propofol has been researched along with Asthma in 28 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propofol, an intravenous anesthetic agent widely used in clinical practice, is the preferred anesthetic for asthmatic patients." | 7.88 | Propofol Attenuates Airway Inflammation in a Mast Cell-Dependent Mouse Model of Allergic Asthma by Inhibiting the Toll-like Receptor 4/Reactive Oxygen Species/Nuclear Factor κB Signaling Pathway. ( Huang, YG; Li, HY; Liu, XW; Liu, Z; Meng, JX; Zhao, J, 2018) |
| " Although its mechanism of smooth muscle relaxation is unknown, propofol has been associated with less bronchoconstriction during anaesthetic induction." | 7.74 | Investigation of the relaxant effects of propofol on ovalbumin-induced asthma in guinea pigs. ( Bagcivan, I; Cevit, O; Gursoy, S; Kaya, T; Mimaroglu, C; Yildirim, MK; Yildirim, S, 2007) |
| " Anesthesia was induced with propofol and ketamine under the Sellick maneuver." | 7.70 | [Bronchospasm during crush induction with propofol under the Sellick maneuver in a patient for emergency laparotomy]. ( Doi, K; Saito, Y; Sato, K; Yamada, Y; Yamamori, Y, 1999) |
| "Halothane was administered subsequently at a concentration of 1 MAC." | 6.68 | Propofol or halothane anaesthesia for children with asthma: effects on respiratory mechanics. ( Habre, W; Matsumoto, I; Sly, PD, 1996) |
| "Both asthmatic and nonasthmatic patients who received a thiobarbiturate for induction had a greater incidence of wheezing than did patients receiving propofol." | 5.08 | Wheezing during induction of general anesthesia in patients with and without asthma. A randomized, blinded trial. ( Baker, S; Baranov, D; Brown, RH; Hennes, H; Hirshman, CA; Pizov, R; Weiss, YS, 1995) |
| "Propofol, a new intravenous sedative agent, was investigated in 41 asthmatic patients undergoing day-case (outpatient) fiberoptic bronchoscopy." | 5.07 | A comparative evaluation of propofol and midazolam as sedative agents in fiberoptic bronchoscopy. ( Burke, CM; Clarkson, K; O'Connell, F; Pathmakanthan, S; Power, CK, 1993) |
| "Propofol, an intravenous anesthetic agent widely used in clinical practice, is the preferred anesthetic for asthmatic patients." | 3.88 | Propofol Attenuates Airway Inflammation in a Mast Cell-Dependent Mouse Model of Allergic Asthma by Inhibiting the Toll-like Receptor 4/Reactive Oxygen Species/Nuclear Factor κB Signaling Pathway. ( Huang, YG; Li, HY; Liu, XW; Liu, Z; Meng, JX; Zhao, J, 2018) |
| "The aim of this study was to assess the feasibility, safety, and both patients' and bronchoscopists' satisfaction with propofol and remifentanil sedation administered by specialized sedation anesthesiology nurses during BT in severe asthma patients." | 3.85 | Propofol and Remifentanil Sedation for Bronchial Thermoplasty: A Prospective Cohort Trial. ( Annema, JT; Bonta, PI; d'Hooghe, JN; Eberl, S, 2017) |
| "Propofol has been shown to attenuate airway hyperresponsiveness in asthma patients." | 3.83 | Propofol inhibits T-helper cell type-2 differentiation by inducing apoptosis via activating gamma-aminobutyric acid receptor. ( Huang, B; Huang, Y; Li, H; Liu, Z; Meng, J; Xin, X; Zhao, J, 2016) |
| " Although its mechanism of smooth muscle relaxation is unknown, propofol has been associated with less bronchoconstriction during anaesthetic induction." | 3.74 | Investigation of the relaxant effects of propofol on ovalbumin-induced asthma in guinea pigs. ( Bagcivan, I; Cevit, O; Gursoy, S; Kaya, T; Mimaroglu, C; Yildirim, MK; Yildirim, S, 2007) |
