propofol has been researched along with Body Weight in 113 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the median effective dose (ED50) of prophylactic intravenous lidocaine for the prevention of propofol medium-chain triglyceride/long-chain triglyceride (MCT/LCT) emulsion injection pain." | 9.41 | Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated with Medium- and Long-Chain Triglycerides Based on Lean Body Weight. ( Ma, R; Shan, Q; Sui, W; Tan, C; Tian, S; Xing, Z; Zhang, D; Zhang, Z; Zhou, W, 2021) |
| "Propofol dosing based on total body weight (TBW) can lead to overdosing in morbidly obese (MO) patients." | 9.24 | Optimal propofol induction dose in morbidly obese patients: A randomized controlled trial comparing the bispectral index and lean body weight scalar. ( Chung, F; Riad, W; Subramani, Y; Wong, J, 2017) |
| "Different propofol target concentrations for each PK model must be used for induction when using total body weight in morbidly obese patients." | 9.16 | The effective effect-site propofol concentration for induction and intubation with two pharmacokinetic models in morbidly obese patients using total body weight. ( Bugedo, DA; Cortínez, LI; Donoso, MT; Echevarría, GC; Elgueta, MF; Muñoz, HR, 2012) |
| "Sixty MO subjects (body mass index ≥40 kg/m(2)) were randomized to receive a propofol infusion (100 mg · kg(-1) · h(-1)) for induction of anesthesia based on total body weight (TBW) or lean body weight (LBW)." | 9.15 | Lean body weight scalar for the anesthetic induction dose of propofol in morbidly obese subjects. ( Brodsky, JB; Ingrande, J; Lemmens, HJ, 2011) |
| "Pharmacokinetic studies in obese patients suggest that dosing of rocuronium should be based on ideal body weight (IBW)." | 9.14 | Should dosing of rocuronium in obese patients be based on ideal or corrected body weight? ( Claudius, C; Jenstrup, MT; Lund, J; Meyhoff, CS; Rasmussen, LS; Sørensen, AM; Viby-Mogensen, J, 2009) |
| "We have derived a population PK model using obese and non-obese data to characterize propofol PK over a wide range of body weights." | 9.14 | Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model. ( Anderson, BJ; Cortínez, LI; Holford, NH; Muñoz, HR; Olivares, L; Penna, A; Sepulveda, P; Struys, MM, 2010) |
| " Our primary end-point was to delineate the relationship between propofol dosing and body size descriptors namely body mass index, total body weight, ideal body weight, lean body weight (LBW) and normalized LBW." | 7.91 | Propofol Sedation for Intragastric Balloon Removal: Looking for the Optimal Body Weight Descriptor. ( Fyntanidou, B; Grosomanidis, V; Kotzampassi, K; Papakostas, P; Stavrou, G; Tsaousi, G, 2019) |
| "Infusion rate of propofol during anaesthesia is usually based on total body weight." | 7.70 | Is total body weight an appropriate predictor for propofol maintenance dose? ( Ebina, T; Hirota, K; Ishihara, H; Matsuki, A; Sato, T, 1999) |
| "To determine the median effective dose (ED50) of prophylactic intravenous lidocaine for the prevention of propofol medium-chain triglyceride/long-chain triglyceride (MCT/LCT) emulsion injection pain." | 5.41 | Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated with Medium- and Long-Chain Triglycerides Based on Lean Body Weight. ( Ma, R; Shan, Q; Sui, W; Tan, C; Tian, S; Xing, Z; Zhang, D; Zhang, Z; Zhou, W, 2021) |
| "We conclude that in children with biliary atresia the pharmacokinetics of propofol are similar to those of healthy children." | 5.29 | Propofol pharmacokinetics in children with biliary atresia. ( Raoof, AA; van Obbergh, LJ; Verbeeck, RK, 1995) |
| "Propofol dosing based on total body weight (TBW) can lead to overdosing in morbidly obese (MO) patients." | 5.24 | Optimal propofol induction dose in morbidly obese patients: A randomized controlled trial comparing the bispectral index and lean body weight scalar. ( Chung, F; Riad, W; Subramani, Y; Wong, J, 2017) |
| "The aim of the study is to investigate the efficacy of different dosages of single bolus propofol administered on the basis of total body weight or corrected body weight for the intravenous induction of anesthesia in obese patients undergoing bariatric surgery." | 5.17 | Different dosing regimens for propofol induction in obese patients. ( Kuo, CJ; Lam, F; Lee, YJ; Liao, CC; Lin, CS; Wang, W, 2013) |
| "Given the alarming increase in obesity among children undergoing surgery, the main aim of this study was to characterize propofol clearance in a cohort of morbidly obese children and adolescents in relation to their age and body weight characteristics." | 5.16 | Propofol clearance in morbidly obese children and adolescents: influence of age and body size. ( Chidambaran, V; Cox, SL; Diepstraten, J; Esslinger, HR; Inge, TH; Knibbe, CA; Sadhasivam, S; Vinks, AA, 2012) |
| "Different propofol target concentrations for each PK model must be used for induction when using total body weight in morbidly obese patients." | 5.16 | The effective effect-site propofol concentration for induction and intubation with two pharmacokinetic models in morbidly obese patients using total body weight. ( Bugedo, DA; Cortínez, LI; Donoso, MT; Echevarría, GC; Elgueta, MF; Muñoz, HR, 2012) |
| "Sixty MO subjects (body mass index ≥40 kg/m(2)) were randomized to receive a propofol infusion (100 mg · kg(-1) · h(-1)) for induction of anesthesia based on total body weight (TBW) or lean body weight (LBW)." | 5.15 | Lean body weight scalar for the anesthetic induction dose of propofol in morbidly obese subjects. ( Brodsky, JB; Ingrande, J; Lemmens, HJ, 2011) |
| "7) were randomly allocated to receive propofol target-controlled infusion based on a weight adjustment formula (group adjusted) or without adjustment [group total body weight (TBW)]." | 5.14 | No adjustment vs. adjustment formula as input weight for propofol target-controlled infusion in morbidly obese patients. ( Albertin, A; Aldegheri, G; Ceriani, V; Fermo, I; Khairallah, I; La Colla, G; La Colla, L; Lodi, T; Mangano, A; Porta, A, 2009) |
| "Pharmacokinetic studies in obese patients suggest that dosing of rocuronium should be based on ideal body weight (IBW)." | 5.14 | Should dosing of rocuronium in obese patients be based on ideal or corrected body weight? ( Claudius, C; Jenstrup, MT; Lund, J; Meyhoff, CS; Rasmussen, LS; Sørensen, AM; Viby-Mogensen, J, 2009) |
| "We have derived a population PK model using obese and non-obese data to characterize propofol PK over a wide range of body weights." | 5.14 | Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model. ( Anderson, BJ; Cortínez, LI; Holford, NH; Muñoz, HR; Olivares, L; Penna, A; Sepulveda, P; Struys, MM, 2010) |
| "4 mg/kg body weight (BW), and acepromazine, 0." | 5.09 | The effect of opioid and acepromazine premedication on the anesthetic induction dose of propofol in cats. ( Cantwell, SL; Caulkett, NA; Duke, T; Hall, TL; Townsend, HG, 1999) |
| " Ketamine had no influence on the incidence of apnea after propofol, and the net hemodynamic effects were minimal." | 5.08 | Additive interactions between propofol and ketamine when used for anesthesia induction in female patients. ( Gin, T; Hong, W; Hui, TW; Plummer, J; Short, TG; Suen, T, 1995) |
| " Lean body weight was proposed as a suitable weight scalar for induction of anaesthesia with propofol whereas total body weight for maintenance of anaesthesia with propofol and depolarizing muscle relaxants." | 4.98 | Peri-operative Medication Dosing in Adult Obese Elective Surgical Patients: A Systematic Review of Clinical Studies. ( Curtain, C; Hussain, Z; Mirkazemi, C; Zaidi, STR, 2018) |
