propionic acid has been researched along with Disease Models, Animal in 46 studies
propionic acid : A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our findings show that intracerebroventricular injection of streptozotocin accelerated cognitive dysfunction associated with increasing levels of glycogen synthase kinase 3 beta (GSK3β) activity, tau protein phosphorylation at the T231 site (pT231), amyloid-β (Aβ) deposition, amyloid-β protein precursor (AβPP), β-site AβPP-cleaving enzyme (BACE1), gliosis, fecal propionic acid (PPA) levels and cognition-related neuronal loss and decreasing postsynaptic density protein 95 (PSD95) levels in 3 × Tg-AD mice." | 8.02 | Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer's disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis. ( Chen, JL; Chen, YH; Chieu, MW; Hsieh-Li, HM; Hsu, CC; Huang, HJ; Ke, YY; Liao, JF; Tsai, YC, 2021) |
| " In this paper, we have assessed the impact of citrus pectin and modified citrus pectin on colorectal cancer in rats (Rattus norvegicus F344) to which azoxymethane and DSS were supplied." | 8.02 | Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model. ( Fernández, J; Ferreira-Lazarte, A; Gallego-Lobillo, P; Lombó, F; Moreno, FJ; Villamiel, M; Villar, CJ, 2021) |
| " The present study was conducted to find the effect of probiotics and prebiotics in balancing the gut flora in a rodent model of autism linked with a clindamycin-induced altered gut." | 7.91 | Ameliorative effect of probiotics (Lactobacillus paracaseii and Protexin®) and prebiotics (propolis and bee pollen) on clindamycin and propionic acid-induced oxidative stress and altered gut microbiota in a rodent model of autism. ( Aabed, K; Al-Marshoud, M; Al-Mutiri, M; Al-Qahtani, A; Ansary, A; Moubayed, N; Shafi Bhat, R, 2019) |
| "Treatment with pioglitazone, significantly attenuated the postnatal propionic acid-induced social impairment, repetitive behavior, hyperactivity, anxiety and low exploratory activity." | 5.51 | A selective peroxisome proliferator-activated receptor-γ agonist benefited propionic acid induced autism-like behavioral phenotypes in rats by attenuation of neuroinflammation and oxidative stress. ( Mirza, R; Sharma, B, 2019) |
| "Propionic acid (PPA) is a short chain fatty acid, a metabolic end-product of enteric bacteria in the gut, and a common food preservative." | 5.35 | Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism. ( Cain, DP; MacFabe, DF; Ossenkopp, KP; Scratch, S; Shultz, SR; Taylor, R; Whelan, J, 2008) |
| "Propionic acid (PPA) is a short chain fatty acid and an important intermediate of cellular metabolism." | 5.34 | Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. ( Boon, F; Cain, DP; Franklin, AE; Hoffman, JE; Kavaliers, M; MacFabe, DF; Ossenkopp, KP; Rodriguez-Capote, K; Taylor, AR, 2007) |
