propofol has been researched along with Encephalopathy, Toxic in 28 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propofol is a commonly used intravenous anesthetic agent for the induction and maintenance of anesthesia and procedural and critical care sedation in children." | 2.53 | Recent Insights Into Molecular Mechanisms of Propofol-Induced Developmental Neurotoxicity: Implications for the Protective Strategies. ( Bai, X; Bosnjak, ZJ; Liu, Y; Logan, S, 2016) |
| " Finally, the NSCs were pretreated with mitochondrial specific antioxidant (MitoQ) or Drp1 inhibitor (Mdivi-1), and then the toxic effects of propofol on NSCs were investigated." | 1.62 | The Role of Pink1-Mediated Mitochondrial Pathway in Propofol-Induced Developmental Neurotoxicity. ( Han, X; Liang, C; Miao, C; Sun, M; Zhong, J, 2021) |
| " While it is difficult to verify the adverse effects of long duration anesthetic exposure in infants and children, the utilization of relevant non-clinical models (i." | 1.56 | Protective Effects of Xenon on Propofol-Induced Neurotoxicity in Human Neural Stem Cell-Derived Models. ( Fogle, C; Hanig, JP; Liu, F; Liu, S; Patterson, TA; Slikker, W; Wang, C, 2020) |
| "Propofol treatment induces neurotoxicity and suppresses miR-455-3p levels in the developing hippocampal neurons." | 1.56 | miR-455-3p alleviates propofol-induced neurotoxicity by reducing EphA4 expression in developing neurons. ( He, Y; Li, H; Tian, M; Zhou, M; Zhou, S; Zhu, X, 2020) |
| "Propofol treatment also significantly decreased the number of CB-positive interneurons in the piriform cortex of mice on P21 and adulthood." | 1.51 | Neonatal exposure to propofol affects interneuron development in the piriform cortex and causes neurobehavioral deficits in adult mice. ( Bao, X; Cai, Y; Du, Z; Fan, X; Huang, J; Jing, S; Xiao, R; Yang, T; Yu, D, 2019) |
| "Propofol has been considered as a near-ideal anesthetic agent since its introduction 40 years ago." | 1.48 | The anti-apoptotic effect of nerve growth factor on propofol-induced neurotoxicity in hippocampal neurons is Rac1 dependent. ( Dong, Z; Huang, L; Kang, R; Li, X; Liu, X; Zhao, Z, 2018) |
| "Propofol is a widely used hypnotic agent for induction and maintenance of pediatric anesthesia with a well known safety profile." | 1.36 | Unexpected neurological sequelae following propofol anesthesia in infants: Three case reports. ( Bonafé, A; Echenne, B; Langlois, C; Leydet, J; Meyer, P; Rivier, F; Roubertie, A; Soëte, S, 2010) |
| "When propofol EDTA was given intravenously 10 mins before cerebral ischemia, the zinc concentration decreased significantly in the cortical area, but not in the subcortex." | 1.35 | Propofol exerts greater neuroprotection with disodium edetate than without it. ( Hara, H; Hasegawa, T; Iwama, T; Kotani, Y; Nagase, H; Nakajima, Y; Satoh, M; Shimazawa, M; Yoshimura, S, 2008) |
