propofol has been researched along with Cerebral Infarction, Middle Cerebral Artery in 24 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propofol (PPF) is reported to play a protective role in ischemia/reperfusion (I/R) injury, including cerebral ischemia-reperfusion injury (CIRI)." | 8.02 | Propofol Downregulates lncRNA MALAT1 to Alleviate Cerebral Ischemia-Reperfusion Injury. ( Chen, J; Cheng, S; Hu, Y; Ye, C, 2021) |
| "It has been shown in our previous study that propofol postconditioning enhanced the activity of phosphatidylinositol-3-kinase (PI3K) and prevented the internalization of GluR2 subunit of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thus provided neuroprotection in cerebral ischemia/reperfusion (I/R) injury." | 7.81 | The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats. ( Liu, S; Wang, G; Wang, H; Zhu, A, 2015) |
| "To investigate the protective effect of propofol against focal cerebral ischemia/reperfusion (I/R) injury in rats and its relation with gap junction." | 7.81 | [Protective effect of propofol against cerebral ischemic/reperfusion injury may involve inhibition of gap junction]. ( Chen, Y; Dong, S; Fan, Z; Li, Y; Liu, H; Tong, X; Yu, L, 2015) |
| "To investigate the protective effects of propofol in brain ischemia/reperfusion injury and the role of heme oxygenase-1 (HO-1) in this process." | 7.79 | Propofol attenuates cerebral ischemia/reperfusion injury partially using heme oxygenase-1. ( Cang, J; Liang, C; Wang, H; Xue, Z, 2013) |
| "Propofol (2,6-diisopropylphenol) has been shown to attenuate neuronal injury in a number of experimental conditions, but studies in models of cerebral ischemia have yielded conflicting results." | 7.73 | Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism. ( Adembri, C; Chiarugi, A; Cozzi, A; De Gaudio, RA; Gramigni, E; Pancani, T; Pellegrini-Giampietro, DE; Tani, A; Venturi, L, 2006) |
| "To compare the effects of pentobarbital and propofol on the outcome of focal cerebral ischemia model, and to evaluate the availability of propofol in setting the focal cerebral ischemia." | 7.72 | [Comparison of pentobarbital and propofol on the outcome of focal cerebral ischemia model in rats]. ( Kang, QY; Li, J; Liu, Y; Zhang, PB; Zhao, JJ, 2004) |
| "Propofol has been shown to attenuate ischemic brain damage via inhibiting neuronal apoptosis." | 5.40 | Propofol reduces inflammatory reaction and ischemic brain damage in cerebral ischemia in rats. ( Chen, JP; Chen, Y; Shi, SS; Tu, XK; Yang, WZ, 2014) |
| "Propofol treatment reduced infarct volume and improved the neurological functions." | 5.39 | Propofol protects against focal cerebral ischemia via inhibition of microglia-mediated proinflammatory cytokines in a rat model of experimental stroke. ( Liu, F; Tan, Y; Tang, X; Wu, X; Yang, Z; Zhou, R, 2013) |
| "Rats underwent 2 h of middle cerebral artery occlusion (MCAO) followed by 22 h of reperfusion were randomly divided into nine groups (n=15 each): sham-operated group, MCAO group, propofol 10, 20 and 35 mg x kg(-1) x h(-1) group (propofol 10, 20, 35 mg x kg(-1) x h(-1) infused at the onset of reperfusion for 30 min), wortmannin group (wortmannin 0." | 5.35 | The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats. ( Wang, GL; Wang, HY; Wang, Y; Yu, YH, 2009) |