| "Twenty morbidly obese and 10 lean subjects were each administered propofol for induction of anesthesia at a rate of 100 mg/kg/h based on lean body weight and total body weight for obese and lean subjects, respectively." | 3.96 | The Performance of an Artificial Neural Network Model in Predicting the Early Distribution Kinetics of Propofol in Morbidly Obese and Lean Subjects. ( Chien, A; Gabriel, RA; Ingrande, J; Krasinska, K; Lemmens, HJM; McAuley, J, 2020) |
| " The outcome was the average infusion rate of propofol, and potential predictor variables were age, sex, body weight, treatment time, and amount of midazolam." | 3.83 | Female Patients Require a Higher Propofol Infusion Rate for Sedation. ( Higuchi, H; Honda, Y; Ishii-Maruhama, M; Maeda, S; Miyawaki, T; Tomoyasu, Y, 2016) |
| "To explore the neuromuscular effects of cisatracurium besylate in morbidly obese patients when dosed according to real body weight under total intravenous anesthesia with propofol." | 3.80 | [Neuromuscular effects of cisatracurium besylate in obese patients]. ( Geng, Z; Wu, X, 2014) |
| " Ten items (age, body weight, sex, duration of general anesthesia, use of propofol, use of sevoflurane, use of nitrous oxide, use of neostigmine, treatment accompanied with bleeding, and transfusion volume) were selected as risk factors for PONV." | 3.77 | Risk factors for nausea and vomiting after day care general anesthesia in mentally challenged patients undergoing dental treatment. ( Ichinohe, T; Kaneko, Y; Miyata, M; Nakata, E; Yumura, J, 2011) |
| " Body weight was a significant covariate for V(1) of both formulations and sex for k(21) of microemulsion propofol." | 3.75 | Pharmacokinetics and pharmacodynamics of a new reformulated microemulsion and the long-chain triglyceride emulsion of propofol in beagle dogs. ( Choi, BM; Choi, HG; Ghim, JL; Lee, EK; Lee, HM; Lee, SH; Noh, GJ; Roh, YJ; Song, MH, 2009) |
| " The mice displayed increased anxiety-like behaviour in several tests including elevated plus-maze and were more susceptible to pentylenetetrazole-induced seizures." | 3.73 | Behavioural phenotypes of hypomorphic KCC2-deficient mice. ( Airaksinen, MS; Rauvala, H; Savilahti, H; Tornberg, J; Voikar, V, 2005) |
| " The aim of this work was to study the relationship between various pharmacokinetic parameters for propofol and body weight using data from rats, children and adults." | 3.73 | Allometric relationships between the pharmacokinetics of propofol in rats, children and adults. ( Aarts, LP; Danhof, M; Knibbe, CA; Kuks, PF; Zuideveld, KP, 2005) |
| "25 mg of propofol (range 10 mg to 356 mg); in relation to body weight, the mean was 2." | 3.72 | Propofol intravenous conscious sedation for anxious children in a specialist paediatric dentistry unit. ( Carruthers, M; Gilchrist, F; Hosey, MT; Jones, RM; Makin, A, 2004) |
| "To analyze population pharmacokinetics of propofol in Chinese surgical patients using a nonlinear mixed-effect model (NONMEM) program and to quantitate the effects of covariance of gender, age, and body weight." | 3.72 | Population pharmacokinetics of propofol in Chinese patients. ( Fu, SE; Hu, SY; Li, YH; Liu, FK; Rui, JZ; Wang, LQ; Wen, Q; Xu, JG; Yang, JJ; Zhou, YG, 2003) |
| "Infusion rate of propofol during anaesthesia is usually based on total body weight." | 3.70 | Is total body weight an appropriate predictor for propofol maintenance dose? ( Ebina, T; Hirota, K; Ishihara, H; Matsuki, A; Sato, T, 1999) |
| "Target-controlled infusion (TCI) systems incorporating pharmacokinetic (PK) or PK-pharmacodynamic (PK-PD) models can be used to facilitate drug administration." | 3.01 | Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia. ( Absalom, AR; Eleveld, DJ; Hannivoort, LN; Introna, M; Struys, MMRF; Touw, DJ; Vellinga, R, 2021) |
| "The modified Marsh and Schnider pharmacokinetic models for propofol consistently produce negatively and positively biased predictions in underweight patients, respectively." | 2.87 | Population pharmacokinetic analysis of propofol in underweight patients under general anaesthesia. ( Choi, BM; Choi, SM; Lee, EK; Lee, KH; Noh, GJ; Park, JH; Yun, HJ, 2018) |
| "acetaminophen was administered over 15, 60, or 120 min." | 2.84 | Population pharmacokinetics of intravenous acetaminophen in Japanese patients undergoing elective surgery. ( Hasegawa, M; Imaizumi, T; Iseki, Y; Mogami, M; Murakawa, M; Obara, S, 2017) |
| " Adjusting for weight and sex further improved the propofol pharmacokinetic model." | 2.82 | Epidural Blockade Affects the Pharmacokinetics of Propofol in Surgical Patients. ( Dahan, A; Lesman, A; Olofsen, E; Sitsen, E; Vuyk, J, 2016) |
| "The amount of propofol-remifentanil administered by the controller is consistent with current knowledge, propofol is best dosed using TBW whereas remifentanil is best dosed using IBW." | 2.80 | Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison. ( Assenzo, V; Chazot, T; Cocard, V; Fischler, M; Journois, D; Le Guen, M; Liu, N; Lory, C; Sessler, DI, 2015) |
| "In view of the increasing prevalence of morbidly obese patients, the influence of excessive total bodyweight (TBW) on the pharmacokinetics and pharmacodynamics of propofol was characterized in this study using bispectral index (BIS) values as a pharmacodynamic endpoint." | 2.76 | Population pharmacokinetics and pharmacodynamics of propofol in morbidly obese patients. ( Danhof, M; Deneer, VH; Diepstraten, J; Knibbe, CA; Peeters, MY; van Dongen, EP; van Kralingen, S; van Ramshorst, B; Wiezer, RJ, 2011) |
| " In conclusion, the duration of action of cisatracurium was prolonged in morbidly obese patients when dosed according to RBW compared with a control group of normal weight patients." | 2.71 | The effects of cisatracurium on morbidly obese women. ( Gullo, A; Leykin, Y; Lomangino, G; Lucca, M; Marzano, B; Pellis, T, 2004) |
| " Population pharmacokinetic modeling was performed using NONMEM (NONMEM Project Group, University of California, San Francisco, CA)." | 2.69 | Population pharmacokinetics of propofol: a multicenter study. ( Ihmsen, H; Schüttler, J, 2000) |
| "The influence of infusion rate on the induction dose-response relation has not been investigated over a wide range of infusion rates." | 2.69 | Investigation of effective anesthesia induction doses using a wide range of infusion rates with undiluted and diluted propofol. ( Ikeda, K; Ikeda, T; Kazama, T; Kikura, M; Kurita, T; Morita, K; Sato, S, 2000) |
| "Midazolam was associated with impairment of performance on the TDT and DSST after premedication administration and 15 (TDT and DSST) and 30 (DSST) min after postanesthesia care unit (PACU) arrival." | 2.68 | Midazolam premedication increases sedation but does not prolong discharge times after brief outpatient general anesthesia for laparoscopic tubal sterilization. ( Hussain, A; Richardson, MG; Wu, CL, 1997) |
| "The use of conventional pharmacokinetic parameters sets 'models' derived from nonobese patients has proven inadequate to administer intravenous anesthetics in the obese population and is commonly associated with higher than anticipated plasma propofol concentrations when used with target (plasma or effect site) controlled infusion pumps." | 2.58 | Advances in pharmacokinetic modeling: target controlled infusions in the obese. ( Anderson, BJ; Cortínez, LI, 2018) |
