propofol has been researched along with Delirium of Mixed Origin in 128 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The delirium incidence was lower in the dexmedetomidine group than in the propofol group (11 [3." | 9.69 | Postoperative Delirium after Dexmedetomidine versus Propofol Sedation in Healthy Older Adults Undergoing Orthopedic Lower Limb Surgery with Spinal Anesthesia: A Randomized Controlled Trial. ( Do, SH; Han, SH; Hwang, JW; Kim, H; Na, HS; Shin, HJ; Woo Nam, S; Yim, S, 2023) |
| "This study aimed to explore the effects of different injection rates of propofol on postoperative cognition in elderly patients undergoing laparoscopic inguinal hernia repair." | 9.69 | Effects of Different Injection Rates of Propofol on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Inguinal Hernia Repair. ( Han, W; He, L; Hu, L; Li, T; Liu, J; Peng, L; Wang, S; Wang, Y; Xia, M; Yang, X, 2023) |
| " Propofol-remifentanil anesthesia was guided either by SedLine (EEG-guided care, n=779) or not (usual care, n=781)." | 9.51 | Effect of Electroencephalography Spectral Edge Frequency (SEF) and Patient State Index (PSI)-Guided Propofol-Remifentanil Anesthesia on Delirium After Laparoscopic Surgery: The eMODIPOD Randomized Controlled Trial. ( Dai, F; Gelb, AW; Guo, Q; Li, L; Li, Q; Liu, H; Luo, H; Luo, N; Meng, L; Song, Z; Wang, E; Wang, L; Ye, C; Zhang, Y; Zhong, Y; Zhu, M; Zou, Y, 2022) |
| "The primary objective of this study is to compare the impact of propofol and sevoflurane on the incidence of postoperative delirium for elderly patients undergoing spine surgery." | 9.51 | Impact of propofol versus sevoflurane on the incidence of postoperative delirium in elderly patients after spine surgery: study protocol of a randomized controlled trial. ( Chen, TT; Gao, Y; Lv, M; Wan, TT; Wang, JH; Wang, YL; Zhang, HX, 2022) |
| "Adding low-dose rate dexmedetomidine to a sedative regimen based on propofol did not result in a different risk of in-hospital delirium in older patients undergoing cardiac surgery." | 9.41 | Propofol plus low-dose dexmedetomidine infusion and postoperative delirium in older patients undergoing cardiac surgery. ( De Kerchove, L; Jacquet, LM; Kahn, D; Khalifa, C; Lemaire, G; Mastrobuoni, S; Momeni, M; Rosal Martins, M; Tircoveanu, R; Van Dyck, M; Watremez, C; Zango, SH, 2021) |
| "The key objective of this study is to assess whether remimazolam besylate reduces the incidence of delirium in patients after cardiac surgery compared to propofol sedation." | 9.41 | Effect of remimazolam besylate compared with propofol on the incidence of delirium after cardiac surgery: study protocol for a randomized trial. ( Bai, Y; Dong, R; Liu, X; Qin, B; Song, X; Tian, S; Yang, D; Yang, M, 2021) |
| "We set up to determine the incidence and duration of postoperative delirium in older patients who had surgery under the intravenous anesthetic propofol or the inhalational anesthetic sevoflurane." | 9.34 | The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study. ( Li, C; Ma, X; Marcantonio, E; Mei, X; Shen, Y; Xie, Z; Zheng, H; Zheng, HL, 2020) |
| "To evaluate the effect of postoperative intravenous (IV) acetaminophen (paracetamol) vs placebo combined with IV propofol vs dexmedetomidine on postoperative delirium among older patients undergoing cardiac surgery." | 9.30 | Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial. ( Banner-Goodspeed, V; Eikermann, M; Gallagher, J; Gasangwa, D; Marcantonio, ER; Mathur, P; Mueller, A; O'Gara, B; Packiasabapathy, S; Patxot, M; Shaefi, S; Shankar, P; Subramaniam, B; Talmor, D, 2019) |
| "Dexmedetomidine is associated with less delirium than benzodiazepines and better sleep architecture than either benzodiazepines or propofol; its effect on delirium and sleep when administered at night to patients requiring sedation remains unclear." | 9.27 | Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial. ( Devlin, JW; Duprey, MS; Hill, NS; Skrobik, Y, 2018) |
| " One patient in the propofol group developed delirium compared to zero in desflurane." | 9.24 | The effect of desflurane versus propofol anesthesia on postoperative delirium in elderly obese patients undergoing total knee replacement: A randomized, controlled, double-blinded clinical trial. ( Goodman, S; Huddleston, J; Lemmens, HJ; Maloney, W; Sommer, BR; Tanaka, P, 2017) |
| "The Basel ProDex Study is an investigator-initiated, one-institutional, two-centre randomised controlled clinical trial for the treatment of delirium with dexmedetomidine versus propofol in 316 critically ill patients suffering from hyperactive and mixed delirium." | 9.24 | Comparison of propofol and dexmedetomidine infused overnight to treat hyperactive and mixed ICU delirium: a protocol for the Basel ProDex clinical trial. ( Blum, A; Gantner, L; Hollinger, A; Ledergerber, K; Marsch, S; Rüegg, S; Siegemund, M; Steiner, LA; Sutter, R; von Felten, S; Zimmermann, S, 2017) |
| "To investigate the effect of the intraoperative wake-up test on sevoflurane-sufentanil anesthesia for adolescent idiopathic scoliosis (AIS) surgery." | 9.17 | Effect of the intraoperative wake-up test in sevoflurane-sufentanil combined anesthesia during adolescent idiopathic scoliosis surgery: a randomized study. ( Dong, FT; Ma, WQ; Wang, HM; Wei, HM; Yang, YL; Zhang, CH, 2013) |
| "Emergence delirium (ED) is a frequent postoperative complication in young children undergoing ENT procedures and it may be exacerbated by sevoflurane anesthesia whereas propofol maintenance has been suggested to decrease the incidence of ED." | 9.14 | Emergence delirium and postoperative pain in children undergoing adenotonsillectomy: a comparison of propofol vs sevoflurane anesthesia. ( Bruegger, D; Mehta, B; Nicklaus, P; Penn, E; Pieters, BJ; Weatherly, R, 2010) |
| "Dexmedetomidine reduced the duration but not the incidence of delirium after cardiac surgery with effective analgesia/sedation, less hypotension, less vasopressor requirement, and more bradycardia versus morphine regimen." | 9.14 | Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM Study). ( Bass, F; Campbell, M; Chen, J; Grant, P; Hammond, N; Shehabi, Y; Wolfenden, H, 2009) |
| "The subjects were 83 premedicated children aged 1 to 6 years who underwent surgical procedures with propofol (group P, n=41) or with halothane (group H, n=42) anesthesia." | 9.14 | Emergence agitation in children after propofol versus halothane anesthesia. ( Baftiu, N; Hasani, A; Ozgen, S, 2009) |
| " This, however, does not result in a reduced incidence of emergence delirium after sevoflurane anesthesia." | 9.12 | Midazolam does not reduce emergence delirium after sevoflurane anesthesia in children. ( Breschan, C; Jost, R; Likar, R; Platzer, M; Stettner, H, 2007) |
| " This study was designed to compare the effects of propofol and sevoflurane anesthesia on recovery characteristics and the incidence of post-operative delirium (POD) in long-duration laparoscopic surgery for elderly patients." | 9.11 | Recovery characteristics and post-operative delirium after long-duration laparoscope-assisted surgery in elderly patients: propofol-based vs. sevoflurane-based anesthesia. ( Nakayama, M; Namiki, A; Nishikawa, K; Omote, K, 2004) |
| "To assess if dexmedetomidine sedation is associated with a reduction in ICU delirium among older adults, and to evaluate its risks and benefits compared with propofol sedation." | 9.05 | Dexmedetomidine versus propofol sedation in reducing delirium among older adults in the ICU: A systematic review and meta-analysis. ( Arora, RC; Le, ML; Mohammed, MK; Pereira, JV; Sanjanwala, RM, 2020) |
| "Dexmedetomidine sedation could reduce postoperative delirium and was associated with shorter length of intubation, but might increase bradycardia in patients after cardiac surgery compared with propofol." | 8.95 | Dexmedetomidine vs propofol sedation reduces delirium in patients after cardiac surgery: A meta-analysis with trial sequential analysis of randomized controlled trials. ( Fang, X; Jin, Y; Liu, X; Song, F; Song, S; Xie, G; Zhang, K, 2017) |
| "Emergence delirium and agitation (EAD) associated with sevoflurane general anesthesia are very commonly observed in young children." | 8.89 | Prevention of sevoflurane delirium and agitation with propofol. ( Messieha, Z, 2013) |
| "At this time, there are no studies evaluating the risk of delirium or coma with the use of ketamine in mechanically ventilated adult patients, compared to conventional therapies such as propofol or dexmedetomidine." | 7.96 | Comparison of Ketamine- Versus Nonketamine-Based Sedation on Delirium and Coma in the Intensive Care Unit. ( Patanwala, AE; Radosevich, JJ; Shurtleff, V, 2020) |
| "Within the framework of this study the question arose whether the barbiturate methohexital could be associated with a lower incidence of delirium in comparison to midazolam or propofol in analgosedated and ventilated ICU patients." | 7.80 | [Methohexital for analgosedation of ventilated intensive care patients : prospective nonrandomized single center observational study on incidence of delirium]. ( Hopf, HB; Schütz, M; Vogt, A; Volz, D, 2014) |
| " Although delirium caused by midazolam or propofol in different patients has been reported, the present case represents a delirium that developed from both drugs in the same patient, possibly because of the patient's smaller tolerance to midazolam and propofol." | 7.73 | Delirium during intravenous sedation with midazolam alone and with propofol in dental treatment. ( Inada, H; Jinno, S; Kohase, H; Mohri-Ikuzawa, Y; Takahashi, N; Umino, M, 2006) |
| "Remimazolam tosylate is a novel, ultrashort-acting benzodiazepine, and there is limited evidence of its correlation with the incidence of early POD." | 7.30 | Comparison of the effects of remimazolam tosylate and propofol on postoperative delirium among older adults undergoing major non-cardiac surgery: protocol for a randomised controlled trial. ( Li, BL; Li, HX; Li, HY; Mu, B; Sun, YL; Wang, F; Wang, TH; Xu, X; Yan, T; Zhang, X; Zheng, H, 2023) |
| "Postoperative delirium is common in elderly cardiac surgery patients." | 6.87 | Dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium following cardiac surgery (DEXACET trial): protocol for a prospective randomized controlled trial. ( Gasangwa, D; Marcantonio, ER; Mueller, A; O'Gara, B; Packiasabapathy, S; Patxot, M; Shaefi, S; Shankar, P; Subramaniam, B, 2018) |
| "Emergence delirium is a common problem in children recovering from general anaesthesia." | 6.82 | A comparison of single dose dexmedetomidine with propofol for the prevention of emergence delirium after desflurane anaesthesia in children. ( Bala, I; Bhatia, N; Dwivedi, D; Makkar, JK; Singh, PM, 2016) |
| "Emergence delirium is a significant problem in children regaining consciousness following general anaesthesia." | 6.80 | A comparison of single-dose dexmedetomidine or propofol on the incidence of emergence delirium in children undergoing general anaesthesia for magnetic resonance imaging. ( Allen, JC; Bong, CL; Choo, WL; Lim, E; Siow, YN; Tan, JS; Teo, PB, 2015) |
| "Propofol has been shown to reduce ED, but these studies have been methodologically limited." | 6.78 | Emergence delirium in children: a randomized trial to compare total intravenous anesthesia with propofol and remifentanil to inhalational sevoflurane anesthesia. ( Ansermino, JM; Chandler, JR; Groberman, MK; Mehta, D; Montgomery, CJ; Myers, D; Whyte, E, 2013) |
| " The delirium incidence was lower in the dexmedetomidine group than in the propofol group (11 [3." | 5.69 | Postoperative Delirium after Dexmedetomidine versus Propofol Sedation in Healthy Older Adults Undergoing Orthopedic Lower Limb Surgery with Spinal Anesthesia: A Randomized Controlled Trial. ( Do, SH; Han, SH; Hwang, JW; Kim, H; Na, HS; Shin, HJ; Woo Nam, S; Yim, S, 2023) |
| "General anesthesia with remimazolam was not associated with an increased incidence of postoperative delirium compared with propofol in older adult patients undergoing orthopedic surgery." | 5.69 | Effect of Remimazolam on Postoperative Delirium in Older Adult Patients Undergoing Orthopedic Surgery: A Prospective Randomized Controlled Clinical Trial. ( Chen, S; Lei, L; Mao, YY; Qiu, D; Xing, LK; Yang, JJ; Zhao, JW, 2023) |
| "This study aimed to explore the effects of different injection rates of propofol on postoperative cognition in elderly patients undergoing laparoscopic inguinal hernia repair." | 5.69 | Effects of Different Injection Rates of Propofol on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Inguinal Hernia Repair. ( Han, W; He, L; Hu, L; Li, T; Liu, J; Peng, L; Wang, S; Wang, Y; Xia, M; Yang, X, 2023) |
