propofol has been researched along with Cognitive Decline in 44 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The objective was to determine whether administering remifentanil-propofol combined with dexmedetomidine during general anesthesia would decrease the incidence and severity of postoperative emergence agitation, anxiety, and depression without affecting cognitive dysfunction in elderly patients." | 9.51 | The effects of remifentanil-propofol combined with dexmedetomidine on cognitive dysfunction in elderly patients after ureteroscopic holmium laser lithotripsy: a double-blind randomized controlled trial. ( Gao, XP; Wang, F; Wu, L; Xie, D; Xu, H; Ye, Q, 2022) |
| "Elderly patients undergoing laparoscopic cholecystectomy were randomly assigned to receive propofol, sevoflurane, or isoflurane anesthesia." | 9.24 | Effect of propofol, sevoflurane, and isoflurane on postoperative cognitive dysfunction following laparoscopic cholecystectomy in elderly patients: A randomized controlled trial. ( Geng, YJ; Wu, QH; Zhang, RQ, 2017) |
| " One patient in the propofol group developed delirium compared to zero in desflurane." | 9.24 | The effect of desflurane versus propofol anesthesia on postoperative delirium in elderly obese patients undergoing total knee replacement: A randomized, controlled, double-blinded clinical trial. ( Goodman, S; Huddleston, J; Lemmens, HJ; Maloney, W; Sommer, BR; Tanaka, P, 2017) |
| " Compared to isoflurane anesthesia, propofol anesthesia exhibited less effect on spatial learning and memory of rats with cardiac surgery and contributed to a relative reduction in activated microglia in the hippocampus, a notable increase in miR-223-3p expression, and a decrease in inflammation." | 8.12 | Propofol alleviates postoperative cognitive dysfunction by inhibiting inflammation via up-regulating miR-223-3p in aged rats. ( Cao, C; Deng, F; Lian, F; Liu, C; Zhou, Z, 2022) |
| "The aim of this study was to evaluate the effect of minocycline preadministration on cognitive dysfunction, hippocampal inflammatory response, and hippocampal senile dementia-related proteins induced by propofol anesthesia in aged rats." | 8.12 | Effects of Minocycline on Cognitive Impairment, Hippocampal Inflammatory Response, and Hippocampal Alzheimer's Related Proteins in Aged Rats after Propofol Anesthesia. ( Liang, X; Zhang, R, 2022) |
| "Propofol-induced cognitive dysfunction in rats may be related to the hyperphosphorylation of Tau that causes neuronal cells to re-enter the cell cycle, thus leading to apoptosis." | 7.88 | Hyperphosphorylation of protein Tau in hippocampus may cause cognitive dysfunction of propofol-anesthetized rats. ( Fan, YY; Fu, YT; Sun, LH; Wang, G; Yang, TW; Zheng, HB, 2018) |
| "Cognitive dysfunction is a severe issue of Alzheimer's disease." | 5.91 | Propofol protects rats against intra-cerebroventricular streptozotocin-induced cognitive dysfunction and neuronal damage. ( Dou, X; Sun, L; Yang, W, 2023) |
| " The objective was to determine whether administering remifentanil-propofol combined with dexmedetomidine during general anesthesia would decrease the incidence and severity of postoperative emergence agitation, anxiety, and depression without affecting cognitive dysfunction in elderly patients." | 5.51 | The effects of remifentanil-propofol combined with dexmedetomidine on cognitive dysfunction in elderly patients after ureteroscopic holmium laser lithotripsy: a double-blind randomized controlled trial. ( Gao, XP; Wang, F; Wu, L; Xie, D; Xu, H; Ye, Q, 2022) |
| "Propofol was injected for anesthesia (n = 22)." | 5.48 | The recovery from transient cognitive dysfunction induced by propofol was associated with enhanced autophagic flux in normal healthy adult mice. ( Baik, HJ; Cho, S; Han, JI; Jung, YJ; Lee, GY; Lee, KE; Suh, EC, 2018) |
