Page last updated: 2024-11-03

propofol and Aging

propofol has been researched along with Aging in 92 studies

Propofol: An intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (From Smith and Reynard, Textbook of Pharmacology, 1992, 1st ed, p206). Propofol has been used as ANTICONVULSANTS and ANTIEMETICS.
propofol : A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"This pilot study established a system to compare effects of different anesthetics and generated a hypothesis that propofol trended to have a higher incidence and had longer duration of postoperative delirium than sevoflurane."9.34The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study. ( Li, C; Ma, X; Marcantonio, E; Mei, X; Shen, Y; Xie, Z; Zheng, H; Zheng, HL, 2020)
"To determine the combined effects of aging and propofol on autonomic nervous system activity using heart rate variability (HRV) analysis."9.17Effects of aging and propofol on the cardiovascular component of the autonomic nervous system. ( El Beheiry, H; Mak, P, 2013)
"This study showed that older patients require less metoclopramide, with venous occlusion for 1 minute, to reduce pain on injection of propofol than do younger patients."9.12Age-related differences in metoclopramide requirement for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006)
"Pain during injection of propofol was evaluated."9.12Influence of aging on lidocaine requirements for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006)
"There is disagreement about allowing propofol sedation for research magnetic resonance imaging/spectroscopy (MRI/MRS) in children."9.11Propofol sedation for longitudinal pediatric neuroimaging research. ( Amundsen, LB; Artru, AA; Dager, SR; Dawson, G; Friedman, S; Shaw, DW; Sparks, B, 2005)
"Clonidine premedication augments the pressor and tachycardiac responses to ephedrine in elderly patients during standard or large doses of propofol anesthesia but does not augment during small doses of propofol anesthesia."9.10The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia. ( Ishiyama, T; Kashimoto, S; Kumazawa, T; Matsukawa, T; Oguchi, T, 2003)
"Propofol pretreatment increased MCh relaxation in arteries from captopril-treated compared with untreated rats (P = 0."5.39Propofol increases vascular relaxation in aging rats chronically treated with the angiotensin-converting enzyme inhibitor captopril. ( Bourque, SL; Davidge, ST; Gragasin, FS, 2013)
" We hypothesized that propofol increases nitric oxide (NO)-mediated vasodilation by enhancing its bioavailability in the aged adult vasculature, leading to greater vasodilation than in the young adult."5.35The effects of propofol on vascular function in mesenteric arteries of the aging rat. ( Davidge, ST; Gragasin, FS, 2009)
"This pilot study established a system to compare effects of different anesthetics and generated a hypothesis that propofol trended to have a higher incidence and had longer duration of postoperative delirium than sevoflurane."5.34The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study. ( Li, C; Ma, X; Marcantonio, E; Mei, X; Shen, Y; Xie, Z; Zheng, H; Zheng, HL, 2020)
"This study showed that older patients require less metoclopramide, with venous occlusion for 1 minute, to reduce pain on injection of propofol than do younger patients."5.12Age-related differences in metoclopramide requirement for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006)
"Pain during injection of propofol was evaluated."5.12Influence of aging on lidocaine requirements for pain on injection of propofol. ( Fujii, Y; Shiga, Y, 2006)
"There is disagreement about allowing propofol sedation for research magnetic resonance imaging/spectroscopy (MRI/MRS) in children."5.11Propofol sedation for longitudinal pediatric neuroimaging research. ( Amundsen, LB; Artru, AA; Dager, SR; Dawson, G; Friedman, S; Shaw, DW; Sparks, B, 2005)
"Infants and children undergoing magnetic resonance imaging with propofol sedation had determinations of the transverse and anterior-posterior (AP) dimensions of the larynx at the most cephalad level of the larynx (vocal cords) and the most caudad level (cricoid)."5.10Developmental changes of laryngeal dimensions in unparalyzed, sedated children. ( Litman, RS; Shibata, D; Weissend, EE; Westesson, PL, 2003)
"Clonidine premedication augments the pressor and tachycardiac responses to ephedrine in elderly patients during standard or large doses of propofol anesthesia but does not augment during small doses of propofol anesthesia."5.10The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia. ( Ishiyama, T; Kashimoto, S; Kumazawa, T; Matsukawa, T; Oguchi, T, 2003)
" The aging rat model was established by continuous 200 mg/kg propofol anesthesia."4.31Avenanthramide-C Activates Nrf2/ARE Pathway and Inhibiting Ferroptosis Pathway to Improve Cognitive Dysfunction in Aging Rats. ( Cao, X; Ma, Y; Ma, Z; Song, T; Zhang, Y, 2023)
"The relationship between the pharmacokinetic parameters of propofol obtained in rats, children and adults was analyzed by plotting the logarithmically transformed parameters against the corresponding logarithmically transformed body weights."3.73Allometric relationships between the pharmacokinetics of propofol in rats, children and adults. ( Aarts, LP; Danhof, M; Knibbe, CA; Kuks, PF; Zuideveld, KP, 2005)
"Fifty patients more than 70 years old, ASA I and II, NYHA I and II, were anaesthetized by propofol for cataract or retinal detachment surgery."3.68[Propofol anesthesia for ophthalmologic surgery in the elderly]. ( Dandoy, M; Lampl, E; Maurin, JP; Poisson, F; Reynaud, S, 1992)
"Propofol was continuously infused during surgery and spinal anesthesia in 15 elderly patients (65-85 yr-old) and 15 younger patients (20-50 yr-old)."2.70Recovery of psychomotor function after propofol sedation is prolonged in the elderly. ( Kitajima, T; Okuda, Y; Shinozaki, M; Usui, Y; Yamaguchi, S, 2002)
"Midazolam pretreatment was associated with a significant reduction in propofol dose requirement in both younger and older patients."2.70Effect of midazolam pretreatment on induction dose requirements of propofol in combination with fentanyl in younger and older adults. ( Bhaskaran, NC; Claydon, P; Cressey, DM; Reilly, CS, 2001)
"Rapacuronium is an investigational nondepolarizing relaxant that also has a rapid onset and short duration and consequently should be compared with succinylcholine in its ability to facilitate rapid tracheal intubation."2.69Comparison of the intubation conditions provided by rapacuronium (ORG 9487) or succinylcholine in humans during anesthesia with fentanyl and propofol. ( Caldwell, JE; Chan, V; Chung, F; Cicutti, N; Fleming, NW; Gan, TJ; Glass, PS; Gronert, GA; Kirkegaard-Nielsen, H; Kitts, JB, 1999)
" Population pharmacokinetic modeling was performed using NONMEM (NONMEM Project Group, University of California, San Francisco, CA)."2.69Population pharmacokinetics of propofol: a multicenter study. ( Ihmsen, H; Schüttler, J, 2000)
"The propofol requirements were significantly less in the midazolam-fentanyl groups, regardless of age, and among the premedicated patients older than 60 yr compared with the other age groups."2.69The combined effect of age and premedication on the propofol requirements for induction by target-controlled infusion. ( Ballester, JA; Elizalde, JL; Escobar, A; Olmos, M; Vidarte, MA, 2000)
" The dosage was calculated from the infusion time (time from start of infusion until specific clinical event)."2.68[Age-related correlation between EEG parameters and depth of anesthesia under propofol. Effect of fentanyl]. ( Eckert, O; Lehmkuhl, P; Neulinger, A; Pichlmayr, I; Werry, C, 1996)