| "Propofol (PPF) is reported to play a protective role in ischemia/reperfusion (I/R) injury, including cerebral ischemia-reperfusion injury (CIRI)." | 4.02 | Propofol Downregulates lncRNA MALAT1 to Alleviate Cerebral Ischemia-Reperfusion Injury. ( Chen, J; Cheng, S; Hu, Y; Ye, C, 2021) |
| "It has been shown in our previous study that propofol postconditioning enhanced the activity of phosphatidylinositol-3-kinase (PI3K) and prevented the internalization of GluR2 subunit of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thus provided neuroprotection in cerebral ischemia/reperfusion (I/R) injury." | 3.81 | The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats. ( Liu, S; Wang, G; Wang, H; Zhu, A, 2015) |
| "To investigate the protective effect of propofol against focal cerebral ischemia/reperfusion (I/R) injury in rats and its relation with gap junction." | 3.81 | [Protective effect of propofol against cerebral ischemic/reperfusion injury may involve inhibition of gap junction]. ( Chen, Y; Dong, S; Fan, Z; Li, Y; Liu, H; Tong, X; Yu, L, 2015) |
| "To investigate the protective effects of propofol in brain ischemia/reperfusion injury and the role of heme oxygenase-1 (HO-1) in this process." | 3.79 | Propofol attenuates cerebral ischemia/reperfusion injury partially using heme oxygenase-1. ( Cang, J; Liang, C; Wang, H; Xue, Z, 2013) |
| "Propofol (2,6-diisopropylphenol) has been shown to attenuate neuronal injury in a number of experimental conditions, but studies in models of cerebral ischemia have yielded conflicting results." | 3.73 | Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism. ( Adembri, C; Chiarugi, A; Cozzi, A; De Gaudio, RA; Gramigni, E; Pancani, T; Pellegrini-Giampietro, DE; Tani, A; Venturi, L, 2006) |
| "To compare the effects of pentobarbital and propofol on the outcome of focal cerebral ischemia model, and to evaluate the availability of propofol in setting the focal cerebral ischemia." | 3.72 | [Comparison of pentobarbital and propofol on the outcome of focal cerebral ischemia model in rats]. ( Kang, QY; Li, J; Liu, Y; Zhang, PB; Zhao, JJ, 2004) |
| "It has been recognized to be critical in cerebral ischemia-reperfusion injury, and reactive oxygen species (ROS) can induce parthanatos." | 1.48 | Propofol inhibits parthanatos via ROS-ER-calcium-mitochondria signal pathway in vivo and vitro. ( Chen, Y; Hu, J; Liu, Y; Liu, Z; Pang, Q; Song, R; Tang, J; Zhong, H; Zhuang, J, 2018) |
| "Propofol has been shown to attenuate ischemic brain damage via inhibiting neuronal apoptosis." | 1.40 | Propofol reduces inflammatory reaction and ischemic brain damage in cerebral ischemia in rats. ( Chen, JP; Chen, Y; Shi, SS; Tu, XK; Yang, WZ, 2014) |
| "I/R insult was induced by 2 h middle cerebral artery occlusion (MCAO) followed by 24 h reperfusion; Drugs were administered 20 min before the onset of ischemia and continued for another 2 h." | 1.40 | Effects of propofol-dexmedetomidine combination on ischemia reperfusion-induced cerebral injury. ( Du, H; He, Y; Kou, D; Li, Z; Wang, Z; Yu, W, 2014) |
| "Propofol post-treatment significantly reduced cerebral edema (P < 0." | 1.39 | Effect of propofol post-treatment on blood-brain barrier integrity and cerebral edema after transient cerebral ischemia in rats. ( Cui, HS; Kim, JM; Kim, SY; Koo, BN; Lee, JE; Lee, JH; Shin, SK, 2013) |
