propofol has been researched along with Craniocerebral Injuries in 31 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate changes in serum neuron-specific enolase (NSE) concentration in patients before, during and after surgery for acute craniocerebral trauma, and examine the effects of propofol and isoflurane on these changes." | 9.11 | [Effects of propofol and isoflurane on serum neuron-specific enolase level in surgical patients with acute craniocerebral trauma: a comparative study]. ( Chen, LM; Gan, GS; Qiu, W; Shen, QX; Wang, YL; Yu, JB, 2005) |
| "In order to explore the effects of propofol anesthesia system based on block chain on brain tissue and brain function protection, 88 patients undergoing craniocerebral trauma surgery are selected for prospective study." | 8.12 | A Clinical Study on the Brain Protection Effect of Propofol Anesthesia on Patients Undergoing Acute Craniocerebral Trauma Surgery Based on Blockchain. ( Li, H; Li, J; Ma, D; Su, P; Zhang, J, 2022) |
| "Propofol infusion syndrome (PRIS), a rare complication of propofol sedation, is associated with high mortality." | 7.81 | Therapeutic plasma exchange as treatment for propofol infusion syndrome. ( Levin, PD; Levin, V; Rund, D; Sprung, CL; Weissman, C, 2015) |
| "Propofol infusion syndrome has been increasingly recognized as a syndrome of unexplained myocardial failure, metabolic acidosis, and rhabdomyolysis with renal failure." | 7.72 | Propofol infusion syndrome: an unusual cause of renal failure. ( Casserly, B; Eisele, G; Haqqie, S; O'Mahony, E; Timm, EG; Urizar, R, 2004) |
| "To investigate changes in serum neuron-specific enolase (NSE) concentration in patients before, during and after surgery for acute craniocerebral trauma, and examine the effects of propofol and isoflurane on these changes." | 5.11 | [Effects of propofol and isoflurane on serum neuron-specific enolase level in surgical patients with acute craniocerebral trauma: a comparative study]. ( Chen, LM; Gan, GS; Qiu, W; Shen, QX; Wang, YL; Yu, JB, 2005) |
| "In order to explore the effects of propofol anesthesia system based on block chain on brain tissue and brain function protection, 88 patients undergoing craniocerebral trauma surgery are selected for prospective study." | 4.12 | A Clinical Study on the Brain Protection Effect of Propofol Anesthesia on Patients Undergoing Acute Craniocerebral Trauma Surgery Based on Blockchain. ( Li, H; Li, J; Ma, D; Su, P; Zhang, J, 2022) |
| "Propofol infusion syndrome (PRIS), a rare complication of propofol sedation, is associated with high mortality." | 3.81 | Therapeutic plasma exchange as treatment for propofol infusion syndrome. ( Levin, PD; Levin, V; Rund, D; Sprung, CL; Weissman, C, 2015) |
| "Propofol infusion syndrome has been increasingly recognized as a syndrome of unexplained myocardial failure, metabolic acidosis, and rhabdomyolysis with renal failure." | 3.72 | Propofol infusion syndrome: an unusual cause of renal failure. ( Casserly, B; Eisele, G; Haqqie, S; O'Mahony, E; Timm, EG; Urizar, R, 2004) |
| " After an initial 133Xe cerebral blood flow (CBF) assessment, transcranial Doppler ultrasonography recordings of the middle cerebral arteries were obtained to assess blood flow velocity changes resulting from transient hyperventilation (57 studies in 27 patients), phenylephrine-induced hypertension (55 studies in 26 patients), and propofol-induced metabolic suppression (43 studies in 21 patients)." | 3.71 | Efficacy of hyperventilation, blood pressure elevation, and metabolic suppression therapy in controlling intracranial pressure after head injury. ( Boscardin, WJ; Glenn, TC; Hovda, DA; Kelly, DF; Lee, JH; Martin, NA; McArthur, DL; Oertel, M; Vespa, P, 2002) |