| "To investigate the effects of propofol combined with hypoxia on cognitive function of immature rats and the possible role of p38 pathway and tau protein in mediating such effects." | 5.48 | [Propofol combined with hypoxia induces cognitive dysfunction in immature rats ( Liu, H; Liu, Y; Sun, M; Tian, Q; Tu, S; Yu, Q; Zhang, J, 2018) |
| "The oleuropein-pretreated groups received oleuropein (15 mg/kg body weight as orally) for 10 consecutive days." | 5.46 | Oleuropein attenuates cognitive dysfunction and oxidative stress induced by some anesthetic drugs in the hippocampal area of rats. ( Alirezaei, M; Hajighahramani, S; Kiani, K; Rezaei, M; Sookhtehzari, A, 2017) |
| " Sedation with dexmedetomidine may reduce postoperative delirium (POD)." | 5.27 | Intraoperative Sedation With Dexmedetomidine is Superior to Propofol for Elderly Patients Undergoing Hip Arthroplasty: A Prospective Randomized Controlled Study. ( Chen, S; Cheng, X; Gu, E; Liu, X; Mei, B; Meng, G; Xu, G; Zhang, M; Zhang, Y, 2018) |
| "Elderly patients undergoing laparoscopic cholecystectomy were randomly assigned to receive propofol, sevoflurane, or isoflurane anesthesia." | 5.24 | Effect of propofol, sevoflurane, and isoflurane on postoperative cognitive dysfunction following laparoscopic cholecystectomy in elderly patients: A randomized controlled trial. ( Geng, YJ; Wu, QH; Zhang, RQ, 2017) |
| " One patient in the propofol group developed delirium compared to zero in desflurane." | 5.24 | The effect of desflurane versus propofol anesthesia on postoperative delirium in elderly obese patients undergoing total knee replacement: A randomized, controlled, double-blinded clinical trial. ( Goodman, S; Huddleston, J; Lemmens, HJ; Maloney, W; Sommer, BR; Tanaka, P, 2017) |
| "To determine the effect of choice of inhalational anaesthetic (sevoflurane vs propofol) on the incidence and severity of postoperative cognitive dysfunction (POCD) in elderly patients (aged ≥ 60 years) with mild cognitive impairment (MCI)." | 5.19 | Effect of inhalational anaesthetic on postoperative cognitive dysfunction following radical rectal resection in elderly patients with mild cognitive impairment. ( Bai, Y; Liu, Y; Ou, C; Tang, N; Zuo, Y, 2014) |
| " The aging rat model was established by continuous 200 mg/kg propofol anesthesia." | 4.31 | Avenanthramide-C Activates Nrf2/ARE Pathway and Inhibiting Ferroptosis Pathway to Improve Cognitive Dysfunction in Aging Rats. ( Cao, X; Ma, Y; Ma, Z; Song, T; Zhang, Y, 2023) |
| " Compared to isoflurane anesthesia, propofol anesthesia exhibited less effect on spatial learning and memory of rats with cardiac surgery and contributed to a relative reduction in activated microglia in the hippocampus, a notable increase in miR-223-3p expression, and a decrease in inflammation." | 4.12 | Propofol alleviates postoperative cognitive dysfunction by inhibiting inflammation via up-regulating miR-223-3p in aged rats. ( Cao, C; Deng, F; Lian, F; Liu, C; Zhou, Z, 2022) |
| "The aim of this study was to evaluate the effect of minocycline preadministration on cognitive dysfunction, hippocampal inflammatory response, and hippocampal senile dementia-related proteins induced by propofol anesthesia in aged rats." | 4.12 | Effects of Minocycline on Cognitive Impairment, Hippocampal Inflammatory Response, and Hippocampal Alzheimer's Related Proteins in Aged Rats after Propofol Anesthesia. ( Liang, X; Zhang, R, 2022) |
| "Propofol-induced cognitive dysfunction in rats may be related to the hyperphosphorylation of Tau that causes neuronal cells to re-enter the cell cycle, thus leading to apoptosis." | 3.88 | Hyperphosphorylation of protein Tau in hippocampus may cause cognitive dysfunction of propofol-anesthetized rats. ( Fan, YY; Fu, YT; Sun, LH; Wang, G; Yang, TW; Zheng, HB, 2018) |
