propofol and Apnea, Sleep studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Research Excerpts

Excerpt	Relevance	Reference
"Assessment of production of snoring or obstruction in patients with no documented history of snoring when sedation was administered as part of general anesthesia using target controlled infusion with propofol."	3.73	Validity of sleep nasendoscopy in the investigation of sleep related breathing disorders. ( Berry, S; Roblin, G; Watkins, A; Whittet, HB; Williams, A, 2005)
"We present the case of a nine-year-old boy afflicted with Ondine's curse, who developed complete atrioventricular heart block after a single bolus of propofol for induction of anaesthesia for strabismus surgery."	3.70	Heart block following propofol in a child. ( Deenen, D; Govaerts, MJ; Sochala, C; Ville, A, 1999)
"A vasectomy patient with sleep apnea syndrome, who requested general anesthesia and day surgery, was given sole propofol infusion with airway maintenance by noninvasive positive-pressure ventilation."	2.71	Combined local-propofol anesthesia with noninvasive positive pressure ventilation in a vasectomy patient with sleep apnea syndrome. ( Iwama, H; Suzuki, M, 2003)
"The treatment for obstructive sleep apnea syndrome (OSAS) depends on correct localization of upper airway obstruction, exception made for continuous positive airway pressure (CPAP)."	1.39	Polysomnographic evaluation of propofol-induced sleep in patients with respiratory sleep disorders and controls. ( Fernandes, RM; Küpper, DS; Rabelo, FA; Sander, HH; Valera, FC, 2013)
"Severe airway obstruction was defined as >75% collapse on endoscopy."	1.39	Drug-induced sleep endoscopy vs awake Müller's maneuver in the diagnosis of severe upper airway obstruction. ( Badr, MS; Folbe, AJ; Lin, HS; Rowley, JA; Soares, D; Yoo, G, 2013)

Research

Studies (18)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Number of Participants Who Experience Airway Maneuvers

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (11.11)	18.2507
2000's	3 (16.67)	29.6817
2010's	11 (61.11)	24.3611
2020's	2 (11.11)	2.80

Authors	Studies
Homberg, MC	1
Bouman, EAC	1
Joosten, BAJ	1
Urahama, R	1
Uesato, M	1
Aikawa, M	1
Kunii, R	1
Isono, S	1
Matsubara, H	1
Van de Perck, E	1
Vroegop, AV	2
Op de Beeck, S	1
Dieltjens, M	1
Verbruggen, AE	1
Van de Heyning, PH	2
Braem, MJ	2
Vanderveken, OM	2
Hayakawa, E	1
Barger, J	1
Main, W	1
Masters, E	1
Pershing, M	1
Patil, N	1
Kerner, B	1
Rabelo, FA	1
Küpper, DS	1
Sander, HH	1
Fernandes, RM	1
Valera, FC	1
Boudewyns, AN	1
Scholman, J	1
Saldien, V	1
Wouters, K	1
Hamans, E	1
Cavaliere, M	1
Russo, F	1
Iemma, M	1
Herzog, M	1
Kellner, P	1
Plößl, S	1
Glien, A	1
Rohrmeier, C	1
Kühnel, T	1
Plontke, S	1
Herzog, B	1
Coté, GA	1
Hovis, CE	1
Hovis, RM	1
Waldbaum, L	1
Early, DS	1
Edmundowicz, SA	1
Azar, RR	1
Mullady, DK	1
Jonnalagadda, SS	1
Ott, SR	1
Hamacher, J	1
Seifert, E	1
Borek, RC	1
Thaler, ER	1
Kim, C	1
Jackson, N	1
Mandel, JE	1
Schwab, RJ	1
Soares, D	1
Folbe, AJ	1
Yoo, G	1
Badr, MS	1
Rowley, JA	1
Lin, HS	1
Iwama, H	1
Suzuki, M	1
Berry, S	1
Roblin, G	2
Williams, A	1
Watkins, A	1
Whittet, HB	1
Lee, SM	1
Kim, GH	1
Lee, JJ	1
Kim, JA	1
Choi, SJ	1
Kim, GS	1
Jung, HH	1
Hendolin, H	1
Kansanen, M	1
Koski, E	1
Nuutinen, J	1
Sochala, C	1
Deenen, D	1
Ville, A	1
Govaerts, MJ	1
Williams, AR	1
Whittet, H	1