| "Therapeutic endoscopy of early gastric cancers can often be performed with only moderate sedation." | 2.50 | Propofol sedation during endoscopic treatment for early gastric cancer compared to midazolam. ( Kiriyama, S; Kuwano, H; Naitoh, H, 2014) |
| "Propofol maturation has been described with a mature clearance of 1." | 2.46 | Pediatric models for adult target-controlled infusion pumps. ( Anderson, BJ, 2010) |
| "The recently introduced open-target-controlled infusion (TCI) systems can be programmed with any pharmacokinetic model, and allow either plasma- or effect-site targeting." | 2.45 | Pharmacokinetic models for propofol--defining and illuminating the devil in the detail. ( Absalom, AR; De Smet, T; Mani, V; Struys, MM, 2009) |
| "This study aimed to establish a population pharmacokinetic and pharmacodynamic (PK-PD) model to explore the optimal maintenance dose and appropriate starting time of maintenance dose after induction of ciprofol and investigate the efficacy and safety of ciprofol for general anesthesia induction and maintenance in patients undergoing elective surgery." | 2.44 | Population pharmacokinetic/pharmacodynamic modeling and exposure-response analysis of ciprofol in the induction and maintenance of general anesthesia in patients undergoing elective surgery: A prospective dose optimization study. ( Chen, M; Hu, M; Liu, L; Liu, X; Wang, K; Wu, N; Xiang, X; Yan, P; Yang, Y, 2024) |
| "There were 103 patients with cancer (mean age 59." | 1.72 | Propofol doses differ in total intravenous anaesthesia (TIVA) for cancer and no cancer surgery - observational cohort study. ( Pejakov, L; Ždralević, M; Đurišić, I, 2022) |
| "Develop a population pharmacokinetic model describing propofol pharmacokinetics in (pre)term neonates and infants, that can be used for precision dosing (e." | 1.62 | Population pharmacokinetics of propofol in neonates and infants: Gestational and postnatal age to determine clearance maturation. ( Allegaert, K; Annaert, P; Bouillon, T; Nicolaï, J; Sandra, L; Smits, A, 2021) |
| " Guiding propofol induction dose according to baseline frailty score should also be considered to estimate individualized dosage profiles." | 1.51 | Bioelectrical impedance analysis of body composition for the anesthetic induction dose of propofol in older patients. ( Araújo, AM; Falcão, AC; Machado, HS; Soares-da-Silva, P, 2019) |
| "For propofol, there was a significantly lower dosing for older patients: 17% for patients aged 65-79 and 29% for those aged >80, which was still in less than the recommendations." | 1.43 | Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice. ( Akhtar, S; Burg, MM; Dai, F; Heng, J; Liu, J; Schonberger, RB, 2016) |
| "Obesity is associated with important physiologic changes that can potentially affect the pharmacokinetic (PK) and pharmacodynamic (PD) profile of anesthetic drugs." | 1.40 | Performance of propofol target-controlled infusion models in the obese: pharmacokinetic and pharmacodynamic analysis. ( Cortínez, LI; Crovari, F; De la Fuente, N; Eleveld, DJ; Ibacache, M; Oliveros, A; Sepulveda, P; Solari, S, 2014) |
| "Body weight was a significant covariate for the CL1 and V1." | 1.39 | Bispectral index dynamics during propofol hypnosis is similar in red-haired and dark-haired subjects. ( Akca, O; Doufas, AG; Komatsu, R; Lauber, R; Orhan-Sungur, M; Sessler, DI; Shafer, SL, 2013) |
| "Uncertainty exists as to the most suitable pharmacokinetic parameter sets for propofol target-controlled infusions (TCI)." | 1.38 | Allometric or lean body mass scaling of propofol pharmacokinetics: towards simplifying parameter sets for target-controlled infusions. ( Coetzee, JF, 2012) |
| "In order to successfully develop the effective population pharmacokinetic model to predict the concentration of propofol administrated intravenously, the data including the concentrations across both distribution and elimination phases from five hospitals were analyzed using nonlinear mixed effect model (NONMEM)." | 1.36 | [Population pharmacokinetic modeling and evaluation of propofol from multiple centers]. ( Chen, WY; Chi, XJ; Li, JH; Rui, JZ; Xu, JG; Ye, HB; Zhang, XA; Zheng, H, 2010) |
| " The median percentage error of the predictions was calculated using the equation %error = (CL(allometric) - CL(i))/CL(i) x 100, where CL(allometric) is the predicted propofol clearance from the allometric equations for each individual and CL(i) is the individual-predicted (post hoc) propofol clearance value derived from published population pharmacokinetic models." | 1.36 | Prediction of propofol clearance in children from an allometric model developed in rats, children and adults versus a 0.75 fixed-exponent allometric model. ( Allegaert, K; Blussé van Oud-Alblas, HJ; Cella, M; Danhof, M; Knibbe, CA; Peeters, MY; Tibboel, D, 2010) |
| "To develop a predictive pharmacokinetic model for propofol that could inform development of a dosing strategy for the obese population." | 1.35 | Encouraging the move towards predictive population models for the obese using propofol as a motivating example. ( Green, B; Kirkpatrick, CM; McLeay, SC; Morrish, GA, 2009) |
| "/st> Propofol clearance is lower in neonates than in adults and displays extensive interindividual variability, in part explained by postmenstrual age (PMA) and postnatal age (PNA)." | 1.35 | Urinary propofol metabolites in early life after single intravenous bolus. ( Allegaert, K; Cossey, V; de Hoon, J; Naulaers, G; Rayyan, M; Vancraeynest, J; Verbesselt, R, 2008) |
| "The propofol infusion was titrated using State Entropy as a pharmacodynamic endpoint and remifentanil infused, using a modified up-and-down method, with respiratory rate depression as a pharmacodynamic endpoint." | 1.34 | Relationship between age and spontaneous ventilation during intravenous anesthesia in children. ( Amari, E; Ansermino, JM; Barker, N; Lim, J; Malherbe, S, 2007) |
| "Newly collected observations following intravenous bolus administration of propofol in preterm and term neonates (n = 9) were compared with earlier reported pharmacokinetic estimates in toddlers and young children." | 1.34 | Maturational pharmacokinetics of single intravenous bolus of propofol. ( Allegaert, K; de Hoon, J; Murat, I; Naulaers, G; Verbesselt, R, 2007) |
| "For propofol, weight was corrected as suggested by Servin and colleagues." | 1.34 | Predictive performance of 'Servin's formula' during BIS-guided propofol-remifentanil target-controlled infusion in morbidly obese patients. ( Albertin, A; Bergonzi, PC; Dedola, E; Fermo, I; Gonfalini, M; La Colla, G; La Colla, L; Pasculli, N; Poli, D; Turi, S, 2007) |
| "There is no information about the pharmacokinetic profile of propofol in Chinese children younger than 3 yr." | 1.33 | Pharmacokinetics of a single bolus of propofol in chinese children of different ages. ( Aarons, L; Chen, X; Freemantle, N; Lian, Q; Matthews, I; Shangguan, WN; Smith, FG; Wang, Z, 2006) |
| "To determine propofol concentration in the cerebral spinal fluid (CSF) of neurosurgical patients and carry out a preliminary population pharmacodynamic study." | 1.33 | Influence of age and sex on pharmacodynamics of propofol in neurosurgical patients: model development. ( Li, YH; Wu, FS; Xu, JG, 2006) |