| " Delirium occurred in the postoperative period in 25% of patients sedated with propofol, while in the dexmedetomidine group it was only 11." | 5.69 | Dexmedetomidine vs. propofol sedation reduces the duration of mechanical ventilation after cardiac surgery - a randomized controlled trial. ( Dračina, N; Drljević Todić, V; Kovač, A; Marković, N; Mladenović, N; Okiljević, B; Pantić, T; Preveden, A; Preveden, M; Tatić, M; Todić, M; Vicković, S; Vujić, V; Zdravković, R; Zec, R, 2023) |
| " Propofol-remifentanil anesthesia was guided either by SedLine (EEG-guided care, n=779) or not (usual care, n=781)." | 5.51 | Effect of Electroencephalography Spectral Edge Frequency (SEF) and Patient State Index (PSI)-Guided Propofol-Remifentanil Anesthesia on Delirium After Laparoscopic Surgery: The eMODIPOD Randomized Controlled Trial. ( Dai, F; Gelb, AW; Guo, Q; Li, L; Li, Q; Liu, H; Luo, H; Luo, N; Meng, L; Song, Z; Wang, E; Wang, L; Ye, C; Zhang, Y; Zhong, Y; Zhu, M; Zou, Y, 2022) |
| "The primary objective of this study is to compare the impact of propofol and sevoflurane on the incidence of postoperative delirium for elderly patients undergoing spine surgery." | 5.51 | Impact of propofol versus sevoflurane on the incidence of postoperative delirium in elderly patients after spine surgery: study protocol of a randomized controlled trial. ( Chen, TT; Gao, Y; Lv, M; Wan, TT; Wang, JH; Wang, YL; Zhang, HX, 2022) |
| "This study examined recovery, delirium, and neurocognitive outcome in elderly patients receiving dexmedetomidine or propofol sedation after undergoing cardiac surgery." | 5.51 | Dexmedetomidine Use in Intensive Care Unit Sedation and Postoperative Recovery in Elderly Patients Post-Cardiac Surgery (DIRECT). ( Bhalla, RK; Brohan, J; Chitnis, S; Grey, R; Klein, R; Mullane, D; Noronha, A; Paje, H; Sidhu, J, 2022) |
| "Propofol is a widely used anaesthetic drug with advantageous operating conditions and recovery profile." | 5.51 | A novel understanding of postoperative complications: In vitro study of the impact of propofol on epigenetic modifications in cholinergic genes. ( Adamzik, M; Bazzi, M; Bazzi, Z; Bergmann, L; Bukhari, H; Holtkamp, C; Koos, B; Rahmel, T; Rump, K; Unterberg, M, 2019) |
| "The consumption of propofol and remifentanil, postoperative hospital stay, postoperative pulmonary atelectasis, postoperative nausea/vomiting, and postoperative itchiness in the UG-TPVB group were lower than that in the PCA group." | 5.51 | Thoracic Paravertebral Block Ameliorates Postoperative Delirium in Geriatric Patients. ( Heng, L; Li, L; Wang, M; Zhu, S, 2022) |
| " The results showed that the dosage of sufentanil and propofol decreased significantly in the experimental group (P<0." | 5.48 | Effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery. ( Xie, M; Xie, S, 2018) |
| "The key objective of this study is to assess whether remimazolam besylate reduces the incidence of delirium in patients after cardiac surgery compared to propofol sedation." | 5.41 | Effect of remimazolam besylate compared with propofol on the incidence of delirium after cardiac surgery: study protocol for a randomized trial. ( Bai, Y; Dong, R; Liu, X; Qin, B; Song, X; Tian, S; Yang, D; Yang, M, 2021) |
| "Adding low-dose rate dexmedetomidine to a sedative regimen based on propofol did not result in a different risk of in-hospital delirium in older patients undergoing cardiac surgery." | 5.41 | Propofol plus low-dose dexmedetomidine infusion and postoperative delirium in older patients undergoing cardiac surgery. ( De Kerchove, L; Jacquet, LM; Kahn, D; Khalifa, C; Lemaire, G; Mastrobuoni, S; Momeni, M; Rosal Martins, M; Tircoveanu, R; Van Dyck, M; Watremez, C; Zango, SH, 2021) |
| "Propofol is a medication commonly used in anesthesiology practice and sedation in intubated patients." | 5.39 | Propofol and the risk of delirium: exploring the anticholinergic properties of propofol. ( Brown, KE; Kwatra, MM; Mirrakhimov, AE; Yeddula, K, 2013) |
| "We set up to determine the incidence and duration of postoperative delirium in older patients who had surgery under the intravenous anesthetic propofol or the inhalational anesthetic sevoflurane." | 5.34 | The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study. ( Li, C; Ma, X; Marcantonio, E; Mei, X; Shen, Y; Xie, Z; Zheng, H; Zheng, HL, 2020) |
| "Postictal delirium is an acute confusional state occurring during the immediate postictal phase in patients receiving electroconvulsive therapy that is characterized by motor agitation, disorientation, clouded consciousness, repetitive stereotyped movements, and poor response to commands." | 5.32 | Propofol in the management of postictal delirium with clozapine-electroconvulsive therapy combination. ( Bouckaert, F; Fernandez, I; Hagon, A; Hagon, B; Peuskens, J; Sienaert, P, 2004) |
| "To evaluate the effect of postoperative intravenous (IV) acetaminophen (paracetamol) vs placebo combined with IV propofol vs dexmedetomidine on postoperative delirium among older patients undergoing cardiac surgery." | 5.30 | Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial. ( Banner-Goodspeed, V; Eikermann, M; Gallagher, J; Gasangwa, D; Marcantonio, ER; Mathur, P; Mueller, A; O'Gara, B; Packiasabapathy, S; Patxot, M; Shaefi, S; Shankar, P; Subramaniam, B; Talmor, D, 2019) |
| " Sedation with dexmedetomidine may reduce postoperative delirium (POD)." | 5.27 | Intraoperative Sedation With Dexmedetomidine is Superior to Propofol for Elderly Patients Undergoing Hip Arthroplasty: A Prospective Randomized Controlled Study. ( Chen, S; Cheng, X; Gu, E; Liu, X; Mei, B; Meng, G; Xu, G; Zhang, M; Zhang, Y, 2018) |
| "Dexmedetomidine is associated with less delirium than benzodiazepines and better sleep architecture than either benzodiazepines or propofol; its effect on delirium and sleep when administered at night to patients requiring sedation remains unclear." | 5.27 | Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial. ( Devlin, JW; Duprey, MS; Hill, NS; Skrobik, Y, 2018) |
| " One patient in the propofol group developed delirium compared to zero in desflurane." | 5.24 | The effect of desflurane versus propofol anesthesia on postoperative delirium in elderly obese patients undergoing total knee replacement: A randomized, controlled, double-blinded clinical trial. ( Goodman, S; Huddleston, J; Lemmens, HJ; Maloney, W; Sommer, BR; Tanaka, P, 2017) |
| "To evaluate the effect of two anesthetic agents (sevoflurane or propofol) on postoperative delirium (POD) in patients undergoing off-pump coronary artery bypass grafting (CABG)." | 5.24 | Postoperative Delirium in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting According to the Anesthetic Agent: A Retrospective Study. ( Kang, WS; Kim, SH; Oh, CS; Park, S; Wan Hong, S; Yoon, TG, 2017) |
| "The Basel ProDex Study is an investigator-initiated, one-institutional, two-centre randomised controlled clinical trial for the treatment of delirium with dexmedetomidine versus propofol in 316 critically ill patients suffering from hyperactive and mixed delirium." | 5.24 | Comparison of propofol and dexmedetomidine infused overnight to treat hyperactive and mixed ICU delirium: a protocol for the Basel ProDex clinical trial. ( Blum, A; Gantner, L; Hollinger, A; Ledergerber, K; Marsch, S; Rüegg, S; Siegemund, M; Steiner, LA; Sutter, R; von Felten, S; Zimmermann, S, 2017) |
| "Dexmedetomidine did not significantly impact ICU length of stay compared with propofol, but it significantly reduced the duration of mechanical ventilation and the risk of delirium in cardiac surgical patients." | 5.22 | Outcomes of dexmedetomidine versus propofol sedation in critically ill adults requiring mechanical ventilation: a systematic review and meta-analysis of randomised controlled trials. ( Ali, S; Deng, J; Heybati, K; Mohananey, D; Ramakrishna, H; Villablanca, P; Zhou, F, 2022) |
| "To investigate the effect of the intraoperative wake-up test on sevoflurane-sufentanil anesthesia for adolescent idiopathic scoliosis (AIS) surgery." | 5.17 | Effect of the intraoperative wake-up test in sevoflurane-sufentanil combined anesthesia during adolescent idiopathic scoliosis surgery: a randomized study. ( Dong, FT; Ma, WQ; Wang, HM; Wei, HM; Yang, YL; Zhang, CH, 2013) |
| " Sevoflurane was reliable during the MRI, but emergence delirium was a concern." | 5.17 | Propofol-remifentanil or sevoflurane for children undergoing magnetic resonance imaging? A randomised study. ( Jensen, AG; Kilmose, L; Olsen, KS; Pedersen, NA, 2013) |
| "Emergence delirium (ED) is a frequent postoperative complication in young children undergoing ENT procedures and it may be exacerbated by sevoflurane anesthesia whereas propofol maintenance has been suggested to decrease the incidence of ED." | 5.14 | Emergence delirium and postoperative pain in children undergoing adenotonsillectomy: a comparison of propofol vs sevoflurane anesthesia. ( Bruegger, D; Mehta, B; Nicklaus, P; Penn, E; Pieters, BJ; Weatherly, R, 2010) |
| "We performed a double-blind, randomized controlled trial at an academic medical center of elderly patients (>or=65 years) without preoperative delirium or severe dementia who underwent hip fracture repair under spinal anesthesia with propofol sedation." | 5.14 | Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair. ( Blute, MR; Gottschalk, A; Lee, HB; Mears, SC; Rosenberg, PB; Sieber, FE; Zakriya, KJ, 2010) |
| "Dexmedetomidine reduced the duration but not the incidence of delirium after cardiac surgery with effective analgesia/sedation, less hypotension, less vasopressor requirement, and more bradycardia versus morphine regimen." | 5.14 | Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM Study). ( Bass, F; Campbell, M; Chen, J; Grant, P; Hammond, N; Shehabi, Y; Wolfenden, H, 2009) |
| " Volatile anesthetics have been associated with emergence delirium in children, whereas the use of propofol for anesthetic maintenance has been shown to reduce the incidence of emergence delirium after other types of surgeries." | 5.14 | Quality of recovery from two types of general anesthesia for ambulatory dental surgery in children: a double-blind, randomized trial. ( Barclay, S; Brennen, KA; Ellis, J; Gorman, K; König, MW; Nick, TG; Samuels, PJ; Shackleford, TM; Varughese, AM; Wang, Y, 2009) |
| "The subjects were 83 premedicated children aged 1 to 6 years who underwent surgical procedures with propofol (group P, n=41) or with halothane (group H, n=42) anesthesia." | 5.14 | Emergence agitation in children after propofol versus halothane anesthesia. ( Baftiu, N; Hasani, A; Ozgen, S, 2009) |
| " This, however, does not result in a reduced incidence of emergence delirium after sevoflurane anesthesia." | 5.12 | Midazolam does not reduce emergence delirium after sevoflurane anesthesia in children. ( Breschan, C; Jost, R; Likar, R; Platzer, M; Stettner, H, 2007) |
| " This study was designed to compare the effects of propofol and sevoflurane anesthesia on recovery characteristics and the incidence of post-operative delirium (POD) in long-duration laparoscopic surgery for elderly patients." | 5.11 | Recovery characteristics and post-operative delirium after long-duration laparoscope-assisted surgery in elderly patients: propofol-based vs. sevoflurane-based anesthesia. ( Nakayama, M; Namiki, A; Nishikawa, K; Omote, K, 2004) |
| "To assess if dexmedetomidine sedation is associated with a reduction in ICU delirium among older adults, and to evaluate its risks and benefits compared with propofol sedation." | 5.05 | Dexmedetomidine versus propofol sedation in reducing delirium among older adults in the ICU: A systematic review and meta-analysis. ( Arora, RC; Le, ML; Mohammed, MK; Pereira, JV; Sanjanwala, RM, 2020) |
| "We are uncertain whether maintenance with propofol-based TIVA or with inhalational agents affect incidences of postoperative delirium, mortality, or length of hospital stay because certainty of the evidence was very low." | 4.98 | Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery. ( Alderson, P; Lewis, SR; Miller, D; Pritchard, MW; Schofield-Robinson, OJ; Shelton, CL; Smith, AF, 2018) |
| "Dexmedetomidine sedation could reduce postoperative delirium and was associated with shorter length of intubation, but might increase bradycardia in patients after cardiac surgery compared with propofol." | 4.95 | Dexmedetomidine vs propofol sedation reduces delirium in patients after cardiac surgery: A meta-analysis with trial sequential analysis of randomized controlled trials. ( Fang, X; Jin, Y; Liu, X; Song, F; Song, S; Xie, G; Zhang, K, 2017) |