| " Etoposide phosphate in combination with any other agent was observed to be highly neurotoxic if both agents were administered after BBBD." | 1.31 | Unexpected neurotoxicity of etoposide phosphate administered in combination with other chemotherapeutic agents after blood-brain barrier modification to enhance delivery, using propofol for general anesthesia, in a rat model. ( Fortin, D; McCormick, CI; Neuwelt, EA; Nixon, R; Remsen, LG, 2000) |
| "Neurotoxicity is the dose-limiting side-effect of vincristine in cancer therapy." | 1.31 | Effect of thiopental, propofol, and etomidate on vincristine toxicity in PC12 cells. ( Chen, JT; Cheng, JT; Chou, AK; Lee, TC; Lin, CR; Lin, FC; Yang, LC, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (28.57) | 29.6817 |
| 2010's | 15 (53.57) | 24.3611 |
| 2020's | 5 (17.86) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, J | 1 |
| Li, Y | 1 |
| Liu, F | 1 |
| Liu, S | 1 |
| Patterson, TA | 1 |
| Fogle, C | 1 |
| Hanig, JP | 1 |
| Wang, C | 1 |
| Slikker, W | 1 |
| Zhu, X | 1 |
| Li, H | 1 |
| Tian, M | 1 |
| Zhou, S | 1 |
| He, Y | 1 |
| Zhou, M | 1 |
| Zhou, H | 1 |
| Xie, Z | 1 |
| Brambrink, AM | 1 |
| Yang, G | 1 |
| Liang, C | 1 |
| Sun, M | 1 |
| Zhong, J | 1 |
| Miao, C | 1 |
| Han, X | 1 |
| Ren, G | 1 |
| Zhou, Y | 1 |
| Liang, G | 2 |
| Yang, B | 1 |
| Yang, M | 2 |
| King, A | 1 |
| Wei, H | 2 |
| Pearn, ML | 1 |
| Schilling, JM | 1 |
| Jian, M | 1 |
| Egawa, J | 1 |
| Wu, C | 1 |
| Mandyam, CD | 1 |
| Fannon-Pavlich, MJ | 1 |
| Nguyen, U | 1 |
| Bertoglio, J | 1 |
| Kodama, M | 1 |
| Mahata, SK | 1 |
| DerMardirossian, C | 1 |
| Lemkuil, BP | 1 |
| Han, R | 1 |
| Mobley, WC | 1 |
| Patel, HH | 1 |
| Patel, PM | 1 |
| Head, BP | 1 |
| Berndt, N | 1 |
| Rösner, J | 1 |
| Haq, RU | 1 |
| Kann, O | 1 |
| Kovács, R | 1 |
| Holzhütter, HG | 1 |
| Spies, C | 1 |
| Liotta, A | 1 |
| Jiang, C | 1 |
| Logan, S | 2 |
| Yan, Y | 1 |
| Inagaki, Y | 1 |
| Arzua, T | 1 |
| Ma, P | 1 |
| Lu, S | 1 |
| Bosnjak, ZJ | 2 |
| Bai, X | 2 |
| Yu, D | 1 |
| Xiao, R | 1 |
| Huang, J | 1 |
| Cai, Y | 1 |
| Bao, X | 1 |
| Jing, S | 1 |
| Du, Z | 1 |
| Yang, T | 1 |
| Fan, X | 1 |
| Li, X | 1 |
| Zhao, Z | 1 |
| Huang, L | 1 |
| Kang, R | 1 |
| Liu, X | 1 |
| Dong, Z | 1 |
| Wang, Y | 1 |
| Xu, Z | 1 |
| Chu, CT | 1 |
| Creeley, C | 1 |
| Dikranian, K | 1 |
| Dissen, G | 1 |
| Martin, L | 1 |
| Olney, J | 1 |
| Brambrink, A | 1 |
| Kajimoto, M | 1 |
| Atkinson, DB | 1 |
| Ledee, DR | 1 |
| Kayser, EB | 1 |
| Morgan, PG | 1 |
| Sedensky, MM | 1 |
| Isern, NG | 1 |
| Des Rosiers, C | 1 |
| Portman, MA | 1 |
| Li, J | 1 |
| Xiong, M | 1 |
| Nadavaluru, PR | 1 |
| Zuo, W | 1 |
| Ye, JH | 1 |
| Eloy, JD | 1 |
| Bekker, A | 1 |
| Liu, Y | 1 |
| Wei, Y | 1 |
| Hu, J | 1 |
| Liang, Y | 1 |
| Zhong, Y | 1 |
| He, D | 1 |
| Qin, Y | 1 |
| Li, L | 1 |
| Chen, J | 1 |
| Xiao, Q | 1 |
| Xie, Y | 1 |
| Chen, B | 2 |
| Deng, X | 2 |
| Wang, B | 2 |
| Liu, H | 2 |
| Meyer, P | 1 |
| Langlois, C | 1 |
| Soëte, S | 1 |
| Leydet, J | 1 |
| Echenne, B | 1 |
| Rivier, F | 1 |
