propofol has been researched along with Apoplexy in 20 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It is uncertain if dexmedetomidine has more favorable pharmacokinetic profile than the traditional sedative drug propofol in patients who undergo endovascular therapy for acute stroke." | 9.30 | The safety and efficacy of dexmedetomidine versus propofol for patients undergoing endovascular therapy for acute stroke: A prospective randomized control trial. ( Cai, A; Hu, H; Liu, S; Ren, C; Wu, B, 2019) |
| "In stroke patients undergoing endovascular thrombectomy treated using general anesthesia, there may be a differential effect between intravenous propofol and volatile inhalational agents." | 8.02 | Intravenous Propofol Versus Volatile Anesthetics For Stroke Endovascular Thrombectomy. ( Barber, PA; Campbell, D; Chiou, D; Diprose, WK; Lai, J; McFetridge, A; Sutcliffe, JA; Wang, MTM, 2021) |
| "It has been shown in our previous study that propofol postconditioning enhanced the activity of phosphatidylinositol-3-kinase (PI3K) and prevented the internalization of GluR2 subunit of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thus provided neuroprotection in cerebral ischemia/reperfusion (I/R) injury." | 7.81 | The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats. ( Liu, S; Wang, G; Wang, H; Zhu, A, 2015) |
| "There is limited data on the safety, hemodynamic profile, and outcome of patients undergoing intra-arterial therapy (IAT) for acute ischemic stroke (AIS) under sedation with dexmedetomidine (DEX) versus propofol (PROP)." | 7.81 | Safety and Hemodynamic Profile of Propofol and Dexmedetomidine Anesthesia during Intra-arterial Acute Stroke Therapy. ( Dupler, S; Farag, E; Gomes, J; Hussain, MS; John, S; Somal, J; Thebo, U, 2015) |
| "Our results support the use of propofol sedation during the early postoperative period after craniotomy in hemorrhagic stroke patients, because it improved both neurologic and clinical outcomes." | 7.75 | Effects of propofol sedation during the early postoperative period in hemorrhagic stroke patients. ( Chen, HY; Chen, TY; Hung, YC; Ko, SW; Lee, EJ; Shyr, MH, 2009) |
| "To examine whether patients with previous stroke have impaired cerebrovascular carbon dioxide (CO2) reactivity when receiving propofol anesthesia." | 7.72 | Cerebrovascular carbon dioxide reactivity with propofol anesthesia in patients with previous stroke. ( Goto, F; Hinohara, H; Kadoi, Y; Saito, S; Takahashi, K, 2004) |
| "Propofol is an intravenous anesthetic that is commonly used during intravascular embolectomy following acute ischemic stroke." | 5.56 | Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke. ( Cui, V; Tian, D; Wang, H; Wang, Y; Wei, C; Wu, A; Yue, Y; Zhu, Y, 2020) |
| "Propofol treatment reduced infarct volume and improved the neurological functions." | 5.39 | Propofol protects against focal cerebral ischemia via inhibition of microglia-mediated proinflammatory cytokines in a rat model of experimental stroke. ( Liu, F; Tan, Y; Tang, X; Wu, X; Yang, Z; Zhou, R, 2013) |
| "KEep Evaluating Protocol Simplification In Managing Periinterventional Light Sedation for Endovascular Stroke Treatment (KEEP SIMPLEST) was a prospective, single-center observational study aimed to compare aspects of periinterventional management in AIS patients treated according to our new SOP using a combination of esketamine and propofol with patients having been randomized into conscious sedation (CS) in the Sedation versus Intubation for Endovascular Stroke TreAtment (SIESTA) trial." | 5.30 | The KEEP SIMPLEST Study: Improving In-House Delays and Periinterventional Management in Stroke Thrombectomy-A Matched Pair Analysis. ( Bendszus, M; Bösel, J; Heidenreich, P; Kieser, M; Möhlenbruch, MA; Pfaff, J; Ringleb, PA; Schieber, S; Schönenberger, S; Uhlmann, L; Ungerer, MN; Weber, D; Wick, W, 2019) |