| "Emergence delirium and agitation (EAD) associated with sevoflurane general anesthesia are very commonly observed in young children." | 4.89 | Prevention of sevoflurane delirium and agitation with propofol. ( Messieha, Z, 2013) |
| "To evaluate whether different gamma-aminobutyric acidergic (GABAergic) sedatives such as propofol and benzodiazepines carry differential risks of post-extubation delirium in the ICU." | 4.12 | Differential Effects of Gamma-Aminobutyric Acidergic Sedatives on Risk of Post-Extubation Delirium in the ICU: A Retrospective Cohort Study From a New England Health Care Network. ( Ahn, C; Azimaraghi, O; Eikermann, M; Kiyatkin, ME; Rumyantsev, S; Santer, P; Sarge, T; Subramaniam, B; Teja, B; Wachtendorf, LJ; Wongtangman, K, 2022) |
| " This case report describes the successful use of propofol, an ultra-fast-acting anaesthetic agent commonly used for anaesthesia induction and maintenance to manage refractory agitated delirium in an acute inpatient palliative medicine setting." | 3.96 | Propofol for palliative sedation. ( Michael, NG; Sulistio, M; Wojnar, R, 2020) |
| "At this time, there are no studies evaluating the risk of delirium or coma with the use of ketamine in mechanically ventilated adult patients, compared to conventional therapies such as propofol or dexmedetomidine." | 3.96 | Comparison of Ketamine- Versus Nonketamine-Based Sedation on Delirium and Coma in the Intensive Care Unit. ( Patanwala, AE; Radosevich, JJ; Shurtleff, V, 2020) |
| " Late awakening was more frequent with midazolam (58% vs 45%) and was associated with higher rates of delirium (62% vs 39%) and unfavorable 3-months outcome (27% vs 12%; all p = 0." | 3.91 | Late Awakening in Survivors of Postanoxic Coma: Early Neurophysiologic Predictors and Association With ICU and Long-Term Neurologic Recovery. ( Eckert, P; Miroz, JP; Oddo, M; Rey, A; Rossetti, AO, 2019) |
| " Fentanyl (77%) and hydromorphone (48%) were the most common intravenous opioids used to manage pain." | 3.91 | Current practice and perceptions regarding pain, agitation and delirium management in patients receiving venovenous extracorporeal membrane oxygenation. ( Abrams, D; Agerstrand, C; Brodie, D; Dzierba, AL; Madahar, P; Muir, J, 2019) |
| "Within the framework of this study the question arose whether the barbiturate methohexital could be associated with a lower incidence of delirium in comparison to midazolam or propofol in analgosedated and ventilated ICU patients." | 3.80 | [Methohexital for analgosedation of ventilated intensive care patients : prospective nonrandomized single center observational study on incidence of delirium]. ( Hopf, HB; Schütz, M; Vogt, A; Volz, D, 2014) |
| "To determine whether benzodiazepine and propofol doses are increased at night and whether daytime and nighttime sedative doses are associated with delirium, coma, and delayed liberation from mechanical ventilation." | 3.78 | Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium. ( Ely, EW; Girard, TD; Hudson, LD; Koestner, T; Pandharipande, PP; Seymour, CW; Shintani, AK; Thompson, JL, 2012) |
| "Propofol anesthesia decreases postoperative delirium in elderly patients compared with sevoflurane anesthesia." | 3.77 | [Influence of general anesthetics on the incidence of postoperative delirium in the elderly]. ( Akiyama, D; Hara, K; Ishii, K; Makita, T; Sumikawa, K, 2011) |
| " Although delirium caused by midazolam or propofol in different patients has been reported, the present case represents a delirium that developed from both drugs in the same patient, possibly because of the patient's smaller tolerance to midazolam and propofol." | 3.73 | Delirium during intravenous sedation with midazolam alone and with propofol in dental treatment. ( Inada, H; Jinno, S; Kohase, H; Mohri-Ikuzawa, Y; Takahashi, N; Umino, M, 2006) |
| "Remimazolam tosylate is a novel, ultrashort-acting benzodiazepine, and there is limited evidence of its correlation with the incidence of early POD." | 3.30 | Comparison of the effects of remimazolam tosylate and propofol on postoperative delirium among older adults undergoing major non-cardiac surgery: protocol for a randomised controlled trial. ( Li, BL; Li, HX; Li, HY; Mu, B; Sun, YL; Wang, F; Wang, TH; Xu, X; Yan, T; Zhang, X; Zheng, H, 2023) |
| "The rates of respiratory depression (1." | 3.11 | Effect of additional equipotent fentanyl or sufentanil administration on recovery profiles during propofol-remifentanil-based anaesthesia in patients undergoing gynaecologic laparoscopic surgery: a randomized clinical trial. ( Huang, D; Huang, J; Jian, Q; Li, P; Ma, J; Xie, H; Zeng, W; Zhang, C, 2022) |
| "Postoperative delirium is the most common complication following major surgery in older patients." | 2.87 | Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium: The STRIDE Randomized Clinical Trial. ( Bigelow, GE; Gottschalk, A; Hasenboehler, EA; Jaberi, M; Li, T; Mears, SC; Neufeld, KJ; Oh, ES; Ouanes, JP; Rosenberg, PB; Sieber, FE; Stewart, KJ; Wang, NY, 2018) |
| "Postoperative delirium is common in elderly cardiac surgery patients." | 2.87 | Dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium following cardiac surgery (DEXACET trial): protocol for a prospective randomized controlled trial. ( Gasangwa, D; Marcantonio, ER; Mueller, A; O'Gara, B; Packiasabapathy, S; Patxot, M; Shaefi, S; Shankar, P; Subramaniam, B, 2018) |
| "Elderly patients who have solid organ cancer often receive surgery." | 2.84 | Impact of inhalational versus intravenous anaesthesia on early delirium and long-term survival in elderly patients after cancer surgery: study protocol of a multicentre, open-label, and randomised controlled trial. ( Ai, YQ; Guo, YQ; Jia, HQ; Jia, Z; Li, HJ; Liu, ZH; Ma, D; Ouyang, W; Pan, LH; Sun, XD; Tan, HY; Wang, DX; Yang, XD; Ye, QS; Yin, N; Yu, JB; Zhang, FX; Zhang, QG; Zhang, Y; Zhao, BJ, 2017) |
| " (4) Compared with control group with the same sedative, the duration of mechanical ventilation, extubation time, length of ICU stay were significantly shortened, and the dosage of sedative drugs used was reduced in study group (all P < 0." | 2.82 | [Study of prevention and control of delirium in ventilated patients by simulating blockage of circadian rhythm with sedative in intensive care unit]. ( Dong, C; Feng, F; Li, J; Qi, Y; Song, R; Yang, J; Yang, Z; Zhang, H, 2016) |
| "Emergence delirium is a common problem in children recovering from general anaesthesia." | 2.82 | A comparison of single dose dexmedetomidine with propofol for the prevention of emergence delirium after desflurane anaesthesia in children. ( Bala, I; Bhatia, N; Dwivedi, D; Makkar, JK; Singh, PM, 2016) |
| "Emergence delirium is a significant problem in children regaining consciousness following general anaesthesia." | 2.80 | A comparison of single-dose dexmedetomidine or propofol on the incidence of emergence delirium in children undergoing general anaesthesia for magnetic resonance imaging. ( Allen, JC; Bong, CL; Choo, WL; Lim, E; Siow, YN; Tan, JS; Teo, PB, 2015) |
| "And propofol was used for rescue." | 2.79 | [Sedative effects of dexmedetomidine in post-operative elder patients on mechanical ventilation]. ( Huang, F; Jin, J; Kong, J; Liu, S; Wang, J; Xu, H; Yang, X, 2014) |
| "Propofol was given to 16 of 21 (76%) of early goal-directed sedation versus 16 of 16 (100%) of standard sedation patients (p = 0." | 2.78 | Early goal-directed sedation versus standard sedation in mechanically ventilated critically ill patients: a pilot study*. ( Bailey, M; Bass, F; Bellomo, R; Howe, B; McArthur, C; Murray, L; Reade, MC; Seppelt, IM; Shehabi, Y; Webb, S; Weisbrodt, L, 2013) |
| "Propofol has been shown to reduce ED, but these studies have been methodologically limited." | 2.78 | Emergence delirium in children: a randomized trial to compare total intravenous anesthesia with propofol and remifentanil to inhalational sevoflurane anesthesia. ( Ansermino, JM; Chandler, JR; Groberman, MK; Mehta, D; Montgomery, CJ; Myers, D; Whyte, E, 2013) |
| "The propofol group was administered propofol 4 mg/kg i." | 2.73 | Open-label, prospective, randomized comparison of propofol and sevoflurane for laryngeal mask anesthesia for magnetic resonance imaging in pediatric patients. ( Egilmez, H; Gursoy, S; Kaygusuz, K; Kol, IO; Mimaroglu, C, 2008) |
| "Remifentanil hydrochloride is an ultra-short acting m-opioid receptor agonist." | 2.72 | Remifentanil vs fentanyl with a target controlled propofol infusion in patients undergoing craniotomy for supratentorial lesions. ( Ciritella, P; De Vivo, P; Del Gaudio, A; Lauta, E; Mastronardi, P; Perrotta, F; Puopolo, M, 2006) |
| "Patients in the ICU after long-term administration of an opioid/hypnotic often develop delirium." | 2.71 | Withdrawal following sufentanil/propofol and sufentanil/midazolam. Sedation in surgical ICU patients: correlation with central nervous parameters and endogenous opioids. ( Freye, EC; Korak-Leiter, M; Levy, JV; Likar, R; Oher, M; Trampitsch, E; Ziervogel, G, 2005) |
| "Propofol is an oil at room temperature and insoluble in aqueous solution." | 2.42 | Propofol: therapeutic indications and side-effects. ( Marik, PE, 2004) |
| " The dose-response relationship between burst suppression, total time spent in maximal burst suppression, and their association with delirium warrants further evaluation." | 1.72 | Inadvertent Burst Suppression During Total Intravenous Anesthesia in 112 Consecutive Patients Undergoing Spinal Instrumentation Surgery: A Retrospective Observational Quality Improvement Project. ( Furman, M; Hecker, J; Kinney, G; Lele, AV; Myers, J; Sharma, D, 2022) |
| "To determine if adjunctive use of quetiapine reduces sedative dosage requirements among mechanically ventilated adults without delirium." | 1.62 | Effectiveness of Quetiapine as a Sedative Adjunct in Mechanically Ventilated Adults Without Delirium. ( Cox, CE; Gilstrap, DL; Kram, BL; Kram, SJ; Ohman, KL; Schultheis, JM; Yang, Z, 2021) |
| "Propofol and fentanyl were the sedative agents of choice in the early and late periods, respectively." | 1.56 | Singapore SPICE: sedation practices in intensive care evaluation in Singapore - a prospective cohort study of the public healthcare system. ( Bailey, MJ; Chia, N; Ho, BCH; Kalyanasundaram, G; Lim, D; Mukhopadhyay, A; Ng, SY; Phua, J; Shehabi, Y; Ti, LK; Wong, YL, 2020) |
| "Baclofen and diazepam were introduced on the third day, allowing dose reductions in anaesthetic agents the fourth day and extubation on the fifth day with resolution of the delirium." | 1.56 | Severe delirium after GHB abuse. ( Giil, LM; Sundal, EV, 2020) |
| "Delirium is a common neurocognitive complication in cancer." | 1.51 | Trajectory of severity of postoperative delirium symptoms and its prospective association with cognitive function in patients with gastric cancer: results from a prospective observational study. ( Hahm, BJ; Hwang, H; Jung, D; Kim, WH; Kong, SH; Lee, HJ; Lee, KM; Noh, HL; Shim, EJ; Son, KL; Suh, YS; Yang, HK, 2019) |
| "Propofol is a widely used anaesthetic drug with advantageous operating conditions and recovery profile." | 1.51 | A novel understanding of postoperative complications: In vitro study of the impact of propofol on epigenetic modifications in cholinergic genes. ( Adamzik, M; Bazzi, M; Bazzi, Z; Bergmann, L; Bukhari, H; Holtkamp, C; Koos, B; Rahmel, T; Rump, K; Unterberg, M, 2019) |
| " The results showed that the dosage of sufentanil and propofol decreased significantly in the experimental group (P<0." | 1.48 | Effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery. ( Xie, M; Xie, S, 2018) |
| "Delirium was the most frequent reason for PS (n = 15, 75%)." | 1.46 | Bispectral Index monitoring in cancer patients undergoing palliative sedation: a preliminary report. ( Allende-Pérez, S; Bruera, E; García-Salamanca, MF; Hui, D; Monreal-Carrillo, E; Verástegui, E, 2017) |
| "Propofol (89%) use was common, followed by midazolam (49%)." | 1.42 | A web-based survey of United Kingdom sedation practice in the intensive care unit. ( McKenzie, CA; Terblanche, M; Yassin, J; Yassin, SM, 2015) |
| "Postoperative delirium is a recognized complication in populations at risk." | 1.40 | Incidence of postoperative delirium is high even in a population without known risk factors. ( Saporito, A; Sturini, E, 2014) |
| "Propofol is a medication commonly used in anesthesiology practice and sedation in intubated patients." | 1.39 | Propofol and the risk of delirium: exploring the anticholinergic properties of propofol. ( Brown, KE; Kwatra, MM; Mirrakhimov, AE; Yeddula, K, 2013) |