| "Propofol treatment reduced infarct volume and improved the neurological functions." | 1.39 | Propofol protects against focal cerebral ischemia via inhibition of microglia-mediated proinflammatory cytokines in a rat model of experimental stroke. ( Liu, F; Tan, Y; Tang, X; Wu, X; Yang, Z; Zhou, R, 2013) |
| "Propofol post-treatment also attenuated brain water content at 24 and 72 h and reduced neurologic deficit score at 72 h and 7 days of reperfusion (all P < 0." | 1.39 | Propofol increases expression of basic fibroblast growth factor after transient cerebral ischemia in rats. ( An, P; Chen, WM; Jiang, C; Tong, DY; Wang, J; Zhang, LM; Zhao, P; Zhao, XC, 2013) |
| "Rats underwent 2 h of middle cerebral artery occlusion (MCAO) followed by 22 h of reperfusion were randomly divided into nine groups (n=15 each): sham-operated group, MCAO group, propofol 10, 20 and 35 mg x kg(-1) x h(-1) group (propofol 10, 20, 35 mg x kg(-1) x h(-1) infused at the onset of reperfusion for 30 min), wortmannin group (wortmannin 0." | 1.35 | The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats. ( Wang, GL; Wang, HY; Wang, Y; Yu, YH, 2009) |
| "When propofol EDTA was given intravenously 10 mins before cerebral ischemia, the zinc concentration decreased significantly in the cortical area, but not in the subcortex." | 1.35 | Propofol exerts greater neuroprotection with disodium edetate than without it. ( Hara, H; Hasegawa, T; Iwama, T; Kotani, Y; Nagase, H; Nakajima, Y; Satoh, M; Shimazawa, M; Yoshimura, S, 2008) |
| "The use of pharmacologic coma (PC) to treat status epilepticus (SE) is not always successful, and there are no guidelines for the duration of PC in an attempt to achieve seizure control." | 1.32 | Now we lay them down to sleep: ethical issues with the use of pharmacologic coma for adult status epilepticus. ( Bramstedt, KA; Morris, HH; Tanner, A, 2004) |
| "Propofol was intravenously infused in eight rats during ischemia (60 min) and reperfusion (60 min) at an average dose of 36 mg/kg/h." | 1.31 | Propofol reduces infarct size and striatal dopamine accumulation following transient middle cerebral artery occlusion: a microdialysis study. ( Bosco, G; Camporesi, CV; Camporesi, EM; Chen, C; Wang, J; Yang, X; Yang, Z, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (33.33) | 29.6817 |
| 2010's | 14 (58.33) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, B | 1 |
| Ou, H | 1 |
| Ren, F | 1 |
| Guan, Y | 1 |
| Huan, Y | 1 |
| Cai, H | 1 |
| Hu, Y | 1 |
| Ye, C | 1 |
| Cheng, S | 1 |
| Chen, J | 2 |
| Zheng, Y | 1 |
| Bu, J | 1 |
| Yu, L | 2 |
| Liu, H | 2 |
| Zhong, H | 1 |
| Song, R | 1 |
| Pang, Q | 1 |
| Liu, Y | 3 |
| Zhuang, J | 1 |
| Chen, Y | 3 |
| Hu, J | 2 |
| Liu, Z | 1 |
| Tang, J | 1 |
| Yu, H | 1 |
| Wang, X | 1 |
| Kang, F | 1 |
| Chen, Z | 1 |
| Meng, Y | 1 |
| Dai, M | 1 |
| Liang, C | 1 |
| Cang, J | 1 |
| Wang, H | 4 |
| Xue, Z | 1 |
| Lee, JH | 1 |
| Cui, HS | 1 |
| Shin, SK | 1 |
| Kim, JM | 1 |
| Kim, SY | 1 |
| Lee, JE | 1 |
| Koo, BN | 1 |
| Takagaki, M | 1 |
| Feuerstein, D | 1 |
| Kumagai, T | 1 |
| Gramer, M | 1 |
| Yoshimine, T | 1 |
| Graf, R | 1 |
| Zhou, R | 1 |
| Yang, Z | 2 |