| "It is uncertain if dexmedetomidine has more favorable pharmacokinetic profile than the traditional sedative drug propofol in patients who undergo endovascular therapy for acute stroke." | 5.30 | The safety and efficacy of dexmedetomidine versus propofol for patients undergoing endovascular therapy for acute stroke: A prospective randomized control trial. ( Cai, A; Hu, H; Liu, S; Ren, C; Wu, B, 2019) |
| "Comparison of the length of mechanical ventilation and postoperative complications after coronary surgery in elderly patients anaesthetised with propofol associated with either alfentanil or remifentanil." | 5.11 | [Continuous infusion of remifentanil and target-controlled infusion of propofol for coronary surgery in elderly patients: comparison with continuous infusion of remifentanil and propofol]. ( Blin, D; Chavanon, O; Durand, M; Gardellin, M; Girardet, P; Maitrasse, B; Robin, S, 2004) |
| "Ninety-three patients with anterior circulation stroke who received propofol or volatile GA during ET between February 2015 and February 2018 were included in this retrospective study." | 4.84 | The Effect of Anesthetic Agent and Mean Arterial Pressure on Functional Outcome After General Anesthesia for Endovascular Thrombectomy. ( Ayotte, S; Crimmins, D; Highton, D; Lwin, TN; Redmond, K; Ryan, E; Shah, D, 2024) |
| "In stroke patients undergoing endovascular thrombectomy treated using general anesthesia, there may be a differential effect between intravenous propofol and volatile inhalational agents." | 4.02 | Intravenous Propofol Versus Volatile Anesthetics For Stroke Endovascular Thrombectomy. ( Barber, PA; Campbell, D; Chiou, D; Diprose, WK; Lai, J; McFetridge, A; Sutcliffe, JA; Wang, MTM, 2021) |
| "It has been shown in our previous study that propofol postconditioning enhanced the activity of phosphatidylinositol-3-kinase (PI3K) and prevented the internalization of GluR2 subunit of α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thus provided neuroprotection in cerebral ischemia/reperfusion (I/R) injury." | 3.81 | The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats. ( Liu, S; Wang, G; Wang, H; Zhu, A, 2015) |
| "There is limited data on the safety, hemodynamic profile, and outcome of patients undergoing intra-arterial therapy (IAT) for acute ischemic stroke (AIS) under sedation with dexmedetomidine (DEX) versus propofol (PROP)." | 3.81 | Safety and Hemodynamic Profile of Propofol and Dexmedetomidine Anesthesia during Intra-arterial Acute Stroke Therapy. ( Dupler, S; Farag, E; Gomes, J; Hussain, MS; John, S; Somal, J; Thebo, U, 2015) |
| "Our results support the use of propofol sedation during the early postoperative period after craniotomy in hemorrhagic stroke patients, because it improved both neurologic and clinical outcomes." | 3.75 | Effects of propofol sedation during the early postoperative period in hemorrhagic stroke patients. ( Chen, HY; Chen, TY; Hung, YC; Ko, SW; Lee, EJ; Shyr, MH, 2009) |
| "To examine whether patients with previous stroke have impaired cerebrovascular carbon dioxide (CO2) reactivity when receiving propofol anesthesia." | 3.72 | Cerebrovascular carbon dioxide reactivity with propofol anesthesia in patients with previous stroke. ( Goto, F; Hinohara, H; Kadoi, Y; Saito, S; Takahashi, K, 2004) |
| "Propofol is an intravenous anesthetic that is commonly used during intravascular embolectomy following acute ischemic stroke." | 1.56 | Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke. ( Cui, V; Tian, D; Wang, H; Wang, Y; Wei, C; Wu, A; Yue, Y; Zhu, Y, 2020) |
| "Stroke is one of the leading causes of mortality and disability worldwide with limited clinical therapies available." | 1.56 | Propofol protects against oxygen/glucose deprivation‑induced cell injury via gap junction inhibition in astrocytes. ( Fan, Y; Wang, J; Wang, X; Zhao, Y; Zhu, S, 2020) |
| "Propofol treatment reduced infarct volume and improved the neurological functions." | 1.39 | Propofol protects against focal cerebral ischemia via inhibition of microglia-mediated proinflammatory cytokines in a rat model of experimental stroke. ( Liu, F; Tan, Y; Tang, X; Wu, X; Yang, Z; Zhou, R, 2013) |