| " The incidence of adverse events during the sedation period was also similar." | 2.69 | Propofol versus midazolam: safety and efficacy for sedating the severe trauma patient. ( Alted-Lopez, E; Ambros-Checa, A; Caballero-Cubedo, RE; Cantalapiedra-Santiago, JA; Perez-Vela, JL; Sanchez-Izquierdo-Riera, JA, 1998) |
| "Traumatic brain injuries remain an area of great challenge to both neurosurgeons and neuroanaesthesiologists." | 2.45 | Traumatic brain injury: neuroprotective anaesthetic techniques, an update. ( Aal-Shaya, WA; Al-Faridi, K; Halawani, MM; Taha, WS; Tawfeeq, NA, 2009) |
| "Propofol is an oil at room temperature and insoluble in aqueous solution." | 2.42 | Propofol: therapeutic indications and side-effects. ( Marik, PE, 2004) |
| "Ketamine has been historically contraindicated for its use in head injury patients, since an increase of intracranial pressure (ICP) was reported; nevertheless, its use was recently suggested in neurosurgical patients." | 1.39 | Racemic ketamine in adult head injury patients: use in endotracheal suctioning. ( Annetta, MG; Antonelli, M; Bocci, MG; Caricato, A; De Waure, C; Pennisi, MA; Pitoni, S; Sandroni, C; Tersali, A, 2013) |
| "We reviewed all patients with severe head trauma admitted to our Neuro-Intensive Care Unit over a 4-year period for use of propofol and vasopressors." | 1.35 | Vasopressors and propofol infusion syndrome in severe head trauma. ( Sinson, G; Smith, H; Varelas, P, 2009) |
| "We studied nine patients with isolated head injuries and 11 multiply injured patients with associated head injuries." | 1.29 | Blood pressure changes in head-injury patients during pre-hospital anaesthesia with propofol. ( Davis, GE; Heath, KJ; Samra, GS; Wilmink, AB; Wilson, AW, 1994) |
| "Propofol was given by continuous intravenous infusion to 10 patients with severe head injuries in the intensive care unit." | 1.28 | Propofol infusion for sedation of patients with head injury in intensive care. A preliminary report. ( Coppel, DL; Farling, PA; Johnston, JR, 1989) |
| "Propofol 2 mg/kg was given intravenously over 90 seconds when the mean intracranial pressure reached or exceeded 25 mmHg." | 1.27 | Effect of propofol on elevated intracranial pressure. Preliminary results. ( Colardyn, F; Herregods, L; Rolly, G; Verbeke, J, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (12.90) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 17 (54.84) | 29.6817 |
| 2010's | 5 (16.13) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Li, J | 1 |
| Su, P | 1 |
| Zhang, J | 1 |
| Ma, D | 1 |
| Roberts, DJ | 1 |
| Faris, PD | 1 |
| Zygun, DA | 1 |
| Caricato, A | 1 |
| Tersali, A | 1 |
| Pitoni, S | 1 |
| De Waure, C | 1 |
| Sandroni, C | 1 |
| Bocci, MG | 1 |
| Annetta, MG | 1 |
| Pennisi, MA | 1 |
| Antonelli, M | 1 |
| Levin, PD | 1 |
| Levin, V | 1 |
| Weissman, C | 1 |
| Sprung, CL | 1 |
| Rund, D | 1 |
| Smith, H | 1 |
| Sinson, G | 1 |
| Varelas, P | 1 |
| Castellani, G | 1 |
| Zweifel, C | 1 |
| Kim, DJ | 1 |
| Carrera, E | 1 |
| Radolovich, DK | 1 |
| Smielewski, P | 1 |
| Hutchinson, PJ | 1 |
| Pickard, JD | 1 |
| Czosnyka, M | 1 |
| Tawfeeq, NA | 1 |
| Halawani, MM | 1 |
| Al-Faridi, K | 1 |
| Aal-Shaya, WA | 1 |
| Taha, WS | 1 |
| Menku, A | 1 |