Trial	Enrollment	Study Type	Start Date	Status
The Role of Drug-Induced Sleep Endoscopy for the Optimisation of Treatment of Patients With Obstruction Sleep Apnoea[NCT02855515]	120 participants (Actual)	Interventional	2016-05-31	Completed
Incidence of Sedation Related Complications With Propofol Alone Versus Propofol With Benzodiazepines and Opiates in a High Risk Group Undergoing Advanced Endoscopic Procedures: A Randomized Controlled Trial[NCT01315158]	36 participants (Actual)	Interventional	2011-01-31	Terminated (stopped due to - The research team is not able to obtain the necessary support to continue the study.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

In high risk patients (meeting at least of 1 of 3 criteria: ASA ≥ 3, BMI ≥ 30, those at risk for OSA) undergoing advanced endoscopy procedures, compare the number of participants who experience airway maneuvers (AMs) when sedated with propofol alone versus propofol in combination with benzodiazepines and opioids. (NCT01315158)
Timeframe: One day (during procedure)

Number of Participants Who Experience Other Sedation Related Complications

Intervention	participants (Number)
Propofol+Benzo/Opioids	4
Propofol Alone	4

Compare the number of participants who experience other sedation related complications such as hypotension, hypoxemia and need for termination of the procedure between the two groups (NCT01315158)
Timeframe: One day (during procedure)

Number of Participants Who Experience Symptoms of Nausea and Vomiting Will be Compared Between the Two Groups

Intervention	participants (Number)
Propofol+Benzo/Opioids	0
Propofol Alone	0

The number of participants who experience symptoms of nausea and vomiting in the two groups of patients will be recorded. This will be recorded during the follow-up phone call made 24-48 hours after the procedure. (NCT01315158)
Timeframe: 24-48 hours

Article	Year
Combined local-propofol anesthesia with noninvasive positive pressure ventilation in a vasectomy patient with sleep apnea syndrome. Journal of clinical anesthesia, 2003, Volume: 15, Issue:5 Topics: Adult; Ambulatory Surgical Procedures; Anesthesia, Intravenous; Anesthesia, Local; Anesthetics, Intr	2003
Propofol-nitrous oxide versus thiopentone-isoflurane-nitrous oxide anaesthesia for uvulopalatopharyngoplasty in patients with sleep apnea. Acta anaesthesiologica Scandinavica, 1994, Volume: 38, Issue:7 Topics: Adult; Anesthesia, General; Anesthetics; Female; Humans; Isoflurane; Male; Middle Aged; Nitrous Oxid	1994

