propofol has been researched along with Brain Injuries in 81 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propofol infusion syndrome (PRIS) is defined as acute bradycardia progressing to asystole combined with lipemic plasma, fatty liver enlargement, metabolic acidosis with negative base excess >10 mmol l(-1), rhabdomyolysis or myoglobinuria associated with propofol infusion." | 8.85 | Propofol infusion syndrome: update of clinical manifestation and pathophysiology. ( Bein, B; Fudickar, A, 2009) |
| "The propofol infusion syndrome is a rare condition characterized by the occurrence of lactic acidosis, rhabdomyolysis and cardiovascular collapse following high-dose propofol infusion over prolonged periods of time." | 8.84 | Update on the propofol infusion syndrome in ICU management of patients with head injury. ( Cremer, OL; Kalkman, CJ; Otterspoor, LC, 2008) |
| "Propofol infusion syndrome (PRIS) is well known, often associated with, lethal complication of sedation with propofol." | 7.78 | Propofol infusion syndrome heralded by ECG changes. ( Aslan, A; Jacobs, B; Mijzen, EJ; Rodgers, MG, 2012) |
| "To investigate the effects of propofol on the three kinds of brain injuries induced by metabolic disorder, neurotoxicity of excitatory amino acid, and oxygen-derived free radicals in rat cerebral cortical and hippocampal slices." | 7.72 | [The influences of propofol on different kinds of brain injuries in rat brain slices]. ( Chen, HZ; Wang, ZJ; Xia, M; Xue, QS; Yu, BW, 2003) |
| "Remifentanil was effective, well tolerated and provided comparable haemodynamic stability to that of the hypnotic-based regimen." | 6.71 | Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308]. ( Karabinis, A; Kirkham, AJ; Komnos, A; Mandragos, K; Soukup, J; Speelberg, B; Stergiopoulos, S, 2004) |
| "Propofol is a potent and widely used central-acting sedative drug." | 5.35 | Propofol infusion syndrome with arrhythmia, myocardial fat accumulation and cardiac failure. ( Jorens, PG; Van den Eynden, GG, 2009) |
| "Propofol infusion syndrome is a rare but frequently fatal complication in critically ill children who are given prolonged high-dose infusions of the drug." | 5.34 | Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injury. ( Coritsidis, G; Rehman, Z; Sabsovich, I; Yunen, J, 2007) |
| "Propofol infusion syndrome (PRIS) is defined as acute bradycardia progressing to asystole combined with lipemic plasma, fatty liver enlargement, metabolic acidosis with negative base excess >10 mmol l(-1), rhabdomyolysis or myoglobinuria associated with propofol infusion." | 4.85 | Propofol infusion syndrome: update of clinical manifestation and pathophysiology. ( Bein, B; Fudickar, A, 2009) |
| "The propofol infusion syndrome is a rare condition characterized by the occurrence of lactic acidosis, rhabdomyolysis and cardiovascular collapse following high-dose propofol infusion over prolonged periods of time." | 4.84 | Update on the propofol infusion syndrome in ICU management of patients with head injury. ( Cremer, OL; Kalkman, CJ; Otterspoor, LC, 2008) |
| "Since, in healthy individuals, slow waves can be induced with anesthetics, the authors tested the possible association between hypoxic brain injury and slow-wave activity in comatose postcardiac arrest patients (n = 10) using controlled propofol exposure." | 3.85 | Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury. ( Ala-Kokko, T; Alahuhta, S; Backman, JT; Huuskonen, U; Kortelainen, J; Koskenkari, J; Laurila, J; Seppänen, T; Väyrynen, E, 2017) |
| "Propofol infusion syndrome (PRIS) is well known, often associated with, lethal complication of sedation with propofol." | 3.78 | Propofol infusion syndrome heralded by ECG changes. ( Aslan, A; Jacobs, B; Mijzen, EJ; Rodgers, MG, 2012) |
| "To evaluate the effects of the neurological "wake-up test" (NWT), defined as interruption of continuous propofol sedation and evaluation of the patient's level of consciousness, on intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in patients with severe subarachnoid hemorrhage (SAH) or traumatic brain injury (TBI)." | 3.75 | Effects of the neurological wake-up test on intracranial pressure and cerebral perfusion pressure in brain-injured patients. ( Enblad, P; Marklund, N; Skoglund, K, 2009) |