| "The propofol was used for maintenance during the operation." | 2.84 | Evaluation of the postoperative cognitive dysfunction in elderly patients with general anesthesia. ( Chi, YL; Li, ZS; Lin, CS; Wang, Q; Zhou, YK, 2017) |
| "Propofol-alfentanil has a less negative effect on cognitive functions than propofol alone or propofol-fentanyl." | 2.84 | Effects of alfentanil or fentanyl added to propofol for sedation in colonoscopy on cognitive functions: Randomized controlled trial. ( Doğanay, G; Ekmekçi, P; Erkan, G; Kazbek, BK; Tüzüner, F; Yılmaz, H, 2017) |
| "Propofol has a more significant adverse effect on postoperative cognitive function in elderly patients with lung cancer than sevoflurane." | 2.61 | A systematic review: comparative analysis of the effects of propofol and sevoflurane on postoperative cognitive function in elderly patients with lung cancer. ( Ai, B; Kong, X; Lee, WT; Sun, H; Sun, L; Yan, T; Zhang, G; Zhang, H; Zheng, H, 2019) |
| "Cognitive dysfunction is a severe issue of Alzheimer's disease." | 1.91 | Propofol protects rats against intra-cerebroventricular streptozotocin-induced cognitive dysfunction and neuronal damage. ( Dou, X; Sun, L; Yang, W, 2023) |
| " The purpose of this study was to identify the factors and procedure time associated with the use of intravenous sedation with propofol alone or propofol combined with midazolam in dental patients with special needs." | 1.62 | A comparative study of propofol alone and propofol combined with midazolam for dental treatments in special needs patients. ( Chen, SL; Chong, SY; Huang, MS; Huang, TS; Lin, IH; Tsai, HH; Wang, PY, 2021) |
| "Propofol was added intraperitoneally to the mice from 7th day of insulin/saline treatment, and general anesthesia was induced and maintained for 2 hours/day for 5 consecutive days." | 1.51 | Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice. ( Huang, F; Ke, D; Li, X; Liang, Z; Liu, R; Run, X; Wang, JZ; Wang, Q; Wang, X; Wei, Z; Zeng, K; Zhang, B, 2019) |
| " Then, we found that a single injection of propofol with the sub-anesthetic dosage (50 mg/kg) but not the anesthetic dosage (250 mg/kg) could significantly alleviate the cisplatin-induced memory impairment." | 1.51 | Propofol alleviates cisplatin-related cognitive impairment. ( Qiu, Y; Zhou, Y, 2019) |
| "Propofol was injected for anesthesia (n = 22)." | 1.48 | The recovery from transient cognitive dysfunction induced by propofol was associated with enhanced autophagic flux in normal healthy adult mice. ( Baik, HJ; Cho, S; Han, JI; Jung, YJ; Lee, GY; Lee, KE; Suh, EC, 2018) |
| "To investigate the effects of propofol combined with hypoxia on cognitive function of immature rats and the possible role of p38 pathway and tau protein in mediating such effects." | 1.48 | [Propofol combined with hypoxia induces cognitive dysfunction in immature rats ( Liu, H; Liu, Y; Sun, M; Tian, Q; Tu, S; Yu, Q; Zhang, J, 2018) |
| "The oleuropein-pretreated groups received oleuropein (15 mg/kg body weight as orally) for 10 consecutive days." | 1.46 | Oleuropein attenuates cognitive dysfunction and oxidative stress induced by some anesthetic drugs in the hippocampal area of rats. ( Alirezaei, M; Hajighahramani, S; Kiani, K; Rezaei, M; Sookhtehzari, A, 2017) |
| "After 36 days, the rats with mild cognitive impairment were randomly divided into 4 groups (n=18)." | 1.43 | [Effect of sub-anesthetic doses of isoflurane and propofol on postoperative cognition and underlying mechanism in rats with mild cognitive impairment]. ( Liu, SY; Wang, GL; Wang, HB; Wang, HY, 2016) |