| " Anesthesia was induced with propofol and ketamine under the Sellick maneuver." | 3.70 | [Bronchospasm during crush induction with propofol under the Sellick maneuver in a patient for emergency laparotomy]. ( Doi, K; Saito, Y; Sato, K; Yamada, Y; Yamamori, Y, 1999) |
| "Propofol is probably a safe agent in asthmatic patients." | 3.69 | [Diprivan and asthma]. ( Dureuil, B, 1994) |
| "Halothane was administered subsequently at a concentration of 1 MAC." | 2.68 | Propofol or halothane anaesthesia for children with asthma: effects on respiratory mechanics. ( Habre, W; Matsumoto, I; Sly, PD, 1996) |
| "Propofol is an oil at room temperature and insoluble in aqueous solution." | 2.42 | Propofol: therapeutic indications and side-effects. ( Marik, PE, 2004) |
| "Propofol is a common drug used for anesthetic induction of patients undergoing surgery." | 1.33 | Asthma, sedation, and the podiatric patient. ( Hilgerson, A; Mandi, D; Stefani, S; Toney, PA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 10 (35.71) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 7 (25.00) | 24.3611 |
| 2020's | 1 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Garner, O | 1 |
| Ramey, JS | 1 |
| Hanania, NA | 1 |
| Zhang, Q | 1 |
| Wang, L | 1 |
| Chen, B | 1 |
| Zhuo, Q | 1 |
| Bao, C | 1 |
| Lin, L | 1 |
| Li, HY | 1 |
| Meng, JX | 1 |
| Liu, Z | 2 |
| Liu, XW | 1 |
| Huang, YG | 1 |
| Zhao, J | 2 |
| Heard, C | 1 |
| Harutunians, M | 1 |
| Houck, J | 1 |
| Joshi, P | 1 |
| Johnson, K | 1 |
| Lerman, J | 1 |
| d'Hooghe, JN | 1 |
| Eberl, S | 1 |
| Annema, JT | 1 |
| Bonta, PI | 1 |
| Meng, J | 1 |
| Xin, X | 1 |
| Li, H | 1 |
| Huang, B | 1 |
| Huang, Y | 1 |
| Fontaine, M | 1 |
| Dubost, J | 1 |
| Bienvenu, F | 1 |
| Ferrenq Dubost, R | 1 |
| Proton, G | 1 |
| Piriou, V | 1 |
| Soto Mesa, D | 1 |
| Bermejo Alvarez, MA | 1 |
| Rubio Marauri, P | 1 |
| García Menéndez, MJ | 1 |
| Hidano, G | 1 |
| Nagata, O | 1 |
| Narushima, M | 1 |
| Ozaki, M | 1 |
| Culp, KE | 1 |
| Augoustides, JG | 1 |
| Ochroch, AE | 1 |
| Milas, BL | 1 |
| Marik, PE | 1 |
| Toney, PA | 1 |
| Hilgerson, A | 1 |
| Stefani, S | 1 |
| Mandi, D | 1 |
| Gómez Ayechu, M | 1 |
| Castañeda Pascual, M | 1 |
| Zaballos Barcala, N | 1 |
| Unzué Rico, P | 1 |
| Bagcivan, I | 1 |
| Cevit, O | 1 |
| Yildirim, MK | 1 |
| Gursoy, S | 1 |
| Yildirim, S | 1 |
| Kaya, T | 1 |
| Mimaroglu, C | 1 |
| Pizov, R | 1 |
| Brown, RH | 1 |
| Weiss, YS | 1 |
| Baranov, D | 1 |
| Hennes, H | 1 |
| Baker, S | 1 |
| Hirshman, CA | 1 |
| Dureuil, B | 1 |
| Clarkson, K | 1 |
| Power, CK | 1 |
| O'Connell, F | 1 |
| Pathmakanthan, S | 1 |
| Burke, CM | 1 |
| Marinella, MA | 1 |
| Habre, W | 1 |
| Matsumoto, I | 1 |
| Sly, PD | 1 |
| Kakinohana, M | 1 |
| Fujimine, T | 1 |
| Kakinohana, O | 1 |
| Yamada, Y | 1 |
| Doi, K | 1 |
| Sato, K | 1 |
| Yamamori, Y | 1 |
| Saito, Y | 1 |
| Ishihara, H | 1 |
| Sakai, T | 1 |
| Matsuki, A | 1 |
| White, PF | 1 |
| Giesecke, AH | 1 |
| Nishiyama, T | 1 |
| Hanaoka, K | 1 |
| Hepner, DL | 1 |
| Pedersen, CM | 1 |
| Bilbault, P | 2 |
| Boisson-Bertrand, D | 2 |
| Duvivier, C | 2 |
| Peslin, R | 2 |
| Laxenaire, MC | 2 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Large Antecubital Vein Versus Small Vein on Dorsum of Hand for the Prevention of Propofol Injection Pain[NCT04673500] | 160 participants (Actual) | Interventional | 2013-05-31 | Completed | |||
| A Multi-center, Double-blind, Randomized, Controlled Study to Determine the Efficacy and Safety of a New Formulation of Acetylcysteine Injection[NCT01118663] | Phase 3 | 17 participants (Actual) | Interventional | 2010-09-30 | Terminated | ||