| "Postictal delirium is an acute confusional state occurring during the immediate postictal phase in patients receiving electroconvulsive therapy that is characterized by motor agitation, disorientation, clouded consciousness, repetitive stereotyped movements, and poor response to commands." | 1.32 | Propofol in the management of postictal delirium with clozapine-electroconvulsive therapy combination. ( Bouckaert, F; Fernandez, I; Hagon, A; Hagon, B; Peuskens, J; Sienaert, P, 2004) |
| "Propofol seems to be a promising drug in treating the terminal agitated state that can be associated with the dying process." | 1.29 | Propofol in terminal care. ( De Conno, F; Mercadante, S; Ripamonti, C, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (2.34) | 18.2507 |
| 2000's | 22 (17.19) | 29.6817 |
| 2010's | 66 (51.56) | 24.3611 |
| 2020's | 37 (28.91) | 2.80 |
| Authors | Studies |
|---|---|
| Heng, L | 1 |
| Wang, M | 2 |
| Li, L | 2 |
| Zhu, S | 1 |
| Yang, M | 1 |
| Liu, X | 3 |
| Yang, D | 1 |
| Bai, Y | 1 |
| Qin, B | 1 |
| Tian, S | 1 |
| Dong, R | 1 |
| Song, X | 1 |
| Wang, E | 1 |
| Wang, L | 1 |
| Ye, C | 1 |
| Luo, N | 1 |
| Zhang, Y | 3 |
| Zhong, Y | 1 |
| Zhu, M | 1 |
| Zou, Y | 1 |
| Li, Q | 1 |
| Song, Z | 1 |
| Luo, H | 1 |
| Dai, F | 1 |
| Liu, H | 1 |
| Gelb, AW | 1 |
| Guo, Q | 1 |
| Meng, L | 1 |
| Chitnis, S | 1 |
| Mullane, D | 1 |
| Brohan, J | 1 |
| Noronha, A | 1 |
| Paje, H | 1 |
| Grey, R | 1 |
| Bhalla, RK | 1 |
| Sidhu, J | 1 |
| Klein, R | 1 |
| Azimaraghi, O | 1 |
| Wongtangman, K | 1 |
| Wachtendorf, LJ | 1 |
| Santer, P | 1 |
| Rumyantsev, S | 1 |
| Ahn, C | 1 |
| Kiyatkin, ME | 1 |
| Teja, B | 1 |
| Sarge, T | 1 |
| Subramaniam, B | 4 |
| Eikermann, M | 2 |
| Zhang, C | 1 |
| Huang, D | 1 |
| Zeng, W | 1 |
| Ma, J | 2 |
| Li, P | 1 |
| Jian, Q | 1 |
| Huang, J | 1 |
| Xie, H | 1 |
| Gruber, BU | 1 |
| Girsberger, V | 1 |
| Kusstatscher, L | 1 |
| Funk, S | 1 |
| Luethy, A | 1 |
| Jakus, L | 1 |
| Maillard, J | 1 |
| Steiner, LA | 2 |
| Dell-Kuster, S | 1 |
| Burkhart, CS | 1 |
| Ding, L | 1 |
| Ning, J | 1 |
| Guo, Y | 1 |
| Wang, Q | 1 |
| Kou, S | 1 |
| Ke, H | 1 |
| Zhou, R | 1 |
| Yu, B | 1 |
| Heybati, K | 3 |
| Zhou, F | 2 |
| Ali, S | 2 |
| Deng, J | 3 |
| Mohananey, D | 1 |
| Villablanca, P | 1 |
| Ramakrishna, H | 1 |
| Wang, JH | 1 |
| Lv, M | 1 |
| Zhang, HX | 1 |
| Gao, Y | 1 |
| Chen, TT | 1 |
| Wan, TT | 1 |
| Wang, YL | 1 |
| Yoshimura, M | 1 |
| Shiramoto, H | 1 |
| Morimoto, Y | 1 |
| Koga, M | 1 |
| Duan, GY | 1 |
| Duan, ZX | 1 |
| Chen, H | 1 |
| Chen, F | 2 |
| Du, ZY | 1 |
| Chen, LY | 1 |
| Lu, KZ | 1 |
| Zuo, ZY | 1 |
| Li, H | 1 |
| Shin, HJ | 1 |
| Woo Nam, S | 1 |
| Kim, H | 1 |
| Yim, S | 1 |
| Han, SH | 1 |
| Hwang, JW | 1 |
| Do, SH | 1 |
| Na, HS | 1 |
| Aoki, Y | 1 |
| Suzuki, Y | 1 |
| Nakajima, Y | 1 |
| Yang, JJ | 2 |
| Lei, L | 1 |
| Qiu, D | 1 |
| Chen, S | 2 |
| Xing, LK | 1 |
| Zhao, JW | 1 |
| Mao, YY | 1 |
| Li, HX | 1 |
| Li, BL | 1 |
| Wang, TH | 1 |
| Xu, X | 1 |
| Wang, F | 1 |
| Zhang, X | 2 |
| Li, HY | 1 |
| Mu, B | 1 |
| Sun, YL | 1 |
| Zheng, H | 2 |
| Yan, T | 1 |
| Li, T | 3 |
| Han, W | 1 |
| Yang, X | 2 |
| Wang, Y | 2 |
| Peng, L | 1 |
| He, L | 1 |
| Hu, L | 1 |
| Liu, J | 1 |
| Xia, M | 1 |
| Wang, S | 1 |
| Coeckelenbergh, S | 1 |
| Soucy-Proulx, M | 1 |
| Radtke, FM | 1 |
| Dragovic, S | 1 |
| Schneider, G | 1 |
| García, PS | 1 |
| Hinzmann, D | 1 |
| Sleigh, J | 1 |
| Kratzer, S | 1 |
| Kreuzer, M | 1 |
| Huang, YQ | 1 |
| Weiss, S | 1 |
| Gros, P | 1 |
| Wong, E | 1 |
| Piché, PP | 1 |
| Vyas, MV | 1 |
| Tam, AKH | 1 |
| Watt, JA | 1 |
| Preveden, M | 1 |
| Zdravković, R | 1 |
| Vicković, S | 1 |
| Vujić, V | 1 |
| Todić, M | 1 |
| Mladenović, N | 1 |
| Dračina, N | 1 |
| Drljević Todić, V | 1 |
| Pantić, T | 1 |
| Okiljević, B | 1 |
| Marković, N | 1 |
| Kovač, A | 1 |
| Zec, R | 1 |
| Preveden, A | 1 |
| Tatić, M | 1 |
| Sun, Z | 1 |
| Sui, J | 1 |
| Sulistio, M | 1 |
| Wojnar, R | 1 |
| Michael, NG | 1 |
| Pereira, JV | 1 |
| Sanjanwala, RM | 1 |
| Mohammed, MK | 1 |
| Le, ML | 1 |
| Arora, RC | 1 |
| Mulkey, MA | 1 |
| Everhart, DE | 1 |
| Sundal, EV | 1 |
| Giil, LM | 1 |
| Olsen, HT | 1 |
| Nedergaard, HK | 1 |
| Strøm, T | 1 |
| Oxlund, J | 1 |
| Wian, KA | 1 |
| Ytrebø, LM | 1 |
| Kroken, BA | 1 |
| Chew, M | 1 |
| Korkmaz, S | 1 |
| Lauridsen, JT | 1 |
| Toft, P | 1 |
| Bastos, AS | 1 |
| Beccaria, LM | 1 |
| Silva, DCD | 1 |
| Barbosa, TP | 1 |
| Payen, JF | 1 |
| Chanques, G | 1 |
| Futier, E | 1 |
| Velly, L | 1 |
| Jaber, S | 1 |
| Constantin, JM | 1 |
| Mei, X | 1 |
| Zheng, HL | 1 |
| Li, C | 1 |
| Ma, X | 1 |
| Marcantonio, E | 1 |
| Xie, Z | 1 |
| Shen, Y | 1 |
| Ohman, KL | 1 |
| Schultheis, JM | 1 |
| Kram, SJ | 1 |
| Cox, CE | 1 |
| Gilstrap, DL | 1 |
| Yang, Z | 2 |
| Kram, BL | 1 |
| Momeni, M | 1 |
| Khalifa, C | 1 |
| Lemaire, G | 1 |
| Watremez, C | 1 |
| Tircoveanu, R | 1 |
| Van Dyck, M | 1 |
| Kahn, D | 1 |
| Rosal Martins, M | 1 |
| Mastrobuoni, S | 1 |
| De Kerchove, L | 1 |
| Zango, SH | 1 |
| Jacquet, LM | 1 |
| Lele, AV | 1 |
| Furman, M | 1 |
| Myers, J | 1 |
| Kinney, G | 1 |
| Sharma, D | 1 |
| Hecker, J | 1 |
| Monreal-Carrillo, E | 1 |
| Allende-Pérez, S | 1 |
| Hui, D | 1 |
| García-Salamanca, MF | 1 |
| Bruera, E | 1 |
| Verástegui, E | 1 |
| Tanaka, P | 1 |
| Goodman, S | 1 |
| Sommer, BR | 1 |
| Maloney, W | 1 |
| Huddleston, J | 1 |
| Lemmens, HJ | 1 |
| Oh, CS | 1 |
| Park, S | 1 |
| Wan Hong, S | 1 |
| Kang, WS | 1 |
| Yoon, TG | 1 |
| Kim, SH | 1 |
| Hollinger, A | 1 |
| Ledergerber, K | 1 |
| von Felten, S | 1 |
| Sutter, R | 1 |
| Rüegg, S | 1 |
| Gantner, L | 1 |
| Zimmermann, S | 1 |
| Blum, A | 1 |
| Marsch, S | 1 |
| Siegemund, M | 1 |
| Li, HJ | 1 |
| Wang, DX | 1 |
| Jia, HQ | 1 |
| Sun, XD | 1 |
| Pan, LH | 1 |
| Ye, QS | 1 |
| Ouyang, W | 1 |
| Jia, Z | 1 |
| Zhang, FX | 1 |
| Guo, YQ | 1 |
| Ai, YQ | 1 |
| Zhao, BJ | 1 |
| Yang, XD | 1 |
| Zhang, QG | 1 |
| Yin, N | 1 |
| Tan, HY | 1 |
| Liu, ZH | 1 |
| Yu, JB | 1 |
| Ma, D | 1 |
| Schmitz, A | 1 |
| Weiss, M | 1 |
| Kellenberger, C | 1 |
| O'Gorman Tuura, R | 1 |
| Klaghofer, R | 1 |
| Scheer, I | 1 |
| Makki, M | 1 |
| Sabandal, C | 1 |
| Buehler, PK | 1 |
| Skrobik, Y | 1 |
| Duprey, MS | 1 |
| Hill, NS | 1 |
| Devlin, JW | 1 |
| Nunes, SL | 1 |
| Forsberg, S | 1 |
| Blomqvist, H | 1 |
| Berggren, L | 1 |
| Sörberg, M | 1 |
| Sarapohja, T | 1 |
| Wickerts, CJ | 1 |
| Mei, B | 1 |
| Meng, G | 1 |
| Xu, G | 1 |
| Cheng, X | 1 |
| Zhang, M | 1 |
| Gu, E | 1 |
| Shurtleff, V | 1 |
| Radosevich, JJ | 1 |
| Patanwala, AE | 1 |
| Shankar, P | 3 |
| Mueller, A | 3 |
| Packiasabapathy, S | 2 |
| Gasangwa, D | 2 |
| Patxot, M | 2 |
| O'Gara, B | 2 |
| Shaefi, S | 2 |
| Marcantonio, ER | 2 |
| Whitlock, EL | 1 |
| Finlayson, E | 1 |
| Sieber, FE | 2 |
| Neufeld, KJ | 1 |
| Gottschalk, A | 2 |
| Bigelow, GE | 1 |
| Oh, ES | 1 |
| Rosenberg, PB | 2 |
| Mears, SC | 2 |
| Stewart, KJ | 1 |
| Ouanes, JP | 1 |
| Jaberi, M | 1 |
| Hasenboehler, EA | 1 |
| Wang, NY | 1 |
| Miller, D | 1 |
| Lewis, SR | 1 |
| Pritchard, MW | 1 |
| Schofield-Robinson, OJ | 1 |
| Shelton, CL | 1 |
| Alderson, P | 1 |
| Smith, AF | 1 |
| Rey, A | 1 |
| Rossetti, AO | 1 |
| Miroz, JP | 1 |
| Eckert, P | 1 |
| Oddo, M | 1 |
| Xie, S | 1 |
| Xie, M | 1 |
| Shim, EJ | 1 |
| Noh, HL | 1 |
| Lee, KM | 1 |
| Hwang, H | 1 |
| Son, KL | 1 |
| Jung, D | 1 |
| Kim, WH | 1 |
| Kong, SH | 1 |
| Suh, YS | 1 |
| Lee, HJ | 1 |
| Yang, HK | 1 |
| Hahm, BJ | 1 |
| Banner-Goodspeed, V | 1 |
| Gallagher, J | 1 |
| Mathur, P | 1 |
| Talmor, D | 1 |
| Shi, C | 1 |
| Jin, J | 2 |
| Qiao, L | 1 |
| Ma, Z | 1 |
| Holtkamp, C | 1 |
| Koos, B | 1 |
| Unterberg, M | 1 |
| Rahmel, T | 1 |
| Bergmann, L | 1 |
| Bazzi, Z | 1 |
| Bazzi, M | 1 |
| Bukhari, H | 1 |
| Adamzik, M | 1 |
| Rump, K | 1 |
| Ng, SY | 1 |
| Phua, J | 1 |
| Wong, YL | 1 |
| Kalyanasundaram, G | 1 |
| Mukhopadhyay, A | 1 |
| Lim, D | 1 |
| Chia, N | 1 |
| Ho, BCH | 1 |
| Bailey, MJ | 1 |
| Shehabi, Y | 3 |
| Ti, LK | 1 |
| Dzierba, AL | 1 |
| Abrams, D | 1 |
| Madahar, P | 1 |
| Muir, J | 1 |
| Agerstrand, C | 1 |
| Brodie, D | 1 |
| Wanek, MR | 1 |
| Chandler, JR | 1 |
| Myers, D | 1 |
| Mehta, D | 1 |
| Whyte, E | 1 |
| Groberman, MK | 1 |
| Montgomery, CJ | 1 |
| Ansermino, JM | 1 |
| Zhang, CH | 1 |
| Ma, WQ | 1 |
| Yang, YL | 1 |
| Dong, FT | 1 |
| Wang, HM | 1 |
| Wei, HM | 1 |
| Messieha, Z | 1 |
| Pedersen, NA | 1 |
| Jensen, AG | 1 |
| Kilmose, L | 1 |
| Olsen, KS | 1 |
| Bellomo, R | 1 |
| Reade, MC | 1 |
| Bailey, M | 1 |
| Bass, F | 2 |
| Howe, B | 1 |
| McArthur, C | 1 |
| Murray, L | 1 |
| Seppelt, IM | 1 |
| Webb, S | 1 |
| Weisbrodt, L | 1 |
| Brown, KE | 1 |
| Mirrakhimov, AE | 1 |
| Yeddula, K | 1 |
| Kwatra, MM | 1 |
| Saporito, A | 1 |
| Sturini, E | 1 |
| Carabaño Aguado, I | 1 |
| Herrero Álvarez, M | 1 |
| Alvarez García, R | 1 |
| Ayala Ortega, JL | 1 |
| Patel, SB | 2 |
| Poston, JT | 1 |
| Pohlman, A | 1 |
| Hall, JB | 2 |
| Kress, JP | 2 |
| Takala, J | 2 |
| Volz, D | 1 |
| Vogt, A | 1 |
| Schütz, M | 1 |
| Hopf, HB | 1 |
| Ely, EW | 2 |
| Pandharipande, PP | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Recovery From Propofol Anaesthesia Guided by Frontal EEG Wave Analysis Compared to Bispectral Index Monitoring Alone in Laparoscopic Surgery: A Multicentre Double-blind Randomised Controlled Trial[NCT04105660] | 232 participants (Actual) | Interventional | 2021-07-01 | Completed | |||
| Impact of Propofol Versus Sevoflurane on Incidence of Postoperative Delirium in Elderly Patients After Spine Surgery: a Randomized Controlled Trial[NCT05158998] | Phase 4 | 298 participants (Anticipated) | Interventional | 2022-03-21 | Recruiting | ||
| Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventilation. The NONSEDA-trial. An Investigator-initiated, Randomised, Clinical, Parallel-group, Multinational, Superiority Trial[NCT01967680] | 700 participants (Actual) | Interventional | 2014-01-31 | Completed | |||
| Does LOW Dose DEXmedetomidine After Cardiopulmonary Bypass Separation Decrease the Incidence of DELirium: A Double-blind Randomized Placebo-controlled Study (LOWDEXDEL Study)[NCT03388541] | Phase 4 | 420 participants (Actual) | Interventional | 2018-01-17 | Completed | ||
| Comparison of Propofol and Dexmedetomidine to Treat Hyperactive and Mixed ICU Delirium - the Basel ProDex Randomized Trial[NCT02807467] | Phase 4 | 37 participants (Actual) | Interventional | 2019-03-01 | Terminated (stopped due to insufficient recruitment over a long period) | ||
| Impact of Inhalational Versus Intravenous Anesthesia Maintenance Methods on Long-term Survival in Elderly Patients After Cancer Surgery: a Randomized Controlled Trial[NCT02660411] | 1,228 participants (Actual) | Interventional | 2015-04-01 | Completed | |||
| Impact of Inhalational Versus Intravenous Anesthesia Maintenance Methods on Incidence of Postoperative Delirium in Elderly Patients After Cancer Surgery: An Open-label, Randomized Controlled Trial[NCT02662257] | 1,228 participants (Actual) | Interventional | 2015-04-01 | Completed | |||
| Comparison of The Effectiveness of Intranasal Dexmedetomidine Sedation at Dose of 2 mcg/kg and 4 mcg/kg in Children Undergoing MRI at Cipto Mangunkusumo Hospital[NCT05091151] | 94 participants (Actual) | Interventional | 2019-02-01 | Completed | |||
| Dexmedetomidine Cycling and Sleep in the Pediatric ICU[NCT05003102] | Phase 4 | 0 participants (Actual) | Interventional | 2023-02-20 | Withdrawn (stopped due to No enrollment, IRB closed) | ||
| The Effect of a Dexmedetomidine-focussed Sleep Protocol* on Delirium Incidence and Healthcare Costs in Critically Ill Patients: A Prospective Randomized, Double-blind, Pilot Study.[NCT01791296] | Phase 4 | 100 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Impacts of Dexmedetomidine as an Adjuvant for Femoral Nerve Block on Functional Recovery in Aged Patients After Total Knee Arthroplasty: a Randomized, Double-blinded, Controlled Trial[NCT04642651] | Phase 4 | 170 participants (Actual) | Interventional | 2020-11-25 | Completed | ||
| Effect of Low-dose Dexmedetomidine on Postoperative Delirium in Patients After Cardiac Surgery: A Multicenter, Double-blinded, Randomized Controlled Trial[NCT03624595] | 502 participants (Anticipated) | Interventional | 2019-04-16 | Active, not recruiting | |||
| Non-interventional Comparison of Sedatives on Weaning From Mechanical Ventilation in Intensive Care Patients[NCT01707680] | 155 participants (Actual) | Observational | 2012-06-01 | Terminated (stopped due to Halted due to slow recruitment) | |||
| Effects of Dexmedetomidine at Different Doses on Hemodynamics and Recovery Quality in Elderly Patients Undergoing Hip Replacement Surgery Under General Anesthesia[NCT05567523] | Phase 4 | 200 participants (Actual) | Interventional | 2019-06-01 | Completed | ||
