propofol and Drug Overdose studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.

Research Excerpts

Excerpt	Relevance	Reference
"A 33-year-old previously healthy woman was admitted after a drug overdose combining colchicine, atorvastatin, ibuprofen, diclofenac, and furosemide."	7.76	Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management. ( Bonbled, F; Hantson, P; Huberlant, V; Montiel, V; Vincent, MF, 2010)
"An 18-year-old male developed a severe serotonin syndrome after recreational ingestion of Coricidin HBP (chlorpheniramine 4 mg and dextromethorphan hydrobromide 30 mg)."	7.74	Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy. ( Babu, KM; Boyer, EW; Ganetsky, M, 2007)
"A 33-year-old previously healthy woman was admitted after a drug overdose combining colchicine, atorvastatin, ibuprofen, diclofenac, and furosemide."	3.76	Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management. ( Bonbled, F; Hantson, P; Huberlant, V; Montiel, V; Vincent, MF, 2010)
"An 18-year-old male developed a severe serotonin syndrome after recreational ingestion of Coricidin HBP (chlorpheniramine 4 mg and dextromethorphan hydrobromide 30 mg)."	3.74	Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy. ( Babu, KM; Boyer, EW; Ganetsky, M, 2007)
"This case report discusses the cause of death in a 3-year-old child who survived a high dose (20 mg x kg-1 x h-1) of propofol, infused over a period of 15 h, following which the patient developed a combined respiratory and metabolic acidosis, the oxygenation remaining normal."	3.72	Death after re-exposure to propofol in a 3-year-old child: a case report. ( Aring, C; Gillor, A; Holzki, J, 2004)
" When sedation with benzodiazepines is carried out, the specific antagonist, flumazenil should always be available for use in emergencies such as accidental oversedation, iatrogenic overdose or paradoxical reactions."	3.69	Use of inhalational and intravenous sedation in dentistry. ( Rodrigo, MR, 1997)
"Propofol is a potent intravenous anesthetic agent that rapidly induces sedation and unconsciousness."	2.47	Clinical effects and lethal and forensic aspects of propofol. ( Levy, RJ, 2011)
"Treatment with carisoprodol and phenobarbital provided additional benefit and can be considered in cases of severe carisoprodol withdrawal."	1.46	Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose. ( Benowitz, NL; Horng, H; Smollin, CG; Vo, KT, 2017)
"Propofol was detected in 131 cases (0."	1.39	Deaths from recreational use of propofol in Korea. ( Baeck, S; Chung, H; Han, E; Jung, S; Lee, S, 2013)
"Propofol is a short acting intravenous anaesthetic, active agent of Diprivan."	1.35	Evaluation of a fatal propofol intoxication due to self administration. ( Klausz, G; Kristóf, I; Róna, K; Töro, K, 2009)
"Naloxone did not cause changes in ejection fraction or mean pulmonary artery pressure in hypoxic and hypercarbic conditions."	1.33	Cardiovascular changes after naloxone administration in propofol-sedated piglets during opioid overdose. ( Aittomäki, JV; Boyd, JJ; Kyttä, JV; Randell, TT; Rosenberg, PH; Seppälä, TA, 2006)
" Any adverse events were recorded."	1.32	Propofol target-controlled infusions for sedation--a safe technique for the non-anaesthetist? ( Blayney, MR; Malins, AF; Ryan, JD, 2003)
"Propofol was detected in tissues using high performance liquid chromatography."	1.28	A fatality due to propofol poisoning. ( Drummer, OH, 1992)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (10.81)	18.2507
2000's	20 (54.05)	29.6817
2010's	12 (32.43)	24.3611
2020's	1 (2.70)	2.80

