propofol has been researched along with Cholera Infantum in 19 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the efficacy and security of different administrations of propofol on the sedation in upper gastrointestinal endoscopic procedures in snoring patients." | 5.14 | [Efficacy and security of sedation in upper gastrointestinal endoscopy in snoring patients]. ( Shen, S; Tang, W; Wang, F; Wang, X; Xiao, D; Yang, H, 2010) |
| " Safety and tolerability were assessed by adverse events, neurologic examinations, clinical laboratory tests, and vital signs." | 2.78 | A randomized open-label phase I pilot study of the safety and efficacy of total intravenous anesthesia with fospropofol for coronary artery bypass graft surgery. ( Fechner, J; Ihmsen, H; Jeleazcov, C; Schüttler, J, 2013) |
| "Propofol has been suggested to be superior to benzodiazepines when used as a sedative agent for endoscopic examination." | 2.50 | Propofol versus traditional sedative agents for endoscopic submucosal dissection. ( Kanai, T; Matsuzaki, J; Nishizawa, T; Suzuki, H; Yahagi, N, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (36.84) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| He, Z | 1 |
| Zhang, H | 1 |
| Xing, Y | 1 |
| Liu, J | 1 |
| Gao, Y | 1 |
| Gu, E | 1 |
| Zhang, L | 1 |
| Chen, L | 1 |
| Tarway, NK | 1 |
| Jain, M | 1 |
| Rajavel, VP | 1 |
| Melpakkam, S | 1 |
| Srinivasan, V | 1 |
| Ravi, R | 1 |
| Varghese, J | 1 |
| Michael, T | 1 |
| Venkataraman, J | 1 |
| Frieling, T | 1 |
| Heise, J | 1 |
| Kreysel, C | 1 |
| Kuhlen, R | 1 |
| Schepke, M | 1 |
| Fechner, J | 1 |
| Ihmsen, H | 1 |
| Schüttler, J | 1 |
| Jeleazcov, C | 1 |
| Nishizawa, T | 1 |
| Suzuki, H | 1 |
| Matsuzaki, J | 1 |
| Kanai, T | 1 |
| Yahagi, N | 1 |
| Voynarovska, M | 1 |
| Cohen, LB | 1 |
| Feld, AD | 1 |
| Pambianco, DJ | 3 |
| Devlin, JW | 1 |
| Mallow-Corbett, S | 1 |
| Riker, RR | 1 |
| Xiao, D | 1 |
| Wang, F | 1 |
| Wang, X | 1 |
| Tang, W | 1 |
| Yang, H | 1 |
| Shen, S | 1 |
| Vargo, JJ | 1 |
| Pruitt, RE | 1 |
| Hardi, R | 2 |
| Martin, JF | 2 |
| Coté, GA | 1 |
| Bridenbaugh, P | 1 |
| Gustafson, M | 1 |
| Heuss, LT | 1 |
| Hanhart, A | 1 |
| Dell-Kuster, S | 1 |
| Zdrnja, K | 1 |
| Ortmann, M | 1 |
| Beglinger, C | 1 |
| Bucher, HC | 1 |
| Degen, L | 1 |
| Lee, DW | 1 |
| Chan, AC | 1 |
| Sze, TS | 1 |
| Ko, CW | 1 |
| Poon, CM | 1 |
| Chan, KC | 1 |
| Sin, KS | 1 |
| Chung, SC | 1 |
| Baudet, JS | 1 |
| del Río, AS | 1 |
| Alarcón-Fernandez, O | 1 |
| Pecoraro, AP | 1 |
| Cacchione, RN | 1 |
| Sayad, P | 1 |
| Williams, ME | 1 |
| Ferzli, GS | 1 |
| Leslie, K | 1 |
| Troedel, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of High-flow Nasal Oxygenation vs. Low-flow Nasal Oxygenation on Oxygen Saturation During Analgo-sedation in Obese Adult Patients, Randomized Controlled Trial[NCT03687424] | 126 participants (Anticipated) | Interventional | 2018-10-30 | Not yet recruiting | |||
| Effect of High-flow vs. Low-flow Nasal Oxygenation on Spontaneous Ventilation in Obese Adult Patients During Analgo-sedation for Vitrectomy, Randomized Controlled Trial[NCT04049240] | 126 participants (Anticipated) | Interventional | 2019-08-01 | Recruiting | |||
| Ketamine and Propofol Combination Versus Propofol for Upper Gastrointestinal Endoscopy[NCT02643979] | Phase 4 | 22 participants (Actual) | Interventional | 2016-01-01 | Terminated (stopped due to Lack of Enrollment) | ||
