propofol has been researched along with Chronic Lung Injury in 12 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Secondary outcomes included lung inflammation defined as changes in other biomarkers and postoperative pulmonary complications." | 3.11 | Anesthetics to Prevent Lung Injury in Cardiac Surgery: A Randomized Controlled Trial. ( Baedorf Kassis, EN; Banner-Goodspeed, VM; Beydoun, N; Bose, S; Gasangwa, DV; Gosling, AF; Khabbaz, K; Kumaresan, A; Mahmood, FU; Mueller, AL; Novack, V; O'Gara, BP; Patxot, M; Sagy, I; Shaefi, S; Shapeton, A; Spear, K; Subramaniam, B; Talmor, DS, 2022) |
| "MM-S increased significantly after lung injury only in the lavage group, whereas MM-VD increased significantly in both groups." | 1.51 | Near-real-time pulmonary shunt and dead space measurement with micropore membrane inlet mass spectrometry in pigs with induced pulmonary embolism or acute lung failure. ( Eberle, B; Gerber, D; Hartwich, V; Schär, MY; Varadarajan, B; Vasireddy, R; Vogt, A, 2019) |
| "Propofol treatment alleviated intestinal and lung morphological changes which were observed in II/R group，Moreover, wet/dry weight ratio, the MDA level, MPO activity and expression of caspase-3 were significantly decreased whereas the SOD activity and p-Akt expression were significantly increased." | 1.51 | The role of PI3K/Akt signal pathway in the protective effects of propofol on intestinal and lung injury induced by intestinal ischemia/reperfusion1. ( Cui, S; Ding, H; He, X; Jing, G; Li, Q; Xia, Z, 2019) |
| "Propofol has protective effects against IR-induced lung injury by improving activity of oxygen radical and restoring NO/ET-1 dynamic balance." | 1.40 | The significance and mechanism of propofol on treatment of ischemia reperfusion induced lung injury in rats. ( Xu, X; Yang, N; Yang, P; Zhang, X, 2014) |
| "Propofol is an anesthetic drug with antioxidant and anti-inflammatory properties." | 1.39 | Propofol attenuates pulmonary injury induced by collapse and reventilation of lung in rabbits. ( Bae, HB; Chung, SS; Jeong, CW; Kim, HS; Kim, SJ; Kwak, SH; Lee, SH; Li, M, 2013) |
| "ICAM-1 plays an important role in lung injury after intestinal I/R." | 1.33 | [Propofol reduces intercellular adhesion molecular-1 expression in lung injury following intestinal ischemia/reperfusion in rats]. ( Hu, XM; Lu, Y; Yao, SL, 2005) |
| "And it increased W/D ratio of lung, lung injury score and leukocyte count, percentage of PMN cells, concentration of albumin, thromboxane B2 and IL-8 in BALF." | 1.32 | Effects of propofol on endotoxin-induced acute lung injury in rabbit. ( Choi, JI; Kwak, SH; Park, JT, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Li, T | 1 |
| Zeng, QS | 1 |
| She, SZ | 1 |
| O'Gara, BP | 1 |
| Shaefi, S | 1 |
| Gasangwa, DV | 1 |
| Patxot, M | 1 |
| Beydoun, N | 1 |
| Mueller, AL | 1 |
| Sagy, I | 1 |
| Novack, V | 1 |
| Banner-Goodspeed, VM | 1 |
| Kumaresan, A | 1 |
| Shapeton, A | 1 |
| Spear, K | 1 |
| Bose, S | 1 |
| Baedorf Kassis, EN | 1 |
| Gosling, AF | 1 |
| Mahmood, FU | 1 |
| Khabbaz, K | 1 |
| Subramaniam, B | 1 |
| Talmor, DS | 1 |
| Gerber, D | 1 |
| Vasireddy, R | 1 |
| Varadarajan, B | 1 |
| Hartwich, V | 1 |
| Schär, MY | 1 |
| Eberle, B | 1 |
| Vogt, A | 1 |
| Li, Q | 1 |
| Cui, S | 1 |
| Jing, G | 1 |
| Ding, H | 1 |
| Xia, Z | 1 |
| He, X | 1 |
| Eikermann, M | 1 |
| Vidal Melo, MF | 1 |
| Yang, P | 1 |
| Yang, N | 1 |
| Zhang, X | 1 |
| Xu, X | 1 |
| O'Gara, B | 1 |
| Talmor, D | 1 |
| Bae, HB | 1 |
| Li, M | 1 |
| Lee, SH | 1 |