" On the basis of pharmacokinetic-pharmacodynamic modelling, a mean blood-brain equilibration half-life of only 2."2.38Pharmacokinetic implications for the clinical use of propofol. ( Gepts, E; Kanto, J, 1989)
" We proposed 5 different models consisting of different combinations of potential contributing factors associated with burst suppression: (1) a Base Model consisting of alpha power; (2) an Extended Mechanistic Model consisting of alpha power, age, and drug dosing information; (3) a Clinical Confounding Factors Model consisting of alpha power, hypotension, and other confounds; (4) a Simplified Model consisting only of alpha power and propofol bolus administration; and (5) a Full Model consisting of all of these variables to control for as much confounding as possible."1.56Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a "Vulnerable Brain". ( Brown, EN; Colvin, C; Deng, H; Dickerson, BC; Houle, TT; Kahali, P; Purdon, PL; Shao, YR, 2020)
"Propofol was added intraperitoneally to the mice from 7th day of insulin/saline treatment, and general anesthesia was induced and maintained for 2 hours/day for 5 consecutive days."1.51Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice. ( Huang, F; Ke, D; Li, X; Liang, Z; Liu, R; Run, X; Wang, JZ; Wang, Q; Wang, X; Wei, Z; Zeng, K; Zhang, B, 2019)
"No significant decrease in dosing between age groups was observed for fentanyl and midazolam."1.43Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice. ( Akhtar, S; Burg, MM; Dai, F; Heng, J; Liu, J; Schonberger, RB, 2016)
"When methylphenidate was administered after propofol, the mean time to emergence decreased to 6."1.42Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain. ( Brown, EN; Chemali, JJ; Kenny, JD; Kimchi, EY; Olutola, O; Purdon, PL; Solt, K; Taylor, NE, 2015)
"Propofol was administrated to the WT and AD Tg mice once a week for 8 or 12 weeks, respectively."1.40Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice. ( Dong, Y; Shao, H; Xia, W; Xie, Z; Yu, B; Zhang, Y, 2014)
"Propofol caused an increase in GluA1 phosphorylation in the hippocampus but not in the prefrontal cortex."1.40Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice. ( Fibuch, EE; Hastings, JM; Mao, LM; Wang, JQ, 2014)
"Propofol pretreatment increased MCh relaxation in arteries from captopril-treated compared with untreated rats (P = 0."1.39Propofol increases vascular relaxation in aging rats chronically treated with the angiotensin-converting enzyme inhibitor captopril. ( Bourque, SL; Davidge, ST; Gragasin, FS, 2013)
"The isoflurane anaesthesia treatment increased the escape latency contrast to propofol anaesthesia group."1.38Changes of learning and memory in aged rats after isoflurane inhalational anaesthesia correlated with hippocampal acetylcholine level. ( Feng, C; Jia, X; Wang, H; Wang, Y; Wu, A; Xu, Z; Yue, Y, 2012)
" We hypothesized that propofol increases nitric oxide (NO)-mediated vasodilation by enhancing its bioavailability in the aged adult vasculature, leading to greater vasodilation than in the young adult."1.35The effects of propofol on vascular function in mesenteric arteries of the aging rat. ( Davidge, ST; Gragasin, FS, 2009)
"/st> Propofol clearance is lower in neonates than in adults and displays extensive interindividual variability, in part explained by postmenstrual age (PMA) and postnatal age (PNA)."1.35Urinary propofol metabolites in early life after single intravenous bolus. ( Allegaert, K; Cossey, V; de Hoon, J; Naulaers, G; Rayyan, M; Vancraeynest, J; Verbesselt, R, 2008)
"As propofol is a GABAA agonist, we hypothesized that it and more specific GABAA modulators would increase intracellular free calcium ([Ca2+]i), resulting in the death of neonatal rat hippocampal neurons."1.35GABAergic mechanism of propofol toxicity in immature neurons. ( Fiskum, G; Kahraman, S; McCarthy, MM; Zup, SL, 2008)
"Propofol has different receptor mechanisms of action and a favorable short-term recovery profile, and it has been proposed that propofol is devoid of enduring effects on cognitive performance."1.35Spatial memory is intact in aged rats after propofol anesthesia. ( Baxter, MG; Crosby, G; Culley, DJ; Lee, IH; Tanzi, RE; Xie, Z, 2008)
" The pharmacodynamic parameters were estimated by non-linear regression analysis."1.35Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children. ( Ammon, C; Fechner, J; Ihmsen, H; Jeleazcov, C; Schmidt, J; Schüttler, J; Schwilden, H, 2008)
" Statistically significant multivariate predictors of hypotension 0-10 min after anesthetic induction included: ASA III-V, baseline MAP <70 mm Hg, age > or =50 yr, the use of propofol for induction of anesthesia, and increasing induction dosage of fentanyl."1.33Predictors of hypotension after induction of general anesthesia. ( Baez, B; Bernstein, A; Bodian, CA; Hossain, S; Krol, M; Patel, P; Reich, DL, 2005)
"This study supports the case that the pharmacokinetic properties of propofol do not differ substantially across Chinese children of different ages after weight has been accounted for."1.33Pharmacokinetics of a single bolus of propofol in chinese children of different ages. ( Aarons, L; Chen, X; Freemantle, N; Lian, Q; Matthews, I; Shangguan, WN; Smith, FG; Wang, Z, 2006)
"Propofol was then given as an IV bolus of 4."1.33Autonomic mechanisms in the age-related hypotensive effect of propofol. ( Heerdt, PM; Memtsoudis, SG; The, AHS, 2005)
"Propofol in KH was perfused at 12 microg/ml for the first 15 min of reperfusion and subsequently reduced to 5 microg/ml in propofol treatment groups."1.32Propofol enhances ischemic tolerance of middle-aged rat hearts: effects on 15-F(2t)-isoprostane formation and tissue antioxidant capacity. ( Ansley, DM; Godin, DV; Xia, Z, 2003)
"To simulate the time course of drug effect, it is sometimes necessary to combine the pharmacodynamic parameters from an integrated pharmacodynamic-pharmacodynamic study (e."1.32Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics. ( Gregg, KM; Henthorn, TK; Minto, CF; Schnider, TW; Shafer, SL, 2003)
" To increase our insight into the pharmacokinetics of propofol in this patient population and to obtain pharmacokinetic parameters applicable in target controlled infusion (TCI), the pharmacokinetics of propofol during and after continuous infusion were studied in 31 ASA class 1 and 2 patients, aged 65-91 yr, scheduled for general surgery."1.31Gender differences in the pharmacokinetics of propofol in elderly patients during and after continuous infusion. ( Bovill, JG; Burm, AG; Oostwouder, CJ; Vletter, AA; Vuyk, J, 2001)
"Propofol was more potent in the younger animals (EC(50), 5."1.31Direct effects of propofol on myocardial and vascular tissue from mature and immature rats. ( Lundell, JC; Neville, MJ; Ririe, DG, 2001)
"A retrospective study was performed to determine the influence of age on hemodynamics and awakening time in total intravenous anesthesia (TIVA) using propofol and buprenorphine combined with continuous epidural anesthesia for abdominal surgery."1.31[The influence of age on hemodynamics and the dose requirements of propofol and buprenorphine in total intravenous anesthesia combined with continuous epidural anesthesia]. ( Tabuchi, Y, 2001)
" These data contrast with other studies in which dosage was based on total body mass where a decrease in dose requirement with age was demonstrated."1.28Lean tissue mass is a useful predictor of induction dose requirements for propofol. ( Crankshaw, DP; Leslie, K, 1991)

