propofol has been researched along with Disease Models, Animal in 218 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propofol has recently attracted increasing attention for its anti-tumor property in cancers, including glioma." | 8.31 | Propofol Suppresses Glioma Tumorigenesis by Regulating circ_0047688/miR-516b-5p/IFI30 Axis. ( Li, J; Li, Y; Liu, Y; Shu, Y; Zhang, J, 2023) |
| " Here we aim to explore the immunomodulatory roles of two common anesthetics, propofol and sevoflurane in breast cancer progression." | 8.31 | Immunomodulatory roles of propofol and sevoflurane in murine models of breast cancer. ( Ma, X; Song, T; Tian, J; Wang, W; Yan, R, 2023) |
| "Acute ischemic stroke is associated with pulmonary complications, and often dexmedetomidine and propofol are used to decrease cerebral metabolic rate." | 8.02 | Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke. ( Antunes, MA; Battaglini, D; Cruz, FF; da Silva, CM; Fernandes, MV; Pelosi, P; Robba, C; Rocco, PRM; Samary, CS; Silva, PL; Sousa, GC; Takyia, C, 2021) |
| "Propofol (PPF) is reported to play a protective role in ischemia/reperfusion (I/R) injury, including cerebral ischemia-reperfusion injury (CIRI)." | 8.02 | Propofol Downregulates lncRNA MALAT1 to Alleviate Cerebral Ischemia-Reperfusion Injury. ( Chen, J; Cheng, S; Hu, Y; Ye, C, 2021) |
| "The aim of this study was to investigate the effects of propofol on intestinal ischemia-reperfusion injury in rats through the nuclear factor-kappa B (NF-κB) pathway." | 7.96 | Propofol improves intestinal ischemia-reperfusion injury in rats through NF-κB pathway. ( Cui, SM; He, SC; Ma, B; Wu, MB; Zhang, TX; Zhao, K, 2020) |
| "There is conflicting evidence regarding the impact of propofol on cardiac repolarization and the risk of torsade de pointes (TdP)." | 7.96 | Propofol abolishes torsade de pointes in different models of acquired long QT syndrome. ( Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Könemann, H; Rath, B; Reinke, F; Wegner, FK; Willy, K; Wolfes, J, 2020) |
| "Propofol significantly reduces neurological dysfunction, BBB permeability, brain edema, inflammation, and oxidative stress, all of which were reversed by LY294002." | 7.91 | Propofol Reduces Inflammatory Brain Injury after Subarachnoid Hemorrhage: Involvement of PI3K/Akt Pathway. ( Chen, Q; Shi, SS; Tu, XK; Zhang, HB, 2019) |
| "BACKGROUND This study aimed to investigate the molecular mechanisms associated with the effects of propofol in a rat model of pain due to inflammation following subcutaneous injection with complete Freund's adjuvant (CFA)." | 7.91 | The Molecular Mechanisms Associated with the Effects of Propofol in a Rat Model of Pain Due to Inflammation Following Injection with Complete Freund's Adjuvant. ( Liu, H; Tan, S; Wang, Y; Zhu, S, 2019) |
| "Both propofol and sevoflurane attenuated the extent of hepatic ischemia/reperfusion injury which is evident from the hisopathological studies and alterations in liver enzymes such as AST and LDH by inhibiting Nuclear factor kappa B (NFx03BA;B) activation and subsequent alterations in inflammatory cytokines interleukin-1(IL-1), interleukin-6(IL-6), tumor necrosis factor-alpha (TNF-α) and increased IL10 release." | 7.83 | The Effects of Two Anesthetics, Propofol and Sevoflurane, on Liver Ischemia/Reperfusion Injury. ( Qi, F; Wang, H; Wang, Z; Wu, J; Xu, Z; Yu, J, 2016) |
| "Propofol is a commonly used intravenous anesthetic that has been demonstrated to be neuroprotective against cerebral ischemia-reperfusion (I/R) injury." | 7.81 | Propofol prevents neuronal mtDNA deletion and cerebral damage due to ischemia/reperfusion injury in rats. ( Chang, FF; Dong, H; Liu, Y; Lu, SJ; Qian, H; Song, CY; Wang, YF; Yang, WC; Yue, ZY, 2015) |
| "It has been shown in our previous study that propofol postconditioning enhanced the activity of phosphatidylinositol-3-kinase (PI3K) and prevented the internalization of GluR2 subunit of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thus provided neuroprotection in cerebral ischemia/reperfusion (I/R) injury." | 7.81 | The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats. ( Liu, S; Wang, G; Wang, H; Zhu, A, 2015) |
| "This is the first study to assess prolonged effects of sepsis and long-term application of volatile sedatives compared to propofol on survival, cardiovascular, inflammatory and end organ parameters." | 7.81 | Propofol increases morbidity and mortality in a rat model of sepsis. ( Beck-Schimmer, B; Bonini, MG; Dull, RO; Mao, M; Minshall, RD; Piegeler, T; Schläpfer, M; Schwartz, DE; Z'Graggen, BR, 2015) |
| "This study aimed to investigate whether propofol pretreatment can protect against liver transplantation-induced acute lung injury (ALI) and to explore whether Nrf2 pathway is involved in the protections provided by propofol pretreatment." | 7.80 | Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model. ( Chi, X; Hei, Z; Luo, G; Xia, Z; Yao, W; Zhang, A; Zhu, G, 2014) |
| "To observe the effects of continuous sedation with propofol on peripheral blood mononuclear cell (PBMC) and intercellular adhesion molecule 1 (ICAM-1) in beagles with combined burn-blast injuries." | 7.80 | [Effects of continuous sedation with propofol on peripheral blood mononuclear cell and intercellular adhesion molecule in beagles with combined burn-blast injuries]. ( Hou, Y; Hu, Q; Liu, L; Luo, H; Wang, Y; Yang, H, 2014) |
| "We evaluated whether the short-term use of dexmedetomidine and propofol may attenuate inflammatory response and improve lung morphofunction in experimental acute lung injury (ALI)." | 7.80 | Effects of short-term propofol and dexmedetomidine on pulmonary morphofunction and biological markers in experimental mild acute lung injury. ( Araújo, MN; Cavalcanti, V; Fernandes, FC; Heil, LB; Morales, MM; Pelosi, P; Rocco, PR; Samary, CS; Santos, CL; Silva, PL; Villela, N, 2014) |
| "Sixty rats were randomly assigned to four groups: normoglycemia-etomidate, normoglycemia-propofol, hyperglycemia-etomidate, and hyperglycemia-propofol." | 7.79 | Propofol attenuates renal ischemia-reperfusion injury aggravated by hyperglycemia. ( Jun, JH; Kwak, YL; Lim, BJ; Shim, JK; Yoo, KJ; Yoo, YC, 2013) |
| " Propofol's disadvantages include the induction of respiratory depression and apnea." | 7.79 | Coadministration of the AMPAKINE CX717 with propofol reduces respiratory depression and fatal apneas. ( Ding, X; Greer, JJ; Lenal, F; Ren, J; Yang, M, 2013) |
| "The goal of this study was to confirm whether or not sevoflurane is more effective than propofol in ameliorating the inflammatory response in an animal model of acute respiratory distress syndrome." | 7.79 | Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study. ( Aguilar, G; Belda, FJ; Ferrando, C; Moreno, J; Piqueras, L; Soro, M, 2013) |
| "This experimental study aimed to investigate the antioxidant effects of propofol anesthesia at induction doses in a rat skeletal muscle ischemia/reperfusion injury model." | 7.78 | Antioxidant effects of propofol on tourniquet-induced ischemia-reperfusion injury: an experimental study. ( Bostan, B; Erkorkmaz, U; Ozkan, F; Ozyurt, H; Senayli, Y, 2012) |
| " To test our hypothesis that anesthetics interact with the intrinsic parameters of ECT to differentially regulate its therapeutic efficacy, we investigated the effects of the anesthetic propofol and the stimulus intensities of ECT on behavior and hippocampal brain-derived neurotrophic factor (BDNF) in a rodent model of depression." | 7.78 | Propofol interacts with stimulus intensities of electroconvulsive shock to regulate behavior and hippocampal BDNF in a rat model of depression. ( Liu, Y; Luo, J; Min, S; Wei, K; Zhang, J, 2012) |
| "Propofol has been demonstrated to improve hepatic perfusion in a rabbit model; however, the effects of propofol on hepatic ischemia/reperfusion injury are unknown." | 7.78 | Propofol attenuates hepatic ischemia/reperfusion injury in an in vivo rabbit model. ( Luo, CZ; McCluskey, SA; Pang, QY; Ye, L; Zhu, T, 2012) |
| "Monitoring of exhaled pentane may be useful for evaluating the severity of hepatic ischemia-reperfusion injury and aid in predicting the outcome; propofol may improve the outcome in this situation." | 7.78 | Breath pentane as a potential biomarker for survival in hepatic ischemia and reperfusion injury--a pilot study. ( Gong, Y; He, Y; Li, E; Li, J; Li, P; Liu, D; Liu, S; Luo, A; Shi, J; Sun, B; Wang, C; Xu, G, 2012) |
| "To explore the effects of propofol on the outcomes of rats with sepsis." | 7.77 | Effects of propofol on the outcomes of rats with sepsis. ( Bao, HG; Li, S, 2011) |
| "To observe the influence of propofol on corticosteroid, and cytokines in rats after hemorrhagic shock and resuscitation, as well as its protective effects on vital organs." | 7.75 | [The influences of propofol on corticosteroid and immunity of rats after hemorrhagic shock and resuscitation]. ( Cao, SH; Ji, X, 2009) |
| " Although its mechanism of smooth muscle relaxation is unknown, propofol has been associated with less bronchoconstriction during anaesthetic induction." | 7.74 | Investigation of the relaxant effects of propofol on ovalbumin-induced asthma in guinea pigs. ( Bagcivan, I; Cevit, O; Gursoy, S; Kaya, T; Mimaroglu, C; Yildirim, MK; Yildirim, S, 2007) |
| "We previously found that propofol attenuated the mortality rate and inflammatory responses during endotoxemia in rats; however, whether propofol retains its antiinflammatory effects during hypothermia has not been determined." | 7.74 | The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia. ( Kanakura, H; Taniguchi, T, 2007) |
| "We have previously demonstrated, in the isolated rat heart, that propofol attenuates hydrogen peroxide-induced damage and ischaemia-reperfusion injury, and that the beneficial effect of propofol is correlated with reduction of the lipid peroxidation." | 7.74 | Propofol attenuates ischaemia-reperfusion injury in the rat heart in vivo. ( Kobayashi, I; Kokita, N; Namiki, A, 2008) |
| "To study the therapeutic effect and its mechanisms of propofol on gastric mucosal injury after hemorrhagic shock with reperfusion in rabbits." | 7.74 | [Effect of propofol on gastric mucosal injury after hemorrhagic shock and reperfusion in rabbits]. ( Li, HY; Lü, YX; Wang, LL; Zhang, LF, 2008) |
| "To explore whether propofol plays a protective role in kidney injury during acute respiratory distress syndrome (ARDS) by affecting the expression of Gq/11 protein." | 7.73 | [Influence of propofol on Gq/11 protein in kidney during acute respiratory distress syndrome]. ( Abasi, K; Jialili, A; Li, XJ; Zhang, L, 2006) |
| "Although TIVA is less prone than isoflurane anaesthesia to primary cardiovascular depression leading to asphyxia, TIVA is associated with reduced effectiveness of CPR in which resuscitation because of asphyxic haemodynamic depression occurs." | 7.72 | Comparison of isoflurane and propofol-fentanyl anaesthesia in a swine model of asphyxia. ( Kazama, T; Kurita, T; Morita, K; Sato, S, 2003) |
| "Propofol in this model was more arrhythmogenic than thiopental, as manifested by a longer duration of induced arrhythmias, particularly AFI." | 7.72 | Comparative effects of thiopental and propofol on atrial vulnerability: electrophysiological study in a porcine model including acute alcoholic intoxication. ( Almendral, J; Anadón, MJ; González, P; Navia, J; Zaballos, M, 2004) |
| "Intrathecal administration of propofol had analgesic effects on inflammation-induced acute and facilitated pain but not on thermally-induced acute pain." | 7.72 | Intrathecal propofol has analgesic effects on inflammation-induced pain in rats. ( Hanaoka, K; Matsukawa, T; Nishiyama, T, 2004) |
| "To compare the effects of pentobarbital and propofol on the outcome of focal cerebral ischemia model, and to evaluate the availability of propofol in setting the focal cerebral ischemia." | 7.72 | [Comparison of pentobarbital and propofol on the outcome of focal cerebral ischemia model in rats]. ( Kang, QY; Li, J; Liu, Y; Zhang, PB; Zhao, JJ, 2004) |
| "We investigated the effects of selective and non-selective endothelin (ET) antagonists on warm ischemia-reperfusion injury of the early phase in the murine liver under propofol anesthesia." | 7.70 | [Effects of endothelin antagonists on isolated perfused murine livers in the early phase of warm ischemia-reperfusion injury under propofol anesthesia]. ( Karasawa, F; Sato, T; Tanaka, K, 1999) |
| "It has been suggested that propofol has the protective effect on cerebral ischemia-reperfusion injury." | 7.70 | Effectiveness of propofol pretreatment on the extent of deranged cerebral mitochondrial oxidative enzyme system after incomplete forebrain ischemia/reperfusion in rats. ( Chung, C; Lee, Y; Oh, YS, 2000) |
| "Propofol is an intravenous anesthetic that is commonly used during intravascular embolectomy following acute ischemic stroke." | 5.56 | Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke. ( Cui, V; Tian, D; Wang, H; Wang, Y; Wei, C; Wu, A; Yue, Y; Zhu, Y, 2020) |