| Jeong, CW | 1 |
| Kim, SJ | 1 |
| Kim, HS | 1 |
| Chung, SS | 1 |
| Kwak, SH | 2 |
| Hung, CJ | 1 |
| Liu, FY | 1 |
| Shaiu, YC | 1 |
| Kao, A | 1 |
| Lin, CC | 1 |
| Lee, CC | 1 |
| Choi, JI | 1 |
| Park, JT | 1 |
| Hu, XM | 1 |
| Lu, Y | 1 |
| Yao, SL | 1 |
| Fitzsimons, MG | 1 |
| Baker, KH | 1 |
| Peralta, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| AnaConDa-therapy in COVID-19 Patients[NCT05586126] | 42 participants (Actual) | Observational | 2020-10-01 | Terminated (stopped due to Concerns about possible association between drug and increased ICU mortality) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for propofol and Chronic Lung Injury
| Article | Year |
|---|---|
Lung protective properties of the volatile anesthetics.
Topics: Anesthetics, Inhalation; Animals; Desflurane; Humans; Intensive Care Units; Isoflurane; Lung Injury; | 2016 |
2 trials available for propofol and Chronic Lung Injury
| Article | Year |
|---|---|
Limb Remote Ischemic Preconditioning Applied During Sevoflurane Anesthesia Does Not Protect the Lungs in Patients Undergoing Adult Heart Valve Surgery.
Topics: Adult; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Aorta; Bronchoalveolar Lavage; Const | 2021 |
Anesthetics to Prevent Lung Injury in Cardiac Surgery: A Randomized Controlled Trial.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarkers; Cardiac Surgical Procedures; H | 2022 |
9 other studies available for propofol and Chronic Lung Injury
| Article | Year |
|---|---|
Near-real-time pulmonary shunt and dead space measurement with micropore membrane inlet mass spectrometry in pigs with induced pulmonary embolism or acute lung failure.
Topics: Anesthesia, General; Animals; Blood Gas Analysis; Chromatography, Gas; Gases; Hemodynamics; Lung; Lu | 2019 |
The role of PI3K/Akt signal pathway in the protective effects of propofol on intestinal and lung injury induced by intestinal ischemia/reperfusion1.
Topics: Anesthetics, Intravenous; Animals; Disease Models, Animal; Lung Injury; Male; Mesenteric Ischemia; P | 2019 |
Therapeutic range of spontaneous breathing during mechanical ventilation.
Topics: Anesthetics, Intravenous; Animals; Diaphragm; Lung Injury; Male; Muscular Atrophy; Propofol; Respira | 2014 |
The significance and mechanism of propofol on treatment of ischemia reperfusion induced lung injury in rats.
Topics: Animals; Cytokines; Female; Lung; Lung Injury; Male; Propofol; Rats; Rats, Sprague-Dawley; Reperfusi | 2014 |
Propofol attenuates pulmonary injury induced by collapse and reventilation of lung in rabbits.
Topics: Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Inflammati | 2013 |
Assessing transient pulmonary injury induced by volatile anesthetics by increased lung uptake of technetium-99m hexamethylpropylene amine oxime.
Topics: Adult; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Endothelium, Vascular; Female; Fenta | 2003 |
Effects of propofol on endotoxin-induced acute lung injury in rabbit.
Topics: Acute Disease; Albumins; Anesthetics, Intravenous; Animals; Blood Platelets; Blood Pressure; Broncho | 2004 |
[Propofol reduces intercellular adhesion molecular-1 expression in lung injury following intestinal ischemia/reperfusion in rats].
Topics: Animals; Disease Models, Animal; Female; Intercellular Adhesion Molecule-1; Intestines; Lung Injury; | 2005 |
Anesthetic implications of traumatic pulmonary hernia repair.
Topics: Accidents, Traffic; Anesthesia; Anesthetics, Intravenous; Atracurium; Hernia; Herniorrhaphy; Humans; | 2005 |