Research

Studies (92)

TimeframeStudies, this research(%)All Research%
pre-19902 (2.17)18.7374
1990's17 (18.48)18.2507
2000's40 (43.48)29.6817
2010's25 (27.17)24.3611
2020's8 (8.70)2.80

Authors

AuthorsStudies
Ma, Z1
Ma, Y1
Cao, X1
Zhang, Y2
Song, T1
Dahaba, AA1
Xiao, Z1
Zhu, X1
Dong, H1
Xiong, L1
Rehak, P1
Zelzer, S1
Wang, K1
Reibnegger, G1
Crofts, A1
Trotman-Lucas, M1
Janus, J1
Kelly, M1
Gibson, CL1
Mei, X1
Zheng, HL1
Li, C1
Ma, X1
Zheng, H1
Marcantonio, E1
Xie, Z3
Shen, Y2
Shao, YR1
Kahali, P1
Houle, TT1
Deng, H1
Colvin, C1
Dickerson, BC1
Brown, EN3
Purdon, PL3
Liu, PF1
Gao, T1
Li, TZ1
Yang, YT1
Xu, YX1
Xu, ZP1
Mi, WD1
Linassi, F1
Kreuzer, M1
Maran, E1
Farnia, A1
Zanatta, P1
Navalesi, P1
Carron, M1
Matsuki, Y1
Nagata, O1
Ogino, Y1
Shigemi, K1
Li, X1
Run, X1
Wei, Z1
Zeng, K1
Liang, Z1
Huang, F1
Ke, D1
Wang, Q1
Wang, JZ1
Liu, R1
Zhang, B1
Wang, X1
Boroujerdi Alavi, M1
Tabatabaei, M1
Gragasin, FS2
Bourque, SL1
Davidge, ST2
Lacoh, CM1
Bodogan, T1
Kaila, K1
Fiumelli, H1
Vutskits, L2
Erasso, DM2
Camporesi, EM2
Mangar, D1
Saporta, S2
El Beheiry, H1
Mak, P1
Shao, H1
Dong, Y1
Yu, B1
Xia, W1
Eleveld, DJ1
Proost, JH1
Cortínez, LI1
Absalom, AR1
Struys, MM1
Mao, LM1
Hastings, JM1
Fibuch, EE1
Wang, JQ1
Sakai, Y1
Kawahito, S1
Takaishi, K1
Mita, N1
Kinoshita, H1
Hatakeyama, N1
Azma, T1
Nakaya, Y1
Kitahata, H1
Li, M1
Zhang, X1
Wu, A2
Wang, Z2
Li, J1
Yue, Y2
Pavone, KJ1
Akeju, O1
Smith, AC1
Sampson, AL1
Lee, J1
Zhou, DW1
Solt, K2
Chemali, JJ1
Kenny, JD1
Olutola, O1
Taylor, NE1
Kimchi, EY1
Akhtar, S1
Liu, J1
Heng, J1
Dai, F1
Schonberger, RB1
Burg, MM1
Osthaus, WA1
Lee, IH1
Culley, DJ1
Baxter, MG1
Tanzi, RE1
Crosby, G1
Kahraman, S1
Zup, SL1
McCarthy, MM1
Fiskum, G1
Allegaert, K3
Vancraeynest, J1
Rayyan, M1
de Hoon, J1
Cossey, V1
Naulaers, G2
Verbesselt, R2
Lysakowski, C2
Elia, N1
Czarnetzki, C2
Dumont, L1
Haller, G1
Combescure, C1
Tramèr, MR2
Lee, BJ1
Yi, JW1
Chung, JY1
Kim, DO1
Kang, JM1
McCormack, J1
Mehta, D1
Peiris, K1
Dumont, G1
Fung, P1
Lim, J1
Ansermino, JM1
Büttner, N1
Schultz, B2
Grouven, U2
Schultz, A2
Miki, S1
Matsumoto, K1
Fudickar, A1
Voss, D1
Serocki, G1
Jeckström, W1
Ambrosch, P1
Steinfath, M1
Bein, B1
Jeong, CW1
Ju, J1
Lee, DW1
Lee, SH1
Yoon, MH1
Aimé, I1
Gayat, E1
Fermanian, C1
Cook, F1
Peuch, C1
Laloë, PA1
Mantz, J3
Fischler, M1
Wang, C1
Peeters, MY2
Blussé van Oud-Alblas, HJ1
Krekels, EH1
Tibboel, D2
Danhof, M2
Knibbe, CA3
Chaparro, RE1
Quiroga Del Rio, CE1
Karlnoski, R1
Wang, H1
Xu, Z1
Feng, C1
Wang, Y1
Jia, X1
Constant, I1
Sabourdin, N1
Soltész, S1
Silomon, M1
Mencke, T1
Schlaich, N1
Fuchs-Buder, T1
Tabuchi, Y3
Shinozaki, M1
Usui, Y1
Yamaguchi, S1
Okuda, Y1
Kitajima, T1
Litman, RS1
Weissend, EE1
Shibata, D1
Westesson, PL1
Ishiyama, T1
Kashimoto, S1
Oguchi, T1
Matsukawa, T1
Kumazawa, T1
Ouattara, A1
Boccara, G1
Lemaire, S1
Köckler, U1
Landi, M1
Vaissier, E1
Léger, P1
Coriat, P1
Xia, Z1
Godin, DV1
Ansley, DM1
Minto, CF2
Schnider, TW2
Gregg, KM1
Henthorn, TK1
Shafer, SL2
Eilers, H1
Niemann, C1
Zander, I1
Beger, FA1
Siedenberg, M1
O'Halloran, PL1
Hosseini-Yeganeh, M1
McBride, LJ1
Ramzan, I1
Memtsoudis, SG1
The, AHS1
Heerdt, PM1
Kreuer, S1
Schreiber, JU1
Bruhn, J1
Wilhelm, W1
Zuideveld, KP1
Aarts, LP1
Kuks, PF1
Reich, DL1
Hossain, S1
Krol, M1
Baez, B1
Patel, P1
Bernstein, A1
Bodian, CA1
Amundsen, LB1
Artru, AA1
Dager, SR1
Shaw, DW1
Friedman, S1
Sparks, B1
Dawson, G1
Shangguan, WN1
Lian, Q1
Aarons, L1
Matthews, I1
Chen, X1
Freemantle, N1
Smith, FG1
Fujii, Y2
Shiga, Y2
Li, Y1
Zhu, S1
Hahn, RG1
de Hoon, JN1
Jeleazcov, C2
Schmidt, J2
Schmitz, B1
Becke, K1
Albrecht, S1
Tirel, O1
Wodey, E1
Harris, R1
Bansard, JY1
Ecoffey, C1
Senhadji, L1
Ihmsen, H2
Ammon, C1
Schwilden, H1
Schüttler, J2
Fechner, J1
Jenny, B1
Copin, JC1
Ream, RS1
Schreiner, MS1
Neff, JD1
McRae, KM1
Jawad, AF1
Scherer, PW1
Neufeld, GR1
Stieglitz, P1
Scafuro, M1
Cafaggi, G1
Di Gregorio, AM1
Petrella, F1
Roder, JD1
Sangiah, S1
Larsson, JE2
Wahlström, G2
Reid, J1
Nolan, AM1
Werry, C1
Neulinger, A1
Eckert, O1
Lehmkuhl, P1
Pichlmayr, I1
Wu, MH1
Su, MJ1
Sun, SS1
Gambus, PL1
Andresen, C1
Goodale, DB1
Youngs, EJ1
Keita, H2
Lasocki, S1
Henzel-Rouellé, D1
Desmonts, JM2
Peytavin, G1
Giraud, O1
Silleran, J1
Rahoeliarivaraux, L1
Fukura, H1
Kitani, Y1
Komiya, Y1
Igarashi, M1
Fleming, NW1
Chung, F1
Glass, PS1
Kitts, JB1
Kirkegaard-Nielsen, H1
Gronert, GA1
Chan, V1
Gan, TJ1
Cicutti, N1
Caldwell, JE1
Olmos, M1
Ballester, JA1
Vidarte, MA1
Elizalde, JL1
Escobar, A1
Cressey, DM1
Claydon, P1
Bhaskaran, NC1
Reilly, CS1
Münte, S1
Münte, TF1
Mitzlaff, B1
Walz, R1
Leuwer, M1
Piepenbrock, S1
Vuyk, J1
Oostwouder, CJ1
Vletter, AA1
Burm, AG1
Bovill, JG1
Kudoh, A1
Katagai, H1
Takazawa, T1
Matsuki, A1
Ririe, DG1
Lundell, JC1
Neville, MJ1
Dandoy, M1
Reynaud, S1
Poisson, F1
Lampl, E1
Maurin, JP1
Westrin, P1
Leslie, K1
Crankshaw, DP1
Kanto, J1
Gepts, E1
Kirkpatrick, T1
Cockshott, ID1
Douglas, EJ1
Nimmo, WS1