| "Propofol was injected for anesthesia (n = 22)." | 5.48 | The recovery from transient cognitive dysfunction induced by propofol was associated with enhanced autophagic flux in normal healthy adult mice. ( Baik, HJ; Cho, S; Han, JI; Jung, YJ; Lee, GY; Lee, KE; Suh, EC, 2018) |
| "Propofol is an intravenous sedative-hypnotic agent that is commonly used to induce and maintain general anaesthesia." | 5.43 | Effects of Propofol on Oxidative Stress Parameters in Selected Parts of the Brain in a Rat Model of Parkinson Disease. ( Birkner, E; Chwalińska, E; Hudziec, E; Nowak, P; Prudel, B; Romuk, E; Skowron, M; Szczurek, W, 2016) |
| "Propofol is a short-acting, intravenous general anesthetic that is widely used in clinical practice for short procedures; however, it causes depressed cognitive function for several hours thereafter." | 5.40 | (R)-alpha-methylhistamine suppresses inhibitory neurotransmission in hippocampal CA1 pyramidal neurons counteracting propofol-induced amnesia in rats. ( Cheng, LZ; Li, WW; Raya, AD; Shi, XY; Tian, ML; Wang, Y; Zhang, H; Zou, Z, 2014) |
| "Propofol treatment reduced infarct volume and improved the neurological functions." | 5.39 | Propofol protects against focal cerebral ischemia via inhibition of microglia-mediated proinflammatory cytokines in a rat model of experimental stroke. ( Liu, F; Tan, Y; Tang, X; Wu, X; Yang, Z; Zhou, R, 2013) |
| "Pretreatment with propofol significantly decreased writhing responses induced by visceral pain, suppressed the visceral pain-induced aspartate and glutamate release, and reversed the decreased release of γ-amino butyric acid in the cerebrospinal fluid." | 5.36 | Effects of anesthetic propofol on release of amino acids from the spinal cord during visceral pain. ( Fang, L; Liu, Y; Mu, X; Wang, Y; Wu, A; Wu, J; Yue, Y; Zhang, Y, 2010) |
| "Propofol has inhibited the hepatic NF-kappaB activation and the pro-inflammatory cytokine response during polymicrobial sepsis in rats." | 5.35 | Effects of propofol on pro-inflammatory cytokines and nuclear factor kappaB during polymicrobial sepsis in rats. ( Li, JG; Liang, H; Song, XM; Wang, CY; Wang, YL; Zhang, ZZ; Zhou, Q, 2009) |
| "Rats underwent 2 h of middle cerebral artery occlusion (MCAO) followed by 22 h of reperfusion were randomly divided into nine groups (n=15 each): sham-operated group, MCAO group, propofol 10, 20 and 35 mg x kg(-1) x h(-1) group (propofol 10, 20, 35 mg x kg(-1) x h(-1) infused at the onset of reperfusion for 30 min), wortmannin group (wortmannin 0." | 5.35 | The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats. ( Wang, GL; Wang, HY; Wang, Y; Yu, YH, 2009) |
| "Propofol has been demonstrated to ameliorate cerebral ischemic injury and attenuate changes in multiple links of molecular reaction included in the paths to apoptosis." | 5.35 | Effect of propofol on pathologic time-course and apoptosis after cerebral ischemia-reperfusion injury. ( Chen, L; Jiang, H; Xue, Z, 2008) |
| "Status epilepticus is commonly refractory to first-line therapy, and thus better treatments are needed." | 5.31 | Propofol in subanesthetic doses terminates status epilepticus in a rodent model. ( Holtkamp, M; Tong, X; Walker, MC, 2001) |
| " Morphine, pethidine and fentanyl, which showed a biphasic dose-response relationship with respect to seizure modulation, abolished the anticonvulsant activity of propofol to exhibit their own intrinsic activity in proconvulsant doses." | 5.29 | Interactions between opioid drugs and propofol in laboratory models of seizures. ( Ahmad, I; Pleuvry, BJ, 1995) |
| "Propofol has recently attracted increasing attention for its anti-tumor property in cancers, including glioma." | 4.31 | Propofol Suppresses Glioma Tumorigenesis by Regulating circ_0047688/miR-516b-5p/IFI30 Axis. ( Li, J; Li, Y; Liu, Y; Shu, Y; Zhang, J, 2023) |
| " Here we aim to explore the immunomodulatory roles of two common anesthetics, propofol and sevoflurane in breast cancer progression." | 4.31 | Immunomodulatory roles of propofol and sevoflurane in murine models of breast cancer. ( Ma, X; Song, T; Tian, J; Wang, W; Yan, R, 2023) |
| "Sedation with propofol or dexmedetomidine starting at return of spontaneous circulation improved survival in hypothermia-treated mice (propofol [13 of 16, 81%] vs." | 4.12 | Post-cardiac arrest Sedation Promotes Electroencephalographic Slow-wave Activity and Improves Survival in a Mouse Model of Cardiac Arrest. ( Amorim, E; Ichinose, F; Ikeda, T; Kato, R; Malhotra, R; Marutani, E; Miyazaki, Y; Silverman, MG; Solt, K, 2022) |
| "Acute ischemic stroke is associated with pulmonary complications, and often dexmedetomidine and propofol are used to decrease cerebral metabolic rate." | 4.02 | Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke. ( Antunes, MA; Battaglini, D; Cruz, FF; da Silva, CM; Fernandes, MV; Pelosi, P; Robba, C; Rocco, PRM; Samary, CS; Silva, PL; Sousa, GC; Takyia, C, 2021) |
| "Delayed emergence from anesthesia was previously reported in a case study of a child with Glycine Encephalopathy." | 4.02 | Elevated preoptic brain activity in zebrafish glial glycine transporter mutants is linked to lethargy-like behaviors and delayed emergence from anesthesia. ( Bindernagel, R; Buglo, E; Dallman, JE; Engert, F; Kelz, MB; Meng, QC; Randlett, O; Sloan, SA; Stark, MJ; Sumathipala, SH; Syed, S; Venincasa, MJ; Yan, Q; Züchner, S, 2021) |
| "Propofol (PPF) is reported to play a protective role in ischemia/reperfusion (I/R) injury, including cerebral ischemia-reperfusion injury (CIRI)." | 4.02 | Propofol Downregulates lncRNA MALAT1 to Alleviate Cerebral Ischemia-Reperfusion Injury. ( Chen, J; Cheng, S; Hu, Y; Ye, C, 2021) |
| " Here we show that surgical dissection of primary tumors in mice under anesthesia with sevoflurane leads to significantly more lung metastasis than with propofol in both syngeneic murine 4T1 and xenograft human MDA-MB-231 breast cancer models." | 3.96 | Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models. ( Huang, Y; Li, R; Lin, J, 2020) |
| "The aim of this study was to investigate the effects of propofol on intestinal ischemia-reperfusion injury in rats through the nuclear factor-kappa B (NF-κB) pathway." | 3.96 | Propofol improves intestinal ischemia-reperfusion injury in rats through NF-κB pathway. ( Cui, SM; He, SC; Ma, B; Wu, MB; Zhang, TX; Zhao, K, 2020) |
| "There is conflicting evidence regarding the impact of propofol on cardiac repolarization and the risk of torsade de pointes (TdP)." | 3.96 | Propofol abolishes torsade de pointes in different models of acquired long QT syndrome. ( Dechering, DG; Eckardt, L; Ellermann, C; Frommeyer, G; Könemann, H; Rath, B; Reinke, F; Wegner, FK; Willy, K; Wolfes, J, 2020) |
| "Propofol significantly reduces neurological dysfunction, BBB permeability, brain edema, inflammation, and oxidative stress, all of which were reversed by LY294002." | 3.91 | Propofol Reduces Inflammatory Brain Injury after Subarachnoid Hemorrhage: Involvement of PI3K/Akt Pathway. ( Chen, Q; Shi, SS; Tu, XK; Zhang, HB, 2019) |
| "Taken together, propofol contributed to liver protection against d-GalN/LPS-induced liver injury in mice by inhibiting inflammation, oxidative stress and hepatocyte apoptosis through regulating TLR4/NF-κB/NLRP3 pathway." | 3.91 | Propofol attenuates inflammatory response and apoptosis to protect d-galactosamine/lipopolysaccharide induced acute liver injury via regulating TLR4/NF-κB/NLRP3 pathway. ( Jiang, K; Tian, L; Zhang, Z, 2019) |
| "BACKGROUND This study aimed to investigate the molecular mechanisms associated with the effects of propofol in a rat model of pain due to inflammation following subcutaneous injection with complete Freund's adjuvant (CFA)." | 3.91 | The Molecular Mechanisms Associated with the Effects of Propofol in a Rat Model of Pain Due to Inflammation Following Injection with Complete Freund's Adjuvant. ( Liu, H; Tan, S; Wang, Y; Zhu, S, 2019) |
| "After approval by the institutional animal care and use committee, 36 Japanese White rabbits underwent partial hepatic ischemia for 90 min either under sevoflurane or propofol anesthesia." | 3.88 | Interaction between anesthetic conditioning and ischemic preconditioning on metabolic function after hepatic ischemia-reperfusion in rabbits. ( Kosugi, S; Kotake, Y; Morisaki, H; Nagata, H; Suzuki, T; Yamada, T, 2018) |
| "In animal models, both sevoflurane and propofol protect against acute lung injury (ALI), especially when administered prior to ALI onset." | 3.85 | Sevoflurane Posttreatment Attenuates Lung Injury Induced by Oleic Acid in Dogs. ( Du, G; Li, Z; Liu, J; Wang, S, 2017) |
| "Both propofol and sevoflurane attenuated the extent of hepatic ischemia/reperfusion injury which is evident from the hisopathological studies and alterations in liver enzymes such as AST and LDH by inhibiting Nuclear factor kappa B (NFx03BA;B) activation and subsequent alterations in inflammatory cytokines interleukin-1(IL-1), interleukin-6(IL-6), tumor necrosis factor-alpha (TNF-α) and increased IL10 release." | 3.83 | The Effects of Two Anesthetics, Propofol and Sevoflurane, on Liver Ischemia/Reperfusion Injury. ( Qi, F; Wang, H; Wang, Z; Wu, J; Xu, Z; Yu, J, 2016) |
| "BACKGROUND The present study explored the effects of propofol on hippocampal autophagy and synaptophysin in depression-model rats undergoing electroconvulsive shock (ECS)." | 3.83 | Propofol Mitigates Learning and Memory Impairment After Electroconvulsive Shock in Depressed Rats by Inhibiting Autophagy in the Hippocampus. ( Hao, XC; Li, P; Luo, J; Lv, F; Min, S; Wei, K, 2016) |
| "Propofol is a commonly used intravenous anesthetic that has been demonstrated to be neuroprotective against cerebral ischemia-reperfusion (I/R) injury." | 3.81 | Propofol prevents neuronal mtDNA deletion and cerebral damage due to ischemia/reperfusion injury in rats. ( Chang, FF; Dong, H; Liu, Y; Lu, SJ; Qian, H; Song, CY; Wang, YF; Yang, WC; Yue, ZY, 2015) |
| "It has been shown in our previous study that propofol postconditioning enhanced the activity of phosphatidylinositol-3-kinase (PI3K) and prevented the internalization of GluR2 subunit of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thus provided neuroprotection in cerebral ischemia/reperfusion (I/R) injury." | 3.81 | The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats. ( Liu, S; Wang, G; Wang, H; Zhu, A, 2015) |
| "This is the first study to assess prolonged effects of sepsis and long-term application of volatile sedatives compared to propofol on survival, cardiovascular, inflammatory and end organ parameters." | 3.81 | Propofol increases morbidity and mortality in a rat model of sepsis. ( Beck-Schimmer, B; Bonini, MG; Dull, RO; Mao, M; Minshall, RD; Piegeler, T; Schläpfer, M; Schwartz, DE; Z'Graggen, BR, 2015) |
| " The effects of isoflurane, propofol, apnea, and hypotension on lower extremity MEPs were studied." | 3.81 | Methodology of motor evoked potentials in a rabbit model. ( Bombien, R; Goodwin, E; Haji, F; Juan, V; Khoynezhad, A; Lapchak, PA; Rastegar, M; Waterford, SD, 2015) |
| "The natural compounds carvacrol and thymol completely prevented seizures in the 6 Hz, 32 mA partial seizure model." | 3.80 | Seizure prevention by the naturally occurring phenols, carvacrol and thymol in a partial seizure-psychomotor model. ( Baker, MT; Mishra, RK, 2014) |
| "This study aimed to investigate whether propofol pretreatment can protect against liver transplantation-induced acute lung injury (ALI) and to explore whether Nrf2 pathway is involved in the protections provided by propofol pretreatment." | 3.80 | Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model. ( Chi, X; Hei, Z; Luo, G; Xia, Z; Yao, W; Zhang, A; Zhu, G, 2014) |
| "To observe the effects of continuous sedation with propofol on peripheral blood mononuclear cell (PBMC) and intercellular adhesion molecule 1 (ICAM-1) in beagles with combined burn-blast injuries." | 3.80 | [Effects of continuous sedation with propofol on peripheral blood mononuclear cell and intercellular adhesion molecule in beagles with combined burn-blast injuries]. ( Hou, Y; Hu, Q; Liu, L; Luo, H; Wang, Y; Yang, H, 2014) |
| "We evaluated whether the short-term use of dexmedetomidine and propofol may attenuate inflammatory response and improve lung morphofunction in experimental acute lung injury (ALI)." | 3.80 | Effects of short-term propofol and dexmedetomidine on pulmonary morphofunction and biological markers in experimental mild acute lung injury. ( Araújo, MN; Cavalcanti, V; Fernandes, FC; Heil, LB; Morales, MM; Pelosi, P; Rocco, PR; Samary, CS; Santos, CL; Silva, PL; Villela, N, 2014) |
| "Sixty rats were randomly assigned to four groups: normoglycemia-etomidate, normoglycemia-propofol, hyperglycemia-etomidate, and hyperglycemia-propofol." | 3.79 | Propofol attenuates renal ischemia-reperfusion injury aggravated by hyperglycemia. ( Jun, JH; Kwak, YL; Lim, BJ; Shim, JK; Yoo, KJ; Yoo, YC, 2013) |
| " Propofol's disadvantages include the induction of respiratory depression and apnea." | 3.79 | Coadministration of the AMPAKINE CX717 with propofol reduces respiratory depression and fatal apneas. ( Ding, X; Greer, JJ; Lenal, F; Ren, J; Yang, M, 2013) |
