propofol has been researched along with Aging in 92 studies
Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This pilot study established a system to compare effects of different anesthetics and generated a hypothesis that propofol trended to have a higher incidence and had longer duration of postoperative delirium than sevoflurane." | 9.34 | The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study. ( Li, C; Ma, X; Marcantonio, E; Mei, X; Shen, Y; Xie, Z; Zheng, H; Zheng, HL, 2020) |
| "To determine the combined effects of aging and propofol on autonomic nervous system activity using heart rate variability (HRV) analysis." | 9.17 | Effects of aging and propofol on the cardiovascular component of the autonomic nervous system. ( El Beheiry, H; Mak, P, 2013) |
| "This study showed that older patients require less metoclopramide, with venous occlusion for 1 minute, to reduce pain on injection of propofol than do younger patients." | 9.12 | Age-related differences in metoclopramide requirement for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006) |
| "Pain during injection of propofol was evaluated." | 9.12 | Influence of aging on lidocaine requirements for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006) |
| "There is disagreement about allowing propofol sedation for research magnetic resonance imaging/spectroscopy (MRI/MRS) in children." | 9.11 | Propofol sedation for longitudinal pediatric neuroimaging research. ( Amundsen, LB; Artru, AA; Dager, SR; Dawson, G; Friedman, S; Shaw, DW; Sparks, B, 2005) |
| "Clonidine premedication augments the pressor and tachycardiac responses to ephedrine in elderly patients during standard or large doses of propofol anesthesia but does not augment during small doses of propofol anesthesia." | 9.10 | The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia. ( Ishiyama, T; Kashimoto, S; Kumazawa, T; Matsukawa, T; Oguchi, T, 2003) |
| "Propofol pretreatment increased MCh relaxation in arteries from captopril-treated compared with untreated rats (P = 0." | 5.39 | Propofol increases vascular relaxation in aging rats chronically treated with the angiotensin-converting enzyme inhibitor captopril. ( Bourque, SL; Davidge, ST; Gragasin, FS, 2013) |
| " We hypothesized that propofol increases nitric oxide (NO)-mediated vasodilation by enhancing its bioavailability in the aged adult vasculature, leading to greater vasodilation than in the young adult." | 5.35 | The effects of propofol on vascular function in mesenteric arteries of the aging rat. ( Davidge, ST; Gragasin, FS, 2009) |
| "This pilot study established a system to compare effects of different anesthetics and generated a hypothesis that propofol trended to have a higher incidence and had longer duration of postoperative delirium than sevoflurane." | 5.34 | The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study. ( Li, C; Ma, X; Marcantonio, E; Mei, X; Shen, Y; Xie, Z; Zheng, H; Zheng, HL, 2020) |
| "This study showed that older patients require less metoclopramide, with venous occlusion for 1 minute, to reduce pain on injection of propofol than do younger patients." | 5.12 | Age-related differences in metoclopramide requirement for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006) |
| "Pain during injection of propofol was evaluated." | 5.12 | Influence of aging on lidocaine requirements for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006) |
| "There is disagreement about allowing propofol sedation for research magnetic resonance imaging/spectroscopy (MRI/MRS) in children." | 5.11 | Propofol sedation for longitudinal pediatric neuroimaging research. ( Amundsen, LB; Artru, AA; Dager, SR; Dawson, G; Friedman, S; Shaw, DW; Sparks, B, 2005) |
| "Infants and children undergoing magnetic resonance imaging with propofol sedation had determinations of the transverse and anterior-posterior (AP) dimensions of the larynx at the most cephalad level of the larynx (vocal cords) and the most caudad level (cricoid)." | 5.10 | Developmental changes of laryngeal dimensions in unparalyzed, sedated children. ( Litman, RS; Shibata, D; Weissend, EE; Westesson, PL, 2003) |
| "Clonidine premedication augments the pressor and tachycardiac responses to ephedrine in elderly patients during standard or large doses of propofol anesthesia but does not augment during small doses of propofol anesthesia." | 5.10 | The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia. ( Ishiyama, T; Kashimoto, S; Kumazawa, T; Matsukawa, T; Oguchi, T, 2003) |
| " The aging rat model was established by continuous 200 mg/kg propofol anesthesia." | 4.31 | Avenanthramide-C Activates Nrf2/ARE Pathway and Inhibiting Ferroptosis Pathway to Improve Cognitive Dysfunction in Aging Rats. ( Cao, X; Ma, Y; Ma, Z; Song, T; Zhang, Y, 2023) |
| "The relationship between the pharmacokinetic parameters of propofol obtained in rats, children and adults was analyzed by plotting the logarithmically transformed parameters against the corresponding logarithmically transformed body weights." | 3.73 | Allometric relationships between the pharmacokinetics of propofol in rats, children and adults. ( Aarts, LP; Danhof, M; Knibbe, CA; Kuks, PF; Zuideveld, KP, 2005) |
| "Fifty patients more than 70 years old, ASA I and II, NYHA I and II, were anaesthetized by propofol for cataract or retinal detachment surgery." | 3.68 | [Propofol anesthesia for ophthalmologic surgery in the elderly]. ( Dandoy, M; Lampl, E; Maurin, JP; Poisson, F; Reynaud, S, 1992) |