| "Propofol (30 mg/kg) was intraperiotoneally administered to 7‑day‑old Sprague Dawley rats (n=75) three times each day at 90 min intervals for seven consecutive days with or without Dex (75 µg/kg) treatment 20 min prior to propofol injection." | 1.43 | Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats. ( Guo, X; Han, B; Mao, M; Wang, J; Wang, Y; Wu, C; Xu, F, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 28 (63.64) | 24.3611 |
| 2020's | 16 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Shen, M | 1 |
| Lian, N | 1 |
| Song, C | 1 |
| Qin, C | 1 |
| Yu, Y | 2 |
| Lian, F | 1 |
| Cao, C | 1 |
| Deng, F | 1 |
| Liu, C | 1 |
| Zhou, Z | 1 |
| Ma, LH | 1 |
| Wan, J | 1 |
| Yan, J | 1 |
| Wang, N | 2 |
| Liu, YP | 1 |
| Wang, HB | 2 |
| Zhou, CH | 1 |
| Wu, YQ | 1 |
| Wang, F | 2 |
| Xie, D | 1 |
| Xu, H | 1 |
| Ye, Q | 1 |
| Wu, L | 1 |
| Gao, XP | 1 |
| Sun, L | 2 |
| Dou, X | 1 |
| Yang, W | 1 |
| Liang, X | 1 |
| Zhang, R | 1 |
| Liu, P | 1 |
| Zhao, S | 1 |
| Qiao, H | 1 |
| Li, T | 1 |
| Mi, W | 1 |
| Xu, Z | 1 |
| Xue, X | 1 |
| Yan, Y | 1 |
| Logan, S | 1 |
| Liu, X | 2 |
| Chen, B | 1 |
| Jiang, C | 1 |
| Arzua, T | 1 |
| Ramchandran, R | 1 |
| Liu, QS | 1 |
| Bai, X | 1 |
| Ma, Z | 1 |
| Ma, Y | 3 |
| Cao, X | 1 |
| Zhang, Y | 3 |
| Song, T | 1 |
| Zhang, J | 3 |
| Li, Y | 2 |
| Kochetkova, MV | 1 |
| Soluyanov, MY | 1 |
| Khabarov, DV | 1 |
| Demura, AY | 1 |
| Syutkina, IP | 1 |
| Smagin, AA | 1 |
| Sun, H | 1 |
| Zhang, G | 1 |
| Ai, B | 1 |
| Zhang, H | 1 |
| Kong, X | 1 |
| Lee, WT | 1 |
| Zheng, H | 2 |
| Yan, T | 2 |
| Sieber, F | 1 |
| Neufeld, K | 1 |
| Oh, ES | 1 |
| Gottschalk, A | 1 |
| Wang, NY | 1 |
| Nie, Y | 1 |
| Li, S | 1 |
| Ni, C | 2 |
| Wang, H | 1 |
| Li, J | 3 |
| Wu, G | 1 |
| Song, W | 1 |
| Liu, Y | 7 |
| Han, Z | 1 |
| Shen, Z | 1 |
| Zhang, L | 1 |
| Zhou, Q | 1 |
| Zhou, CL | 1 |
| Lin, IH | 1 |
| Huang, MS | 1 |
| Wang, PY | 1 |
| Huang, TS | 1 |
| Chong, SY | 1 |
| Chen, SL | 1 |
| Tsai, HH | 1 |
| Geng, YJ | 1 |
| Wu, QH | 1 |
| Zhang, RQ | 1 |
| Chi, YL | 1 |
| Li, ZS | 1 |
| Lin, CS | 1 |
| Wang, Q | 2 |
| Zhou, YK | 1 |
| Yang, N | 1 |
| Li, L | 1 |
| Li, Z | 1 |
| Cao, Y | 1 |
| Liu, T | 1 |
| Tian, M | 1 |
| Chui, D | 1 |
| Guo, X | 2 |
| Tanaka, P | 1 |
| Goodman, S | 1 |
| Sommer, BR | 1 |
| Maloney, W | 1 |
| Huddleston, J | 1 |
| Lemmens, HJ | 1 |
| Zhang, Q | 1 |
| Li, YN | 1 |
| Guo, YY | 1 |
| Yin, CP | 1 |
| Gao, F | 1 |
| Xin, X | 1 |
| Huo, SP | 1 |
| Wang, XL | 1 |
| Wang, QJ | 1 |
| Cao, YH | 1 |
| Chi, P | 1 |
| Zhao, YX | 1 |
| Dong, XC | 1 |
| Doğanay, G | 1 |
| Ekmekçi, P | 1 |
| Kazbek, BK | 1 |
| Yılmaz, H | 1 |
| Erkan, G | 1 |
| Tüzüner, F | 1 |
| Mei, B | 1 |
| Meng, G | 1 |
| Xu, G | 1 |
| Cheng, X | 1 |
| Chen, S | 1 |
| Zhang, M | 1 |
| Gu, E | 1 |
| Zhou, J | 1 |
| Ma, L | 1 |
| Dong, T | 1 |
| Zhuang, Z | 1 |
| Zheng, HB | 1 |
| Fu, YT | 1 |
| Wang, G | 1 |
| Sun, LH | 1 |
| Fan, YY | 1 |
| Yang, TW | 1 |
| Ren, L | 1 |
| Hao, X | 1 |
| Min, S | 1 |
| Deng, J | 1 |
| Chen, Q | 1 |
| Chen, H | 1 |
| Liu, D | 1 |
| Cho, S | 1 |
| Jung, YJ | 1 |
| Suh, EC | 1 |
| Baik, HJ | 1 |
| Han, JI | 1 |
| Lee, GY | 1 |
| Lee, KE | 1 |
| Shan, GJ | 1 |
| Zhang, YX | 1 |
| Cao, SJ | 1 |
| Zhu, SN | 1 |
| Li, HJ | 1 |
| Ma, D | 1 |
| Wang, DX | 1 |
| Besch, G | 1 |
| Vettoretti, L | 1 |
| Claveau, M | 1 |
| Boichut, N | 1 |
| Mahr, N | 1 |
| Bouhake, Y | 1 |
| Liu, N | 1 |
| Chazot, T | 1 |
| Samain, E | 1 |
| Pili-Floury, S | 1 |
| Zhu, W | 1 |
| Zhang, W | 1 |
| Ding, Z | 1 |
| Huang, Y | 1 |
| Lu, L | 1 |
| Li, X | 2 |
| Run, X | 1 |
| Wei, Z | 1 |
| Zeng, K | 1 |
| Liang, Z | 1 |
| Huang, F | 1 |
| Ke, D | 1 |
| Wang, JZ | 1 |
| Liu, R | 1 |
| Zhang, B | 1 |
| Wang, X | 1 |
| Kletecka, J | 1 |
| Holeckova, I | 1 |
| Brenkus, P | 1 |
| Pouska, J | 1 |
