propofol has been researched along with Anoxia-Ischemia, Brain in 7 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rats underwent 2 h of middle cerebral artery occlusion (MCAO) followed by 22 h of reperfusion were randomly divided into nine groups (n=15 each): sham-operated group, MCAO group, propofol 10, 20 and 35 mg x kg(-1) x h(-1) group (propofol 10, 20, 35 mg x kg(-1) x h(-1) infused at the onset of reperfusion for 30 min), wortmannin group (wortmannin 0." | 5.35 | The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats. ( Wang, GL; Wang, HY; Wang, Y; Yu, YH, 2009) |
| " Research has shown that propofol, which is an intravenous anesthetic agent, exhibits neuroprotective effects against cerebral ischemia-reperfusion injury, although the neuroprotective mechanism is still unclear." | 3.76 | The effects of propofol on hippocampal caspase-3 and Bcl-2 expression following forebrain ischemia-reperfusion in rats. ( Han, B; Li, J; Ma, X; Qi, S, 2010) |
| "Traumatic brain injuries remain an area of great challenge to both neurosurgeons and neuroanaesthesiologists." | 2.45 | Traumatic brain injury: neuroprotective anaesthetic techniques, an update. ( Aal-Shaya, WA; Al-Faridi, K; Halawani, MM; Taha, WS; Tawfeeq, NA, 2009) |
| "Rats underwent 2 h of middle cerebral artery occlusion (MCAO) followed by 22 h of reperfusion were randomly divided into nine groups (n=15 each): sham-operated group, MCAO group, propofol 10, 20 and 35 mg x kg(-1) x h(-1) group (propofol 10, 20, 35 mg x kg(-1) x h(-1) infused at the onset of reperfusion for 30 min), wortmannin group (wortmannin 0." | 1.35 | The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats. ( Wang, GL; Wang, HY; Wang, Y; Yu, YH, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Barkhuizen, M | 1 |
| van Dijck, FJP | 1 |
| Jellema, RK | 1 |
| Gussenhoven, R | 1 |
| Engelbertink, I | 1 |
| van Mechelen, R | 1 |
| Cleutjens, JPM | 1 |
| Seehase, M | 1 |
| Steinbusch, HWM | 1 |
| Zimmermann, LJ | 1 |
| Gavilanes, AWD | 1 |
| Kramer, BW | 1 |
| Kortelainen, J | 1 |
| Väyrynen, E | 1 |
| Juuso, I | 1 |
| Laurila, J | 1 |
| Koskenkari, J | 1 |
| Ala-Kokko, T | 1 |
| Koutroumanidis, M | 1 |
| Sakellariou, D | 1 |
| Tsirka, V | 1 |
| Gong, HY | 1 |
| Zheng, F | 1 |
| Zhang, C | 1 |
| Chen, XY | 1 |
| Liu, JJ | 1 |
| Yue, XQ | 1 |
| Wang, HY | 1 |
| Wang, GL | 1 |
| Yu, YH | 1 |
| Wang, Y | 1 |
| Tawfeeq, NA | 1 |
| Halawani, MM | 1 |
| Al-Faridi, K | 1 |
| Aal-Shaya, WA | 1 |
| Taha, WS | 1 |
| Li, J | 1 |
| Han, B | 1 |
| Ma, X | 1 |
| Qi, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of EEG Slow Wave Activity in Comatose Cardiac Arrest Survivors Under Propofol Anesthesia[NCT04506788] | 25 participants (Actual) | Observational | 2015-06-15 | Completed | |||
| Assessment of EEG Changes During Induction of Propofol Anesthesia Using Wireless Measurement Devices[NCT03943745] | 50 participants (Anticipated) | Observational | 2018-10-25 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for propofol and Anoxia-Ischemia, Brain
| Article | Year |
|---|---|
Traumatic brain injury: neuroprotective anaesthetic techniques, an update.
Topics: Adolescent; Adult; Brain Injuries; Cell Death; Central Nervous System Depressants; Craniocerebral Tr | 2009 |
6 other studies available for propofol and Anoxia-Ischemia, Brain
| Article | Year |
|---|---|
The influence of anesthetics on substantia nigra tyrosine hydroxylase expression and tau phosphorylation in the hypoxic-ischemic near-term lamb.
Topics: Anesthetics; Animals; Animals, Newborn; Brain Mapping; Dopamine; Dopaminergic Neurons; Female; Gluta | 2018 |
Forehead electrodes sufficiently detect propofol-induced slow waves for the assessment of brain function after cardiac arrest.
Topics: Algorithms; Brain; Electrodes; Electroencephalography; Equipment Design; Forehead; Heart Arrest; Hum | 2020 |
Forehead electrodes sufficiently detect propofol-induced slow waves for the assessment of brain function after cardiac arrest.
Topics: Algorithms; Brain; Electrodes; Electroencephalography; Equipment Design; Forehead; Heart Arrest; Hum | 2020 |
Forehead electrodes sufficiently detect propofol-induced slow waves for the assessment of brain function after cardiac arrest.
Topics: Algorithms; Brain; Electrodes; Electroencephalography; Equipment Design; Forehead; Heart Arrest; Hum | 2020 |
Forehead electrodes sufficiently detect propofol-induced slow waves for the assessment of brain function after cardiac arrest.
Topics: Algorithms; Brain; Electrodes; Electroencephalography; Equipment Design; Forehead; Heart Arrest; Hum | 2020 |
"Paradoxical" EEG response to propofol may differentiate post-cardiac arrest non-convulsive status epilepticus from diffuse irreversible cerebral anoxia.
Topics: Diagnosis, Differential; Electroencephalography; Heart Arrest; Humans; Hypnotics and Sedatives; Hypo | 2014 |
Propofol protects hippocampal neurons from apoptosis in ischemic brain injury by increasing GLT-1 expression and inhibiting the activation of NMDAR via the JNK/Akt signaling pathway.
Topics: Anesthetics, Intravenous; Animals; Apoptosis; Blotting, Western; Cell Hypoxia; Cell Survival; Cells, | 2016 |
The role of phosphoinositide-3-kinase/Akt pathway in propofol-induced postconditioning against focal cerebral ischemia-reperfusion injury in rats.
Topics: Androstadienes; Animals; Brain; Brain Infarction; Disease Models, Animal; Dose-Response Relationship | 2009 |
The effects of propofol on hippocampal caspase-3 and Bcl-2 expression following forebrain ischemia-reperfusion in rats.
Topics: Anesthetics, Intravenous; Animals; Caspase 3; Disease Models, Animal; Hippocampus; Hypoxia-Ischemia, | 2010 |