propofol has been researched along with Bone Fractures in 21 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors performed a prospective, double-blinded, randomized trial with emergency department (ED) patients requiring procedural sedation and analgesia (PSA) for repair of deep traumatic lacerations and reduction of bone fractures, to compare the ketamine/propofol (ketofol) combination with the midazolam/fentanyl (MF) combination." | 5.15 | Ketamine/propofol versus midazolam/fentanyl for procedural sedation and analgesia in the emergency department: a randomized, prospective, double-blind trial. ( Ashraf, H; Golshani, K; Labaf, A; Moharari, RS; Nejati, A, 2011) |
| "The objective was to assess the effect on stress biomarkers of supplemental opioid to a standard propofol dosing protocol for emergency department (ED) procedural sedation (PS)." | 2.78 | Randomized clinical trial of the effect of supplemental opioids in procedural sedation with propofol on serum catecholamines. ( Gray, RO; Ho, JD; Miner, JR; Moore, JC; Patel, S; Plummer, D, 2013) |
| "Respiratory depression was defined as a change in ETCO(2) >10, an oxygen saturation of <90% at any time, or an absent ETCO(2) waveform at any time." | 2.73 | The effect of the assignment of a pre-sedation target level on procedural sedation using propofol. ( Biros, M; Huber, D; Miner, JR; Nichols, S, 2007) |
| "The frequency of psychosis emergence or confusion (54%) in Group A during the first 48 hours after surgery was significantly higher than the 30% figure in Group B." | 2.70 | Anesthesia with ketamine, propofol, and fentanyl decreases the frequency of postoperative psychosis emergence and confusion in schizophrenic patients. ( Katagai, H; Kudoh, A; Takazawa, T, 2002) |
| "Midazolam was the sedative agent used most commonly (45%), and morphine was the most frequently used analgesic agent (36%)." | 1.42 | Emergency department procedural sedation: the London experience. ( Baker, EC; Elkhodair, SM; Freund, Y; Glasebrook, WR; Harris, TR; Pott, JD, 2015) |
| " Detailed data concerning the dosage of PSA medications, adverse events, and ED times for patients requiring PSA for treatment of fractures, reductions of joint dislocations, and cardioversion for atrial fibrillation were collected." | 1.37 | Procedural sedation and analgesia in a Canadian ED: a time-in-motion study. ( Anstett, D; Bawden, J; Bond, K; Boyko, D; Fabris, G; Fassbender, K; Rowe, BH; Singh, M; Villa-Roel, C, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 9 (42.86) | 29.6817 |
| 2010's | 9 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, P | 1 |
| Liu, H | 1 |
| Wu, Y | 1 |
| Chen, D | 1 |
| Masquère, P | 1 |
| Lonjaret, L | 1 |
| Fourcade, O | 1 |
| Minville, V | 1 |
| Miner, JR | 3 |
| Moore, JC | 1 |
| Plummer, D | 2 |
| Gray, RO | 1 |
| Patel, S | 1 |
| Ho, JD | 1 |
| Navarro Suay, R | 1 |
| Castillejo Pérez, S | 1 |
| de las Heras Díez, J | 1 |
| Tamburri Bariain, R | 1 |
| Elkhodair, SM | 1 |
| Baker, EC | 1 |
| Glasebrook, WR | 1 |
| Pott, JD | 1 |
| Freund, Y | 1 |
| Harris, TR | 1 |
| Andolfatto, G | 1 |
| Willman, E | 1 |
| Bawden, J | 1 |
| Villa-Roel, C | 1 |
| Singh, M | 1 |
| Fabris, G | 1 |
| Bond, K | 1 |
| Boyko, D | 1 |
| Anstett, D | 1 |
| Fassbender, K | 1 |
| Rowe, BH | 1 |
| Nejati, A | 1 |
| Moharari, RS | 1 |
| Ashraf, H | 1 |
| Labaf, A | 1 |
| Golshani, K | 1 |
| Gallegos, J | 1 |
| Vaidya, P | 1 |
| D'Agati, D | 1 |
| Jayaram, G | 1 |
| Nguyen, T | 1 |
| Tripathi, A | 1 |
| Trivedi, JK | 1 |
| Reti, IM | 1 |
| Biros, M | 2 |
| Krieg, S | 1 |
| Johnson, C | 1 |
| Heegaard, W | 1 |
| Ohta, M | 1 |
| Oku, K | 1 |
| Mukai, K | 1 |
| Akiyama, K | 1 |
| Mizuno, Y | 1 |
| Migita, RT | 1 |
| Klein, EJ | 1 |
| Garrison, MM | 1 |
| Anderson, JL | 1 |
| Junkins, E | 1 |