| Bonafé, A | 1 |
| Roubertie, A | 1 |
| Kati, I | 1 |
| Demirel, CB | 1 |
| Anlar, O | 1 |
| Hüseyinoglu, UA | 1 |
| Silay, E | 1 |
| Elcicek, K | 1 |
| Subramaniam, K | 1 |
| Gowda, RM | 1 |
| Rosa, U | 1 |
| Wang, YC | 1 |
| Liu, BM | 1 |
| Supernaw, RB | 1 |
| Lu, YH | 1 |
| Lee, PY | 1 |
| El-Beheiry, H | 1 |
| Kavanagh, B | 1 |
| Zimmer, C | 1 |
| Piepenbrink, K | 1 |
| Riest, G | 1 |
| Peters, J | 1 |
| Kotani, Y | 1 |
| Nakajima, Y | 1 |
| Hasegawa, T | 1 |
| Satoh, M | 1 |
| Nagase, H | 1 |
| Shimazawa, M | 1 |
| Yoshimura, S | 1 |
| Iwama, T | 1 |
| Hara, H | 1 |
| Fortin, D | 1 |
| McCormick, CI | 1 |
| Remsen, LG | 1 |
| Nixon, R | 1 |
| Neuwelt, EA | 1 |
| Lin, CR | 1 |
| Cheng, JT | 1 |
| Lin, FC | 1 |
| Chou, AK | 1 |
| Lee, TC | 1 |
| Chen, JT | 1 |
| Yang, LC | 1 |
2 reviews available for propofol and Encephalopathy, Toxic
| Article | Year |
|---|---|
Propofol-Induced Developmental Neurotoxicity: From Mechanisms to Therapeutic Strategies.
Topics: Anesthesia, General; Anesthetics, Intravenous; Child; Cognitive Dysfunction; Female; Humans; Infant; | 2023 |
Recent Insights Into Molecular Mechanisms of Propofol-Induced Developmental Neurotoxicity: Implications for the Protective Strategies.
Topics: Animals; Brain; Cells, Cultured; Humans; Hypnotics and Sedatives; Neuroprotective Agents; Neurotoxic | 2016 |
26 other studies available for propofol and Encephalopathy, Toxic
| Article | Year |
|---|---|
Protective Effects of Xenon on Propofol-Induced Neurotoxicity in Human Neural Stem Cell-Derived Models.
Topics: Apoptosis; Astrocytes; Cell Differentiation; Cells, Cultured; Humans; Neural Stem Cells; Neurons; Ne | 2020 |
miR-455-3p alleviates propofol-induced neurotoxicity by reducing EphA4 expression in developing neurons.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Cell Survival; Cells, Cultured; Down-Regulation; Hippo | 2020 |
Behavioural impairments after exposure of neonatal mice to propofol are accompanied by reductions in neuronal activity in cortical circuitry.
Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Behavior, Animal; Calcium Signaling; Elevated P | 2021 |
The Role of Pink1-Mediated Mitochondrial Pathway in Propofol-Induced Developmental Neurotoxicity.
Topics: Animals; Apoptosis; CDC2 Protein Kinase; Cell Differentiation; Cell Proliferation; Dynamins; Female; | 2021 |
General Anesthetics Regulate Autophagy via Modulating the Inositol 1,4,5-Trisphosphate Receptor: Implications for Dual Effects of Cytoprotection and Cytotoxicity.
Topics: Anesthetics, General; Animals; Apoptosis; Autophagy; Caspase 3; Cell Line; Chickens; Cytoprotection; | 2017 |
Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits.
Topics: Animals; Axonal Transport; Behavior, Animal; Botulinum Toxins; Brain; Disease Models, Animal; Growth | 2018 |
Possible neurotoxicity of the anesthetic propofol: evidence for the inhibition of complex II of the respiratory chain in area CA3 of rat hippocampal slices.
