Page last updated: 2024-10-20

propionic acid and Obesity

propionic acid has been researched along with Obesity in 16 studies

propionic acid : A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
" The present study thus evaluates the synergistic effect of probiotic Enterococcus faecalis AG5 on HFD induced obesity and the role of propionic acid (PA) in apoptosis induction of 3T3-L1 pre-adipocyte."7.96Probiotic Enterococcus faecalis AG5 mitigated high fat diet induced obesity and produced propionic acid stimulated apoptosis in 3T3-L1 pre-adipocyte. ( Ghosh, AR; Mishra, AK, 2020)
"Acetic acid, propionic acid, butyric acid, and total SCFA were significantly reduced in T2D patients compared to overweight/obese in the unadjusted model."4.12Circulating short-chain fatty acids in type 2 diabetic patients and overweight/obese individuals. ( Annuzzi, G; Bozzetto, L; Corrado, A; Costabile, G; Della Pepa, G; Giacco, R; Luongo, D; Rivellese, AA; Salamone, D; Testa, R; Vitale, M, 2022)
"Obesity is one of the major health problems throughout the world."1.42Supplemental epilactose prevents metabolic disorders through uncoupling protein-1 induction in the skeletal muscle of mice fed high-fat diets. ( Matsui, H; Mori, H; Murakami, Y; Ojima-Kato, T; Saburi, W; Suzuki, T; Tanabe, S, 2015)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.25)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's9 (56.25)24.3611
2020's6 (37.50)2.80

Authors

AuthorsStudies
Salamone, D1
Costabile, G1
Corrado, A1
Della Pepa, G1
Vitale, M1
Giacco, R1
Luongo, D1
Testa, R1
Rivellese, AA1
Annuzzi, G1
Bozzetto, L1
Rad, ZA1
Mousavi, SN1
Chiti, H1
Tengeler, AC1
Gart, E1
Wiesmann, M1
Arnoldussen, IAC1
van Duyvenvoorde, W1
Hoogstad, M1
Dederen, PJ1
Verweij, V1
Geenen, B1
Kozicz, T1
Kleemann, R1
Morrison, MC1
Kiliaan, AJ1
Mishra, AK1
Ghosh, AR1
Sun, B1
Vatanen, T1
Jayasinghe, TN1
McKenzie, E1
Murphy, R1
O'Sullivan, JM1
Liang, D1
Zhang, L1
Chen, H1
Zhang, H1
Hu, H1
Dai, X1
Canfora, EE1
van der Beek, CM1
Jocken, JWE1
Goossens, GH1
Holst, JJ2
Olde Damink, SWM1
Lenaerts, K1
Dejong, CHC1
Blaak, EE1
Byrne, CS1
Chambers, ES1
Preston, T1
Tedford, C1
Brignardello, J1
Garcia-Perez, I1
Holmes, E1
Wallis, GA1
Morrison, DJ1
Frost, GS2
Duan, Y1
Zhong, Y1
Xiao, H1
Zheng, C1
Song, B1
Wang, W1
Guo, Q1
Li, Y1
Han, H1
Gao, J1
Xu, K1
Li, T1
Yin, Y1
Li, F1
Yin, J1
Kong, X1
Murakami, Y1
Ojima-Kato, T1
Saburi, W1
Mori, H1
Matsui, H1
Tanabe, S1
Suzuki, T1
Aguirre, M1
Bussolo de Souza, C1
Venema, K2
Al-Lahham, SH1
Peppelenbosch, MP1
Roelofsen, H1
Vonk, RJ1
Verbrugghe, A1
Hesta, M1
Daminet, S1
Polis, I1
Buyse, J1
Wuyts, B1
Janssens, GP1
Darzi, J1
Robertson, MD1
Okazaki, Y1
Sitanggang, NV1
Sato, S1
Ohnishi, N1
Inoue, J1
Iguchi, T1
Watanabe, T1
Tomotake, H1
Harada, K1
Kato, N1
ANNONI, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Using a Complex Carbohydrate Mixture Added to a High-protein Diet to Steer Fermentation and Improve Metabolic, Gut and Brain Health[NCT05354245]44 participants (Anticipated)Interventional2022-09-08Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for propionic acid and Obesity

ArticleYear
Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms.
    Biochimica et biophysica acta, 2010, Volume: 1801, Issue:11

    Topics: Adipose Tissue; Animals; Child; Child Development Disorders, Pervasive; Colon; Diabetes Mellitus, Ty

2010

Trials

4 trials available for propionic acid and Obesity

ArticleYear
Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial.
    Scientific reports, 2017, 05-24, Volume: 7, Issue:1

    Topics: Acetic Acid; Adult; Butyric Acid; Colon; Cross-Over Studies; Double-Blind Method; Energy Metabolism;