| "To investigate the effects of propofol on the three kinds of brain injuries induced by metabolic disorder, neurotoxicity of excitatory amino acid, and oxygen-derived free radicals in rat cerebral cortical and hippocampal slices." | 3.72 | [The influences of propofol on different kinds of brain injuries in rat brain slices]. ( Chen, HZ; Wang, ZJ; Xia, M; Xue, QS; Yu, BW, 2003) |
| " Propofol was used for surgical anesthesia because recovery in normal animals from an intravenous infusion was found to be nearly complete within 2 h of cessation and absolutely complete by 4 h." | 3.68 | Early assessment of neurologic deficits in the fluid percussion model of brain injury. ( Einhaus, SL; Hilton, DL; Meric, AL; Park, MR; Robertson, JT; Schweitzer, JB; White, RP, 1993) |
| " Both sedatives were administered over 7 days and individual dosage was adapted according to clinical requirements." | 2.72 | Effects of propofol vs methohexital on neutrophil function and immune status in critically ill patients. ( Hout, Nv; Huettemann, E; Jung, A; Sakka, SG; Vogelsang, H, 2006) |
| "Remifentanil was effective, well tolerated and provided comparable haemodynamic stability to that of the hypnotic-based regimen." | 2.71 | Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308]. ( Karabinis, A; Kirkham, AJ; Komnos, A; Mandragos, K; Soukup, J; Speelberg, B; Stergiopoulos, S, 2004) |
| "Traumatic brain injuries remain an area of great challenge to both neurosurgeons and neuroanaesthesiologists." | 2.45 | Traumatic brain injury: neuroprotective anaesthetic techniques, an update. ( Aal-Shaya, WA; Al-Faridi, K; Halawani, MM; Taha, WS; Tawfeeq, NA, 2009) |
| "Propofol has been shown to ameliorate neuroinflammatory injury, but the exact mechanism of its neuroprotective role remains to be fully elucidated." | 1.56 | Propofol Attenuates Inflammatory Damage via Inhibiting NLRP1-Casp1-Casp6 Signaling in Ischemic Brain Injury. ( Chen, P; Li, K; Li, X; Ma, Z; Pan, J; Zhao, G, 2020) |
| "Propofol toxicity was abolished both by pharmacologic inhibition of the cell death domain of the p75 neurotrophin receptor (TAT-Pep5) and in mice lacking the extracellular neurotrophin binding site of p75 neurotrophin receptor." | 1.43 | Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro-Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult Mice. ( Ditter, A; Engelhard, K; Gölz, C; Granold, M; Luh, C; Moosmann, B; Pöttker, B; Radyushkin, K; Schäfer, MK; Schaible, EV; Sebastiani, A; Sebastiani, P; Thal, SC; Timaru-Kast, R; Werner, C, 2016) |
| "The propofol infusion rate was non-significantly lower with drainage." | 1.38 | Effect of continuous cerebrospinal fluid drainage on therapeutic intensity in severe traumatic brain injury. ( Boch, AL; Boroli, F; Chauvet, D; Lescot, T; Puybasset, L; Reina, V, 2012) |
| "Propofol infusion was stopped immediately after the first signs of biochemical derangement." | 1.35 | Monitoring biochemical parameters as an early sign of propofol infusion syndrome: false feeling of security. ( Hartman, BJ; van Gestel, JP; Veldhoen, ES, 2009) |
| "Propofol is a potent and widely used central-acting sedative drug." | 1.35 | Propofol infusion syndrome with arrhythmia, myocardial fat accumulation and cardiac failure. ( Jorens, PG; Van den Eynden, GG, 2009) |
| "Propofol infusion syndrome is a rare but frequently fatal complication in critically ill children who are given prolonged high-dose infusions of the drug." | 1.34 | Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injury. ( Coritsidis, G; Rehman, Z; Sabsovich, I; Yunen, J, 2007) |
| "Propofol has the protective effect on the intestine following traumatic brain injury in rats." | 1.34 | Effect of propofol on mucous permeability and inflammatory mediators expression in the intestine following traumatic brain injury in rats. ( Qian, Y; Shen, J; Sun, J; Wang, L; Wang, Z, 2007) |
| "Rats treated with isoflurane had the best cognitive recovery (p < 0." | 1.33 | Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. ( Alexander, H; Clark, RS; Dixon, CE; Jenkins, L; Kochanek, PM; Statler, KD; Vagni, V, 2006) |
