propofol has been researched along with Brain Edema in 19 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propofol significantly reduces neurological dysfunction, BBB permeability, brain edema, inflammation, and oxidative stress, all of which were reversed by LY294002." | 7.91 | Propofol Reduces Inflammatory Brain Injury after Subarachnoid Hemorrhage: Involvement of PI3K/Akt Pathway. ( Chen, Q; Shi, SS; Tu, XK; Zhang, HB, 2019) |
| "The neuroprotective effect of propofol against intracerebral hemorrhage (ICH) in rats was investigated." | 7.75 | Protective effect of propofol against intracerebral hemorrhage injury in rats. ( Dong, Z; Li, QG; Ma, J; Wang, JR, 2009) |
| "To investigate the effects of propofol, midazolam and thiopental sodium on outcomes and amino acid accumulation in focal cerebral ischemia-reperfusion in rats." | 7.72 | Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats. ( Chen, L; Gong, Q; Xiao, C, 2003) |
| "Post-operative cerebral edema is a threat for patients performed gliomas resection." | 5.42 | Effects of propofol and sevoflurane on aquaporin-4 and aquaporin-9 expression in patients performed gliomas resection. ( Chang, FF; Dong, H; Lu, SJ; Qian, H; Song, CY; Yang, WC; Yue, ZY; Zhang, R; Zhou, LJ, 2015) |
| "Propofol is a potent and widely used central-acting sedative drug." | 5.35 | Propofol infusion syndrome with arrhythmia, myocardial fat accumulation and cardiac failure. ( Jorens, PG; Van den Eynden, GG, 2009) |
| "The study indicates that before as well as during hyperventilation, subdural ICP and AVDo2 are lower and CPP higher in propofol-anesthetized patients compared with patients anesthetized with isoflurane or sevoflurane." | 5.10 | Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia. ( Cold, GE; Hauerberg, J; Holst, P; Landsfeldt, U; Mau, S; Olsen, KS; Petersen, CB; Petersen, KD, 2003) |
| "Propofol significantly reduces neurological dysfunction, BBB permeability, brain edema, inflammation, and oxidative stress, all of which were reversed by LY294002." | 3.91 | Propofol Reduces Inflammatory Brain Injury after Subarachnoid Hemorrhage: Involvement of PI3K/Akt Pathway. ( Chen, Q; Shi, SS; Tu, XK; Zhang, HB, 2019) |
| "The neuroprotective effect of propofol against intracerebral hemorrhage (ICH) in rats was investigated." | 3.75 | Protective effect of propofol against intracerebral hemorrhage injury in rats. ( Dong, Z; Li, QG; Ma, J; Wang, JR, 2009) |
| "To investigate the effects of propofol, midazolam and thiopental sodium on outcomes and amino acid accumulation in focal cerebral ischemia-reperfusion in rats." | 3.72 | Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats. ( Chen, L; Gong, Q; Xiao, C, 2003) |
| "Post-operative cerebral edema is a threat for patients performed gliomas resection." | 1.42 | Effects of propofol and sevoflurane on aquaporin-4 and aquaporin-9 expression in patients performed gliomas resection. ( Chang, FF; Dong, H; Lu, SJ; Qian, H; Song, CY; Yang, WC; Yue, ZY; Zhang, R; Zhou, LJ, 2015) |
| "Propofol post-treatment significantly reduced cerebral edema (P < 0." | 1.39 | Effect of propofol post-treatment on blood-brain barrier integrity and cerebral edema after transient cerebral ischemia in rats. ( Cui, HS; Kim, JM; Kim, SY; Koo, BN; Lee, JE; Lee, JH; Shin, SK, 2013) |
| "Cerebral edema is a major threat for stroke victims." | 1.35 | Propofol pretreatment attenuates aquaporin-4 over-expression and alleviates cerebral edema after transient focal brain ischemia reperfusion in rats. ( Lan, YP; Tang, HF; Zheng, YY; Zhu, SM, 2008) |