| Multi-center Pivotal Clinical Trial to Compare the Safety and Effectiveness of Procedural Sedation in GI Endoscopy: A Computer-Assisted Personalized Sedation (CAPS) Device Versus Current Standard of Care[NCT00452426] | Phase 3 | 1,000 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| Effect of Palatable Lidocaine Gel Versus Dexmedetomidine on Gag Reflex During Propofol Based Sedation for Patients Undergoing Elective Upper Gastrointestinal Endoscopy. A Randomized Controlled Study[NCT04213833] | 120 participants (Actual) | Interventional | 2020-01-01 | Completed | |||
| Study of Propofol Sedation During Upper Endoscopy With and Without Topical Pharyngeal Anesthesia[NCT01081002] | Phase 4 | 294 participants (Actual) | Interventional | 2009-08-31 | Completed | ||
| The Application of Topical Pharyngeal Anesthesia in the Esophagogastroduodenoscopy Under Sedation[NCT03070379] | 300 participants (Anticipated) | Interventional | 2017-02-20 | Recruiting | |||
| [NCT00848861] | 92 participants (Actual) | Interventional | 2006-02-28 | Completed | |||
| Comparison of Ketamine-propofol Sedation Protocols With Fentanyl-propofol Administered by Endoscopist or Anesthesiologist at Colonoscopy[NCT03607110] | 120 participants (Actual) | Observational | 2018-03-01 | Completed | |||
| Anesthesiological Strategies in Elective Craniotomy: Randomized, Equivalence, Open Trial[NCT00741351] | Phase 3 | 411 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| A Comparison Between Scalp Nerve Block and Scalp Infiltration on the Circulatory and Stress Response for Aneurysm Clipping Using an Enhanced Recovery After Surgery Programme[NCT03073889] | 45 participants (Anticipated) | Interventional | 2016-06-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Anesthesiologist caring for the patient during the upper endoscopy made note of any obstructive events defined on a scale ranging from the patient audibly snoring (obstructing) to the patient obstructing and requiring assistance such as a chin lift or jaw thrust to relieve the obstruction and continue to move air adequately. (NCT02643979)
Timeframe: Day 1
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketofol: Ketamine and Propofol | 4 |
| Propofol Only | 3 |
Number of participants with emergence delirium measured from the procedure end until time of discharge. (NCT02643979)
Timeframe: Day 1
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketofol: Ketamine and Propofol | 0 |
| Propofol Only | 0 |
"Number of participants with gagging or vomit-like reaction on endoscopic insertion" (NCT02643979)
Timeframe: Day 1
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketofol: Ketamine and Propofol | 2 |
| Propofol Only | 1 |
(NCT02643979)
Timeframe: up to 6 months
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketofol: Ketamine and Propofol | 0 |
| Propofol Only | 0 |
Monitored via the electronic medical record system as the time between the anesthesia end time and when the patient was safe for discharge from the hospital. (NCT02643979)
Timeframe: Day 1
| Intervention | minutes (Mean) |
|---|---|
| Ketofol: Ketamine and Propofol | 21 |
| Propofol Only | 25 |
Propofol doses are logged in the computerized Compurecord system used in the operating room. Patients involved in the study had their total Propofol dose required quantified and compared between groups who received Ketamine and groups who did not. (NCT02643979)
Timeframe: Day 1
| Intervention | mg/kg (Mean) |
|---|---|
| Ketofol: Ketamine and Propofol | 9.09 |
| Propofol Only | 39 |