| Ogden, M | 1 |
| Saraymen, R | 1 |
| Annecke, T | 1 |
| Conzen, P | 1 |
| Ney, L | 1 |
| Oertel, M | 1 |
| Kelly, DF | 3 |
| Lee, JH | 1 |
| McArthur, DL | 1 |
| Glenn, TC | 1 |
| Vespa, P | 1 |
| Boscardin, WJ | 1 |
| Hovda, DA | 1 |
| Martin, NA | 1 |
| Johnston, AJ | 1 |
| Steiner, LA | 1 |
| Chatfield, DA | 1 |
| Coleman, MR | 1 |
| Coles, JP | 1 |
| Al-Rawi, PG | 1 |
| Menon, DK | 2 |
| Gupta, AK | 1 |
| Urwin, SC | 1 |
| Bopp, C | 1 |
| Plachky, J | 1 |
| Hofer, S | 1 |
| Graf, BM | 1 |
| Weigand, MA | 1 |
| Casserly, B | 1 |
| O'Mahony, E | 1 |
| Timm, EG | 1 |
| Haqqie, S | 1 |
| Eisele, G | 1 |
| Urizar, R | 1 |
| Marik, PE | 1 |
| Kondrat'ev, A | 1 |
| Paleĭ, DA | 1 |
| Gan, GS | 1 |
| Wang, YL | 1 |
| Chen, LM | 1 |
| Shen, QX | 1 |
| Yu, JB | 1 |
| Qiu, W | 1 |
| Fodale, V | 1 |
| Pratico, C | 1 |
| Tescione, M | 1 |
| Tanania, S | 1 |
| Lucanto, T | 1 |
| Santamaria, LB | 1 |
| Karakitsos, D | 1 |
| Poularas, J | 1 |
| Kalogeromitros, A | 1 |
| Karabinis, A | 1 |
| Ghori, KA | 1 |
| Harmon, DC | 1 |
| Elashaal, A | 1 |
| Butler, M | 1 |
| Walsh, F | 1 |
| O'Sullivan, MG | 1 |
| Shorten, GD | 1 |
| Heath, KJ | 1 |
| Samra, GS | 1 |
| Davis, GE | 1 |
| Wilmink, AB | 1 |
| Wilson, AW | 1 |
| Sanchez-Izquierdo-Riera, JA | 1 |
| Caballero-Cubedo, RE | 1 |
| Perez-Vela, JL | 1 |
| Ambros-Checa, A | 1 |
| Cantalapiedra-Santiago, JA | 1 |
| Alted-Lopez, E | 1 |
| Holger, JS | 1 |
| Hale, DB | 1 |
| Harris, CR | 1 |
| Solberg, C | 1 |
| Benfante, F | 1 |
| Goodale, DB | 1 |
| Williams, J | 1 |
| Herr, DL | 1 |
| Chappell, ET | 1 |
| Rosner, MJ | 1 |
| Jacobson, J | 1 |
| Levy, ML | 1 |
| Croce, MA | 1 |
| Maniker, AH | 1 |
| Fulda, GJ | 1 |
| Lovett, JV | 1 |
| Mohan, O | 1 |
| Narayan, RK | 1 |
| Myburgh, JA | 1 |
| Upton, RN | 1 |
| Politis, P | 1 |
| Zakynthinos, E | 1 |
| Kotanidou, A | 1 |
| Andrianakis, I | 1 |
| Roussos, C | 1 |
| Lelausque, JN | 1 |
| Lemeur, F | 1 |
| Pinaud, M | 1 |
| Souron, R | 1 |
| Farling, PA | 1 |
| Johnston, JR | 1 |
| Coppel, DL | 1 |
| Herregods, L | 1 |
| Verbeke, J | 1 |
| Rolly, G | 1 |
| Colardyn, F | 1 |
| Mangez, JF | 1 |
| Menguy, E | 1 |
| Roux, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Large Antecubital Vein Versus Small Vein on Dorsum of Hand for the Prevention of Propofol Injection Pain[NCT04673500] | 160 participants (Actual) | Interventional | 2013-05-31 | Completed | |||
| A Multi-center, Double-blind, Randomized, Controlled Study to Determine the Efficacy and Safety of a New Formulation of Acetylcysteine Injection[NCT01118663] | Phase 3 | 17 participants (Actual) | Interventional | 2010-09-30 | Terminated | ||
| Comparison Between Ondansetron 8 mg and Lidocain 40 mg in Preventing Pain Due to Propofol Injection[NCT03134612] | Phase 2 | 104 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Data analysis was conducted on the subjects enrolled in the study prior to study termination. Because the study was terminated prematurely due to lack of enrollment, there was an insufficient sample size to conduct an efficacy analysis. (NCT01118663)
Timeframe: 1 hour
| Intervention | participants (Number) |
|---|---|
| Acetadote Without EDTA | 0 |
| Acetadote | 1 |
(NCT01118663)
Timeframe: 21-42 hours
| Intervention | Number of Events (Number) |
|---|---|
| Acetadote Without EDTA | 13 |
| Acetadote | 14 |
3 reviews available for propofol and Craniocerebral Injuries
| Article | Year |
|---|---|
Traumatic brain injury: neuroprotective anaesthetic techniques, an update.