| "Propofol infusion rate was determined using the corrected body weight drawn by Servin et al." | 1.31 | [Anesthetic management of a morbidly obese patient undergoing laparoscopic gastric bypass surgery]. ( Anbe, A; Hirabayashi, Y; Horikawa, Y; Saitoh, K; Seo, N, 2001) |
| " To increase our insight into the pharmacokinetics of propofol in this patient population and to obtain pharmacokinetic parameters applicable in target controlled infusion (TCI), the pharmacokinetics of propofol during and after continuous infusion were studied in 31 ASA class 1 and 2 patients, aged 65-91 yr, scheduled for general surgery." | 1.31 | Gender differences in the pharmacokinetics of propofol in elderly patients during and after continuous infusion. ( Bovill, JG; Burm, AG; Oostwouder, CJ; Vletter, AA; Vuyk, J, 2001) |
| "We conclude that in children with biliary atresia the pharmacokinetics of propofol are similar to those of healthy children." | 1.29 | Propofol pharmacokinetics in children with biliary atresia. ( Raoof, AA; van Obbergh, LJ; Verbeeck, RK, 1995) |
| "Atracurium was infused for the first 1 h to maintain a target steady state plasma concentration of 1." | 1.28 | Pharmacokinetics of atracurium during continuous infusion. ( Beemer, GH; Bjorksten, AR; Crankshaw, DP, 1990) |
| " Maintenance dosage of propofol sufficient to abolish movement decreased with increasing age (p less than 0." | 1.27 | Intravenous anaesthesia with propofol and alfentanil. The influence of age and weight. ( Dev, VJ; Hilton, P; Major, E, 1986) |
| "Propofol was extensively bound (mean: 97-98%) to the plasma protein of both cirrhotic and control groups." | 1.27 | Pharmacokinetics and protein binding of propofol in patients with cirrhosis. ( Cockshott, ID; Desmonts, JM; Farinotti, R; Haberer, JP; Plummer, GF; Servin, F, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.77) | 18.7374 |
| 1990's | 15 (13.27) | 18.2507 |
| 2000's | 37 (32.74) | 29.6817 |
| 2010's | 52 (46.02) | 24.3611 |
| 2020's | 7 (6.19) | 2.80 |
| Authors | Studies |
|---|---|
| Pejakov, L | 1 |
| Ždralević, M | 1 |
| Đurišić, I | 1 |
| Liu, L | 1 |
| Wang, K | 1 |
| Yang, Y | 1 |
| Hu, M | 1 |
| Chen, M | 1 |
| Liu, X | 1 |
| Yan, P | 1 |
| Wu, N | 1 |
| Xiang, X | 1 |
| Araújo, AM | 1 |
| Machado, HS | 1 |
| Falcão, AC | 1 |
| Soares-da-Silva, P | 1 |
| Ingrande, J | 2 |
| Gabriel, RA | 1 |
| McAuley, J | 1 |
| Krasinska, K | 1 |
| Chien, A | 1 |
| Lemmens, HJM | 1 |
| Sandra, L | 1 |
| Smits, A | 1 |
| Allegaert, K | 6 |
| Nicolaï, J | 1 |
| Annaert, P | 1 |
| Bouillon, T | 1 |
| Tian, S | 1 |
| Zhang, D | 1 |
| Zhou, W | 1 |
| Tan, C | 1 |
| Shan, Q | 1 |
| Ma, R | 1 |
| Xing, Z | 1 |
| Sui, W | 1 |
| Zhang, Z | 1 |
| Vellinga, R | 1 |
| Hannivoort, LN | 1 |
| Introna, M | 1 |
| Touw, DJ | 1 |
| Absalom, AR | 2 |
| Eleveld, DJ | 2 |
| Struys, MMRF | 1 |
| Zhang, N | 1 |
| Liao, Z | 1 |
| Wu, P | 1 |
| Fang, H | 1 |
| Cai, G | 1 |
| Imaizumi, T | 1 |
| Obara, S | 1 |
| Mogami, M | 1 |
| Iseki, Y | 1 |
| Hasegawa, M | 1 |
| Murakawa, M | 1 |
| Cortínez, LI | 6 |
| Sepúlveda, P | 3 |
| Rolle, A | 1 |
| Cottin, P | 1 |
| Guerrini, A | 1 |
| Anderson, BJ | 5 |
| Hussain, Z | 1 |
| Curtain, C | 1 |
| Mirkazemi, C | 1 |
| Zaidi, STR | 1 |
| Wu, Z | 1 |
| Li, J | 1 |
| Wang, C | 2 |
| Yang, J | 1 |
| Chen, X | 2 |
| Yang, W | 1 |
| Xiong, Z | 1 |
| Peng, X | 1 |
| Park, JH | 2 |
| Choi, SM | 1 |
| Lee, KH | 1 |
| Yun, HJ | 1 |
| Lee, EK | 2 |
| Choi, BM | 2 |
| Noh, GJ | 2 |
| Tsaousi, G | 1 |
| Fyntanidou, B | 1 |
| Stavrou, G | 1 |
| Papakostas, P | 1 |
| Kotzampassi, K | 1 |
| Grosomanidis, V | 1 |
| Posner, LP | 1 |
| Willcox, JL | 1 |
| Suter, SE | 1 |
| Fang, M | 1 |
| Tao, Y | 1 |
| Wang, Y | 1 |
| de la Fuente, NF | 1 |
| Puga, VA | 1 |
| Muñoz, HR | 3 |
| Glen, JB | 2 |
| Lam, F | 1 |
| Liao, CC | 1 |
| Lee, YJ | 1 |
| Wang, W | 1 |
| Kuo, CJ | 1 |
| Lin, CS | 1 |
| Nath, SS | 1 |
| Tripathi, M | 1 |
| Banerjee, S | 1 |
| De la Fuente, N | 1 |
| Oliveros, A | 1 |
| Crovari, F | 1 |
| Ibacache, M | 1 |
| Solari, S | 1 |
| Kiriyama, S | 1 |
| Naitoh, H | 1 |
| Kuwano, H | 1 |
| Baijal, RG | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Modelling Propofol Pharmacokinetics and Pharmacodynamics During an Intravenous Anaesthesia Guided by the Bispectral Index (BIS)[NCT02713698] | 60 participants (Actual) | Observational | 2016-04-01 | Completed | |||
| A High Resolution Pharmacokinetic/Pharmacodynamic Model of Propofol in Morbidly Obese Subjects[NCT01591148] | Phase 1 | 30 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| Propofol Effect-Site Target Controlled Infusion in the Obese: Characterization of the Time Profile of Bispectral Index Response.[NCT01665079] | Phase 4 | 14 participants (Actual) | Interventional | 2011-04-30 | Completed | ||
| Development of Pharmacokinetic / Pharmacodynamic (pk/pd) Model of Propofol in Patients With Severe Burns[NCT03704285] | 15 participants (Actual) | Observational | 2018-09-29 | Terminated (stopped due to Outbreak COVID 19) | |||
| Validation of a Pharmacokinetic Pharmacodynamic Model to Administer Propofol in Obese Patients[NCT01596387] | Phase 4 | 20 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| Impact of the Automated Administration of Intravenous Anesthesia Compared to Inhalatory Anesthesia on the Speed of Emergence and the Occurrence of Postoperative Delirium[NCT03705728] | 1,000 participants (Anticipated) | Interventional | 2018-05-30 | Recruiting | |||
| Incidence of Early Postoperative Cognitive Dysfunction After Closed Loop Anesthesia vs Inhalational Anesthesia or TIVA[NCT02656901] | 132 participants (Actual) | Interventional | 2016-01-31 | Completed | |||
| Intravenous Anesthesia in Obese Patients: Propofol and Remifentanil Requirements[NCT00779844] | Phase 4 | 63 participants (Actual) | Interventional | 2008-12-31 | Terminated (stopped due to difficulty in recruiting) | ||
| A Phase IV Study to Investigate the Effects of Varied Remifentanil Concentrations on Propofol Requirements for Loss of Consciousness, Response to Painful Stimuli, Bispectral Index and Associated Haemodynamic Changes[NCT02287181] | Phase 4 | 100 participants (Actual) | Interventional | 2015-02-28 | Completed | ||
| Pharmacodynamic Trial on Rocuronium in Obese Patients[NCT00540085] | Phase 4 | 51 participants (Actual) | Interventional | 2007-10-31 | Completed | ||
| Population Pharmacokinetics and Pharmacodynamics of Propofol in the Morbidly Obese Patient[NCT00395681] | Phase 4 | 20 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| A Prospective, Randomized Comparison of Depth of Sedation With Propofol Titrated by Probability Ramp Control to Control by Anesthesia Providers During Esophagogastroduodenoscopy (EGD)[NCT01838304] | 40 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| A Non-Interventional Study to Develop a Pharmacokinetic - Pharmacodynamic Model for Individualized Propofol Dosing[NCT00948597] | 26 participants (Actual) | Observational | 2009-07-31 | Completed | |||
| Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Research Project[NCT00474318] | 250 participants (Actual) | Observational | 2007-03-31 | Active, not recruiting | |||
| Shortening of the Twitch Stabilization Period by Tetanic Stimulation in Acceleromyography in Children and Young Adults[NCT02552875] | Phase 4 | 80 participants (Actual) | Interventional | 2014-09-30 | Completed | ||