Clinical Trials (29)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Age on Propofol-Bispectral Index Response Relationship Among Different Age Groups From Vicenarians to Nonagenarians. A New Logistic Model Compared With Traditional Sigmoid Emax Model[NCT02585284]80 participants (Actual)Observational2011-09-30Completed
Development of a Pharmacodynamic Model for Propofol in Older Adults (Development phaRmacodynamic mOdel Propofol oLdEr adulTs: DROPLET)[NCT05790720]60 participants (Anticipated)Interventional2023-12-01Not yet recruiting
Intranasal Insulin Improves Postoperative Neurocognitive Disorders in Elderly Patients: a Multicenter, Randomized, Double-blind, Placebo-controlled Study[NCT05613491]438 participants (Anticipated)Interventional2022-11-07Recruiting
Study of an Intraoperative Frontal Electroencephalographic Marker of Preoperative Frailty in Patients Over 65 Years of Age for Elective Non-cardiac Surgery.[NCT04783662]60 participants (Actual)Observational2021-05-13Completed
Cognitive Outcomes and Neuroimages Associated With Anesthesia-Related EEG Signatures[NCT03442179]24 participants (Actual)Observational2019-02-13Active, not recruiting
The Role of Brain Wave Monitoring in Reducing the Incidence of Postoperative Cognitive Dysfunction[NCT04189861]100 participants (Anticipated)Observational2020-01-24Recruiting
Relationship Between Bispectral Index, EEG Features, and Propofol Effect-site Concentration in Young and Elderly Patients.[NCT04774120]30 participants (Actual)Observational2020-12-11Completed
Core Temperature Variations During Midazolam vs Propofol Sedation for Neuraxial Anesthesia[NCT02502877]27 participants (Actual)Interventional2015-07-31Completed
Comparison of the Bispectral Index and the Entropy of the Electroencephalogram During Total Intravenous Anesthesia[NCT00391963]84 participants Observational2006-06-30Completed
EEG-based Depth of Anesthesia-monitoring During General Anesthesia - Effects on Time to Wake-up and Post-operative Cognition[NCT04529304]100 participants (Anticipated)Interventional2021-01-08Recruiting
Shape and Dimensions of the Upper Airway in Infants Using Computed Tomography Imaging[NCT02925169]40 participants (Actual)Observational2016-04-30Completed
Volumetric Three-dimensional Analysis of the Pediatric Upper Airway Shape Using Computed Tomography Imaging.[NCT02771171]60 participants (Actual)Observational2016-04-30Completed
Comparison Between Two Endotracheal Tube Cuff Inflation Methods; Flow Volume Loop Guided vs. Just Seal by Stethoscope Guided in Pediatric Patients[NCT03902756]80 participants (Actual)Interventional2018-06-05Completed
Changes of Hemodynamics and Vital Organ Function in Intracerebral Hemorrhage During Different General Anesthesia[NCT03129009]90 participants (Anticipated)Interventional2017-04-01Recruiting
Fentanyl Effect on Blood Pressure in Elderly Patients After Induction of General Anesthesia[NCT02489019]Phase 2/Phase 3105 participants (Anticipated)Interventional2018-02-19Recruiting
Focussed Echocardiography to Detect Preoperative Hypovolemia and Left Ventricular Dysfunction as a Predictor of Post-Induction Hypotension[NCT02944266]150 participants (Anticipated)Observational2016-01-31Recruiting
Perfusion Index as a Predictor of Hypotension Following Propofol Induction of General Anesthesia in Geriatric Patients - A Prospective Observational Study.[NCT04682717]30 participants (Actual)Observational2020-12-01Completed
Comparison of Leg Elevation and Leg Wrapping in the Prevention of Propofol Induced Hypotension: A Prospective Randomised Controlled Study[NCT02845921]150 participants (Anticipated)Interventional2016-01-31Recruiting
Effect of the Pneumatic Compression of Lower Leg on Post-induction Hypotension in Elderly Patients Undergoing Robot Assisted Laparoscopic Prostatectomy: a Double Blined Randomized Controlled Trial[NCT05343689]100 participants (Actual)Interventional2022-05-04Completed
"PGDT With the Hypotension Prediction Index to Reduce the Number and Duration of Intraoperative Hypotension and the Incidence of Renal Failure in Patients Undergoing Lung Surgery"[NCT04149314]142 participants (Actual)Interventional2019-11-20Completed
Compare the Side Effects and Differences Awake Level of Propofol by Using Three TCI Formula of Anesthesia in TVOR Patients[NCT00760253]118 participants (Actual)Observational2008-09-30Completed
A Prospective Comparison of the Airway Deadspace Associated With the Air-Q® and Endotracheal Tube Using Volumetric Capnography in Young Children[NCT03785977]62 participants (Actual)Observational2019-03-25Completed
Evaluation of the Impact of Adding Remifentanil to Propofol on the Conditions of the Diagnostic Panendoscopy of the Upper Airway Under General Anesthesia With Tubeless Spontaneous Ventilation.[NCT02093143]Phase 3256 participants (Actual)Interventional2009-06-30Completed
Investigation on the Pharmacokinetic and -Dynamic of Propofol During Awake Craniotomy[NCT01128465]10 participants (Anticipated)Observational2010-02-28Completed
Comparison of Ephedrine Versus Norepinephrine Efficacity to Correct Anesthesia Induction Related Hypotension in Chronic Renal Insufficiency Patients[NCT05497700]Phase 360 participants (Anticipated)Interventional2022-09-15Recruiting
Pharmacokinetic and Pharmacodynamic of Rocuronium Bromide Measured in Adductor Pollicis and Masseter Muscles.[NCT02376595]10 participants (Actual)Observational2013-03-31Completed
Study of the Effect of Intraoperative Positive Messages on Postoperative Outcomes[NCT02765750]5 participants (Actual)Interventional2016-03-31Terminated (stopped due to The primary investigator was transferred to another hospital)
Effect of Gender on the Pharmacokinetics-pharmacodynamics of Propofol and Cisatracurium Besylate[NCT02588118]120 participants (Actual)Observational2010-01-31Completed
Neuromodulation With Percutaneous Electrical Nerve Field Stimulation for Adults With COVID-19[NCT04514627]100 participants (Anticipated)Interventional2020-07-13Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for propofol and Aging