Topics: Adolescent; Adult; Brain Injuries; Cell Death; Central Nervous System Depressants; Craniocerebral Tr | 2009 |
Comparative tolerability of sedative agents in head-injured adults.
Topics: Antipsychotic Agents; Barbiturates; Benzodiazepines; Craniocerebral Trauma; Drug Tolerance; Etomidat | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
5 trials available for propofol and Craniocerebral Injuries
| Article | Year |
|---|---|
[Effects of propofol and isoflurane on serum neuron-specific enolase level in surgical patients with acute craniocerebral trauma: a comparative study].
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Craniocerebral Trauma; Female; Humans; Isoflurane | 2005 |
Effect of midazolam versus propofol sedation on markers of neurological injury and outcome after isolated severe head injury: a pilot study.
Topics: Adolescent; Adult; Aged; Biomarkers; Craniocerebral Trauma; Double-Blind Method; Female; Glasgow Out | 2007 |
Propofol versus midazolam: safety and efficacy for sedating the severe trauma patient.
Topics: Adult; Analgesics, Opioid; Anesthesia Recovery Period; Blood Pressure; Brain; Craniocerebral Trauma; | 1998 |
Sedation of intoxicated, agitated patients requiring CT to evaluate head injury.
Topics: Adolescent; Adult; Aged; Alcoholic Intoxication; Craniocerebral Trauma; Female; Humans; Hypnotics an | 1999 |
Propofol in the treatment of moderate and severe head injury: a randomized, prospective double-blinded pilot trial.
Topics: Adult; Blood Pressure; Cause of Death; Cerebrovascular Circulation; Craniocerebral Trauma; Dose-Resp | 1999 |
23 other studies available for propofol and Craniocerebral Injuries
| Article | Year |
|---|---|
A Clinical Study on the Brain Protection Effect of Propofol Anesthesia on Patients Undergoing Acute Craniocerebral Trauma Surgery Based on Blockchain.
Topics: Anesthesia; Anesthetics; Blockchain; Brain; Craniocerebral Trauma; Humans; Propofol; Prospective Stu | 2022 |
Propofol for severe traumatic brain injury.
Topics: Craniocerebral Trauma; Female; Humans; Hypnotics and Sedatives; Male; Propofol | 2014 |
Racemic ketamine in adult head injury patients: use in endotracheal suctioning.
Topics: Adult; Anesthetics, Dissociative; Craniocerebral Trauma; Hemodynamics; Humans; Hypnotics and Sedativ | 2013 |
Therapeutic plasma exchange as treatment for propofol infusion syndrome.
Topics: Accidents, Traffic; Acidosis, Lactic; Acute Kidney Injury; Adolescent; Anticonvulsants; Biomarkers; | 2015 |
Vasopressors and propofol infusion syndrome in severe head trauma.
Topics: Acidosis; Adult; Aged; Aged, 80 and over; Combined Modality Therapy; Craniocerebral Trauma; Creatine | 2009 |
Plateau waves in head injured patients requiring neurocritical care.