| "Halothane 2% did not increase the mortality in traumatized mice." | 1.31 | Influence of anesthesia protocol in experimental traumatic brain injury. ( Mesenge, H; Plotkine, M; Stutzmann, AM; Tecoult, E; Wahl, F, 2000) |
| "Propofol is an intravenous anaesthetic agent having anticonvulsant property." | 1.31 | [Efficacy of propofol in controlling myoclonus during rewarming in a brain hypothermia patient]. ( Machida, K; Mizuno, J; Sakai, K; Sugimoto, S; Tsutsui, T, 2002) |
| "3." | 1.29 | Neuroprotection by propofol in acute mechanical injury: role of GABAergic inhibition. ( Hollrigel, GS; Soltesz, I; Toth, K, 1996) |
| "Propofol was infused during 41." | 1.28 | Effects of propofol on cerebral hemodynamics and metabolism in patients with brain trauma. ( Chetanneau, A; Fauchoux, N; Lelausque, JN; Ménégalli, D; Pinaud, M; Souron, R, 1990) |
| "Propofol (Disoprivan) is a rapid and effective hypnotic comparable with etomidate." | 1.27 | [Intracranial pressure in patients with craniocerebral trauma after administration of propofol and thiopental]. ( Hartung, HJ, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (4.94) | 18.7374 |
| 1990's | 12 (14.81) | 18.2507 |
| 2000's | 32 (39.51) | 29.6817 |
| 2010's | 28 (34.57) | 24.3611 |
| 2020's | 5 (6.17) | 2.80 |
| Authors | Studies |
|---|---|
| Duclos, C | 1 |
| Maschke, C | 1 |
| Mahdid, Y | 1 |
| Nadin, D | 1 |
| Rokos, A | 1 |
| Arbour, C | 1 |
| Badawy, M | 1 |
| Létourneau, J | 1 |
| Owen, AM | 1 |
| Plourde, G | 1 |
| Blain-Moraes, S | 1 |
| Jeffcote, T | 1 |
| Weir, T | 1 |
| Anstey, J | 1 |
| Mcnamara, R | 1 |
| Bellomo, R | 1 |
| Udy, A | 1 |
| Chang, J | 1 |
| Yan, X | 1 |
| Zeng, Y | 1 |
| Klein, SP | 1 |
| Fieuws, S | 1 |
| Meyfroidt, G | 1 |
| Depreitere, B | 1 |
| Ma, Z | 1 |
| Li, K | 1 |
| Chen, P | 1 |
| Pan, J | 1 |
| Li, X | 1 |
| Zhao, G | 1 |
| Sanz-García, A | 1 |
| Pérez-Romero, M | 1 |
| Pastor, J | 1 |
| Sola, RG | 1 |
| Vega-Zelaya, L | 1 |
| Vega, G | 1 |
| Monasterio, F | 1 |
| Torrecilla, C | 1 |
| Pulido, P | 1 |
| Ortega, GJ | 1 |
| Guan, R | 1 |
| Lv, J | 1 |
| Xiao, F | 1 |
| Tu, Y | 1 |
| Xie, Y | 1 |
| Li, L | 1 |
| Ding, Z | 1 |
| Zhang, J | 2 |
| Xu, J | 1 |
| Sheng, G | 1 |
| Huang, G | 1 |
| Hao, J | 1 |
| Luo, JS | 1 |
| Weng, Q | 1 |
| He, Y | 1 |
| Liu, J | 1 |
| Yang, MH | 1 |
| Bian, GY | 1 |
| Liu, T | 1 |
| Sanders, RD | 2 |
| Coburn, M | 3 |
| Pandharipande, PP | 2 |
| Luo, T | 1 |
| Wu, J | 1 |
| Kabadi, SV | 1 |
| Sabirzhanov, B | 1 |
| Guanciale, K | 1 |
| Hanscom, M | 1 |
| Faden, J | 1 |
| Cardiff, K | 1 |
| Bengson, CJ | 1 |
| Faden, AI | 1 |
| Thal, SC | 2 |
| Timaru-Kast, R | 2 |
| Wilde, F | 1 |
| Merk, P | 1 |
| Johnson, F | 1 |
| Frauenknecht, K | 1 |
| Sebastiani, A | 2 |
| Sommer, C | 1 |
| Staib-Lasarzik, I | 1 |
| Werner, C | 3 |
| Engelhard, K | 3 |
| Gu, JW | 1 |
| Yang, T | 1 |
| Kuang, YQ | 1 |
| Huang, HD | 1 |
| Kong, B | 1 |
| Shu, HF | 1 |
| Yu, SX | 1 |
| Zhang, JH | 1 |
| Colton, K | 2 |
| Yang, S | 2 |
| Hu, PF | 2 |
| Chen, HH | 2 |
| Bonds, B | 2 |
| Scalea, TM | 2 |
| Stein, DM | 2 |
| Stansbury, LG | 1 |
| Yu, Y | 1 |
| Jian, MY | 1 |
| Wang, YZ | 1 |
| Han, RQ | 1 |
| Yen, HC | 1 |
| Chen, TW | 1 |
| Yang, TC | 1 |
| Wei, HJ | 1 |
| Hsu, JC | 1 |
| Lin, CL | 1 |
| Granold, M | 1 |
| Ditter, A | 1 |
| Sebastiani, P | 1 |
| Gölz, C | 1 |
| Pöttker, B | 1 |
| Luh, C | 1 |
| Schaible, EV | 1 |
| Radyushkin, K | 1 |
| Schäfer, MK | 1 |
| Moosmann, B | 1 |
| Pakkianathan, C | 1 |
| Benggon, M | 1 |
| Khatibi, NH | 1 |
| Chen, H | 1 |
| Marcantonio, S | 1 |
| Applegate, R | 1 |
| Tang, J | 1 |
| Woldegerima, N | 1 |
| Rosenblatt, K | 1 |
| Mintz, CD | 1 |
| Mesa Suárez, P | 1 |
| Santotoribio, JD | 1 |
| Ramos Ramos, V | 1 |
| González García, MÁ | 1 |
| Pérez Ramos, S | 1 |
| Portilla Huertas, D | 1 |
| Muñoz Hoyos, A | 1 |
| Oddo, M | 1 |
| Crippa, IA | 1 |
| Mehta, S | 1 |
| Menon, D | 1 |
| Payen, JF | 1 |
| Taccone, FS | 1 |
| Citerio, G | 1 |
| Antkowiak, B | 1 |
| Rudolph, U | 1 |
| Kortelainen, J | 1 |
| Väyrynen, E | 1 |
| Huuskonen, U | 1 |
| Laurila, J | 1 |
| Koskenkari, J | 1 |
| Backman, JT | 1 |
| Alahuhta, S | 1 |
| Seppänen, T | 1 |
| Ala-Kokko, T | 1 |
| Kirsch, M | 1 |
| Guldenmund, P | 1 |
| Ali Bahri, M | 1 |
| Demertzi, A | 1 |
| Baquero, K | 1 |
| Heine, L | 1 |
| Charland-Verville, V | 1 |