Authors	Studies
Tsai, PB	1
Bergin, MW	1
Procaccianti, P	1
Farè, F	2
Argo, A	1
Casagni, E	2
Arnoldi, S	2
Facheris, S	1
Visconti, GL	2
Roda, G	2
Gambaro, V	2
Dei Cas, M	1
Ottaviano, V	1
Tregambe, F	1
Froldi, R	1
Mannocchi, G	1
Napoleoni, F	1
Napoletano, S	1
Pantano, F	1
Santoni, M	1
Tittarelli, R	1
Arbarello, P	1
Han, E	1
Jung, S	1
Baeck, S	1
Lee, S	1
Chung, H	1
Lin, MC	1
Lin, CF	1
Li, CF	1
Sun, DP	1
Wang, LY	1
Hsing, CH	1
Vo, KT	1
Horng, H	1
Smollin, CG	1
Benowitz, NL	1
Adams, BD	1
Barry, DJ	1
Kirby, RR	1
Colaw, JM	1
Douglas, MM	1
Klausz, G	1
Róna, K	1
Kristóf, I	1
Töro, K	1
Sammartino, M	1
Garra, R	1
Sbaraglia, F	1
Papacci, P	1
Levy, RJ	1
Froese, N	1
McVicar, J	1
Ansermino, M	1
Montiel, V	1
Huberlant, V	1
Vincent, MF	1
Bonbled, F	1
Hantson, P	1
Allegaert, K	1
Peeters, MY	1
Knibbe, C	1
Blayney, MR	1
Ryan, JD	1
Malins, AF	1
Rodrigo, C	1
Irwin, MG	1
Yan, BS	1
Wong, MH	1
Holzki, J	1
Aring, C	1
Gillor, A	1
Patermann, B	1
Buzello, S	1
Dück, M	1
Paul, M	1
Kampe, S	1
Mayr, VD	1
Raedler, C	1
Wenzel, V	1
Lindner, KH	1
Strohmenger, HU	1
Sundaram, R	1
Dell, AE	1
Crawford, D	1
Ghosh, I	1
Chaturvedi, A	1
Dash, HH	1
Foda, E	1
Bhaskaran, S	1
Kranioti, EF	1
Mavroforou, A	1
Mylonakis, P	1
Michalodimitrakis, M	1
Koch, C	1
Hollister, C	1
Breen, PH	1
Boyd, JJ	1
Kyttä, JV	1
Aittomäki, JV	1
Rosenberg, PH	1
Seppälä, TA	1
Randell, TT	1
Dawson, JS	1
da Cunha, AF	1
Carter, JE	1
Grafinger, M	1
Montgomery, H	1
Marks, SL	1
Posner, LP	1
Burns, P	1
Ganetsky, M	1
Babu, KM	1
Boyer, EW	1
Merigian, KS	1
Browning, RG	1
Leeper, KV	1
Buijs, EJ	1
van Zuylen, HJ	1
Rodrigo, MR	1
Sandler, NA	1
Sparks, BS	1
Iwersen-Bergmann, S	1
Rösner, P	1
Kühnau, HC	1
Junge, M	1
Schmoldt, A	1
Drummer, OH	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
An Observer Rating Scale of Facial Expression Can Predict Dreaming in Propofol Anesthesia[NCT04235894]				124 participants (Actual)	Observational	2016-09-07	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Clinical effects and lethal and forensic aspects of propofol. Journal of forensic sciences, 2011, Volume: 56 Suppl 1 Topics: Accidents; Acidosis; Acute Kidney Injury; Bacteremia; Bradycardia; Drug Overdose; Dyslipidemias; For	2011
Lethal self administration of propofol (Diprivan). A case report and review of the literature. Forensic science international, 2007, Mar-22, Volume: 167, Issue:1 Topics: Adult; Anesthetics, Intravenous; Anesthetics, Local; Drug Overdose; Female; Humans; Lidocaine; Liver	2007
Successful treatment of amoxapine-induced refractory status epilepticus with propofol (diprivan) Academic emergency medicine : official journal of the Society for Academic Emergency Medicine, 1995, Volume: 2, Issue:2 Topics: Adult; Amoxapine; Drug Overdose; Female; Humans; Infusions, Intravenous; Propofol; Status Epilepticu	1995

