propofol has been researched along with Diabetes Mellitus, Adult-Onset in 17 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The IV anesthetic, propofol, when administered as fat emulsion-based formulation (Diprivan) promotes insulin resistance, but the direct effects of propofol and its solvent, Intralipid, on cardiac insulin resistance are unknown." | 7.81 | Propofol (Diprivan®) and Intralipid® exacerbate insulin resistance in type-2 diabetic hearts by impairing GLUT4 trafficking. ( Affolter, A; Clanachan, AS; Gandhi, M; Hersberger, M; Hornemann, T; Lou, PH; Lucchinetti, E; Zaugg, M; Zhakupova, A; Zhang, L, 2015) |
| "The IV anesthetic, propofol, when administered as fat emulsion-based formulation (Diprivan) promotes insulin resistance, but the direct effects of propofol and its solvent, Intralipid, on cardiac insulin resistance are unknown." | 3.81 | Propofol (Diprivan®) and Intralipid® exacerbate insulin resistance in type-2 diabetic hearts by impairing GLUT4 trafficking. ( Affolter, A; Clanachan, AS; Gandhi, M; Hersberger, M; Hornemann, T; Lou, PH; Lucchinetti, E; Zaugg, M; Zhakupova, A; Zhang, L, 2015) |
| "Propofol was associated with an increase in myocardial Bcl-2 protein expression (P = 0." | 2.82 | Propofol cardioprotection for on-pump aortocoronary bypass surgery in patients with type 2 diabetes mellitus (PRO-TECT II): a phase 2 randomized-controlled trial. ( Ansley, DM; Chen, DD; Choi, PT; Cook, RC; Raedschelders, K; Wang, B, 2016) |
| "A 67-year-old woman with hypertension, type 2 diabetes mellitus, and hypothyroidism presented for an elective blepharoplasty." | 1.91 | A 67-Year-Old Woman With Fluctuating Hypertension and Hypotension After Elective Surgery. ( Ho, C; Lau, C, 2023) |
| "Twelve subjects with type 2 diabetes and 12 body mass index and age-matched healthy subjects underwent anterograde and retrograde DBE under nurse-administered propofol sedation on two separate days." | 1.40 | The use of double-balloon enteroscopy in retrieving mucosal biopsies from the entire human gastrointestinal tract. ( Hassan, H; Hendel, JW; Holst, JJ; Knop, FK; Rhee, NA; Vilmann, P; Vilsbøll, T, 2014) |
| "Acarbose is a well-known drug used in type 2 diabetes treatment, particularly in the early phase." | 1.40 | [Acarbose and propofol: a dangerous combination?]. ( Beato-Pérez, JL; Martínez-Peguero, J; Polo-Romero, FJ; Rocha-Honor, E; Sánchez-Beteta, P; Santisteban-López, Y, 2014) |
| "Propofol has been reported to have an inhibitory effect on ischemia/reperfusion (I/R) injury in various experimental models by reducing oxidative stress, protecting mitochondrial function and suppressing apoptosis." | 1.39 | Effect and mechanism of propofol on myocardial ischemia reperfusion injury in type 2 diabetic rats. ( Deng, L; Ding, W; Gu, J; Li, D; Li, W; Lin, C; Sui, H; Yang, X; Yang, Y, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 10 (58.82) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Lau, C | 1 |
| Ho, C | 1 |
| Xiong, X | 1 |
| He, Y | 1 |
| Zhou, C | 1 |
| Zheng, Q | 1 |
| Chen, C | 1 |
| Liang, P | 1 |
| Koehestanie, P | 1 |
| Betzel, B | 1 |
| Dogan, K | 1 |
| Berends, F | 1 |
| Janssen, I | 1 |
| Aarts, E | 1 |
| Groenen, M | 1 |
| Wahab, P | 1 |
| Lin, C | 1 |
| Sui, H | 1 |
| Gu, J | 1 |
| Yang, X | 1 |
| Deng, L | 1 |
| Li, W | 1 |
| Ding, W | 1 |
| Li, D | 1 |
| Yang, Y | 1 |
| Rhee, NA | 1 |
| Vilmann, P | 1 |
| Hassan, H | 1 |
| Hendel, JW | 1 |
| Holst, JJ | 1 |
| Vilsbøll, T | 1 |
| Knop, FK | 1 |
| Lou, PH | 1 |
| Lucchinetti, E | 1 |
| Zhang, L | 1 |
| Affolter, A | 1 |
| Gandhi, M | 1 |
| Zhakupova, A | 1 |
| Hersberger, M | 1 |
| Hornemann, T | 1 |
| Clanachan, AS | 1 |
| Zaugg, M | 1 |
| Ansley, DM | 2 |
| Raedschelders, K | 2 |
| Choi, PT | 2 |
| Wang, B | 1 |
| Cook, RC | 1 |
| Chen, DD | 2 |
| Shi, R | 1 |
| Wu, J | 1 |
| Meng, C | 1 |
| Ma, B | 1 |
| Wang, T | 1 |
| Li, Y | 1 |
| Ma, Y | 1 |