| "The goal of this study was to confirm whether or not sevoflurane is more effective than propofol in ameliorating the inflammatory response in an animal model of acute respiratory distress syndrome." | 3.79 | Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study. ( Aguilar, G; Belda, FJ; Ferrando, C; Moreno, J; Piqueras, L; Soro, M, 2013) |
| "During CPB, isoflurane, in contrast to propofol, significantly contributes to a general increase in fluid shifts from the intravascular to the interstitial space with edema formation and a possible negative impact on postoperative organ function." | 3.79 | Isoflurane in contrast to propofol promotes fluid extravasation during cardiopulmonary bypass in pigs. ( Brekke, HK; Hammersborg, SM; Haugen, O; Husby, P; Kvalheim, VL; Lundemoen, S; Mongstad, A, 2013) |
| "To evaluate the effects of pretreatment, midazolam (M), propofol (P), ziprasidone (Z), and two combinations of [(midazolam plus propofol (MP); midazolam plus ziprasidone (MZ)] in mice models in the prevention of seizures, and death due to acute cocaine toxicity." | 3.79 | Assessment of propofol, midazolam and ziprasidone, or the combinations for the prevention of acute cocaine toxicity in a mouse model. ( Erdur, B; Ergin, A; Kortunay, S; Yuksel, A, 2013) |
| "Under both normovolemia and hypovolemia, glucose levels in rats anesthetized with sevoflurane were significantly higher than those in rats anesthetized with propofol, and insulin levels in rats anesthetized with sevoflurane were significantly lower than those in rats anesthetized with propofol." | 3.78 | The involvement of adenosine triphosphate-sensitive potassium channels in the different effects of sevoflurane and propofol on glucose metabolism in fed rats. ( Kawamura, G; Kitamura, T; Sato, K; Yamada, Y, 2012) |
| "This experimental study aimed to investigate the antioxidant effects of propofol anesthesia at induction doses in a rat skeletal muscle ischemia/reperfusion injury model." | 3.78 | Antioxidant effects of propofol on tourniquet-induced ischemia-reperfusion injury: an experimental study. ( Bostan, B; Erkorkmaz, U; Ozkan, F; Ozyurt, H; Senayli, Y, 2012) |
| " To test our hypothesis that anesthetics interact with the intrinsic parameters of ECT to differentially regulate its therapeutic efficacy, we investigated the effects of the anesthetic propofol and the stimulus intensities of ECT on behavior and hippocampal brain-derived neurotrophic factor (BDNF) in a rodent model of depression." | 3.78 | Propofol interacts with stimulus intensities of electroconvulsive shock to regulate behavior and hippocampal BDNF in a rat model of depression. ( Liu, Y; Luo, J; Min, S; Wei, K; Zhang, J, 2012) |
| "Propofol has been demonstrated to improve hepatic perfusion in a rabbit model; however, the effects of propofol on hepatic ischemia/reperfusion injury are unknown." | 3.78 | Propofol attenuates hepatic ischemia/reperfusion injury in an in vivo rabbit model. ( Luo, CZ; McCluskey, SA; Pang, QY; Ye, L; Zhu, T, 2012) |
| "Monitoring of exhaled pentane may be useful for evaluating the severity of hepatic ischemia-reperfusion injury and aid in predicting the outcome; propofol may improve the outcome in this situation." | 3.78 | Breath pentane as a potential biomarker for survival in hepatic ischemia and reperfusion injury--a pilot study. ( Gong, Y; He, Y; Li, E; Li, J; Li, P; Liu, D; Liu, S; Luo, A; Shi, J; Sun, B; Wang, C; Xu, G, 2012) |
| "These results show that the anesthetics propofol and 2,6-di-sec-butylphenol may be substituted in the para position with a 1-hydroxy-2,2,2-trifluoroethyl moiety and the resulting molecules have anticonvulsant activity in the 6 Hz model while exhibiting less toxicity (ataxia) than the parent 2,6-dialkylphenols." | 3.77 | The anticonvulsant effects of propofol and a propofol analog, 2,6-diisopropyl-4-(1-hydroxy-2,2,2-trifluoroethyl)phenol, in a 6 Hz partial seizure model. ( Baker, MT, 2011) |
| " We investigated the effect of propofol on HIF-1α expression and acute lung injury in LPS-treated mice." | 3.77 | Propofol inhibits lipopolysaccharide-induced lung epithelial cell injury by reducing hypoxia-inducible factor-1alpha expression. ( Cho, W; Chu, CC; Hsing, CH; Lin, MC; So, EC; Wang, JJ; Yeh, CH, 2011) |
| "To explore the effects of propofol on the outcomes of rats with sepsis." | 3.77 | Effects of propofol on the outcomes of rats with sepsis. ( Bao, HG; Li, S, 2011) |
| "Sixty Sprague-Dawley rats were randomly divided into 5 groups (n = 12 rats per group): control group, depression group, propofol group, ECT group, and propofol + ECT group." | 3.76 | Effects of electroconvulsive therapy and propofol on spatial memory and glutamatergic system in hippocampus of depressed rats. ( Cao, J; Dong, J; Li, P; Li, Y; Min, S; Wei, K, 2010) |
| " Research has shown that propofol, which is an intravenous anesthetic agent, exhibits neuroprotective effects against cerebral ischemia-reperfusion injury, although the neuroprotective mechanism is still unclear." | 3.76 | The effects of propofol on hippocampal caspase-3 and Bcl-2 expression following forebrain ischemia-reperfusion in rats. ( Han, B; Li, J; Ma, X; Qi, S, 2010) |
| " Hypoxemia episodes were induced by apnea alone or by apnea combined with a reduction in LV and C(RS)." | 3.75 | Targeted minute ventilation and tidal volume in an animal model of acute changes in lung mechanics and episodes of hypoxemia. ( Bancalari, E; Claure, N; D'Ugard, C; Hehre, D; Peng, J; Suguihara, C, 2009) |
| "To observe the influence of propofol on corticosteroid, and cytokines in rats after hemorrhagic shock and resuscitation, as well as its protective effects on vital organs." | 3.75 | [The influences of propofol on corticosteroid and immunity of rats after hemorrhagic shock and resuscitation]. ( Cao, SH; Ji, X, 2009) |
| " Two animal models of TLE--amygdala kindling and pilocarpine-induced status epilepticus (Pilo-SE)--were tested." | 3.75 | Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. ( Leung, LS; Long, JJ; Luo, T; McMurran, TJ; Shen, B; Stewart, L, 2009) |
| "To investigate the effect of propofol intra-aortic and intravenous infusion on the concentration of propofol for an ischemia-reperfusion spinal cord injury in rabbits." | 3.74 | [Comparison of propofol concentration in the spinal cord between intra-aortic and intravenous infusion]. ( Liao, Z; Lin, Y; Zhang, J; Zhang, L, 2008) |
| " Although its mechanism of smooth muscle relaxation is unknown, propofol has been associated with less bronchoconstriction during anaesthetic induction." | 3.74 | Investigation of the relaxant effects of propofol on ovalbumin-induced asthma in guinea pigs. ( Bagcivan, I; Cevit, O; Gursoy, S; Kaya, T; Mimaroglu, C; Yildirim, MK; Yildirim, S, 2007) |
| "We previously found that propofol attenuated the mortality rate and inflammatory responses during endotoxemia in rats; however, whether propofol retains its antiinflammatory effects during hypothermia has not been determined." | 3.74 | The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia. ( Kanakura, H; Taniguchi, T, 2007) |
| "We have previously demonstrated, in the isolated rat heart, that propofol attenuates hydrogen peroxide-induced damage and ischaemia-reperfusion injury, and that the beneficial effect of propofol is correlated with reduction of the lipid peroxidation." | 3.74 | Propofol attenuates ischaemia-reperfusion injury in the rat heart in vivo. ( Kobayashi, I; Kokita, N; Namiki, A, 2008) |
| "To study the therapeutic effect and its mechanisms of propofol on gastric mucosal injury after hemorrhagic shock with reperfusion in rabbits." | 3.74 | [Effect of propofol on gastric mucosal injury after hemorrhagic shock and reperfusion in rabbits]. ( Li, HY; Lü, YX; Wang, LL; Zhang, LF, 2008) |
| "We conclude that the severity of remote lung injury was not different between sevoflurane and propofol anaesthesia in this porcine model of severe lower-body ischaemia and reperfusion injury." | 3.74 | Lung injury following thoracic aortic occlusion: comparison of sevoflurane and propofol anaesthesia. ( Annecke, T; Bittmann, I; Conzen, PF; Hilberath, JM; Kahr, S; Kemming, GI; Krombach, F; Kubitz, JC; Langer, K; Rehm, M, 2008) |
| "To explore whether propofol plays a protective role in kidney injury during acute respiratory distress syndrome (ARDS) by affecting the expression of Gq/11 protein." | 3.73 | [Influence of propofol on Gq/11 protein in kidney during acute respiratory distress syndrome]. ( Abasi, K; Jialili, A; Li, XJ; Zhang, L, 2006) |
| "Although TIVA is less prone than isoflurane anaesthesia to primary cardiovascular depression leading to asphyxia, TIVA is associated with reduced effectiveness of CPR in which resuscitation because of asphyxic haemodynamic depression occurs." | 3.72 | Comparison of isoflurane and propofol-fentanyl anaesthesia in a swine model of asphyxia. ( Kazama, T; Kurita, T; Morita, K; Sato, S, 2003) |
| "Propofol in this model was more arrhythmogenic than thiopental, as manifested by a longer duration of induced arrhythmias, particularly AFI." | 3.72 | Comparative effects of thiopental and propofol on atrial vulnerability: electrophysiological study in a porcine model including acute alcoholic intoxication. ( Almendral, J; Anadón, MJ; González, P; Navia, J; Zaballos, M, 2004) |
| "Intrathecal administration of propofol had analgesic effects on inflammation-induced acute and facilitated pain but not on thermally-induced acute pain." | 3.72 | Intrathecal propofol has analgesic effects on inflammation-induced pain in rats. ( Hanaoka, K; Matsukawa, T; Nishiyama, T, 2004) |
| "To compare the effects of pentobarbital and propofol on the outcome of focal cerebral ischemia model, and to evaluate the availability of propofol in setting the focal cerebral ischemia." | 3.72 | [Comparison of pentobarbital and propofol on the outcome of focal cerebral ischemia model in rats]. ( Kang, QY; Li, J; Liu, Y; Zhang, PB; Zhao, JJ, 2004) |
| "We investigated the effects of selective and non-selective endothelin (ET) antagonists on warm ischemia-reperfusion injury of the early phase in the murine liver under propofol anesthesia." | 3.70 | [Effects of endothelin antagonists on isolated perfused murine livers in the early phase of warm ischemia-reperfusion injury under propofol anesthesia]. ( Karasawa, F; Sato, T; Tanaka, K, 1999) |
| "It has been suggested that propofol has the protective effect on cerebral ischemia-reperfusion injury." | 3.70 | Effectiveness of propofol pretreatment on the extent of deranged cerebral mitochondrial oxidative enzyme system after incomplete forebrain ischemia/reperfusion in rats. ( Chung, C; Lee, Y; Oh, YS, 2000) |
| " Propofol was used for surgical anesthesia because recovery in normal animals from an intravenous infusion was found to be nearly complete within 2 h of cessation and absolutely complete by 4 h." | 3.68 | Early assessment of neurologic deficits in the fluid percussion model of brain injury. ( Einhaus, SL; Hilton, DL; Meric, AL; Park, MR; Robertson, JT; Schweitzer, JB; White, RP, 1993) |
| "We have examined the anticonvulsant properties of propofol in high doses in two experimental models of status epilepticus: generalized pentylenetetrazol (PTZ)-induced seizures and partial, cortically applied penicillin G-induced seizures." | 3.68 | Propofol anticonvulsant activity in experimental epileptic status. ( Caria, MA; De Riu, PL; Mameli, O; Melis, F; Mulas, M; Petruzzi, V; Testa, C, 1992) |
| "Propofol has yet not arrived on the local black markets." | 2.47 | [Assessment of the addictive risk of propofol]. ( Bonnet, U, 2011) |
| "Propofol functions as a tumor-inhibitor drug by regulating microRNAs (miRNAs)." | 1.91 | Propofol decreases cisplatin resistance of non-small cell lung cancer by inducing GPX4-mediated ferroptosis through the miR-744-5p/miR-615-3p axis. ( Han, B; Liang, L; Liu, Y; Zhang, Q, 2023) |
| "Propofol is an anesthetic agent with neuroprotective property." | 1.72 | Propofol via Antioxidant Property Attenuated Hypoxia-Mediated Mitochondrial Dynamic Imbalance and Malfunction in Primary Rat Hippocampal Neurons. ( Chen, J; Cui, W; Han, J; Tao, W, 2022) |
| "Propofol is a known intravenous hypnotic drug used for induction and maintenance of sedation and general anesthesia." | 1.62 | Propofol Suppresses Microglia Inflammation by Targeting TGM2/NF- ( Hou, Y; Qi, S; Xiao, X; Yu, W, 2021) |
| "Propofol acts as an intravenous anesthetic cure which is widely used as a therapy for the craniocerebral injury that comprised surgical anesthesia as well as the sedation done in the intensive care units." | 1.62 | Propofol Alleviates Neuropathic Pain Induced by Chronic Contractile Injury by Regulating the Spinal glun2b-p38mapkepac1 Pathway. ( Li, W; Qin, C; Yan, J; Yang, Y; You, L; Zhao, Q, 2021) |
| "Propofol- or vehicle-treated tumor cells are also injected to the mice." | 1.62 | Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABA ( Cheng, C; Lanuti, M; Liu, Q; Liu, R; Shen, Y; Sheng, Z; Wang, P; Xie, Z; Zheng, H, 2021) |