Article	Year
Unintentional Infiltration of High Dose Epinephrine in an Infant: A Case Report. A&A practice, 2020, Volume: 14, Issue:6 Topics: Blood Pressure; Drug Overdose; Epinephrine; Hemodynamics; Humans; Infant; Male; Medical Errors; Peri	2020
Determination of Propofol by GC/MS and Fast GC/MS-TOF in Two Cases of Poisoning. Journal of analytical toxicology, 2017, Nov-01, Volume: 41, Issue:9 Topics: Drug Overdose; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Homicide; Humans;	2017
Determination of Cyanide by Microdiffusion Technique Coupled to Spectrophotometry and GC/NPD and Propofol by Fast GC/MS-TOF in a Case of Poisoning. Journal of analytical toxicology, 2018, Jul-01, Volume: 42, Issue:6 Topics: Adult; Autopsy; Bile; Cause of Death; Chromatography, Gas; Drug Overdose; Fatal Outcome; Forensic To	2018
Fatal self administration of tramadol and propofol: a case report. Journal of forensic and legal medicine, 2013, Volume: 20, Issue:6 Topics: Analgesics, Opioid; Drug Overdose; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Hair;	2013
Deaths from recreational use of propofol in Korea. Forensic science international, 2013, Dec-10, Volume: 233, Issue:1-3 Topics: Adolescent; Adult; Drug Overdose; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry;	2013
[Incorrect programming of a target controlled infusion pump. Case SENSAR of the trimester]. Revista espanola de anestesiologia y reanimacion, 2014, Volume: 61, Issue:8 Topics: Anesthetics, General; Aortic Valve; Drug Overdose; Equipment Failure; Equipment Failure Analysis; He	2014
Anesthetic propofol overdose causes vascular hyperpermeability by reducing endothelial glycocalyx and ATP production. International journal of molecular sciences, 2015, May-27, Volume: 16, Issue:6 Topics: Adenosine Triphosphate; Anesthetics; Animals; Capillary Permeability; Cell Line; Cells, Cultured; Di	2015
Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose. The Journal of emergency medicine, 2017, Volume: 52, Issue:5 Topics: Adult; Carisoprodol; Dexmedetomidine; Drug Overdose; Fentanyl; Haloperidol; Humans; Hypnotics and Se	2017
Tiagabine: let seizing dogs lie? Emergency medicine Australasia : EMA, 2008, Volume: 20, Issue:4 Topics: Drug Overdose; Follow-Up Studies; Humans; Hypnotics and Sedatives; Nipecotic Acids; Propofol; Risk A	2008
Death from propofol: accident, suicide, or murder? Anesthesia and analgesia, 2009, Volume: 108, Issue:4 Topics: Anesthetics, Intravenous; Drug Labeling; Drug Overdose; Fatal Outcome; Female; Homicide; Humans; Inj	2009
Evaluation of a fatal propofol intoxication due to self administration. Journal of forensic and legal medicine, 2009, Volume: 16, Issue:5 Topics: Accidents; Drug Overdose; Female; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans;	2009
Propofol overdose in a preterm baby: may propofol infusion syndrome arise in two hours? Paediatric anaesthesia, 2010, Volume: 20, Issue:10 Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Gas Analysis; Blood Pressure; Drug Overdose	2010
Equipment limitations of a multichannel infusion pump. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2011, Volume: 58, Issue:1 Topics: Anesthesia, General; Anesthetics, Intravenous; Bronchoscopy; Drug Overdose; Equipment Failure; Human	2011
Multiple organ failure after an overdose of less than 0.4 mg/kg of colchicine: role of coingestants and drugs during intensive care management. Clinical toxicology (Philadelphia, Pa.), 2010, Volume: 48, Issue:8 Topics: Adult; Atorvastatin; Colchicine; Critical Care; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhib	2010
Propofol in (pre)term neonates: consider the extensive interindividual variability in clearance within the neonatal population. Paediatric anaesthesia, 2011, Volume: 21, Issue:2 Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Drug Overdose; Humans; Infant, Newborn; Infant, P	2011
Propofol target-controlled infusions for sedation--a safe technique for the non-anaesthetist? British dental journal, 2003, Apr-26, Volume: 194, Issue:8 Topics: Adolescent; Adult; Anesthesia, Dental; Anesthetics, Intravenous; Conscious Sedation; Dose-Response R	2003