| "Our findings show that intracerebroventricular injection of streptozotocin accelerated cognitive dysfunction associated with increasing levels of glycogen synthase kinase 3 beta (GSK3β) activity, tau protein phosphorylation at the T231 site (pT231), amyloid-β (Aβ) deposition, amyloid-β protein precursor (AβPP), β-site AβPP-cleaving enzyme (BACE1), gliosis, fecal propionic acid (PPA) levels and cognition-related neuronal loss and decreasing postsynaptic density protein 95 (PSD95) levels in 3 × Tg-AD mice." | 4.02 | Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer's disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis. ( Chen, JL; Chen, YH; Chieu, MW; Hsieh-Li, HM; Hsu, CC; Huang, HJ; Ke, YY; Liao, JF; Tsai, YC, 2021) |
| " In this paper, we have assessed the impact of citrus pectin and modified citrus pectin on colorectal cancer in rats (Rattus norvegicus F344) to which azoxymethane and DSS were supplied." | 4.02 | Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model. ( Fernández, J; Ferreira-Lazarte, A; Gallego-Lobillo, P; Lombó, F; Moreno, FJ; Villamiel, M; Villar, CJ, 2021) |
| " Susceptibility to cardiac ventricular arrhythmias was significantly reduced in propionate-treated angiotensin II-infused wild-type NMRI mice." | 3.91 | Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage. ( Avery, EG; Balogh, A; Bartolomaeus, H; Dechend, R; Eckardt, KU; Fielitz, J; Forslund, SK; Gollasch, M; Grandoch, M; Haase, N; Hering, L; Höges, S; Homann, S; Kempa, S; Kozhakhmetov, S; Kräker, K; Krannich, A; Kusche-Vihrog, K; Kushugulova, A; Maase, M; Markó, L; Müller, DN; Rump, LC; Stegbauer, J; Tsvetkov, D; Wilck, N; Wundersitz, S; Yakoub, M; Zhumadilov, Z, 2019) |
| " The present study was conducted to find the effect of probiotics and prebiotics in balancing the gut flora in a rodent model of autism linked with a clindamycin-induced altered gut." | 3.91 | Ameliorative effect of probiotics (Lactobacillus paracaseii and Protexin®) and prebiotics (propolis and bee pollen) on clindamycin and propionic acid-induced oxidative stress and altered gut microbiota in a rodent model of autism. ( Aabed, K; Al-Marshoud, M; Al-Mutiri, M; Al-Qahtani, A; Ansary, A; Moubayed, N; Shafi Bhat, R, 2019) |
| "We evaluated the in vivo pharmacological properties of AM803 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, a selective five-lipoxygenase-activating protein (FLAP) inhibitor, using rat and mouse models of acute inflammation." | 3.76 | Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. ( Baccei, CS; Bain, G; Broadhead, AR; Chapman, C; Correa, LD; Darlington, JV; Evans, JF; Hutchinson, JH; King, CD; Lee, C; Lorrain, DS; Prasit, P; Prodanovich, PP; Roppe, J; Santini, AM; Stearns, B; Stock, NS; Zunic, J, 2010) |
| " These acid-induced writhing reactions were significantly attenuated by capsazepine, a VR1 receptor-specific antagonist, but the phenylbenzoquinone-induced one was not, suggesting that the acids but not phenylbenzoquinone activate the VR1 receptor, which is involved in polymodal pain perception." | 3.71 | Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice. ( Ikeda, Y; Naraba, H; Oh-ishi, S; Ueno, A, 2001) |
