propofol has been researched along with Cerebral Ischemia in 83 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acute ischemic stroke is associated with pulmonary complications, and often dexmedetomidine and propofol are used to decrease cerebral metabolic rate." | 8.02 | Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke. ( Antunes, MA; Battaglini, D; Cruz, FF; da Silva, CM; Fernandes, MV; Pelosi, P; Robba, C; Rocco, PRM; Samary, CS; Silva, PL; Sousa, GC; Takyia, C, 2021) |
| " Propofol (2,6-diisopropylphenol) has been proven to attenuate mitochondrial dysfunction and reperfusion injury." | 7.88 | Propofol Prevents Oxidative Stress by Decreasing the Ischemic Accumulation of Succinate in Focal Cerebral Ischemia-Reperfusion Injury. ( Gao, D; Jin, W; Liu, S; Qi, S; Yu, W, 2018) |
| " The study aimed to estimate the efficacy of estrogen and propofol combination therapy against ERS-induced apoptosis after cerebral ischemia-reperfusion injury and oxygen-glucose deprivation (OGD) injury in the hippocampus in vivo and in vitro." | 7.88 | Estrogen and propofol combination therapy inhibits endoplasmic reticulum stress and remarkably attenuates cerebral ischemia-reperfusion injury and OGD injury in hippocampus. ( Li, Y; Ma, R; Wang, E; Wang, S; Xiong, E; Xu, F; Yin, J; Zhang, G; Zhang, Q, 2018) |
| "Neuroprotective effect of propofol against cerebral ischemia injury was widely investigated." | 7.83 | Propofol Prevents Hippocampal Neuronal Loss and Memory Impairment in Cerebral Ischemia Injury Through Promoting PTEN Degradation. ( Chen, X; Du, YM; Liu, D; Wang, YL; Xu, F, 2016) |
| "To investigate the protective effect of propofol against focal cerebral ischemia/reperfusion (I/R) injury in rats and its relation with gap junction." | 7.81 | [Protective effect of propofol against cerebral ischemic/reperfusion injury may involve inhibition of gap junction]. ( Chen, Y; Dong, S; Fan, Z; Li, Y; Liu, H; Tong, X; Yu, L, 2015) |
| "There is limited data on the safety, hemodynamic profile, and outcome of patients undergoing intra-arterial therapy (IAT) for acute ischemic stroke (AIS) under sedation with dexmedetomidine (DEX) versus propofol (PROP)." | 7.81 | Safety and Hemodynamic Profile of Propofol and Dexmedetomidine Anesthesia during Intra-arterial Acute Stroke Therapy. ( Dupler, S; Farag, E; Gomes, J; Hussain, MS; John, S; Somal, J; Thebo, U, 2015) |
| "Propofol, an intravenous anesthetic, inhibits neuronal apoptosis induced by ischemic stroke, protects the brain from ischemia/reperfusion injury and improves neuronal function." | 7.81 | Propofol post-conditioning protects the blood brain barrier by decreasing matrix metalloproteinase-9 and aquaporin-4 expression and improves the neurobehavioral outcome in a rat model of focal cerebral ischemia-reperfusion injury. ( Cao, MH; Ji, FT; Liang, JJ; Miao, LP; Wu, Q, 2015) |
| "It has been shown in our previous study that propofol postconditioning enhanced the activity of phosphatidylinositol-3-kinase (PI3K) and prevented the internalization of GluR2 subunit of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thus provided neuroprotection in cerebral ischemia/reperfusion (I/R) injury." | 7.81 | The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats. ( Liu, S; Wang, G; Wang, H; Zhu, A, 2015) |
| "Propofol is a commonly used intravenous anesthetic that has been demonstrated to be neuroprotective against cerebral ischemia-reperfusion (I/R) injury." | 7.81 | Propofol prevents neuronal mtDNA deletion and cerebral damage due to ischemia/reperfusion injury in rats. ( Chang, FF; Dong, H; Liu, Y; Lu, SJ; Qian, H; Song, CY; Wang, YF; Yang, WC; Yue, ZY, 2015) |
| "The neuroprotective effects of propofol postconditioning in brain ischemia/reperfusion injury may be partially through the induction of the HO-1 expression." | 7.79 | Propofol attenuates cerebral ischemia/reperfusion injury partially using heme oxygenase-1. ( Cang, J; Liang, C; Wang, H; Xue, Z, 2013) |
| "Several mechanisms are involved in the neuroprotection of propofol against ischemia, but influences of propofol on the binding properties of glutamate receptors and the uptake of glutamate in brain ischemia are not known." | 7.77 | The neuroprotective effect of propofol against brain ischemia mediated by the glutamatergic signaling pathway in rats. ( Cai, J; Hu, Y; Li, L; Li, Q; Li, S; Li, W; Zhang, M, 2011) |
| "Propofol is an intravenous anesthetic with neuroprotective effects against cerebral ischemia-reperfusion (I/R) injury." | 7.77 | Propofol improved neurobehavioral outcome of cerebral ischemia-reperfusion rats by regulating Bcl-2 and Bax expression. ( Cui, XG; Lu, SJ; Song, CY; Tao, T; Xi, HJ; Yue, ZY; Zhang, TH, 2011) |
| "Eighty male Sprague-Dawley rats were randomly assigned to treatment groups with propofol administration for 3 h: 36 mg x kg(-1) x h(-1) propofol with or without cerebral ischemia and 72 mg x kg(-1) x h(-1) propofol with or without cerebral ischemia." | 7.75 | Assessment of postischemic neurogenesis in rats with cerebral ischemia and propofol anesthesia. ( Engelhard, K; Lasarzik, I; Orth, C; Schneider, A; Stallmann, S; Tresch, A; Werner, C; Winkelheide, U, 2009) |
| " This study was designed to quantitatively evaluate the neuroprotective effects of thiopental, propofol, and halothane on brain ischemia by determining P50, ischemic time necessary for causing 50% neuronal damage." | 7.74 | Quantitative evaluation of the neuroprotective effects of thiopental sodium, propofol, and halothane on brain ischemia in the gerbil: effects of the anesthetics on ischemic depolarization and extracellular glutamate concentration. ( Aoe, H; Kobayashi, M; Morita, K; Takata, K; Takeda, Y; Taninishi, H, 2007) |
| "Propofol (2,6-diisopropylphenol) has been shown to attenuate neuronal injury in a number of experimental conditions, but studies in models of cerebral ischemia have yielded conflicting results." | 7.73 | Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism. ( Adembri, C; Chiarugi, A; Cozzi, A; De Gaudio, RA; Gramigni, E; Pancani, T; Pellegrini-Giampietro, DE; Tani, A; Venturi, L, 2006) |
| "Propofol and midazolam, but not thiopental sodium, may provide protective effects against reperfusion induced injury in rats subjected to focal cerebral ischemia." | 7.72 | Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats. ( Chen, L; Gong, Q; Xiao, C, 2003) |
| "To compare the effects of ketamine, midazolam, thiopental, and propofol on brain ischemia by the model of oxygen-glucose deprivation (OGD) in rat cerebral cortical slices." | 7.72 | Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices. ( Chen, HZ; Wang, ZJ; Xue, QS; Yu, BW, 2004) |
| "During incomplete cerebral ischemia, the neuroprotective anesthetics sevoflurane and propofol suppressed cerebral increases in norepinephrine and glutamate concentrations." | 7.72 | The effect of sevoflurane and propofol on cerebral neurotransmitter concentrations during cerebral ischemia in rats. ( Blobner, M; Engelhard, K; Hoffman, WE; Kochs, E; Matthes, B; Werner, C, 2003) |
| "To compare the effects of pentobarbital and propofol on the outcome of focal cerebral ischemia model, and to evaluate the availability of propofol in setting the focal cerebral ischemia." | 7.72 | [Comparison of pentobarbital and propofol on the outcome of focal cerebral ischemia model in rats]. ( Kang, QY; Li, J; Liu, Y; Zhang, PB; Zhao, JJ, 2004) |
| "Propofol reduces neuronal damage from cerebral ischemia when investigated for less than 8 postischemic days." | 7.72 | Influence of propofol on neuronal damage and apoptotic factors after incomplete cerebral ischemia and reperfusion in rats: a long-term observation. ( Eberspächer, E; Engelhard, K; Hollweck, R; Hutzler, P; Kellermann, K; Kochs, E; Pape, M; Stegemann, U; Werner, C, 2004) |
| " We measured the levels of malondialdehyde as a marker of lipid peroxidation in ischemic tissue, and the results indicate that propofol plays a role in the inhibition of neuronal death induced by brain ischemia." | 7.71 | Neuroprotective effects of propofol following global cerebral ischemia in rats. ( Akdemir, G; Ergün, R; Ergüngör, F; Sen, S; Taşçi, A, 2002) |
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 7.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "It has been suggested that propofol has the protective effect on cerebral ischemia-reperfusion injury." | 7.70 | Effectiveness of propofol pretreatment on the extent of deranged cerebral mitochondrial oxidative enzyme system after incomplete forebrain ischemia/reperfusion in rats. ( Chung, C; Lee, Y; Oh, YS, 2000) |
| "The increment of GABAergic inhibitory activity, the reduction of metabolic rate and oxygen consumption induced by propofol on the neuronal components of brain structures, and its antioxidant potential have supported the possible beneficial effects of this drug against brain damage elicited by cerebral ischemia." | 7.69 | Effects of propofol on alterations of multineuronal activity of limbic and mesencephalic structures and neurological deficit elicited by acute global cerebral ischemia. ( Antonio-Ocampo, A; Cervantes, M; Chávez-Carrillo, I; Contreras-Gomez, A; Ruelas, R, 1995) |
| "This study was designed to test the hypothesis that propofol, which possesses antioxidant properties, would produce greater protection than isoflurane in cerebral ischaemia reperfusion injury, at dose levels that produced similar affects on brain electrical activity." | 7.69 | Propofol neuroprotection in a rat model of ischaemia reperfusion injury. ( Jones, JG; Matta, BF; Menon, DK; Tisavipat, N; Young, Y, 1997) |
| "Propofol is an intravenous anesthetic that is commonly used during intravascular embolectomy following acute ischemic stroke." | 5.56 | Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke. ( Cui, V; Tian, D; Wang, H; Wang, Y; Wei, C; Wu, A; Yue, Y; Zhu, Y, 2020) |
| "Pretreatment with propofol attenuates autogenous orthotropic liver transplantation induces hippocampal injury via JAK2/STAT3 pathway." | 5.46 | Propofol postconditioning attenuates hippocampus ischemia-reperfusion injury via modulating JAK2/STAT3 pathway in rats after autogenous orthotropic liver transplantation. ( Du, H; Gu, X; Jia, L; Li, S; Sheng, M; Wang, F; Wang, G; Weng, Y; Yu, W, 2017) |
| "Propofol has been shown to attenuate brain injury in experimental ischemia models, but few studies have focused on the direct effect of propofol on mitochondrial dysfunction." | 5.40 | The effects of propofol on mitochondrial dysfunction following focal cerebral ischemia-reperfusion in rats. ( Li, B; Li, J; Li, XT; Qi, SH; Yu, W, 2014) |
| "Propofol has been shown to attenuate ischemic brain damage via inhibiting neuronal apoptosis." | 5.40 | Propofol reduces inflammatory reaction and ischemic brain damage in cerebral ischemia in rats. ( Chen, JP; Chen, Y; Shi, SS; Tu, XK; Yang, WZ, 2014) |
| "Propofol treatment reduced infarct volume and improved the neurological functions." | 5.39 | Propofol protects against focal cerebral ischemia via inhibition of microglia-mediated proinflammatory cytokines in a rat model of experimental stroke. ( Liu, F; Tan, Y; Tang, X; Wu, X; Yang, Z; Zhou, R, 2013) |
| "A transient global cerebral ischemia-reperfusion (I/R) model was produced with a 10-min, 2-vessel occlusion." | 5.39 | Propofol prevents cerebral ischemia-triggered autophagy activation and cell death in the rat hippocampus through the NF-κB/p53 signaling pathway. ( Cui, DR; Jiang, W; Qi, AH; Wang, L; Zhang, XL; Zhou, QH, 2013) |
| "Propofol has been demonstrated to ameliorate cerebral ischemic injury and attenuate changes in multiple links of molecular reaction included in the paths to apoptosis." | 5.35 | Effect of propofol on pathologic time-course and apoptosis after cerebral ischemia-reperfusion injury. ( Chen, L; Jiang, H; Xue, Z, 2008) |
| "Cerebral ischemia was induced in awake Wistar rats by a local intracerebral injection of the potent vasoconstrictor, endothelin (6 pmol in 3 microl) into the striatum." | 5.32 | Propofol neuroprotection in cerebral ischemia and its effects on low-molecular-weight antioxidants and skilled motor tasks. ( Bayona, NA; Cechetto, DF; Gelb, AW; Jiang, Z; Urquhart, BL; Wilson, JX, 2004) |
| "Favorable outcome rates were similar in stroke patients receiving propofol or volatile GA during ET." | 4.84 | The Effect of Anesthetic Agent and Mean Arterial Pressure on Functional Outcome After General Anesthesia for Endovascular Thrombectomy. ( Ayotte, S; Crimmins, D; Highton, D; Lwin, TN; Redmond, K; Ryan, E; Shah, D, 2024) |
| "Acute ischemic stroke is associated with pulmonary complications, and often dexmedetomidine and propofol are used to decrease cerebral metabolic rate." | 4.02 | Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke. ( Antunes, MA; Battaglini, D; Cruz, FF; da Silva, CM; Fernandes, MV; Pelosi, P; Robba, C; Rocco, PRM; Samary, CS; Silva, PL; Sousa, GC; Takyia, C, 2021) |
| "Rats underwent 1 h of focal cerebral ischemia followed by 23 h of reperfusion were randomly divided into 6 groups (n = 36 per group): sham- operation (S), ischemia-reperfusion (IR), propofol (P group, propofol 20 mg/kg/h at the onset of reperfusion for 2 h after 60 min of occlusion), and LY294002 (PI3K non-selective antagonist) + sham (L + S, LY294002 of 1." | 3.91 | The role of PI3K-mediated AMPA receptor changes in post-conditioning of propofol in brain protection. ( Dong, B; Shi, Y; Wang, C; Wang, G; Wei, Y; Xie, K; Yu, Y; Yuan, Y, 2019) |
| " Propofol (2,6-diisopropylphenol) has been proven to attenuate mitochondrial dysfunction and reperfusion injury." | 3.88 | Propofol Prevents Oxidative Stress by Decreasing the Ischemic Accumulation of Succinate in Focal Cerebral Ischemia-Reperfusion Injury. ( Gao, D; Jin, W; Liu, S; Qi, S; Yu, W, 2018) |
| " The study aimed to estimate the efficacy of estrogen and propofol combination therapy against ERS-induced apoptosis after cerebral ischemia-reperfusion injury and oxygen-glucose deprivation (OGD) injury in the hippocampus in vivo and in vitro." | 3.88 | Estrogen and propofol combination therapy inhibits endoplasmic reticulum stress and remarkably attenuates cerebral ischemia-reperfusion injury and OGD injury in hippocampus. ( Li, Y; Ma, R; Wang, E; Wang, S; Xiong, E; Xu, F; Yin, J; Zhang, G; Zhang, Q, 2018) |
| "Global brain ischemia-reperfusion during propofol anesthesia provokes persistent cerebral pial constriction." | 3.85 | The effects of Y-27632 on pial microvessels during global brain ischemia and reperfusion in rabbits. ( Asano, N; Ishiyama, T; Kotoda, M; Matsukawa, T; Sessler, DI; Shintani, N, 2017) |
| "Neuroprotective effect of propofol against cerebral ischemia injury was widely investigated." | 3.83 | Propofol Prevents Hippocampal Neuronal Loss and Memory Impairment in Cerebral Ischemia Injury Through Promoting PTEN Degradation. ( Chen, X; Du, YM; Liu, D; Wang, YL; Xu, F, 2016) |
| "There is limited data on the safety, hemodynamic profile, and outcome of patients undergoing intra-arterial therapy (IAT) for acute ischemic stroke (AIS) under sedation with dexmedetomidine (DEX) versus propofol (PROP)." | 3.81 | Safety and Hemodynamic Profile of Propofol and Dexmedetomidine Anesthesia during Intra-arterial Acute Stroke Therapy. ( Dupler, S; Farag, E; Gomes, J; Hussain, MS; John, S; Somal, J; Thebo, U, 2015) |
| "To investigate the protective effect of propofol against focal cerebral ischemia/reperfusion (I/R) injury in rats and its relation with gap junction." | 3.81 | [Protective effect of propofol against cerebral ischemic/reperfusion injury may involve inhibition of gap junction]. ( Chen, Y; Dong, S; Fan, Z; Li, Y; Liu, H; Tong, X; Yu, L, 2015) |
| "Propofol is a commonly used intravenous anesthetic that has been demonstrated to be neuroprotective against cerebral ischemia-reperfusion (I/R) injury." | 3.81 | Propofol prevents neuronal mtDNA deletion and cerebral damage due to ischemia/reperfusion injury in rats. ( Chang, FF; Dong, H; Liu, Y; Lu, SJ; Qian, H; Song, CY; Wang, YF; Yang, WC; Yue, ZY, 2015) |
| "It has been shown in our previous study that propofol postconditioning enhanced the activity of phosphatidylinositol-3-kinase (PI3K) and prevented the internalization of GluR2 subunit of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thus provided neuroprotection in cerebral ischemia/reperfusion (I/R) injury." | 3.81 | The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats. ( Liu, S; Wang, G; Wang, H; Zhu, A, 2015) |
| "Propofol, an intravenous anesthetic, inhibits neuronal apoptosis induced by ischemic stroke, protects the brain from ischemia/reperfusion injury and improves neuronal function." | 3.81 | Propofol post-conditioning protects the blood brain barrier by decreasing matrix metalloproteinase-9 and aquaporin-4 expression and improves the neurobehavioral outcome in a rat model of focal cerebral ischemia-reperfusion injury. ( Cao, MH; Ji, FT; Liang, JJ; Miao, LP; Wu, Q, 2015) |
| "The neuroprotective effects of propofol postconditioning in brain ischemia/reperfusion injury may be partially through the induction of the HO-1 expression." | 3.79 | Propofol attenuates cerebral ischemia/reperfusion injury partially using heme oxygenase-1. ( Cang, J; Liang, C; Wang, H; Xue, Z, 2013) |
| "Propofol is an intravenous anesthetic with neuroprotective effects against cerebral ischemia-reperfusion (I/R) injury." | 3.77 | Propofol improved neurobehavioral outcome of cerebral ischemia-reperfusion rats by regulating Bcl-2 and Bax expression. ( Cui, XG; Lu, SJ; Song, CY; Tao, T; Xi, HJ; Yue, ZY; Zhang, TH, 2011) |
| "Several mechanisms are involved in the neuroprotection of propofol against ischemia, but influences of propofol on the binding properties of glutamate receptors and the uptake of glutamate in brain ischemia are not known." | 3.77 | The neuroprotective effect of propofol against brain ischemia mediated by the glutamatergic signaling pathway in rats. ( Cai, J; Hu, Y; Li, L; Li, Q; Li, S; Li, W; Zhang, M, 2011) |
| "Eighty male Sprague-Dawley rats were randomly assigned to treatment groups with propofol administration for 3 h: 36 mg x kg(-1) x h(-1) propofol with or without cerebral ischemia and 72 mg x kg(-1) x h(-1) propofol with or without cerebral ischemia." | 3.75 | Assessment of postischemic neurogenesis in rats with cerebral ischemia and propofol anesthesia. ( Engelhard, K; Lasarzik, I; Orth, C; Schneider, A; Stallmann, S; Tresch, A; Werner, C; Winkelheide, U, 2009) |
| " We compared EEG data before and after clamping of the carotid artery for 2 different anesthesia protocols (isoflurane or propofol) in patients with and without development of cerebral ischemia, making use of SL analysis." | 3.75 | Detection of ischemic electroencephalography changes during carotid endarterectomy using synchronization likelihood analysis. ( Ferrier, C; Kesecioglu, J; Laman, M; Rijsdijk, M; Slooter, A; Stam, K, 2009) |
| " This study was designed to quantitatively evaluate the neuroprotective effects of thiopental, propofol, and halothane on brain ischemia by determining P50, ischemic time necessary for causing 50% neuronal damage." | 3.74 | Quantitative evaluation of the neuroprotective effects of thiopental sodium, propofol, and halothane on brain ischemia in the gerbil: effects of the anesthetics on ischemic depolarization and extracellular glutamate concentration. ( Aoe, H; Kobayashi, M; Morita, K; Takata, K; Takeda, Y; Taninishi, H, 2007) |
| "Propofol (2,6-diisopropylphenol) has been shown to attenuate neuronal injury in a number of experimental conditions, but studies in models of cerebral ischemia have yielded conflicting results." | 3.73 | Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism. ( Adembri, C; Chiarugi, A; Cozzi, A; De Gaudio, RA; Gramigni, E; Pancani, T; Pellegrini-Giampietro, DE; Tani, A; Venturi, L, 2006) |
| "Propofol and midazolam, but not thiopental sodium, may provide protective effects against reperfusion induced injury in rats subjected to focal cerebral ischemia." | 3.72 | Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats. ( Chen, L; Gong, Q; Xiao, C, 2003) |
| "During incomplete cerebral ischemia, the neuroprotective anesthetics sevoflurane and propofol suppressed cerebral increases in norepinephrine and glutamate concentrations." | 3.72 | The effect of sevoflurane and propofol on cerebral neurotransmitter concentrations during cerebral ischemia in rats. ( Blobner, M; Engelhard, K; Hoffman, WE; Kochs, E; Matthes, B; Werner, C, 2003) |
| "To compare the effects of ketamine, midazolam, thiopental, and propofol on brain ischemia by the model of oxygen-glucose deprivation (OGD) in rat cerebral cortical slices." | 3.72 | Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices. ( Chen, HZ; Wang, ZJ; Xue, QS; Yu, BW, 2004) |
| "Propofol reduces neuronal damage from cerebral ischemia when investigated for less than 8 postischemic days." | 3.72 | Influence of propofol on neuronal damage and apoptotic factors after incomplete cerebral ischemia and reperfusion in rats: a long-term observation. ( Eberspächer, E; Engelhard, K; Hollweck, R; Hutzler, P; Kellermann, K; Kochs, E; Pape, M; Stegemann, U; Werner, C, 2004) |
| "To compare the effects of pentobarbital and propofol on the outcome of focal cerebral ischemia model, and to evaluate the availability of propofol in setting the focal cerebral ischemia." | 3.72 | [Comparison of pentobarbital and propofol on the outcome of focal cerebral ischemia model in rats]. ( Kang, QY; Li, J; Liu, Y; Zhang, PB; Zhao, JJ, 2004) |
| " We measured the levels of malondialdehyde as a marker of lipid peroxidation in ischemic tissue, and the results indicate that propofol plays a role in the inhibition of neuronal death induced by brain ischemia." | 3.71 | Neuroprotective effects of propofol following global cerebral ischemia in rats. ( Akdemir, G; Ergün, R; Ergüngör, F; Sen, S; Taşçi, A, 2002) |
| "It has been suggested that propofol has the protective effect on cerebral ischemia-reperfusion injury." | 3.70 | Effectiveness of propofol pretreatment on the extent of deranged cerebral mitochondrial oxidative enzyme system after incomplete forebrain ischemia/reperfusion in rats. ( Chung, C; Lee, Y; Oh, YS, 2000) |
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 3.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "This study was designed to test the hypothesis that propofol, which possesses antioxidant properties, would produce greater protection than isoflurane in cerebral ischaemia reperfusion injury, at dose levels that produced similar affects on brain electrical activity." | 3.69 | Propofol neuroprotection in a rat model of ischaemia reperfusion injury. ( Jones, JG; Matta, BF; Menon, DK; Tisavipat, N; Young, Y, 1997) |
| "The increment of GABAergic inhibitory activity, the reduction of metabolic rate and oxygen consumption induced by propofol on the neuronal components of brain structures, and its antioxidant potential have supported the possible beneficial effects of this drug against brain damage elicited by cerebral ischemia." | 3.69 | Effects of propofol on alterations of multineuronal activity of limbic and mesencephalic structures and neurological deficit elicited by acute global cerebral ischemia. ( Antonio-Ocampo, A; Cervantes, M; Chávez-Carrillo, I; Contreras-Gomez, A; Ruelas, R, 1995) |
| "As propofol has been reported to have effects similar to those of thiopentone on cerebral blood flow, intracranial pressure and cerebral metabolic rate, we postulated that it might also have a protective effect on focal cerebral ischemia." | 3.69 | Propofol does not reduce infarct volume in rats undergoing permanent middle cerebral artery occlusion. ( Chang, CL; Cheng, JT; Huang, SJ; Lai, YY; Tsai, YC, 1994) |
| "This study compares the effects of propofol and fentanyl/N2O on spontaneous brain electrical activity, neurologic outcome, and neuronal damage due to incomplete cerebral ischemia in rats." | 3.68 | The effects of propofol on brain electrical activity, neurologic outcome, and neuronal damage following incomplete ischemia in rats. ( Albrecht, RF; Hoffman, WE; Kochs, E; Schulte am Esch, J; Thomas, C; Werner, C, 1992) |
| "Given the complex pathophysiology of cerebral ischemia and hypoxia, a multimodal approach to neuroprotective strategies seems sensible." | 2.52 | Update on anesthetic neuroprotection. ( Absalom, A; Zwerus, R, 2015) |
| "Cerebral ischemia is characterized by continued neuronal loss for a long time after the initial ischemic insult." | 2.43 | Neuroprotective effects of anesthetic agents. ( Furuya, H; Kawaguchi, M; Patel, PM, 2005) |
| "Propofol is an intravenous anesthetic that is commonly used during intravascular embolectomy following acute ischemic stroke." | 1.56 | Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke. ( Cui, V; Tian, D; Wang, H; Wang, Y; Wei, C; Wu, A; Yue, Y; Zhu, Y, 2020) |
| "It has been recognized to be critical in cerebral ischemia-reperfusion injury, and reactive oxygen species (ROS) can induce parthanatos." | 1.48 | Propofol inhibits parthanatos via ROS-ER-calcium-mitochondria signal pathway in vivo and vitro. ( Chen, Y; Hu, J; Liu, Y; Liu, Z; Pang, Q; Song, R; Tang, J; Zhong, H; Zhuang, J, 2018) |
| "Pretreatment with propofol attenuates autogenous orthotropic liver transplantation induces hippocampal injury via JAK2/STAT3 pathway." | 1.46 | Propofol postconditioning attenuates hippocampus ischemia-reperfusion injury via modulating JAK2/STAT3 pathway in rats after autogenous orthotropic liver transplantation. ( Du, H; Gu, X; Jia, L; Li, S; Sheng, M; Wang, F; Wang, G; Weng, Y; Yu, W, 2017) |
| "A rat model of asphyxia cardiac arrest (CA) was created followed by cardiopulmonary resuscitation." | 1.42 | Inhibition of microglial activation contributes to propofol-induced protection against post-cardiac arrest brain injury in rats. ( Feng, DY; Liang, LR; Liu, B; Lu, R; Wang, W; Zhang, H, 2015) |
| "Propofol has been shown to attenuate brain injury in experimental ischemia models, but few studies have focused on the direct effect of propofol on mitochondrial dysfunction." | 1.40 | The effects of propofol on mitochondrial dysfunction following focal cerebral ischemia-reperfusion in rats. ( Li, B; Li, J; Li, XT; Qi, SH; Yu, W, 2014) |
| "Propofol has been shown to attenuate ischemic brain damage via inhibiting neuronal apoptosis." | 1.40 | Propofol reduces inflammatory reaction and ischemic brain damage in cerebral ischemia in rats. ( Chen, JP; Chen, Y; Shi, SS; Tu, XK; Yang, WZ, 2014) |
| "Propofol treatment reduced infarct volume and improved the neurological functions." | 1.39 | Propofol protects against focal cerebral ischemia via inhibition of microglia-mediated proinflammatory cytokines in a rat model of experimental stroke. ( Liu, F; Tan, Y; Tang, X; Wu, X; Yang, Z; Zhou, R, 2013) |
| "A transient global cerebral ischemia-reperfusion (I/R) model was produced with a 10-min, 2-vessel occlusion." | 1.39 | Propofol prevents cerebral ischemia-triggered autophagy activation and cell death in the rat hippocampus through the NF-κB/p53 signaling pathway. ( Cui, DR; Jiang, W; Qi, AH; Wang, L; Zhang, XL; Zhou, QH, 2013) |
| "When propofol EDTA was given intravenously 10 mins before cerebral ischemia, the zinc concentration decreased significantly in the cortical area, but not in the subcortex." | 1.35 | Propofol exerts greater neuroprotection with disodium edetate than without it. ( Hara, H; Hasegawa, T; Iwama, T; Kotani, Y; Nagase, H; Nakajima, Y; Satoh, M; Shimazawa, M; Yoshimura, S, 2008) |
| "Propofol has been demonstrated to ameliorate cerebral ischemic injury and attenuate changes in multiple links of molecular reaction included in the paths to apoptosis." | 1.35 | Effect of propofol on pathologic time-course and apoptosis after cerebral ischemia-reperfusion injury. ( Chen, L; Jiang, H; Xue, Z, 2008) |
| "Cerebral ischemia was induced in awake Wistar rats by a local intracerebral injection of the potent vasoconstrictor, endothelin (6 pmol in 3 microl) into the striatum." | 1.32 | Propofol neuroprotection in cerebral ischemia and its effects on low-molecular-weight antioxidants and skilled motor tasks. ( Bayona, NA; Cechetto, DF; Gelb, AW; Jiang, Z; Urquhart, BL; Wilson, JX, 2004) |
| "Fetal brain ischemia was induced by clamping the utero-ovarian artery bilaterally for 30 min and reperfusion was achieved by removing the clamps for 2 h." | 1.32 | Maternal treatment with propofol attenuates lipid peroxidation after transient intrauterine ischemia in the neonatal rat brain. ( Beskonakli, E; Kaptanoglu, E; Kilinc, K; Okutan, O; Solaroglu, A; Solaroglu, I, 2004) |
| "During cerebral ischemia, excess of glutamate release and dysfunction of its high affinity transport induce an accumulation of extracellular glutamate, which plays an important role in neuronal death." | 1.32 | Neuroprotective effects of propofol in a model of ischemic cortical cell cultures: role of glutamate and its transporters. ( Bruder, NJ; Gouin, FM; Guillet, BA; Masmejean, FM; Nieoullon, AL; Pisano, PM; Velly, LJ, 2003) |
| "Thiopental and propofol were present 10 min before and during the period of OGD." | 1.31 | The effects of thiopental and propofol on cell swelling induced by oxygen/glucose deprivation in the CA1 pyramidal cell layer of rat hippocampal slices. ( Fujihara, H; Qi, S; Shimoji, K; Taga, K; Wu, C; Zhan, RZ, 2002) |
| "Propofol has been known to suppress glucose metabolism in the brain and possess neuroprotective properties in cerebral ischaemia." | 1.31 | Effects of propofol on lactate accumulation and oedema formation in focal cerebral ischaemia in hyperglycaemic rats. ( Arai, T; Fukuda, K; Inubushi, T; Ishii, H; Morikawa, S; Segawa, H, 2002) |
| "Forebrain ischemia was produced by bilaterally occluding the common carotid arteries for 10 minutes; then the blood supply to the brain was restored." | 1.29 | Effect of 2,6-diisopropylphenol on the delayed hippocampal cell loss following transient forebrain ischemia in the gerbil. ( Arcadi, FA; Costa, G; De Luca, R; Rapisarda, A; Trimarchi, GR, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (14.46) | 18.2507 |
| 2000's | 30 (36.14) | 29.6817 |
| 2010's | 34 (40.96) | 24.3611 |
| 2020's | 7 (8.43) | 2.80 |
| Authors | Studies |
|---|---|
| Sousa, GC | 1 |
| Fernandes, MV | 1 |
| Cruz, FF | 1 |
| Antunes, MA | 1 |
| da Silva, CM | 1 |
| Takyia, C | 1 |
| Battaglini, D | 1 |
| Samary, CS | 1 |
| Robba, C | 2 |
| Pelosi, P | 1 |
| Rocco, PRM | 1 |
| Silva, PL | 1 |
| Crimmins, D | 2 |
| Ryan, E | 2 |
| Shah, D | 2 |
| Lwin, TN | 2 |
| Ayotte, S | 2 |
| Redmond, K | 2 |
| Highton, D | 2 |
| Wang, Y | 2 |
| Tian, D | 2 |
| Wei, C | 2 |
| Cui, V | 1 |
| Wang, H | 5 |
| Zhu, Y | 2 |
| Wu, A | 2 |
| Yue, Y | 1 |
| Wang, C | 1 |
| Wei, Y | 1 |
| Yuan, Y | 1 |
| Yu, Y | 1 |
| Xie, K | 1 |
| Dong, B | 1 |
| Shi, Y | 1 |
| Wang, G | 4 |
| Simonato, D | 1 |
| Ganau, M | 1 |
| Feltracco, P | 1 |
| Causin, F | 1 |
| Munari, M | 1 |
| Bortolato, A | 1 |
| Chen, Y | 4 |
| Li, Z | 1 |
| Zhao, Y | 1 |
| Qu, M | 1 |
| Pan, Y | 1 |
| Sun, B | 1 |
| Ou, H | 1 |
| Ren, F | 1 |
| Guan, Y | 1 |
| Huan, Y | 1 |
| Cai, H | 1 |
| Zheng, Y | 1 |
| Bu, J | 1 |
| Yu, L | 2 |
| Chen, J | 1 |
| Liu, H | 3 |
| Rasmussen, M | 2 |
| Simonsen, CZ | 1 |
| Sørensen, LH | 1 |
| Dyrskog, S | 1 |
| Rusy, DA | 1 |
| Sharma, D | 1 |
| Juul, N | 2 |
| Yu, W | 3 |
| Gao, D | 1 |
| Jin, W | 1 |
| Liu, S | 2 |
| Qi, S | 2 |
| Zhong, H | 1 |
| Song, R | 1 |
| Pang, Q | 1 |
| Liu, Y | 4 |
| Zhuang, J | 1 |
| Hu, J | 2 |
| Liu, Z | 1 |
| Tang, J | 1 |
| Cardim, D | 1 |
| Matta, B | 1 |
| Tytherleigh-Strong, G | 1 |
| Kang, N | 1 |
| Schmidt, B | 1 |
| Donnelly, J | 1 |
| Calviello, L | 1 |
| Smielewski, P | 1 |
| Czosnyka, M | 1 |
| Xu, F | 2 |
| Ma, R | 1 |
| Zhang, G | 1 |
| Wang, S | 1 |
| Yin, J | 1 |
| Wang, E | 1 |
| Xiong, E | 1 |
| Zhang, Q | 2 |
| Li, Y | 2 |
| Liang, C | 1 |
| Cang, J | 1 |
| Xue, Z | 2 |
| Cui, DR | 1 |
| Wang, L | 1 |
| Jiang, W | 1 |
| Qi, AH | 1 |
| Zhou, QH | 1 |
| Zhang, XL | 1 |
| Cabezón, L | 1 |
| Nogueira, C | 1 |
| Ramos, L | 1 |
| Vázquez-Fidalgo, A | 1 |
| Li, J | 3 |
| Li, XT | 1 |
| Qi, SH | 1 |
| Li, B | 1 |
| Zhou, R | 1 |
| Yang, Z | 1 |
| Tang, X | 1 |
| Tan, Y | 1 |
| Wu, X | 1 |
| Liu, F | 1 |
| Ward, JM | 1 |
| Buslov, AM | 1 |
| Vallender, EJ | 1 |
| Shi, SS | 1 |
| Yang, WZ | 1 |
| Chen, JP | 1 |
| Tu, XK | 1 |
| Ho, L | 1 |
| Spanger, M | 1 |
| Hayward, P | 1 |
| McNicol, L | 1 |
| Weinberg, L | 1 |
| Yue, ZY | 3 |
| Dong, H | 2 |
| Wang, YF | 1 |
| Song, CY | 3 |
| Yang, WC | 2 |
| Qian, H | 2 |
| Lu, SJ | 2 |
| Chang, FF | 1 |
| Zhu, A | 1 |
| Ji, FT | 1 |
| Liang, JJ | 1 |
| Miao, LP | 1 |
| Wu, Q | 1 |
| Cao, MH | 1 |
| Wang, W | 1 |
| Lu, R | 1 |
| Feng, DY | 1 |
| Liang, LR | 1 |
| Liu, B | 1 |
| Zhang, H | 1 |
| Zwerus, R | 1 |
| Absalom, A | 1 |
| John, S | 1 |
| Somal, J | 1 |
| Thebo, U | 1 |
| Hussain, MS | 1 |
| Farag, E | 1 |
| Dupler, S | 1 |
| Gomes, J | 1 |
| Fan, Z | 1 |
| Tong, X | 1 |
| Dong, S | 1 |
| Ulbrich, F | 1 |
| Eisert, L | 1 |
| Buerkle, H | 1 |
| Goebel, U | 1 |
| Schallner, N | 1 |
| Tao, T | 2 |
| Li, CL | 1 |
| Zeng, XZ | 1 |
| Chen, X | 1 |
| Du, YM | 1 |
| Liu, D | 1 |
| Wang, YL | 1 |
| Jia, L | 1 |
| Wang, F | 1 |
| Gu, X | 1 |
| Weng, Y | 1 |
| Sheng, M | 1 |
| Li, S | 2 |
| Du, H | 1 |
| Shintani, N | 1 |
| Ishiyama, T | 1 |
| Kotoda, M | 1 |
| Asano, N | 1 |
| Sessler, DI | 1 |
| Matsukawa, T | 1 |
| Wang, DF | 2 |
| Fu, JQ | 1 |
| Sun, P | 1 |
| Zhang, S | 1 |
| Tian, Y | 1 |
| Zhang, J | 1 |
| Lasarzik, I | 1 |
| Winkelheide, U | 1 |
| Stallmann, S | 1 |
| Orth, C | 1 |
| Schneider, A | 1 |
| Tresch, A | 1 |
| Werner, C | 5 |
| Engelhard, K | 4 |
| Rijsdijk, M | 1 |
| Ferrier, C | 1 |
| Laman, M | 1 |
| Kesecioglu, J | 1 |
| Stam, K | 1 |
| Slooter, A | 1 |
| Cavus, E | 1 |
| Meybohm, P | 1 |
| Doerges, V | 1 |
| Hoecker, J | 1 |
| Betz, M | 1 |
| Hanss, R | 1 |
| Steinfath, M | 1 |
| Bein, B | 1 |
| Dippmann, C | 1 |
| Winge, S | 1 |
| Nielsen, HB | 1 |
| Shang, Y | 3 |
| Zhao, F | 1 |
| Fan, J | 1 |
| Gu, PF | 1 |
| Cai, J | 1 |
| Hu, Y | 1 |
| Li, W | 1 |
| Li, L | 1 |
| Zhang, M | 1 |
| Li, Q | 1 |
| Xi, HJ | 1 |
| Zhang, TH | 1 |
| Cui, XG | 1 |
| Luo, M | 1 |
| Li, C | 1 |
| Shu, L | 1 |
| Li, T | 1 |
| Han, S | 1 |
| Ji, F | 1 |
| Pan, C | 1 |
| Zhang, B | 1 |
| Yao, N | 1 |
| Song, X | 1 |
| Liu, XL | 1 |
| Daskalopoulos, R | 1 |
| Korcok, J | 1 |
| Tao, L | 1 |
| Wilson, JX | 2 |
| Chen, L | 2 |
| Gong, Q | 1 |
| Xiao, C | 1 |
| Velly, LJ | 1 |
| Guillet, BA | 1 |
| Masmejean, FM | 1 |
| Nieoullon, AL | 1 |
| Bruder, NJ | 1 |
| Gouin, FM | 1 |
| Pisano, PM | 1 |
| Hoffman, WE | 2 |
| Matthes, B | 1 |
| Blobner, M | 2 |
| Kochs, E | 4 |
| Xue, QS | 1 |
| Yu, BW | 1 |
| Wang, ZJ | 1 |
| Chen, HZ | 1 |
| Solaroglu, I | 1 |
| Okutan, O | 1 |
| Solaroglu, A | 1 |
| Kaptanoglu, E | 1 |
| Beskonakli, E | 1 |
| Kilinc, K | 1 |
| Bayona, NA | 1 |
| Gelb, AW | 2 |
| Jiang, Z | 1 |
| Urquhart, BL | 1 |
| Cechetto, DF | 1 |
| Eberspächer, E | 2 |
| Pape, M | 2 |
| Hutzler, P | 2 |
| Østergaard, L | 1 |
| Gyldensted, C | 1 |
| Poulsen, PV | 1 |
| Cold, GE | 1 |
| Stegemann, U | 1 |
| Kellermann, K | 1 |
| Hollweck, R | 1 |
| Kawaguchi, M | 1 |
| Furuya, H | 1 |
| Patel, PM | 1 |
| Zhang, PB | 1 |
| Zhao, JJ | 1 |
| Kang, QY | 1 |
| Adembri, C | 1 |
| Venturi, L | 1 |
| Tani, A | 1 |
| Chiarugi, A | 1 |
| Gramigni, E | 1 |
| Cozzi, A | 1 |
| Pancani, T | 1 |
| De Gaudio, RA | 1 |
| Pellegrini-Giampietro, DE | 1 |
| Fernández Sánchez, LJ | 1 |
| Pérez González, R | 1 |
| Guasch Arévalo, E | 1 |
| Martín Reyes, R | 1 |
| Gilsanz Rodríguez, F | 1 |
| Kobayashi, M | 1 |
| Takeda, Y | 1 |
| Taninishi, H | 1 |
| Takata, K | 1 |
| Aoe, H | 1 |
| Morita, K | 1 |
| Kotani, Y | 1 |
| Nakajima, Y | 1 |
| Hasegawa, T | 1 |
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| Rapisarda, A | 1 |
| De Luca, R | 1 |
| Trimarchi, GR | 1 |
| Costa, G | 1 |
| Young, Y | 1 |
| Menon, DK | 1 |
| Tisavipat, N | 1 |
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| Fujihara, H | 1 |
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| Ergün, R | 1 |
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| Taşçi, A | 1 |
| Ergüngör, F | 1 |
| Ishii, H | 1 |
| Arai, T | 1 |
| Segawa, H | 1 |
| Morikawa, S | 1 |
| Inubushi, T | 1 |
| Fukuda, K | 1 |
| Taniguchi, M | 1 |
| Nadstawek, J | 1 |
| Pechstein, U | 1 |
| Schramm, J | 1 |
| Ridenour, TR | 1 |
| Warner, DS | 1 |
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| Gionet, TX | 1 |
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| Albrecht, RF | 1 |
| Schulte am Esch, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Vasopressors on Brain Oxygenation and Microcirculation in Anesthetized Patients With Cerebral Tumors[NCT02713087] | Phase 4 | 48 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Delirium Reduction by Volatile Anesthesia in Cardiac Surgery: Prospective, Randomized, Single-blinded Study[NCT03729011] | Phase 4 | 672 participants (Anticipated) | Interventional | 2019-01-09 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for propofol and Cerebral Ischemia
| Article | Year |
|---|---|
Update on anesthetic neuroprotection.
Topics: Anesthetics, Inhalation; Barbiturates; Brain Ischemia; Humans; Hypnotics and Sedatives; Ischemic Pre | 2015 |
Neuroprotective effects of anesthetic agents.
Topics: Anesthetics; Animals; Apoptosis; Barbiturates; Brain Ischemia; Humans; Isoflurane; Neuroprotective A | 2005 |
Therapeutic coma or neuroprotection by anaesthetics.
Topics: Anesthetics; Animals; Barbiturates; Brain; Brain Ischemia; Cardiopulmonary Bypass; Drug Evaluation; | 2000 |
80 other studies available for propofol and Cerebral Ischemia
| Article | Year |
|---|---|
Comparative effects of dexmedetomidine and propofol on brain and lung damage in experimental acute ischemic stroke.
Topics: Animals; Brain; Brain Ischemia; Dexmedetomidine; Disease Models, Animal; Endothelial Cells; Hypnotic | 2021 |
The Effect of Anesthetic Agent and Mean Arterial Pressure on Functional Outcome After General Anesthesia for Endovascular Thrombectomy.
Topics: Anesthesia, General; Anesthetics; Arterial Pressure; Brain Ischemia; Endovascular Procedures; Humans | 2024 |
The Effect of Anesthetic Agent and Mean Arterial Pressure on Functional Outcome After General Anesthesia for Endovascular Thrombectomy.
Topics: Anesthesia, General; Anesthetics; Arterial Pressure; Brain Ischemia; Endovascular Procedures; Humans | 2024 |
The Effect of Anesthetic Agent and Mean Arterial Pressure on Functional Outcome After General Anesthesia for Endovascular Thrombectomy.
Topics: Anesthesia, General; Anesthetics; Arterial Pressure; Brain Ischemia; Endovascular Procedures; Humans | 2024 |
The Effect of Anesthetic Agent and Mean Arterial Pressure on Functional Outcome After General Anesthesia for Endovascular Thrombectomy.
Topics: Anesthesia, General; Anesthetics; Arterial Pressure; Brain Ischemia; Endovascular Procedures; Humans | 2024 |
Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke.
Topics: alpha-Synuclein; Animals; Behavior, Animal; Brain Infarction; Brain Ischemia; Disease Models, Animal | 2020 |
The role of PI3K-mediated AMPA receptor changes in post-conditioning of propofol in brain protection.
Topics: Animals; Brain Ischemia; Chromones; Hippocampus; Ischemic Postconditioning; Male; Morpholines; Neuro | 2019 |
Mechanical thrombectomy in a pediatric patient with sedation aided by contralateral intra-arterial propofol injection: feasibility in an extreme condition.
Topics: Adolescent; Brain Ischemia; Child; Feasibility Studies; Humans; Injections, Intra-Arterial; Male; Pr | 2021 |
Protective Effects of Propofol on Rats with Cerebral Ischemia-Reperfusion Injury Via the PI3K/Akt Pathway.
Topics: Animals; Autophagy; Brain; Brain Ischemia; Cells, Cultured; Cytokines; Male; Microglia; Neuroprotect | 2021 |
Propofol Protects Regulatory T Cells, Suppresses Neurotoxic Astrogliosis, and Potentiates Neurological Recovery After Ischemic Stroke.
Topics: Brain Ischemia; Gliosis; Humans; Ischemic Stroke; Propofol; Recovery of Function; Stroke; T-Lymphocy | 2021 |
Propofol Protects against Cerebral Ischemia/Reperfusion Injury by Down-Regulating Long Noncoding RNA SNHG14.
Topics: Animals; Apoptosis; Brain Ischemia; Glucose; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred | 2021 |
Nobiletin improves propofol-induced neuroprotection via regulating Akt/mTOR and TLR 4/NF-κB signaling in ischemic brain injury in rats.
Topics: Animals; Apoptosis; Behavior, Animal; Brain Ischemia; Cytokines; Flavones; Infarction, Middle Cerebr | 2017 |
Anaesthesia practices for endovascular therapy of acute ischaemic stroke: a Nordic survey.
Topics: Anesthesia; Anesthetics; Anesthetics, Intravenous; Blood Pressure; Brain Ischemia; Conscious Sedatio | 2017 |
Propofol Prevents Oxidative Stress by Decreasing the Ischemic Accumulation of Succinate in Focal Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Brain Ischemia; Ischemia; Male; Membrane Potential, Mitochondrial; Mitochondria; Neuroprote | 2018 |
Propofol inhibits parthanatos via ROS-ER-calcium-mitochondria signal pathway in vivo and vitro.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Brain Ischemia; Calcium; Cell Death; Cell Line; | 2018 |
Cerebrovascular assessment of patients undergoing shoulder surgery in beach chair position using a multiparameter transcranial Doppler approach.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Arterial Pressure; Blood Flow Velocity; Brai | 2019 |
Estrogen and propofol combination therapy inhibits endoplasmic reticulum stress and remarkably attenuates cerebral ischemia-reperfusion injury and OGD injury in hippocampus.
Topics: Animals; Brain Ischemia; Cell Hypoxia; Drug Therapy, Combination; Endoplasmic Reticulum Stress; Estr | 2018 |
Propofol attenuates cerebral ischemia/reperfusion injury partially using heme oxygenase-1.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Biomarkers; Blotting, Western; Brain Ischemia; Heme Ox | 2013 |
Propofol prevents cerebral ischemia-triggered autophagy activation and cell death in the rat hippocampus through the NF-κB/p53 signaling pathway.
Topics: Animals; Autophagy; Brain Ischemia; Cell Death; Dose-Response Relationship, Drug; Genes, p53; Hippoc | 2013 |
[General anesthesia for an urgent cesarean in a pregnant woman with an acute cerebrovascular accident].
Topics: Adult; Anesthesia, Obstetrical; Anesthetics, General; Balanced Anesthesia; Brain Ischemia; Carotid A | 2014 |
The effects of propofol on mitochondrial dysfunction following focal cerebral ischemia-reperfusion in rats.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Male; Membrane Potential, Mitochondrial; Mitochondria; Neu | 2014 |
Propofol protects against focal cerebral ischemia via inhibition of microglia-mediated proinflammatory cytokines in a rat model of experimental stroke.
Topics: Animals; Biomarkers; Brain Ischemia; Cytokines; Disease Models, Animal; Gene Expression; Infarction, | 2013 |
Twinning and survivorship of captive common marmosets (Callithrix jacchus) and cotton-top tamarins (Saguinus oedipus).
Topics: Animals; Animals, Laboratory; Brain Ischemia; Bupivacaine; Callithrix; Electroencephalography; Eutha | 2014 |
Propofol reduces inflammatory reaction and ischemic brain damage in cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Cyclooxygenase 2; Infarction, Middle Cerebral Artery; | 2014 |
Missed carotid artery cannulation: a line crossed and lessons learnt.
Topics: Aged, 80 and over; Anesthetics, Intravenous; Brain Ischemia; Carotid Arteries; Carotid Artery Injuri | 2014 |
Propofol prevents neuronal mtDNA deletion and cerebral damage due to ischemia/reperfusion injury in rats.
Topics: Animals; Brain Ischemia; Disease Models, Animal; DNA, Mitochondrial; Hippocampus; Male; Membrane Pot | 2015 |
The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats.
Topics: Acute Disease; Animals; Brain Ischemia; CA1 Region, Hippocampal; Carboxylic Acids; Cell Survival; Di | 2015 |
Propofol post-conditioning protects the blood brain barrier by decreasing matrix metalloproteinase-9 and aquaporin-4 expression and improves the neurobehavioral outcome in a rat model of focal cerebral ischemia-reperfusion injury.
Topics: Anesthetics, Intravenous; Animals; Aquaporin 4; Blood-Brain Barrier; Brain; Brain Ischemia; MAP Kina | 2015 |
Inhibition of microglial activation contributes to propofol-induced protection against post-cardiac arrest brain injury in rats.
Topics: Adenosine Triphosphate; Animals; Asphyxia; Brain Ischemia; CA1 Region, Hippocampal; Cardiopulmonary | 2015 |
Safety and Hemodynamic Profile of Propofol and Dexmedetomidine Anesthesia during Intra-arterial Acute Stroke Therapy.
Topics: Aged; Aged, 80 and over; Blood Pressure; Brain Ischemia; Dexmedetomidine; Diffusion Magnetic Resonan | 2015 |
[Protective effect of propofol against cerebral ischemic/reperfusion injury may involve inhibition of gap junction].
Topics: Animals; bcl-2-Associated X Protein; Brain; Brain Ischemia; Connexin 43; Gap Junctions; Infarction, | 2015 |
Propofol, but not ketamine or midazolam, exerts neuroprotection after ischaemic injury by inhibition of Toll-like receptor 4 and nuclear factor kappa-light-chain-enhancer of activated B-cell signalling: A combined in vitro and animal study.
Topics: Analgesics; Animals; B-Lymphocytes; Brain Ischemia; Cell Line, Tumor; Dose-Response Relationship, Dr | 2016 |
Protective effects of propofol against whole cerebral ischemia/reperfusion injury in rats through the inhibition of the apoptosis-inducing factor pathway.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; bcl-2-Associated X Protein; Brain Ischemia; Hippocamp | 2016 |
Propofol Prevents Hippocampal Neuronal Loss and Memory Impairment in Cerebral Ischemia Injury Through Promoting PTEN Degradation.
Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Male; Memory Disorders; Neurons; Neuroprotective A | 2016 |
Propofol postconditioning attenuates hippocampus ischemia-reperfusion injury via modulating JAK2/STAT3 pathway in rats after autogenous orthotropic liver transplantation.
Topics: Animals; Apoptosis; Brain Ischemia; Hippocampus; Janus Kinase 2; Liver Transplantation; Male; Neurop | 2017 |
The effects of Y-27632 on pial microvessels during global brain ischemia and reperfusion in rabbits.
Topics: Amides; Animals; Blood Glucose; Blood Pressure; Brain Ischemia; Microvessels; Pia Mater; Propofol; P | 2017 |
[A comparison of protective effect of propofol and edaravone pretreatment against cerebral ischemia-reperfusion injury].
Topics: Animals; Antipyrine; Apoptosis; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Cortex; Eda | 2008 |
Effects of propofol on the mRNA expression of toll-like receptor 4 in BV-2 cells during mimic ischemia-reperfusion injury in vitro.
Topics: Animals; Brain Ischemia; Cell Line; Mice; Microglia; Neuroprotective Agents; NF-kappa B; Propofol; R | 2008 |
Assessment of postischemic neurogenesis in rats with cerebral ischemia and propofol anesthesia.
Topics: Anesthesia, Intravenous; Animals; Brain Ischemia; Cell Differentiation; Male; Neurogenesis; Propofol | 2009 |
Detection of ischemic electroencephalography changes during carotid endarterectomy using synchronization likelihood analysis.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Anesthesia, General; Anesthetics, Inhalation; Anesthetic | 2009 |
Effects of cerebral hypoperfusion on bispectral index: a randomised, controlled animal experiment during haemorrhagic shock.
Topics: Anesthetics, Intravenous; Animals; Arginine Vasopressin; Blood Flow Velocity; Blood Pressure; Brain; | 2010 |
Severe cerebral desaturation during shoulder arthroscopy in the beach-chair position.
Topics: Anesthesia, General; Arthroscopy; Blood Gas Monitoring, Transcutaneous; Brain Ischemia; Cerebrovascu | 2010 |
[Effect of propofol on iNOS expression in hippocampus after global cerebral ischemia/reperfusion injury of rats].
Topics: Animals; Brain Ischemia; Hippocampus; Male; Nitric Oxide Synthase Type II; Propofol; Rats; Rats, Wis | 2007 |
[Effect of propofol on glutamate, ascorbic acid release in hippocampus during global cerebral ischemia/reperfusion in rats].
Topics: Animals; Ascorbic Acid; Brain Ischemia; Glutamic Acid; Hippocampus; Male; Propofol; Rats; Rats, Wist | 2006 |
[The effect of propofol on astrocyte GFAP expression after the focal cerebral ischemia].
Topics: Animals; Astrocytes; Brain Ischemia; Glial Fibrillary Acidic Protein; Neuroprotective Agents; Propof | 2009 |
The neuroprotective effect of propofol against brain ischemia mediated by the glutamatergic signaling pathway in rats.
Topics: Anesthetics, Intravenous; Animals; Brain Ischemia; Glutamic Acid; Male; Neurons; Neuroprotective Age | 2011 |
Propofol improved neurobehavioral outcome of cerebral ischemia-reperfusion rats by regulating Bcl-2 and Bax expression.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Brain Is | 2011 |
Propofol post-conditioning induced long-term neuroprotection and reduced internalization of AMPAR GluR2 subunit in a rat model of focal cerebral ischemia/reperfusion.
Topics: Anesthetics, Intravenous; Animals; Antimetabolites; Behavior, Animal; Blotting, Western; Brain Ische | 2011 |
Inhibition of neuron-specific CREB dephosphorylation is involved in propofol and ketamine-induced neuroprotection against cerebral ischemic injuries of mice.
Topics: Animals; Blotting, Western; Brain Ischemia; Cyclic AMP Response Element-Binding Protein; Electrophor | 2012 |
[Neuroprotective effects of combined pretreatment with edaravone and propofol on neonatal rat cerebral cortical neurons with ischemia/reperfusion injury in vitro].
Topics: Animals; Antipyrine; Apoptosis; Brain Ischemia; Cell Survival; Cells, Cultured; Cerebral Cortex; Eda | 2012 |
Accumulation of intracellular ascorbate from dehydroascorbic acid by astrocytes is decreased after oxidative stress and restored by propofol.
Topics: Animals; Animals, Newborn; Ascorbic Acid; Astrocytes; Biological Transport, Active; Brain; Brain Isc | 2002 |
Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Edema; Brain Ischemia; Excitatory Amino Acids; Male; M | 2003 |
Neuroprotective effects of propofol in a model of ischemic cortical cell cultures: role of glutamate and its transporters.
Topics: Amino Acid Transport System X-AG; Amino Acids; Anesthetics, Intravenous; Animals; Brain Ischemia; Ce | 2003 |
The effect of sevoflurane and propofol on cerebral neurotransmitter concentrations during cerebral ischemia in rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Aspartic Acid; Blood Gas Analysis; Blood | 2003 |
Effects of ketamine, midazolam, thiopental, and propofol on brain ischemia injury in rat cerebral cortical slices.
Topics: Anesthetics, Intravenous; Animals; Brain Ischemia; Cell Hypoxia; Cerebral Cortex; Glucose; In Vitro | 2004 |
Maternal treatment with propofol attenuates lipid peroxidation after transient intrauterine ischemia in the neonatal rat brain.
Topics: Animals; Brain Ischemia; Female; Fetal Diseases; Lipid Peroxidation; Neuroprotective Agents; Pregnan | 2004 |
Propofol neuroprotection in cerebral ischemia and its effects on low-molecular-weight antioxidants and skilled motor tasks.
Topics: Animals; Antioxidants; Brain Ischemia; Cells, Cultured; Drug Administration Schedule; Male; Motor Sk | 2004 |
Sevoflurane and propofol influence the expression of apoptosis-regulating proteins after cerebral ischaemia and reperfusion in rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Apoptosis; bcl-2-Associated X Protein; B | 2004 |
Do indomethacin and propofol cause cerebral ischemic damage? Diffusion-weighted magnetic resonance imaging in patients undergoing craniotomy for brain tumors.
Topics: Adult; Aged; Brain Ischemia; Brain Neoplasms; Craniotomy; Diffusion; Female; Humans; Indomethacin; M | 2004 |
Influence of propofol on neuronal damage and apoptotic factors after incomplete cerebral ischemia and reperfusion in rats: a long-term observation.
Topics: Animals; Apoptosis; Brain Ischemia; Caspase 3; Caspases; Male; Neurons; Neuroprotective Agents; Prop | 2004 |
[Comparison of pentobarbital and propofol on the outcome of focal cerebral ischemia model in rats].
Topics: Adjuvants, Anesthesia; Anesthetics, Intravenous; Animals; Brain Ischemia; Disease Models, Animal; In | 2004 |
Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism.
Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Brain Ischemia; Calcium; Glucose; Hippocampus; | 2006 |
[Perioperative treatment of a pregnant woman with recent cerebral infarction secondary to noncompaction cardiomyopathy].
Topics: Adrenergic beta-Antagonists; Androstanols; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, | 2006 |
Quantitative evaluation of the neuroprotective effects of thiopental sodium, propofol, and halothane on brain ischemia in the gerbil: effects of the anesthetics on ischemic depolarization and extracellular glutamate concentration.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Brain Ischemia; Electroencephalog | 2007 |
Propofol exerts greater neuroprotection with disodium edetate than without it.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Benzimidazoles; Brain Ischemia; Cell Count; Cell Survi | 2008 |
Effect of propofol on pathologic time-course and apoptosis after cerebral ischemia-reperfusion injury.
Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Edema; Male; Neurons; Propofol; Proto-On | 2008 |
Propofol protects cultured rat hippocampal neurons against N-methyl-D-aspartate receptor-mediated glutamate toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cells, Cultured; | 1994 |
Propofol does not reduce infarct volume in rats undergoing permanent middle cerebral artery occlusion.
Topics: Animals; Brain Ischemia; Cerebral Arteries; Cerebral Infarction; Constriction; Male; Propofol; Rats; | 1994 |
Effects of propofol on alterations of multineuronal activity of limbic and mesencephalic structures and neurological deficit elicited by acute global cerebral ischemia.
Topics: Acute Disease; Animals; Antioxidants; Brain Diseases; Brain Ischemia; Cats; Limbic System; Mesenceph | 1995 |
Effect of 2,6-diisopropylphenol on the delayed hippocampal cell loss following transient forebrain ischemia in the gerbil.
Topics: Animals; Brain Ischemia; Cell Death; Cell Survival; Disease Models, Animal; Gerbillinae; Hippocampus | 1996 |
Propofol neuroprotection in a rat model of ischaemia reperfusion injury.
Topics: Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Antioxidants; Brain; Brain I | 1997 |
Temporary occlusion of the middle cerebral artery in intracranial aneurysm surgery: time limitation and advantage of brain protection.
Topics: Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Aneurysm, Ruptured; Brai | 1997 |
Propofol and hyperventilation for the treatment of increased intracranial pressure in rabbits.
Topics: Anesthesia; Anesthetics, General; Animals; Brain Ischemia; Evoked Potentials, Somatosensory; Intracr | 1998 |
Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Baclofen; Brain Ischemia; Dose-Response Relationship, Drug; GABA | 1999 |
Effects of graded suppression of the EEG with propofol on the neurological outcome following incomplete cerebral ischaemia in rats.
Topics: Anesthetics, Intravenous; Animals; Brain Ischemia; Dose-Response Relationship, Drug; Electroencephal | 1999 |
[Depressive effects of propofol on apoptotic injury and delayed neuronal death after forebrain ischemia in the rat--comparison with nitrous oxide-oxygen-isoflurane].
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2000 |
Effectiveness of propofol pretreatment on the extent of deranged cerebral mitochondrial oxidative enzyme system after incomplete forebrain ischemia/reperfusion in rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Free Radical Scavengers; Mitoc | 2000 |
The effects of thiopental and propofol on cell swelling induced by oxygen/glucose deprivation in the CA1 pyramidal cell layer of rat hippocampal slices.
Topics: Animals; Brain; Brain Ischemia; Glucose; Hippocampus; Male; Oxygen; Propofol; Rats; Rats, Wistar; Re | 2002 |
Neuroprotective effects of propofol following global cerebral ischemia in rats.
Topics: Anesthetics, Intravenous; Animals; Brain Ischemia; Lipid Peroxides; Male; Malondialdehyde; Neuroprot | 2002 |
Effects of propofol on lactate accumulation and oedema formation in focal cerebral ischaemia in hyperglycaemic rats.
Topics: Anesthetics, Intravenous; Animals; Brain; Brain Edema; Brain Ischemia; Hyperglycemia; Lactic Acid; M | 2002 |
Total intravenous anesthesia for improvement of intraoperative monitoring of somatosensory evoked potentials during aneurysm surgery.
Topics: Alfentanil; Anesthesia, Intravenous; Brain Ischemia; Electric Stimulation; Evoked Potentials, Somato | 1992 |
Comparative effects of propofol and halothane on outcome from temporary middle cerebral artery occlusion in the rat.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Blood Pressure; Brain; Brain Ischemia; Hal | 1992 |
The effects of propofol on brain electrical activity, neurologic outcome, and neuronal damage following incomplete ischemia in rats.
Topics: Animals; Brain; Brain Damage, Chronic; Brain Diseases; Brain Ischemia; Depression, Chemical; Electro | 1992 |