| Comparison Between Ondansetron 8 mg and Lidocain 40 mg in Preventing Pain Due to Propofol Injection[NCT03134612] | Phase 2 | 104 participants (Actual) | Interventional | 2016-07-31 | Completed | ||
| [NCT00440960] | Phase 4 | 0 participants | Interventional | Completed | |||
| Evaluation of a Novel Closed-loop Propofol and Remifentanil System Guided by Bispectral Index Compared to a TCI Open-loop System: a Randomized Controlled Trial.[NCT02492282] | Phase 3 | 150 participants (Actual) | Interventional | 2015-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Data analysis was conducted on the subjects enrolled in the study prior to study termination. Because the study was terminated prematurely due to lack of enrollment, there was an insufficient sample size to conduct an efficacy analysis. (NCT01118663)
Timeframe: 1 hour
| Intervention | participants (Number) |
|---|---|
| Acetadote Without EDTA | 0 |
| Acetadote | 1 |
(NCT01118663)
Timeframe: 21-42 hours
| Intervention | Number of Events (Number) |
|---|---|
| Acetadote Without EDTA | 13 |
| Acetadote | 14 |
3 reviews available for propofol and Asthma
| Article | Year |
|---|---|
Management of Life-Threatening Asthma: Severe Asthma Series.
Topics: Adrenal Cortex Hormones; Asthma; Humans; Ketamine; Magnesium Sulfate; Muscarinic Antagonists; Propof | 2022 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
Propofol: therapeutic indications and side-effects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Asthma; Craniocerebral Trauma; Delirium; Huma | 2004 |
[Applicability of intravenous anesthesia--special reference to propofol and ketamine].
Topics: Anesthesia, Intravenous; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, Intravenou | 1999 |
4 trials available for propofol and Asthma
| Article | Year |
|---|---|
Propofol anesthesia for children undergoing magnetic resonance imaging: a comparison with isoflurane, nitrous oxide, and a laryngeal mask airway.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Asthma; Child; Child, Preschool; Cognition Disord | 2015 |
Wheezing during induction of general anesthesia in patients with and without asthma. A randomized, blinded trial.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Asthma; Barbiturates; Female; Humans; Incidence; Male; | 1995 |
A comparative evaluation of propofol and midazolam as sedative agents in fiberoptic bronchoscopy.
Topics: Ambulatory Care; Asthma; Bronchoscopy; Dose-Response Relationship, Drug; Fiber Optic Technology; Hum | 1993 |
Propofol or halothane anaesthesia for children with asthma: effects on respiratory mechanics.
Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Asthma; Child; Child, Presch | 1996 |
21 other studies available for propofol and Asthma
| Article | Year |
|---|---|
Propofol inhibits NF-κB activation to ameliorate airway inflammation in ovalbumin (OVA)-induced allergic asthma mice.
Topics: Allergens; Anesthetics; Animals; Anti-Allergic Agents; Asthma; Cell Line; Disease Models, Animal; Hu | 2017 |
Propofol Attenuates Airway Inflammation in a Mast Cell-Dependent Mouse Model of Allergic Asthma by Inhibiting the Toll-like Receptor 4/Reactive Oxygen Species/Nuclear Factor κB Signaling Pathway.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Inflammation; Mast Cells; Mice; NF-kappa B; Propofol; | 2018 |
Propofol and Remifentanil Sedation for Bronchial Thermoplasty: A Prospective Cohort Trial.