Using the computerized record system, the amount of Propofol a patient required to allow for the procedure to start quantified and compared between groups. (NCT02643979)
Timeframe: Day 1
| Intervention | mg/kg (Mean) |
|---|---|
| Ketofol: Ketamine and Propofol | 78 |
| Propofol Only | 61 |
AUCDesat measures desaturation as a function of incidence, magnitude, and duration. AUCDesat is the difference between the threshold and actual oxygen saturation measured every second. The total area below the 90% threshold is summated to determine AUCDesat in units of seconds*percent. (NCT00452426)
Timeframe: From administration of initial drug dose until subject recovered from effects of sedation
| Intervention | seconds*percent of oxygen desaturation (Mean) |
|---|---|
| Sedation System | 23.6 |
| Current Standard of Care | 88.0 |
Clinician Satisfaction with Sedation Instrument (CSSI) is a scale measuring the clinician satisfactin with the sedation they delivered. This validated scale consists of 16 questions that are scored and converted to a 0-100 scale, where 100 represented the most satisfied. (NCT00452426)
Timeframe: Post procedure
| Intervention | Scores on a scale (Mean) |
|---|---|
| Sedation System | 92.2 |
| Current Standard of Care | 76.3 |
Duration of Modified Observers Assessment of Alertness and Sedation (MOAA/S)score of 0 or 1 MOAA/S is a scale of numbers ranging from 0-5, 5 being defined as being awake or minimally sedatied, and 0 defined as being at the deepest level of sedation (general anethesia). The mean MOAA/S score was the sum of each subject's scores during the procedure divided by the number of non-missing scores. (NCT00452426)
Timeframe: From first dose until subject recovered from effects of sedation
| Intervention | minutes (Mean) |
|---|---|
| Sedation System | 0.1 |
| Current Standard of Care | 0.1 |
Patient Satisfaction with Sedation Instrument (PSSI) is a scale measuring patient satisfactin with the sedation they received. This validated scale consists of 16 questions that are scored and converted to a 0-100 scale, where 100 represented the most satisfied. (NCT00452426)
Timeframe: 24-48 hours post sedation
| Intervention | Scores on a scale (Mean) |
|---|---|
| Sedation System | 92.3 |
| Current Standard of Care | 89.7 |
Recovery time- time for patient to reach first of two consecutive MOAA/S of 5 from the time scope was removed. (NCT00452426)
Timeframe: "from scope out until first of two consecutive MOAA/S scores of 5"
| Intervention | minutes (Mean) |
|---|---|
| Sedation System | 2.9 |
| Current Standard of Care | 6.5 |
6 reviews available for propofol and Cholera Infantum
| Article | Year |
|---|---|
Propofol versus traditional sedative agents for endoscopic submucosal dissection.
Topics: Dissection; Endoscopy; Gastrointestinal Diseases; Humans; Hypnotics and Sedatives; Propofol; Randomi | 2014 |
The role of the endoscopy nurse or assistant in endoscopic sedation.
Topics: Anesthetics, Intravenous; Conscious Sedation; Endoscopy, Gastrointestinal; Gastrointestinal Diseases | 2008 |
Endoscopic sedation: medicolegal considerations.
Topics: Conscious Sedation; Endoscopy, Gastrointestinal; Gastrointestinal Diseases; Humans; Informed Consent | 2008 |
Future directions in endoscopic sedation.
Topics: Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Anesthetics, Dissociative; Conscious Sedati | 2008 |
Adverse drug events associated with the use of analgesics, sedatives, and antipsychotics in the intensive care unit.