| "Propofol is an intravenous anesthetic that is commonly used during intravascular embolectomy following acute ischemic stroke." | 1.56 | Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke. ( Cui, V; Tian, D; Wang, H; Wang, Y; Wei, C; Wu, A; Yue, Y; Zhu, Y, 2020) |
| "Propofol treatment improved VILI, alleviated pulmonary inflammation induced by mechanical ventilation." | 1.56 | Propofol alleviates ventilator-induced lung injury through regulating the Nrf2/NLRP3 signaling pathway. ( Chen, G; Li, W; Ruan, H; Wang, J; Wang, Z; Xia, B; Zhang, M, 2020) |
| "Propofol was effective, exhibiting high efficacy and potency for terminating seizure activity quickly in pediatric and adult animals, suggesting it may be an effective anticonvulsant for NA-induced seizures in pediatric populations." | 1.56 | Evaluation of fosphenytoin, levetiracetam, and propofol as treatments for nerve agent-induced seizures in pediatric and adult rats. ( Ardinger, CE; Berger, KE; Dunn, EN; Haines, KM; Jackson Piercy, CE; Lee-Stubbs, RB; Matson, LM; McCarren, HS; McDonough, JH; Miller-Smith, SM; Whitten, KA, 2020) |
| "Autism is a challenging neurodevelopmental disorder." | 1.51 | Dexmedetomidine and propofol sedation requirements in an autistic rat model. ( Elgendy, H; Elmorsy, SA; Rashed, LA; Soliman, GF, 2019) |
| "Propofol was added intraperitoneally to the mice from 7th day of insulin/saline treatment, and general anesthesia was induced and maintained for 2 hours/day for 5 consecutive days." | 1.51 | Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice. ( Huang, F; Ke, D; Li, X; Liang, Z; Liu, R; Run, X; Wang, JZ; Wang, Q; Wang, X; Wei, Z; Zeng, K; Zhang, B, 2019) |
| "Mechanical allodynia induced by plantar incision peaked at 1 hr and lasted for 3 days after incision." | 1.51 | Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain. ( Cheung, CW; Gu, P; Li, Q; Qiu, Q; Sun, L; Wang, XM; Wong, SS, 2019) |
| "Propofol treatment alleviated intestinal and lung morphological changes which were observed in II/R group，Moreover, wet/dry weight ratio, the MDA level, MPO activity and expression of caspase-3 were significantly decreased whereas the SOD activity and p-Akt expression were significantly increased." | 1.51 | The role of PI3K/Akt signal pathway in the protective effects of propofol on intestinal and lung injury induced by intestinal ischemia/reperfusion1. ( Cui, S; Ding, H; He, X; Jing, G; Li, Q; Xia, Z, 2019) |
| " Intralipid (10%, 10 mL/kg) for vehicle control and different dosage of propofol for three treatment groups (50, 100 and 200 mg/kg) were administered intraperitoneally." | 1.48 | PKA-CREB-BDNF signaling pathway mediates propofol-induced long-term learning and memory impairment in hippocampus of rats. ( Chen, J; Jiang, Y; Li, L; Pan, S; Qin, Y; Wei, Y; Xie, Y; Zhong, Y, 2018) |
| "Propofol was injected for anesthesia (n = 22)." | 1.48 | The recovery from transient cognitive dysfunction induced by propofol was associated with enhanced autophagic flux in normal healthy adult mice. ( Baik, HJ; Cho, S; Han, JI; Jung, YJ; Lee, GY; Lee, KE; Suh, EC, 2018) |
| "Pre-treatment with propofol significantly increased the CoBF and DPOAE amplitudes, decreased 8-iso-PGF2α and the loss of OHCs." | 1.46 | Protective effect of propofol on noise-induced hearing loss. ( Duan, N; Jing, GX; Wang, Q; Wen, J; Xiao, Y, 2017) |
| "Propofol treatment could elicit a robust neuroprotective response, resulting in significant neurological function improvement for TBI rats, which was independent with intralipid." | 1.43 | Propofol administration improves neurological function associated with inhibition of pro-inflammatory cytokines in adult rats after traumatic brain injury. ( Chen, MR; Liu, F; Liu, J; Wang, TH; Wang, TY; Zou, Y; Zuo, YX, 2016) |
| " The propofol self-administration model was established by a fixed ratio 1 (FR1) schedule of reinforced dosing over successive 14days in rats." | 1.43 | Glucocorticoid receptor mediated the propofol self-administration by dopamine D1 receptor in nucleus accumbens. ( Chen, Z; Dong, Z; Ge, RS; Lian, Q; Liang, Y; Lin, W; Wang, B; Wang, S; Wu, B; Zhang, G, 2016) |
| "Propofol (30 mg/kg) was intraperiotoneally administered to 7‑day‑old Sprague Dawley rats (n=75) three times each day at 90 min intervals for seven consecutive days with or without Dex (75 µg/kg) treatment 20 min prior to propofol injection." | 1.43 | Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats. ( Guo, X; Han, B; Mao, M; Wang, J; Wang, Y; Wu, C; Xu, F, 2016) |
| "When propofol was applied for 4-8 h after kainate washout, strong neuroprotection was observed in all spinal areas, including attenuation of motoneuron loss." | 1.43 | Neuroprotective effect of propofol against excitotoxic injury to locomotor networks of the rat spinal cord in vitro. ( Flores Gutiérrez, J; Kaur, J; Nistri, A, 2016) |
| "Propofol is an intravenous sedative-hypnotic agent that is commonly used to induce and maintain general anaesthesia." | 1.43 | Effects of Propofol on Oxidative Stress Parameters in Selected Parts of the Brain in a Rat Model of Parkinson Disease. ( Birkner, E; Chwalińska, E; Hudziec, E; Nowak, P; Prudel, B; Romuk, E; Skowron, M; Szczurek, W, 2016) |
| "Pretreatment with propofol significantly ameliorated renal pathology and abrogated the increase of the Cr and BUN concentrations, O2•‑ and ·OH activities, and MDA levels induced by OLAT." | 1.42 | Propofol pretreatment attenuates remote kidney injury induced by orthotopic liver autotransplantation, which is correlated with the activation of Nrf2 in rats. ( Chi, X; Ge, M; Hei, Z; Luo, C; Luo, G; Yao, W; Yuan, D; Zhou, S, 2015) |
| " Clinical data imply a correlation between cumulative propofol dosage and diaphragm dysfunction, whereas laboratory investigations have revealed that propofol has some antioxidant properties." | 1.40 | Sedation using propofol induces similar diaphragm dysfunction and atrophy during spontaneous breathing and mechanical ventilation in rats. ( Bergs, I; Bleilevens, C; Bruells, CS; Cielen, N; Gayan-Ramirez, G; Maes, K; Rossaint, R; Thomas, D; Weis, J, 2014) |
| "Propofol was administrated to the WT and AD Tg mice once a week for 8 or 12 weeks, respectively." | 1.40 | Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice. ( Dong, Y; Shao, H; Xia, W; Xie, Z; Yu, B; Zhang, Y, 2014) |
| "Propofol is a short-acting, intravenous general anesthetic that is widely used in clinical practice for short procedures; however, it causes depressed cognitive function for several hours thereafter." | 1.40 | (R)-alpha-methylhistamine suppresses inhibitory neurotransmission in hippocampal CA1 pyramidal neurons counteracting propofol-induced amnesia in rats. ( Cheng, LZ; Li, WW; Raya, AD; Shi, XY; Tian, ML; Wang, Y; Zhang, H; Zou, Z, 2014) |
| "A medically induced coma is an anesthetic state of profound brain inactivation created to treat status epilepticus and to provide cerebral protection after traumatic brain injuries." | 1.39 | Real-time closed-loop control in a rodent model of medically induced coma using burst suppression. ( Brown, EN; Chemali, JJ; Ching, S; Kenny, JD; Liberman, MY; Purdon, PL; Solt, K; Westover, MB, 2013) |
| "Propofol treatment reduced infarct volume and improved the neurological functions." | 1.39 | Propofol protects against focal cerebral ischemia via inhibition of microglia-mediated proinflammatory cytokines in a rat model of experimental stroke. ( Liu, F; Tan, Y; Tang, X; Wu, X; Yang, Z; Zhou, R, 2013) |
| "Propofol is an intravenous anesthetic widely used for sedation and general anesthesia." | 1.37 | Possible role of propofol's cyclooxygenase-inhibiting property in alleviating dopaminergic neuronal loss in the substantia nigra in an MPTP-induced murine model of Parkinson's disease. ( Inada, T; Kubo, K; Shingu, K, 2011) |
| "Propofol is a drug used in anesthesia that has unique antioxidant qualities that may be beneficial." | 1.36 | Apoptosis: understanding programmed cell death for the CRNA. ( Bennetts, PS; Pierce, JD, 2010) |
| "Pretreatment with propofol significantly decreased writhing responses induced by visceral pain, suppressed the visceral pain-induced aspartate and glutamate release, and reversed the decreased release of γ-amino butyric acid in the cerebrospinal fluid." | 1.36 | Effects of anesthetic propofol on release of amino acids from the spinal cord during visceral pain. ( Fang, L; Liu, Y; Mu, X; Wang, Y; Wu, A; Wu, J; Yue, Y; Zhang, Y, 2010) |
| "Propofol has inhibited the hepatic NF-kappaB activation and the pro-inflammatory cytokine response during polymicrobial sepsis in rats." | 1.35 | Effects of propofol on pro-inflammatory cytokines and nuclear factor kappaB during polymicrobial sepsis in rats. ( Li, JG; Liang, H; Song, XM; Wang, CY; Wang, YL; Zhang, ZZ; Zhou, Q, 2009) |
| "Remifentanil has been implicated as causing intraoperative bradyarrhythmias, but little information is available regarding its cardiac electrophysiological effects." | 1.35 | Cardiac electrophysiological effects of remifentanil: study in a closed-chest porcine model. ( Almendral, J; Anadón, MJ; Atienza, F; Jimeno, C; Navia, J; Patiño, D; Valdes, E; Zaballos, M, 2009) |
| "Rats underwent 2 h of middle cerebral artery occlusion (MCAO) followed by 22 h of reperfusion were randomly divided into nine groups (n=15 each): sham-operated group, MCAO group, propofol 10, 20 and 35 mg x kg(-1) x h(-1) group (propofol 10, 20, 35 mg x kg(-1) x h(-1) infused at the onset of reperfusion for 30 min), wortmannin group (wortmannin 0." | 1.35 | The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats. ( Wang, GL; Wang, HY; Wang, Y; Yu, YH, 2009) |
| "Propofol has been demonstrated to ameliorate cerebral ischemic injury and attenuate changes in multiple links of molecular reaction included in the paths to apoptosis." | 1.35 | Effect of propofol on pathologic time-course and apoptosis after cerebral ischemia-reperfusion injury. ( Chen, L; Jiang, H; Xue, Z, 2008) |
| "Treatment with propofol abrogated or reversed the oleic acid-induced changes." | 1.35 | Protective effects of propofol on acute lung injury induced by oleic acid in conscious rats. ( Chen, HI; Hsieh, NK; Kao, SJ; Su, CF, 2008) |
| "ICAM-1 plays an important role in lung injury after intestinal I/R." | 1.33 | [Propofol reduces intercellular adhesion molecular-1 expression in lung injury following intestinal ischemia/reperfusion in rats]. ( Hu, XM; Lu, Y; Yao, SL, 2005) |
| "Rats treated with isoflurane had the best cognitive recovery (p < 0." | 1.33 | Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. ( Alexander, H; Clark, RS; Dixon, CE; Jenkins, L; Kochanek, PM; Statler, KD; Vagni, V, 2006) |
| "Naloxone did not cause changes in ejection fraction or mean pulmonary artery pressure in hypoxic and hypercarbic conditions." | 1.33 | Cardiovascular changes after naloxone administration in propofol-sedated piglets during opioid overdose. ( Aittomäki, JV; Boyd, JJ; Kyttä, JV; Randell, TT; Rosenberg, PH; Seppälä, TA, 2006) |
| "Hepatic encephalopathy is a neurologic syndrome secondary to liver failure that causes cognitive and motor abnormalities." | 1.33 | Functional abnormalities of the motor tract in the rat after portocaval anastomosis and after carbon tetrachloride induction of cirrhosis. ( Bartolí, R; Chatauret, N; Córdoba, J; Odena, G; Oria, M; Planas, R; Raguer, N, 2006) |
| "propofol was not significantly different between ethanol-treated and control rats." | 1.32 | Chronic ethanol consumption does not affect action of propofol on rat hippocampal acetylcholine release in vivo. ( Andoh, T; Inagawa, G; Kikuchi, T; Koyama, Y; Nishihama, M; Sato, K; Shioda, M; Yamada, Y, 2004) |
| " Etoposide phosphate in combination with any other agent was observed to be highly neurotoxic if both agents were administered after BBBD." | 1.31 | Unexpected neurotoxicity of etoposide phosphate administered in combination with other chemotherapeutic agents after blood-brain barrier modification to enhance delivery, using propofol for general anesthesia, in a rat model. ( Fortin, D; McCormick, CI; Neuwelt, EA; Nixon, R; Remsen, LG, 2000) |
| "Status epilepticus is commonly refractory to first-line therapy, and thus better treatments are needed." | 1.31 | Propofol in subanesthetic doses terminates status epilepticus in a rodent model. ( Holtkamp, M; Tong, X; Walker, MC, 2001) |
| "In the other 15 cats, cytotoxic brain edema (CBE) was created by an acute reduction in blood osmolality." | 1.30 | The effects of intravenous anesthetics on intracranial pressure and cerebral perfusion pressure in two feline models of brain edema. ( Nimkoff, L; Quinn, C; Sagy, M; Silver, P, 1997) |
| "Propofol is a cardiac depressant with minimal diastolic effects in the adult myocardium." | 1.30 | Left ventricular systolic and diastolic function is unaltered during propofol infusion in newborn swine. ( Graham, MR; Mutch, WA; Thiessen, DB, 1998) |
| "Pentobarbital pretreatment failed to suppress FLI." | 1.30 | Pre- versus postinjury effects of intravenous GABAergic anesthetics on formalin-induced Fos immunoreactivity in the rat spinal cord. ( Coderre, TJ; Gilron, I; Quirion, R, 1999) |
