propofol and Digestive System Disorders

propofol has been researched along with Digestive System Disorders in 10 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Research

Studies (10)

Authors

Clinical Trials (7)

Trial Overview

Trial Outcomes

Number of Participants Who Experience Airway Maneuvers

In high risk patients (meeting at least of 1 of 3 criteria: ASA ≥ 3, BMI ≥ 30, those at risk for OSA) undergoing advanced endoscopy procedures, compare the number of participants who experience airway maneuvers (AMs) when sedated with propofol alone versus propofol in combination with benzodiazepines and opioids. (NCT01315158)
Timeframe: One day (during procedure)

Number of Participants Who Experience Other Sedation Related Complications

Compare the number of participants who experience other sedation related complications such as hypotension, hypoxemia and need for termination of the procedure between the two groups (NCT01315158)
Timeframe: One day (during procedure)

Number of Participants Who Experience Symptoms of Nausea and Vomiting Will be Compared Between the Two Groups

The number of participants who experience symptoms of nausea and vomiting in the two groups of patients will be recorded. This will be recorded during the follow-up phone call made 24-48 hours after the procedure. (NCT01315158)
Timeframe: 24-48 hours

Predictors of Sedation Related Complications as Measured by Early Procedure Termination for an Alternative Sedation Related Complication

(NCT01315158)
Timeframe: One year

Predictors of Sedation Related Complications as Measured by Hypopnea/Apnea (Defined as Fewer Than 6 Breaths/Minute Based on Capnography)

(NCT01315158)
Timeframe: One year

Predictors of Sedation Related Complications as Measured by the Incidences of Hypotension (Defined as Systolic Blood Pressure of Less Than 90mmHg or a Decrease of More Than 25% From Baseline)

(NCT01315158)
Timeframe: One year

Predictors of Sedation Related Complications as Measured by the Number of Participants Who Experience Hypoxemia (Defined as a Pulse Oximetry <90% for Any Duration)

(NCT01315158)
Timeframe: One year

Duration of Recovery After the Endoscopic Procedure

"After completion of the procedure, the patient stood in the examination room monitored continuously by a nurse. When patients responded to normal verbal command, they were asked to sit up and were offered a drink. This was considered the early recovery time.~If they were able to stand unassisted by the bed and had stable hemodynamics parameters (saturation>90 % on room air and blood pressure and heart rate within 20 % of baseline), they were transferred to a locker room accompanied by a relative. The discharge criteria included ability to stand unassisted and tolerate clear liquids once dressed. Once a patient met discharge criteria, they were allowed to leave at their own discretion" (NCT01428882)
Timeframe: Up to 1 hour after colonoscopy

Level of Sedation Throughout the Entire Procedure

Assessment every two minutes of the level of sedation during the endoscopic procedure, rating it as minimal, moderate or deep. (NCT01428882)
Timeframe: Up to 1 hour after introduction of the colonoscope

Rate of Patients and Physician Satisfaction With Sedation

"Endoscopists and patients rated their satisfaction with sedation in a 10-cm visual analogue scale after discharge.The patients were contacted 24-48 h after the procedure to answer a questionnaire regarding if they remembered scope insertion or scope removal and willingness to repeat it with a similar protocol and rated their satisfaction and pain perception from 0 to 10. This phone survey was done by the nurse specifically making the measurements in the endoscopy room, who was blinded to the sedation regimen.~For the interpretation of results of the 0-10 point numerical scale, 0 stands for 'extremely dissatisfied with sedation level during the endoscopic procedure', whereas 10 stands for 'extremely satisfied with sedation level during the endoscopic procedure." (NCT01428882)
Timeframe: Up to 1 hour after colonoscopy for endoscopists and up to 48 hours for patients

Rate of Sedation-related Complications During the Procedure and the Recovery Phases

The following events were considered complications of procedural sedation: a decline in oxygen saturation to less than 85 % longer than 30 s after increasing the oxygen flow rate to 5 L/min and transient propofol interruption, a heart rate less than 40 beats per minute and blood pressure less than 80/50 mmHg. Major complications were defined as need for mechanical ventilation or any cardiorespiratory event requiring anaesthesiologist assistance. (NCT01428882)
Timeframe: Up to two hours, including colonoscopy performance and recovery period

Percentage of Participants in the Control Group With an Oxygen Saturation Less Than 90 % Who Responded to Rescue NIPPV

We used non-invasive positive pressure ventilation (NIPPV) as a first rescue maneuver in control patients who developed an oxygen desaturation less than 90 % and reported on the percentage of participants who responded. The rescue was considered successful with recovery of oxygen saturation more than 90 % within 3 minutes. (NCT03529461)
Timeframe: 3 minutes following a desaturation event < 90 %

Percentage of Participants With an Oxygen Desaturation Event < 90%

Percentage of participants who develop a peripheral oxygen saturation event < 90%. (NCT03529461)
Timeframe: Time in seconds beginning with the start of procedure (anesthesia induction) ending with procedure completion (eyes open to verbal stimuli).

Percentage of Participants With an Oxygen Desaturation Event ≤ 94%

Percentage of participants who develop a peripheral oxygen saturation measured by pulse oximetry ≤ 94% (NCT03529461)
Timeframe: Time in seconds beginning with the start of procedure (anesthesia induction) ending with procedure completion (eyes open to verbal stimuli).

Trials

3 trials available for propofol and Digestive System Disorders

Other Studies

7 other studies available for propofol and Digestive System Disorders