| The Effects of Propofol Based Intravenous vs Sevoflurane Inhalation Anaesthesia on Inflammation and Circulating Tumor Cells in Paediatric Tumor Surgery - a Pilot Study[NCT04475705] | Phase 4 | 100 participants (Anticipated) | Interventional | 2021-01-11 | Recruiting | ||
| A Randomized, Open-label Study to Compare Propofol Anesthesia With Sevoflurane Anesthesia in Terms of Overall Survival in Patients With Surgical Intervention for Either Breast-, Colon- or Rectal Cancer[NCT01975064] | Phase 4 | 5,774 participants (Actual) | Interventional | 2013-11-30 | Completed | ||
| Effect of Gender on the Pharmacokinetics-pharmacodynamics of Propofol and Cisatracurium Besylate[NCT02588118] | 120 participants (Actual) | Observational | 2010-01-31 | Completed | |||
| Haemodynamic Stability During Induction of General Anesthesia With Propofol and Remifentanil: A Randomized, Controlled, Double-blind Study Comparing Low vs High Propofol Doses.[NCT03861364] | Phase 4 | 68 participants (Actual) | Interventional | 2019-09-03 | Completed | ||
| "Haemodynamic Stability During Induction of General Anesthesia With Propofol and Remifentanil: A Randomized, Controlled, Double-blind Study Comparing Equipotent Prophylactic Doses of Ephedrine, Phenylephrine, Norepinephrine vs Placebo."[NCT03864094] | Phase 4 | 99 participants (Anticipated) | Interventional | 2022-03-15 | Recruiting | ||
| "Hemodynamic Stability During Induction of General Anesthesia With Propofol and Remifentanil: A Randomized, Controlled, Double-blind Study Comparing Medium and Low Remifentanil Doses."[NCT03861377] | Phase 4 | 99 participants (Actual) | Interventional | 2020-06-09 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Arterial blood samples were obtained after LOC and every 20-30 minutes during propofol infusion. After stopping propofol infusion, arterial blood samples were obtained immediately after recovery of consciousness.~At the end of the surgery arterial blood samples were centrifuged at 2862xg for 5 minutes and they were preserved at -80ºC until analysis.~The quantification of propofol in serum was performed using gas chromatography/ion trap-mass spectrometry (GC/IT-MS)" (NCT02713698)
Timeframe: up to 2 hours
| Intervention | mcg/mL (Mean) |
|---|---|
| Group 1 (≥18 Years, BMI<35kg/m2) | 2.36 |
| Group 2 (≥18 Years, BMI≥35kg/m2) | 3.12 |
| Group 3 (≥65 Years) | 2.91 |
Minute ventilation as determined by respiratory inductance plethysmography from initiation of sedation until emergence. (NCT01838304)
Timeframe: Duration of sedation (average of 25 minutes)
| Intervention | percentage of baseline (Median) |
|---|---|
| Monitoring | 25 |
| Probability Ramp Control | 50 |
Following initial sedation, an infusion rate for propofol is determined by the CRNA (control) or software (experimental). If this rate is appropriate for the duration of the brief procedure, no adjustment to the rate will be required. A greater requirement for rate changes suggests that the anesthesia provider needs to be immediately available to perform these adjustments. (NCT01838304)
Timeframe: Intraprocedure (average of 9 minutes)
| Intervention | Participants (Count of Participants) |
|---|---|
| Monitoring | 16 |
| Probability Ramp Control | 2 |
Time from endoscopic intubation until completion of the procedure. This is not really an outcome measure, but is used to assess balance between groups. (NCT01838304)
Timeframe: Procedure time (average of 9 minutes)
| Intervention | minutes (Mean) |
|---|---|
| Monitoring | 9.03 |
| Probability Ramp Control | 8.9 |
Number of seconds spent below saturation of 80%, reported as the total per group (NCT01838304)
Timeframe: Duration of sedation (mean 25 minutes)
| Intervention | seconds (Count of Units) |
|---|---|
| Monitoring | 168 |
| Probability Ramp Control | 22 |
8 reviews available for propofol and Body Weight
| Article | Year |
|---|---|
Advances in pharmacokinetic modeling: target controlled infusions in the obese.
Topics: Anesthetics, Intravenous; Body Composition; Body Mass Index; Body Weight; Humans; Obesity; Patient-S | 2018 |
Peri-operative Medication Dosing in Adult Obese Elective Surgical Patients: A Systematic Review of Clinical Studies.
Topics: Analgesics; Anticoagulants; Body Mass Index; Body Weight; Clinical Trials as Topic; Elective Surgica | 2018 |
Propofol sedation during endoscopic treatment for early gastric cancer compared to midazolam.
Topics: Body Weight; Conscious Sedation; Dissection; Drug Dosage Calculations; Gastroscopy; Humans; Hypnotic | 2014 |
Pharmacokinetic models for propofol--defining and illuminating the devil in the detail.
Topics: Anesthetics, Intravenous; Body Height; Body Weight; Drug Delivery Systems; Drug Therapy, Computer-As | 2009 |
Pediatric models for adult target-controlled infusion pumps.
Topics: Adolescent; Age Factors; Algorithms; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intra | 2010 |
Overview of total intravenous anesthesia in children.
Topics: Adolescent; Age Factors; Algorithms; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intra | 2010 |
Propofol and children--what we know and what we do not know.
Topics: Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Weight; Child; Consciousness Mon | 2011 |
The use of propofol infusions in paediatric anaesthesia: a practical guide.
Topics: Adult; Age Factors; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Constitution | 1999 |
33 trials available for propofol and Body Weight
| Article | Year |
|---|---|
Median Effective Dose of Lidocaine for the Prevention of Pain Caused by the Injection of Propofol Formulated with Medium- and Long-Chain Triglycerides Based on Lean Body Weight.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Body Weight; Double-Blind Method; Humans; Lidocaine; P | 2021 |
Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia.
Topics: Adolescent; Adult; Age Factors; Aged; Anesthesia, General; Anesthetics, Intravenous; Body Weight; Ch | 2021 |
Population pharmacokinetics of intravenous acetaminophen in Japanese patients undergoing elective surgery.
Topics: Acetaminophen; Administration, Intravenous; Adult; Aged; Anesthesia, General; Body Weight; Elective | 2017 |
Characterization of cardiovascular depression effect for propofol during anesthesia induction period on morbidly obese patients.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Blood Pressure; Body Mass Index; Body Weight; Cardiac O | 2018 |
Population pharmacokinetic analysis of propofol in underweight patients under general anaesthesia.
Topics: Adult; Aged; Anesthesia, General; Anesthetics, Intravenous; Body Mass Index; Body Weight; Drug Admin | 2018 |
Different dosing regimens for propofol induction in obese patients.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Body Weight; Electroencephalography; Female; Hemodynami | 2013 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Feasibility of closed-loop co-administration of propofol and remifentanil guided by the bispectral index in obese patients: a prospective cohort comparison.
Topics: Adult; Anesthesia, General; Body Weight; Cohort Studies; Drug Combinations; Electroencephalography; | 2015 |
Epidural Blockade Affects the Pharmacokinetics of Propofol in Surgical Patients.
Topics: Adult; Amides; Analgesia, Epidural; Anesthetics, Intravenous; Anesthetics, Local; Body Weight; Dose- | 2016 |
Optimal propofol induction dose in morbidly obese patients: A randomized controlled trial comparing the bispectral index and lean body weight scalar.