| Benes, J | 1 |
| Chytra, I | 1 |
| Konishi, Y | 1 |
| Evered, LA | 1 |
| Scott, DA | 1 |
| Silbert, BS | 1 |
| Yu, Q | 1 |
| Liu, H | 1 |
| Sun, M | 1 |
| Tian, Q | 1 |
| Tu, S | 1 |
| Wang, W | 1 |
| Liu, F | 1 |
| Li, WX | 1 |
| Luo, RY | 1 |
| Chen, C | 1 |
| Ao, JS | 1 |
| Yin, YQ | 1 |
| Zhou, Y | 1 |
| Qiu, Y | 1 |
| Tang, N | 1 |
| Ou, C | 1 |
| Zuo, Y | 1 |
| Bai, Y | 1 |
| Liu, SY | 1 |
| Wang, HY | 1 |
| Wang, GL | 1 |
| Alirezaei, M | 1 |
| Rezaei, M | 1 |
| Hajighahramani, S | 1 |
| Sookhtehzari, A | 1 |
| Kiani, K | 1 |
| Wang, XJ | 1 |
| Cui, CL | 1 |
| Wu, LZ | 1 |
| Wang, Y | 1 |
| Wu, C | 1 |
| Han, B | 1 |
| Xu, F | 1 |
| Mao, M | 1 |
| Wang, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Electroacupuncture on the Incidence of Postoperative Delirium in Elderly Patients Undergoing the Major Surgery：a Prospective, Multicenter, Double-blind, Randomized Controlled Trial[NCT03606941] | 1,100 participants (Actual) | Interventional | 2018-09-07 | Completed | |||
| Comparison of Postoperative Pain Application of Alfentanil or Remifentanil in TIVA Undergoing Functional Endoscopic Sinus Surgery[NCT05344911] | Phase 4 | 130 participants (Actual) | Interventional | 2022-04-29 | Completed | ||
| Effects of Dexmedetomidine at Different Doses on Hemodynamics and Recovery Quality in Elderly Patients Undergoing Hip Replacement Surgery Under General Anesthesia[NCT05567523] | Phase 4 | 200 participants (Actual) | Interventional | 2019-06-01 | Completed | ||
| Comparison of Propofol and Sevoflurane Anesthesia on the Quality of Recovery After Ambulatory Surgery for Anal Fistula in Obese Patients: A Prospective, Randomized, Single-blinded, Controlled Clinical Trial[NCT05529875] | 0 participants (Actual) | Interventional | 2022-10-31 | Withdrawn (stopped due to In the early stage of the research, this research was limited by the application permission of research drugs and instruments, and the research will have to be interrupted, which is extremely regrettable.) | |||
| Postoperative Cognitive Dysfunction After Intravenous Anesthesia or Closed-loop Coadministration of Propofol and Remifentanil Guided by Bispectral Index for Noncardiac Surgery : a Randomized Monocenter Study[NCT02841423] | 204 participants (Anticipated) | Interventional | 2013-02-28 | Recruiting | |||
| Intranasal Insulin Improves Postoperative Neurocognitive Disorders in Elderly Patients: a Multicenter, Randomized, Double-blind, Placebo-controlled Study[NCT05613491] | 438 participants (Anticipated) | Interventional | 2022-11-07 | Recruiting | |||
| Ketofol vs Dexmedetomidine for Preventing Post-operative Delirium in Elderly Patients Undergoing Intestinal Obstruction Surgeries. A Randomized Controlled Study[NCT04816162] | Phase 4 | 120 participants (Actual) | Interventional | 2021-03-25 | Completed | ||
| The Effects of Different Anesthesia Methods on Perioperative Neurocognitive Disorders in the Elderly: a Randomized Controlled Trial[NCT04488952] | 350 participants (Anticipated) | Interventional | 2020-07-08 | Recruiting | |||
| Impact of Inhalational Versus Intravenous Anesthesia Maintenance Methods on Incidence of Postoperative Delirium in Elderly Patients After Cancer Surgery: An Open-label, Randomized Controlled Trial[NCT02662257] | 1,228 participants (Actual) | Interventional | 2015-04-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for propofol and Cognitive Decline
| Article | Year |
|---|---|
Does propofol definitely improve postoperative cognitive dysfunction?-a review of propofol-related cognitive impairment.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Cognitive Dysfunction; Humans; Postoperative Cogn | 2022 |
Propofol-Induced Developmental Neurotoxicity: From Mechanisms to Therapeutic Strategies.
