Page last updated: 2024-11-03

propofol and Amentia

propofol has been researched along with Amentia in 4 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Research Excerpts

ExcerptRelevanceReference
"Patients suffering from Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies can be treated well with the cholinesterase inhibitors rivastigmine or donepezil, and because of the increasing number of these patients undergoing surgery in general anaesthesia we find it urgent to draw attention to possible complications such as severe bradycardia or third-degree heart block when propofol and remifentanil are being used."3.81[Severe bradycardia in general anaesthesia in a patient treated with cholinesterase inhibitors for dementia]. ( Ferguson, AH; Jellinge, ME, 2015)
"Patients with Huntington's disease develop a progressive but variable dementia."2.40Huntington's disease: review and anesthetic case management. ( Cangemi, CF; Miller, RJ, 1998)
"Patients with dementia are thought to be more sensitive to anesthesia, although volatile anesthetic requirement has not specifically been evaluated in this population."1.40Sensitivity to volatile anesthetics in patients with dementia: a case-control analysis. ( Dalton, JE; Geube, M; Kurz, A; Ontaneda, D; Perez-Protto, S; Sessler, DI, 2014)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Perez-Protto, S1
Geube, M1
Ontaneda, D1
Dalton, JE1
Kurz, A1
Sessler, DI1
Jellinge, ME1
Ferguson, AH1
Ho, AM1
Karmakar, MK1
Cangemi, CF1
Miller, RJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective, Randomized, Blinded, Controlled Study Evaluating the Efficacy of Continuous Lumbar Plexus Block With and Without Parasacral Block in Patients Undergoing Total Hip Replacement[NCT02161484]10 participants (Actual)Interventional2014-01-31Terminated (stopped due to The computer is crushed and all data is lost (IT was not able to recover it. Last data was collected 6.17.14))
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Incidence of Complications (e.g. Frequency of Foot-drop).

"Complications such as drug toxicity, arrhythmia, bradycardia, hematoma, Foot Drop, allergic reaction will be recorded" (NCT02161484)
Timeframe: 48 hours after the start of the surgery

InterventionNumber of complications (Number)
Continuous Lumbar Plexus Block With Parasacral Nerve Block0
Lumbar Plexus Nerve Block0

Numeric Rating Scale (NRS) Pain Assessment

Postoperative pain assessments using a 11-point numerical rating during physical therapy and at rest. This pain scale ranges from 0, being no pain at all, up to 10 being the worst pain ever experience. (NCT02161484)
Timeframe: 24 hours after the start of surgery

,
Interventionunits on a scale (Mean)
Pain at RestPain with Movement
Continuous Lumbar Plexus Block With Parasacral Nerve Block4.257.25
Lumbar Plexus Nerve Block2.24.4

Numeric Rating Scale (NRS) Pain Assessment

Postoperative pain assessments using a 11-point numerical rating during physical therapy and at rest. This pain scale ranges from 0, being no pain at all, up to 10 being the worst pain ever experience. (NCT02161484)
Timeframe: 48 hours after the start of surgery

,
Interventionunits on a scale (Mean)
Pain at RestPain with Movement
Continuous Lumbar Plexus Block With Parasacral Nerve Block18
Lumbar Plexus Nerve Block25

Numeric Rating Scale (NRS) Pain Assessment

Postoperative pain assessments using a 11-point numerical rating during physical therapy and at rest. This pain scale ranges from 0, being no pain at all, up to 10 being the worst pain ever experience. (NCT02161484)
Timeframe: 6 hours after the start of surgery

,
Interventionunits on a scale (Mean)
Pain at RestPain with Movement
Continuous Lumbar Plexus Block With Parasacral Nerve Block2.63.5
Lumbar Plexus Nerve Block3.65

Reviews

1 review available for propofol and Amentia

ArticleYear
Huntington's disease: review and anesthetic case management.
    Anesthesia progress, 1998,Fall, Volume: 45, Issue:4

    Topics: Aged; Analgesics, Opioid; Anesthesia, Dental; Anesthesia, General; Anesthetics, Inhalation; Anesthet

1998

Other Studies

3 other studies available for propofol and Amentia

ArticleYear
Sensitivity to volatile anesthetics in patients with dementia: a case-control analysis.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2014, Volume: 61, Issue:7

    Topics: Aged; Aged, 80 and over; Anesthesia, General; Anesthetics, Inhalation; Case-Control Studies; Conscio

2014
[Severe bradycardia in general anaesthesia in a patient treated with cholinesterase inhibitors for dementia].
    Ugeskrift for laeger, 2015, Feb-09, Volume: 177, Issue:7

    Topics: Aged; Anesthesia, General; Anesthetics, Intravenous; Bradycardia; Cholinesterase Inhibitors; Dementi

2015
Combined paravertebral lumbar plexus and parasacral sciatic nerve block for reduction of hip fracture in a patient with severe aortic stenosis.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2002, Volume: 49, Issue:9

    Topics: Aged; Aged, 80 and over; Anesthesia, Spinal; Anesthetics, Intravenous; Aortic Valve Stenosis; Dement

2002