Topics: Acidosis; Analgesics; Antipsychotic Agents; Bradycardia; Cardiovascular Diseases; Critical Care; Dru | 2010 |
Does anaesthesia care affect the outcome following craniotomy?
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Craniotomy; Gastrointestinal Diseases; Humans; Pain, | 2002 |
Does anaesthesia care affect the outcome following craniotomy?
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Craniotomy; Gastrointestinal Diseases; Humans; Pain, | 2002 |
Does anaesthesia care affect the outcome following craniotomy?
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Craniotomy; Gastrointestinal Diseases; Humans; Pain, | 2002 |
Does anaesthesia care affect the outcome following craniotomy?
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Craniotomy; Gastrointestinal Diseases; Humans; Pain, | 2002 |
7 trials available for propofol and Cholera Infantum
| Article | Year |
|---|---|
Effect of raw electroencephalogram-guided anesthesia administration on postoperative outcomes in elderly patients undergoing abdominal major surgery: a randomized controlled trial.
Topics: Aged; Anesthesia; Anesthesia, General; Anesthetics; Electroencephalography; Gastrointestinal Disease | 2023 |
Sedation-associated complications in endoscopy--prospective multicentre survey of 191142 patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Drug-Related Side Effects and A | 2013 |
Sedation-associated complications in endoscopy--prospective multicentre survey of 191142 patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Drug-Related Side Effects and A | 2013 |
Sedation-associated complications in endoscopy--prospective multicentre survey of 191142 patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Drug-Related Side Effects and A | 2013 |
Sedation-associated complications in endoscopy--prospective multicentre survey of 191142 patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Drug-Related Side Effects and A | 2013 |
A randomized open-label phase I pilot study of the safety and efficacy of total intravenous anesthesia with fospropofol for coronary artery bypass graft surgery.
Topics: Aged; Anesthesia, Intravenous; Cardiovascular Diseases; Coronary Artery Bypass; Female; Follow-Up St | 2013 |
[Efficacy and security of sedation in upper gastrointestinal endoscopy in snoring patients].
Topics: Adult; Endoscopy, Gastrointestinal; Female; Gastrointestinal Diseases; Humans; Hypnotics and Sedativ | 2010 |
Computer-assisted personalized sedation for upper endoscopy and colonoscopy: a comparative, multicenter randomized study.
Topics: Adult; Aged; Anesthetics, Intravenous; Colonoscopy; Conscious Sedation; Dose-Response Relationship, | 2011 |
Propofol sedation alone or in combination with pharyngeal lidocaine anesthesia for routine upper GI endoscopy: a randomized, double-blind, placebo-controlled, non-inferiority trial.
Topics: Administration, Topical; Anesthesia, Local; Anesthetics, Intravenous; Anesthetics, Local; Conscious | 2011 |
Propofol sedation alone or in combination with pharyngeal lidocaine anesthesia for routine upper GI endoscopy: a randomized, double-blind, placebo-controlled, non-inferiority trial.
Topics: Administration, Topical; Anesthesia, Local; Anesthetics, Intravenous; Anesthetics, Local; Conscious | 2011 |
Propofol sedation alone or in combination with pharyngeal lidocaine anesthesia for routine upper GI endoscopy: a randomized, double-blind, placebo-controlled, non-inferiority trial.
Topics: Administration, Topical; Anesthesia, Local; Anesthetics, Intravenous; Anesthetics, Local; Conscious | 2011 |
Propofol sedation alone or in combination with pharyngeal lidocaine anesthesia for routine upper GI endoscopy: a randomized, double-blind, placebo-controlled, non-inferiority trial.
Topics: Administration, Topical; Anesthesia, Local; Anesthetics, Intravenous; Anesthetics, Local; Conscious | 2011 |
Propofol sedation alone or in combination with pharyngeal lidocaine anesthesia for routine upper GI endoscopy: a randomized, double-blind, placebo-controlled, non-inferiority trial.