Topics: Adult; Blood Pressure; Cerebrovascular Circulation; Craniocerebral Trauma; Critical Care; Heart Rate | 2009 |
The protective effects of propofol and citicoline combination in experimental head injury in rats.
Topics: Animals; Blood Pressure; Craniocerebral Trauma; Cytidine Diphosphate Choline; Disease Models, Animal | 2010 |
Propofol-related infusion syndrome induced by "moderate dosage" in a patient with severe head trauma.
Topics: Acidosis; Adult; Anesthetics, Intravenous; Craniocerebral Trauma; Dose-Response Relationship, Drug; | 2012 |
Efficacy of hyperventilation, blood pressure elevation, and metabolic suppression therapy in controlling intracranial pressure after head injury.
Topics: Adult; Blood Pressure; Brain; Cohort Studies; Craniocerebral Trauma; Female; Humans; Hyperventilatio | 2002 |
Effects of propofol on cerebral oxygenation and metabolism after head injury.
Topics: Adult; Anesthetics, Intravenous; Brain; Cerebrovascular Circulation; Craniocerebral Trauma; Electroe | 2003 |
[Anesthesia and intensive care medicine--status report. XIIIth International Symposium on Anesthesia in Heidelberg, March 19-21, 2004].
Topics: Anesthesia; Anesthesia, Conduction; Anesthesiology; Anesthetics, Intravenous; Blood Transfusion; Car | 2004 |
Propofol infusion syndrome: an unusual cause of renal failure.
Topics: Acidosis; Acute Kidney Injury; Adolescent; Adult; Craniocerebral Trauma; Female; Humans; Infusions, | 2004 |
[Hemodynamic reaction attended safety in severe head injury patients at different periods of operative treatment].
Topics: Analgesics; Anesthetics, Combined; Anesthetics, Intravenous; Blood Circulation; Clonidine; Craniocer | 2005 |
Evidence of acute tolerance to remifentanil in intensive care but not in anesthesia.
Topics: Adjuvants, Anesthesia; Adult; Analgesics, Opioid; Anesthesia, General; Anesthetics, Inhalation; Cran | 2006 |
The propofol infusion syndrome treated with haemofiltration. Is there a time for genetic screening?
Topics: Adult; Anesthesia, Intravenous; Craniocerebral Trauma; Female; Genetic Testing; Hemofiltration; Huma | 2007 |
Blood pressure changes in head-injury patients during pre-hospital anaesthesia with propofol.
Topics: Blood Pressure; Craniocerebral Trauma; Emergency Medical Services; Humans; Intubation, Intratracheal | 1994 |
Propofol use in head-injury patients.
Topics: Acidosis; Adolescent; Adult; Anesthetics, Intravenous; Animals; Cardiac Output; Craniocerebral Traum | 2001 |
Propofol use in head-injury patients.
Topics: Adolescent; Adult; Age Factors; Anesthetics, Intravenous; Arrhythmias, Cardiac; Cause of Death; Cere | 2001 |
Propofol-infusion syndrome.
Topics: Acidosis; Adult; Craniocerebral Trauma; Fatal Outcome; Humans; Hypnotics and Sedatives; Propofol | 2001 |
[The effects of propofol (Diprivan) on cerebral circulation, intracranial pressure and cerebral metabolism in cranial trauma].
Topics: Adolescent; Adult; Brain Chemistry; Cerebrovascular Circulation; Craniocerebral Trauma; Humans; Intr | 1989 |
Propofol infusion for sedation of patients with head injury in intensive care. A preliminary report.
Topics: Adolescent; Adult; Craniocerebral Trauma; Critical Care; Female; Hemodynamics; Humans; Hypnotics and | 1989 |
Effect of propofol on elevated intracranial pressure. Preliminary results.
Topics: Adult; Anesthetics; Cerebrovascular Circulation; Craniocerebral Trauma; Female; Hemodynamics; Humans | 1988 |
[Sedation by constant-rate propofol in the head-injured patient. Preliminary results].
Topics: Anesthetics; Craniocerebral Trauma; Humans; Infusions, Intravenous; Intracranial Pressure; Phenols; | 1987 |