| "Propofol did not produce direct effects on the electrophysiological or electrocardiographical variables at any infusion rates." | 1.30 | Propofol does not affect the canine cardiac conduction system under autonomic blockade. ( Akazawa, S; Ikeno, S; Inoue, S; Ishii, R; Nakaigawa, Y; Satoh, M; Shimizu, R, 1999) |
| " However, the dose-response relationship, reproducibility and effect of anesthetic agents on induction are not well understood." | 1.30 | Induction of atrial fibrillation and flutter in dogs using methacholine. ( Ross, DL; Thomas, SP, 1999) |
| " Morphine, pethidine and fentanyl, which showed a biphasic dose-response relationship with respect to seizure modulation, abolished the anticonvulsant activity of propofol to exhibit their own intrinsic activity in proconvulsant doses." | 1.29 | Interactions between opioid drugs and propofol in laboratory models of seizures. ( Ahmad, I; Pleuvry, BJ, 1995) |
| "Forebrain ischemia was produced by bilaterally occluding the common carotid arteries for 10 minutes; then the blood supply to the brain was restored." | 1.29 | Effect of 2,6-diisopropylphenol on the delayed hippocampal cell loss following transient forebrain ischemia in the gerbil. ( Arcadi, FA; Costa, G; De Luca, R; Rapisarda, A; Trimarchi, GR, 1996) |
| "Anaesthetic techniques for malignant hyperthermia susceptible (MHS) patients should include drugs which do not trigger MH and provide stress free conditions." | 1.28 | Effect of propofol on the malignant hyperthermia susceptible pig model. ( Adnet, P; Becq, MC; Krivosic-Horber, R; Reyfort, H, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.46) | 18.7374 |
| 1990's | 16 (7.34) | 18.2507 |
| 2000's | 51 (23.39) | 29.6817 |
| 2010's | 113 (51.83) | 24.3611 |
| 2020's | 37 (16.97) | 2.80 |
| Authors | Studies |
|---|---|
| Mishra, RK | 1 |
| Baker, MT | 2 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 5 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Hou, Y | 2 |
| Xiao, X | 1 |
| Yu, W | 1 |
| Qi, S | 2 |
| Shen, M | 1 |
| Lian, N | 1 |
| Song, C | 1 |
| Qin, C | 2 |
| Yu, Y | 2 |
| Yan, J | 1 |
| Zhao, Q | 1 |
| You, L | 1 |
| Yang, Y | 3 |
| Sousa, GC | 1 |
| Fernandes, MV | 1 |
| Cruz, FF | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Intranasal Insulin Improves Postoperative Neurocognitive Disorders in Elderly Patients: a Multicenter, Randomized, Double-blind, Placebo-controlled Study[NCT05613491] | 438 participants (Anticipated) | Interventional | 2022-11-07 | Recruiting | |||
| AnaConDa-therapy in COVID-19 Patients[NCT05586126] | 42 participants (Actual) | Observational | 2020-10-01 | Terminated (stopped due to Concerns about possible association between drug and increased ICU mortality) | |||
| Volatile Anesthetic Pharmacokinetics During Extracorporeal Membrane[NCT05680545] | 10 participants (Anticipated) | Interventional | 2024-07-01 | Not yet recruiting | |||
| A Randomized Pilot Clinical Trial of the Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction of Sevoflurane in Patient's Whit ARDS Secondary to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2)[NCT04998253] | Early Phase 1 | 24 participants (Actual) | Interventional | 2020-10-01 | Completed | ||
| Sevoflurane Sedation: A Potentially Promising Immunomodulation in Patients With Septic Shock[NCT03643367] | Phase 2 | 153 participants (Anticipated) | Interventional | 2025-01-31 | Not yet recruiting | ||
| "Hemodynamic Stability During Induction of General Anesthesia With Propofol and Remifentanil: A Randomized, Controlled, Double-blind Study Comparing Medium and Low Remifentanil Doses."[NCT03861377] | Phase 4 | 99 participants (Actual) | Interventional | 2020-06-09 | Completed | ||
| Investigation of Changes in the Levels of Exhaled NO and Eosinophil Blood Count in Patients Undergoing Thyroidectomy by Two Different Methods of General Anesthesia Maintenance[NCT02065635] | 60 participants (Actual) | Interventional | 2014-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for propofol and Disease Models, Animal
| Article | Year |
|---|---|
Effects of propofol on ischemia-reperfusion and traumatic brain injury.
Topics: Anesthesia; Anesthetics; Animals; Apoptosis; Astrocytes; Brain; Brain Injuries, Traumatic; Disease M | 2020 |
The Relationship Between Sedatives, Sedative Strategy, and Healthcare-Associated Infection: A Systematic Review.
Topics: Animals; Benzodiazepines; Clinical Trials as Topic; Critical Care; Cross Infection; Disease Models, | 2016 |
[Assessment of the addictive risk of propofol].
Topics: Administration, Oral; Anesthetics, Intravenous; Animals; Disease Models, Animal; Electroconvulsive T | 2011 |
1 trial available for propofol and Disease Models, Animal
| Article | Year |
|---|---|
Connexin 32 deficiency protects the liver against ischemia/reperfusion injury.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Connexins; Disease Models, Animal; Gap Junction b | 2020 |
214 other studies available for propofol and Disease Models, Animal
| Article | Year |
|---|---|
Seizure prevention by the naturally occurring phenols, carvacrol and thymol in a partial seizure-psychomotor model.
Topics: Animals; Anticonvulsants; Cymenes; Disease Models, Animal; Monoterpenes; Phenols; Psychomotor Perfor | 2014 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Propofol Suppresses Microglia Inflammation by Targeting TGM2/NF-
Topics: Animals; Animals, Newborn; Disease Models, Animal; Gene Knockdown Techniques; Guanosine Triphosphate | 2021 |
Different Anesthetic Drugs Mediate Changes in Neuroplasticity During Cognitive Impairment in Sleep-Deprived Rats via Different Factors.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Cognitive Dysfunction; Disease Models, A | 2021 |
Propofol Alleviates Neuropathic Pain Induced by Chronic Contractile Injury by Regulating the Spinal glun2b-p38mapkepac1 Pathway.
Topics: Anesthetics, Intravenous; Animals; Computational Biology; Disease Models, Animal; Ganglia, Spinal; G | 2021 |
Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke.
Topics: Animals; Brain; Brain Ischemia; Dexmedetomidine; Disease Models, Animal; Endothelial Cells; Hypnotic | 2021 |
Propofol via Antioxidant Property Attenuated Hypoxia-Mediated Mitochondrial Dynamic Imbalance and Malfunction in Primary Rat Hippocampal Neurons.
Topics: Animals; Antioxidants; Cell Hypoxia; Disease Models, Animal; Hippocampus; Mitochondrial Dynamics; Ne | 2022 |
Assessing ultrasonographic optic nerve sheath diameter in animal model with anesthesia regimens.
Topics: Anesthesia; Animals; Disease Models, Animal; Ketamine; Optic Nerve; Propofol; Swine; Thiopental; Xyl | 2022 |
Propofol Suppresses Glioma Tumorigenesis by Regulating circ_0047688/miR-516b-5p/IFI30 Axis.
Topics: Animals; Apoptosis; Carcinogenesis; Cell Proliferation; Disease Models, Animal; Glioma; Humans; Mice | 2023 |
Immunomodulatory roles of propofol and sevoflurane in murine models of breast cancer.
Topics: Animals; Breast Neoplasms; Disease Models, Animal; Female; Humans; Methyl Ethers; Mice; Propofol; Se | 2023 |
Post-cardiac arrest Sedation Promotes Electroencephalographic Slow-wave Activity and Improves Survival in a Mouse Model of Cardiac Arrest.
Topics: Animals; Cardiopulmonary Resuscitation; Dexmedetomidine; Disease Models, Animal; Electroencephalogra | 2022 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol Inhibits Ferroptotic Cell Death Through the Nrf2/Gpx4 Signaling Pathway in the Mouse Model of Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Antioxidants; Cell Death; Disease Models, Animal; Lipid Peroxides; Mice; NF-E2-Related Fact | 2023 |
Propofol decreases cisplatin resistance of non-small cell lung cancer by inducing GPX4-mediated ferroptosis through the miR-744-5p/miR-615-3p axis.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Disease Mo | 2023 |
Propofol decreases cisplatin resistance of non-small cell lung cancer by inducing GPX4-mediated ferroptosis through the miR-744-5p/miR-615-3p axis.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Disease Mo | 2023 |
Propofol decreases cisplatin resistance of non-small cell lung cancer by inducing GPX4-mediated ferroptosis through the miR-744-5p/miR-615-3p axis.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Disease Mo | 2023 |
Propofol decreases cisplatin resistance of non-small cell lung cancer by inducing GPX4-mediated ferroptosis through the miR-744-5p/miR-615-3p axis.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Disease Mo | 2023 |
Propofol decreases cisplatin resistance of non-small cell lung cancer by inducing GPX4-mediated ferroptosis through the miR-744-5p/miR-615-3p axis.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Disease Mo | 2023 |
Propofol decreases cisplatin resistance of non-small cell lung cancer by inducing GPX4-mediated ferroptosis through the miR-744-5p/miR-615-3p axis.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Disease Mo | 2023 |
Propofol decreases cisplatin resistance of non-small cell lung cancer by inducing GPX4-mediated ferroptosis through the miR-744-5p/miR-615-3p axis.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Disease Mo | 2023 |
Propofol decreases cisplatin resistance of non-small cell lung cancer by inducing GPX4-mediated ferroptosis through the miR-744-5p/miR-615-3p axis.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Disease Mo | 2023 |
Propofol decreases cisplatin resistance of non-small cell lung cancer by inducing GPX4-mediated ferroptosis through the miR-744-5p/miR-615-3p axis.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Disease Mo | 2023 |
Fropofol prevents disease progression in mice with hypertrophic cardiomyopathy.
Topics: Animals; Calcium Signaling; Cardiac Myosins; Cardiomyopathy, Hypertrophic; Disease Models, Animal; D | 2020 |
Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke.
Topics: alpha-Synuclein; Animals; Behavior, Animal; Brain Infarction; Brain Ischemia; Disease Models, Animal | 2020 |
PRR34-AS1 overexpression promotes protection of propofol pretreatment against ischemia/reperfusion injury in a mouse model after total knee arthroplasty via blockade of the JAK1-dependent JAK-STAT signaling pathway.
Topics: Animals; Apoptosis; Arthroplasty, Replacement, Knee; Cell Proliferation; Disease Models, Animal; Gen | 2020 |
Propofol Reduces Inflammatory Brain Injury after Subarachnoid Hemorrhage: Involvement of PI3K/Akt Pathway.
Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Edema; Cyclooxygenase 2; Disease Models, Animal; Enc | 2019 |
Propofol attenuates inflammatory response and apoptosis to protect d-galactosamine/lipopolysaccharide induced acute liver injury via regulating TLR4/NF-κB/NLRP3 pathway.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Chemical and Drug Induced Liver Injury; Cytokines; Dis | 2019 |
Effect of propofol on myocardial ischemia-reperfusion injury through MAPK/ERK pathway.
Topics: Administration, Oral; Animals; Cardiotonic Agents; Cells, Cultured; Disease Models, Animal; Dose-Res | 2019 |
The Molecular Mechanisms Associated with the Effects of Propofol in a Rat Model of Pain Due to Inflammation Following Injection with Complete Freund's Adjuvant.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Freund's Adjuvant; Inflammasomes; Inflammation; I | 2019 |
Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models.
Topics: Anesthetics, General; Animals; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; H | 2020 |
Propofol post-conditioning lessens renal ischemia/reperfusion-induced acute lung injury associated with autophagy and apoptosis through MAPK signals in rats.
Topics: Acute Kidney Injury; Acute Lung Injury; Animals; Apoptosis; Autophagy; Disease Models, Animal; Human | 2020 |
Propofol alleviates ventilator-induced lung injury through regulating the Nrf2/NLRP3 signaling pathway.
Topics: Animals; Disease Models, Animal; Humans; Inflammation; Lung; Mice; Mitochondria; NF-E2-Related Facto | 2020 |
Propofol inhibited apoptosis of hippocampal neurons in status epilepticus through miR-15a-5p/NR2B/ERK1/2 pathway.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Down-Regulati | 2020 |
Evaluation of fosphenytoin, levetiracetam, and propofol as treatments for nerve agent-induced seizures in pediatric and adult rats.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Disease Models, Animal; Female; Levetiracetam; Male; O | 2020 |
Propofol improves intestinal ischemia-reperfusion injury in rats through NF-κB pathway.
Topics: Animals; Apoptosis; Cytokines; Disease Models, Animal; Female; Hypnotics and Sedatives; Injections, | 2020 |
Sevoflurane as opposed to propofol anesthesia preserves mitochondrial function and alleviates myocardial ischemia/reperfusion injury.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Disease Models, Animal; Electron Transpo | 2020 |
Sevoflurane induces neuronal activation and behavioral hyperactivity in young mice.
Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Behavior, Animal; Disease Models, Animal; | 2020 |
Propofol Improved Glucose Tolerance Associated with Increased FGF-21 and GLP-1 Production in Male Sprague-Dawley Rats.
