML | 1 |
Zaloga, GP | 1 |
Marik, PE | 1 |
Basu, S | 1 |
Mutschler, DK | 1 |
Larsson, AO | 1 |
Kiiski, R | 1 |
Nordgren, A | 1 |
Eriksson, MB | 1 |
23 other studies available for propofol and Endotoxemia
Article | Year |
---|---|
Effect of sedation with dexmedetomidine or propofol on gastrointestinal motility in lipopolysaccharide-induced endotoxemic mice.
Topics: Animals; Dexmedetomidine; Dose-Response Relationship, Drug; Endotoxemia; Gastric Emptying; Gastroint | 2020 |
Effects of ketamine, propofol, and ketofol on proinflammatory cytokines and markers of oxidative stress in a rat model of endotoxemia-induced acute lung injury.
Topics: Acute Lung Injury; Administration, Intravenous; Animals; Anti-Inflammatory Agents; Antioxidants; Bio | 2013 |
Endotoxemia due to propofol contamination in four consecutive patients.
Topics: Drug Contamination; Endotoxemia; Humans; Propofol | 2014 |
Risk of endotoxemia associated with clinical incidence of contaminated propofol.
Topics: Drug Contamination; Endotoxemia; Humans; Propofol | 2014 |
Propofol inhibits lipopolysaccharide-induced tumor necrosis factor-alpha expression and myocardial depression through decreasing the generation of superoxide anion in cardiomyocytes.
Topics: Anesthetics, Intravenous; Animals; Cell Survival; Cells, Cultured; Depression; Endotoxemia; Heart; L | 2014 |
Different effects of propofol and dexmedetomidine on preload dependency in endotoxemic shock with norepinephrine infusion.
Topics: Animals; Blood Pressure; Cardiac Output; Dexmedetomidine; Endotoxemia; Heart Rate; Norepinephrine; P | 2015 |
Differential protection against oxidative stress and nitric oxide overproduction in cardiovascular and pulmonary systems by propofol during endotoxemia.
Topics: Anesthetics, Intravenous; Animals; Cardiovascular System; Endotoxemia; Humans; Isoenzymes; Lipid Per | 2009 |
Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase.
Topics: Anesthetics, Intravenous; Animals; Blood Pressure; Dose-Response Relationship, Drug; Endotoxemia; Is | 2009 |
Propofol lowers serum PF4 level and partially corrects hypercoagulopathy in endotoxemic rats.
Topics: Animals; Antithrombin III; Blood Coagulation; Blood Coagulation Tests; Blood Proteins; Blotting, Wes | 2010 |
Propofol inhibits lipopolysaccharide-induced lung epithelial cell injury by reducing hypoxia-inducible factor-1alpha expression.
Topics: Acute Lung Injury; Anesthetics, Intravenous; Animals; Apoptosis; Cells, Cultured; Cytokines; Disease | 2011 |
Protective effects of propofol on endotoxemia-induced acute kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Apoptosis; Aquaporins; bcl-2-Associated X Protein; Blood Urea Nitrogen | 2011 |
Effect of propofol on vascular reactivity in thoracic aortas from rats with endotoxemia.
Topics: Animals; Aorta, Thoracic; Calcium; Dose-Response Relationship, Drug; Endotoxemia; Lipopolysaccharide | 2012 |
Inhibition of S100A9 expression by propofol in monocytes of rats with endotoxemia.
Topics: Animals; Anti-Inflammatory Agents; Calgranulin B; Down-Regulation; Electrophoresis, Gel, Two-Dimensi | 2012 |
Differential influence of propofol on different cell types in terms of the expression of various oxidative stress-related enzymes in an experimental endotoxemia model.
Topics: Animals; Endotoxemia; Lung; Macrophages; Male; Myocytes, Cardiac; NADPH Oxidases; Nitric Oxide Synth | 2012 |
The influence of endotoxemia on the pharmacokinetics and the electroencephalographic effect of propofol in the rat.
Topics: Animals; Electroencephalography; Endotoxemia; Endotoxins; Male; Propofol; Rats; Rats, Wistar | 2003 |
Dose effects of propofol on hemodynamic and cytokine responses to endotoxemia in rats.
Topics: Anesthetics, Intravenous; Animals; Blood Gas Analysis; Cytokines; Dose-Response Relationship, Drug; | 2005 |
Attenuation of acute lung injury with propofol in endotoxemia.
Topics: Animals; Blood Pressure; Endotoxemia; Lung; Male; Nitric Oxide Synthase; Peroxynitrous Acid; Propofo | 2005 |
[The effect of posttreatment with isoflurane versus propofol on pulmonary alveolar capillary barrier in endotoxemic rats].
Topics: Animals; Blood-Air Barrier; Capillaries; Capillary Permeability; Endotoxemia; Isoflurane; Lipopolysa | 2005 |
Combined effects of propofol and dexamethasone on rats with endotoxemia.
Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; Drug Therapy, Combination; Endotoxemia; Male; Prop | 2008 |
Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats.
Topics: Animals; Drug Evaluation, Preclinical; Endotoxemia; Escherichia coli Infections; Hemodynamics; Hypno | 2000 |
Goldilocks and the three cytokines.
Topics: Animals; Cytokines; Drug Evaluation, Preclinical; Endotoxemia; Humans; Hypnotics and Sedatives; Immu | 2000 |
Not all propofol is created equal.
Topics: Animals; Chemistry, Pharmaceutical; Drug Carriers; Endotoxemia; Free Radical Scavengers; Humans; Hyp | 2001 |
Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock.
Topics: Anesthetics, Intravenous; Animals; Dinoprost; Endotoxemia; Escherichia coli Infections; F2-Isoprosta | 2001 |