| "Autism spectrum disorder is a neurodevelopmental disorder marked by repetitive behaviour, challenges in verbal and non-verbal communication, poor socio-emotional health, and cognitive impairment." | 1.72 | Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism. ( Alharbi, M; Alshammari, A; Bhalla, S; Khera, R; Kumar, S; Mehan, S; Sadhu, SS, 2022) |
| "Propionic acid (PPA) is a dietary short chain fatty acid and an enteric bacterial metabolite." | 1.51 | Impaired Spatial Cognition in Adult Rats Treated with Multiple Intracerebroventricular (ICV) Infusions of the Enteric Bacterial Metabolite, Propionic Acid, and Return to Baseline After 1 Week of No Treatment: Contribution to a Rodent Model of ASD. ( Boon, FH; Cain, DP; Foley, KA; MacFabe, DF; Mepham, JR; Ossenkopp, KP, 2019) |
| "Treatment with pioglitazone, significantly attenuated the postnatal propionic acid-induced social impairment, repetitive behavior, hyperactivity, anxiety and low exploratory activity." | 1.51 | A selective peroxisome proliferator-activated receptor-γ agonist benefited propionic acid induced autism-like behavioral phenotypes in rats by attenuation of neuroinflammation and oxidative stress. ( Mirza, R; Sharma, B, 2019) |
| "Group 2 was the rodent model of autism treated with a neurotoxic dose of PPA." | 1.48 | Comparative study on the independent and combined effects of omega-3 and vitamin B12 on phospholipids and phospholipase A2 as phospholipid hydrolyzing enzymes in PPA-treated rats as a model for autistic traits. ( Al-Dbass, A; Al-Mrshoud, M; Al-Mutairi, M; Alfawaz, H; Alnakhli, OM; AlOnazi, M; Bhat, RS; El-Ansary, A; Hasan, IH, 2018) |
| "Propionic acid (PA) is a short chain fatty acid and an important intermediate of cellular metabolism." | 1.38 | Etiology of autistic features: the persisting neurotoxic effects of propionic acid. ( Ben Bacha, A; El-Ansary, AK; Kotb, M, 2012) |
| "Propionic acid (PPA) is a dietary short chain fatty acid and a metabolic end-product of enteric bacteria." | 1.35 | Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism. ( Boon, F; Cain, DP; Jackson, J; Macfabe, DF; Martin, S; Ossenkopp, KP; Shultz, SR; Taylor, R, 2009) |
| "Propionic acid (PPA) is a short chain fatty acid, a metabolic end-product of enteric bacteria in the gut, and a common food preservative." | 1.35 | Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism. ( Cain, DP; MacFabe, DF; Ossenkopp, KP; Scratch, S; Shultz, SR; Taylor, R; Whelan, J, 2008) |
| "Propionic acid (PPA) is a short chain fatty acid and an important intermediate of cellular metabolism." | 1.34 | Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. ( Boon, F; Cain, DP; Franklin, AE; Hoffman, JE; Kavaliers, M; MacFabe, DF; Ossenkopp, KP; Rodriguez-Capote, K; Taylor, AR, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.17) | 18.2507 |
| 2000's | 6 (13.04) | 29.6817 |
| 2010's | 24 (52.17) | 24.3611 |
| 2020's | 15 (32.61) | 2.80 |
| Authors | Studies |
|---|---|
| Hoveyda, HR | 1 |
| Fraser, GL | 1 |
| Zoute, L | 1 |
| Dutheuil, G | 1 |
| Schils, D | 1 |
| Brantis, C | 1 |