ArticleYear
The EEG signal: a window on the cortical brain activity.
    Paediatric anaesthesia, 2012, Volume: 22, Issue:6

    Topics: Adult; Aging; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Cerebral Cortex; Child;

2012
Clinically important drug interactions with intravenous anaesthetics in older patients.
    Drugs & aging, 2003, Volume: 20, Issue:13

    Topics: Aged; Aging; Anesthetics, Intravenous; Barbiturates; Benzodiazepines; Drug Interactions; Etomidate;

2003
Pharmacokinetic implications for the clinical use of propofol.
    Clinical pharmacokinetics, 1989, Volume: 17, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics; Blood Proteins; Child; Child, Preschool; Dose-Response Relationship

1989

Trials

23 trials available for propofol and Aging

ArticleYear
The Effects of Propofol and Sevoflurane on Postoperative Delirium in Older Patients: A Randomized Clinical Trial Study.
    Journal of Alzheimer's disease : JAD, 2020, Volume: 76, Issue:4

    Topics: Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intra

2020
Age influences on Propofol estimated brain concentration and entropy during maintenance and at return of consciousness during total intravenous anesthesia with target-controlled infusion in unparalyzed patients: An observational prospective trial.
    PloS one, 2020, Volume: 15, Issue:12

    Topics: Aged; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Brain; Consciousness; Electroencepha

2020
Effects of aging and propofol on the cardiovascular component of the autonomic nervous system.
    Journal of clinical anesthesia, 2013, Volume: 25, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Intravenous; Autonomic Nervous System; Blood Pre

2013
[EEG-adjusted target-controlled infusion : Propofol target concentration with different doses of remifentanil].
    Der Anaesthesist, 2010, Volume: 59, Issue:2

    Topics: Adult; Aged; Aging; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; B

2010
Lipid-emulsion propofol less attenuates the regulation of body temperature than micro-emulsion propofol or sevoflurane in the elderly.
    Yonsei medical journal, 2012, Volume: 53, Issue:1

    Topics: Aged; Aging; Anesthesia, General; Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intra

2012
Effect of age on the comparability of bispectral and state entropy indices during the maintenance of propofol-sufentanil anaesthesia.
    British journal of anaesthesia, 2012, Volume: 108, Issue:4

    Topics: Age Factors; Aging; Anesthesia, General; Anesthetics, Combined; Anesthetics, Intravenous; Electroenc

2012
[Neuromuscular blockade with cisatracurium in infants andchildren. Its course under sevoflurane anesthesia].
    Der Anaesthesist, 2002, Volume: 51, Issue:5

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intrav

2002
Recovery of psychomotor function after propofol sedation is prolonged in the elderly.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2002, Volume: 49, Issue:9

    Topics: Adult; Aged; Aging; Anesthesia Recovery Period; Anesthesia, Spinal; Conscious Sedation; Electroencep

2002
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
    Anesthesiology, 2003, Volume: 98, Issue:1

    Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc

2003
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
    Anesthesiology, 2003, Volume: 98, Issue:1

    Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc

2003
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
    Anesthesiology, 2003, Volume: 98, Issue:1

    Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc

2003
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
    Anesthesiology, 2003, Volume: 98, Issue:1

    Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc

2003
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
    Anesthesiology, 2003, Volume: 98, Issue:1

    Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc

2003
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
    Anesthesiology, 2003, Volume: 98, Issue:1

    Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc

2003
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
    Anesthesiology, 2003, Volume: 98, Issue:1

    Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc

2003
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
    Anesthesiology, 2003, Volume: 98, Issue:1

    Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc

2003
Developmental changes of laryngeal dimensions in unparalyzed, sedated children.
    Anesthesiology, 2003, Volume: 98, Issue:1

    Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Child; Child, Preschool; Consc

2003
The effects of clonidine premedication on the blood pressure and tachycardiac responses to ephedrine in elderly and young patients during propofol anesthesia.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:1

    Topics: Adjuvants, Anesthesia; Adrenergic alpha-Agonists; Adult; Aged; Aging; Anesthesia, Intravenous; Anest

2003
Age-related effects in the EEG during propofol anaesthesia.
    Acta anaesthesiologica Scandinavica, 2004, Volume: 48, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthet

2004
Onset and offset pharmacodynamics of propofol.
    Die Pharmazie, 2004, Volume: 59, Issue:1

    Topics: Adipose Tissue; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Intravenous; Body Co

2004
Propofol sedation for longitudinal pediatric neuroimaging research.
    Journal of neurosurgical anesthesiology, 2005, Volume: 17, Issue:4

    Topics: Aging; Anesthetics, Intravenous; Blood Pressure; Child; Child, Preschool; Conscious Sedation; Female

2005
Influence of aging on lidocaine requirements for pain on injection of propofol.
    Journal of clinical anesthesia, 2006, Volume: 18, Issue:7

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Anesthetics, Intravenou

2006
Age-related differences in metoclopramide requirement for pain on injection of propofol.
    Clinical drug investigation, 2006, Volume: 26, Issue:11

    Topics: Adult; Aged; Aging; Double-Blind Method; Female; Humans; Injections; Male; Metoclopramide; Middle Ag

2006
Plasma concentrations of brain-derived neurotrophic factor in patients undergoing minor surgery: a randomized controlled trial.
    Neurochemical research, 2008, Volume: 33, Issue:7

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Inhalation; Anestheti

2008
[Age-related correlation between EEG parameters and depth of anesthesia under propofol. Effect of fentanyl].
    Der Anaesthesist, 1996, Volume: 45, Issue:8

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aging; Anesthetics, Combined; Anesthetics, Intravenous; El

1996
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers.
    Anesthesiology, 1998, Volume: 88, Issue:5

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Antidotes; Cross-Over Studies; Double-Blind Method; Dr

1998
Comparison of the intubation conditions provided by rapacuronium (ORG 9487) or succinylcholine in humans during anesthesia with fentanyl and propofol.
    Anesthesiology, 1999, Volume: 91, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Combined; Anesthetics, Intravenous;

1999
Population pharmacokinetics of propofol: a multicenter study.
    Anesthesiology, 2000, Volume: 92, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Algorithms; Anesthetics, Intravenous; Body Weight

2000
The combined effect of age and premedication on the propofol requirements for induction by target-controlled infusion.
    Anesthesia and analgesia, 2000, Volume: 90, Issue:5

    Topics: Adjuvants, Anesthesia; Adult; Aged; Aging; Analgesics, Opioid; Anesthetics, Intravenous; Blood Press

2000
Effect of midazolam pretreatment on induction dose requirements of propofol in combination with fentanyl in younger and older adults.
    Anaesthesia, 2001, Volume: 56, Issue:2

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aging; Analysis of Variance; Anesthetics, Intravenou

2001
Postoperative reading speed does not indicate implicit memory in elderly cardiac patients after propofol and remifentanyl anaesthesia.
    Acta anaesthesiologica Scandinavica, 2001, Volume: 45, Issue:6

    Topics: Acoustic Stimulation; Adult; Aged; Aging; Anesthesia, Intravenous; Anesthetics, Intravenous; Awarene

2001

Other Studies

66 other studies available for propofol and Aging

ArticleYear
Avenanthramide-C Activates Nrf2/ARE Pathway and Inhibiting Ferroptosis Pathway to Improve Cognitive Dysfunction in Aging Rats.
    Neurochemical research, 2023, Volume: 48, Issue:2

    Topics: Aging; Animals; Cognitive Dysfunction; Ferroptosis; Hippocampus; Neuroinflammatory Diseases; NF-E2-R

2023
Age progression from vicenarians (20-29 year) to nonagenarians (90-99 year) among a population pharmacokinetic/pharmacodynamic (PopPk-PD) covariate analysis of propofol-bispectral index (BIS) electroencephalography.
    Journal of pharmacokinetics and pharmacodynamics, 2020, Volume: 47, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous

2020
A longitudinal, multi-parametric functional MRI study to determine age-related changes in the rodent brain.
    NeuroImage, 2020, Volume: 218

    Topics: Aging; Anesthetics, Intravenous; Animals; Brain; Female; Longitudinal Studies; Magnetic Resonance Im

2020
Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a "Vulnerable Brain".
    Anesthesia and analgesia, 2020, Volume: 131, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alpha Rhythm; Anesthesia; Anesthetics, Intravenou

2020
Repeated propofol exposure-induced neuronal damage and cognitive impairment in aged rats by activation of NF-κB pathway and NLRP3 inflammasome.
    Neuroscience letters, 2021, 01-01, Volume: 740

    Topics: Aging; Anesthetics, Intravenous; Animals; Cognition; Cognition Disorders; Conditioning, Operant; Hip

2021
Impact of aging on interactions between opioid and propofol concentrations during total intravenous anesthesia.
    Journal of clinical anesthesia, 2021, Volume: 71

    Topics: Aging; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; Humans; Propofol

2021
Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice.
    Current Alzheimer research, 2019, Volume: 16, Issue:1

    Topics: Administration, Intranasal; Aging; Anesthesia; Anesthetics, Intravenous; Animals; Brain; Cognitive D

2019
Control of depth of anaesthesia using fractional-order adaptive high-gain controller.
    IET systems biology, 2019, Volume: 13, Issue:1

    Topics: Aging; Anesthesia; Body Height; Female; Humans; Male; Models, Biological; Propofol; Sex Characterist

2019
Propofol increases vascular relaxation in aging rats chronically treated with the angiotensin-converting enzyme inhibitor captopril.
    Anesthesia and analgesia, 2013, Volume: 116, Issue:4

    Topics: Aging; Anesthetics, Intravenous; Angiotensin-Converting Enzyme Inhibitors; Animals; Area Under Curve

2013
General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt.
    British journal of anaesthesia, 2013, Volume: 110 Suppl 1

    Topics: Aging; Anesthetics, Intravenous; Animals; Animals, Newborn; Female; Gene Expression Regulation, Deve

2013
Effects of isoflurane or propofol on postnatal hippocampal neurogenesis in young and aged rats.
    Brain research, 2013, Sep-12, Volume: 1530

    Topics: Aging; Anesthesia, General; Anesthetics, Inhalation; Animals; Cell Differentiation; Cell Proliferati

2013
Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice.
    Journal of Alzheimer's disease : JAD, 2014, Volume: 41, Issue:2

    Topics: Aging; Alzheimer Disease; Amyloidogenic Proteins; Animals; Brain; Caspases; Cell Line, Tumor; Cognit