Topics: Anesthesia, General; Anesthetics, Intravenous; Child; Cognitive Dysfunction; Female; Humans; Infant; | 2023 |
A systematic review: comparative analysis of the effects of propofol and sevoflurane on postoperative cognitive function in elderly patients with lung cancer.
Topics: Age Factors; Aged, 80 and over; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Cogni | 2019 |
13 trials available for propofol and Cognitive Decline
| Article | Year |
|---|---|
The effects of remifentanil-propofol combined with dexmedetomidine on cognitive dysfunction in elderly patients after ureteroscopic holmium laser lithotripsy: a double-blind randomized controlled trial.
Topics: Aged; Cognitive Dysfunction; Dexmedetomidine; Double-Blind Method; Holmium; Humans; Lithotripsy, Las | 2022 |
Effect of baseline cognitive impairment on association between predicted propofol effect site concentration and Bispectral index or sedation score.
Topics: Aged; Aged, 80 and over; Cognitive Dysfunction; Conscious Sedation; Consciousness Monitors; Hip Frac | 2020 |
Effect of propofol, sevoflurane, and isoflurane on postoperative cognitive dysfunction following laparoscopic cholecystectomy in elderly patients: A randomized controlled trial.
Topics: Aged; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarkers; Cholecystectomy, La | 2017 |
Evaluation of the postoperative cognitive dysfunction in elderly patients with general anesthesia.
Topics: Aged; Anesthesia, General; Anesthetics, Intravenous; Cognitive Dysfunction; Humans; Hydrocarbons, Br | 2017 |
The effect of desflurane versus propofol anesthesia on postoperative delirium in elderly obese patients undergoing total knee replacement: A randomized, controlled, double-blinded clinical trial.
Topics: Aged; Anesthesia, General; Arthroplasty, Replacement, Knee; Cognitive Dysfunction; Delirium; Desflur | 2017 |
Effects of preconditioning of electro-acupuncture on postoperative cognitive dysfunction in elderly: A prospective, randomized, controlled trial.
Topics: Aged; Anesthetics, Intravenous; Biomarkers; Cognitive Dysfunction; Electroacupuncture; Female; Human | 2017 |
Effects of alfentanil or fentanyl added to propofol for sedation in colonoscopy on cognitive functions: Randomized controlled trial.
Topics: Adolescent; Adult; Aged; Alfentanil; Cognition; Cognitive Dysfunction; Colonoscopy; Conscious Sedati | 2017 |
Intraoperative Sedation With Dexmedetomidine is Superior to Propofol for Elderly Patients Undergoing Hip Arthroplasty: A Prospective Randomized Controlled Study.
Topics: Aged; Arthroplasty, Replacement, Hip; Cognitive Dysfunction; Delirium; Dexmedetomidine; Female; Huma | 2018 |
Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults.
Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Cog | 2018 |
Early post-operative cognitive dysfunction after closed-loop versus manual target controlled-infusion of propofol and remifentanil in patients undergoing elective major non-cardiac surgery: Protocol of the randomized controlled single-blind POCD-ELA trial
Topics: Aged; Aged, 80 and over; Anesthesia, Closed-Circuit; Anesthetics, Intravenous; Cognitive Dysfunction | 2018 |
Propofol versus sevoflurane anaesthesia: effect on cognitive decline and event-related potentials.