Topics: Adult; Anesthetics, Intravenous; Body Weight; Consciousness Monitors; Dose-Response Relationship, Dr | 2017 |
No adjustment vs. adjustment formula as input weight for propofol target-controlled infusion in morbidly obese patients.
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Weight; Dose-Response Relationship, D | 2009 |
Should dosing of rocuronium in obese patients be based on ideal or corrected body weight?
Topics: Adult; Androstanols; Anesthesia Recovery Period; Anesthetics, Intravenous; Body Mass Index; Body Wei | 2009 |
Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, Intravenous; Anthropometry; Bariatric Surgery; Body Mas | 2010 |
Lean body weight scalar for the anesthetic induction dose of propofol in morbidly obese subjects.
Topics: Adult; Anesthesia, Intravenous; Body Mass Index; Body Weight; Dose-Response Relationship, Drug; Fema | 2011 |
Population pharmacokinetics and pharmacodynamics of propofol in morbidly obese patients.
Topics: Anesthetics, Intravenous; Body Mass Index; Body Weight; Consciousness Monitors; Female; Humans; Male | 2011 |
The effects of cognitive impairment on anaesthetic requirement in the elderly.
Topics: Aged; Anesthesia; Anesthesia Recovery Period; Anesthesiology; Anesthetics, Inhalation; Body Weight; | 2012 |
Propofol clearance in morbidly obese children and adolescents: influence of age and body size.
Topics: Adolescent; Age Factors; Anesthetics, Intravenous; Body Weight; Child; Dose-Response Relationship, D | 2012 |
Propofol clearance in morbidly obese children and adolescents: influence of age and body size.
Topics: Adolescent; Age Factors; Anesthetics, Intravenous; Body Weight; Child; Dose-Response Relationship, D | 2012 |
Propofol clearance in morbidly obese children and adolescents: influence of age and body size.
Topics: Adolescent; Age Factors; Anesthetics, Intravenous; Body Weight; Child; Dose-Response Relationship, D | 2012 |
Propofol clearance in morbidly obese children and adolescents: influence of age and body size.
Topics: Adolescent; Age Factors; Anesthetics, Intravenous; Body Weight; Child; Dose-Response Relationship, D | 2012 |
The effective effect-site propofol concentration for induction and intubation with two pharmacokinetic models in morbidly obese patients using total body weight.
Topics: Adult; Body Weight; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Intubation, In | 2012 |
Living-donor nephrectomy under combined spinal-epidural anesthesia.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Spinal; Body Weight; Diazepam; Humans; Living Donors; Middl | 2002 |
Acupressure wristbands for the prevention of postoperative nausea and vomiting in adults undergoing cardiac surgery.
Topics: Acupressure; Age Factors; Analgesics, Opioid; Antiemetics; Body Weight; Cardiac Surgical Procedures; | 2004 |
Comparative benefit of preemptively applied thiopental for propofol injection pain: the advantage over lidocaine.
Topics: Adult; Aged; Anesthetics, Intravenous; Anesthetics, Local; Body Weight; Dose-Response Relationship, | 2004 |
The effects of cisatracurium on morbidly obese women.
Topics: Adult; Anesthesia, General; Anesthetics, Intravenous; Atracurium; Body Mass Index; Body Weight; Cali | 2004 |
Effects of short-term propofol administration on pancreatic enzymes and triglyceride levels in children.
Topics: Adolescent; Amylases; Anesthetics, Intravenous; Body Weight; Child; Child, Preschool; Conscious Seda | 2005 |
Propofol administered by a manual infusion regimen.
Topics: Adolescent; Adult; Anesthesia, General; Blood Pressure; Body Weight; Dose-Response Relationship, Dru | 1995 |
Additive interactions between propofol and ketamine when used for anesthesia induction in female patients.
Topics: Adult; Age Factors; Anesthesia, Intravenous; Apnea; Blood Pressure; Body Weight; Dose-Response Relat | 1995 |
Midazolam premedication increases sedation but does not prolong discharge times after brief outpatient general anesthesia for laparoscopic tubal sterilization.
Topics: Adult; Age Factors; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia Recovery Period; | 1997 |
In vivo quantification of muscle damage in dogs after general anaesthesia with halothane and propofol.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Body Weight; Creati | 1997 |
The safety of patient-controlled sedation.
Topics: Adolescent; Adult; Age Factors; Analgesia, Patient-Controlled; Anesthetics, Intravenous; Blood Press | 1997 |
Patient-controlled sedation during transvaginal oocyte retrieval: an assessment of patient acceptance of patient-controlled sedation using a mixture of propofol and alfentanil.
Topics: Adult; Alfentanil; Anesthetics, Combined; Anesthetics, Intravenous; Body Weight; Female; Humans; Hyp | 1998 |
[Economical benefit of continuous total intravenous anesthesia].
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthesia Recovery Period; Anesthesia, Gen | 1999 |
The effect of opioid and acepromazine premedication on the anesthetic induction dose of propofol in cats.
Topics: Acepromazine; Age Factors; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; An | 1999 |
Population pharmacokinetics of propofol: a multicenter study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Algorithms; Anesthetics, Intravenous; Body Weight | 2000 |
Investigation of effective anesthesia induction doses using a wide range of infusion rates with undiluted and diluted propofol.
Topics: Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Weight; Female; Hemodynamics; Humans; | 2000 |
A single sub-anaesthetic dose of propofol to reduce patient recall of peribulbar block.
Topics: Age Factors; Aged; Anesthetics, Intravenous; Anesthetics, Local; Body Weight; Bupivacaine; Cataract | 2000 |
72 other studies available for propofol and Body Weight
| Article | Year |
|---|---|
Propofol doses differ in total intravenous anaesthesia (TIVA) for cancer and no cancer surgery - observational cohort study.
Topics: Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Weight; Cohort Studies; | 2022 |
Population pharmacokinetic/pharmacodynamic modeling and exposure-response analysis of ciprofol in the induction and maintenance of general anesthesia in patients undergoing elective surgery: A prospective dose optimization study.
Topics: Anesthesia, General; Anesthetics, Intravenous; Body Weight; Humans; Infusions, Parenteral; Propofol; | 2024 |
Bioelectrical impedance analysis of body composition for the anesthetic induction dose of propofol in older patients.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthetics, Intravenous; Body Composition; | 2019 |
The Performance of an Artificial Neural Network Model in Predicting the Early Distribution Kinetics of Propofol in Morbidly Obese and Lean Subjects.
Topics: Adult; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Circulation; Body Compos | 2020 |
Population pharmacokinetics of propofol in neonates and infants: Gestational and postnatal age to determine clearance maturation.
Topics: Adult; Body Weight; Female; Gestational Age; Humans; Infant; Infant, Newborn; Metabolic Clearance Ra | 2021 |
Hypermethylation of EFEMP1 in the Hippocampus May Be Related to the Deficit in Spatial Memory of Rat Neonates Triggered by Repeated Administration of Propofol.
Topics: Animals; Animals, Newborn; Body Weight; CpG Islands; Disease Models, Animal; DNA Methylation; Epigen | 2020 |
Effect-Site Target-Controlled Infusion in the Obese: Model Derivation and Performance Assessment.
Topics: Adult; Aged; Anesthetics, Intravenous; Body Mass Index; Body Weight; Consciousness; Consciousness Mo | 2018 |
Propofol Sedation for Intragastric Balloon Removal: Looking for the Optimal Body Weight Descriptor.
Topics: Adult; Body Mass Index; Body Weight; Conscious Sedation; Deep Sedation; Device Removal; Dose-Respons | 2019 |
Apheresis in three dogs weighing <14 kg.
Topics: Anesthetics; Animals; Blood Component Removal; Body Weight; Dexmedetomidine; Dogs; Hypnotics and Sed | 2013 |
An enriched simulation environment for evaluation of closed-loop anesthesia.
Topics: Algorithms; Anesthesia, Closed-Circuit; Atracurium; Body Weight; Computer Graphics; Computer Simulat | 2014 |
The effective effect-site propofol concentration for induction in morbidly obese patients using total body weight with a new pharmacokinetic model.