2014
A general purpose pharmacokinetic model for propofol.
    Anesthesia and analgesia, 2014, Volume: 118, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Algorithms; Anesthesia, Intravenous;

2014
Propofol selectively alters GluA1 AMPA receptor phosphorylation in the hippocampus but not prefrontal cortex in young and aged mice.
    European journal of pharmacology, 2014, Sep-05, Volume: 738

    Topics: Aging; Anesthetics, General; Animals; Mice; Phosphorylation; Prefrontal Cortex; Propofol; Receptors,

2014
Propofol-induced relaxation of rat aorta is altered by aging.
    The journal of medical investigation : JMI, 2014, Volume: 61, Issue:3-4

    Topics: Aging; Anesthetics, Intravenous; Animals; Aorta, Thoracic; Male; NG-Nitroarginine Methyl Ester; Nitr

2014
Propofol-induced age-different hypocampal long-term potentiation is associated with F-actin polymerization in rats.
    Cell biochemistry and biophysics, 2015, Volume: 71, Issue:2

    Topics: Actins; Aging; Anesthetics, Intravenous; Animals; CA1 Region, Hippocampal; Cognition; Long-Term Pote

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Electroencephal

2015
Ageing delays emergence from general anaesthesia in rats by increasing anaesthetic sensitivity in the brain.
    British journal of anaesthesia, 2015, Volume: 115 Suppl 1

    Topics: Aging; Anesthesia, General; Anesthetics; Animals; Brain; Electroencephalography; Isoflurane; Male; M

2015
Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice.
    Journal of clinical anesthesia, 2016, Volume: 33

    Topics: Adult; Aged; Aged, 80 and over; Aging; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous

2016
The ageing brain.
    British journal of anaesthesia, 2016, Volume: 117, Issue:5

    Topics: Aging; Anesthesia, General; Brain; Electroencephalography; Propofol; Sevoflurane

2016
Spatial memory is intact in aged rats after propofol anesthesia.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:4

    Topics: Aging; Anesthesia, General; Anesthetics, Intravenous; Animals; Maze Learning; Memory; Propofol; Rats

2008
GABAergic mechanism of propofol toxicity in immature neurons.
    Journal of neurosurgical anesthesiology, 2008, Volume: 20, Issue:4

    Topics: Aging; Anesthetics, Intravenous; Animals; Calcium; Calcium Channel Agonists; Calcium Channels, L-Typ

2008
Urinary propofol metabolites in early life after single intravenous bolus.
    British journal of anaesthesia, 2008, Volume: 101, Issue:6

    Topics: Aging; Anesthetics, Intravenous; Body Weight; Humans; Hydroquinones; Infant; Infant, Newborn; Metabo

2008
The effects of propofol on vascular function in mesenteric arteries of the aging rat.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:1

    Topics: Acetylcholine; Aging; Animals; Antioxidants; Biological Factors; Dose-Response Relationship, Drug; E

2009
Bispectral and spectral entropy indices at propofol-induced loss of consciousness in young and elderly patients.
    British journal of anaesthesia, 2009, Volume: 103, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Intravenous; Consciousness; Drug Administration

2009
Bedside prediction of airway length in adults and children.
    Anesthesiology, 2009, Volume: 111, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Algorithms; Androstanols; Anesthesia, General; Anesthetics, Intraven

2009
The effect of a target controlled infusion of propofol on predictability of recovery from anesthesia in children.
    Paediatric anaesthesia, 2010, Volume: 20, Issue:1

    Topics: Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intrav

2010
[Comparative study of induction time using propofol bolus injection in elderly patients].
    Masui. The Japanese journal of anesthesiology, 2010, Volume: 59, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthetics,

2010
Clinically relevant asymmetry of bispectral index during recovery from anaesthesia for ear-nose-throat surgery in adults and children.
    Anaesthesia, 2011, Volume: 66, Issue:10

    Topics: Adult; Aging; Anesthesia; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation;

2011
A bodyweight-dependent allometric exponent for scaling clearance across the human life-span.
    Pharmaceutical research, 2012, Volume: 29, Issue:6

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anesthetics, Intravenous; Body Weigh

2012
Quantitative assessment of new cell proliferation in the dentate gyrus and learning after isoflurane or propofol anesthesia in young and aged rats.
    Brain research, 2012, Mar-02, Volume: 1441

    Topics: Aging; Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Cell Proliferation; Dentate Gyrus;

2012
Changes of learning and memory in aged rats after isoflurane inhalational anaesthesia correlated with hippocampal acetylcholine level.
    Annales francaises d'anesthesie et de reanimation, 2012, Volume: 31, Issue:3

    Topics: Acetylcholine; Aging; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Brain Chemi

2012
[Recovery from total intravenous anesthesia with propofol and buprenorphine].
    Masui. The Japanese journal of anesthesiology, 2002, Volume: 51, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia Recovery Period; Anesthesia, Intraveno

2002
Target-controlled infusion of propofol and remifentanil in cardiac anaesthesia: influence of age on predicted effect-site concentrations.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anesthetics, Combined; Anesthetics,

2003
Propofol enhances ischemic tolerance of middle-aged rat hearts: effects on 15-F(2t)-isoprostane formation and tissue antioxidant capacity.
    Cardiovascular research, 2003, Jul-01, Volume: 59, Issue:1

    Topics: Aging; Animals; Antioxidants; Disease Susceptibility; Male; Myocardial Ischemia; Myocardial Reperfus

2003
Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics.
    Anesthesiology, 2003, Volume: 99, Issue:2

    Topics: Aging; Algorithms; Anesthetics, Intravenous; Computer Simulation; Data Interpretation, Statistical;

2003
Autonomic mechanisms in the age-related hypotensive effect of propofol.
    Anesthesia and analgesia, 2005, Volume: 100, Issue:1

    Topics: Aging; Anesthetics, Intravenous; Animals; Autonomic Nervous System; Baroreflex; Blood Pressure; Dose

2005
Impact of patient age on propofol consumption during propofol-remifentanil anaesthesia.
    European journal of anaesthesiology, 2005, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia Recovery Period; Anesthesia, Intraveno

2005
Allometric relationships between the pharmacokinetics of propofol in rats, children and adults.
    British journal of clinical pharmacology, 2005, Volume: 59, Issue:6

    Topics: Adult; Aged; Aging; Anesthetics, Intravenous; Animals; Body Weight; Child, Preschool; Drug Evaluatio

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Predictors of hypotension after induction of general anesthesia.
    Anesthesia and analgesia, 2005, Volume: 101, Issue:3

    Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr

2005
Pharmacokinetics of a single bolus of propofol in chinese children of different ages.
    Anesthesiology, 2006, Volume: 104, Issue:1

    Topics: Aging; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous; Body Weight; Child; Child, Pre

2006
The kinetics of Ringer's solution in young and elderly patients during induction of general anesthesia with propofol and epidural anesthesia with ropivacaine.
    Acta anaesthesiologica Scandinavica, 2007, Volume: 51, Issue:7

    Topics: Adult; Aged; Aging; Algorithms; Amides; Anesthesia, Epidural; Anesthesia, General; Anesthetics, Intr

2007
Inter-individual variability in propofol pharmacokinetics in preterm and term neonates.
    British journal of anaesthesia, 2007, Volume: 99, Issue:6

    Topics: Aging; Anesthetics, Intravenous; Body Weight; Creatinine; Drug Administration Schedule; Female; Gest

2007
EEG variables as measures of arousal during propofol anaesthesia for general surgery in children: rational selection and age dependence.
    British journal of anaesthesia, 2007, Volume: 99, Issue:6

    Topics: Adolescent; Aging; Anesthesia, General; Anesthetics, Combined; Anesthetics, Intravenous; Arousal; Bl

2007
Variation of bispectral index under TIVA with propofol in a paediatric population.
    British journal of anaesthesia, 2008, Volume: 100, Issue:1

    Topics: Adolescent; Aging; Anesthetics, Intravenous; Blood Pressure; Child; Child, Preschool; Dose-Response

2008
Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children.
    British journal of anaesthesia, 2008, Volume: 100, Issue:4

    Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Intravenous; Blood P

2008
Volumetric capnography in children. Influence of growth on the alveolar plateau slope.
    Anesthesiology, 1995, Volume: 82, Issue:1

    Topics: Adolescent; Aging; Anesthesia; Body Constitution; Carbon Dioxide; Child; Child, Preschool; Halothane

1995
[Use of Diprivan in the elderly].
    Annales francaises d'anesthesie et de reanimation, 1994, Volume: 13, Issue:4

    Topics: Age Factors; Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Hemodynamics; Humans; Propofol

1994
[Total intravenous anesthesia (TIVA) with propofol in the elderly patient].
    Minerva anestesiologica, 1993, Volume: 59, Issue:11

    Topics: Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Central Nervous System; Female; Humans; Mal

1993
The effects of verapamil and lidocaine on the duration of propofol and xylazine-ketamine anesthesia in broiler chickens.
    Veterinary and human toxicology, 1996, Volume: 38, Issue:3

    Topics: Aging; Analysis of Variance; Anesthesia; Anesthetics; Animals; Calcium Channel Blockers; Chickens; D

1996
Age-dependent development of acute tolerance to propofol and its distribution in a pharmacokinetic compartment-independent rat model.
    Acta anaesthesiologica Scandinavica, 1996, Volume: 40, Issue:6

    Topics: Aging; Anesthetics, Intravenous; Animals; Chromatography, High Pressure Liquid; Drug Tolerance; Elec

1996
Pharmacokinetics of propofol as an induction agent in geriatric dogs.
    Research in veterinary science, 1996, Volume: 61, Issue:2

    Topics: Aging; Animals; Dogs; Injections, Intravenous; Metabolic Clearance Rate; Propofol; Species Specifici

1996
Age-related propofol effects on electrophysiological properties of isolated hearts.
    Anesthesia and analgesia, 1997, Volume: 84, Issue:5

    Topics: Aging; Anesthetics, Intravenous; Animals; Animals, Newborn; Atrial Function; Atrioventricular Node;

1997
The influence of age and administration rate on the brain sensitivity to propofol in rats.
    Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:8

    Topics: Aging; Anesthesia; Anesthetics, Intravenous; Animals; Body Weight; Brain; Dose-Response Relationship

1998
Aging decreases the sensitivity of the GABA carrier to propofol and etomidate.
    British journal of anaesthesia, 1998, Volume: 81, Issue:2

    Topics: Aging; Anesthetics, Intravenous; Animals; Cell Culture Techniques; Etomidate; gamma-Aminobutyric Aci

1998
Aging prolongs recovery of psychomotor functions at emergence from propofol-alfentanil anaesthesia.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:12

    Topics: Adult; Aged; Aging; Alfentanil; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, In

1998
GABA(A) receptor in growth cones: the outline of GABA(A) receptor-dependent signaling in growth cones is applicable to a variety of alpha-subunit species.
    Journal of neuroscience research, 1999, Nov-01, Volume: 58, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Calcium; Cerebral Cortex; Chlorides; Diazepam; Fetus; gamma-Aminob

1999
[The influence of age on hemodynamics and the dose requirements of propofol and buprenorphine in total intravenous anesthesia].
    Masui. The Japanese journal of anesthesiology, 2001, Volume: 50, Issue:1

    Topics: Adult; Aged; Aging; Anesthesia Recovery Period; Anesthesia, Intravenous; Body Weight; Buprenorphine;

2001
[The influence of age on hemodynamics and the dose requirements of propofol and buprenorphine in total intravenous anesthesia combined with continuous epidural anesthesia].
    Masui. The Japanese journal of anesthesiology, 2001, Volume: 50, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia,

2001
Gender differences in the pharmacokinetics of propofol in elderly patients during and after continuous infusion.
    British journal of anaesthesia, 2001, Volume: 86, Issue:2

    Topics: Aged; Aged, 80 and over; Aging; Anesthetics, Intravenous; Body Weight; Computer Simulation; Female;

2001
Plasma proinflammatory cytokine response to surgical stress in elderly patients.
    Cytokine, 2001, Sep-07, Volume: 15, Issue:5

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anesthetics, Inhalation; Anesthetics, Intravenou

2001
Direct effects of propofol on myocardial and vascular tissue from mature and immature rats.
    Journal of cardiothoracic and vascular anesthesia, 2001, Volume: 15, Issue:6

    Topics: Aging; Anesthetics, Intravenous; Animals; Aorta, Thoracic; Depression, Chemical; Dose-Response Relat

2001
[Propofol anesthesia for ophthalmologic surgery in the elderly].
    Cahiers d'anesthesiologie, 1992, Volume: 40, Issue:1

    Topics: Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Cataract Extraction; Humans; Propofol; Reti

1992
The induction dose of propofol in infants 1-6 months of age and in children 10-16 years of age.
    Anesthesiology, 1991, Volume: 74, Issue:3

    Topics: Adolescent; Aging; Anesthesia, Intravenous; Blood Pressure; Child; Dose-Response Relationship, Drug;

1991
Lean tissue mass is a useful predictor of induction dose requirements for propofol.
    Anaesthesia and intensive care, 1991, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthesia, Intravenous; Body Composition; Female

1991
Pharmacokinetics of propofol (diprivan) in elderly patients.
    British journal of anaesthesia, 1988, Volume: 60, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Anesthetics; Humans; Phenols; Propofol

1988