| Dexmedetomidine and IV Acetaminophen for the Prevention of Postoperative Delirium Following Cardiac Surgery in Adult Patients 60 Years of Age and Older[NCT02546765] | Phase 4 | 140 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| A Strategy to Reduce the Incidence of Post-Operative Delirium in Elderly Patients[NCT00590707] | 200 participants (Actual) | Interventional | 2005-01-31 | Completed | |||
| PANDORA: Scheduled Prophylactic 6-hourly Intravenous Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients[NCT04093219] | Phase 3 | 900 participants (Anticipated) | Interventional | 2020-08-11 | Recruiting | ||
| The EPigenetic Consequences in Children of Intravenous vs Volatile Anaesthesia for Surgery (EPIVA) - A Randomised, Feasibility Trial[NCT05936853] | 16 participants (Anticipated) | Interventional | 2023-07-31 | Not yet recruiting | |||
| Emergence Delirium and Recovery Time in Children: a Randomized Trial to Compare Total Intravenous Anesthesia With Propofol to Inhalational Sevoflurane Anesthesia for Ambulatory Dental Surgery[NCT03330613] | 120 participants (Anticipated) | Interventional | 2017-11-15 | Recruiting | |||
| Investigation of the DNA Methylation Profile in Children Who Presented Emergence Delirium[NCT03787849] | 175 participants (Actual) | Interventional | 2018-09-24 | Completed | |||
| EEG to Monitor Propofol Anesthetic Depth in Infants and Toddlers[NCT05701748] | 120 participants (Anticipated) | Interventional | 2023-02-03 | Recruiting | |||
| Effect of Flumazenil on Hypoactive Delirium in the ICU: A Double-Blind, Placebo-Controlled Pilot Study[NCT02899156] | Phase 4 | 22 participants (Actual) | Interventional | 2016-03-31 | Terminated (stopped due to A planned interim analysis led to the trial being stopped early based on the observed size effect and power analysis.) | ||
| An Assessment of Delirium in Mechanically Ventilated Patients Undergoing Daily Awakening From Sedation[NCT00919698] | 102 participants (Actual) | Observational | 2010-06-30 | Completed | |||
| Effectivity of 0.5 mg/kg Propofol in the End of Anesthesia to Reduce the Incidence of Postanesthetic Emergence Agitation in Pediatric Patients Under General Inhalation Anesthesia[NCT03528954] | 54 participants (Actual) | Interventional | 2018-05-31 | Completed | |||
| Cardioprotective Effect of Dexmedetomidine in Patients With ST-segment Elevation Myocardial Infarction: a Double-Blind, Multicenter, Randomized, Placebo-Controlled Clinical Trial[NCT04912518] | 250 participants (Anticipated) | Interventional | 2021-05-27 | Recruiting | |||
| Effect of Mini-dose Dexmedetomidine-Esketamine Infusion on Sleep Quality in Older Patients Undergoing Knee or Hip Replacement Surgery: A Multicenter Randomized Controlled Trial[NCT05950646] | Phase 4 | 154 participants (Anticipated) | Interventional | 2023-11-01 | Recruiting | ||
| Combined Use of Dexmedetomidine and Hydrocortisone to Prevent New Onset Atrial Fibrillation After Coronary Artery Bypass Grafting Surgery[NCT05674253] | Early Phase 1 | 248 participants (Anticipated) | Interventional | 2022-12-25 | Recruiting | ||
| The Effects of Operating Room Virtual Tour on Preoperative Anxiety, Emergence Delirium and Postoperative Behavioral Changes of Pediatric Patients: Prospective, Randomized, and Controlled Trial[NCT03172182] | 86 participants (Actual) | Interventional | 2017-08-01 | Completed | |||
| Low-dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Patients in Intensive Care Unit: a Multicenter, Randomised, Double-blinded, Placebo-controlled Trial[NCT03172897] | Phase 4 | 260 participants (Anticipated) | Interventional | 2017-08-20 | Suspended (stopped due to The trial was stopped because of difficulty in recruiting patients (another trial had similar inclusion/exclusion criteria). No patients was recruited in this trial.) | ||
| Low-Dose Dexmedetomidine for Delirium Prevention in Mechanically Ventilated Septic Patients in Intensive Care Unit: a Multi-Center, Randomized, Double-Blind, Placebo-Controlled Trial[NCT04876937] | 116 participants (Anticipated) | Interventional | 2021-05-28 | Recruiting | |||
| Postoperative Delirium After Total Knee Arthroplasty Under Regional Anesthesia: a Comparison Between Intraoperative Sedation With Fentanyl, Fentanyl-dexmedetomidine and Fentanyl-propofol[NCT03120442] | 600 participants (Anticipated) | Interventional | 2017-06-14 | Enrolling by invitation | |||
| Dexmedetomidine vs Propofol Sedation Reduces Postoperative Delirium in Patients Receiving Hip Arthroplasty.[NCT02793986] | 296 participants (Actual) | Interventional | 2015-08-31 | Completed | |||
| A Randomized Controlled Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia[NCT02190903] | 15 participants (Actual) | Interventional | 2013-10-31 | Completed | |||
| Effect of Regional Anaesthesia and General Anaesthesia on Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Surgery: a Multicenter Randomized Controlled Trial.[NCT02213380] | 950 participants (Actual) | Interventional | 2014-09-30 | Completed | |||
| The Influence of Postoperative Analgesia on Systemic Inflammatory Response and Postoperative Cognitive Disfunction in Elderly Patients After Surgical Repair of Femoral Fractures[NCT02848599] | Phase 2 | 86 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| Cukurova University Faculty of Medicine[NCT02360982] | 120 participants (Actual) | Observational | 2012-03-31 | Completed | |||
| [NCT01506622] | 222 participants (Actual) | Interventional | 2011-01-31 | Completed | |||
| A Prospective, Double-blind, Randomized Study to Investigate the Effect of Sugammadex vs. Neostigmine/Glycopyrrolate on Emergence Delirium During Sevoflurane-rocuronium Anesthesia in Pediatric Patients[NCT03229486] | Phase 4 | 40 participants (Actual) | Interventional | 2017-03-01 | Completed | ||
| Bispectral Index Monitoring In Pediatric Cataract Surgery: A Comparative Study Using Propofol- Midazolam Versus Sevoflurane Anesthesia[NCT05262205] | 100 participants (Anticipated) | Interventional | 2021-11-15 | Enrolling by invitation | |||
| Total Intravenous Anesthesia With Remifentanil-propofol Admixture Using Single-infusion Technique[NCT04394897] | 96 participants (Actual) | Observational | 2013-03-12 | Completed | |||
| Post Operative Cognitive Recovery and Neuropsychological Complications After General Anesthesia. A Comparison Between Different Techniques of Anesthesia: A Multi-Center Observational Study[NCT00507195] | 1,200 participants (Anticipated) | Observational | 2007-05-31 | Recruiting | |||
| Southern Medical University Clinical Research Project Initiative：Efficacy and Safety of a Multicomponent Physical Therapy Program in Mechanically Ventilated Patient With Sepsis[NCT03406494] | 800 participants (Anticipated) | Interventional | 2018-03-31 | Not yet recruiting | |||
| Namenda as Prevention for Post-Operative Delirium[NCT00303433] | Phase 4 | 30 participants | Interventional | 2006-03-31 | Terminated | ||
| Comparison of Large Antecubital Vein Versus Small Vein on Dorsum of Hand for the Prevention of Propofol Injection Pain[NCT04673500] | 160 participants (Actual) | Interventional | 2013-05-31 | Completed | |||
| A Multi-center, Double-blind, Randomized, Controlled Study to Determine the Efficacy and Safety of a New Formulation of Acetylcysteine Injection[NCT01118663] | Phase 3 | 17 participants (Actual) | Interventional | 2010-09-30 | Terminated | ||
| Comparison Between Ondansetron 8 mg and Lidocain 40 mg in Preventing Pain Due to Propofol Injection[NCT03134612] | Phase 2 | 104 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| Opioid Withdrawal Symptoms in Critically Ill Patients[NCT03374722] | 55 participants (Actual) | Observational | 2018-01-01 | Completed | |||
| Anesthesiological Strategies in Elective Craniotomy: Randomized, Equivalence, Open Trial[NCT00741351] | Phase 3 | 411 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| Effect of Dexmedetomidine of Gastrointestinal Motility[NCT04798482] | Phase 4 | 22 participants (Actual) | Interventional | 2021-09-14 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Duration of delirium will be analyzed, measured from 24 hours post-operation and daily until discharge. Additional measurements will be made at 1 month and 1 year after discharge. Delirium will be defined as an acute change in pre-operative baseline condition with additional features of inattention and either disorganized thinking and altered loss of consciousness, as defined by the Confusion Assessment Method (CAM). (NCT02546765)
Timeframe: Participants will be followed for the duration of the hospital stay, an average of 6 days, and at 1 month and 1- year following the date of surgery
| Intervention | days (Median) |
|---|---|
| Acetaminophen and Dexmedetomidine | 1 |
| Acetaminophen and Propofol | 1 |
| Placebo and Dexmedetomidine | 1 |
| Placebo and Propofol | 3 |
The follow up incidence of cognitive dysfunction will be analyzed at 1 month after discharge. T-MoCA is Telephone Montreal Cognitive Assessment Scale (MOCA). The T-MoCA is scored out of 22. The minimum score is 0 (worst) and maximum score is 22 (best). T-MOCA is converted back to 30 (full MOCA) with the help of conversion algorithms to a full MOCA.Example: 19/22 converts back to 30 by performing the following equation: (19×30) ÷ 22. The total converted score is 25.9 or 26/30 which is considered in the normal range. (NCT02546765)
Timeframe: Patients will be assessed for cognitive dysfunction with T-MOCA at 1 month following the date of surgery
| Intervention | units on a scale (Median) |
|---|---|
| Acetaminophen and Dexmedetomidine | 17 |
| Acetaminophen and Propofol | 18 |
| Placebo and Dexmedetomidine | 19 |
| Placebo and Propofol | 18 |
Defined by the number of days admitted in the hospital following the completion of surgery. (NCT02546765)
Timeframe: Measured in days admitted in the hospital, an average of 6 days
| Intervention | days (Median) |
|---|---|
| Acetaminophen and Dexmedetomidine | 8 |
| Acetaminophen and Propofol | 8 |
| Placebo and Dexmedetomidine | 9 |
| Placebo and Propofol | 8 |
Defined by the number of days admitted in the ICU prior to transfer to the general cardiac surgical floor (NCT02546765)
Timeframe: Measured in days admitted in the ICU, an average of 2 days
| Intervention | hours (Median) |
|---|---|
| Acetaminophen and Dexmedetomidine | 28.8 |
| Acetaminophen and Propofol | 30.3 |
| Placebo and Dexmedetomidine | 49.1 |
| Placebo and Propofol | 29.3 |
Incidence of delirium will be analyzed between patients treated with and without IV acetaminophen, measured from 24 hours post-operation and daily until discharge. Delirium will be defined as an acute change in pre-operative baseline condition with additional features of inattention and either disorganized thinking and altered loss of consciousness, as defined by the Confusion Assessment Method (CAM). (NCT02546765)
Timeframe: Participants will be followed for the duration of the hospital stay, an average of 5 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Acetaminophen and Dexmedetomidine | 2 |
| Acetaminophen and Propofol | 4 |
| Placebo and Dexmedetomidine | 8 |
| Placebo and Propofol | 9 |
MoCA scores at discharge will be reported in order to assess the occurrence of postoperative cognitive decline. Blinded study staff trained in administering the assessments will collect the data. MoCA is scored on a scale from 0 [worst] to 30 [best]; ǂA MoCA score of 24 would be equivalent to an Mini-Mental State Examination (MMSE) of about 27 or 28. Depending on education and peak intellectual attainment, such a score could be consistent with being either cognitively normal, or having very early mild cognitive impairment. Certainly such a person would be capable of living independently in the community and managing most or all of their affairs. (NCT02546765)
Timeframe: On the day of discharge, an average of 6 days
| Intervention | score on a scale (Median) |
|---|---|
| Acetaminophen and Dexmedetomidine | 23 |
| Acetaminophen and Propofol | 24 |
| Placebo and Dexmedetomidine | 24 |
| Placebo and Propofol | 23 |
Defined by the amount of additional opioid (IV morphine or hydromorphone) and oral acetaminophen medications required in the first 48 hours postoperatively. Values will be converted to morphine equivalents for analysis. Total morphine equivalent is calculated as the sum of (fentanyl dose x 100)+(hydromorphone dose x 4)+morphine dose+(oxycodone dose x 1.5) (NCT02546765)
Timeframe: Participants will be followed for the first 48 hours postoperatively.