| "Propofol is a potent and widely used central-acting sedative drug." | 1.35 | Propofol infusion syndrome with arrhythmia, myocardial fat accumulation and cardiac failure. ( Jorens, PG; Van den Eynden, GG, 2009) |
| "Propofol was added during the OGD phase of the model." | 1.35 | Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation. ( Pan, CF; Xiong, XX; Zheng, YY; Zhu, SM, 2009) |
| "The use of pharmacologic coma (PC) to treat status epilepticus (SE) is not always successful, and there are no guidelines for the duration of PC in an attempt to achieve seizure control." | 1.32 | Now we lay them down to sleep: ethical issues with the use of pharmacologic coma for adult status epilepticus. ( Bramstedt, KA; Morris, HH; Tanner, A, 2004) |
| "Propofol has been known to suppress glucose metabolism in the brain and possess neuroprotective properties in cerebral ischaemia." | 1.31 | Effects of propofol on lactate accumulation and oedema formation in focal cerebral ischaemia in hyperglycaemic rats. ( Arai, T; Fukuda, K; Inubushi, T; Ishii, H; Morikawa, S; Segawa, H, 2002) |
| "In the other 15 cats, cytotoxic brain edema (CBE) was created by an acute reduction in blood osmolality." | 1.30 | The effects of intravenous anesthetics on intracranial pressure and cerebral perfusion pressure in two feline models of brain edema. ( Nimkoff, L; Quinn, C; Sagy, M; Silver, P, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (21.05) | 18.2507 |
| 2000's | 9 (47.37) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, HB | 1 |
| Tu, XK | 1 |
| Chen, Q | 1 |
| Shi, SS | 1 |
| Ding, Z | 1 |
| Zhang, J | 2 |
| Xu, J | 1 |
| Sheng, G | 1 |
| Huang, G | 1 |
| Lee, JH | 1 |
| Cui, HS | 1 |
| Shin, SK | 1 |
| Kim, JM | 1 |
| Kim, SY | 1 |
| Lee, JE | 1 |
| Koo, BN | 1 |
| Yang, WC | 1 |
| Zhou, LJ | 1 |
| Zhang, R | 1 |
| Yue, ZY | 1 |
| Dong, H | 1 |
| Song, CY | 1 |
| Qian, H | 1 |
| Lu, SJ | 1 |
| Chang, FF | 1 |
| Pakkianathan, C | 1 |
| Benggon, M | 1 |
| Khatibi, NH | 1 |
| Chen, H | 1 |
| Marcantonio, S | 1 |
| Applegate, R | 1 |
| Tang, J | 1 |
| Zhang, L | 1 |
| Jin, J | 1 |
| Yao, J | 1 |
| Yue, Z | 1 |
| Wei, Y | 1 |
| Yang, W | 1 |
| Fu, S | 1 |
| Li, W | 1 |
| Zheng, YY | 2 |
| Lan, YP | 1 |
| Tang, HF | 1 |
| Zhu, SM | 3 |
| Ma, J | 1 |
| Dong, Z | 1 |
| Li, QG | 1 |
| Wang, JR | 1 |
| Jorens, PG | 1 |
| Van den Eynden, GG | 1 |
| Xiong, XX | 1 |
| Pan, CF | 2 |
| Petersen, KD | 1 |
| Landsfeldt, U | 1 |
| Cold, GE | 1 |
| Petersen, CB | 1 |
| Mau, S | 1 |
| Hauerberg, J | 1 |
| Holst, P | 1 |
| Olsen, KS | 1 |
| Chen, L | 1 |
| Gong, Q | 1 |
| Xiao, C | 1 |
| Bramstedt, KA | 1 |
| Morris, HH | 1 |
| Tanner, A | 1 |
| Stewart, L | 1 |
| Bullock, R | 1 |
| Rafferty, C | 1 |
| Fitch, W | 1 |
| Teasdale, GM | 1 |
| Van Aken, H | 1 |
| Van Hemelrijck, J | 1 |
| Nimkoff, L | 1 |
| Quinn, C | 1 |
| Silver, P | 1 |
| Sagy, M | 1 |
| Braunfeld, MY | 1 |
| Ishii, H | 1 |
| Arai, T | 1 |
| Segawa, H | 1 |
| Morikawa, S | 1 |
| Inubushi, T | 1 |
| Fukuda, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Vasopressors on Brain Oxygenation and Microcirculation in Anesthetized Patients With Cerebral Tumors[NCT02713087] | Phase 4 | 48 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for propofol and Brain Edema
| Article | Year |
|---|---|
An overview of the influence of anesthesia on cerebral blood flow and cerebral metabolism.