| "Propofol was continuously infused during surgery and spinal anesthesia in 15 elderly patients (65-85 yr-old) and 15 younger patients (20-50 yr-old)." | 2.70 | Recovery of psychomotor function after propofol sedation is prolonged in the elderly. ( Kitajima, T; Okuda, Y; Shinozaki, M; Usui, Y; Yamaguchi, S, 2002) |
| "Midazolam pretreatment was associated with a significant reduction in propofol dose requirement in both younger and older patients." | 2.70 | Effect of midazolam pretreatment on induction dose requirements of propofol in combination with fentanyl in younger and older adults. ( Bhaskaran, NC; Claydon, P; Cressey, DM; Reilly, CS, 2001) |
| "Rapacuronium is an investigational nondepolarizing relaxant that also has a rapid onset and short duration and consequently should be compared with succinylcholine in its ability to facilitate rapid tracheal intubation." | 2.69 | Comparison of the intubation conditions provided by rapacuronium (ORG 9487) or succinylcholine in humans during anesthesia with fentanyl and propofol. ( Caldwell, JE; Chan, V; Chung, F; Cicutti, N; Fleming, NW; Gan, TJ; Glass, PS; Gronert, GA; Kirkegaard-Nielsen, H; Kitts, JB, 1999) |
| " Population pharmacokinetic modeling was performed using NONMEM (NONMEM Project Group, University of California, San Francisco, CA)." | 2.69 | Population pharmacokinetics of propofol: a multicenter study. ( Ihmsen, H; Schüttler, J, 2000) |
| "The propofol requirements were significantly less in the midazolam-fentanyl groups, regardless of age, and among the premedicated patients older than 60 yr compared with the other age groups." | 2.69 | The combined effect of age and premedication on the propofol requirements for induction by target-controlled infusion. ( Ballester, JA; Elizalde, JL; Escobar, A; Olmos, M; Vidarte, MA, 2000) |
| " The dosage was calculated from the infusion time (time from start of infusion until specific clinical event)." | 2.68 | [Age-related correlation between EEG parameters and depth of anesthesia under propofol. Effect of fentanyl]. ( Eckert, O; Lehmkuhl, P; Neulinger, A; Pichlmayr, I; Werry, C, 1996) |
| " On the basis of pharmacokinetic-pharmacodynamic modelling, a mean blood-brain equilibration half-life of only 2." | 2.38 | Pharmacokinetic implications for the clinical use of propofol. ( Gepts, E; Kanto, J, 1989) |
| " We proposed 5 different models consisting of different combinations of potential contributing factors associated with burst suppression: (1) a Base Model consisting of alpha power; (2) an Extended Mechanistic Model consisting of alpha power, age, and drug dosing information; (3) a Clinical Confounding Factors Model consisting of alpha power, hypotension, and other confounds; (4) a Simplified Model consisting only of alpha power and propofol bolus administration; and (5) a Full Model consisting of all of these variables to control for as much confounding as possible." | 1.56 | Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a "Vulnerable Brain". ( Brown, EN; Colvin, C; Deng, H; Dickerson, BC; Houle, TT; Kahali, P; Purdon, PL; Shao, YR, 2020) |
| "Propofol was added intraperitoneally to the mice from 7th day of insulin/saline treatment, and general anesthesia was induced and maintained for 2 hours/day for 5 consecutive days." | 1.51 | Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice. ( Huang, F; Ke, D; Li, X; Liang, Z; Liu, R; Run, X; Wang, JZ; Wang, Q; Wang, X; Wei, Z; Zeng, K; Zhang, B, 2019) |
| "No significant decrease in dosing between age groups was observed for fentanyl and midazolam." | 1.43 | Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice. ( Akhtar, S; Burg, MM; Dai, F; Heng, J; Liu, J; Schonberger, RB, 2016) |
| "When methylphenidate was administered after propofol, the mean time to emergence decreased to 6." | 1.42 | Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain. ( Brown, EN; Chemali, JJ; Kenny, JD; Kimchi, EY; Olutola, O; Purdon, PL; Solt, K; Taylor, NE, 2015) |
| "Propofol was administrated to the WT and AD Tg mice once a week for 8 or 12 weeks, respectively." | 1.40 | Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice. ( Dong, Y; Shao, H; Xia, W; Xie, Z; Yu, B; Zhang, Y, 2014) |
| "Propofol caused an increase in GluA1 phosphorylation in the hippocampus but not in the prefrontal cortex." | 1.40 | Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice. ( Fibuch, EE; Hastings, JM; Mao, LM; Wang, JQ, 2014) |
| "Propofol pretreatment increased MCh relaxation in arteries from captopril-treated compared with untreated rats (P = 0." | 1.39 | Propofol increases vascular relaxation in aging rats chronically treated with the angiotensin-converting enzyme inhibitor captopril. ( Bourque, SL; Davidge, ST; Gragasin, FS, 2013) |
| "The isoflurane anaesthesia treatment increased the escape latency contrast to propofol anaesthesia group." | 1.38 | Changes of learning and memory in aged rats after isoflurane inhalational anaesthesia correlated with hippocampal acetylcholine level. ( Feng, C; Jia, X; Wang, H; Wang, Y; Wu, A; Xu, Z; Yue, Y, 2012) |
| " We hypothesized that propofol increases nitric oxide (NO)-mediated vasodilation by enhancing its bioavailability in the aged adult vasculature, leading to greater vasodilation than in the young adult." | 1.35 | The effects of propofol on vascular function in mesenteric arteries of the aging rat. ( Davidge, ST; Gragasin, FS, 2009) |
| "/st> Propofol clearance is lower in neonates than in adults and displays extensive interindividual variability, in part explained by postmenstrual age (PMA) and postnatal age (PNA)." | 1.35 | Urinary propofol metabolites in early life after single intravenous bolus. ( Allegaert, K; Cossey, V; de Hoon, J; Naulaers, G; Rayyan, M; Vancraeynest, J; Verbesselt, R, 2008) |