| Intervention | mcg (Median) |
|---|---|
| Acetaminophen and Dexmedetomidine | 10050 |
| Acetaminophen and Propofol | 12611 |
| Placebo and Dexmedetomidine | 11382 |
| Placebo and Propofol | 12616 |
Severity of delirium will be analyzed, measured from 24 hours post-operation and daily until discharge. The worst severity experienced while in the hospital will be analyzed. Delirium will be defined as an acute change in pre-operative baseline condition with additional features of inattention and either disorganized thinking and altered loss of consciousness, as defined by the Confusion Assessment Method Severity Score (CAM-S, Confusion Assessment Method-Severity). range 0 [best/no delirium] to 19 [worst]; Minimal Clinical Important Difference (MCID) 2 points (NCT02546765)
Timeframe: Participants will be followed for the duration of the hospital stay, an average of 6 days
| Intervention | units on a scale (Median) |
|---|---|
| Acetaminophen and Dexmedetomidine | 10 |
| Acetaminophen and Propofol | 8 |
| Placebo and Dexmedetomidine | 6 |
| Placebo and Propofol | 9 |
Ability to perform Activities of Daily Living (ADL) using 6-point Katz activities of daily living scale, assessed at 12 months post-op. The range of the Katz activities of daily living scale is from 0-6, 0 is worse and 6 is best. (NCT00590707)
Timeframe: 12 months post-operative
| Intervention | units on a scale (Mean) |
|---|---|
| Deeper Sedation | 4.2 |
| Moderate Sedation | 4.1 |
"Clinical Dementia Rating consists of 6 domains (boxes) of function: memory, orientation, judgment and problem solving, community affairs, home and hobbies, and personal care. Each domain (box) is rated on a 5-point scale (0= no impairment, 0.5=questionable impairment, 1= mild impairment, 2= moderated impairment, 3= severe impairment. The CDR-SOB score is a sum of these ratings, for a total Sum of boxes ranging from 0-18, where 0=cognitively intact. Increasing sum of boxes score is associated with greater cognitive impairment." (NCT00590707)
Timeframe: 12 months post-operative
| Intervention | units on a scale (Mean) |
|---|---|
| Deeper Sedation | 2.0 |
| Moderate Sedation | 2.0 |
death occurring during follow-up period, in one year post-op. (NCT00590707)
Timeframe: 12 months post-operative
| Intervention | Participants (Count of Participants) |
|---|---|
| Deeper Sedation | 14 |
| Moderate Sedation | 14 |
The presence of delirium is assessed by the confusion assessment method (CAM), during postoperative Day 1 to Day 5 or up to hospital discharge, whichever occurs first. The CAM consists of 4 features: 1-Onset, 2-Inattention, 3-Disorganized thinking, and 4-altered level of consciousness. The diagnosis of delirium by CAM is based on the presence of features 1 and 2, and either 3 or 4. (NCT00590707)
Timeframe: Postoperative days up to hospital discharge
| Intervention | Participants (Count of Participants) |
|---|---|
| Deeper Sedation | 39 |
| Moderate Sedation | 34 |
The presence of delirium is assessed by the confusion assessment method (CAM), after 1 month postoperative. The CAM consists of 4 features: 1-Onset, 2-Inattention, 3-Disorganized thinking, and 4-altered level of consciousness. The diagnosis of delirium by CAM is based on the presence of features 1 and 2, and either 3 or 4. (NCT00590707)
Timeframe: 1 month (30 days) post-intervention
| Intervention | Participants (Count of Participants) |
|---|---|
| Deeper Sedation | 3 |
| Moderate Sedation | 1 |
average duration of time patient was randomized to each infusion up to 72 hours (NCT02899156)
Timeframe: up to 72 hours after the start of the infusion
| Intervention | hours (Mean) |
|---|---|
| Flumazenil Group | 54.8 |
| Placebo Group | 58.2 |
average maximum rate (ml/hr) during the 72 hours after study infusion (NCT02899156)
Timeframe: up to 72 hours after the start of the infusion
| Intervention | milliliters per hour (Mean) |
|---|---|
| Flumazenil Group | 5 |
| Placebo Group | 5.2 |
length of time that the patient was admitted to an intensive care unit service during the hospital stay (NCT02899156)
Timeframe: duration of admission to the intensive care unit
| Intervention | days (Mean) |
|---|---|
| Flumazenil Group | 7.8 |
| Placebo Group | 7 |
Defined by the number of days in the 14-day period after randomization that the patient was alive and not delirious (i.e. CAM-ICU negative). Zero delirium-free days will be observed for patients that die within the 14-day period. (NCT02899156)
Timeframe: up to 14 days after randomization
| Intervention | days (Median) |
|---|---|
| Flumazenil Group | 12.7 |
| Placebo Group | 9.2 |
number of days within the first 28 days after enrollment that the patient was free from needing mechanical ventilation (NCT02899156)
Timeframe: up to 28 days after randomization
| Intervention | days (Mean) |
|---|---|
| Flumazenil Group | 23.6 |
| Placebo Group | 24.9 |
defined by the proportion of patients who were delirium free at 14 days after randomization (NCT02899156)
Timeframe: up to 14 days after randomization
| Intervention | Participants (Count of Participants) |
|---|---|
| Flumazenil Group | 9 |
| Placebo Group | 7 |
number of times that a RASS score of + 2 to +4 occurred that did not resolve with decreasing study infusion (NCT02899156)
Timeframe: up to 72 hours after the start of the infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Flumazenil Group | 0 |
| Placebo Group | 0 |
Delirium will be assessed by the Confusion Assessment Method Instrument (CAM), a validated method of assessing delirium based on the presence of both (1) an acute onset of signs and symptoms with a fluctuating course AND (2) inattention; PLUS (3) disorganized thinking OR (4) an altered level of consciousness. (NCT02190903)
Timeframe: Up to 5 days post hip fracture surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| General Endotracheal Anesthesia | 2 |
| Regional (Spinal) Anesthesia | 0 |
Mortality within 30 days post operation (NCT02213380)
Timeframe: 30 days after surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| Group RA | 8 |
| Group GA | 4 |
The worst pain score within 7 days post-operation in both groups. The visual analog scale (VAS) is a validated, subjective measure for acute and chronic pain. Scores are recorded by making a handwritten mark on a 10-cm line that represents a continuum between no pain(0 point) to worst pain (100 points). (NCT02213380)
Timeframe: In 7days post operation
| Intervention | score on a scale (Median) |
|---|---|
| Group RA | 0 |
| Group GA | 0 |
Costs of anesthetic procedure only (NCT02213380)
Timeframe: 1 day after operation
| Intervention | dollars (Median) |
|---|---|
| Group RA | 159 |
| Group GA | 268 |
Length of hospital stay are measured from the anesthesia starting day to the discharge day (NCT02213380)
Timeframe: till the day of discharge from hospital, an average of 7 days
| Intervention | days (Median) |
|---|---|
| Group RA | 7 |
| Group GA | 7 |
Post-operative delirium diagnosed with Confusion Assessment Method (NCT02213380)
Timeframe: in 7 days post operation
| Intervention | Participants (Count of Participants) |
|---|---|
| Group RA | 29 |
| Group GA | 24 |
The worst severity scores of delirium was diagnosed with the DRS-R-98 within 7 days (NCT02213380)
Timeframe: within first 7days post operation
| Intervention | score on a scale (Mean) |
|---|---|
| Group RA | 23.48 |
| Group GA | 24.22 |
Entire expenditure in-hospital (NCT02213380)
Timeframe: till the day of discharge
| Intervention | dollars (Median) |
|---|---|
| Group RA | 5582 |
| Group GA | 5908 |
Duration of postoperative hospital stay in days (NCT02848599)
Timeframe: 14 days
| Intervention | days (Median) |
|---|---|
| Morphine | 7 |
| Levobupivacaine | 7 |
Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery
| Intervention | mg/L (Median) | |||
|---|---|---|---|---|
| Before surgery | 24 h after surgery | 72 h after surgery | 120 h after surgery | |
| Levobupivacaine | 57.8 | 98.1 | 95 | 54.6 |
| Morphine | 57.2 | 106.2 | 118.5 | 66.9 |
"Assessment of cognitive function will be done using the Mini-mental state examination (MMSE) rating scales before and 24,48,72,96 and 120 hours after the surgery at the same time every morning.~Mini-Mental State Examination Scale: minimum score is 0 and maximum score is 30; the severity of cognitive impairment: no cognitive impairment=25-30; mild cognitive impairment=19-24; moderate cognitive impairment=10-18; and severe cognitive impairment<9. Higher scores mean a better and lower scores mean a worse outcome." (NCT02848599)
Timeframe: Before, 24,48,72,96 and 120 hours after the surgery
| Intervention | score on a scale (Median) | |||||
|---|---|---|---|---|---|---|
| Before surgery | 24 h after surgery | 48 h after surgery | 72 h after surgery | 96 h after surgery | 120 h after surgery | |
| Levobupivacaine | 22 | 22 | 21 | 21 | 21 | 22 |
| Morphine | 21 | 20 | 20 | 20 | 20 | 20 |
Measurement will be done before and 24,72 and 120 hours after the surgery. (NCT02848599)
Timeframe: Before, 24,72 and 120 hours after the surgery
| Intervention | g/L (Median) | |||
|---|---|---|---|---|
| Before surgery | 24 h after surgery | 72 h after surgery | 120 h after surgery | |
| Levobupivacaine | 4.5 | 4.7 | 5.2 | 5 |
| Morphine | 5.5 | 5.3 | 5.7 | 5.4 |
"Assessment will be done using Numeric Rating Scale (NRS). During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily. Median of 8 time points measurements during the first 24, 48 and 72 hours after the surgery will be reported. After that, median of 3 time points will be reported from the 4. to 6. postoperative day and on the day of discharge.~Minimum score 0 and maximum score 10 ( 0-No Pain; 1-3 Mild Pain; 4-6 Moderate Pain; 7-10 Severe Pain ). Higher scores mean a worse and lower scores mean a better outcome." (NCT02848599)
Timeframe: During the first 72 hours after the surgery assessment will be done every 3 hours, after that assessment will be done 3 times daily until discharge
| Intervention | score on a scale (Median) | ||||||
|---|---|---|---|---|---|---|---|
| 3,6,9,12,15,18,21 and 24h after surgery | 27,30,33,36,39,42,45 and 48h after surgery | 51,54,57,60,63,66,69 and 72h after surgery | 4. postoperative day (every 8 hours) | 5. postoperative day (every 8 hours) | 6. postoperative day (every 8 hours) | Day of discharge | |
| Levobupivacaine | 0.6 | 0.5 | 0.5 | 0.3 | 0 | 0 | 0 |
| Morphine | 1.4 | 1.5 | 1.4 | 1.4 | 1.4 | 1.3 | 1 |
Measurement will be done before and 24 and 72 hours after the surgery. (NCT02848599)
Timeframe: Before, 24 and 72 hours after the surgery
| Intervention | pg/ml (Median) | ||
|---|---|---|---|
| Before surgery | 24h after surgery | 72h after surgery | |
| Levobupivacaine | 26.6 | 97.7 | 30.5 |
| Morphine | 27.2 | 104 | 50 |
Maximum Pediatric Anesthesia Emergence Delirium (PAED) score after arrival in the PACU.Higher values represent more emergence delirium (worse) PAED Score is represented with total PAED score summed up of subscales. The total score is reported and it ranges from 0 to 20. Higher score means worse state. (NCT03229486)
Timeframe: within 30 minutes after arrival at post-anesthesia care unit (PACU)
| Intervention | units on a scale (Median) |
|---|---|
| Sugammadex | 18 |
| Neostigmine | 18 |
Time from the start of administration of reversal agents to recovery of the TOF ratio to 0.7 (NCT03229486)
Timeframe: Time from the start of administration of reversal agents to recovery of the TOF ratio to 0.7, assessed up to 60 minutes
| Intervention | seconds (Mean) |
|---|---|
| Sugammadex | 72.7 |
| Neostigmine | 167.4 |
Time from the start of administration of reversal agents to recovery of the TOF ratio to 0.8 (NCT03229486)
Timeframe: Time from the start of administration of reversal agents to recovery of the TOF ratio to 0.8, assessed up to 60 minutes
| Intervention | seconds (Mean) |
|---|---|
| Sugammadex | 83.9 |
| Neostigmine | 213.6 |
Time from the start of administration of reversal agents to recovery of the TOF ratio to 0.9 (NCT03229486)
Timeframe: Time from the start of administration of reversal agents to recovery of the TOF ratio to 0.9, assessed up to 60 minutes
| Intervention | seconds (Mean) |
|---|---|
| Sugammadex | 99.6 |
| Neostigmine | 253.1 |
time from administration of reversal agent to time of eye opening or child showing purposeful movement (NCT03229486)
Timeframe: time from administration of reversal agent to time of eye opening or child showing purposeful movements, assessed up to 60 minutes
| Intervention | seconds (Mean) |
|---|---|
| Sugammadex | 275.8 |
| Neostigmine | 371.2 |
time from administration of reversal agent to time of tracheal extubation (NCT03229486)
Timeframe: time from administration of reversal agent to time of tracheal extubation, assessed up to 60 minutes
| Intervention | seconds (Mean) |
|---|---|
| Sugammadex | 312.1 |
| Neostigmine | 427.3 |
time from administration of reversal agent to time of deep, regular breathing (NCT03229486)
Timeframe: time from administration of reversal agent to time of deep, regular breathing, assessed up to 60 minutes
| Intervention | seconds (Mean) |
|---|---|
| Sugammadex | 273.8 |
| Neostigmine | 345.1 |
Data analysis was conducted on the subjects enrolled in the study prior to study termination. Because the study was terminated prematurely due to lack of enrollment, there was an insufficient sample size to conduct an efficacy analysis. (NCT01118663)
Timeframe: 1 hour
| Intervention | participants (Number) |
|---|---|
| Acetadote Without EDTA | 0 |
| Acetadote | 1 |
(NCT01118663)
Timeframe: 21-42 hours
| Intervention | Number of Events (Number) |
|---|---|
| Acetadote Without EDTA | 13 |
| Acetadote | 14 |
12 reviews available for propofol and Delirium of Mixed Origin
| Article | Year |
|---|---|
Outcomes of dexmedetomidine versus propofol sedation in critically ill adults requiring mechanical ventilation: a systematic review and meta-analysis of randomised controlled trials.
Topics: Adult; Bradycardia; Critical Illness; Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives; In | 2022 |
Prevention and treatment of traumatic brain injury-related delirium: a systematic review.
Topics: Adult; Aged; Brain Injuries, Traumatic; Delirium; Haloperidol; Humans; Middle Aged; Propofol | 2023 |
Dexmedetomidine versus propofol sedation in reducing delirium among older adults in the ICU: A systematic review and meta-analysis.
Topics: Aged; Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Propofol; Re | 2020 |
Sedation for critically ill patients with COVID-19: Which specificities? One size does not fit all.
Topics: Analgesics, Opioid; Betacoronavirus; Coronavirus Infections; COVID-19; Critical Illness; Deep Sedati | 2020 |
Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery.
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave | 2018 |
Prevention of sevoflurane delirium and agitation with propofol.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Consciousness Monitors; Delirium; Humans; Methyl | 2013 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting.
Topics: Clonidine; Conscious Sedation; Critical Care; Delirium; Dexmedetomidine; Drug Interactions; Humans; | 2015 |
Dexmedetomidine vs propofol sedation reduces delirium in patients after cardiac surgery: A meta-analysis with trial sequential analysis of randomized controlled trials.
Topics: Coronary Artery Bypass; Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care U | 2017 |
Sedation and analgesia in acute neurologic disease.
Topics: Acute Disease; Analgesia; Antipsychotic Agents; Anxiety; Conscious Sedation; Critical Care; Delirium | 2010 |
Propofol.
Topics: Anesthetics, Intravenous; Death; Delirium; Drug Interactions; Humans; Propofol | 2010 |
Management of agitation in the intensive care unit.
Topics: Benzodiazepines; Clinical Protocols; Critical Care; Critical Illness; Delirium; Humans; Hypnotics an | 2003 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
56 trials available for propofol and Delirium of Mixed Origin
| Article | Year |
|---|---|
Thoracic Paravertebral Block Ameliorates Postoperative Delirium in Geriatric Patients.
Topics: Aged; Delirium; Humans; Nausea; Pain, Postoperative; Propofol; Pulmonary Atelectasis; Remifentanil; | 2022 |
Effect of remimazolam besylate compared with propofol on the incidence of delirium after cardiac surgery: study protocol for a randomized trial.
Topics: Benzodiazepines; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Humans; Hypnotics and Sedat | 2021 |
Effect of Electroencephalography Spectral Edge Frequency (SEF) and Patient State Index (PSI)-Guided Propofol-Remifentanil Anesthesia on Delirium After Laparoscopic Surgery: The eMODIPOD Randomized Controlled Trial.
Topics: Anesthesia; Anesthesia, General; Delirium; Electroencephalography; Humans; Laparoscopy; Middle Aged; | 2022 |
Dexmedetomidine Use in Intensive Care Unit Sedation and Postoperative Recovery in Elderly Patients Post-Cardiac Surgery (DIRECT).