Topics: Body Weight; Humans; Intubation, Intratracheal; Male; Models, Chemical; Obesity, Morbid; Propofol | 2013 |
Propofol effect-site concentrations: hunt the k(e0).
Topics: Age Factors; Anesthetics, Intravenous; Blood-Brain Barrier; Body Height; Body Weight; Computer Simul | 2013 |
Propofol and fentanyl take longer for induction of anesthesia in aortic regurgitation: a case-controlled prospective study.
Topics: Adult; Aged; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Aortic Valve In | 2014 |
Performance of propofol target-controlled infusion models in the obese: pharmacokinetic and pharmacodynamic analysis.
Topics: Adult; Anesthetics, Intravenous; Bariatric Surgery; Body Mass Index; Body Weight; Consciousness; Con | 2014 |
Performance of propofol target-controlled infusion models in the obese: pharmacokinetic and pharmacodynamic analysis.
Topics: Adult; Anesthetics, Intravenous; Bariatric Surgery; Body Mass Index; Body Weight; Consciousness; Con | 2014 |
Performance of propofol target-controlled infusion models in the obese: pharmacokinetic and pharmacodynamic analysis.
Topics: Adult; Anesthetics, Intravenous; Bariatric Surgery; Body Mass Index; Body Weight; Consciousness; Con | 2014 |
Performance of propofol target-controlled infusion models in the obese: pharmacokinetic and pharmacodynamic analysis.
Topics: Adult; Anesthetics, Intravenous; Bariatric Surgery; Body Mass Index; Body Weight; Consciousness; Con | 2014 |
Perioperative respiratory complications following awake and deep extubation in children undergoing adenotonsillectomy.
Topics: Adenoidectomy; Airway Extubation; Anesthetics, Inhalation; Anesthetics, Intravenous; Body Weight; Ch | 2015 |
Multivariable analysis of anesthetic factors associated with time to extubation in dogs.
Topics: Acepromazine; Airway Extubation; Anesthesia; Anesthetics; Animals; Body Temperature; Body Weight; Do | 2014 |
[Neuromuscular effects of cisatracurium besylate in obese patients].
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Atracurium; Body Mass Inde | 2014 |
Effect of a neck collar on upper airway size in children sedated with propofol-midazolam combination during magnetic resonance imaging.
Topics: Airway Management; Airway Obstruction; Anatomy, Cross-Sectional; Body Weight; Child, Preschool; Cons | 2015 |
Refining Target-Controlled Infusion: An Assessment of Pharmacodynamic Target-Controlled Infusion of Propofol and Remifentanil Using a Response Surface Model of Their Combined Effects on Bispectral Index.
Topics: Adult; Age Factors; Aged; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Weight | 2016 |
Post-Exposure Exercise Fails to Ameliorate Memory Impairment Induced by Propofol and Ketamine in Developing Rats.
Topics: Anesthesia; Animals; Body Weight; Conditioning, Psychological; Female; Hippocampus; Immunohistochemi | 2016 |
Female Patients Require a Higher Propofol Infusion Rate for Sedation.
Topics: Age Factors; Aged; Anesthesia, Dental; Anesthetics, Intravenous; Blood Pressure; Body Weight; Consci | 2016 |
Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice.
Topics: Adult; Aged; Aged, 80 and over; Aging; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous | 2016 |
Etanercept, an inhibitor of TNF-a, prevents propofol-induced neurotoxicity in the developing brain.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroida | 2016 |
Urinary propofol metabolites in early life after single intravenous bolus.
Topics: Aging; Anesthetics, Intravenous; Body Weight; Humans; Hydroquinones; Infant; Infant, Newborn; Metabo | 2008 |
The direct effects of propofol on pial microvessels in rabbits.
Topics: Anesthetics, Intravenous; Animals; Arterioles; Blood Pressure; Body Temperature; Body Weight; Capill | 2009 |
Encouraging the move towards predictive population models for the obese using propofol as a motivating example.
Topics: Adolescent; Adult; Analysis of Variance; Anesthetics, Intravenous; Body Weight; Computer Simulation; | 2009 |
Total intravenous anaesthesia to obese patients: largely guesswork?
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Body Weight; Dose-Response Relationship, Drug; Hu | 2009 |
Pharmacokinetics and pharmacodynamics of a new reformulated microemulsion and the long-chain triglyceride emulsion of propofol in beagle dogs.
Topics: Anesthetics, Intravenous; Animals; Area Under Curve; Body Weight; Cross-Over Studies; Dogs; Dose-Res | 2009 |
Prediction of propofol clearance in children from an allometric model developed in rats, children and adults versus a 0.75 fixed-exponent allometric model.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Algorithms; Anesthetics, Intravenous; Anima | 2010 |
Which model for propofol TCI in children.
Topics: Age Factors; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Size; Body Weight; | 2010 |
Monitor-decoupled pharmacodymamics of propofol in children using State Entropy as the clinical end point.
Topics: Adolescent; Algorithms; Anesthetics, Intravenous; Body Weight; Child; Drug Monitoring; Electroenceph | 2010 |
Quantitative analysis of continuous intravenous infusions in pediatric anesthesia: safety implications of dead volume, flow rates, and fluid delivery.
Topics: Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Weight; Child; Child, Preschool; | 2011 |
[Population pharmacokinetic modeling and evaluation of propofol from multiple centers].
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthetics, Intravenous; Body Weight; Fema | 2010 |
Fasting times and gastric contents volume in children undergoing deep propofol sedation--an assessment using magnetic resonance imaging.
Topics: Adolescent; Anesthetics, Inhalation; Body Weight; Child; Child, Preschool; Data Interpretation, Stat | 2011 |
Effect of MRI strength and propofol sedation on pediatric core temperature change.
Topics: Adolescent; Age Factors; Anesthetics, Intravenous; Body Mass Index; Body Temperature; Body Weight; C | 2011 |
Anesthetizing the obese.
Topics: Anesthesia; Body Weight; Dose-Response Relationship, Drug; Humans; Metabolic Clearance Rate; Obesity | 2011 |
Risk factors for nausea and vomiting after day care general anesthesia in mentally challenged patients undergoing dental treatment.
Topics: Adolescent; Adult; Age Factors; Ambulatory Surgical Procedures; Anesthesia, Dental; Anesthesia, Gene | 2011 |
A bodyweight-dependent allometric exponent for scaling clearance across the human life-span.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anesthetics, Intravenous; Body Weigh | 2012 |
Allometric or lean body mass scaling of propofol pharmacokinetics: towards simplifying parameter sets for target-controlled infusions.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthetics, Intravenous; Body Size; Body W | 2012 |
The variability of response to propofol is reduced when a clinical observation is incorporated in the control: a simulation study.
Topics: Adult; Age Factors; Aged; Anesthetics, Intravenous; Body Weight; Computer Simulation; Consciousness; | 2012 |
The characteristics of the staircase phenomenon during the period of twitch stabilization in infants in TOF mode.
Topics: Analysis of Variance; Anesthesia; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intraveno | 2013 |
Evaluation of sigmoidal maturation and allometric models: prediction of propofol clearance in neonates and infants.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Body Weight; Child; Child, Preschool; Drug | 2013 |
Bispectral index dynamics during propofol hypnosis is similar in red-haired and dark-haired subjects.
Topics: Adult; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous; Bayes Theorem; Blood Pressure; | 2013 |
A manual slide rule for target-controlled infusion of propofol: development and evaluation.
Topics: Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Weight; Computers, Analog; Dose- | 2003 |
Population pharmacokinetics of propofol in Chinese patients.
Topics: Adult; Age Factors; Aged; Anesthetics, Intravenous; Asian People; Body Weight; China; Female; Humans | 2003 |
Propofol pharmacokinetics in a patient with bilateral leg amputation.