| Lapin, A | 1 |
| Parcq, J | 1 |
| Guitard, S | 1 |
| Lenoir, F | 1 |
| Bousmaqui, ME | 1 |
| Rorive, S | 1 |
| Hospied, S | 1 |
| Blanc, S | 1 |
| Bernard, J | 1 |
| Ooms, F | 1 |
| McNelis, JC | 1 |
| Olefsky, JM | 1 |
| Huang, HJ | 1 |
| Chen, JL | 1 |
| Liao, JF | 1 |
| Chen, YH | 1 |
| Chieu, MW | 1 |
| Ke, YY | 1 |
| Hsu, CC | 1 |
| Tsai, YC | 1 |
| Hsieh-Li, HM | 1 |
| Khera, R | 1 |
| Mehan, S | 2 |
| Bhalla, S | 2 |
| Kumar, S | 1 |
| Alshammari, A | 1 |
| Alharbi, M | 1 |
| Sadhu, SS | 1 |
| Xie, Y | 1 |
| Zou, X | 1 |
| Han, J | 1 |
| Zhang, Z | 2 |
| Feng, Z | 1 |
| Ouyang, Q | 1 |
| Hua, S | 1 |
| Liu, Z | 2 |
| Li, C | 1 |
| Cai, Y | 1 |
| Zou, Y | 1 |
| Tang, Y | 1 |
| Jiang, X | 1 |
| Özkul, B | 1 |
| Urfalı, FE | 1 |
| Sever, İH | 1 |
| Bozkurt, MF | 1 |
| Söğüt, İ | 1 |
| Elgörmüş, ÇS | 1 |
| Erdogan, MA | 1 |
| Erbaş, O | 1 |
| Sharma, A | 1 |
| Wu, Z | 1 |
| He, J | 2 |
| Li, J | 1 |
| Zou, H | 1 |
| Tan, X | 1 |
| Wang, Y | 1 |
| Yao, Y | 1 |
| Xiong, W | 1 |
| Zhao, ZH | 1 |
| Xin, FZ | 1 |
| Xue, Y | 1 |
| Hu, Z | 1 |
| Han, Y | 1 |
| Ma, F | 1 |
| Zhou, D | 1 |
| Liu, XL | 1 |
| Cui, A | 1 |
| Liu, Y | 2 |
| Gao, J | 2 |
| Pan, Q | 1 |
| Li, Y | 2 |
| Fan, JG | 1 |
| Aabed, K | 2 |
| Bhat, RS | 4 |
| Al-Dbass, A | 2 |
| Moubayed, N | 2 |
| Algahtani, N | 1 |
| Merghani, NM | 1 |
| Alanazi, A | 1 |
| Zayed, N | 1 |
| El-Ansary, A | 4 |
| Lobzhanidze, G | 1 |
| Japaridze, N | 1 |
| Lordkipanidze, T | 1 |
| Rzayev, F | 1 |
| MacFabe, D | 1 |
| Zhvania, M | 1 |
| Mikami, D | 1 |
| Kobayashi, M | 1 |
| Uwada, J | 1 |
| Yazawa, T | 1 |
| Kamiyama, K | 1 |
| Nishimori, K | 1 |
| Nishikawa, Y | 1 |
| Nishikawa, S | 1 |
| Yokoi, S | 1 |
| Kimura, H | 1 |
| Kimura, I | 1 |
| Taniguchi, T | 1 |
| Iwano, M | 1 |
| Su, X | 1 |
| Yin, X | 1 |
| Yan, X | 1 |
| Zhang, S | 1 |
| Wang, X | 1 |
| Lin, Z | 1 |
| Zhou, X | 1 |
| Wang, Z | 1 |
| Zhang, Q | 1 |
| Ferreira-Lazarte, A | 1 |
| Fernández, J | 1 |
| Gallego-Lobillo, P | 1 |
| Villar, CJ | 1 |
| Lombó, F | 1 |
| Moreno, FJ | 1 |
| Villamiel, M | 1 |
| Mepham, JR | 4 |
| MacFabe, DF | 10 |
| Boon, FH | 2 |
| Foley, KA | 5 |
| Cain, DP | 6 |
| Ossenkopp, KP | 8 |
| Alò, R | 1 |
| Olivito, I | 1 |
| Fazzari, G | 1 |
| Zizza, M | 1 |
| Di Vito, A | 1 |
| Avolio, E | 1 |
| Mandalà, M | 1 |
| Bruno, R | 1 |
| Barni, T | 1 |
| Canonaco, M | 1 |
| Facciolo, RM | 1 |
| Liu, FY | 1 |
| Wen, J | 1 |
| Hou, J | 1 |
| Zhang, SQ | 1 |
| Sun, CB | 1 |
| Zhou, LC | 1 |
| Yin, W | 1 |
| Pang, WL | 1 |
| Wang, C | 1 |
| Ying, Y | 1 |
| Han, SS | 1 |
| Yan, JY | 1 |
| Li, CX | 1 |
| Yuan, JL | 1 |
| Xing, HJ | 1 |
| Yang, ZS | 1 |
| Yang, L | 2 |
| Xie, X | 1 |
| Wu, L | 1 |
| Fan, C | 1 |
| Liang, T | 1 |
| Xi, Y | 1 |
| Yang, S | 1 |
| Li, H | 1 |
| Zhang, J | 1 |
| Ding, Y | 1 |
| Xue, L | 1 |
| Chen, M | 1 |
| Wang, J | 1 |
| Wu, Q | 1 |
| Sharma, AR | 1 |
| Batra, G | 1 |
| Saini, L | 1 |
| Sharma, S | 1 |
| Mishra, A | 1 |
| Singla, R | 1 |
| Singh, A | 1 |
| Singh, RS | 1 |
| Jain, A | 1 |
| Bansal, S | 1 |
| Modi, M | 1 |
| Medhi, B | 1 |