Topics: Animals; Blood Glucose; Disease Models, Animal; Fibroblast Growth Factors; Glucagon-Like Peptide 1; | 2020 |
Propofol abolishes torsade de pointes in different models of acquired long QT syndrome.
Topics: Action Potentials; Animals; Disease Models, Animal; Electrocardiography; Erythromycin; Heart; Heart | 2020 |
Propofol alleviates hypoxic neuronal injury by inhibiting high levels of mitochondrial fusion and fission.
Topics: Animals; Cell Survival; Cells, Cultured; Disease Models, Animal; Hypnotics and Sedatives; Hypoxia; M | 2020 |
Hypermethylation of EFEMP1 in the Hippocampus May Be Related to the Deficit in Spatial Memory of Rat Neonates Triggered by Repeated Administration of Propofol.
Topics: Animals; Animals, Newborn; Body Weight; CpG Islands; Disease Models, Animal; DNA Methylation; Epigen | 2020 |
[Establishing Evidence for Use of Appropriate Medicines in the Operating Room].
Topics: Animals; Anti-Infective Agents, Local; Cell Line; Disease Models, Animal; Dose-Response Relationship | 2021 |
Elevated preoptic brain activity in zebrafish glial glycine transporter mutants is linked to lethargy-like behaviors and delayed emergence from anesthesia.
Topics: Aminobenzoates; Anesthesia, General; Anesthetics; Animals; Animals, Genetically Modified; Craniotomy | 2021 |
Propofol alleviates intestinal ischemia/reperfusion injury in rats through p38 MAPK/NF-κB signaling pathway.
Topics: Animals; Disease Models, Animal; Intestines; Male; Myocardial Reperfusion Injury; NF-kappa B; p38 Mi | 2021 |
HOTAIR/miR-17-5p Axis is Involved in the Propofol-Mediated Cardioprotection Against Ischemia/Reperfusion Injury.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Disease Models, Animal; Down-Regulation; Flow Cytometr | 2021 |
Anesthetic Propofol Promotes Tumor Metastasis in Lungs via GABA
Topics: Anesthetics, Intravenous; Animals; Disease Models, Animal; Female; Lung Neoplasms; Mice; Mice, Inbre | 2021 |
Propofol attenuates lung ischemia/reperfusion injury though the involvement of the MALAT1/microRNA-144/GSK3β axis.
Topics: Anesthetics, Intravenous; Animals; Autophagy; Biomarkers; Cytokines; Disease Models, Animal; Disease | 2021 |
Propofol protects cardiomyocytes from hypoxia/reoxygenation injury via regulating MALAT1/miR-206/ATG3 axis.
Topics: Animals; Apoptosis; Autophagy-Related Proteins; Cell Hypoxia; Cell Line; Disease Models, Animal; Dow | 2021 |
Propofol Downregulates lncRNA MALAT1 to Alleviate Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis; Brain; Disease Models, Animal; Down-Regulation; Infarction, Middle Cerebral Arte | 2021 |
Autism-like behavior in the BTBR mouse model of autism is improved by propofol.
Topics: Adaptation, Ocular; Analysis of Variance; Anesthetics, Intravenous; Animals; Autistic Disorder; Dise | 2017 |
Sevoflurane Posttreatment Attenuates Lung Injury Induced by Oleic Acid in Dogs.
Topics: Acute Lung Injury; Anesthetics, Inhalation; Animals; Arterial Pressure; Cytoprotection; Disease Mode | 2017 |
Effects of ketamine, dexmedetomidine and propofol anesthesia on emotional memory consolidation in rats: Consequences for the development of post-traumatic stress disorder.
Topics: Animals; Avoidance Learning; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Dr | 2017 |
Propofol Sedation Exacerbates Kidney Pathology and Dissemination of Bacteria during Staphylococcus aureus Bloodstream Infections.
Topics: Animals; Bacteremia; Bacterial Load; Dendritic Cells; Disease Models, Animal; Disease Susceptibility | 2017 |
Propofol inhibits NF-κB activation to ameliorate airway inflammation in ovalbumin (OVA)-induced allergic asthma mice.
Topics: Allergens; Anesthetics; Animals; Anti-Allergic Agents; Asthma; Cell Line; Disease Models, Animal; Hu | 2017 |
Effects of propofol and surgery on neuropathology and cognition in the 3xTgAD Alzheimer transgenic mouse model.
Topics: Alzheimer Disease; Anesthesia, Inhalation; Animals; Brain; Cognition; Cognition Disorders; Disease M | 2017 |
Impact of Anesthetic Regimen on Remote Ischemic Preconditioning in the Rat Heart In Vivo.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Disease Models, Anim | 2018 |
KIF17 mediates the learning and memory impairment in offspring induced by maternal exposure to propofol during middle pregnancy.
Topics: Animals; Biomarkers; Disease Models, Animal; Female; Hippocampus; Kinesins; Learning Disabilities; M | 2018 |
Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits.
Topics: Animals; Axonal Transport; Behavior, Animal; Botulinum Toxins; Brain; Disease Models, Animal; Growth | 2018 |
Zebrafish: A Pharmacogenetic Model for Anesthesia.
Topics: Anesthesia; Anesthetics; Animals; Animals, Genetically Modified; Behavior, Animal; Biotransformation | 2018 |
The interplay of BDNF-TrkB with NMDA receptor in propofol-induced cognition dysfunction : Mechanism for the effects of propofol on cognitive function.
Topics: Animals; Behavior, Animal; Blotting, Western; Brain-Derived Neurotrophic Factor; Cognitive Dysfuncti | 2018 |
PKA-CREB-BDNF signaling pathway mediates propofol-induced long-term learning and memory impairment in hippocampus of rats.
Topics: Animals; Animals, Newborn; Apoptosis; Brain-Derived Neurotrophic Factor; CREB-Binding Protein; Cycli | 2018 |
Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer's disease mice.
Topics: Alzheimer Disease; Anesthetics, Intravenous; Animals; Blotting, Western; Brain; Disease Models, Anim | 2018 |
The influence of propofol anesthesia exposure on nonaversive memory retrieval and expression of molecules involved in memory process in the dorsal hippocampus in peripubertal rats.
Topics: Animals; Behavior, Animal; Blotting, Western; Disease Models, Animal; Hippocampus; Hypnotics and Sed | 2018 |
Dexmedetomidine and propofol sedation requirements in an autistic rat model.
Topics: Animals; Animals, Newborn; Autistic Disorder; Dexmedetomidine; Disease Models, Animal; Electroenceph | 2019 |
Interaction between anesthetic conditioning and ischemic preconditioning on metabolic function after hepatic ischemia-reperfusion in rabbits.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Disease Models, Animal; Hemodynamics; Ischemic Precond | 2018 |
Anesthetics alleviate learning and memory impairment induced by electroconvulsive shock by regulation of NMDA receptor-mediated metaplasticity in depressive rats.
Topics: Anesthetics; Animals; Behavior, Animal; Cognitive Dysfunction; Depression; Disease Models, Animal; E | 2018 |
The recovery from transient cognitive dysfunction induced by propofol was associated with enhanced autophagic flux in normal healthy adult mice.
Topics: Anesthetics, Intravenous; Animals; Autophagy; Cognition; Cognitive Dysfunction; Disease Models, Anim | 2018 |
Balancing Tricks and Mini-pigs: Steps along the Road to Propofol.
Topics: Anesthesia; Animals; Awards and Prizes; Disease Models, Animal; History, 21st Century; Humans; Propo | 2018 |
Effect of cholinergic crisis on the potency of different emergency anaesthesia protocols in soman-poisoned rats.
Topics: Acetylcholinesterase; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; Animals | 2019 |
Comparison of inhaled versus intravenous anesthesia for laryngoscopy and laryngeal electromyography in a rat model.
Topics: Anesthesia, Intravenous; Anesthetics, Inhalation; Animals; Disease Models, Animal; Electromyography; | 2018 |
Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice.
Topics: Administration, Intranasal; Aging; Anesthesia; Anesthetics, Intravenous; Animals; Brain; Cognitive D | 2019 |
Propofol attenuates inflammatory damage on neurons following cerebral infarction by inhibiting excessive activation of microglia.
Topics: Actins; Animals; Brain Infarction; Cell Death; Cell Movement; Cell Proliferation; Cytoskeleton; Dise | 2019 |
Volatile Anesthetic Attenuates Phagocyte Function and Worsens Bacterial Loads in Wounds.
Topics: Adolescent; Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Bacterial Load; Cardi | 2019 |
Propofol partially attenuates complete freund's adjuvant-induced neuroinflammation through inhibition of the ERK1/2/NF-κB pathway.
Topics: Animals; Disease Models, Animal; Freund's Adjuvant; Gene Expression Regulation; Humans; Inflammation | 2019 |
Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Disease Models, Animal; Guanine Nucleoti | 2019 |
The role of PI3K/Akt signal pathway in the protective effects of propofol on intestinal and lung injury induced by intestinal ischemia/reperfusion1.
Topics: Anesthetics, Intravenous; Animals; Disease Models, Animal; Lung Injury; Male; Mesenteric Ischemia; P | 2019 |
Propofol Protects Lung Endothelial Barrier Function by Suppression of High-Mobility Group Box 1 (HMGB1) Release and Mitochondrial Oxidative Damage Catalyzed by HMGB1.
Topics: Acute Lung Injury; Animals; Catalysis; Disease Models, Animal; Endothelial Cells; Endothelium, Vascu | 2019 |
Propofol can suppress renal ischemia-reperfusion injury through the activation of PI3K/AKT/mTOR signal pathway.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cytokines; Disease Models, Animal; Drug Evaluation, Preclin | 2019 |
Propofol Induces Postoperative Depression and Inhibits Microglial Function in Mice.
Topics: Anesthesia, Intravenous; Animals; Anxiety; Brain; CD11b Antigen; Depression; Disease Models, Animal; | 2019 |
Effects of propofol on myocardial ischemia reperfusion injury through inhibiting the JAK/STAT pathway.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation; Janus Kinase 1; L-Lactate Dehydrogenase | 2019 |
Effect of propofol on myocardial ischemia/reperfusion injury in rats through JAK/STAT signaling pathway.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation; Janus Kinase 2; Male; Myocardial Reperf | 2019 |
Propofol and thiopental suppress amyloid fibril formation and GM1 ganglioside expression through the γ-aminobutyric acid A receptor.
Topics: Amyloid; Anesthetics, Intravenous; Animals; Cell Membrane; Cell-Free System; Cells, Cultured; Diseas | 2013 |
Propofol attenuates renal ischemia-reperfusion injury aggravated by hyperglycemia.
Topics: Anesthetics, Intravenous; Animals; Antioxidants; Comorbidity; Disease Models, Animal; Etomidate; Hyp | 2013 |
Coadministration of the AMPAKINE CX717 with propofol reduces respiratory depression and fatal apneas.
Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Apnea; Disease Models, Animal; Drug Therapy, Co | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Sevoflurane, but not propofol, reduces the lung inflammatory response and improves oxygenation in an acute respiratory distress syndrome model: a randomised laboratory study.
Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cell Membrane Permeability; Disease Models, Animal; He | 2013 |
Isoflurane in contrast to propofol promotes fluid extravasation during cardiopulmonary bypass in pigs.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Cardiopulmonary Bypass; Disease Models, | 2013 |
Real-time closed-loop control in a rodent model of medically induced coma using burst suppression.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Brain; Coma; Disease Models, Animal; Dru | 2013 |
Isoflurane suppresses cortical spreading depolarizations compared to propofol--implications for sedation of neurocritical care patients.
Topics: Animals; Cerebrovascular Circulation; Cortical Spreading Depression; Disease Models, Animal; Dose-Re | 2014 |
Effects of propofol on expression of hippocampal neuronal nitric oxide synthase and carboxy-terminal PDZ ligand of neuronal nitric oxide synthase in stressed rats undergoing electroconvulsive shock.
Topics: Adaptor Proteins, Signal Transducing; Animals; Depressive Disorder; Disease Models, Animal; Electros | 2013 |
Propofol protects against focal cerebral ischemia via inhibition of microglia-mediated proinflammatory cytokines in a rat model of experimental stroke.
Topics: Animals; Biomarkers; Brain Ischemia; Cytokines; Disease Models, Animal; Gene Expression; Infarction, | 2013 |
Sedation using propofol induces similar diaphragm dysfunction and atrophy during spontaneous breathing and mechanical ventilation in rats.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Diaphragm; Disease Models, Animal; Male; Mu | 2014 |
Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloidogenic Proteins; Animals; Brain; Caspases; Cell Line, Tumor; Cognit | 2014 |
Propofol activation of the Nrf2 pathway is associated with amelioration of acute lung injury in a rat liver transplantation model.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Heme Oxygenase-1; Hydrogen Peroxide; Intracellul | 2014 |
Effects of repetitive exposure to anesthetics and analgesics in the Tg2576 mouse Alzheimer's model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analgesics; Anesthetics; A | 2014 |
(R)-alpha-methylhistamine suppresses inhibitory neurotransmission in hippocampal CA1 pyramidal neurons counteracting propofol-induced amnesia in rats.
Topics: Action Potentials; Amnesia; Anesthetics, Intravenous; Animals; CA1 Region, Hippocampal; Disease Mode | 2014 |
Propofol inhibits inflammatory cytokine-mediated glutamate uptake dysfunction to alleviate learning/memory impairment in depressed rats undergoing electroconvulsive shock.
Topics: Analysis of Variance; Animals; Cytokines; Depression; Disease Models, Animal; Food Deprivation; Food | 2015 |
[Effects of continuous sedation with propofol on peripheral blood mononuclear cell and intercellular adhesion molecule in beagles with combined burn-blast injuries].