| "Propofol has not been studied directly in animals subject to cerebral ischemia in the conscious state." | 1.31 | Propofol anesthesia compared to awake reduces infarct size in rats. ( Bayona, NA; Cechetto, DF; Gelb, AW; Wilson, JX, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 7 (35.00) | 24.3611 |
| 2020's | 7 (35.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crimmins, D | 2 |
| Ryan, E | 2 |
| Shah, D | 2 |
| Lwin, TN | 2 |
| Ayotte, S | 2 |
| Redmond, K | 2 |
| Highton, D | 2 |
| Diprose, WK | 1 |
| Wang, MTM | 1 |
| Campbell, D | 1 |
| Sutcliffe, JA | 1 |
| McFetridge, A | 1 |
| Chiou, D | 1 |
| Lai, J | 1 |
| Barber, PA | 1 |
| Wang, Y | 2 |
| Tian, D | 2 |
| Wei, C | 2 |
| Cui, V | 1 |
| Wang, H | 3 |
| Zhu, Y | 2 |
| Wu, A | 2 |
| Yue, Y | 1 |
| Klein, SP | 1 |
| Fieuws, S | 1 |
| Meyfroidt, G | 1 |
| Depreitere, B | 1 |
| Simonato, D | 1 |
| Ganau, M | 1 |
| Feltracco, P | 1 |
| Causin, F | 1 |
| Munari, M | 1 |
| Bortolato, A | 1 |
| Fan, Y | 1 |
| Zhu, S | 1 |
| Wang, J | 1 |
| Zhao, Y | 2 |
| Wang, X | 1 |
| Qu, M | 1 |
| Pan, Y | 1 |
| Rasmussen, M | 1 |
| Simonsen, CZ | 1 |
| Sørensen, LH | 1 |
| Dyrskog, S | 1 |
| Rusy, DA | 1 |
| Sharma, D | 1 |
| Juul, N | 1 |
| Schönenberger, S | 1 |
| Weber, D | 1 |
| Ungerer, MN | 1 |
| Pfaff, J | 1 |
| Schieber, S | 1 |
| Uhlmann, L | 1 |
| Heidenreich, P | 1 |
| Bendszus, M | 1 |
| Kieser, M | 1 |
| Wick, W | 1 |
| Möhlenbruch, MA | 1 |
| Ringleb, PA | 1 |
| Bösel, J | 1 |
| Wu, B | 1 |
| Hu, H | 1 |
| Cai, A | 1 |
| Ren, C | 1 |
| Liu, S | 2 |
| Mtaweh, H | 1 |
| Bayır, H | 1 |
| Kochanek, PM | 1 |
| Bell, MJ | 1 |
| Zhou, R | 1 |
| Yang, Z | 1 |
| Tang, X | 1 |
| Tan, Y | 1 |
| Wu, X | 1 |
| Liu, F | 1 |
| Wang, G | 1 |
| Zhu, A | 1 |
| John, S | 1 |
| Somal, J | 1 |
| Thebo, U | 1 |
| Hussain, MS | 1 |
| Farag, E | 1 |
| Dupler, S | 1 |
| Gomes, J | 1 |
| Hung, YC | 1 |
| Lee, EJ | 1 |
| Chen, HY | 1 |
| Ko, SW | 1 |
| Shyr, MH | 1 |
| Chen, TY | 1 |
| Gardellin, M | 1 |
| Durand, M | 1 |
| Maitrasse, B | 1 |
| Chavanon, O | 1 |
| Robin, S | 1 |
| Blin, D | 1 |
| Girardet, P | 1 |
| Hinohara, H | 1 |
| Kadoi, Y | 2 |
| Takahashi, K | 1 |
| Saito, S | 2 |
| Goto, F | 2 |
| Kawahara, F | 1 |
| Owada, R | 1 |
| Fujita, N | 1 |
| Bhardwaj, A | 1 |
| Castro III, AF | 1 |
| Alkayed, NJ | 1 |
| Hurn, PD | 1 |
| Kirsch, JR | 1 |
| Gelb, AW | 1 |
| Bayona, NA | 1 |
| Wilson, JX | 1 |
| Cechetto, DF | 1 |
3 trials available for propofol and Apoplexy
| Article | Year |
|---|---|
The KEEP SIMPLEST Study: Improving In-House Delays and Periinterventional Management in Stroke Thrombectomy-A Matched Pair Analysis.
Topics: Aged; Aged, 80 and over; Clinical Protocols; Conscious Sedation; Endovascular Procedures; Female; Hu | 2019 |
The safety and efficacy of dexmedetomidine versus propofol for patients undergoing endovascular therapy for acute stroke: A prospective randomized control trial.
Topics: Aged; Anesthesia Recovery Period; Dexmedetomidine; Endovascular Procedures; Female; Fibrinolytic Age | 2019 |
[Continuous infusion of remifentanil and target-controlled infusion of propofol for coronary surgery in elderly patients: comparison with continuous infusion of remifentanil and propofol].
Topics: Aged; Anesthetics, Intravenous; Coronary Disease; Humans; Infusions, Intravenous; Orthopedic Procedu | 2004 |
17 other studies available for propofol and Apoplexy
| Article | Year |
|---|---|
The Effect of Anesthetic Agent and Mean Arterial Pressure on Functional Outcome After General Anesthesia for Endovascular Thrombectomy.
Topics: Anesthesia, General; Anesthetics; Arterial Pressure; Brain Ischemia; Endovascular Procedures; Humans | 2024 |
The Effect of Anesthetic Agent and Mean Arterial Pressure on Functional Outcome After General Anesthesia for Endovascular Thrombectomy.
Topics: Anesthesia, General; Anesthetics; Arterial Pressure; Brain Ischemia; Endovascular Procedures; Humans | 2024 |
The Effect of Anesthetic Agent and Mean Arterial Pressure on Functional Outcome After General Anesthesia for Endovascular Thrombectomy.