| Tang, X | 1 |
| Tan, Y | 1 |
| Wu, X | 1 |
| Liu, F | 1 |
| Shi, SS | 1 |
| Yang, WZ | 1 |
| Chen, JP | 1 |
| Tu, XK | 1 |
| Wang, Z | 1 |
| Kou, D | 1 |
| Li, Z | 1 |
| He, Y | 1 |
| Yu, W | 1 |
| Du, H | 1 |
| Liu, S | 1 |
| Wang, G | 2 |
| Zhu, A | 1 |
| Arbour, RB | 1 |
| Dissin, J | 1 |
| Fan, Z | 1 |
| Tong, X | 1 |
| Li, Y | 1 |
| Dong, S | 1 |
| Wang, HY | 1 |
| Wang, GL | 1 |
| Yu, YH | 1 |
| Wang, Y | 1 |
| Luo, M | 1 |
| Li, C | 1 |
| Zhao, XC | 1 |
| Zhang, LM | 1 |
| Tong, DY | 1 |
| An, P | 1 |
| Jiang, C | 1 |
| Zhao, P | 1 |
| Chen, WM | 1 |
| Wang, J | 2 |
| Yang, X | 1 |
| Camporesi, CV | 1 |
| Bosco, G | 1 |
| Chen, C | 1 |
| Camporesi, EM | 1 |
| Bramstedt, KA | 1 |
| Morris, HH | 1 |
| Tanner, A | 1 |
| Zhang, PB | 1 |
| Li, J | 1 |
| Zhao, JJ | 1 |
| Kang, QY | 1 |
| Adembri, C | 1 |
| Venturi, L | 1 |
| Tani, A | 1 |
| Chiarugi, A | 1 |
| Gramigni, E | 1 |
| Cozzi, A | 1 |
| Pancani, T | 1 |
| De Gaudio, RA | 1 |
| Pellegrini-Giampietro, DE | 1 |
| Fernández Sánchez, LJ | 1 |
| Pérez González, R | 1 |
| Guasch Arévalo, E | 1 |
| Martín Reyes, R | 1 |
| Gilsanz Rodríguez, F | 1 |
| Kotani, Y | 1 |
| Nakajima, Y | 1 |
| Hasegawa, T | 1 |
| Satoh, M | 1 |
| Nagase, H | 1 |
| Shimazawa, M | 1 |
| Yoshimura, S | 1 |
| Iwama, T | 1 |
| Hara, H | 1 |
| Bhardwaj, A | 1 |
| Castro III, AF | 1 |
| Alkayed, NJ | 1 |
| Hurn, PD | 1 |
| Kirsch, JR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Narcotrend Depth of Anaesthesia Monitor as an Indicator of Seizures and Burst Suppression in the Intensive Care Unit[NCT06067750] | 106 participants (Anticipated) | Observational | 2023-06-27 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
24 other studies available for propofol and Cerebral Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
Propofol Protects against Cerebral Ischemia/Reperfusion Injury by Down-Regulating Long Noncoding RNA SNHG14.
Topics: Animals; Apoptosis; Brain Ischemia; Glucose; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred | 2021 |
Propofol Downregulates lncRNA MALAT1 to Alleviate Cerebral Ischemia-Reperfusion Injury.
Topics: Animals; Apoptosis; Brain; Disease Models, Animal; Down-Regulation; Infarction, Middle Cerebral Arte | 2021 |
Nobiletin improves propofol-induced neuroprotection via regulating Akt/mTOR and TLR 4/NF-κB signaling in ischemic brain injury in rats.
Topics: Animals; Apoptosis; Behavior, Animal; Brain Ischemia; Cytokines; Flavones; Infarction, Middle Cerebr | 2017 |
Propofol inhibits parthanatos via ROS-ER-calcium-mitochondria signal pathway in vivo and vitro.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Brain Ischemia; Calcium; Cell Death; Cell Line; | 2018 |
Propofol attenuates inflammatory damage on neurons following cerebral infarction by inhibiting excessive activation of microglia.
Topics: Actins; Animals; Brain Infarction; Cell Death; Cell Movement; Cell Proliferation; Cytoskeleton; Dise | 2019 |
Propofol attenuates cerebral ischemia/reperfusion injury partially using heme oxygenase-1.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Biomarkers; Blotting, Western; Brain Ischemia; Heme Ox | 2013 |
Effect of propofol post-treatment on blood-brain barrier integrity and cerebral edema after transient cerebral ischemia in rats.