Patient-controlled sedation with propofol in minor oral surgery. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2004, Volume: 62, Issue:1 Topics: Adolescent; Adult; Analgesia, Patient-Controlled; Anesthesia Recovery Period; Anesthesia, Dental; An	2004
Death after re-exposure to propofol in a 3-year-old child: a case report. Paediatric anaesthesia, 2004, Volume: 14, Issue:3 Topics: Acidosis; Child, Preschool; Drug Overdose; Fatal Outcome; Female; Humans; Hypnotics and Sedatives; P	2004
Accidental tenfold overdose of propofol in a 6-month old infant undergoing elective craniosynostosis repair. Anaesthesia, 2004, Volume: 59, Issue:9 Topics: Anesthetics, Intravenous; Cardiac Output, Low; Craniosynostoses; Drug Overdose; Humans; Infant; Intr	2004
Lipid, not propofol, treats bupivacaine overdose. Anesthesia and analgesia, 2004, Volume: 99, Issue:6 Topics: Anesthetics, Intravenous; Anesthetics, Local; Animals; Bupivacaine; Dogs; Drug Overdose; Fat Emulsio	2004
Interaction between infusion equipment resulting in drug overdose in a critically ill patient. Anaesthesia, 2005, Volume: 60, Issue:1 Topics: Acute Kidney Injury; Adolescent; Analgesics, Opioid; Critical Illness; Drug Overdose; Equipment Fail	2005
A response to 'Accidental tenfold overdose of propofol in a 6-month old infant undergoing elective craniosynostosis repair', Patermann B, Buzello S, Duck M, Paul M, Kampe S, Anaesthesia 2004; 59: 912-4. Anaesthesia, 2005, Volume: 60, Issue:1 Topics: Anesthetics, Intravenous; Craniosynostoses; Drug Overdose; Humans; Intraoperative Complications; Med	2005
Overdose of propofol in a child. Anaesthesia, 2005, Volume: 60, Issue:6 Topics: Anesthetics, Intravenous; Child, Preschool; Drug Overdose; Humans; Infant; Intraoperative Complicati	2005
Overdose of propofol in a child. Anaesthesia, 2006, Volume: 61, Issue:1 Topics: Anesthetics, Intravenous; Child, Preschool; Drug Overdose; Humans; Infant; Intraoperative Complicati	2006
Infusion pump delivers over-dosage of propofol as a result of missing syringe support. Anesthesia and analgesia, 2006, Volume: 102, Issue:4 Topics: Drug Delivery Systems; Drug Overdose; Equipment Failure; Female; Humans; Infusion Pumps; Infusions,	2006
Cardiovascular changes after naloxone administration in propofol-sedated piglets during opioid overdose. Acta anaesthesiologica Scandinavica, 2006, Volume: 50, Issue:10 Topics: Analgesics, Opioid; Animals; Carbon Dioxide; Cardiovascular Physiological Phenomena; Catecholamines;	2006
Lipid emulsions for local anaesthetic toxicity. Anaesthesia, 2006, Volume: 61, Issue:12 Topics: Anesthetics, Local; Antidotes; Drug Administration Schedule; Drug Overdose; Fat Emulsions, Intraveno	2006
Intrathecal morphine overdose in a dog. Journal of the American Veterinary Medical Association, 2007, Jun-01, Volume: 230, Issue:11 Topics: Animals; Atracurium; Diazepam; Dog Diseases; Dogs; Drug Overdose; Epilepsies, Myoclonic; Female; Inf	2007
Serotonin syndrome in dextromethorphan ingestion responsive to propofol therapy. Pediatric emergency care, 2007, Volume: 23, Issue:11 Topics: Acetaminophen; Adolescent; Algorithms; Chlorpheniramine; Dextromethorphan; Drug Combinations; Drug O	2007
Metabolic consequences of a sorbitol overdose during neurosurgery. Journal of neurosurgical anesthesiology, 1997, Volume: 9, Issue:1 Topics: Acidosis, Lactic; Adenosine Diphosphate; Adenosine Triphosphate; Anesthesia, General; Anesthetics, G	1997
Use of inhalational and intravenous sedation in dentistry. International dental journal, 1997, Volume: 47, Issue:1 Topics: Accidents; Anesthesia, Dental; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Local; A	1997
Death after excessive propofol abuse. International journal of legal medicine, 2001, Volume: 114, Issue:4-5 Topics: Adult; Anesthetics, Intravenous; Autopsy; Drug Overdose; Humans; Male; Propofol; Reference Standards	2001
A fatality due to propofol poisoning. Journal of forensic sciences, 1992, Volume: 37, Issue:4 Topics: Accidents; Adult; Chromatography, High Pressure Liquid; Drug Overdose; Female; Gas Chromatography-Ma	1992

propofol and Drug Overdose

Research Excerpts

Research

Studies (37)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies