propofol has been researched along with Anoxia, Brain in 17 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of propofol on the three kinds of brain injuries induced by metabolic disorder, neurotoxicity of excitatory amino acid, and oxygen-derived free radicals in rat cerebral cortical and hippocampal slices." | 7.72 | [The influences of propofol on different kinds of brain injuries in rat brain slices]. ( Chen, HZ; Wang, ZJ; Xia, M; Xue, QS; Yu, BW, 2003) |
| "To investigate the effects of propofol combined with hypoxia on cognitive function of immature rats and the possible role of p38 pathway and tau protein in mediating such effects." | 5.48 | [Propofol combined with hypoxia induces cognitive dysfunction in immature rats ( Liu, H; Liu, Y; Sun, M; Tian, Q; Tu, S; Yu, Q; Zhang, J, 2018) |
| " Late awakening was more frequent with midazolam (58% vs 45%) and was associated with higher rates of delirium (62% vs 39%) and unfavorable 3-months outcome (27% vs 12%; all p = 0." | 3.91 | Late Awakening in Survivors of Postanoxic Coma: Early Neurophysiologic Predictors and Association With ICU and Long-Term Neurologic Recovery. ( Eckert, P; Miroz, JP; Oddo, M; Rey, A; Rossetti, AO, 2019) |
| "To investigate the effects of propofol on the three kinds of brain injuries induced by metabolic disorder, neurotoxicity of excitatory amino acid, and oxygen-derived free radicals in rat cerebral cortical and hippocampal slices." | 3.72 | [The influences of propofol on different kinds of brain injuries in rat brain slices]. ( Chen, HZ; Wang, ZJ; Xia, M; Xue, QS; Yu, BW, 2003) |
| "To investigate the effects of propofol combined with hypoxia on cognitive function of immature rats and the possible role of p38 pathway and tau protein in mediating such effects." | 1.48 | [Propofol combined with hypoxia induces cognitive dysfunction in immature rats ( Liu, H; Liu, Y; Sun, M; Tian, Q; Tu, S; Yu, Q; Zhang, J, 2018) |
| "Propofol treatment delayed the elimination of OPS and improved the recovery of OPS; decreased frequency of HIP, postponed the onset of HIP and increased the duration of HIP." | 1.40 | An in vitro study of the neuroprotective effect of propofol on hypoxic hippocampal slice. ( Ding, HZ; Jiang, S; Tang, QF; Zeng, YM; Zhang, DX, 2014) |
| "Pretreatment of propofol at different concentrations (50, 150, and 250 μmol/L) reversed H/R-induced neurotoxicity and increased MT-3 mRNA and protein expressions." | 1.39 | Propofol exerts hippocampal neuron protective effects via up-regulation of metallothionein-3. ( He, J; Huang, C; Jiang, J; Lv, L, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 12 (70.59) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Rey, A | 1 |
| Rossetti, AO | 2 |
| Miroz, JP | 1 |
| Eckert, P | 1 |
| Oddo, M | 2 |
| Zhang, J | 1 |
| Yu, Q | 1 |
| Liu, Y | 1 |
| Liu, H | 1 |
| Sun, M | 1 |
| Tian, Q | 1 |
| Tu, S | 2 |
| Kortelainen, J | 1 |
| Väyrynen, E | 1 |
| Juuso, I | 1 |
| Laurila, J | 1 |
| Koskenkari, J | 1 |
| Ala-Kokko, T | 1 |
| Dulin, JD | 1 |
| Noreika, DM | 1 |
| Coyne, PJ | 1 |
| Zhang, DX | 1 |
| Ding, HZ | 1 |
| Jiang, S | 1 |
| Zeng, YM | 1 |
| Tang, QF | 1 |
| Sabharwal, V | 1 |
| Ramsay, E | 1 |
| Martinez, R | 1 |
| Shumate, R | 1 |
| Khan, F | 1 |
| Dave, H | 1 |
| Iwuchukwu, I | 1 |
| McGrade, H | 1 |
| Ružman, T | 1 |
| Šimurina, T | 1 |
| Gulam, D | 1 |
| Ružman, N | 1 |
| Miškulin, M | 1 |
| Liaudet, L | 1 |
| Kaplan, PW | 1 |
| Thömke, F | 1 |
| Weilemann, SL | 1 |
| Dippmann, C | 1 |
| Winge, S | 1 |
| Nielsen, HB | 1 |
| Fernández Suárez, FE | 1 |
| Argüelles Tamargo, L | 1 |
| González Alvarez, A | 1 |
| Wang, X | 1 |
| Yang, F | 1 |
| Chen, B | 1 |
| Wu, S | 1 |
| He, W | 1 |
| Yuan, X | 1 |
| Zhang, H | 1 |
| Chen, P | 1 |
| Wei, G | 1 |
| He, J | 1 |
| Huang, C | 1 |
| Jiang, J | 1 |
| Lv, L | 1 |
| Jeong, H | 1 |
| Lee, SH | 1 |
| Jang, EA | 1 |
| Chung, SS | 1 |
| Lee, J | 1 |
| Yoo, KY | 1 |
| Yu, BW | 1 |
| Xue, QS | 1 |
| Xia, M | 1 |
| Wang, ZJ | 1 |
| Chen, HZ | 1 |
| Sasaki, R | 1 |
| Hirota, K | 1 |
| Roth, SH | 1 |
| Yamazaki, M | 1 |
| De La Cruz, JP | 1 |
| Villalobos, MA | 1 |
| Sedeño, G | 1 |
| Sánchez De La Cuesta, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of EEG Slow Wave Activity in Comatose Cardiac Arrest Survivors Under Propofol Anesthesia[NCT04506788] | 25 participants (Actual) | Observational | 2015-06-15 | Completed | |||
| Assessment of EEG Changes During Induction of Propofol Anesthesia Using Wireless Measurement Devices[NCT03943745] | 50 participants (Anticipated) | Observational | 2018-10-25 | Recruiting | |||
| A Comparison of Cerebral Oximetry After Propofol-Based Total Intravenous Anesthesia and Sevoflurane Inhalation Anesthesia in Morbidly Obese Patients Undergoing LSG: a Prospective, Single-Blinded, Randomized, Parallel-Group Study.[NCT03946657] | Phase 4 | 60 participants (Actual) | Interventional | 2019-01-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for propofol and Anoxia, Brain
| Article | Year |
|---|---|
Sevoflurane preserves regional cerebral oxygen saturation better than propofol: Randomized controlled trial.