| Cabaton, J | 1 |
| Rondelet, B | 1 |
| Gergele, L | 1 |
| Besnard, C | 1 |
| Piriou, V | 1 |
| Bui, AH | 1 |
| Marco, AP | 1 |
| Pedroviejo, V | 1 |
| García Mostaza, A | 1 |
| Pérez, J | 1 |
| Ayuso, M | 1 |
| Dewachter, P | 1 |
| Mouton-Faivre, C | 1 |
| Emala, CW | 1 |
| Beloucif, S | 1 |
| Rinehart, JB | 1 |
| Baker, B | 1 |
| Raphael, D | 1 |
| Rocha-Honor, E | 1 |
| Polo-Romero, FJ | 1 |
| Sánchez-Beteta, P | 1 |
| Martínez-Peguero, J | 1 |
| Santisteban-López, Y | 1 |
| Beato-Pérez, JL | 1 |
| Lynch, G | 1 |
| Clinton, S | 1 |
| Siotia, A | 1 |
| Cánovas, L | 1 |
| Domínguez, M | 1 |
| Diz, A | 1 |
| Castro, M | 1 |
| Barros, C | 1 |
| Castro, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Optimierung Der Kardioprotektion Durch Inhalative Anästhetika Eine Untersuchung Bei Patienten Mit Diabetes Mellitus während Off-pump Herzchirurgie[NCT02407626] | 2 participants (Actual) | Interventional | 2015-09-30 | Terminated (stopped due to Very low patient recruitment, changed insurance requirements) | |||
| PRO-TECT II: Propofol Cardioprotection for Type II Diabetics[NCT00734383] | Phase 2/Phase 3 | 137 participants (Actual) | Interventional | 2005-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for propofol and Diabetes Mellitus, Adult-Onset
13 other studies available for propofol and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
A 67-Year-Old Woman With Fluctuating Hypertension and Hypotension After Elective Surgery.
Topics: Aged; Dexmedetomidine; Diabetes Mellitus, Type 2; Female; Humans; Hypertension; Hypotension; Neuromu | 2023 |
Effect and mechanism of propofol on myocardial ischemia reperfusion injury in type 2 diabetic rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cytoprotection; Diabetes Mellitus, Experi | 2013 |
The use of double-balloon enteroscopy in retrieving mucosal biopsies from the entire human gastrointestinal tract.
Topics: Biopsy; Case-Control Studies; Diabetes Mellitus, Type 2; Double-Balloon Enteroscopy; Female; Humans; | 2014 |
Propofol (Diprivan®) and Intralipid® exacerbate insulin resistance in type-2 diabetic hearts by impairing GLUT4 trafficking.
Topics: Anesthetics, Intravenous; Animals; Citrate (si)-Synthase; Diabetes Mellitus, Type 2; Emulsions; Fat | 2015 |
Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.
Topics: Animals; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucuron | 2016 |
[Tako-Tsubo syndrome after anaphylaxis caused by succinylcholine during general anaesthesia].
Topics: Anaphylaxis; Anesthesia, General; Anesthesia, Intravenous; Diabetes Mellitus, Type 2; Female; Gastro | 2008 |
Peripheral nerve blockade in a patient with Charcot-Marie-Tooth disease.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Bupivacaine; Charcot-Marie-To | 2008 |
[Anesthesia during laparoscopic cholecystectomy in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS-syndrome)].
Topics: Adult; Androstanols; Anesthesia, Intravenous; Cholecystectomy, Laparoscopic; Cholelithiasis; Contrai | 2010 |
Case scenario: bronchospasm during anesthetic induction.
Topics: Adult; Albuterol; Anesthesia; Anesthetics, Intravenous; Anti-Inflammatory Agents; Bronchial Spasm; B | 2011 |
Postoperative global amnesia reversed with flumazenil.
Topics: Amnesia; Analgesics; Anesthesia, General; Cholangiopancreatography, Endoscopic Retrograde; Desfluran | 2012 |
[Acarbose and propofol: a dangerous combination?].
Topics: Acarbose; Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Chemical and Drug Induced Liver I | 2014 |
Anaesthesia and Alström's syndrome.
Topics: Adult; Anesthesia; Anesthetics, Intravenous; Atrial Fibrillation; Blindness; Deafness; Diabetes Mell | 2007 |
[General anesthesia using a laryngeal mask and anesthesia by epidural catheter in a case of Charcto-Marie-Tooth type I disease].
Topics: Adjuvants, Anesthesia; Analgesia, Epidural; Anesthesia, Inhalation; Anesthetics, Intravenous; Anesth | 1998 |