2017
Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study.
    Nutrients, 2019, Apr-16, Volume: 11, Issue:4

    Topics: Anti-Obesity Agents; Appetite; Basal Metabolism; Calorimetry, Indirect; Colon; Cross-Over Studies; D

2019
Propionate absorbed from the colon acts as gluconeogenic substrate in a strict carnivore, the domestic cat (Felis catus).
    Journal of animal physiology and animal nutrition, 2012, Volume: 96, Issue:6

    Topics: Absorption; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Cats; Colon; Cross-Ove

2012
Effects of a novel propionate-rich sourdough bread on appetite and food intake.
    European journal of clinical nutrition, 2012, Volume: 66, Issue:7

    Topics: Adult; Appetite; Blood Glucose; Bread; Consumer Behavior; Diet; Energy Intake; Female; Food Preferen

2012

Other Studies

11 other studies available for propionic acid and Obesity

ArticleYear
Circulating short-chain fatty acids in type 2 diabetic patients and overweight/obese individuals.
    Acta diabetologica, 2022, Volume: 59, Issue:12

    Topics: Acetic Acid; Butyric Acid; Diabetes Mellitus, Type 2; Fatty Acids, Volatile; Humans; Obesity; Overwe

2022
A low-carb diet increases fecal short-chain fatty acids in feces of obese women following a weight-loss program: randomized feeding trial.
    Scientific reports, 2023, 10-24, Volume: 13, Issue:1

    Topics: Acetic Acid; Butyric Acid; Diet; Fatty Acids, Volatile; Feces; Female; Humans; Insulins; Interleukin

2023
Propionic acid and not caproic acid, attenuates nonalcoholic steatohepatitis and improves (cerebro) vascular functions in obese Ldlr
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, Volume: 34, Issue:7

    Topics: Animals; Caproates; Cerebrovascular Disorders; Diet, Fat-Restricted; Diet, High-Fat; Inflammation; M

2020
Probiotic Enterococcus faecalis AG5 mitigated high fat diet induced obesity and produced propionic acid stimulated apoptosis in 3T3-L1 pre-adipocyte.
    Life sciences, 2020, Nov-15, Volume: 261

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Apoptosis; Diet, High-Fat; Enterococcus faecalis; Flow Cytometry;

2020
Desacetyl-α-MSH and α-MSH have sex specific interactions with diet to influence mouse gut morphology, metabolites and microbiota.
    Scientific reports, 2020, 11-03, Volume: 10, Issue:1

    Topics: Acetic Acid; alpha-MSH; Animals; Diet, High-Fat; Female; Gastrointestinal Microbiome; Genotype; Male

2020
Potato resistant starch inhibits diet-induced obesity by modifying the composition of intestinal microbiota and their metabolites in obese mice.
    International journal of biological macromolecules, 2021, Jun-01, Volume: 180

    Topics: Acetic Acid; Animals; Bacteroides; Bifidobacterium; Body Weight; Diet, High-Fat; Gastrointestinal Mi

2021
Gut microbiota mediates the protective effects of dietary β-hydroxy-β-methylbutyrate (HMB) against obesity induced by high-fat diets.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:9

    Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Bacteroidetes; Diet, High-Fat; Dysbiosis; Fatty Acid

2019
Supplemental epilactose prevents metabolic disorders through uncoupling protein-1 induction in the skeletal muscle of mice fed high-fat diets.
    The British journal of nutrition, 2015, Dec-14, Volume: 114, Issue:11

    Topics: Adipose Tissue, Brown; Adipose Tissue, White; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti

2015
The Gut Microbiota from Lean and Obese Subjects Contribute Differently to the Fermentation of Arabinogalactan and Inulin.
    PloS one, 2016, Volume: 11, Issue:7

    Topics: Acetates; Adult; Bifidobacterium; Butyrates; Dietary Fiber; Energy Metabolism; Female; Fermentation;

2016
Burdock fermented by Aspergillus awamori elevates cecal Bifidobacterium, and reduces fecal deoxycholic acid and adipose tissue weight in rats fed a high-fat diet.
    Bioscience, biotechnology, and biochemistry, 2013, Volume: 77, Issue:1

    Topics: Acetic Acid; Adipose Tissue; Animals; Arctium; Aspergillus; Bifidobacterium; Butyric Acid; Cecum; De

2013
[ACTION OF A SYNTHETIC ANTICHOLESTEROLEMIC DRUG, 2-(4-BIPHENYLYL)-PROPIONIC ACID, IN OBESITY].
    La Clinica terapeutica, 1963, Aug-15, Volume: 26

    Topics: Antimetabolites; Biphenyl Compounds; Cholesterol; Coronary Disease; Humans; Hypertension; Obesity; P

1963