Topics: Adult; Aged; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Pressure; | 2017 |
16 other studies available for propofol and Anoxia, Brain
| Article | Year |
|---|---|
Late Awakening in Survivors of Postanoxic Coma: Early Neurophysiologic Predictors and Association With ICU and Long-Term Neurologic Recovery.
Topics: Aged; Cohort Studies; Coma; Delirium; Electroencephalography; Evoked Potentials, Motor; Female; Hear | 2019 |
[Propofol combined with hypoxia induces cognitive dysfunction in immature rats
Topics: Animals; Cognitive Dysfunction; Hippocampus; Hypnotics and Sedatives; Hypoxia, Brain; MAP Kinase Sig | 2018 |
Forehead electrodes sufficiently detect propofol-induced slow waves for the assessment of brain function after cardiac arrest.
Topics: Algorithms; Brain; Electrodes; Electroencephalography; Equipment Design; Forehead; Heart Arrest; Hum | 2020 |
Forehead electrodes sufficiently detect propofol-induced slow waves for the assessment of brain function after cardiac arrest.
Topics: Algorithms; Brain; Electrodes; Electroencephalography; Equipment Design; Forehead; Heart Arrest; Hum | 2020 |
Forehead electrodes sufficiently detect propofol-induced slow waves for the assessment of brain function after cardiac arrest.
Topics: Algorithms; Brain; Electrodes; Electroencephalography; Equipment Design; Forehead; Heart Arrest; Hum | 2020 |
Forehead electrodes sufficiently detect propofol-induced slow waves for the assessment of brain function after cardiac arrest.
Topics: Algorithms; Brain; Electrodes; Electroencephalography; Equipment Design; Forehead; Heart Arrest; Hum | 2020 |
Management of refractory status epilepticus in an actively dying patient.
Topics: Aged; Anesthetics, Intravenous; Female; Humans; Hypoxia, Brain; Male; Middle Aged; Out-of-Hospital C | 2014 |
An in vitro study of the neuroprotective effect of propofol on hypoxic hippocampal slice.
Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Hypoxia, Brain; In Vitro Techniques; N | 2014 |
Propofol-ketamine combination therapy for effective control of super-refractory status epilepticus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthetics, Dissociative; Anesthetics, Intravenous; Chi | 2015 |
Predictors of awakening from postanoxic status epilepticus after therapeutic hypothermia.
Topics: Aged; Anticonvulsants; Benzodiazepines; Brain Stem; Cerebral Cortex; Cohort Studies; Consciousness; | 2009 |
Poor prognosis despite successful treatment of postanoxic generalized myoclonus.
Topics: Adult; Aged; Aged, 80 and over; Coma; Electroencephalography; Female; Humans; Hypoxia, Brain; Male; | 2010 |
Severe cerebral desaturation during shoulder arthroscopy in the beach-chair position.
Topics: Anesthesia, General; Arthroscopy; Blood Gas Monitoring, Transcutaneous; Brain Ischemia; Cerebrovascu | 2010 |
[Changes in the bispectral index during heart arrest and extracorporeal circulation].
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Aortic Valve Insufficiency; Cerebrovascul | 2011 |
Propofol induces neuronal apoptosis in infant rat brain under hypoxic conditions.
Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Apoptosis; Brain; Hippocampus; Humans; Hypoxia, | 2011 |
Propofol exerts hippocampal neuron protective effects via up-regulation of metallothionein-3.
Topics: Animals; Cell Death; Cell Survival; Cells, Cultured; Hippocampus; Hypoxia, Brain; Metallothionein 3; | 2013 |
Haemodynamics and cerebral oxygenation during arthroscopic shoulder surgery in beach chair position under general anaesthesia.
Topics: Aged; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; | 2012 |
[The influences of propofol on different kinds of brain injuries in rat brain slices].
Topics: Animals; Brain; Brain Injuries; Cerebral Cortex; Dose-Response Relationship, Drug; Free Radical Scav | 2003 |
Anoxic depolarization of rat hippocampal slices is prevented by thiopental but not by propofol or isoflurane.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; Evoked | 2005 |
Effect of propofol on oxidative stress in an in vitro model of anoxia-reoxygenation in the rat brain.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Free Radical Scavengers; Glutathione; Glutathione | 1998 |