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives; Inten | 2022 |
Effect of additional equipotent fentanyl or sufentanil administration on recovery profiles during propofol-remifentanil-based anaesthesia in patients undergoing gynaecologic laparoscopic surgery: a randomized clinical trial.
Topics: Anesthesia; Delirium; Dizziness; Female; Fentanyl; Humans; Laparoscopy; Nausea; Propofol; Remifentan | 2022 |
Comparing propofol anaesthesia guided by Bispectral Index monitoring and frontal EEG wave analysis with standard monitoring in laparoscopic surgery: protocol for the 'EEG in General Anaesthesia - More Than Only a Bispectral Index' Trial, a multicentre, do
Topics: Anesthesia, General; Delirium; Electroencephalography; Humans; Laparoscopy; Multicenter Studies as T | 2022 |
The Preventive Effect of Transcutaneous Electrical Acupoint Stimulation on Postoperative Delirium in Elderly Patients with Time Factors: A Randomized Trial.
Topics: Acupuncture Points; Aged; Delirium; Humans; Propofol; Time Factors; Transcutaneous Electric Nerve St | 2022 |
Impact of propofol versus sevoflurane on the incidence of postoperative delirium in elderly patients after spine surgery: study protocol of a randomized controlled trial.
Topics: Aged; Anesthetics, Inhalation; Delirium; Humans; Incidence; Propofol; Randomized Controlled Trials a | 2022 |
Cognitive function and delirium following sevoflurane or propofol anesthesia for valve replacement surgery: A multicenter randomized controlled trial.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Cognition; Delirium; Humans; | 2023 |
Postoperative Delirium after Dexmedetomidine versus Propofol Sedation in Healthy Older Adults Undergoing Orthopedic Lower Limb Surgery with Spinal Anesthesia: A Randomized Controlled Trial.
Topics: Aged; Anesthesia, Spinal; Delirium; Dexmedetomidine; Emergence Delirium; Humans; Hypnotics and Sedat | 2023 |
Effect of Remimazolam on Postoperative Delirium in Older Adult Patients Undergoing Orthopedic Surgery: A Prospective Randomized Controlled Clinical Trial.
Topics: Aged; Benzodiazepines; Delirium; Emergence Delirium; Humans; Orthopedic Procedures; Propofol | 2023 |
Comparison of the effects of remimazolam tosylate and propofol on postoperative delirium among older adults undergoing major non-cardiac surgery: protocol for a randomised controlled trial.
Topics: Aged; Delirium; Emergence Delirium; Humans; Postoperative Complications; Propofol; Randomized Contro | 2023 |
Effects of Different Injection Rates of Propofol on Postoperative Cognition in Elderly Patients Undergoing Laparoscopic Inguinal Hernia Repair.
Topics: Aged; Anesthetics, Intravenous; Cognition; Delirium; Hernia, Inguinal; Humans; Laparoscopy; Postoper | 2023 |
Delirium in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: a multicentre randomised trial. Comment on Br J Anaesth 2023; 131: 253-65.
Topics: Aged; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Delirium; Humans; Methyl Ethers | 2023 |
Dexmedetomidine vs. propofol sedation reduces the duration of mechanical ventilation after cardiac surgery - a randomized controlled trial.
Topics: Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Humans; Propofol; Respiration, Artificial | 2023 |
Delirium in older patients given propofol or sevoflurane anaesthesia for major cancer surgery: a multicentre randomised trial. Comment on Br J Anaesth 2023; 131: 253-65.
Topics: Aged; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Delirium; Humans; Methyl Ethers | 2023 |
Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients.
Topics: Aged; Aged, 80 and over; Coma; Conscious Sedation; Critical Illness; Delirium; Female; Humans; Hypno | 2020 |
The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study.
Topics: Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intra | 2020 |
Propofol plus low-dose dexmedetomidine infusion and postoperative delirium in older patients undergoing cardiac surgery.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Dose-Response Relationship, Drug; Doub | 2021 |
The effect of desflurane versus propofol anesthesia on postoperative delirium in elderly obese patients undergoing total knee replacement: A randomized, controlled, double-blinded clinical trial.
Topics: Aged; Anesthesia, General; Arthroplasty, Replacement, Knee; Cognitive Dysfunction; Delirium; Desflur | 2017 |
Postoperative Delirium in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting According to the Anesthetic Agent: A Retrospective Study.
Topics: Aged; Aged, 80 and over; Anesthetics; Coronary Artery Bypass, Off-Pump; Delirium; Female; Humans; Ma | 2017 |
Comparison of propofol and dexmedetomidine infused overnight to treat hyperactive and mixed ICU delirium: a protocol for the Basel ProDex clinical trial.
Topics: Critical Illness; Delirium; Dexmedetomidine; Electroencephalography; Humans; Hypnotics and Sedatives | 2017 |
Impact of inhalational versus intravenous anaesthesia on early delirium and long-term survival in elderly patients after cancer surgery: study protocol of a multicentre, open-label, and randomised controlled trial.
Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Chi | 2017 |
Impact of inhalational versus intravenous anaesthesia on early delirium and long-term survival in elderly patients after cancer surgery: study protocol of a multicentre, open-label, and randomised controlled trial.
Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Chi | 2017 |
Impact of inhalational versus intravenous anaesthesia on early delirium and long-term survival in elderly patients after cancer surgery: study protocol of a multicentre, open-label, and randomised controlled trial.
Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Chi | 2017 |
Impact of inhalational versus intravenous anaesthesia on early delirium and long-term survival in elderly patients after cancer surgery: study protocol of a multicentre, open-label, and randomised controlled trial.
Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Chi | 2017 |
Sedation for magnetic resonance imaging using propofol with or without ketamine at induction in pediatrics-A prospective randomized double-blinded study.
Topics: Anesthesia Recovery Period; Anesthetics, Dissociative; Child; Child, Preschool; Conscious Sedation; | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Low-Dose Nocturnal Dexmedetomidine Prevents ICU Delirium. A Randomized, Placebo-controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Aged, 80 and over; Benzodiazepines; Critical Care; Critica | 2018 |
Intraoperative Sedation With Dexmedetomidine is Superior to Propofol for Elderly Patients Undergoing Hip Arthroplasty: A Prospective Randomized Controlled Study.
Topics: Aged; Arthroplasty, Replacement, Hip; Cognitive Dysfunction; Delirium; Dexmedetomidine; Female; Huma | 2018 |
Dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium following cardiac surgery (DEXACET trial): protocol for a prospective randomized controlled trial.
Topics: Acetaminophen; Administration, Intravenous; Analgesics, Non-Narcotic; Boston; Cardiac Surgical Proce | 2018 |
Effect of Depth of Sedation in Older Patients Undergoing Hip Fracture Repair on Postoperative Delirium: The STRIDE Randomized Clinical Trial.
Topics: Aged; Aged, 80 and over; Anesthesia Recovery Period; Anesthesia, Spinal; Anesthetics, Intravenous; C | 2018 |
Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial.
Topics: Acetaminophen; Administration, Intravenous; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analg | 2019 |
Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial.
Topics: Acetaminophen; Administration, Intravenous; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analg | 2019 |
Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial.
Topics: Acetaminophen; Administration, Intravenous; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analg | 2019 |
Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial.
Topics: Acetaminophen; Administration, Intravenous; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Analg | 2019 |
Effect of perioperative administration of dexmedetomidine on delirium after cardiac surgery in elderly patients: a double-blinded, multi-center, randomized study.
Topics: Aged; Analgesics; Analgesics, Opioid; Anesthesia, General; Cardiac Surgical Procedures; Delirium; De | 2019 |
Emergence delirium in children: a randomized trial to compare total intravenous anesthesia with propofol and remifentanil to inhalational sevoflurane anesthesia.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation | 2013 |
Emergence delirium in children: a randomized trial to compare total intravenous anesthesia with propofol and remifentanil to inhalational sevoflurane anesthesia.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation | 2013 |
Emergence delirium in children: a randomized trial to compare total intravenous anesthesia with propofol and remifentanil to inhalational sevoflurane anesthesia.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation | 2013 |
Emergence delirium in children: a randomized trial to compare total intravenous anesthesia with propofol and remifentanil to inhalational sevoflurane anesthesia.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation | 2013 |
Emergence delirium in children: a randomized trial to compare total intravenous anesthesia with propofol and remifentanil to inhalational sevoflurane anesthesia.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation | 2013 |
Emergence delirium in children: a randomized trial to compare total intravenous anesthesia with propofol and remifentanil to inhalational sevoflurane anesthesia.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation | 2013 |
Emergence delirium in children: a randomized trial to compare total intravenous anesthesia with propofol and remifentanil to inhalational sevoflurane anesthesia.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation | 2013 |
Emergence delirium in children: a randomized trial to compare total intravenous anesthesia with propofol and remifentanil to inhalational sevoflurane anesthesia.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation | 2013 |
Emergence delirium in children: a randomized trial to compare total intravenous anesthesia with propofol and remifentanil to inhalational sevoflurane anesthesia.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation | 2013 |
Effect of the intraoperative wake-up test in sevoflurane-sufentanil combined anesthesia during adolescent idiopathic scoliosis surgery: a randomized study.
Topics: Adolescent; Airway Extubation; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Int | 2013 |
Propofol-remifentanil or sevoflurane for children undergoing magnetic resonance imaging? A randomised study.
Topics: Anesthesia Recovery Period; Anesthetics, Inhalation; Child; Child, Preschool; Delirium; Double-Blind | 2013 |
Early goal-directed sedation versus standard sedation in mechanically ventilated critically ill patients: a pilot study*.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Airway Extubation; Algorithms; APACHE; Benzodiazepines; | 2013 |
A comparison of single-dose dexmedetomidine or propofol on the incidence of emergence delirium in children undergoing general anaesthesia for magnetic resonance imaging.
Topics: Anesthesia Recovery Period; Anesthesia, General; Child; Child, Preschool; Delirium; Dexmedetomidine; | 2015 |
Transition to propofol after sevoflurane anesthesia to prevent emergence agitation: a randomized controlled trial.
Topics: Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; Causality; Child; Chi | 2015 |
[Sedative effects of dexmedetomidine in post-operative elder patients on mechanical ventilation].
Topics: Aged; Analgesics; Delirium; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Ca | 2014 |
A comparison of single dose dexmedetomidine with propofol for the prevention of emergence delirium after desflurane anaesthesia in children.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Delirium; Desflurane; Dexmedetomidine; Female; Hum | 2016 |
A comparison of single dose dexmedetomidine with propofol for the prevention of emergence delirium after desflurane anaesthesia in children.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Delirium; Desflurane; Dexmedetomidine; Female; Hum | 2016 |
A comparison of single dose dexmedetomidine with propofol for the prevention of emergence delirium after desflurane anaesthesia in children.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Delirium; Desflurane; Dexmedetomidine; Female; Hum | 2016 |
A comparison of single dose dexmedetomidine with propofol for the prevention of emergence delirium after desflurane anaesthesia in children.
Topics: Anesthetics, Inhalation; Child; Child, Preschool; Delirium; Desflurane; Dexmedetomidine; Female; Hum | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
Dexmedetomidine versus Propofol Sedation Reduces Delirium after Cardiac Surgery: A Randomized Controlled Trial.
Topics: Aged; Cardiac Surgical Procedures; Delirium; Dexmedetomidine; Female; Humans; Hypnotics and Sedative | 2016 |
[Study of prevention and control of delirium in ventilated patients by simulating blockage of circadian rhythm with sedative in intensive care unit].
Topics: Analgesics; Circadian Rhythm; Critical Care; Delirium; Dexmedetomidine; Fentanyl; Humans; Hypnotics | 2016 |
Total intravenous anesthesia with propofol is associated with a lower rate of postoperative delirium in comparison with sevoflurane anesthesia in elderly patients.
Topics: Aged; Aged, 80 and over; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Inhalatio | 2016 |
Emergence agitation in children after propofol versus halothane anesthesia.
Topics: Anesthesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; Child; De | 2009 |
Quality of recovery from two types of general anesthesia for ambulatory dental surgery in children: a double-blind, randomized trial.
Topics: Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Dental; Anesthesia, Inhalati | 2009 |
Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM Study).
Topics: Adrenergic alpha-Agonists; Aged; Analgesics, Opioid; Delirium; Dexmedetomidine; Double-Blind Method; | 2009 |
Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM Study).
Topics: Adrenergic alpha-Agonists; Aged; Analgesics, Opioid; Delirium; Dexmedetomidine; Double-Blind Method; | 2009 |
Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM Study).
Topics: Adrenergic alpha-Agonists; Aged; Analgesics, Opioid; Delirium; Dexmedetomidine; Double-Blind Method; | 2009 |
Prevalence of delirium with dexmedetomidine compared with morphine based therapy after cardiac surgery: a randomized controlled trial (DEXmedetomidine COmpared to Morphine-DEXCOM Study).
Topics: Adrenergic alpha-Agonists; Aged; Analgesics, Opioid; Delirium; Dexmedetomidine; Double-Blind Method; | 2009 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Sedation depth during spinal anesthesia and the development of postoperative delirium in elderly patients undergoing hip fracture repair.
Topics: Aged, 80 and over; Anesthesia, Spinal; Conscious Sedation; Deep Sedation; Delirium; Double-Blind Met | 2010 |
Emergence agitation after cataract surgery in children: a comparison of midazolam, propofol and ketamine.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Inhalation; | 2010 |
Emergence delirium and postoperative pain in children undergoing adenotonsillectomy: a comparison of propofol vs sevoflurane anesthesia.
Topics: Adenoidectomy; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthet | 2010 |
Emergence delirium and postoperative pain in children undergoing adenotonsillectomy: a comparison of propofol vs sevoflurane anesthesia.
Topics: Adenoidectomy; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthet | 2010 |
Emergence delirium and postoperative pain in children undergoing adenotonsillectomy: a comparison of propofol vs sevoflurane anesthesia.
Topics: Adenoidectomy; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthet | 2010 |
Emergence delirium and postoperative pain in children undergoing adenotonsillectomy: a comparison of propofol vs sevoflurane anesthesia.
Topics: Adenoidectomy; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthet | 2010 |
Early postoperative cognitive dysfunction and postoperative delirium after anaesthesia with various hypnotics: study protocol for a randomised controlled trial--the PINOCCHIO trial.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Cognition; Cognition Disorde | 2011 |
A reorientation strategy for reducing delirium in the critically ill. Results of an interventional study.
Topics: Acoustic Stimulation; Aged; Aged, 80 and over; Antipsychotic Agents; Benzodiazepines; Critical Care; | 2012 |
Recovery characteristics and post-operative delirium after long-duration laparoscope-assisted surgery in elderly patients: propofol-based vs. sevoflurane-based anesthesia.
Topics: Aged; Analgesia, Epidural; Cognition Disorders; Delirium; Female; Humans; Incidence; Laparoscopy; Ma | 2004 |
Recovery characteristics and post-operative delirium after long-duration laparoscope-assisted surgery in elderly patients: propofol-based vs. sevoflurane-based anesthesia.