Topics: Administration, Topical; Anesthesia, Local; Anesthetics, Intravenous; Anesthetics, Local; Conscious | 2011 |
Propofol sedation alone or in combination with pharyngeal lidocaine anesthesia for routine upper GI endoscopy: a randomized, double-blind, placebo-controlled, non-inferiority trial.
Topics: Administration, Topical; Anesthesia, Local; Anesthetics, Intravenous; Anesthetics, Local; Conscious | 2011 |
Propofol sedation alone or in combination with pharyngeal lidocaine anesthesia for routine upper GI endoscopy: a randomized, double-blind, placebo-controlled, non-inferiority trial.
Topics: Administration, Topical; Anesthesia, Local; Anesthetics, Intravenous; Anesthetics, Local; Conscious | 2011 |
Propofol sedation alone or in combination with pharyngeal lidocaine anesthesia for routine upper GI endoscopy: a randomized, double-blind, placebo-controlled, non-inferiority trial.
Topics: Administration, Topical; Anesthesia, Local; Anesthetics, Intravenous; Anesthetics, Local; Conscious | 2011 |
Propofol sedation alone or in combination with pharyngeal lidocaine anesthesia for routine upper GI endoscopy: a randomized, double-blind, placebo-controlled, non-inferiority trial.
Topics: Administration, Topical; Anesthesia, Local; Anesthetics, Intravenous; Anesthetics, Local; Conscious | 2011 |
Patient-controlled sedation versus intravenous sedation for colonoscopy in elderly patients: a prospective randomized controlled trial.
Topics: Aged; Alfentanil; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Colonoscopy; Conscious Se | 2002 |
Patient-controlled sedation versus intravenous sedation for colonoscopy in elderly patients: a prospective randomized controlled trial.
Topics: Aged; Alfentanil; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Colonoscopy; Conscious Se | 2002 |
Patient-controlled sedation versus intravenous sedation for colonoscopy in elderly patients: a prospective randomized controlled trial.
Topics: Aged; Alfentanil; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Colonoscopy; Conscious Se | 2002 |
Patient-controlled sedation versus intravenous sedation for colonoscopy in elderly patients: a prospective randomized controlled trial.
Topics: Aged; Alfentanil; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Colonoscopy; Conscious Se | 2002 |
6 other studies available for propofol and Cholera Infantum
| Article | Year |
|---|---|
Patient satisfaction and safety profile with sedation during gastrointestinal endoscopy.
Topics: Conscious Sedation; Endoscopy, Gastrointestinal; Fentanyl; Gastrointestinal Diseases; Humans; Infusi | 2017 |
The debate for nonanesthesiologist-administered propofol sedation in endoscopy rages on: who will be the "King of Prop?".
Topics: Anesthetics, Intravenous; Colonoscopy; Conscious Sedation; Dose-Response Relationship, Drug; Drug Th | 2011 |
The debate for nonanesthesiologist-administered propofol sedation in endoscopy rages on.
Topics: Anesthetics, Intravenous; Conscious Sedation; Drug Therapy, Computer-Assisted; Endoscopy, Gastrointe | 2011 |
The SEDASYS System is not intended for the sedation of high-risk patients.
Topics: Anesthetics, Intravenous; Conscious Sedation; Drug Therapy, Computer-Assisted; Endoscopy, Gastrointe | 2011 |
The effect of sedation on the quality of upper gastrointestinal endoscopy. Letter to Dr. Meining et al.: Sedation and the quality of upper gastrointestinal endoscopy.
Topics: Conscious Sedation; Endoscopy, Gastrointestinal; Female; Gastrointestinal Diseases; Humans; Male; Mi | 2008 |
The routine use of diagnostic laparoscopy in the intensive care unit.
Topics: Abdomen; Abdomen, Acute; Adult; Aged; Anesthesia, Local; Female; Gastrointestinal Diseases; Humans; | 2001 |