Topics: Adolescent; Adult; Aged; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Cognitive Dy | 2019 |
Effects of propofol, dexmedetomidine, and midazolam on postoperative cognitive dysfunction in elderly patients: a randomized controlled preliminary trial.
Topics: Aged; Cognitive Dysfunction; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Male; Midazol | 2019 |
Effects of propofol, dexmedetomidine, and midazolam on postoperative cognitive dysfunction in elderly patients: a randomized controlled preliminary trial.
Topics: Aged; Cognitive Dysfunction; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Male; Midazol | 2019 |
Effects of propofol, dexmedetomidine, and midazolam on postoperative cognitive dysfunction in elderly patients: a randomized controlled preliminary trial.
Topics: Aged; Cognitive Dysfunction; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Male; Midazol | 2019 |
Effects of propofol, dexmedetomidine, and midazolam on postoperative cognitive dysfunction in elderly patients: a randomized controlled preliminary trial.
Topics: Aged; Cognitive Dysfunction; Dexmedetomidine; Female; Humans; Hypnotics and Sedatives; Male; Midazol | 2019 |
Effect of inhalational anaesthetic on postoperative cognitive dysfunction following radical rectal resection in elderly patients with mild cognitive impairment.
Topics: Administration, Inhalation; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Cognition; Cogn | 2014 |
28 other studies available for propofol and Cognitive Decline
| Article | Year |
|---|---|
Different Anesthetic Drugs Mediate Changes in Neuroplasticity During Cognitive Impairment in Sleep-Deprived Rats via Different Factors.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Cognitive Dysfunction; Disease Models, A | 2021 |
Propofol alleviates postoperative cognitive dysfunction by inhibiting inflammation via up-regulating miR-223-3p in aged rats.
Topics: Animals; Cognitive Dysfunction; Humans; Inflammation; Isoflurane; MicroRNAs; Postoperative Cognitive | 2022 |
Hippocampal SIRT1-Mediated Synaptic Plasticity and Glutamatergic Neuronal Excitability Are Involved in Prolonged Cognitive Dysfunction of Neonatal Rats Exposed to Propofol.
Topics: Animals; Animals, Newborn; Cognitive Dysfunction; Hippocampus; Maze Learning; Neuronal Plasticity; N | 2022 |
Propofol protects rats against intra-cerebroventricular streptozotocin-induced cognitive dysfunction and neuronal damage.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholinesterase; Animals; Cognitive Dysfunction; Dopamine; Hipp | 2023 |
Effects of Minocycline on Cognitive Impairment, Hippocampal Inflammatory Response, and Hippocampal Alzheimer's Related Proteins in Aged Rats after Propofol Anesthesia.
Topics: Alzheimer Disease; Anesthesia; Animals; Cognitive Dysfunction; Glycogen Synthase Kinase 3 beta; Hipp | 2022 |
Integrated Excitatory/Inhibitory Imbalance and Transcriptomic Analysis Reveals the Association between Dysregulated Synaptic Genes and Anesthetic-Induced Cognitive Dysfunction.
Topics: Anesthetics; Animals; Cognitive Dysfunction; Hippocampus; Humans; Mice; Propofol; Transcriptome | 2022 |
Avenanthramide-C Activates Nrf2/ARE Pathway and Inhibiting Ferroptosis Pathway to Improve Cognitive Dysfunction in Aging Rats.
Topics: Aging; Animals; Cognitive Dysfunction; Ferroptosis; Hippocampus; Neuroinflammatory Diseases; NF-E2-R | 2023 |
[Specialty of cognitive impairments in geriatric patients in urological practice.]
Topics: Aged; Anesthesia; Anesthesiology; Cognitive Dysfunction; Humans; Male; Propofol; Prospective Studies | 2023 |
Propofol Attenuates Isoflurane-Induced Neurotoxicity and Cognitive Impairment in Fetal and Offspring Mice.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Animals, Newborn; Brain Chemistry; CA1 R | 2020 |
Prophylactic Melatonin Treatment Ameliorated Propofol-Induced Cognitive Dysfunction in Aged Rats.
Topics: Age Factors; Animals; Behavior, Animal; Cells, Cultured; Cognitive Dysfunction; Hippocampus; Male; M | 2021 |
RTA-408 protects against propofol-induced cognitive impairment in neonatal mice via the activation of Nrf2 and the inhibition of NF-κB p65 nuclear translocation.