Topics: Adult; Anesthetics, Intravenous; Asthma; Bronchoscopy; Conscious Sedation; Female; Humans; Male; Mid | 2017 |
Propofol inhibits T-helper cell type-2 differentiation by inducing apoptosis via activating gamma-aminobutyric acid receptor.
Topics: Animals; Anti-Asthmatic Agents; Apoptosis; Asthma; Biomarkers; Cell Differentiation; Cell Proliferat | 2016 |
[Severe bronchospasm using Diprivan® in a patient allergic to peanut and birch].
Topics: Anesthesia, General; Asthma; Betula; Bronchial Spasm; Child; Drug Hypersensitivity; Humans; Hypnotic | 2011 |
[Anesthetic considerations in Charcot-Marie-Tooth disease].
Topics: Adult; Airway Management; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthesia, Obstetrical; | 2011 |
[Transient increase of bispectral index in a patient with bronchoconstriction after endotracheal intubation].
Topics: Anesthesia, General; Appendectomy; Asthma; Bronchial Diseases; Constriction, Pathologic; Female; Fen | 2004 |
Clinical management of cardiogenic shock associated with prolonged propofol infusion.
Topics: Adolescent; Anesthetics, Intravenous; Asthma; Electrocardiography; Extracorporeal Membrane Oxygenati | 2004 |
Asthma, sedation, and the podiatric patient.
Topics: Asthma; Female; Humans; Hypnotics and Sedatives; Middle Aged; Podiatry; Propofol; Surgical Procedure | 2006 |
[Anesthetic implications of Swyer-James syndrome].
Topics: Adolescent; Anesthesia, Intravenous; Asthma; Atracurium; Atropine; Bronchiectasis; Drainage; Fentany | 2006 |
Investigation of the relaxant effects of propofol on ovalbumin-induced asthma in guinea pigs.
Topics: Animals; Asthma; Calcium Channels; Disease Models, Animal; Guinea Pigs; Hypnotics and Sedatives; Iso | 2007 |
[Diprivan and asthma].
Topics: Airway Resistance; Asthma; Bronchial Spasm; Humans; Propofol; Surgical Procedures, Operative | 1994 |
Lactic acidosis associated with propofol.
Topics: Acidosis, Lactic; Adult; Anti-Asthmatic Agents; Asthma; Bicarbonates; Female; Humans; Hypnotics and | 1996 |
[Propofol anesthesia for an emergent caesarean section in a patient with asthma].
Topics: Adult; Anesthesia, General; Anesthesia, Obstetrical; Anesthetics, Intravenous; Asthma; Cesarean Sect | 1999 |
[Bronchospasm during crush induction with propofol under the Sellick maneuver in a patient for emergency laparotomy].
Topics: Anesthesia; Asthma; Bronchial Spasm; Emergencies; Humans; Intestinal Obstruction; Intubation, Intrat | 1999 |
Use of an EEG-bispectral closed-loop delivery system for administering propofol.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Intravenous; Anesthetics, Intravenous; Asthma; Electroence | 2000 |
Propofol-induced bronchoconstriction: two case reports.
Topics: Adult; Anesthesia; Anesthetics, Intravenous; Asthma; Breast Neoplasms; Bronchoconstriction; Female; | 2001 |
Propofol-induced bronchoconstriction: asthma or allergy?
Topics: Anaphylaxis; Anesthetics, Intravenous; Asthma; Bronchoconstriction; Diagnosis, Differential; Humans; | 2002 |
The effect of sedation with propofol on postoperative bronchoconstriction in patients with hyperreactive airway disease.
Topics: Aged; Aortic Valve Stenosis; Asthma; Bronchial Spasm; Humans; Lung Volume Measurements; Male; Postop | 1992 |
[Effect of the association propofol-alfentanil on bronchial resistances in asthmatic patients].
Topics: Adult; Airway Resistance; Alfentanil; Asthma; Bronchi; Clinical Protocols; Drug Combinations; Female | 1991 |
[Repercussions of propofol and combinations with alfentanyl on the bronchial reactivity in asthmatics].
Topics: Alfentanil; Anesthesia; Anesthetics; Asthma; Bronchi; Female; Humans; Male; Middle Aged; Propofol | 1989 |