Topics: Aged; Aged, 80 and over; Amputees; Anesthetics, Intravenous; Body Constitution; Body Weight; Humans; | 2003 |
Propofol intravenous conscious sedation for anxious children in a specialist paediatric dentistry unit.
Topics: Adolescent; Anesthesia Recovery Period; Anesthesia, Dental; Anesthetics, Intravenous; Body Weight; C | 2004 |
Average recovery time from a standardized intravenous sedation protocol and standardized discharge criteria in the general dental practice setting.
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesia, Dental; Anesthesia, Intravenous; An | 2002 |
Behavioural phenotypes of hypomorphic KCC2-deficient mice.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Blotting, Wester | 2005 |
Allometric relationships between the pharmacokinetics of propofol in rats, children and adults.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Animals; Body Weight; Child, Preschool; Drug Evaluatio | 2005 |
A comparison of target-controlled infusion versus volatile inhalant anesthesia for heart rate, respiratory rate, and recovery time in a rat model.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Body Weight; F | 2005 |
Pharmacokinetics of a single bolus of propofol in chinese children of different ages.
Topics: Aging; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Weight; Child; Child, Pre | 2006 |
Influence of age and sex on pharmacodynamics of propofol in neurosurgical patients: model development.
Topics: Adolescent; Adult; Age Factors; Aged; Anesthetics, Intravenous; Body Weight; Female; Humans; Male; M | 2006 |
Predictive performance of 'Servin's formula' during BIS-guided propofol-remifentanil target-controlled infusion in morbidly obese patients.
Topics: Adult; Analgesics, Opioid; Anesthetics, Intravenous; Body Weight; Computer Simulation; Drug Delivery | 2007 |
Relationship between age and spontaneous ventilation during intravenous anesthesia in children.
Topics: Age Factors; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Height; Body Weight; Child; Chi | 2007 |
Maturational pharmacokinetics of single intravenous bolus of propofol.
Topics: Age Factors; Anesthetics, Intravenous; Body Weight; Humans; Infant, Newborn; Infusions, Intravenous; | 2007 |
Inter-individual variability in propofol pharmacokinetics in preterm and term neonates.
Topics: Aging; Anesthetics, Intravenous; Body Weight; Creatinine; Drug Administration Schedule; Female; Gest | 2007 |
Enhancement of antitumor immunity after propofol treatment in mice.
Topics: Adjuvants, Immunologic; Animals; Blood Proteins; Body Weight; Cell Count; Cell Line, Tumor; Fat Emul | 2007 |
Enhancement of antitumor immunity after propofol treatment in mice.
Topics: Adjuvants, Immunologic; Animals; Blood Proteins; Body Weight; Cell Count; Cell Line, Tumor; Fat Emul | 2007 |
Enhancement of antitumor immunity after propofol treatment in mice.
Topics: Adjuvants, Immunologic; Animals; Blood Proteins; Body Weight; Cell Count; Cell Line, Tumor; Fat Emul | 2007 |
Enhancement of antitumor immunity after propofol treatment in mice.
Topics: Adjuvants, Immunologic; Animals; Blood Proteins; Body Weight; Cell Count; Cell Line, Tumor; Fat Emul | 2007 |
Propofol pharmacokinetics in children with biliary atresia.
Topics: Biliary Atresia; Body Weight; Child, Preschool; Endoscopy; Humans; Infant; Liver; Metabolic Clearanc | 1995 |
Spontaneous movement after injection of propofol.
Topics: Adult; Anesthetics, Intravenous; Asian People; Body Weight; Dose-Response Relationship, Drug; Female | 1996 |
The influence of age and administration rate on the brain sensitivity to propofol in rats.
Topics: Aging; Anesthesia; Anesthetics, Intravenous; Animals; Body Weight; Brain; Dose-Response Relationship | 1998 |
Is total body weight an appropriate predictor for propofol maintenance dose?
Topics: Anesthetics, Dissociative; Anesthetics, Intravenous; Body Height; Body Mass Index; Body Weight; Chro | 1999 |
[The influence of age on hemodynamics and the dose requirements of propofol and buprenorphine in total intravenous anesthesia].
Topics: Adult; Aged; Aging; Anesthesia Recovery Period; Anesthesia, Intravenous; Body Weight; Buprenorphine; | 2001 |
The determinants of propofol induction of anesthesia dose.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anesthetics, Intravenous; Body Weight; Card | 2001 |
[Hemodynamic changes during slow induction of anesthesia using propofol and the effect of cardiac output on the propofol concentration].
Topics: Adult; Age Factors; Anesthesia, Intravenous; Body Weight; Cardiac Output; Female; Hemodynamics; Huma | 2001 |
[Anesthetic management of a morbidly obese patient undergoing laparoscopic gastric bypass surgery].
Topics: Adult; Anesthesia, Epidural; Anesthesia, Intravenous; Body Weight; Gastric Bypass; Humans; Laparosco | 2001 |
Gender differences in the pharmacokinetics of propofol in elderly patients during and after continuous infusion.
Topics: Aged; Aged, 80 and over; Aging; Anesthetics, Intravenous; Body Weight; Computer Simulation; Female; | 2001 |
[Comment on the use of targeted propofol infusion].
Topics: Age Factors; Algorithms; Anesthetics, Intravenous; Body Weight; Humans; Propofol; Tissue Distributio | 2001 |
Haemodynamic effects of propofol: induction with 2.5 mg kg-1.
Topics: Adult; Anesthesia, Dental; Anesthesia, Intravenous; Blood Pressure; Body Weight; Cardiac Output; Fem | 1991 |
Haemodynamic effects of propofol: induction with 2.5 mg kg-1.
Topics: Adult; Anesthesia, Dental; Anesthesia, Intravenous; Blood Pressure; Body Weight; Cardiac Output; Fem | 1991 |
Haemodynamic effects of propofol: induction with 2.5 mg kg-1.
Topics: Adult; Anesthesia, Dental; Anesthesia, Intravenous; Blood Pressure; Body Weight; Cardiac Output; Fem | 1991 |
Haemodynamic effects of propofol: induction with 2.5 mg kg-1.
Topics: Adult; Anesthesia, Dental; Anesthesia, Intravenous; Blood Pressure; Body Weight; Cardiac Output; Fem | 1991 |
Haemodynamic effects of propofol: induction with 2.5 mg kg-1.
Topics: Adult; Anesthesia, Dental; Anesthesia, Intravenous; Blood Pressure; Body Weight; Cardiac Output; Fem | 1991 |
Haemodynamic effects of propofol: induction with 2.5 mg kg-1.
Topics: Adult; Anesthesia, Dental; Anesthesia, Intravenous; Blood Pressure; Body Weight; Cardiac Output; Fem | 1991 |
Haemodynamic effects of propofol: induction with 2.5 mg kg-1.
Topics: Adult; Anesthesia, Dental; Anesthesia, Intravenous; Blood Pressure; Body Weight; Cardiac Output; Fem | 1991 |
Haemodynamic effects of propofol: induction with 2.5 mg kg-1.
Topics: Adult; Anesthesia, Dental; Anesthesia, Intravenous; Blood Pressure; Body Weight; Cardiac Output; Fem | 1991 |
Haemodynamic effects of propofol: induction with 2.5 mg kg-1.
Topics: Adult; Anesthesia, Dental; Anesthesia, Intravenous; Blood Pressure; Body Weight; Cardiac Output; Fem | 1991 |
Pharmacokinetics of atracurium during continuous infusion.
Topics: Anesthesia, Intravenous; Atracurium; Body Mass Index; Body Weight; Female; Humans; Infusions, Intrav | 1990 |
Intravenous anaesthesia with propofol and alfentanil. The influence of age and weight.
Topics: Adult; Age Factors; Aged; Alfentanil; Anesthesia, Intravenous; Anesthetics; Blood Pressure; Body Wei | 1986 |
Pharmacokinetics and protein binding of propofol in patients with cirrhosis.
Topics: Adult; Anesthetics; Blood Proteins; Body Weight; Female; Half-Life; Humans; Liver; Liver Cirrhosis; | 1988 |