Topics: Animals; Animals, Newborn; Cognitive Dysfunction; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; | 2021 |
A comparative study of propofol alone and propofol combined with midazolam for dental treatments in special needs patients.
Topics: Adjuvants, Anesthesia; Administration, Intravenous; Adolescent; Adult; Affective Symptoms; Child; Co | 2021 |
Protective effect of dapsone on cognitive impairment induced by propofol involves hippocampal autophagy.
Topics: Anesthetics, Intravenous; Animals; Autophagy; Cognitive Dysfunction; Dapsone; Hippocampus; Learning; | 2017 |
Effect of bispectral index-guided anesthesia on consumption of anesthetics and early postoperative cognitive dysfunction after liver transplantation: An observational study.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Cognitive Dysfunction; Female; Humans; Liver Tran | 2017 |
The interplay of BDNF-TrkB with NMDA receptor in propofol-induced cognition dysfunction : Mechanism for the effects of propofol on cognitive function.
Topics: Animals; Behavior, Animal; Blotting, Western; Brain-Derived Neurotrophic Factor; Cognitive Dysfuncti | 2018 |
Hyperphosphorylation of protein Tau in hippocampus may cause cognitive dysfunction of propofol-anesthetized rats.
Topics: Anesthetics, Intravenous; Animals; Caspase 3; Cognitive Dysfunction; Cyclin D1; Glycogen Synthase Ki | 2018 |
Anesthetics alleviate learning and memory impairment induced by electroconvulsive shock by regulation of NMDA receptor-mediated metaplasticity in depressive rats.
Topics: Anesthetics; Animals; Behavior, Animal; Cognitive Dysfunction; Depression; Disease Models, Animal; E | 2018 |
The recovery from transient cognitive dysfunction induced by propofol was associated with enhanced autophagic flux in normal healthy adult mice.
Topics: Anesthetics, Intravenous; Animals; Autophagy; Cognition; Cognitive Dysfunction; Disease Models, Anim | 2018 |
The abuse of anesthetic propofol: associated with cognitive impairment.
Topics: Anesthetics; Animals; Cognitive Dysfunction; Humans; Models, Biological; Propofol; Signal Transducti | 2018 |
Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice.
Topics: Administration, Intranasal; Aging; Anesthesia; Anesthetics, Intravenous; Animals; Brain; Cognitive D | 2019 |
Postoperative cognitive dysfunction after sevoflurane or propofol general anaesthesia in combination with spinal anaesthesia for hip arthroplasty.
Topics: Aged; Anesthesia, General; Anesthesia, Spinal; Anesthetics, Inhalation; Anesthetics, Intravenous; Ar | 2018 |
[Propofol combined with hypoxia induces cognitive dysfunction in immature rats
Topics: Animals; Cognitive Dysfunction; Hippocampus; Hypnotics and Sedatives; Hypoxia, Brain; MAP Kinase Sig | 2018 |
Comparison of Cognitive Impairments After Intensive Care Unit Sedation Using Dexmedetomidine and Propofol Among Older Patients.
Topics: Aged; Aged, 80 and over; Anesthesia; Cognition; Cognitive Dysfunction; Cohort Studies; Dexmedetomidi | 2019 |
Propofol alleviates cisplatin-related cognitive impairment.
Topics: Anesthetics, Intravenous; Animals; Antineoplastic Agents; Cisplatin; Cognitive Dysfunction; Female; | 2019 |
[Effect of sub-anesthetic doses of isoflurane and propofol on postoperative cognition and underlying mechanism in rats with mild cognitive impairment].
Topics: Anesthetics; Animals; Apoptosis; Cognition; Cognitive Dysfunction; Hippocampus; Humans; Isoflurane; | 2016 |
Oleuropein attenuates cognitive dysfunction and oxidative stress induced by some anesthetic drugs in the hippocampal area of rats.
Topics: Anesthetics; Animals; Antioxidants; Catalase; Cognitive Dysfunction; Glutathione Peroxidase; Hippoca | 2017 |
Electroacupuncture Ameliorates Propofol-Induced Cognitive Impairment via an Opioid Receptor-Independent Mechanism.
Topics: Anesthetics, Intravenous; Animals; Cognitive Dysfunction; Electroacupuncture; Female; Glycogen Synth | 2016 |
Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats.
Topics: Analgesics; Animals; Apoptosis; bcl-2-Associated X Protein; Biomarkers; Blood Gas Analysis; Caspase | 2016 |