Topics: Anesthesia, General; Anesthetics; Arterial Pressure; Brain Ischemia; Endovascular Procedures; Humans | 2024 |
The Effect of Anesthetic Agent and Mean Arterial Pressure on Functional Outcome After General Anesthesia for Endovascular Thrombectomy.
Topics: Anesthesia, General; Anesthetics; Arterial Pressure; Brain Ischemia; Endovascular Procedures; Humans | 2024 |
Intravenous Propofol Versus Volatile Anesthetics For Stroke Endovascular Thrombectomy.
Topics: Administration, Intravenous; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Endovascular P | 2021 |
Propofol Attenuates α-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke.
Topics: alpha-Synuclein; Animals; Behavior, Animal; Brain Infarction; Brain Ischemia; Disease Models, Animal | 2020 |
Effects of Norepinephrine, Propofol, and Hemoglobin Concentration on Dynamic Measurements of Cerebrovascular Reactivity in Acute Brain Injury.
Topics: Adult; Aged; Brain Injuries; Cerebrovascular Circulation; Female; Glycated Hemoglobin; Homeostasis; | 2021 |
Mechanical thrombectomy in a pediatric patient with sedation aided by contralateral intra-arterial propofol injection: feasibility in an extreme condition.
Topics: Adolescent; Brain Ischemia; Child; Feasibility Studies; Humans; Injections, Intra-Arterial; Male; Pr | 2021 |
Propofol protects against oxygen/glucose deprivation‑induced cell injury via gap junction inhibition in astrocytes.
Topics: Animals; Animals, Newborn; Apoptosis; Astrocytes; Cell Hypoxia; Cells, Cultured; Connexin 43; Down-R | 2020 |
Propofol Protects Regulatory T Cells, Suppresses Neurotoxic Astrogliosis, and Potentiates Neurological Recovery After Ischemic Stroke.
Topics: Brain Ischemia; Gliosis; Humans; Ischemic Stroke; Propofol; Recovery of Function; Stroke; T-Lymphocy | 2021 |
Anaesthesia practices for endovascular therapy of acute ischaemic stroke: a Nordic survey.
Topics: Anesthesia; Anesthetics; Anesthetics, Intravenous; Blood Pressure; Brain Ischemia; Conscious Sedatio | 2017 |
Effect of a single dose of propofol and lack of dextrose administration in a child with mitochondrial disease: a case report.
Topics: Acidosis, Lactic; Adolescent; Blood Pressure; Electroencephalography; Epilepsy; Female; Glucose; Hum | 2014 |
Propofol protects against focal cerebral ischemia via inhibition of microglia-mediated proinflammatory cytokines in a rat model of experimental stroke.
Topics: Animals; Biomarkers; Brain Ischemia; Cytokines; Disease Models, Animal; Gene Expression; Infarction, | 2013 |
The effect of propofol postconditioning on the expression of K(+)-Cl(-)-co-transporter 2 in GABAergic inhibitory interneurons of acute ischemia/reperfusion injury rats.
Topics: Acute Disease; Animals; Brain Ischemia; CA1 Region, Hippocampal; Carboxylic Acids; Cell Survival; Di | 2015 |
Safety and Hemodynamic Profile of Propofol and Dexmedetomidine Anesthesia during Intra-arterial Acute Stroke Therapy.
Topics: Aged; Aged, 80 and over; Blood Pressure; Brain Ischemia; Dexmedetomidine; Diffusion Magnetic Resonan | 2015 |
Effects of propofol sedation during the early postoperative period in hemorrhagic stroke patients.
Topics: Adult; Aged; Blood Platelets; Cerebral Hemorrhage; Cohort Studies; Craniotomy; Female; Hemodynamics; | 2009 |
Cerebrovascular carbon dioxide reactivity with propofol anesthesia in patients with previous stroke.
Topics: Anesthetics, Intravenous; Blood Gas Analysis; Carbon Dioxide; Cerebrovascular Circulation; Elective | 2004 |
Jugular venous bulb oxygen saturation in patients with preexisting diabetes mellitus or stroke during normothermic cardiopulmonary bypass.
Topics: Anesthetics, Intravenous; Blood Gas Analysis; Blood Glucose; Cardiopulmonary Bypass; Case-Control St | 2000 |
Anesthetic choice of halothane versus propofol: impact on experimental perioperative stroke.
Topics: Administration, Inhalation; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intrav | 2001 |
Propofol anesthesia compared to awake reduces infarct size in rats.
Topics: Anesthetics, Intravenous; Animals; Body Temperature; Brain; Cerebral Infarction; Cerebrovascular Cir | 2002 |