Topics: Adenosine Triphosphate; Anesthetics, Intravenous; Animals; CA3 Region, Hippocampal; Electron Transpo | 2018 |
Signaling network between the dysregulated expression of microRNAs and mRNAs in propofol-induced developmental neurotoxicity in mice.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Computational Biology; Gene Expression Profiling; Hipp | 2018 |
Neonatal exposure to propofol affects interneuron development in the piriform cortex and causes neurobehavioral deficits in adult mice.
Topics: Animals; Animals, Newborn; Behavior, Animal; Hypnotics and Sedatives; Interneurons; Learning; Male; | 2019 |
The anti-apoptotic effect of nerve growth factor on propofol-induced neurotoxicity in hippocampal neurons is Rac1 dependent.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Cell Differentiation; Cell Survival; Hippocampus; Nerv | 2018 |
Alzheimer's Disease Presenilin-1 Mutation Sensitizes Neurons to Impaired Autophagy Flux and Propofol Neurotoxicity: Role of Calcium Dysregulation.
Topics: Adenosine Triphosphatases; Alzheimer Disease; Anesthetics, Intravenous; Animals; Autophagy; Calcium | 2019 |
Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain.
Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Apoptosis; Brain; Female; Macaca mulatta; Neuro | 2013 |
Propofol compared with isoflurane inhibits mitochondrial metabolism in immature swine cerebral cortex.
Topics: Administration, Inhalation; Anesthetics, General; Animals; Animals, Newborn; Cerebral Cortex; Energy | 2014 |
Dexmedetomidine Attenuates Neurotoxicity Induced by Prenatal Propofol Exposure.
Topics: Anesthetics, Intravenous; Animals; Blotting, Western; Brain; Calcium-Binding Proteins; Caspase 3; De | 2016 |
Dexmedetomidine pretreatment attenuates propofol‑induced neurotoxicity in neuronal cultures from the rat hippocampus.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics, Intravenous; Animals; Animals, Newborn; Apoptosis | 2016 |
Persistent neuronal apoptosis and synaptic loss induced by multiple but not single exposure of propofol contribute to long-term cognitive dysfunction in neonatal rats.
Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; CA1 Region, Hippoc | 2016 |
Etanercept, an inhibitor of TNF-a, prevents propofol-induced neurotoxicity in the developing brain.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroida | 2016 |
Unexpected neurological sequelae following propofol anesthesia in infants: Three case reports.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Anticonvulsants; Brain; Cataract; Cataract Extrac | 2010 |
An unusual complication of total intravenous anesthesia: mutism.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Brain; Female; Femoral Fractures; Humans; Middle | 2003 |
Delayed neuroexcitatory symptoms following propofol sedation in a patient with polysubstance abuse.
Topics: Akathisia, Drug-Induced; Alcoholism; Conscious Sedation; Electroencephalography; Humans; Hypnotics a | 2003 |
Management of star fruit-induced neurotoxicity and seizures in a patient with chronic renal failure.
Topics: Aged, 80 and over; Anesthetics, Intravenous; Anticonvulsants; Coma; Fatal Outcome; Female; Fruit; Hu | 2006 |
Is propofol neurotoxic to the developing brain?
Topics: Anesthetics, Intravenous; Brain; Child; Child, Preschool; Female; Humans; Infant; Neurotoxicity Synd | 2006 |
[Cardiotoxic and neurotoxic effects after accidental intravascular bupivacaine administration. Therapy with lidocaine propofol and lipid emulsion].
Topics: Aged, 80 and over; Anesthesia, Epidural; Anesthetics, Intravenous; Anesthetics, Local; Blood Pressur | 2007 |
Propofol exerts greater neuroprotection with disodium edetate than without it.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Benzimidazoles; Brain Ischemia; Cell Count; Cell Survi | 2008 |
Unexpected neurotoxicity of etoposide phosphate administered in combination with other chemotherapeutic agents after blood-brain barrier modification to enhance delivery, using propofol for general anesthesia, in a rat model.
Topics: Anesthesia, General; Anesthetics, Intravenous; Animals; Antineoplastic Agents; Antineoplastic Combin | 2000 |
Effect of thiopental, propofol, and etomidate on vincristine toxicity in PC12 cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Bicuculline; Cytoprotection; Dose-Response Relationship, | 2002 |