Topics: Animals; Apoptosis; Blast Injuries; Burns; Disease Models, Animal; Dogs; Hypnotics and Sedatives; In | 2014 |
Effects of short-term propofol and dexmedetomidine on pulmonary morphofunction and biological markers in experimental mild acute lung injury.
Topics: Acute Lung Injury; Animals; Cytokines; Dexmedetomidine; Disease Models, Animal; Endotoxins; Female; | 2014 |
Propofol attenuated acute kidney injury after orthotopic liver transplantation via inhibiting gap junction composed of connexin 32.
Topics: Acute Kidney Injury; Anesthetics, Intravenous; Animals; Blotting, Western; Cell Culture Techniques; | 2015 |
Propofol alleviates acute lung injury following orthotopic autologous liver transplantation in rats via inhibition of the NADPH oxidase pathway.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Hypnotics and Sedatives; Liver Transplantation; | 2015 |
Orexin-B antagonized respiratory depression induced by sevoflurane, propofol, and remifentanil in isolated brainstem-spinal cords of neonatal rats.
Topics: Anesthetics; Animals; Animals, Newborn; Brain Stem; Disease Models, Animal; Intracellular Signaling | 2015 |
Propofol prevents neuronal mtDNA deletion and cerebral damage due to ischemia/reperfusion injury in rats.
Topics: Animals; Brain Ischemia; Disease Models, Animal; DNA, Mitochondrial; Hippocampus; Male; Membrane Pot | 2015 |
The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats.
Topics: Acute Disease; Animals; Brain Ischemia; CA1 Region, Hippocampal; Carboxylic Acids; Cell Survival; Di | 2015 |
Propofol pretreatment attenuates remote kidney injury induced by orthotopic liver autotransplantation, which is correlated with the activation of Nrf2 in rats.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Heme Oxygenas | 2015 |
Dexmedetomidine Attenuates Neurotoxicity Induced by Prenatal Propofol Exposure.
Topics: Anesthetics, Intravenous; Animals; Blotting, Western; Brain; Calcium-Binding Proteins; Caspase 3; De | 2016 |
Propofol increases morbidity and mortality in a rat model of sepsis.
Topics: Anesthetics, Intravenous; Animals; Disease Models, Animal; Male; Propofol; Rats; Rats, Wistar; Respi | 2015 |
Endocannabinoid-mediated improvement on a test of aversive memory in a mouse model of fragile X syndrome.
Topics: Amidohydrolases; Animals; Anxiety; Arachidonic Acids; Avoidance Learning; Benzamides; Cannabinoid Re | 2015 |
Methodology of motor evoked potentials in a rabbit model.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Apnea; Disease Models, Animal; Evoked Po | 2015 |
Anesthetic propofol overdose causes vascular hyperpermeability by reducing endothelial glycocalyx and ATP production.
Topics: Adenosine Triphosphate; Anesthetics; Animals; Capillary Permeability; Cell Line; Cells, Cultured; Di | 2015 |
Propofol Pretreatment Fails to Provide Neuroprotection Following a Surgically Induced Brain Injury Rat Model.
Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Brain; Brain Edema; Brain Injuries; Disease Mod | 2016 |
Effects of Propofol on Excitatory and Inhibitory Amino Acid Neurotransmitter Balance in Rats with Neurogenic Pulmonary Edema Induced by Subarachnoid Hemorrhage.
Topics: Animals; Brain; Brain Edema; Disease Models, Animal; Excitatory Amino Acids; gamma-Aminobutyric Acid | 2016 |
The effect of propofol and sevoflurane on antioxidants and proinflammatory cytokines in a porcine ischemia-reperfusion model.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Methyl Ethers; Myocytes, Sm | 2016 |
Mechanisms of propofol attenuation of ketamine-induced neonatal brain injury.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Brain Diseases; Cognition Disorders; Disease Models, A | 2016 |
Function of SOD1, SOD2, and PI3K/AKT signaling pathways in the protection of propofol on spinal cord ischemic reperfusion injury in a rabbit model.
Topics: Animals; Disease Models, Animal; Male; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Propo | 2016 |
Propofol Protects Rats and Human Alveolar Epithelial Cells Against Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting HMGB1 Expression.
Topics: Acute Lung Injury; Alveolar Epithelial Cells; Animals; Disease Models, Animal; Gene Expression; HMGB | 2016 |
Propofol alleviates electroconvulsive shock-induced memory impairment by modulating proBDNF/mBDNF ratio in depressive rats.
Topics: Anesthetics, Intravenous; Animals; Brain-Derived Neurotrophic Factor; Depressive Disorder; Disease M | 2016 |
Propofol administration improves neurological function associated with inhibition of pro-inflammatory cytokines in adult rats after traumatic brain injury.
Topics: Animals; Behavior, Animal; Brain Injuries, Traumatic; Cytokines; Disease Models, Animal; Encephaliti | 2016 |
The Effects of Two Anesthetics, Propofol and Sevoflurane, on Liver Ischemia/Reperfusion Injury.
Topics: Animals; bcl-2-Associated X Protein; Disease Models, Animal; Interleukin-1; Interleukin-6; Liver; Ma | 2016 |
Glucocorticoid receptor mediated the propofol self-administration by dopamine D1 receptor in nucleus accumbens.
Topics: Aldosterone; Animals; Corticosterone; Dexamethasone; Disease Models, Animal; Dose-Response Relations | 2016 |
Propofol Mitigates Learning and Memory Impairment After Electroconvulsive Shock in Depressed Rats by Inhibiting Autophagy in the Hippocampus.
Topics: Animals; Autophagy; Depression; Depressive Disorder; Disease Models, Animal; Electroconvulsive Thera | 2016 |
Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats.
Topics: Analgesics; Animals; Apoptosis; bcl-2-Associated X Protein; Biomarkers; Blood Gas Analysis; Caspase | 2016 |
Neuroprotective effect of propofol against excitotoxic injury to locomotor networks of the rat spinal cord in vitro.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Kainic Acid; Locomotion; Motor Neurons; Neuro | 2016 |
Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.
Topics: Animals; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucuron | 2016 |
Etanercept, an inhibitor of TNF-a, prevents propofol-induced neurotoxicity in the developing brain.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroida | 2016 |
Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury.
Topics: Acute Lung Injury; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Anti-Inflammatory Age | 2017 |
Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury.
Topics: Acute Lung Injury; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Anti-Inflammatory Age | 2017 |
Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury.
Topics: Acute Lung Injury; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Anti-Inflammatory Age | 2017 |
Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury.
Topics: Acute Lung Injury; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Anti-Inflammatory Age | 2017 |
Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury.
Topics: Acute Lung Injury; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Anti-Inflammatory Age | 2017 |
Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury.
Topics: Acute Lung Injury; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Anti-Inflammatory Age | 2017 |
Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury.
Topics: Acute Lung Injury; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Anti-Inflammatory Age | 2017 |
Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury.
Topics: Acute Lung Injury; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Anti-Inflammatory Age | 2017 |
Sevoflurane Abolishes Oxygenation Impairment in a Long-Term Rat Model of Acute Lung Injury.
Topics: Acute Lung Injury; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Anti-Inflammatory Age | 2017 |
Protective effect of propofol on noise-induced hearing loss.
Topics: Animals; Blood Pressure; Cell Count; Cochlea; Dinoprost; Disease Models, Animal; Enzyme-Linked Immun | 2017 |
Effects of Propofol on Oxidative Stress Parameters in Selected Parts of the Brain in a Rat Model of Parkinson Disease.
Topics: Animals; Antioxidants; Brain; Disease Models, Animal; Hypnotics and Sedatives; Male; Oxidative Stres | 2016 |
Anaesthetic-induced cardioprotection in an experimental model of the Takotsubo syndrome - isoflurane vs. propofol.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Disease Models, Animal; Echocardiography | 2017 |
[Comparison of propofol concentration in the spinal cord between intra-aortic and intravenous infusion].
Topics: Animals; Blood Pressure; Disease Models, Animal; Female; Heart Rate; Infusions, Intravenous; Injecti | 2008 |
Direct assessments of the antioxidant effects of propofol medium chain triglyceride/long chain triglyceride on the brain of stroke-prone spontaneously hypertensive rats using electron spin resonance spectroscopy.
Topics: Anesthetics, Intravenous; Animals; Antioxidants; Brain; Cerebrovascular Circulation; Disease Models, | 2008 |
Anaesthetic drugs and defibrillation threshold testing.
Topics: Anesthetics; Animals; Defibrillators, Implantable; Differential Threshold; Disease Models, Animal; D | 2008 |
Targeted minute ventilation and tidal volume in an animal model of acute changes in lung mechanics and episodes of hypoxemia.
Topics: Animals; Apnea; Calibration; Disease Models, Animal; Hypoxia; Intermittent Positive-Pressure Ventila | 2009 |
Effects of propofol on pro-inflammatory cytokines and nuclear factor kappaB during polymicrobial sepsis in rats.
Topics: Animals; Cecum; Cytokines; Disease Models, Animal; Hemodynamics; Hepatic Duct, Common; Histocytochem | 2009 |
Propofol: neuroprotection in an in vitro model of traumatic brain injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; Hypnotics and Sed | 2009 |
Acetaminophen-induced liver injury and oxidative stress: protective effect of propofol.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Intravenous; Animals; Antioxidants; Data Inter | 2009 |
[The influences of propofol on corticosteroid and immunity of rats after hemorrhagic shock and resuscitation].
Topics: Animals; Disease Models, Animal; Hydrocortisone; Interferon-gamma; Interleukin-4; Intestine, Small; | 2009 |
Cardiac electrophysiological effects of remifentanil: study in a closed-chest porcine model.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Animals; Atrioventricular Node; Carbon Dioxide; Diseas | 2009 |
[Propofol provides ischemic postconditioning on myocardial ischemia-reperfusion injury in rats].
Topics: Animals; Apoptosis; Caspase 3; Disease Models, Animal; Female; Male; Myocardial Reperfusion Injury; | 2009 |
Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics.
Topics: Anesthetics, General; Animals; Brain; Consciousness Disorders; Convulsants; Disease Models, Animal; | 2009 |
The comparison of the effects of anesthetic doses of ketamine, propofol, and etomidate on ischemia-reperfusion injury in skeletal muscle.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Disease Models, Animal; Etomidate; Fem | 2010 |
The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats.
Topics: Androstadienes; Animals; Brain; Brain Infarction; Disease Models, Animal; Dose-Response Relationship | 2009 |
The protective effects of propofol and citicoline combination in experimental head injury in rats.
Topics: Animals; Blood Pressure; Craniocerebral Trauma; Cytidine Diphosphate Choline; Disease Models, Animal | 2010 |
[Effect of propofol upon brain after whole-body hyperthermia in rats].
Topics: Animals; Apoptosis; Brain; Disease Models, Animal; Heat Stress Disorders; Hippocampus; Male; Neurons | 2009 |
Bolus oral or continuous intestinal amino acids reduce hypothermia during anesthesia in rats.
Topics: Administration, Oral; Amino Acids; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intrav | 2010 |
Effects of electroconvulsive therapy and propofol on spatial memory and glutamatergic system in hippocampus of depressed rats.
Topics: Animals; Combined Modality Therapy; Depression; Disease Models, Animal; Electroconvulsive Therapy; G | 2010 |
Apoptosis: understanding programmed cell death for the CRNA.
Topics: Anesthetics; Animals; Antioxidants; Apoptosis; Comorbidity; Disease Models, Animal; Drug Monitoring; | 2010 |
Propofol pretreatment increases antidepressant-like effects induced by acute administration of ketamine in rats receiving forced swimming test.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Dis | 2011 |
The effects of propofol on hippocampal caspase-3 and Bcl-2 expression following forebrain ischemia-reperfusion in rats.
Topics: Anesthetics, Intravenous; Animals; Caspase 3; Disease Models, Animal; Hippocampus; Hypoxia-Ischemia, | 2010 |
Effects of anesthetic propofol on release of amino acids from the spinal cord during visceral pain.
Topics: Amino Acids; Anesthetics, Intravenous; Animals; Disease Models, Animal; Male; Muscle Contraction; No | 2010 |
The anticonvulsant effects of propofol and a propofol analog, 2,6-diisopropyl-4-(1-hydroxy-2,2,2-trifluoroethyl)phenol, in a 6 Hz partial seizure model.
Topics: Animals; Anticonvulsants; Ataxia; Disease Models, Animal; Dose-Response Relationship, Drug; Electric | 2011 |
Propofol inhibits lipopolysaccharide-induced lung epithelial cell injury by reducing hypoxia-inducible factor-1alpha expression.
Topics: Acute Lung Injury; Anesthetics, Intravenous; Animals; Apoptosis; Cells, Cultured; Cytokines; Disease | 2011 |
Possible role of propofol's cyclooxygenase-inhibiting property in alleviating dopaminergic neuronal loss in the substantia nigra in an MPTP-induced murine model of Parkinson's disease.
Topics: Animals; Blotting, Western; Cell Separation; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Ani | 2011 |
Effects of propofol on the outcomes of rats with sepsis.
Topics: Anesthetics, Intravenous; Animals; Cecum; Disease Models, Animal; Heart; HMGB1 Protein; Injections, | 2011 |
Optically measured NADH concentrations are unaffected by propofol induced EEG silence during transient cerebral hypoperfusion in anesthetized rabbits.
Topics: Anesthetics, Intravenous; Animals; Brain; Brain Waves; Cerebrovascular Circulation; Disease Models, | 2011 |
Can propofol cause seizures? an experimental study.
Topics: Animals; Apoptosis; Convulsants; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationsh | 2011 |
Influence of haemorrhage on the pseudo-steady-state remifentanil concentration in a swine model: a comparison with propofol and the effect of haemorrhagic shock stage.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Blood Pressure; Blood Volume; Cardiac Outpu | 2011 |
The involvement of adenosine triphosphate-sensitive potassium channels in the different effects of sevoflurane and propofol on glucose metabolism in fed rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Glucose; Blood Pressure; Disease M | 2012 |
Antioxidant effects of propofol on tourniquet-induced ischemia-reperfusion injury: an experimental study.