| Pribble, C | 1 |
| Guenther, E | 1 |
| Huber, D | 1 |
| Nichols, S | 1 |
| Nishiyama, T | 1 |
| Sharieff, GQ | 1 |
| Trocinski, DR | 1 |
| Kanegaye, JT | 1 |
| Fisher, B | 1 |
| Harley, JR | 1 |
| Knab, J | 1 |
| Heupel, EW | 1 |
| Steinmann, D | 1 |
| Crespo, ML | 1 |
| Giménez, A | 1 |
| Bas, T | 1 |
| García, C | 1 |
| Puertes, IR | 1 |
| Viña, JR | 1 |
| Gaertner, E | 1 |
| Dilovski, K | 1 |
| Bourlon, S | 1 |
| Bistour, L | 1 |
| Pottecher, T | 1 |
| Matsuura, T | 1 |
| Okawa, I | 1 |
| Matsukawa, T | 1 |
| Furuya, A | 1 |
| Kudoh, A | 1 |
| Katagai, H | 1 |
| Takazawa, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Physiologic Stress During Procedural Sedation With and Without Alfentanil[NCT00997113] | Phase 4 | 20 participants (Actual) | Interventional | 2009-10-31 | Completed | ||
| Comparison Between Efficacy of Ketamine and Propofol Mixture With 1:6 Ratio and 1:4 Ratio for Endoscopic Retrograde Procedure Sedation[NCT03196479] | 58 participants (Actual) | Interventional | 2017-03-01 | Completed | |||
| A Randomized Double-blind Trial to Evaluate Ketamine-propofol Combination vs. Propofol Alone for Procedural Sedation and Analgesia in the Emergency Department.[NCT01211158] | Phase 3 | 284 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| Ketofol Versus Fentofol for Procedural Sedation of Children 3 to 17 Years Old: a Double-Blind Randomized Controlled Trial[NCT02079090] | Phase 3 | 30 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Moderate Versus Deep Procedural Sedation With Propofol in the Emergency Department[NCT02404610] | Phase 4 | 107 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| Effect of Dexmedetomidine of Gastrointestinal Motility[NCT04798482] | Phase 4 | 22 participants (Actual) | Interventional | 2021-09-14 | Completed | ||
| Application of Capnography Monitoring on the General Care Nursing Unit[NCT00457080] | 60 participants | Interventional | 2006-10-31 | Completed | |||
| Comparison of Ketamine Versus Co-Administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department[NCT01387139] | Phase 3 | 183 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial[NCT01269307] | 99 participants (Actual) | Interventional | 2010-06-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
change in serum catecholamine levels, values indicate a decrease over the procedure. These patients underwent fracture reduction procedures which are typically associated with an increase in catecholamines. (NCT00997113)
Timeframe: one minute prior to the start of the procedure and immediately at the end of sedation procedure (median time of procedure 12 minutes range 6-26 minutes
| Intervention | mcg/ml (Median) |
|---|---|
| Propofol | 87 |
| Propofol/Alfentanil | 106 |
Pain and recall were measured seperately by direct patient query. The patient was asked if they experienced any pain during the procedure. The patient was then asked if they could recall any part of the fracture reduction. Patients who had either pain with the procedure of recall of the procedure were counted as having pain or recall with the procedure. (NCT00997113)
Timeframe: single time point measured after sedation procedure completed
| Intervention | participants (Number) |
|---|---|
| Propofol | 2 |
| Propofol/Alfentanil | 5 |
categorized as a change in end tidal CO2 from baseline >10mmhg, a loss of end tidal CO2 waveform for more than 6 seconds, or an oxygen saturation less than 93%. (NCT00997113)
Timeframe: From one minute prior to the start of the sedation procedure until the patient has returned to baseline mental status
| Intervention | participants (Number) |
|---|---|
| Propofol | 4 |
| Propofol/Alfentanil | 5 |
adverse respiratory events measured using capnography, pulse oximetry, and airway maneuvers performed during the sedation procedure (NCT02404610)