| "As propofol is a GABAA agonist, we hypothesized that it and more specific GABAA modulators would increase intracellular free calcium ([Ca2+]i), resulting in the death of neonatal rat hippocampal neurons." | 1.35 | GABAergic mechanism of propofol toxicity in immature neurons. ( Fiskum, G; Kahraman, S; McCarthy, MM; Zup, SL, 2008) |
| "Propofol has different receptor mechanisms of action and a favorable short-term recovery profile, and it has been proposed that propofol is devoid of enduring effects on cognitive performance." | 1.35 | Spatial memory is intact in aged rats after propofol anesthesia. ( Baxter, MG; Crosby, G; Culley, DJ; Lee, IH; Tanzi, RE; Xie, Z, 2008) |
| " The pharmacodynamic parameters were estimated by non-linear regression analysis." | 1.35 | Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children. ( Ammon, C; Fechner, J; Ihmsen, H; Jeleazcov, C; Schmidt, J; Schüttler, J; Schwilden, H, 2008) |
| " Statistically significant multivariate predictors of hypotension 0-10 min after anesthetic induction included: ASA III-V, baseline MAP <70 mm Hg, age > or =50 yr, the use of propofol for induction of anesthesia, and increasing induction dosage of fentanyl." | 1.33 | Predictors of hypotension after induction of general anesthesia. ( Baez, B; Bernstein, A; Bodian, CA; Hossain, S; Krol, M; Patel, P; Reich, DL, 2005) |
| "This study supports the case that the pharmacokinetic properties of propofol do not differ substantially across Chinese children of different ages after weight has been accounted for." | 1.33 | Pharmacokinetics of a single bolus of propofol in chinese children of different ages. ( Aarons, L; Chen, X; Freemantle, N; Lian, Q; Matthews, I; Shangguan, WN; Smith, FG; Wang, Z, 2006) |
| "Propofol was then given as an IV bolus of 4." | 1.33 | Autonomic mechanisms in the age-related hypotensive effect of propofol. ( Heerdt, PM; Memtsoudis, SG; The, AHS, 2005) |
| "Propofol in KH was perfused at 12 microg/ml for the first 15 min of reperfusion and subsequently reduced to 5 microg/ml in propofol treatment groups." | 1.32 | Propofol enhances ischemic tolerance of middle-aged rat hearts: effects on 15-F(2t)-isoprostane formation and tissue antioxidant capacity. ( Ansley, DM; Godin, DV; Xia, Z, 2003) |
| "To simulate the time course of drug effect, it is sometimes necessary to combine the pharmacodynamic parameters from an integrated pharmacodynamic-pharmacodynamic study (e." | 1.32 | Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics. ( Gregg, KM; Henthorn, TK; Minto, CF; Schnider, TW; Shafer, SL, 2003) |
| " To increase our insight into the pharmacokinetics of propofol in this patient population and to obtain pharmacokinetic parameters applicable in target controlled infusion (TCI), the pharmacokinetics of propofol during and after continuous infusion were studied in 31 ASA class 1 and 2 patients, aged 65-91 yr, scheduled for general surgery." | 1.31 | Gender differences in the pharmacokinetics of propofol in elderly patients during and after continuous infusion. ( Bovill, JG; Burm, AG; Oostwouder, CJ; Vletter, AA; Vuyk, J, 2001) |
| "Propofol was more potent in the younger animals (EC(50), 5." | 1.31 | Direct effects of propofol on myocardial and vascular tissue from mature and immature rats. ( Lundell, JC; Neville, MJ; Ririe, DG, 2001) |
| "A retrospective study was performed to determine the influence of age on hemodynamics and awakening time in total intravenous anesthesia (TIVA) using propofol and buprenorphine combined with continuous epidural anesthesia for abdominal surgery." | 1.31 | [The influence of age on hemodynamics and the dose requirements of propofol and buprenorphine in total intravenous anesthesia combined with continuous epidural anesthesia]. ( Tabuchi, Y, 2001) |
| " These data contrast with other studies in which dosage was based on total body mass where a decrease in dose requirement with age was demonstrated." | 1.28 | Lean tissue mass is a useful predictor of induction dose requirements for propofol. ( Crankshaw, DP; Leslie, K, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.17) | 18.7374 |
| 1990's | 17 (18.48) | 18.2507 |
| 2000's | 40 (43.48) | 29.6817 |
| 2010's | 25 (27.17) | 24.3611 |
| 2020's | 8 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, Z | 1 |
| Ma, Y | 1 |
| Cao, X | 1 |
| Zhang, Y | 2 |
| Song, T | 1 |
| Dahaba, AA | 1 |
| Xiao, Z | 1 |
| Zhu, X | 1 |
| Dong, H | 1 |
| Xiong, L | 1 |
| Rehak, P | 1 |
| Zelzer, S | 1 |
| Wang, K | 1 |
| Reibnegger, G | 1 |
| Crofts, A | 1 |
| Trotman-Lucas, M | 1 |
| Janus, J | 1 |
| Kelly, M | 1 |
| Gibson, CL | 1 |
| Mei, X | 1 |
| Zheng, HL | 1 |
| Li, C | 1 |
| Ma, X | 1 |
| Zheng, H | 1 |
| Marcantonio, E | 1 |
| Xie, Z | 3 |
| Shen, Y | 2 |
| Shao, YR | 1 |
| Kahali, P | 1 |
| Houle, TT | 1 |
| Deng, H | 1 |
| Colvin, C | 1 |
| Dickerson, BC | 1 |
| Brown, EN | 3 |
| Purdon, PL | 3 |
| Liu, PF | 1 |
| Gao, T | 1 |
| Li, TZ | 1 |
| Yang, YT | 1 |
| Xu, YX | 1 |
| Xu, ZP | 1 |
| Mi, WD | 1 |
| Linassi, F | 1 |
| Kreuzer, M | 1 |
| Maran, E | 1 |
| Farnia, A | 1 |
| Zanatta, P | 1 |
| Navalesi, P | 1 |
| Carron, M | 1 |
| Matsuki, Y | 1 |
| Nagata, O | 1 |
| Ogino, Y | 1 |
| Shigemi, K | 1 |
| Li, X | 1 |
| Run, X | 1 |
| Wei, Z | 1 |
| Zeng, K | 1 |
| Liang, Z | 1 |
| Huang, F | 1 |
| Ke, D | 1 |
| Wang, Q | 1 |
| Wang, JZ | 1 |
| Liu, R | 1 |
| Zhang, B | 1 |
| Wang, X | 1 |
| Boroujerdi Alavi, M | 1 |
| Tabatabaei, M | 1 |
| Gragasin, FS | 2 |
| Bourque, SL | 1 |
| Davidge, ST | 2 |
| Lacoh, CM | 1 |
| Bodogan, T | 1 |
| Kaila, K | 1 |
| Fiumelli, H | 1 |
| Vutskits, L | 2 |
| Erasso, DM | 2 |
| Camporesi, EM | 2 |
| Mangar, D | 1 |
| Saporta, S | 2 |
| El Beheiry, H | 1 |
| Mak, P | 1 |
| Shao, H | 1 |
| Dong, Y | 1 |
| Yu, B | 1 |
| Xia, W | 1 |
| Eleveld, DJ | 1 |
| Proost, JH | 1 |
| Cortínez, LI | 1 |
| Absalom, AR | 1 |
| Struys, MM | 1 |
| Mao, LM | 1 |
| Hastings, JM | 1 |
| Fibuch, EE | 1 |
| Wang, JQ | 1 |
| Sakai, Y | 1 |
| Kawahito, S | 1 |
| Takaishi, K | 1 |
| Mita, N | 1 |
| Kinoshita, H | 1 |
| Hatakeyama, N | 1 |
| Azma, T | 1 |
| Nakaya, Y | 1 |
| Kitahata, H | 1 |
| Li, M | 1 |
| Zhang, X | 1 |
| Wu, A | 2 |
| Wang, Z | 2 |
| Li, J | 1 |
| Yue, Y | 2 |
| Pavone, KJ | 1 |
| Akeju, O | 1 |
| Smith, AC | 1 |
| Sampson, AL | 1 |
| Lee, J | 1 |
| Zhou, DW | 1 |
| Solt, K | 2 |
| Chemali, JJ | 1 |
| Kenny, JD | 1 |
| Olutola, O | 1 |
| Taylor, NE | 1 |
| Kimchi, EY | 1 |
| Akhtar, S | 1 |
| Liu, J | 1 |
| Heng, J | 1 |
| Dai, F | 1 |
| Schonberger, RB | 1 |
| Burg, MM | 1 |
| Osthaus, WA | 1 |
| Lee, IH | 1 |
| Culley, DJ | 1 |
| Baxter, MG | 1 |
| Tanzi, RE | 1 |
| Crosby, G | 1 |
| Kahraman, S | 1 |
| Zup, SL | 1 |
| McCarthy, MM | 1 |
| Fiskum, G | 1 |
| Allegaert, K | 3 |
| Vancraeynest, J | 1 |
| Rayyan, M | 1 |
| de Hoon, J | 1 |
| Cossey, V | 1 |
| Naulaers, G | 2 |
| Verbesselt, R | 2 |
| Lysakowski, C | 2 |
| Elia, N | 1 |
| Czarnetzki, C | 2 |
| Dumont, L | 1 |
| Haller, G | 1 |
| Combescure, C | 1 |
| Tramèr, MR | 2 |
| Lee, BJ | 1 |
| Yi, JW | 1 |
| Chung, JY | 1 |
| Kim, DO | 1 |
| Kang, JM | 1 |
| McCormack, J | 1 |
| Mehta, D | 1 |
| Peiris, K | 1 |
| Dumont, G | 1 |
| Fung, P | 1 |
| Lim, J | 1 |
| Ansermino, JM | 1 |
| Büttner, N | 1 |
| Schultz, B | 2 |
| Grouven, U | 2 |
| Schultz, A | 2 |
| Miki, S | 1 |
| Matsumoto, K | 1 |
| Fudickar, A | 1 |
| Voss, D | 1 |
| Serocki, G | 1 |
| Jeckström, W | 1 |
| Ambrosch, P | 1 |
| Steinfath, M | 1 |
| Bein, B | 1 |
| Jeong, CW | 1 |
| Ju, J | 1 |
| Lee, DW | 1 |
| Lee, SH | 1 |
| Yoon, MH | 1 |
| Aimé, I | 1 |
| Gayat, E | 1 |
| Fermanian, C | 1 |
| Cook, F | 1 |
| Peuch, C | 1 |
| Laloë, PA | 1 |
| Mantz, J | 3 |
| Fischler, M | 1 |
| Wang, C | 1 |
| Peeters, MY | 2 |
| Blussé van Oud-Alblas, HJ | 1 |
| Krekels, EH | 1 |
| Tibboel, D | 2 |
| Danhof, M | 2 |
| Knibbe, CA | 3 |
| Chaparro, RE | 1 |
| Quiroga Del Rio, CE | 1 |
| Karlnoski, R | 1 |
| Wang, H | 1 |
| Xu, Z | 1 |
| Feng, C | 1 |
| Wang, Y | 1 |
| Jia, X | 1 |
| Constant, I | 1 |
| Sabourdin, N | 1 |
| Soltész, S | 1 |
| Silomon, M | 1 |
| Mencke, T | 1 |
| Schlaich, N | 1 |
| Fuchs-Buder, T | 1 |
| Tabuchi, Y | 3 |
| Shinozaki, M | 1 |
| Usui, Y | 1 |
| Yamaguchi, S | 1 |
| Okuda, Y | 1 |
| Kitajima, T | 1 |
| Litman, RS | 1 |
| Weissend, EE | 1 |
| Shibata, D | 1 |
| Westesson, PL | 1 |
| Ishiyama, T | 1 |
| Kashimoto, S | 1 |
| Oguchi, T | 1 |
| Matsukawa, T | 1 |
| Kumazawa, T | 1 |
| Ouattara, A | 1 |
| Boccara, G | 1 |
| Lemaire, S | 1 |
| Köckler, U | 1 |
| Landi, M | 1 |
| Vaissier, E | 1 |
| Léger, P | 1 |
| Coriat, P | 1 |
| Xia, Z | 1 |
| Godin, DV | 1 |
| Ansley, DM | 1 |
| Minto, CF | 2 |
| Schnider, TW | 2 |
| Gregg, KM | 1 |
| Henthorn, TK | 1 |
| Shafer, SL | 2 |
| Eilers, H | 1 |
| Niemann, C | 1 |
| Zander, I | 1 |
| Beger, FA | 1 |
| Siedenberg, M | 1 |
| O'Halloran, PL | 1 |
| Hosseini-Yeganeh, M | 1 |
| McBride, LJ | 1 |
| Ramzan, I | 1 |
| Memtsoudis, SG | 1 |
| The, AHS | 1 |
| Heerdt, PM | 1 |
| Kreuer, S | 1 |
| Schreiber, JU | 1 |
| Bruhn, J | 1 |
| Wilhelm, W | 1 |
| Zuideveld, KP | 1 |
| Aarts, LP | 1 |
| Kuks, PF | 1 |
| Reich, DL | 1 |
| Hossain, S | 1 |
| Krol, M | 1 |
| Baez, B | 1 |
| Patel, P | 1 |
| Bernstein, A | 1 |
| Bodian, CA | 1 |
| Amundsen, LB | 1 |
| Artru, AA | 1 |
| Dager, SR | 1 |
| Shaw, DW | 1 |
| Friedman, S | 1 |
| Sparks, B | 1 |
| Dawson, G | 1 |
| Shangguan, WN | 1 |
| Lian, Q | 1 |
| Aarons, L | 1 |
| Matthews, I | 1 |
| Chen, X | 1 |
| Freemantle, N | 1 |
| Smith, FG | 1 |
| Fujii, Y | 2 |
| Shiga, Y | 2 |
| Li, Y | 1 |
| Zhu, S | 1 |
| Hahn, RG | 1 |
| de Hoon, JN | 1 |
| Jeleazcov, C | 2 |
| Schmidt, J | 2 |
| Schmitz, B | 1 |
| Becke, K | 1 |
| Albrecht, S | 1 |
| Tirel, O | 1 |
| Wodey, E | 1 |
| Harris, R | 1 |
| Bansard, JY | 1 |
| Ecoffey, C | 1 |
| Senhadji, L | 1 |
| Ihmsen, H | 2 |
| Ammon, C | 1 |
| Schwilden, H | 1 |
| Schüttler, J | 2 |
| Fechner, J | 1 |
| Jenny, B | 1 |
| Copin, JC | 1 |
| Ream, RS | 1 |
| Schreiner, MS | 1 |
| Neff, JD | 1 |
| McRae, KM | 1 |
| Jawad, AF | 1 |
| Scherer, PW | 1 |
| Neufeld, GR | 1 |
| Stieglitz, P | 1 |
| Scafuro, M | 1 |
| Cafaggi, G | 1 |
| Di Gregorio, AM | 1 |
| Petrella, F | 1 |
| Roder, JD | 1 |
| Sangiah, S | 1 |
| Larsson, JE | 2 |
| Wahlström, G | 2 |
| Reid, J | 1 |
| Nolan, AM | 1 |
| Werry, C | 1 |
| Neulinger, A | 1 |
| Eckert, O | 1 |
| Lehmkuhl, P | 1 |
| Pichlmayr, I | 1 |
| Wu, MH | 1 |
| Su, MJ | 1 |
| Sun, SS | 1 |
| Gambus, PL | 1 |
| Andresen, C | 1 |
| Goodale, DB | 1 |
| Youngs, EJ | 1 |
| Keita, H | 2 |
| Lasocki, S | 1 |
| Henzel-Rouellé, D | 1 |
| Desmonts, JM | 2 |
| Peytavin, G | 1 |
| Giraud, O | 1 |
| Silleran, J | 1 |
| Rahoeliarivaraux, L | 1 |
| Fukura, H | 1 |
| Kitani, Y | 1 |
| Komiya, Y | 1 |
| Igarashi, M | 1 |
| Fleming, NW | 1 |
| Chung, F | 1 |
| Glass, PS | 1 |
| Kitts, JB | 1 |
| Kirkegaard-Nielsen, H | 1 |
| Gronert, GA | 1 |
| Chan, V | 1 |
| Gan, TJ | 1 |
| Cicutti, N | 1 |
| Caldwell, JE | 1 |
| Olmos, M | 1 |
| Ballester, JA | 1 |
| Vidarte, MA | 1 |
| Elizalde, JL | 1 |
| Escobar, A | 1 |
| Cressey, DM | 1 |
| Claydon, P | 1 |
| Bhaskaran, NC | 1 |
| Reilly, CS | 1 |
| Münte, S | 1 |
| Münte, TF | 1 |
| Mitzlaff, B | 1 |
| Walz, R | 1 |
| Leuwer, M | 1 |
| Piepenbrock, S | 1 |
| Vuyk, J | 1 |
| Oostwouder, CJ | 1 |
| Vletter, AA | 1 |
| Burm, AG | 1 |
| Bovill, JG | 1 |
| Kudoh, A | 1 |
| Katagai, H | 1 |
| Takazawa, T | 1 |
| Matsuki, A | 1 |
| Ririe, DG | 1 |
| Lundell, JC | 1 |
| Neville, MJ | 1 |
| Dandoy, M | 1 |
| Reynaud, S | 1 |
| Poisson, F | 1 |
| Lampl, E | 1 |
| Maurin, JP | 1 |
| Westrin, P | 1 |
| Leslie, K | 1 |
| Crankshaw, DP | 1 |
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| Gepts, E | 1 |
| Kirkpatrick, T | 1 |
| Cockshott, ID | 1 |
| Douglas, EJ | 1 |
| Nimmo, WS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Age on Propofol-Bispectral Index Response Relationship Among Different Age Groups From Vicenarians to Nonagenarians. A New Logistic Model Compared With Traditional Sigmoid Emax Model[NCT02585284] | 80 participants (Actual) | Observational | 2011-09-30 | Completed | |||
| Development of a Pharmacodynamic Model for Propofol in Older Adults (Development phaRmacodynamic mOdel Propofol oLdEr adulTs: DROPLET)[NCT05790720] | 60 participants (Anticipated) | Interventional | 2023-12-01 | Not yet recruiting | |||
| Intranasal Insulin Improves Postoperative Neurocognitive Disorders in Elderly Patients: a Multicenter, Randomized, Double-blind, Placebo-controlled Study[NCT05613491] | 438 participants (Anticipated) | Interventional | 2022-11-07 | Recruiting | |||
| Study of an Intraoperative Frontal Electroencephalographic Marker of Preoperative Frailty in Patients Over 65 Years of Age for Elective Non-cardiac Surgery.[NCT04783662] | 60 participants (Actual) | Observational | 2021-05-13 | Completed | |||
| Cognitive Outcomes and Neuroimages Associated With Anesthesia-Related EEG Signatures[NCT03442179] | 24 participants (Actual) | Observational | 2019-02-13 | Active, not recruiting | |||
| The Role of Brain Wave Monitoring in Reducing the Incidence of Postoperative Cognitive Dysfunction[NCT04189861] | 100 participants (Anticipated) | Observational | 2020-01-24 | Recruiting | |||
| Relationship Between Bispectral Index, EEG Features, and Propofol Effect-site Concentration in Young and Elderly Patients.[NCT04774120] | 30 participants (Actual) | Observational | 2020-12-11 | Completed | |||
| Core Temperature Variations During Midazolam vs Propofol Sedation for Neuraxial Anesthesia[NCT02502877] | 27 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Comparison of the Bispectral Index and the Entropy of the Electroencephalogram During Total Intravenous Anesthesia[NCT00391963] | 84 participants | Observational | 2006-06-30 | Completed | |||
| EEG-based Depth of Anesthesia-monitoring During General Anesthesia - Effects on Time to Wake-up and Post-operative Cognition[NCT04529304] | 100 participants (Anticipated) | Interventional | 2021-01-08 | Recruiting | |||
| Shape and Dimensions of the Upper Airway in Infants Using Computed Tomography Imaging[NCT02925169] | 40 participants (Actual) | Observational | 2016-04-30 | Completed | |||
| Volumetric Three-dimensional Analysis of the Pediatric Upper Airway Shape Using Computed Tomography Imaging.[NCT02771171] | 60 participants (Actual) | Observational | 2016-04-30 | Completed | |||
| Comparison Between Two Endotracheal Tube Cuff Inflation Methods; Flow Volume Loop Guided vs. Just Seal by Stethoscope Guided in Pediatric Patients[NCT03902756] | 80 participants (Actual) | Interventional | 2018-06-05 | Completed | |||
| Changes of Hemodynamics and Vital Organ Function in Intracerebral Hemorrhage During Different General Anesthesia[NCT03129009] | 90 participants (Anticipated) | Interventional | 2017-04-01 | Recruiting | |||
| Fentanyl Effect on Blood Pressure in Elderly Patients After Induction of General Anesthesia[NCT02489019] | Phase 2/Phase 3 | 105 participants (Anticipated) | Interventional | 2018-02-19 | Recruiting | ||
| Focussed Echocardiography to Detect Preoperative Hypovolemia and Left Ventricular Dysfunction as a Predictor of Post-Induction Hypotension[NCT02944266] | 150 participants (Anticipated) | Observational | 2016-01-31 | Recruiting | |||
| Perfusion Index as a Predictor of Hypotension Following Propofol Induction of General Anesthesia in Geriatric Patients - A Prospective Observational Study.[NCT04682717] | 30 participants (Actual) | Observational | 2020-12-01 | Completed | |||
| Comparison of Leg Elevation and Leg Wrapping in the Prevention of Propofol Induced Hypotension: A Prospective Randomised Controlled Study[NCT02845921] | 150 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting | |||
| Effect of the Pneumatic Compression of Lower Leg on Post-induction Hypotension in Elderly Patients Undergoing Robot Assisted Laparoscopic Prostatectomy: a Double Blined Randomized Controlled Trial[NCT05343689] | 100 participants (Actual) | Interventional | 2022-05-04 | Completed | |||
| "PGDT With the Hypotension Prediction Index to Reduce the Number and Duration of Intraoperative Hypotension and the Incidence of Renal Failure in Patients Undergoing Lung Surgery"[NCT04149314] | 142 participants (Actual) | Interventional | 2019-11-20 | Completed | |||
| Compare the Side Effects and Differences Awake Level of Propofol by Using Three TCI Formula of Anesthesia in TVOR Patients[NCT00760253] | 118 participants (Actual) | Observational | 2008-09-30 | Completed | |||
| A Prospective Comparison of the Airway Deadspace Associated With the Air-Q® and Endotracheal Tube Using Volumetric Capnography in Young Children[NCT03785977] | 62 participants (Actual) | Observational | 2019-03-25 | Completed | |||
| Evaluation of the Impact of Adding Remifentanil to Propofol on the Conditions of the Diagnostic Panendoscopy of the Upper Airway Under General Anesthesia With Tubeless Spontaneous Ventilation.[NCT02093143] | Phase 3 | 256 participants (Actual) | Interventional | 2009-06-30 | Completed | ||
| Investigation on the Pharmacokinetic and -Dynamic of Propofol During Awake Craniotomy[NCT01128465] | 10 participants (Anticipated) | Observational | 2010-02-28 | Completed | |||
| Comparison of Ephedrine Versus Norepinephrine Efficacity to Correct Anesthesia Induction Related Hypotension in Chronic Renal Insufficiency Patients[NCT05497700] | Phase 3 | 60 participants (Anticipated) | Interventional | 2022-09-15 | Recruiting | ||
| Pharmacokinetic and Pharmacodynamic of Rocuronium Bromide Measured in Adductor Pollicis and Masseter Muscles.[NCT02376595] | 10 participants (Actual) | Observational | 2013-03-31 | Completed | |||
| Study of the Effect of Intraoperative Positive Messages on Postoperative Outcomes[NCT02765750] | 5 participants (Actual) | Interventional | 2016-03-31 | Terminated (stopped due to The primary investigator was transferred to another hospital) | |||
| Effect of Gender on the Pharmacokinetics-pharmacodynamics of Propofol and Cisatracurium Besylate[NCT02588118] | 120 participants (Actual) | Observational | 2010-01-31 | Completed | |||
| Neuromodulation With Percutaneous Electrical Nerve Field Stimulation for Adults With COVID-19[NCT04514627] | 100 participants (Anticipated) | Interventional | 2020-07-13 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for propofol and Aging
| Article | Year |
|---|---|
The EEG signal: a window on the cortical brain activity.
Topics: Adult; Aging; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Cerebral Cortex; Child; | 2012 |
Clinically important drug interactions with intravenous anaesthetics in older patients.
Topics: Aged; Aging; Anesthetics, Intravenous; Barbiturates; Benzodiazepines; Drug Interactions; Etomidate; | 2003 |
Pharmacokinetic implications for the clinical use of propofol.
Topics: Adult; Aged; Aging; Anesthetics; Blood Proteins; Child; Child, Preschool; Dose-Response Relationship | 1989 |
23 trials available for propofol and Aging
| Article | Year |
|---|---|
The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study.
Topics: Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intra | 2020 |
Age influences on Propofol estimated brain concentration and entropy during maintenance and at return of consciousness during total intravenous anesthesia with target-controlled infusion in unparalyzed patients: An observational prospective trial.
Topics: Aged; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Brain; Consciousness; Electroencepha | 2020 |
Effects of aging and propofol on the cardiovascular component of the autonomic nervous system.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Intravenous; Autonomic Nervous System; Blood Pre | 2013 |
[EEG-adjusted target-controlled infusion : Propofol target concentration with different doses of remifentanil].
Topics: Adult; Aged; Aging; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; B | 2010 |
Lipid-emulsion propofol less attenuates the regulation of body temperature than micro-emulsion propofol or sevoflurane in the elderly.
Topics: Aged; Aging; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intra | 2012 |
Effect of age on the comparability of bispectral and state entropy indices during the maintenance of propofol-sufentanil anaesthesia.
Topics: Age Factors; Aging; Anesthesia, General; Anesthetics, Combined; Anesthetics, Intravenous; Electroenc | 2012 |
[Neuromuscular blockade with cisatracurium in infants andchildren. Its course under sevoflurane anesthesia].
Topics: Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intrav | 2002 |
Recovery of psychomotor function after propofol sedation is prolonged in the elderly.
Topics: Adult; Aged; Aging; Anesthesia Recovery Period; Anesthesia, Spinal; Conscious Sedation; Electroencep | 2002 |
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc | 2003 |
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc | 2003 |
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc | 2003 |
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc | 2003 |
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc | 2003 |
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc | 2003 |
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc | 2003 |
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc | 2003 |
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc | 2003 |
The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adult; Aged; Aging; Anesthesia, Intravenous; Anest | 2003 |
Age-related effects in the EEG during propofol anaesthesia.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthet | 2004 |
Onset and offset pharmacodynamics of propofol.
Topics: Adipose Tissue; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Intravenous; Body Co | 2004 |
Propofol sedation for longitudinal pediatric neuroimaging research.
Topics: Aging; Anesthetics, Intravenous; Blood Pressure; Child; Child, Preschool; Conscious Sedation; Female | 2005 |
Influence of aging on lidocaine requirements for pain on injection of propofol.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Anesthetics, Intravenou | 2006 |
Age-related differences in metoclopramide requirement for pain on injection of propofol.
Topics: Adult; Aged; Aging; Double-Blind Method; Female; Humans; Injections; Male; Metoclopramide; Middle Ag | 2006 |
Plasma concentrations of brain-derived neurotrophic factor in patients undergoing minor surgery: a randomized controlled trial.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Inhalation; Anestheti | 2008 |
[Age-related correlation between EEG parameters and depth of anesthesia under propofol. Effect of fentanyl].
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aging; Anesthetics, Combined; Anesthetics, Intravenous; El | 1996 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr | 1998 |
Comparison of the intubation conditions provided by rapacuronium (ORG 9487) or succinylcholine in humans during anesthesia with fentanyl and propofol.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Combined; Anesthetics, Intravenous; | 1999 |
Population pharmacokinetics of propofol: a multicenter study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Algorithms; Anesthetics, Intravenous; Body Weight | 2000 |
The combined effect of age and premedication on the propofol requirements for induction by target-controlled infusion.
Topics: Adjuvants, Anesthesia; Adult; Aged; Aging; Analgesics, Opioid; Anesthetics, Intravenous; Blood Press | 2000 |
Effect of midazolam pretreatment on induction dose requirements of propofol in combination with fentanyl in younger and older adults.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aging; Analysis of Variance; Anesthetics, Intravenou | 2001 |
Postoperative reading speed does not indicate implicit memory in elderly cardiac patients after propofol and remifentanyl anaesthesia.
Topics: Acoustic Stimulation; Adult; Aged; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Awarene | 2001 |
66 other studies available for propofol and Aging
| Article | Year |
|---|---|
Avenanthramide-C Activates Nrf2/ARE Pathway and Inhibiting Ferroptosis Pathway to Improve Cognitive Dysfunction in Aging Rats.
Topics: Aging; Animals; Cognitive Dysfunction; Ferroptosis; Hippocampus; Neuroinflammatory Diseases; NF-E2-R | 2023 |
Age progression from vicenarians (20-29 year) to nonagenarians (90-99 year) among a population pharmacokinetic/pharmacodynamic (PopPk-PD) covariate analysis of propofol-bispectral index (BIS) electroencephalography.
Topics: Adult; Aged; Aged, 80 and over; Aging; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous | 2020 |
A longitudinal, multi-parametric functional MRI study to determine age-related changes in the rodent brain.
Topics: Aging; Anesthetics, Intravenous; Animals; Brain; Female; Longitudinal Studies; Magnetic Resonance Im | 2020 |
Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a "Vulnerable Brain".
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alpha Rhythm; Anesthesia; Anesthetics, Intravenou | 2020 |
Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and NLRP3 inflammasome.
Topics: Aging; Anesthetics, Intravenous; Animals; Cognition; Cognition Disorders; Conditioning, Operant; Hip | 2021 |
Impact of aging on interactions between opioid and propofol concentrations during total intravenous anesthesia.
Topics: Aging; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; Humans; Propofol | 2021 |
Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice.
Topics: Administration, Intranasal; Aging; Anesthesia; Anesthetics, Intravenous; Animals; Brain; Cognitive D | 2019 |
Control of depth of anaesthesia using fractional-order adaptive high-gain controller.
Topics: Aging; Anesthesia; Body Height; Female; Humans; Male; Models, Biological; Propofol; Sex Characterist | 2019 |
Propofol increases vascular relaxation in aging rats chronically treated with the angiotensin-converting enzyme inhibitor captopril.
Topics: Aging; Anesthetics, Intravenous; Angiotensin-Converting Enzyme Inhibitors; Animals; Area Under Curve | 2013 |
General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt.
Topics: Aging; Anesthetics, Intravenous; Animals; Animals, Newborn; Female; Gene Expression Regulation, Deve | 2013 |
Effects of isoflurane or propofol on postnatal hippocampal neurogenesis in young and aged rats.
Topics: Aging; Anesthesia, General; Anesthetics, Inhalation; Animals; Cell Differentiation; Cell Proliferati | 2013 |
Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice.
Topics: Aging; Alzheimer Disease; Amyloidogenic Proteins; Animals; Brain; Caspases; Cell Line, Tumor; Cognit | 2014 |
A general purpose pharmacokinetic model for propofol.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Algorithms; Anesthesia, Intravenous; | 2014 |
Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice.
Topics: Aging; Anesthetics, General; Animals; Mice; Phosphorylation; Prefrontal Cortex; Propofol; Receptors, | 2014 |
Propofol-induced relaxation of rat aorta is altered by aging.
Topics: Aging; Anesthetics, Intravenous; Animals; Aorta, Thoracic; Male; NG-Nitroarginine Methyl Ester; Nitr | 2014 |
Propofol-induced age-different hypocampal long-term potentiation is associated with F-actin polymerization in rats.
Topics: Actins; Aging; Anesthetics, Intravenous; Animals; CA1 Region, Hippocampal; Cognition; Long-Term Pote | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal | 2015 |
Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain.
Topics: Aging; Anesthesia, General; Anesthetics; Animals; Brain; Electroencephalography; Isoflurane; Male; M | 2015 |
Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice.
Topics: Adult; Aged; Aged, 80 and over; Aging; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous | 2016 |
The ageing brain.
Topics: Aging; Anesthesia, General; Brain; Electroencephalography; Propofol; Sevoflurane | 2016 |
Spatial memory is intact in aged rats after propofol anesthesia.
Topics: Aging; Anesthesia, General; Anesthetics, Intravenous; Animals; Maze Learning; Memory; Propofol; Rats | 2008 |
GABAergic mechanism of propofol toxicity in immature neurons.
Topics: Aging; Anesthetics, Intravenous; Animals; Calcium; Calcium Channel Agonists; Calcium Channels, L-Typ | 2008 |
Urinary propofol metabolites in early life after single intravenous bolus.
Topics: Aging; Anesthetics, Intravenous; Body Weight; Humans; Hydroquinones; Infant; Infant, Newborn; Metabo | 2008 |
The effects of propofol on vascular function in mesenteric arteries of the aging rat.
Topics: Acetylcholine; Aging; Animals; Antioxidants; Biological Factors; Dose-Response Relationship, Drug; E | 2009 |
Bispectral and spectral entropy indices at propofol-induced loss of consciousness in young and elderly patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Intravenous; Consciousness; Drug Administration | 2009 |
Bedside prediction of airway length in adults and children.
Topics: Adolescent; Adult; Aged; Aging; Algorithms; Androstanols; Anesthesia, General; Anesthetics, Intraven | 2009 |
The effect of a target controlled infusion of propofol on predictability of recovery from anesthesia in children.
Topics: Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intrav | 2010 |
[Comparative study of induction time using propofol bolus injection in elderly patients].
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, | 2010 |
Clinically relevant asymmetry of bispectral index during recovery from anaesthesia for ear-nose-throat surgery in adults and children.
Topics: Adult; Aging; Anesthesia; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; | 2011 |
A bodyweight-dependent allometric exponent for scaling clearance across the human life-span.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anesthetics, Intravenous; Body Weigh | 2012 |
Quantitative assessment of new cell proliferation in the dentate gyrus and learning after isoflurane or propofol anesthesia in young and aged rats.
Topics: Aging; Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Cell Proliferation; Dentate Gyrus; | 2012 |
Changes of learning and memory in aged rats after isoflurane inhalational anaesthesia correlated with hippocampal acetylcholine level.
Topics: Acetylcholine; Aging; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Brain Chemi | 2012 |
[Recovery from total intravenous anesthesia with propofol and buprenorphine].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia Recovery Period; Anesthesia, Intraveno | 2002 |
Target-controlled infusion of propofol and remifentanil in cardiac anaesthesia: influence of age on predicted effect-site concentrations.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anesthetics, Combined; Anesthetics, | 2003 |
Propofol enhances ischemic tolerance of middle-aged rat hearts: effects on 15-F(2t)-isoprostane formation and tissue antioxidant capacity.
Topics: Aging; Animals; Antioxidants; Disease Susceptibility; Male; Myocardial Ischemia; Myocardial Reperfus | 2003 |
Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics.
Topics: Aging; Algorithms; Anesthetics, Intravenous; Computer Simulation; Data Interpretation, Statistical; | 2003 |
Autonomic mechanisms in the age-related hypotensive effect of propofol.
Topics: Aging; Anesthetics, Intravenous; Animals; Autonomic Nervous System; Baroreflex; Blood Pressure; Dose | 2005 |
Impact of patient age on propofol consumption during propofol-remifentanil anaesthesia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia Recovery Period; Anesthesia, Intraveno | 2005 |
Allometric relationships between the pharmacokinetics of propofol in rats, children and adults.
Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Animals; Body Weight; Child, Preschool; Drug Evaluatio | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Pharmacokinetics of a single bolus of propofol in chinese children of different ages.
Topics: Aging; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Weight; Child; Child, Pre | 2006 |
The kinetics of Ringer's solution in young and elderly patients during induction of general anesthesia with propofol and epidural anesthesia with ropivacaine.
Topics: Adult; Aged; Aging; Algorithms; Amides; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Intr | 2007 |
Inter-individual variability in propofol pharmacokinetics in preterm and term neonates.
Topics: Aging; Anesthetics, Intravenous; Body Weight; Creatinine; Drug Administration Schedule; Female; Gest | 2007 |
EEG variables as measures of arousal during propofol anaesthesia for general surgery in children: rational selection and age dependence.
Topics: Adolescent; Aging; Anesthesia, General; Anesthetics, Combined; Anesthetics, Intravenous; Arousal; Bl | 2007 |
Variation of bispectral index under TIVA with propofol in a paediatric population.
Topics: Adolescent; Aging; Anesthetics, Intravenous; Blood Pressure; Child; Child, Preschool; Dose-Response | 2008 |
Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children.
Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Intravenous; Blood P | 2008 |
Volumetric capnography in children. Influence of growth on the alveolar plateau slope.
Topics: Adolescent; Aging; Anesthesia; Body Constitution; Carbon Dioxide; Child; Child, Preschool; Halothane | 1995 |
[Use of Diprivan in the elderly].
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Hemodynamics; Humans; Propofol | 1994 |
[Total intravenous anesthesia (TIVA) with propofol in the elderly patient].
Topics: Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Central Nervous System; Female; Humans; Mal | 1993 |
The effects of verapamil and lidocaine on the duration of propofol and xylazine-ketamine anesthesia in broiler chickens.
Topics: Aging; Analysis of Variance; Anesthesia; Anesthetics; Animals; Calcium Channel Blockers; Chickens; D | 1996 |
Age-dependent development of acute tolerance to propofol and its distribution in a pharmacokinetic compartment-independent rat model.
Topics: Aging; Anesthetics, Intravenous; Animals; Chromatography, High Pressure Liquid; Drug Tolerance; Elec | 1996 |
Pharmacokinetics of propofol as an induction agent in geriatric dogs.
Topics: Aging; Animals; Dogs; Injections, Intravenous; Metabolic Clearance Rate; Propofol; Species Specifici | 1996 |
Age-related propofol effects on electrophysiological properties of isolated hearts.
Topics: Aging; Anesthetics, Intravenous; Animals; Animals, Newborn; Atrial Function; Atrioventricular Node; | 1997 |
The influence of age and administration rate on the brain sensitivity to propofol in rats.
Topics: Aging; Anesthesia; Anesthetics, Intravenous; Animals; Body Weight; Brain; Dose-Response Relationship | 1998 |
Aging decreases the sensitivity of the GABA carrier to propofol and etomidate.
Topics: Aging; Anesthetics, Intravenous; Animals; Cell Culture Techniques; Etomidate; gamma-Aminobutyric Aci | 1998 |
Aging prolongs recovery of psychomotor functions at emergence from propofol-alfentanil anaesthesia.
Topics: Adult; Aged; Aging; Alfentanil; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, In | 1998 |
GABA(A) receptor in growth cones: the outline of GABA(A) receptor-dependent signaling in growth cones is applicable to a variety of alpha-subunit species.
Topics: Aging; Animals; Animals, Newborn; Calcium; Cerebral Cortex; Chlorides; Diazepam; Fetus; gamma-Aminob | 1999 |
[The influence of age on hemodynamics and the dose requirements of propofol and buprenorphine in total intravenous anesthesia].
Topics: Adult; Aged; Aging; Anesthesia Recovery Period; Anesthesia, Intravenous; Body Weight; Buprenorphine; | 2001 |
[The influence of age on hemodynamics and the dose requirements of propofol and buprenorphine in total intravenous anesthesia combined with continuous epidural anesthesia].
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia, | 2001 |
Gender differences in the pharmacokinetics of propofol in elderly patients during and after continuous infusion.
Topics: Aged; Aged, 80 and over; Aging; Anesthetics, Intravenous; Body Weight; Computer Simulation; Female; | 2001 |
Plasma proinflammatory cytokine response to surgical stress in elderly patients.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anesthetics, Inhalation; Anesthetics, Intravenou | 2001 |
Direct effects of propofol on myocardial and vascular tissue from mature and immature rats.
Topics: Aging; Anesthetics, Intravenous; Animals; Aorta, Thoracic; Depression, Chemical; Dose-Response Relat | 2001 |
[Propofol anesthesia for ophthalmologic surgery in the elderly].
Topics: Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Cataract Extraction; Humans; Propofol; Reti | 1992 |
The induction dose of propofol in infants 1-6 months of age and in children 10-16 years of age.
Topics: Adolescent; Aging; Anesthesia, Intravenous; Blood Pressure; Child; Dose-Response Relationship, Drug; | 1991 |
Lean tissue mass is a useful predictor of induction dose requirements for propofol.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Body Composition; Female | 1991 |
Pharmacokinetics of propofol (diprivan) in elderly patients.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Humans; Phenols; Propofol | 1988 |