Article	Year
Occurrence of Cortical Arousal at Recovery from Respiratory Disturbances during Deep Propofol Sedation. International journal of environmental research and public health, 2019, 09-18, Volume: 16, Issue:18 Topics: Aged; Aged, 80 and over; Arousal; Dose-Response Relationship, Drug; Female; Humans; Hydrocortisone;	2019
Awake endoscopic assessment of the upper airway during tidal breathing: Definition of anatomical features and comparison with drug-induced sleep endoscopy. Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2021, Volume: 46, Issue:1 Topics: Adult; Endoscopy; Female; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Propofol; R	2021
Return to Normal Activity after Colonoscopy Using Propofol Sedation. The American surgeon, 2019, Apr-01, Volume: 85, Issue:4 Topics: Aged; Anesthesia; Body Mass Index; Colonoscopy; Conscious Sedation; Employment; Female; Humans; Hypn	2019
Polysomnographic evaluation of propofol-induced sleep in patients with respiratory sleep disorders and controls. The Laryngoscope, 2013, Volume: 123, Issue:9 Topics: Adult; Continuous Positive Airway Pressure; Cross-Sectional Studies; Female; Humans; Infusions, Intr	2013
Drug-induced sleep endoscopy in sleep-disordered breathing: report on 1,249 cases. The Laryngoscope, 2014, Volume: 124, Issue:3 Topics: Adult; Age Factors; Airway Obstruction; Anthropometry; Body Mass Index; Clinical Competence; Cohort	2014
Awake versus drug-induced sleep endoscopy: evaluation of airway obstruction in obstructive sleep apnea/hypopnoea syndrome. The Laryngoscope, 2013, Volume: 123, Issue:9 Topics: Adult; Airway Obstruction; Anesthetics, Intravenous; Cohort Studies; Endoscopy; Female; Humans; Lary	2013
Drug-induced sleep endoscopy and simulated snoring in patients with sleep-disordered breathing: agreement of anatomic changes in the upper airway. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2015, Volume: 272, Issue:9 Topics: Adult; Endoscopy; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Oropharynx; Palate, So	2015
A screening instrument for sleep apnea predicts airway maneuvers in patients undergoing advanced endoscopic procedures. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2010, Volume: 8, Issue:8 Topics: Aged; Deep Sedation; Endoscopy; Female; Humans; Male; Mass Screening; Middle Aged; Propofol; Respira	2010
Bringing light to the sirens of night: laryngoscopy in catathrenia during sleep. The European respiratory journal, 2011, Volume: 37, Issue:5 Topics: Adult; Continuous Positive Airway Pressure; Dyspnea; Female; Glottis; Humans; Hypnotics and Sedative	2011
Quantitative airway analysis during drug-induced sleep endoscopy for evaluation of sleep apnea. The Laryngoscope, 2012, Volume: 122, Issue:11 Topics: Anesthetics, Intravenous; Endoscopy; Female; Humans; Image Interpretation, Computer-Assisted; Male;	2012
Drug-induced sleep endoscopy vs awake Müller's maneuver in the diagnosis of severe upper airway obstruction. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2013, Volume: 148, Issue:1 Topics: Adult; Aged; Airway Obstruction; Anesthetics, Intravenous; Cohort Studies; Endoscopy; Female; Humans	2013
Validity of sleep nasendoscopy in the investigation of sleep related breathing disorders. The Laryngoscope, 2005, Volume: 115, Issue:3 Topics: Body Mass Index; Case-Control Studies; Endoscopy; Female; Humans; Hypnotics and Sedatives; Male; Mid	2005
Does propofol and alfentanil-induced sedation cause periodic apnoea in chronic renal failure patients? International journal of clinical practice, 2010, Volume: 64, Issue:1 Topics: Alfentanil; Anesthetics, Combined; Anesthetics, Intravenous; Apnea; Case-Control Studies; Female; Hu	2010
Heart block following propofol in a child. Paediatric anaesthesia, 1999, Volume: 9, Issue:4 Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Atrioventricular Node; Blood Pressure; Child; Ele	1999
Target-controlled infusion in sleep endoscopy. The Laryngoscope, 2001, Volume: 111, Issue:1 Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Endoscopy; Equipment Design; Humans; Infusion Pum	2001

propofol and Apnea, Sleep

Research Excerpts

Research

Studies (18)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Number of Participants Who Experience Airway Maneuvers

Number of Participants Who Experience Other Sedation Related Complications

Number of Participants Who Experience Symptoms of Nausea and Vomiting Will be Compared Between the Two Groups

Predictors of Sedation Related Complications as Measured by Early Procedure Termination for an Alternative Sedation Related Complication

Predictors of Sedation Related Complications as Measured by Hypopnea/Apnea (Defined as Fewer Than 6 Breaths/Minute Based on Capnography)

Predictors of Sedation Related Complications as Measured by the Incidences of Hypotension (Defined as Systolic Blood Pressure of Less Than 90mmHg or a Decrease of More Than 25% From Baseline)

Predictors of Sedation Related Complications as Measured by the Number of Participants Who Experience Hypoxemia (Defined as a Pulse Oximetry <90% for Any Duration)

Reviews

Trials

Other Studies