| Vanhaudenhuyse, A | 1 |
| Bruno, MA | 1 |
| Gosseries, O | 1 |
| Di Perri, C | 1 |
| Ziegler, E | 1 |
| Brichant, JF | 1 |
| Soddu, A | 1 |
| Bonhomme, V | 1 |
| Laureys, S | 1 |
| Otterspoor, LC | 1 |
| Kalkman, CJ | 2 |
| Cremer, OL | 2 |
| Huang, SN | 1 |
| Liu, YT | 1 |
| Zhang, JX | 1 |
| Veldhoen, ES | 1 |
| Hartman, BJ | 1 |
| van Gestel, JP | 1 |
| Rossaint, J | 1 |
| Rossaint, R | 1 |
| Weis, J | 1 |
| Fries, M | 1 |
| Rex, S | 1 |
| Fudickar, A | 1 |
| Bein, B | 1 |
| Skoglund, K | 1 |
| Enblad, P | 1 |
| Marklund, N | 1 |
| Jorens, PG | 1 |
| Van den Eynden, GG | 1 |
| Tawfeeq, NA | 1 |
| Halawani, MM | 1 |
| Al-Faridi, K | 1 |
| Aal-Shaya, WA | 1 |
| Taha, WS | 1 |
| Klimathianaki, M | 1 |
| Kondili, E | 1 |
| Alexopoulou, C | 1 |
| Prinianakis, G | 1 |
| Georgopoulos, D | 1 |
| Yu, G | 1 |
| Dymond, M | 1 |
| Yuan, L | 1 |
| Chaturvedi, LS | 1 |
| Shiratsuchi, H | 1 |
| Durairaj, S | 1 |
| Marsh, HM | 1 |
| Basson, MD | 1 |
| Roberts, DJ | 1 |
| Hall, RI | 1 |
| Kramer, AH | 1 |
| Robertson, HL | 1 |
| Gallagher, CN | 1 |
| Zygun, DA | 1 |
| Tanguy, M | 1 |
| Seguin, P | 1 |
| Laviolle, B | 1 |
| Bleichner, JP | 1 |
| Morandi, X | 1 |
| Malledant, Y | 1 |
| Lescot, T | 1 |
| Boroli, F | 1 |
| Reina, V | 1 |
| Chauvet, D | 1 |
| Boch, AL | 1 |
| Puybasset, L | 1 |
| Mijzen, EJ | 1 |
| Jacobs, B | 1 |
| Aslan, A | 1 |
| Rodgers, MG | 1 |
| James, ML | 1 |
| Olson, DM | 1 |
| Graffagnino, C | 1 |
| Oertel, M | 1 |
| Kelly, DF | 1 |
| Lee, JH | 1 |
| Glenn, TC | 1 |
| Vespa, PM | 1 |
| Martin, NA | 1 |
| Rhoney, DH | 1 |
| Parker, D | 1 |
| Formea, CM | 1 |
| Yap, C | 1 |
| Coplin, WM | 1 |
| Adelson, PD | 1 |
| Bratton, SL | 1 |
| Carney, NA | 1 |
| Chesnut, RM | 1 |
| du Coudray, HE | 1 |
| Goldstein, B | 1 |
| Kochanek, PM | 2 |
| Miller, HC | 1 |
| Partington, MD | 1 |
| Selden, NR | 1 |
| Warden, CR | 1 |
| Wright, DW | 1 |
| Steiner, LA | 1 |
| Johnston, AJ | 1 |
| Chatfield, DA | 1 |
| Czosnyka, M | 1 |
| Coleman, MR | 1 |
| Coles, JP | 1 |
| Gupta, AK | 2 |
| Pickard, JD | 1 |
| Menon, DK | 2 |
| Yu, BW | 1 |
| Xue, QS | 1 |
| Xia, M | 1 |
| Wang, ZJ | 1 |
| Chen, HZ | 1 |
| Cruz, J | 1 |
| Karabinis, A | 1 |
| Mandragos, K | 1 |
| Stergiopoulos, S | 1 |
| Komnos, A | 1 |
| Soukup, J | 1 |
| Speelberg, B | 1 |
| Kirkham, AJ | 1 |
| Huang, SJ | 2 |
| Shieh, JS | 1 |
| Fu, M | 1 |
| Kao, MC | 1 |
| Statler, KD | 1 |
| Alexander, H | 1 |
| Vagni, V | 1 |
| Dixon, CE | 1 |
| Clark, RS | 1 |
| Jenkins, L | 1 |
| Huettemann, E | 1 |
| Jung, A | 1 |
| Vogelsang, H | 1 |
| Hout, Nv | 1 |
| Sakka, SG | 1 |
| Corbett, SM | 1 |
| Moore, J | 1 |
| Rebuck, JA | 1 |
| Rogers, FB | 1 |
| Greene, CM | 1 |
| Chiu, WT | 1 |
| Lin, TJ | 1 |
| Lin, JW | 1 |
| Chang, CK | 1 |
| Chen, HY | 1 |
| Eberspächer, E | 1 |
| Heimann, K | 1 |
| Hollweck, R | 1 |
| Schneider, G | 1 |
| Sabsovich, I | 1 |
| Rehman, Z | 1 |
| Yunen, J | 1 |
| Coritsidis, G | 1 |
| Peeters, MY | 1 |
| Kuiper, H | 1 |
| Greijdanus, B | 1 |
| van der Naalt, J | 1 |
| Knibbe, CA | 1 |
| Uges, DR | 1 |
| Rosen, DJ | 1 |
| Nicoara, A | 1 |
| Koshy, N | 1 |
| Wedderburn, RV | 1 |
| Adembri, C | 1 |
| Venturi, L | 1 |
| Pellegrini-Giampietro, DE | 1 |
| Sun, J | 1 |
| Wang, L | 1 |
| Shen, J | 1 |
| Wang, Z | 1 |
| Qian, Y | 1 |
| Cattano, D | 1 |
| Forfori, F | 1 |
| Giunta, F | 1 |
| McArthur, CJ | 1 |
| Gin, T | 1 |
| McLaren, IM | 1 |
| Critchley, JA | 1 |
| Oh, TE | 1 |
| Fowler, SB | 1 |
| Hertzog, J | 1 |
| Wagner, BK | 1 |
| Bullock, R | 2 |
| Stewart, L | 2 |
| Rafferty, C | 2 |
| Teasdale, GM | 2 |
| Fitch, W | 1 |
| Canivet, JL | 1 |
| Gustad, K | 1 |
| Leclercq, P | 1 |
| Damas, P | 1 |
| Lamy, M | 1 |
| Hilton, DL | 1 |
| Einhaus, SL | 1 |
| Meric, AL | 1 |
| White, RP | 1 |
| Schweitzer, JB | 1 |
| Park, MR | 1 |
| Robertson, JT | 1 |
| Hollrigel, GS | 1 |
| Toth, K | 1 |
| Soltesz, I | 1 |
| Albanèse, J | 1 |
| Arnaud, S | 1 |
| Rey, M | 1 |
| Thomachot, L | 1 |
| Alliez, B | 1 |
| Martin, C | 1 |
| Tecoult, E | 1 |
| Mesenge, H | 1 |
| Stutzmann, AM | 1 |
| Plotkine, M | 1 |
| Wahl, F | 1 |
| Moons, KG | 1 |
| Bouman, EA | 1 |
| Kruijswijk, JE | 1 |
| de Smet, AM | 1 |
| Matta, BF | 1 |
| Swami, A | 1 |
| Kahveci, FS | 1 |
| Kahveci, N | 1 |
| Alkan, T | 1 |
| Goren, B | 1 |
| Korfali, E | 1 |
| Ozluk, K | 1 |
| Mizuno, J | 1 |
| Sugimoto, S | 1 |
| Tsutsui, T | 1 |
| Machida, K | 1 |
| Sakai, K | 1 |
| Ruggiero, A | 1 |
| Giordano, L | 1 |
| Buffardi, G | 1 |
| Lazzaro, P | 1 |
| Viscidi, E | 1 |
| Pinaud, M | 2 |
| Lelausque, JN | 2 |
| Chetanneau, A | 2 |
| Fauchoux, N | 2 |
| Menegalli, D | 2 |
| Souron, R | 2 |
| Weinstabl, C | 1 |
| Mayer, N | 1 |
| Hammerle, AF | 1 |
| Spiss, CK | 1 |
| Wright, PJ | 1 |
| Murray, RJ | 1 |
| Hartung, HJ | 2 |
| Mangez, JF | 1 |
| Roux, P | 1 |
| Menguy, E | 1 |
| Alibert, F | 1 |
| Winckler, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study of the Safety and Efficacy of Analgesia-first Minimal Sedation as an Early Antihypertensive Treatment for Spontaneous Intracerebral Hemorrhage[NCT03207100] | 338 participants (Actual) | Interventional | 2017-12-06 | Completed | |||
| Assessment of EEG Slow Wave Activity in Comatose Cardiac Arrest Survivors Under Propofol Anesthesia[NCT04506788] | 25 participants (Actual) | Observational | 2015-06-15 | Completed | |||
| Assessment of EEG Changes During Induction of Propofol Anesthesia Using Wireless Measurement Devices[NCT03943745] | 50 participants (Anticipated) | Observational | 2018-10-25 | Recruiting | |||
| Assessment of Hypoxic Brain Injury by Analyzing Propofol-induced EEG Changes[NCT03485781] | 102 participants (Actual) | Observational | 2017-10-12 | Completed | |||
| the Research of Analgesia and Sedation Effect of Remifentanil on ICU Short Operation[NCT02635802] | Phase 4 | 1,500 participants (Anticipated) | Interventional | 2015-12-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
11 reviews available for propofol and Brain Injuries
| Article | Year |
|---|---|
The Impact of Sedative Choice on Intracranial and Systemic Physiology in Moderate to Severe Traumatic Brain Injury: A Scoping Review.
Topics: Adult; Analgesics, Opioid; Brain Injuries; Brain Injuries, Traumatic; Dexmedetomidine; Humans; Hypno | 2023 |
Comparison of the safety and efficacy of propofol with midazolam for sedation of patients with severe traumatic brain injury: a meta-analysis.
Topics: Anesthesia; Brain Injuries; Cerebrovascular Circulation; Conscious Sedation; Drug Monitoring; Female | 2014 |
Optimizing sedation in patients with acute brain injury.
Topics: Analgesia; Brain Injuries; Critical Care; Critical Illness; Deep Sedation; Humans; Hypnotics and Sed | 2016 |
New insights in the systemic and molecular underpinnings of general anesthetic actions mediated by γ-aminobutyric acid A receptors.
Topics: Anesthesia, General; Anesthetics, General; Brain Injuries; GABAergic Neurons; Hippocampus; Humans; I | 2016 |
Update on the propofol infusion syndrome in ICU management of patients with head injury.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Brain Injuries; Critical Care; Dose-Response Rela | 2008 |
Propofol infusion syndrome: update of clinical manifestation and pathophysiology.
Topics: Acidosis; Acute Disease; Adult; Age Factors; Anesthetics, Intravenous; Animals; Bradycardia; Brain I | 2009 |
Traumatic brain injury: neuroprotective anaesthetic techniques, an update.
Topics: Adolescent; Adult; Brain Injuries; Cell Death; Central Nervous System Depressants; Craniocerebral Tr | 2009 |
Sedation for critically ill adults with severe traumatic brain injury: a systematic review of randomized controlled trials.
Topics: Adult; Analgesics, Opioid; Benzodiazepines; Brain Injuries; Etomidate; Humans; Hypnotics and Sedativ | 2011 |
Too much of a good thing? Tracing the history of the propofol infusion syndrome.
Topics: Accidents, Traffic; Acute Kidney Injury; Adolescent; Adult; Anuria; Brain Injuries; Critical Care; D | 2007 |
Neuroprotective effects of propofol in acute cerebral injury.
Topics: Animals; Brain Injuries; Humans; Neuroprotective Agents; Propofol | 2007 |
Pharmacological interventions for agitation in head-injured patients in the acute care setting.
Topics: Adult; Brain Injuries; Critical Care; Dose-Response Relationship, Drug; Drug Administration Schedule | 1995 |
14 trials available for propofol and Brain Injuries
| Article | Year |
|---|---|
[Effects of dexmedetomidine on sedation and β-endorphin in traumatic brain injury: a comparative study with propofol].
Topics: Adult; beta-Endorphin; Blood Pressure; Brain Injuries; Dexmedetomidine; Female; Humans; Hypnotics an | 2013 |
Levels of F2-isoprostanes, F4-neuroprostanes, and total nitrate/nitrite in plasma and cerebrospinal fluid of patients with traumatic brain injury.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Biomarkers; Brain Injuries; Chromatography, Gas; | 2015 |
Effect of propofol on breathing stability in adult ICU patients with brain damage.
Topics: Adolescent; Adult; Aged; Brain Damage, Chronic; Brain Injuries; Female; Humans; Hypnotics and Sedati | 2010 |
Cerebral microdialysis effects of propofol versus midazolam in severe traumatic brain injury.
Topics: Adult; Biomarkers; Brain Chemistry; Brain Injuries; Cerebral Cortex; Female; Glucose; Glutamic Acid; | 2012 |
A pilot study of cerebral and haemodynamic physiological changes during sedation with dexmedetomidine or propofol in patients with acute brain injury.
Topics: Body Temperature; Brain Injuries; Consciousness Monitors; Cross-Over Studies; Dexmedetomidine; Glasg | 2012 |
The effects of large-dose propofol on cerebrovascular pressure autoregulation in head-injured patients.
Topics: Adult; Blood Flow Velocity; Blood Pressure; Brain Injuries; Cerebrovascular Circulation; Female; Hom | 2003 |
Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308].
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Analgesics, Opioid; Brain Injuries; Drug Monitoring; | 2004 |
Fuzzy logic control for intracranial pressure via continuous propofol sedation in a neurosurgical intensive care unit.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Biomedical Engineering; Brain Injuries; Critical Care; F | 2006 |
Effects of propofol vs methohexital on neutrophil function and immune status in critically ill patients.
Topics: Adult; Aged; Anesthetics, Intravenous; Antigens, CD; Biomarkers; Brain Injuries; Conscious Sedation; | 2006 |
Multicenter evaluation of propofol for head-injured patients in Taiwan.
Topics: Adolescent; Adult; Aged; Brain Injuries; Child; Female; Glasgow Coma Scale; Humans; Hypnotics and Se | 2006 |
Gastric emptying following brain injury: effects of choice of sedation and intracranial pressure.
Topics: Acetaminophen; Adult; Brain Injuries; Conscious Sedation; Drug Therapy, Combination; Female; Gastric | 1995 |
Continuous monitoring of jugular bulb oxygen saturation and the effect of drugs acting on cerebral metabolism.
Topics: Adolescent; Adult; Aged; Brain; Brain Injuries; Child; Child, Preschool; Dose-Response Relationship, | 1993 |
Propofol sedation in severe head injury fails to control high ICP, but reduces brain metabolism.
Topics: Adolescent; Adult; Brain; Brain Edema; Brain Injuries; Child; Conscious Sedation; Energy Metabolism; | 1994 |
Ketamine decreases intracranial pressure and electroencephalographic activity in traumatic brain injury patients during propofol sedation.
Topics: Adolescent; Adult; Anesthetics, Dissociative; Brain Injuries; Dose-Response Relationship, Drug; Elec | 1997 |
56 other studies available for propofol and Brain Injuries
| Article | Year |
|---|---|
Brain Responses to Propofol in Advance of Recovery from Coma and Disorders of Consciousness: A Preliminary Study.
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Brain Injuries; Coma; Consciousness; Consciousn | 2022 |
Propofol weakens hypoxia-aroused apoptosis and autophagy via elevating microRNA-137 in neurocytes.
Topics: Apoptosis; Autophagy; Brain; Brain Injuries; Humans; MAP Kinase Signaling System; MicroRNAs; Phospha | 2020 |
Effects of Norepinephrine, Propofol, and Hemoglobin Concentration on Dynamic Measurements of Cerebrovascular Reactivity in Acute Brain Injury.
Topics: Adult; Aged; Brain Injuries; Cerebrovascular Circulation; Female; Glycated Hemoglobin; Homeostasis; | 2021 |
Propofol Attenuates Inflammatory Damage via Inhibiting NLRP1-Casp1-Casp6 Signaling in Ischemic Brain Injury.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Brain Injuries; Caspas | 2020 |
Potential EEG biomarkers of sedation doses in intensive care patients unveiled by using a machine learning approach.
Topics: Adult; Brain Injuries; Cohort Studies; Critical Care; Dose-Response Relationship, Drug; Electroencep | 2019 |
Potential role of the cAMP/PKA/CREB signalling pathway in hypoxic preconditioning and effect on propofol‑induced neurotoxicity in the hippocampus of neonatal rats.
Topics: Animals; Animals, Newborn; Apoptosis; Brain Injuries; Cyclic AMP; Cyclic AMP Response Element-Bindin | 2019 |
Propofol administration modulates AQP-4 expression and brain edema after traumatic brain injury.
Topics: Animals; Aquaporin 4; Astrocytes; Brain Edema; Brain Injuries; Cells, Cultured; Enzyme Activation; G | 2013 |
Neural and immune consequences of traumatic brain injury: does propofol reduce the impact?
Topics: Anesthetics, Intravenous; Animals; Brain Injuries; Macrophage Activation; Male; Microglia; NADPH Oxi | 2013 |
Propofol limits microglial activation after experimental brain trauma through inhibition of nicotinamide adenine dinucleotide phosphate oxidase.
Topics: Anesthetics, Intravenous; Animals; Brain Injuries; Cell Count; Cell Line; Cerebral Cortex; Cognition | 2013 |
Propofol impairs neurogenesis and neurologic recovery and increases mortality rate in adult rats after traumatic brain injury.
Topics: Animals; Brain; Brain Injuries; Cognition; Dose-Response Relationship, Drug; Hypnotics and Sedatives | 2014 |
Are we offtrack using propofol for sedation after traumatic brain injury?
Topics: Animals; Brain Injuries; Hypnotics and Sedatives; Male; Neurogenesis; Propofol | 2014 |
Intracranial pressure response after pharmacologic treatment of intracranial hypertension.
Topics: Adult; Brain Injuries; Critical Care; Documentation; Female; Fentanyl; Humans; Hypnotics and Sedativ | 2014 |
Pharmacologic Treatment Reduces Pressure Times Time Dose and Relative Duration of Intracranial Hypertension.
Topics: Adult; Barbiturates; Brain Injuries; Dose-Response Relationship, Drug; Female; Fentanyl; Humans; Hyp | 2016 |
Propofol ameliorates calpain-induced collapsin response mediator protein-2 proteolysis in traumatic brain injury in rats.
Topics: Animals; Blotting, Western; Brain Injuries; Calpain; Intercellular Signaling Peptides and Proteins; | 2015 |
Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro-Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult Mice.
Topics: Animals; Blood Pressure; Brain Injuries; Brain-Derived Neurotrophic Factor; Caspase 3; Cell Death; G | 2016 |
Propofol Pretreatment Fails to Provide Neuroprotection Following a Surgically Induced Brain Injury Rat Model.
Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Brain; Brain Edema; Brain Injuries; Disease Mod | 2016 |
Neurotoxic Properties of Propofol Sedation Following Traumatic Brain Injury.
Topics: Animals; Brain Injuries; Brain-Derived Neurotrophic Factor; Propofol; Receptor, Nerve Growth Factor | 2016 |
[Brain damage after general anesthesia].
Topics: Adolescent; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarkers; Brai | 2016 |
Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury.
Topics: Aged; Anesthetics, Intravenous; Brain; Brain Injuries; Coma; Electroencephalography; Female; Humans; | 2017 |
Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury.
Topics: Aged; Anesthetics, Intravenous; Brain; Brain Injuries; Coma; Electroencephalography; Female; Humans; | 2017 |
Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury.
Topics: Aged; Anesthetics, Intravenous; Brain; Brain Injuries; Coma; Electroencephalography; Female; Humans; | 2017 |
Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury.
Topics: Aged; Anesthetics, Intravenous; Brain; Brain Injuries; Coma; Electroencephalography; Female; Humans; | 2017 |
Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury.
Topics: Aged; Anesthetics, Intravenous; Brain; Brain Injuries; Coma; Electroencephalography; Female; Humans; | 2017 |
Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury.
Topics: Aged; Anesthetics, Intravenous; Brain; Brain Injuries; Coma; Electroencephalography; Female; Humans; | 2017 |
Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury.
Topics: Aged; Anesthetics, Intravenous; Brain; Brain Injuries; Coma; Electroencephalography; Female; Humans; | 2017 |
Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury.
Topics: Aged; Anesthetics, Intravenous; Brain; Brain Injuries; Coma; Electroencephalography; Female; Humans; | 2017 |
Pilot Study of Propofol-induced Slow Waves as a Pharmacologic Test for Brain Dysfunction after Brain Injury.
Topics: Aged; Anesthetics, Intravenous; Brain; Brain Injuries; Coma; Electroencephalography; Female; Humans; | 2017 |
Sedation of Patients With Disorders of Consciousness During Neuroimaging: Effects on Resting State Functional Brain Connectivity.
Topics: Adult; Age of Onset; Aged; Brain; Brain Injuries; Cerebral Cortex; Conscious Sedation; Consciousness | 2017 |
[Influence of propofol on brain tissue oxygenation in traumatic brain injury patients under different modes of ventilation].
Topics: Adult; Brain; Brain Injuries; Female; Humans; Male; Middle Aged; Oxygen; Propofol; Respiration, Arti | 2008 |
Monitoring biochemical parameters as an early sign of propofol infusion syndrome: false feeling of security.
Topics: Adolescent; Anesthetics, Intravenous; Brain Injuries; Drug Monitoring; Fatal Outcome; Humans; Male; | 2009 |
Propofol: neuroprotection in an in vitro model of traumatic brain injury.
Topics: Animals; Brain Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; Hypnotics and Sed | 2009 |
Effects of the neurological wake-up test on intracranial pressure and cerebral perfusion pressure in brain-injured patients.
Topics: Adolescent; Adult; Aged; Brain Injuries; Diagnostic Techniques, Neurological; Female; Humans; Hypnot | 2009 |
Propofol infusion syndrome with arrhythmia, myocardial fat accumulation and cardiac failure.
Topics: Arrhythmias, Cardiac; Brain Edema; Brain Injuries; Child; Diagnosis, Differential; Fatal Outcome; He | 2009 |
Propofol's effects on phagocytosis, proliferation, nitrate production, and cytokine secretion in pressure-stimulated microglial cells.
Topics: Anesthetics, Intravenous; Biological Assay; Brain Injuries; Cell Division; Cell Line; Cytokines; Hum | 2011 |
Effect of continuous cerebrospinal fluid drainage on therapeutic intensity in severe traumatic brain injury.
Topics: Adolescent; Adult; Aged; Blood Gas Analysis; Brain Injuries; Central Nervous System Infections; Cere | 2012 |
Propofol infusion syndrome heralded by ECG changes.
Topics: Acidosis; Brain Injuries; Electrocardiography; Humans; Hypnotics and Sedatives; Intracranial Hyperte | 2012 |
Metabolic suppressive therapy as a treatment for intracranial hypertension--why it works and when it fails.
Topics: Anticonvulsants; Biomarkers; Brain Injuries; Carbon Dioxide; Cerebrovascular Circulation; Humans; In | 2002 |
Tolerability of bolus versus continuous gastric feeding in brain-injured patients.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anti-Ulcer | 2002 |
Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 9. Use of sedation and neuromuscular blockade in the treatment of severe pediatric traumatic brain injury.
Topics: Acute Disease; Adolescent; Analgesics; Brain Injuries; Child; Child, Preschool; Contraindications; C | 2003 |
[The influences of propofol on different kinds of brain injuries in rat brain slices].
Topics: Animals; Brain; Brain Injuries; Cerebral Cortex; Dose-Response Relationship, Drug; Free Radical Scav | 2003 |
Hyperventilation.
Topics: Adult; Blood Pressure; Brain Injuries; Female; Humans; Hyperventilation; Hypnotics and Sedatives; In | 2003 |
Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats.
Topics: Anesthetics; Animals; Brain; Brain Injuries; Cell Survival; Cognition Disorders; Diazepam; Disease M | 2006 |
Survival of propofol infusion syndrome in a head-injured patient.
Topics: Acidosis, Lactic; Adult; Anesthetics, Intravenous; Brain Injuries; Drug Therapy, Combination; Humans | 2006 |
The effect of electroencephalogram-targeted high- and low-dose propofol infusion on histopathological damage after traumatic brain injury in the rat.
Topics: Animals; Brain; Brain Injuries; Caspase 3; Dose-Response Relationship, Drug; Electroencephalography; | 2006 |
Propofol infusion syndrome: a case of increasing morbidity with traumatic brain injury.
Topics: Acidosis; Acute Kidney Injury; Adolescent; Anesthetics, Intravenous; Brain Injuries; Fatal Outcome; | 2007 |
Gas chromatography-mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Brain Injuries; Gas Chromatography-Mass Spectrometry; H | 2007 |
Effect of propofol on mucous permeability and inflammatory mediators expression in the intestine following traumatic brain injury in rats.
Topics: Animals; Brain Injuries; Dose-Response Relationship, Drug; Endotoxins; Gene Expression Regulation; H | 2007 |
Clinical use of xenon in 2 elderly patients.
Topics: Aged; Androstanols; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarke | 2008 |
Massive ketonuria during sedation with propofol in a 12 year old girl with severe head trauma.
Topics: Brain Injuries; Calorimetry; Child; Energy Metabolism; Female; Humans; Intracranial Pressure; Ketone | 1994 |
Early assessment of neurologic deficits in the fluid percussion model of brain injury.
Topics: Anesthesia; Animals; Behavior, Animal; Blood Pressure; Brain Injuries; Brain Stem; Cats; Cerebral He | 1993 |
Neuroprotection by propofol in acute mechanical injury: role of GABAergic inhibition.
Topics: Acute Disease; Anesthetics, Intravenous; Animals; Brain Injuries; Dendrites; gamma-Aminobutyric Acid | 1996 |
Influence of anesthesia protocol in experimental traumatic brain injury.
Topics: Anesthesia; Animals; Brain Injuries; Chloral Hydrate; Halothane; Hand Strength; Male; Mice; Motor Ac | 2000 |
Long-term propofol infusion and cardiac failure in adult head-injured patients.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Brain Injuries; Heart Failure; Humans; Infusions, Intra | 2001 |
Propofol use in head-injury patients.
Topics: Adult; Brain Injuries; Cause of Death; Conscious Sedation; Dose-Response Relationship, Drug; Heart F | 2001 |
Propofol versus isoflurane anesthesia under hypothermic conditions: effects on intracranial pressure and local cerebral blood flow after diffuse traumatic brain injury in the rat.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blood Gas Analysis; Blood Pressure; Body | 2001 |
[Efficacy of propofol in controlling myoclonus during rewarming in a brain hypothermia patient].
Topics: Adult; Anticonvulsants; Brain Injuries; Humans; Hypothermia, Induced; Infusions, Intravenous; Inject | 2002 |
[Post-heparin lipolytic activity in cranial trauma patients subjected to sedation with propofol].
Topics: Adult; Brain Injuries; Cell Count; Fatty Acids, Nonesterified; Heparin; Humans; Macrophages; Propofo | 1991 |
[Effects of Diprivan on cerebral blood flow, intracranial pressure and cerebral metabolism in head injured patients].
Topics: Adolescent; Adult; Brain; Brain Injuries; Cerebrovascular Circulation; Glasgow Coma Scale; Hemodynam | 1991 |
Effects of propofol on cerebral hemodynamics and metabolism in patients with brain trauma.
Topics: Aged; Anesthetics; Brain Injuries; Carbon Dioxide; Cerebrovascular Circulation; Hemodynamics; Humans | 1990 |
[The effects of propofol bolus administration on the intracranial pressure in craniocerebral trauma].
Topics: Adult; Brain Injuries; Humans; Intracranial Pressure; Middle Aged; Propofol | 1990 |
Penetrating craniocerebral airgun injury. Anaesthetic management with propofol infusion and review of recent reports.
Topics: Adolescent; Anesthesia, Intravenous; Anesthetics; Brain Injuries; Humans; Male; Phenols; Propofol; R | 1989 |
[Modification of intracranial pressure by propofol (Disoprivan). Initial results].
Topics: Adult; Aged; Brain Injuries; Cerebrovascular Circulation; Female; Hemodynamics; Humans; Intracranial | 1987 |
[Intracranial pressure in patients with craniocerebral trauma after administration of propofol and thiopental].
Topics: Adolescent; Adult; Aged; Anesthesia; Blood Gas Analysis; Blood Pressure; Brain Injuries; Cerebrovasc | 1987 |
[Propofol and methohexitone: comparative effects on cerebral perfusion pressure].
Topics: Adult; Anesthetics; Blood Pressure; Brain Injuries; Cerebrovascular Circulation; Female; Humans; Int | 1987 |