Topics: Aged; Analgesia, Epidural; Cognition Disorders; Delirium; Female; Humans; Incidence; Laparoscopy; Ma | 2004 |
Recovery characteristics and post-operative delirium after long-duration laparoscope-assisted surgery in elderly patients: propofol-based vs. sevoflurane-based anesthesia.
Topics: Aged; Analgesia, Epidural; Cognition Disorders; Delirium; Female; Humans; Incidence; Laparoscopy; Ma | 2004 |
Recovery characteristics and post-operative delirium after long-duration laparoscope-assisted surgery in elderly patients: propofol-based vs. sevoflurane-based anesthesia.
Topics: Aged; Analgesia, Epidural; Cognition Disorders; Delirium; Female; Humans; Incidence; Laparoscopy; Ma | 2004 |
Withdrawal following sufentanil/propofol and sufentanil/midazolam. Sedation in surgical ICU patients: correlation with central nervous parameters and endogenous opioids.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; beta-Endorphin; Blood Pressure; Conscious Sedation; Cri | 2005 |
[Compared effects of etomidate and propofol for anaesthesia during electroconvulsive therapy].
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Bipolar Disorder; Blood Pressure; Chi-Squa | 2005 |
Remifentanil vs fentanyl with a target controlled propofol infusion in patients undergoing craniotomy for supratentorial lesions.
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; Cranioto | 2006 |
Midazolam does not reduce emergence delirium after sevoflurane anesthesia in children.
Topics: Administration, Rectal; Age Factors; Akathisia, Drug-Induced; Anesthesia, General; Anesthetics, Inha | 2007 |
Effect of propofol on emergence behavior in children after sevoflurane general anesthesia.
Topics: Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2008 |
Open-label, prospective, randomized comparison of propofol and sevoflurane for laryngeal mask anesthesia for magnetic resonance imaging in pediatric patients.
Topics: Anesthesia Recovery Period; Anesthetics, General; Child; Child, Preschool; Delirium; Female; Humans; | 2008 |
60 other studies available for propofol and Delirium of Mixed Origin
| Article | Year |
|---|---|
Differential Effects of Gamma-Aminobutyric Acidergic Sedatives on Risk of Post-Extubation Delirium in the ICU: A Retrospective Cohort Study From a New England Health Care Network.
Topics: Adult; Aged; Airway Extubation; Benzodiazepines; Delirium; Delivery of Health Care; Humans; Hypnotic | 2022 |
Comparison of total intravenous with inhalational anesthesia in terms of postoperative delirium and complications in older patients: a nationwide population-based study.
Topics: Aged; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Delirium; Humans; | 2022 |
Critical considerations, including overfitting in regression models and confounding in study designs for delirium follow-up.
Topics: Anesthesia, General; Benzodiazepines; Delirium; Follow-Up Studies; Humans; Incidence; Propofol; Retr | 2023 |
Predictors of Low Risk for Delirium during Anesthesia Emergence.
Topics: Anesthesia Recovery Period; Anesthesia, General; Delirium; Electroencephalography; Humans; Middle Ag | 2023 |
Propofol for palliative sedation.
Topics: Delirium; Female; Humans; Hypnotics and Sedatives; Middle Aged; Pain; Palliative Care; Propofol; Psy | 2020 |
Sedation selection to reduce delirium risk: Why dexmedetomidine may be a better choice.
Topics: Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives; Intensive Care Units; Propofol | 2020 |
Severe delirium after GHB abuse.
Topics: Baclofen; Delirium; Female; Humans; Propofol; Sodium Oxybate; Substance Withdrawal Syndrome | 2020 |
Prevalence of delirium in intensive care patients and association with sedoanalgesia, severity and mortality.
Topics: Analgesics; Chi-Square Distribution; Clonidine; Critical Care; Cross-Sectional Studies; Delirium; Fe | 2020 |
Effectiveness of Quetiapine as a Sedative Adjunct in Mechanically Ventilated Adults Without Delirium.
Topics: Adjuvants, Pharmaceutic; Adult; Analgesics, Opioid; Benzodiazepines; Cohort Studies; Delirium; Dexme | 2021 |
Inadvertent Burst Suppression During Total Intravenous Anesthesia in 112 Consecutive Patients Undergoing Spinal Instrumentation Surgery: A Retrospective Observational Quality Improvement Project.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Anesthesia, Intravenous; Delirium; Electroencep | 2022 |
Current Evidence Demonstrates a Significant Reduction in the Incidence of Delirium With Postoperative Dexmedetomidine Versus Propofol Sedation.
Topics: Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives; Incidence; Propofol | 2022 |
Dexmedetomidine versus Propofol Sedation for Prevention of Postoperative Delirium: Clarifications Required [Letter].
Topics: Delirium; Dexmedetomidine; Humans; Hypnotics and Sedatives; Propofol | 2021 |
Bispectral Index monitoring in cancer patients undergoing palliative sedation: a preliminary report.
Topics: Adult; Aged; Awareness; Cancer Pain; Conscious Sedation; Consciousness; Delirium; Electroencephalogr | 2017 |
Effect of Sedation Regimen on Weaning from Mechanical Ventilation in the Intensive Care Unit.
Topics: Adult; Aged; Aged, 80 and over; Anxiety; Critical Care; Delirium; Dexmedetomidine; Female; Humans; H | 2018 |
Comparison of Ketamine- Versus Nonketamine-Based Sedation on Delirium and Coma in the Intensive Care Unit.
Topics: Academic Medical Centers; Aged; Coma; Critical Care Outcomes; Delirium; Dexmedetomidine; Female; Hum | 2020 |
Depth of Propofol Sedation and Postoperative Delirium: The Jury Is Still Out.
Topics: Aged; Anesthesia; Delirium; Dexmedetomidine; Hip Fractures; Humans; Propofol | 2018 |
Late Awakening in Survivors of Postanoxic Coma: Early Neurophysiologic Predictors and Association With ICU and Long-Term Neurologic Recovery.
Topics: Aged; Cohort Studies; Coma; Delirium; Electroencephalography; Evoked Potentials, Motor; Female; Hear | 2019 |
Effect of dexmedetomidine on postoperative delirium in elderly patients undergoing hip fracture surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Aged, 80 and over; Anesthesia, General; Delirium; Dexmed | 2018 |
Trajectory of severity of postoperative delirium symptoms and its prospective association with cognitive function in patients with gastric cancer: results from a prospective observational study.
Topics: Anesthetics, Intravenous; Cognition; Cytoreduction Surgical Procedures; Delirium; Female; Hospitaliz | 2019 |
A novel understanding of postoperative complications: In vitro study of the impact of propofol on epigenetic modifications in cholinergic genes.
Topics: Cell Line, Tumor; Cholinergic Agents; Cholinergic Neurons; Cholinesterases; Delirium; Epigenesis, Ge | 2019 |
Singapore SPICE: sedation practices in intensive care evaluation in Singapore - a prospective cohort study of the public healthcare system.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Cohort Studies; Critical Care; Delirium; F | 2020 |
Current practice and perceptions regarding pain, agitation and delirium management in patients receiving venovenous extracorporeal membrane oxygenation.
Topics: Adult; Analgesics, Opioid; Anesthesia; Anesthetics, Intravenous; Attitude of Health Personnel; Benzo | 2019 |
Intravenous Acetaminophen for Postoperative Delirium.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Delirium; Dexmedetomidine; Humans; Propofol | 2019 |
Intravenous Acetaminophen for Postoperative Delirium-Reply.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Delirium; Dexmedetomidine; Humans; Propofol | 2019 |
Propofol and the risk of delirium: exploring the anticholinergic properties of propofol.
Topics: Anesthetics; Cholinergic Antagonists; Delirium; Humans; Models, Biological; Propofol; Risk Factors | 2013 |
Incidence of postoperative delirium is high even in a population without known risk factors.
Topics: Aged; Anesthesia, General; Anesthetics; Anesthetics, Combined; Delirium; Elective Surgical Procedure | 2014 |
[Prolonged delirium due to propofol sedation in an adolescent].
Topics: Adolescent; Delirium; Humans; Hypnotics and Sedatives; Male; Propofol; Time Factors | 2014 |
Rapidly reversible, sedation-related delirium versus persistent delirium in the intensive care unit.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Conscious Sedation; Critical Care; Delirium; Female; Fen | 2014 |
Rapidly reversible, sedation-related delirium versus persistent delirium in the intensive care unit.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Conscious Sedation; Critical Care; Delirium; Female; Fen | 2014 |
Rapidly reversible, sedation-related delirium versus persistent delirium in the intensive care unit.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Conscious Sedation; Critical Care; Delirium; Female; Fen | 2014 |
Rapidly reversible, sedation-related delirium versus persistent delirium in the intensive care unit.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Conscious Sedation; Critical Care; Delirium; Female; Fen | 2014 |
Of delirium and sedation.
Topics: Conscious Sedation; Delirium; Female; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Care Unit | 2014 |
[Methohexital for analgosedation of ventilated intensive care patients : prospective nonrandomized single center observational study on incidence of delirium].
Topics: Aged; Analgesics, Opioid; Anesthetics, Intravenous; Checklist; Cohort Studies; Critical Care; Deliri | 2014 |
Our enlightened understanding of the risks of persistent delirium.
Topics: Conscious Sedation; Delirium; Female; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Care Unit | 2014 |
Only a small subset of sedation-related delirium is innocuous: we cannot let our guard down.
Topics: Conscious Sedation; Delirium; Female; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Care Unit | 2014 |
Reply: Is the glass of delirium half full or half empty?
Topics: Conscious Sedation; Delirium; Female; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Care Unit | 2014 |
Reply: The importance of determining the reason for intensive care unit delirium.
Topics: Conscious Sedation; Delirium; Female; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Care Unit | 2014 |
Emergence agitation: is there a European consensus?
Topics: Analgesics, Opioid; Anesthesia Recovery Period; Child; Consensus; Delirium; Europe; Humans; Hypnotic | 2014 |
Am I dead? A patient's experience with delirium.
Topics: Conscious Sedation; Critical Care Nursing; Death; Delirium; Female; Humans; Hypnotics and Sedatives; | 2015 |
A web-based survey of United Kingdom sedation practice in the intensive care unit.
Topics: Alfentanil; Analgesics, Opioid; Conscious Sedation; Critical Care; Data Collection; Deep Sedation; D | 2015 |
Emergence delirium in children.
Topics: Anesthesia, General; Delirium; Dexmedetomidine; Female; Humans; Magnetic Resonance Imaging; Male; Pr | 2015 |
Is postoperative delirium a relevant outcome?
Topics: Anesthetics; Delirium; Female; Humans; Male; Postoperative Complications; Propofol; Thiopental | 2016 |
Dexmedetomidine and emergence agitation.
Topics: Anesthesia, General; Delirium; Dexmedetomidine; Female; Humans; Magnetic Resonance Imaging; Male; Pr | 2015 |
A reply.
Topics: Anesthesia, General; Delirium; Dexmedetomidine; Female; Humans; Magnetic Resonance Imaging; Male; Pr | 2015 |
Nocturnal Low-Dose Propofol Infusion for the Management of ICU Delirium: A Case Series in Nonintubated Cardiac Surgery Patients.
Topics: Adult; Aged; Cardiac Surgical Procedures; Critical Care; Delirium; Dose-Response Relationship, Drug; | 2016 |
Current concepts in sedation in the adult ICU.
Topics: Adult; Benzodiazepines; Conscious Sedation; Critical Care; Delirium; Humans; Hypnotics and Sedatives | 2008 |
Prevention of emergence delirium.
Topics: Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; Delirium; Humans; Lar | 2008 |
Identification of predictors of post-ictal delirium after electroconvulsive therapy.
Topics: Adult; Anesthesia, General; Catatonia; Delirium; Depressive Disorder, Major; Electroconvulsive Thera | 2009 |
Emergence delirium after propofol anaesthesia.
Topics: Anesthesia Recovery Period; Anesthetics, Intravenous; Delirium; Female; Humans; Propofol; Young Adul | 2011 |
Experience with a propofol-ketamine mixture for sedation during pediatric orthopedic surgery.
Topics: Adolescent; Anesthesia Recovery Period; Anesthesia, Conduction; Anesthetics, Combined; Anesthetics, | 2010 |
[Influence of general anesthetics on the incidence of postoperative delirium in the elderly].
Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, General; Delirium; Female; Humans; Incide | 2011 |
Opioid-free perioperative analgesia for hemicolectomy in a patient with opioid-induced delirium: a case report and review of the analgesic efficacy of the alpha-2 agonist agents.
Topics: Abdominal Abscess; Adrenergic alpha-2 Receptor Agonists; Analgesia, Epidural; Analgesics, Non-Narcot | 2012 |
Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium.
Topics: Aged; Benzodiazepines; Circadian Rhythm; Clinical Protocols; Coma; Critical Care; Delirium; Dose-Res | 2012 |
Sedative use in the last week of life and the implications for end-of-life decision making.
Topics: Adult; Aged; Anticonvulsants; Decision Making; Delirium; Double Effect Principle; Ethics, Clinical; | 2003 |
Hypnosis first, then dissociation.
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Delirium; Hallucinations; Humans; Hypnosis; Ket | 2003 |
Postoperative mental disorder following prolonged oral surgery.
Topics: Age Factors; Anesthetics, Intravenous; Blood Loss, Surgical; Carcinoma, Squamous Cell; Delirium; Fem | 2004 |
Propofol in the management of postictal delirium with clozapine-electroconvulsive therapy combination.
Topics: Adult; Anesthetics, Intravenous; Antipsychotic Agents; Clozapine; Combined Modality Therapy; Deliriu | 2004 |
Propofol for office oral and maxillofacial anesthesia: the case against low-dose ketamine.
Topics: Ambulatory Surgical Procedures; Anesthesia Recovery Period; Anesthesia, Dental; Anesthetics, Dissoci | 2006 |
Delirium during intravenous sedation with midazolam alone and with propofol in dental treatment.
Topics: Alveolar Ridge Augmentation; Anesthesia, Dental; Anesthetics, Combined; Anesthetics, Intravenous; Co | 2006 |
Quetiapine as treatment for delirium during weaning from ventilation: a case report.
Topics: Acute Disease; Anesthetics, Intravenous; Antipsychotic Agents; Delirium; Diagnostic and Statistical | 2007 |
Propofol in terminal care.
Topics: Delirium; Humans; Hypnotics and Sedatives; Liver Neoplasms; Male; Middle Aged; Myoclonus; Palliative | 1995 |
The use of propofol in palliative medicine.
Topics: Aged; Anesthetics, Intravenous; Delirium; Humans; Hypnotics and Sedatives; Male; Neoplasms; Palliati | 1995 |
Prolonged delirium after propofol.
Topics: Adult; Anesthetics, Intravenous; Delirium; Female; Humans; Propofol | 1996 |