Topics: Animals; Aquaporin 1; Aquaporin 4; Blood-Brain Barrier; Brain Edema; Hypoxia-Inducible Factor 1, alp | 2013 |
Isoflurane suppresses cortical spreading depolarizations compared to propofol--implications for sedation of neurocritical care patients.
Topics: Animals; Cerebrovascular Circulation; Cortical Spreading Depression; Disease Models, Animal; Dose-Re | 2014 |
Propofol protects against focal cerebral ischemia via inhibition of microglia-mediated proinflammatory cytokines in a rat model of experimental stroke.
Topics: Animals; Biomarkers; Brain Ischemia; Cytokines; Disease Models, Animal; Gene Expression; Infarction, | 2013 |
Propofol reduces inflammatory reaction and ischemic brain damage in cerebral ischemia in rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Cyclooxygenase 2; Infarction, Middle Cerebral Artery; | 2014 |
Effects of propofol-dexmedetomidine combination on ischemia reperfusion-induced cerebral injury.
Topics: Animals; Dexmedetomidine; Drug Therapy, Combination; Infarction, Middle Cerebral Artery; Male; Propo | 2014 |
The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats.
Topics: Acute Disease; Animals; Brain Ischemia; CA1 Region, Hippocampal; Carboxylic Acids; Cell Survival; Di | 2015 |
Predictive value of the bispectral index for burst suppression on diagnostic electroencephalogram during drug-induced coma.
Topics: Adult; Alcohol Withdrawal Seizures; Cerebral Cortex; Cohort Studies; Consciousness Monitors; Deep Se | 2015 |
[Protective effect of propofol against cerebral ischemic/reperfusion injury may involve inhibition of gap junction].
Topics: Animals; bcl-2-Associated X Protein; Brain; Brain Ischemia; Connexin 43; Gap Junctions; Infarction, | 2015 |
The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats.
Topics: Androstadienes; Animals; Brain; Brain Infarction; Disease Models, Animal; Dose-Response Relationship | 2009 |
Propofol post-conditioning induced long-term neuroprotection and reduced internalization of AMPAR GluR2 subunit in a rat model of focal cerebral ischemia/reperfusion.
Topics: Anesthetics, Intravenous; Animals; Antimetabolites; Behavior, Animal; Blotting, Western; Brain Ische | 2011 |
Propofol increases expression of basic fibroblast growth factor after transient cerebral ischemia in rats.
Topics: Animals; Fibroblast Growth Factor 2; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; | 2013 |
Propofol reduces infarct size and striatal dopamine accumulation following transient middle cerebral artery occlusion: a microdialysis study.
Topics: Animals; Corpus Striatum; Dopamine; Infarction, Middle Cerebral Artery; Male; Microdialysis; Propofo | 2002 |
Now we lay them down to sleep: ethical issues with the use of pharmacologic coma for adult status epilepticus.
Topics: Adult; Anticonvulsants; Brain; Brain Edema; Coma; Drug Therapy; Fatal Outcome; Female; Humans; Hypno | 2004 |
[Comparison of pentobarbital and propofol on the outcome of focal cerebral ischemia model in rats].
Topics: Adjuvants, Anesthesia; Anesthetics, Intravenous; Animals; Brain Ischemia; Disease Models, Animal; In | 2004 |
Neuroprotective effects of propofol in models of cerebral ischemia: inhibition of mitochondrial swelling as a possible mechanism.
Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Brain Ischemia; Calcium; Glucose; Hippocampus; | 2006 |
[Perioperative treatment of a pregnant woman with recent cerebral infarction secondary to noncompaction cardiomyopathy].
Topics: Adrenergic beta-Antagonists; Androstanols; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, | 2006 |
Propofol exerts greater neuroprotection with disodium edetate than without it.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Benzimidazoles; Brain Ischemia; Cell Count; Cell Survi | 2008 |
Anesthetic choice of halothane versus propofol: impact on experimental perioperative stroke.
Topics: Administration, Inhalation; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intrav | 2001 |