Topics: Anesthesia; Anesthetics; Animals; Brain; Brain Edema; Cats; Cerebrovascular Circulation; Humans; Int | 1993 |
2 trials available for propofol and Brain Edema
| Article | Year |
|---|---|
Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Anesthetics, Inhalation; Anest | 2003 |
Propofol sedation in severe head injury fails to control high ICP, but reduces brain metabolism.
Topics: Adolescent; Adult; Brain; Brain Edema; Brain Injuries; Child; Conscious Sedation; Energy Metabolism; | 1994 |
16 other studies available for propofol and Brain Edema
| Article | Year |
|---|---|
Propofol Reduces Inflammatory Brain Injury after Subarachnoid Hemorrhage: Involvement of PI3K/Akt Pathway.
Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Edema; Cyclooxygenase 2; Disease Models, Animal; Enc | 2019 |
Propofol administration modulates AQP-4 expression and brain edema after traumatic brain injury.
Topics: Animals; Aquaporin 4; Astrocytes; Brain Edema; Brain Injuries; Cells, Cultured; Enzyme Activation; G | 2013 |
Effect of propofol post-treatment on blood-brain barrier integrity and cerebral edema after transient cerebral ischemia in rats.
Topics: Animals; Aquaporin 1; Aquaporin 4; Blood-Brain Barrier; Brain Edema; Hypoxia-Inducible Factor 1, alp | 2013 |
Effects of propofol and sevoflurane on aquaporin-4 and aquaporin-9 expression in patients performed gliomas resection.
Topics: Aquaporin 4; Aquaporins; Blotting, Western; Brain; Brain Edema; Brain Neoplasms; Female; Glioma; Hom | 2015 |
Propofol Pretreatment Fails to Provide Neuroprotection Following a Surgically Induced Brain Injury Rat Model.
Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Brain; Brain Edema; Brain Injuries; Disease Mod | 2016 |
Effects of Propofol on Excitatory and Inhibitory Amino Acid Neurotransmitter Balance in Rats with Neurogenic Pulmonary Edema Induced by Subarachnoid Hemorrhage.
Topics: Animals; Brain; Brain Edema; Disease Models, Animal; Excitatory Amino Acids; gamma-Aminobutyric Acid | 2016 |
Propofol pretreatment attenuates aquaporin-4 over-expression and alleviates cerebral edema after transient focal brain ischemia reperfusion in rats.
Topics: Anesthetics, Intravenous; Animals; Aquaporin 4; Brain Edema; Ischemic Attack, Transient; Male; Propo | 2008 |
Protective effect of propofol against intracerebral hemorrhage injury in rats.
Topics: Animals; Behavior, Animal; Brain; Brain Edema; Caspase 3; Cerebral Hemorrhage; Collagenases; Male; M | 2009 |
Propofol infusion syndrome with arrhythmia, myocardial fat accumulation and cardiac failure.
Topics: Arrhythmias, Cardiac; Brain Edema; Brain Injuries; Child; Diagnosis, Differential; Fatal Outcome; He | 2009 |
Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation.
Topics: Animals; Animals, Newborn; Aquaporin 4; Astrocytes; Brain Diseases; Brain Edema; Cell Hypoxia; Cell | 2009 |
[Effect of propofol upon ammonia-induced neocortical astrocyte swelling and aquaporin-4 expression].
Topics: Animals; Aquaporin 4; Astrocytes; Brain Edema; Cells, Cultured; Propofol; Rats | 2009 |
Effects of propofol, midazolam and thiopental sodium on outcome and amino acids accumulation in focal cerebral ischemia-reperfusion in rats.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Edema; Brain Ischemia; Excitatory Amino Acids; Male; M | 2003 |
Now we lay them down to sleep: ethical issues with the use of pharmacologic coma for adult status epilepticus.
Topics: Adult; Anticonvulsants; Brain; Brain Edema; Coma; Drug Therapy; Fatal Outcome; Female; Humans; Hypno | 2004 |
The effects of intravenous anesthetics on intracranial pressure and cerebral perfusion pressure in two feline models of brain edema.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Blood Pressure; Brain Edema; Cats; Cerebrov | 1997 |
Case presentation: fulminant hepatic failure.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Brain Death; Brain Edema; Female; Hepatic Encephalop | 1999 |
Effects of propofol on lactate accumulation and oedema formation in focal cerebral ischaemia in hyperglycaemic rats.
Topics: Anesthetics, Intravenous; Animals; Brain; Brain Edema; Brain Ischemia; Hyperglycemia; Lactic Acid; M | 2002 |