Timeframe: From start of procedure until the patient has returned to baseline mental status after the conclusion of the sedation procedure, an expected average time of 30 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| Moderate Procedural Sedation | 22 |
| Deep Procedural Sedation | 21 |
"Efficacy is defined as:~The patient does not have unpleasant recall of the procedure.~The patient did not experience sedation-related adverse events resulting in abandonment of the procedure or a permanent complication or an unplanned admission to the hospital or prolonged emergency department (ED) observation~The patient did not actively resist or require physical restraint for completion of the procedure. The need for minimal redirection of movements should not be considered as active resistance or physical restraint.~The procedure was successful" (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | participants (Number) |
|---|---|
| Ketamine Alone | 97 |
| Ketamine Co-Administered With Propofol | 81 |
Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | units on a scale (Median) |
|---|---|
| Ketamine Alone | 10 |
| Ketamine Co-Administered With Propofol | 8 |
Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | units on a scale (1-10) (Median) |
|---|---|
| Ketamine Alone | 10 |
| Ketamine Co-Administered With Propofol | 10 |
Measured on a 10-point scale (1= least satisfied, 10= most satisfied) (NCT01387139)
Timeframe: After procedure is completed, on average less than 1 hour
| Intervention | units on a scale (Median) |
|---|---|
| Ketamine Alone | 9 |
| Ketamine Co-Administered With Propofol | 8 |
Time until the patient has a Vancouver Sedation Recovery Scale Score of 18 or greater. (NCT01387139)
Timeframe: Once Vancouver Sedation Recovery Scale Score reaches 18 or greater, on average less than 1 hour
| Intervention | minutes (Median) |
|---|---|
| Ketamine Alone | 44 |
| Ketamine Co-Administered With Propofol | 43.5 |
We will record all adverse events during the sedation, and then perform a follow-up call to determine if any additional adverse events occured after discharge. (NCT01387139)
Timeframe: From enrollment through completion of follow-up, up to 7 days
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Respiratory depression | Cardiovascular event | vomiting/retching | Unpleasant recovery reaction | |
| Ketamine Alone | 12 | 1 | 21 | 4 |
| Ketamine Co-Administered With Propofol | 15 | 0 | 18 | 2 |
2 reviews available for propofol and Bone Fractures
| Article | Year |
|---|---|
Decreasing adverse outcomes of unmodified electroconvulsive therapy: suggestions and possibilities.
Topics: Anesthesia; Anesthetics, Intravenous; Anxiety; Benzodiazepines; Confusion; Depressive Disorder; Deve | 2012 |
Sedation and analgesia for pediatric fracture reduction in the emergency department: a systematic review.
Topics: Analgesics; Child; Drug Combinations; Emergency Service, Hospital; Fentanyl; Fractures, Bone; Humans | 2006 |
6 trials available for propofol and Bone Fractures
| Article | Year |
|---|---|
Randomized clinical trial of the effect of supplemental opioids in procedural sedation with propofol on serum catecholamines.
Topics: Adolescent; Adult; Alfentanil; Analgesics, Opioid; Anesthetics, Combined; Biomarkers; Catecholamines | 2013 |
Ketamine/propofol versus midazolam/fentanyl for procedural sedation and analgesia in the emergency department: a randomized, prospective, double-blind trial.
Topics: Adjuvants, Anesthesia; Adult; Analgesics; Anesthetics, Intravenous; Attitude of Health Personnel; Do | 2011 |
Randomized clinical trial of propofol versus methohexital for procedural sedation during fracture and dislocation reduction in the emergency department.