Topics: Anesthetics, Intravenous; Animals; Antioxidants; Catalase; Disease Models, Animal; Femoral Artery; G | 2012 |
Propofol interacts with stimulus intensities of electroconvulsive shock to regulate behavior and hippocampal BDNF in a rat model of depression.
Topics: Anesthetics; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Disease Model | 2012 |
Propofol attenuates hepatic ischemia/reperfusion injury in an in vivo rabbit model.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hemodynamics; Liver; Male; Propof | 2012 |
Neuroprotective effects of propofol, thiopental, etomidate, and midazolam in fetal rat brain in ischemia-reperfusion model.
Topics: Animals; Disease Models, Animal; Embryo, Mammalian; Etomidate; Female; Lipid Peroxidation; Male; Mic | 2012 |
Ischemia-reperfusion-induced unmeasured anion generation and glycocalyx shedding: sevoflurane versus propofol anesthesia.
Topics: Acid-Base Equilibrium; Anesthetics; Animals; Capillary Permeability; Disease Models, Animal; Endothe | 2012 |
Effects of propofol and dexmedetomidine on motor coordination and analgesia: a comparative analysis.
Topics: Analgesics; Animals; Behavior, Animal; Dexmedetomidine; Disease Models, Animal; Hot Temperature; Mal | 2012 |
Effects of propofol and dizocilpine maleate on the cognitive abilities and the hyperphosphorylation of Tau protein of rats after the electroconvulsive therapy.
Topics: Animals; Depression; Disease Models, Animal; Dizocilpine Maleate; Electroconvulsive Therapy; Glutami | 2012 |
Breath pentane as a potential biomarker for survival in hepatic ischemia and reperfusion injury--a pilot study.
Topics: Anesthetics, Intravenous; Animals; Aspartate Aminotransferases; Biomarkers; Disease Models, Animal; | 2012 |
Assessment of propofol, midazolam and ziprasidone, or the combinations for the prevention of acute cocaine toxicity in a mouse model.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Cocaine-Related Disorders; Disease Models, Animal; D | 2013 |
Propofol administration to the fetal-maternal unit reduces cardiac injury in late-preterm lambs subjected to severe prenatal asphyxia and cardiac arrest.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Animals, Newborn; Asphyxia Neonatorum; B | 2013 |
Intravenous induction agents: propofol.
Topics: Anesthetics, Intravenous; Animals; Clinical Trials as Topic; Disease Models, Animal; Dose-Response R | 2002 |
Effects of ketamine and propofol on the ratio of interleukin-6 to interleukin-10 during endotoxemia in rats.
Topics: Anesthetics, Dissociative; Animals; Disease Models, Animal; Endotoxins; Hemodynamics; Hypnotics and | 2003 |
Comparison of isoflurane and propofol-fentanyl anaesthesia in a swine model of asphyxia.
Topics: Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Asphyxia; Blood P | 2003 |
[Therapeutic effect of intravenous anesthetic propofol on experimental model of status epilepticus].
Topics: Anesthetics, Intravenous; Animals; Brain; Disease Models, Animal; Electroencephalography; Glucose; M | 2004 |
Comparative effects of thiopental and propofol on atrial vulnerability: electrophysiological study in a porcine model including acute alcoholic intoxication.
Topics: Alcoholic Intoxication; Anesthetics, Intravenous; Animals; Arrhythmias, Cardiac; Atrial Flutter; Atr | 2004 |
Chronic ethanol consumption does not affect action of propofol on rat hippocampal acetylcholine release in vivo.
Topics: Acetylcholine; Alcoholism; Anesthetics, Intravenous; Animals; Chromatography, High Pressure Liquid; | 2004 |
Developing yet another spinal analgesic drug?
Topics: Analgesia; Analgesics; Animals; Disease Models, Animal; Injections, Spinal; Pain; Propofol; Rats | 2004 |
Intrathecal propofol has analgesic effects on inflammation-induced pain in rats.
Topics: Analgesics; Animals; Disease Models, Animal; Formaldehyde; Hot Temperature; Inflammation; Injections | 2004 |
[Propofol reduces intercellular adhesion molecular-1 expression in lung injury following intestinal ischemia/reperfusion in rats].
Topics: Animals; Disease Models, Animal; Female; Intercellular Adhesion Molecule-1; Intestines; Lung Injury; | 2005 |
The effects of ketamine and propofol on bacterial translocation in rats after burn injury.
Topics: Analgesics; Anesthetics, Intravenous; Animals; Bacterial Translocation; Blood Pressure; Burns; Disea | 2005 |
[Comparison of pentobarbital and propofol on the outcome of focal cerebral ischemia model in rats].
Topics: Adjuvants, Anesthesia; Anesthetics, Intravenous; Animals; Brain Ischemia; Disease Models, Animal; In | 2004 |
Propofol attenuates oxidant-induced acute lung injury in an isolated perfused rabbit-lung model.
Topics: Animals; Antioxidants; Catalase; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen | 2005 |
Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats.
Topics: Anesthetics; Animals; Brain; Brain Injuries; Cell Survival; Cognition Disorders; Diazepam; Disease M | 2006 |
The effect of propofol on astro- and microglial reactivity in the course of experimental intracerebral haemorrhage in rats.
Topics: Anesthetics, Intravenous; Animals; Astrocytes; Cerebral Hemorrhage; Disease Models, Animal; Immunohi | 2006 |
Laboratory investigation: effects of propofol on the systemic inflammatory response during aortic surgery.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Aorta; Creatinine; Disease Models, Anima | 2006 |
Cardiovascular changes after naloxone administration in propofol-sedated piglets during opioid overdose.
Topics: Analgesics, Opioid; Animals; Carbon Dioxide; Cardiovascular Physiological Phenomena; Catecholamines; | 2006 |
Functional abnormalities of the motor tract in the rat after portocaval anastomosis and after carbon tetrachloride induction of cirrhosis.
Topics: Anastomosis, Surgical; Anesthetics, Intravenous; Animals; Carbon Tetrachloride; Disease Models, Anim | 2006 |
[Influence of propofol on Gq/11 protein in kidney during acute respiratory distress syndrome].
Topics: Animals; Disease Models, Animal; GTP-Binding Protein alpha Subunits, Gq-G11; Kidney; Male; Propofol; | 2006 |
Comparison of propofol and isoflurane anesthesia in orthotopic pig-to-baboon cardiac xenotransplantation.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Pressure; Cen | 2007 |
Investigation of the relaxant effects of propofol on ovalbumin-induced asthma in guinea pigs.
Topics: Animals; Asthma; Calcium Channels; Disease Models, Animal; Guinea Pigs; Hypnotics and Sedatives; Iso | 2007 |
Effects of propofol and halothane on long-term potentiation in the rat hippocampus after transient cerebral ischaemia.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Carotid Artery, Common; Dentate Gyrus; D | 2007 |
The oxidative status of blood cells in a murine model of graft-versus-host disease.
Topics: Acetylcysteine; Animals; Blood Cells; Cells, Cultured; Disease Models, Animal; Female; Flow Cytometr | 2007 |
The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia.
Topics: Anesthetics, Intravenous; Animals; Anti-Inflammatory Agents; Blood Gas Analysis; Blood Pressure; Dis | 2007 |
Propofol attenuates ischaemia-reperfusion injury in the rat heart in vivo.
Topics: Anesthetics, Intravenous; Animals; Antioxidants; Blood Pressure; Cardiotonic Agents; Disease Models, | 2008 |
Neonatal exposure to a combination of N-methyl-D-aspartate and gamma-aminobutyric acid type A receptor anesthetic agents potentiates apoptotic neurodegeneration and persistent behavioral deficits.
Topics: Analgesics; Anesthetics, Combined; Anesthetics, Intravenous; Animals; Animals, Newborn; Anti-Anxiety | 2007 |
Propofol and erythropoietin antioxidant properties in rat brain injured tissue.
Topics: Analysis of Variance; Animals; Antioxidants; Brain Chemistry; Catalase; Disease Models, Animal; Eryt | 2008 |
Effect of propofol on pathologic time-course and apoptosis after cerebral ischemia-reperfusion injury.
Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Edema; Male; Neurons; Propofol; Proto-On | 2008 |
[Effect of propofol on gastric mucosal injury after hemorrhagic shock and reperfusion in rabbits].
Topics: Animals; Disease Models, Animal; Gastric Mucosa; Male; Malondialdehyde; Propofol; Rabbits; Random Al | 2008 |
Anesthetics and natural heme oxygenase-1 inducers: waiting for carbon monoxide?
Topics: Anesthetics; Animals; Anthocyanins; Antioxidants; Carbon Monoxide; Curcumin; Cytoprotection; Disease | 2008 |
Protective effects of propofol on acute lung injury induced by oleic acid in conscious rats.
Topics: Animals; Disease Models, Animal; Hemodynamics; Hypnotics and Sedatives; Male; Oleic Acid; Propofol; | 2008 |
Lung injury following thoracic aortic occlusion: comparison of sevoflurane and propofol anaesthesia.
Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Aorta, Thoracic; Arterial Oc | 2008 |
Onset of segmental relaxation dysfunction with decreased myocardial tissue perfusion: modulation by propofol.
Topics: Anesthetics, Intravenous; Animals; Coronary Circulation; Disease Models, Animal; Dogs; Heart Rate; H | 1995 |
Interactions between opioid drugs and propofol in laboratory models of seizures.
Topics: Analgesics, Opioid; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; | 1995 |
Pentobarbitone, but not propofol, produces pre-emptive analgesia in the rat formalin model.
Topics: Analgesics; Anesthesia, Intravenous; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde | 1994 |
Early assessment of neurologic deficits in the fluid percussion model of brain injury.
Topics: Anesthesia; Animals; Behavior, Animal; Blood Pressure; Brain Injuries; Brain Stem; Cats; Cerebral He | 1993 |
Porphyria, propofol and rats.
Topics: Anesthetics, Intravenous; Animals; Disease Models, Animal; Humans; Hypnotics and Sedatives; Porphyri | 1996 |
Porphyria, propofol and rats.
Topics: Anesthetics, Intravenous; Animals; Disease Models, Animal; Humans; Hypnotics and Sedatives; Porphyri | 1996 |
Effect of 2,6-diisopropylphenol on the delayed hippocampal cell loss following transient forebrain ischemia in the gerbil.
Topics: Animals; Brain Ischemia; Cell Death; Cell Survival; Disease Models, Animal; Gerbillinae; Hippocampus | 1996 |
The effects of intravenous anesthetics on intracranial pressure and cerebral perfusion pressure in two feline models of brain edema.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Blood Pressure; Brain Edema; Cats; Cerebrov | 1997 |
Left ventricular systolic and diastolic function is unaltered during propofol infusion in newborn swine.
Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Blood Pressure; Cardiac Output; Diastole; Disea | 1998 |
Alterations of bacterial clearance induced by propofol.
Topics: Anesthetics, Intravenous; Animals; Bacteremia; Blood Bactericidal Activity; Blood Pressure; Disease | 1999 |
Pre- versus postinjury effects of intravenous GABAergic anesthetics on formalin-induced Fos immunoreactivity in the rat spinal cord.
Topics: Adjuvants, Anesthesia; Analgesics; Analysis of Variance; Anesthetics; Anesthetics, Intravenous; Anim | 1999 |
Propofol does not affect the canine cardiac conduction system under autonomic blockade.
Topics: Anesthetics, Intravenous; Animals; Atrioventricular Node; Atropine; Autonomic Nerve Block; Blood Pre | 1999 |
Induction of atrial fibrillation and flutter in dogs using methacholine.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Atrial Fibrillation; Atrial Flutter; Car | 1999 |
[Effects of endothelin antagonists on isolated perfused murine livers in the early phase of warm ischemia-reperfusion injury under propofol anesthesia].
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Azepines; Bosentan; Disease Models, Anim | 1999 |
[Depressive effects of propofol on apoptotic injury and delayed neuronal death after forebrain ischemia in the rat--comparison with nitrous oxide-oxygen-isoflurane].
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2000 |
A new porcine model of reperfusion injury after lung transplantation.
Topics: Animals; Azaperone; Disease Models, Animal; Female; Hypnotics and Sedatives; Lung Transplantation; P | 1999 |
Heart block following propofol in a child.
Topics: Anesthetics, Intravenous; Animals; Atrioventricular Node; Child; Disease Models, Animal; Heart Block | 2000 |
Unexpected neurotoxicity of etoposide phosphate administered in combination with other chemotherapeutic agents after blood-brain barrier modification to enhance delivery, using propofol for general anesthesia, in a rat model.
Topics: Anesthesia, General; Anesthetics, Intravenous; Animals; Antineoplastic Agents; Antineoplastic Combin | 2000 |
Effectiveness of propofol pretreatment on the extent of deranged cerebral mitochondrial oxidative enzyme system after incomplete forebrain ischemia/reperfusion in rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Free Radical Scavengers; Mitoc | 2000 |
Propofol in subanesthetic doses terminates status epilepticus in a rodent model.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Propofol; Rats; Rats, Sprague-Dawley; Status | 2001 |
Anesthetic choice of halothane versus propofol: impact on experimental perioperative stroke.
Topics: Administration, Inhalation; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intrav | 2001 |
Propofol versus isoflurane anesthesia under hypothermic conditions: effects on intracranial pressure and local cerebral blood flow after diffuse traumatic brain injury in the rat.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Gas Analysis; Blood Pressure; Body | 2001 |
Propofol anticonvulsant activity in experimental epileptic status.
Topics: Action Potentials; Animals; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Male; P | 1992 |
Effect of propofol on the malignant hyperthermia susceptible pig model.
Topics: Anesthetics; Animals; Disease Models, Animal; Disease Susceptibility; Malignant Hyperthermia; Phenol | 1989 |