| Chitrala, KN | 1 |
| Guan, H | 1 |
| Singh, NP | 1 |
| Busbee, B | 1 |
| Gandy, A | 1 |
| Mehrpouya-Bahrami, P | 1 |
| Ganewatta, MS | 1 |
| Tang, C | 1 |
| Chatterjee, S | 1 |
| Nagarkatti, P | 1 |
| Nagarkatti, M | 1 |
| Choi, J | 1 |
| Lee, S | 1 |
| Won, J | 1 |
| Jin, Y | 1 |
| Hong, Y | 2 |
| Hur, TY | 1 |
| Kim, JH | 1 |
| Lee, SR | 1 |
| Alfawaz, H | 1 |
| Al-Mutairi, M | 1 |
| Alnakhli, OM | 1 |
| AlOnazi, M | 1 |
| Al-Mrshoud, M | 1 |
| Hasan, IH | 1 |
| Bartolomaeus, H | 1 |
| Balogh, A | 1 |
| Yakoub, M | 1 |
| Homann, S | 1 |
| Markó, L | 1 |
| Höges, S | 1 |
| Tsvetkov, D | 1 |
| Krannich, A | 1 |
| Wundersitz, S | 1 |
| Avery, EG | 1 |
| Haase, N | 1 |
| Kräker, K | 1 |
| Hering, L | 1 |
| Maase, M | 1 |
| Kusche-Vihrog, K | 1 |
| Grandoch, M | 1 |
| Fielitz, J | 1 |
| Kempa, S | 1 |
| Gollasch, M | 1 |
| Zhumadilov, Z | 1 |
| Kozhakhmetov, S | 1 |
| Kushugulova, A | 1 |
| Eckardt, KU | 1 |
| Dechend, R | 1 |
| Rump, LC | 1 |
| Forslund, SK | 1 |
| Müller, DN | 1 |
| Stegbauer, J | 1 |
| Wilck, N | 1 |
| Shams, S | 1 |
| Kavaliers, M | 3 |
| Shafi Bhat, R | 1 |
| Al-Mutiri, M | 1 |
| Al-Marshoud, M | 1 |
| Al-Qahtani, A | 1 |
| Ansary, A | 1 |
| Mirza, R | 1 |
| Sharma, B | 1 |
| Aldbass, AM | 1 |
| Vaz, A | 1 |
| Colín-González, AL | 1 |
| Paz-Loyola, AL | 1 |
| Serratos, I | 1 |
| Seminotti, B | 1 |
| Ribeiro, CA | 1 |
| Leipnitz, G | 1 |
| Souza, DO | 1 |
| Wajner, M | 1 |
| Santamaría, A | 1 |
| Yajima, M | 1 |
| Kimura, S | 1 |
| Karaki, S | 1 |
| Nio-Kobayashi, J | 1 |
| Tsuruta, T | 1 |
| Kuwahara, A | 1 |
| Yajima, T | 2 |
| Iwanaga, T | 1 |
| Al-Salem, HS | 1 |
| Al-Ayadhi, L | 1 |
| Fluegge, K | 1 |
| Shultz, SR | 2 |
| Martin, S | 1 |
| Jackson, J | 1 |
| Taylor, R | 2 |
| Boon, F | 3 |
| Thomas, RH | 2 |
| Tichenoff, LJ | 1 |
| Possmayer, F | 2 |
| Lorrain, DS | 1 |
| Bain, G | 1 |
| Correa, LD | 1 |
| Chapman, C | 1 |
| Broadhead, AR | 1 |
| Santini, AM | 1 |
| Prodanovich, PP | 1 |
| Darlington, JV | 1 |
| Stock, NS | 1 |
| Zunic, J | 1 |
| King, CD | 1 |
| Lee, C | 1 |
| Baccei, CS | 1 |
| Stearns, B | 1 |
| Roppe, J | 1 |
| Hutchinson, JH | 1 |
| Prasit, P | 1 |
| Evans, JF | 1 |
| Cain, NE | 1 |
| Walsh, SP | 1 |
| Severino, A | 1 |
| Zhou, C | 1 |
| Liang, GB | 1 |
| Tan, CP | 1 |
| Cao, J | 1 |
| Eiermann, GJ | 1 |
| Xu, L | 1 |
| Salituro, G | 1 |
| Howard, AD | 1 |
| Mills, SG | 1 |
| El-Ansary, AK | 1 |
| Ben Bacha, A | 1 |
| Kotb, M | 1 |
| Meeking, MM | 1 |
| Tichenoff, L | 1 |
| Liu, S | 1 |
| Bindels, LB | 1 |
| Porporato, P | 1 |
| Dewulf, EM | 1 |
| Verrax, J | 1 |
| Neyrinck, AM | 1 |
| Martin, JC | 1 |
| Scott, KP | 1 |
| Buc Calderon, P | 1 |
| Feron, O | 1 |
| Muccioli, GG | 1 |
| Sonveaux, P | 1 |
| Cani, PD | 1 |
| Delzenne, NM | 1 |
| Ariake, K | 1 |
| Ohkusa, T | 1 |
| Sakurazawa, T | 1 |
| Kumagai, J | 1 |
| Eishi, Y | 1 |
| Hoshi, S | 1 |
| Roh, HY | 1 |
| Jung, IS | 1 |
| Park, JW | 1 |
| Yun, YP | 1 |
| Yi, KY | 1 |
| Yoo, SE | 1 |
| Kwon, SH | 1 |
| Chung, HJ | 1 |
| Shin, HS | 1 |
| Rodriguez-Capote, K | 1 |
| