propofol has been researched along with Cerebral Infarction in 8 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been suggested that propofol has the protective effect on cerebral ischemia-reperfusion injury." | 7.70 | Effectiveness of propofol pretreatment on the extent of deranged cerebral mitochondrial oxidative enzyme system after incomplete forebrain ischemia/reperfusion in rats. ( Chung, C; Lee, Y; Oh, YS, 2000) |
| "Propofol has been shown to attenuate ischemic brain damage via inhibiting neuronal apoptosis." | 5.40 | Propofol reduces inflammatory reaction and ischemic brain damage in cerebral ischemia in rats. ( Chen, JP; Chen, Y; Shi, SS; Tu, XK; Yang, WZ, 2014) |
| "It has been suggested that propofol has the protective effect on cerebral ischemia-reperfusion injury." | 3.70 | Effectiveness of propofol pretreatment on the extent of deranged cerebral mitochondrial oxidative enzyme system after incomplete forebrain ischemia/reperfusion in rats. ( Chung, C; Lee, Y; Oh, YS, 2000) |
| "As propofol has been reported to have effects similar to those of thiopentone on cerebral blood flow, intracranial pressure and cerebral metabolic rate, we postulated that it might also have a protective effect on focal cerebral ischemia." | 3.69 | Propofol does not reduce infarct volume in rats undergoing permanent middle cerebral artery occlusion. ( Chang, CL; Cheng, JT; Huang, SJ; Lai, YY; Tsai, YC, 1994) |
| "Propofol has been shown to attenuate ischemic brain damage via inhibiting neuronal apoptosis." | 1.40 | Propofol reduces inflammatory reaction and ischemic brain damage in cerebral ischemia in rats. ( Chen, JP; Chen, Y; Shi, SS; Tu, XK; Yang, WZ, 2014) |
| "Propofol has not been studied directly in animals subject to cerebral ischemia in the conscious state." | 1.31 | Propofol anesthesia compared to awake reduces infarct size in rats. ( Bayona, NA; Cechetto, DF; Gelb, AW; Wilson, JX, 2002) |
| "Total cerebral infarct volumes (median +/- quartile deviation) were similar for the two groups (pentobarbital = 190 +/- 36 mm3; propofol = 200 +/- 24 mm3, P = 0." | 1.30 | Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal ischemia in the rat. ( Brinkhous, A; Dexter, F; Pearlstein, R; Pittman, JE; Sheng, H; Warner, DS, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (62.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, SS | 1 |
| Yang, WZ | 1 |
| Chen, Y | 1 |
| Chen, JP | 1 |
| Tu, XK | 1 |
| Tsai, YC | 1 |
| Huang, SJ | 1 |
| Lai, YY | 1 |
| Chang, CL | 1 |
| Cheng, JT | 1 |
| Cochran, D | 1 |
| Price, W | 1 |
| Gwinnutt, CL | 1 |
| Pittman, JE | 1 |
| Sheng, H | 1 |
| Pearlstein, R | 1 |
| Brinkhous, A | 1 |
| Dexter, F | 1 |
| Warner, DS | 1 |
| Lavine, SD | 1 |
| Masri, LS | 1 |
| Levy, ML | 1 |
| Giannotta, SL | 1 |
| Tommasino, C | 1 |
| Lee, Y | 1 |
| Chung, C | 1 |
| Oh, YS | 1 |
| Gelb, AW | 1 |
| Bayona, NA | 1 |
| Wilson, JX | 1 |
| Cechetto, DF | 1 |
8 other studies available for propofol and Cerebral Infarction
| Article | Year |
|---|---|
Propofol reduces inflammatory reaction and ischemic brain damage in cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Cyclooxygenase 2; Infarction, Middle Cerebral Artery; | 2014 |
Propofol does not reduce infarct volume in rats undergoing permanent middle cerebral artery occlusion.
Topics: Animals; Brain Ischemia; Cerebral Arteries; Cerebral Infarction; Constriction; Male; Propofol; Rats; | 1994 |
Unilateral convulsion after induction of anaesthesia with propofol.
Topics: Adult; Anesthetics, Intravenous; Cerebral Infarction; Humans; Male; Propofol; Seizures; Tomography, | 1996 |
Comparison of the effects of propofol and pentobarbital on neurologic outcome and cerebral infarct size after temporary focal ischemia in the rat.
Topics: Anesthetics, Intravenous; Animals; Brain; Cerebral Infarction; Electroencephalography; Ischemic Atta | 1997 |
Temporary occlusion of the middle cerebral artery in intracranial aneurysm surgery: time limitation and advantage of brain protection.
Topics: Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Aneurysm, Ruptured; Brai | 1997 |
Is lack of statistical power always evidence of lack of effect?
Topics: Anesthetics; Animals; Brain; Cerebral Infarction; Ischemic Attack, Transient; Pentobarbital; Propofo | 1998 |
Effectiveness of propofol pretreatment on the extent of deranged cerebral mitochondrial oxidative enzyme system after incomplete forebrain ischemia/reperfusion in rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Free Radical Scavengers; Mitoc | 2000 |
Propofol anesthesia compared to awake reduces infarct size in rats.
Topics: Anesthetics, Intravenous; Animals; Body Temperature; Brain; Cerebral Infarction; Cerebrovascular Cir | 2002 |