Topics: Adult; Anesthetics, Intravenous; Conscious Sedation; Emergencies; Fractures, Bone; Humans; Joint Dis | 2003 |
The effect of the assignment of a pre-sedation target level on procedural sedation using propofol.
Topics: Adult; Conscious Sedation; Electroencephalography; Emergency Service, Hospital; Fractures, Bone; Hum | 2007 |
Effect of nitrous oxide and propofol on amino acid metabolism in neoplasic patients.
Topics: Amino Acids; Anesthetics, Inhalation; Anesthetics, Intravenous; Bronchial Neoplasms; Fractures, Bone | 1997 |
Anesthesia with ketamine, propofol, and fentanyl decreases the frequency of postoperative psychosis emergence and confusion in schizophrenic patients.
Topics: Adult; Aged; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, I | 2002 |
13 other studies available for propofol and Bone Fractures
| Article | Year |
|---|---|
Propofol Promotes Ankle Fracture Healing in Children by Inhibiting Inflammatory Response.
Topics: Ankle Joint; Bradykinin; Cell Death; Cell Line, Tumor; Child; Cytokines; Female; Fracture Healing; F | 2018 |
[Video laryngoscopic tracheal intubation under sedation].
Topics: Aged, 80 and over; Braces; Deep Sedation; Female; Femoral Neck Fractures; Fractures, Bone; Glottis; | 2013 |
[Anesthesiology treatment of an "open book" pelvic fracture due to an explosion].
Topics: Adult; Afghan Campaign 2001-; Anesthesia, General; Blast Injuries; Blood Component Transfusion; Etom | 2014 |
Emergency department procedural sedation: the London experience.
Topics: Academic Medical Centers; Adult; Aged; Analgesia; Cohort Studies; Confidence Intervals; Conscious Se | 2015 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol).
Topics: Adolescent; Analgesics; Anesthetics, Intravenous; Ankle Injuries; Child; Child, Preschool; Conscious | 2010 |
Procedural sedation and analgesia in a Canadian ED: a time-in-motion study.
Topics: Alberta; Analgesia; Analgesics, Opioid; Atrial Fibrillation; Conscious Sedation; Drug Therapy, Combi | 2011 |
Propofol-ketamine anesthesia for internal fixation of fractures in racehorses.
Topics: Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Blood Pressur | 2004 |
Capnography and depth of sedation during propofol sedation in children.
Topics: Adolescent; Arm Injuries; Capnography; Child; Conscious Sedation; Emergency Service, Hospital; Fract | 2007 |
Capnography and depth of sedation during propofol sedation in children.
Topics: Adolescent; Arm Injuries; Capnography; Child; Conscious Sedation; Emergency Service, Hospital; Fract | 2007 |
Capnography and depth of sedation during propofol sedation in children.
Topics: Adolescent; Arm Injuries; Capnography; Child; Conscious Sedation; Emergency Service, Hospital; Fract | 2007 |
Capnography and depth of sedation during propofol sedation in children.
Topics: Adolescent; Arm Injuries; Capnography; Child; Conscious Sedation; Emergency Service, Hospital; Fract | 2007 |
Propofol infusion for sedation during spinal anesthesia.
Topics: Adult; Aged; Anesthesia, Spinal; Anesthetics, Intravenous; Female; Fractures, Bone; Humans; Infusion | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department.
Topics: Adolescent; Anesthetics, Combined; Child; Child, Preschool; Deep Sedation; Emergency Service, Hospit | 2007 |
Anesthesia for orthopedic surgery in Pallister-Killian syndrome.
Topics: Abnormalities, Multiple; Alfentanil; Androstanols; Anesthesia; Anesthesia, Epidural; Anesthetics, Co | 2008 |
[Locoregional anesthesia of the lower limb at admission of a polytrauma patient with a leg fracture].
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Fentanyl; Fractures, Bone; Humans; Leg Injuries; | 1998 |
[Anesthetic managements of a patient with multiple sclerosis using propofol].
Topics: Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intravenous; Femal | 1998 |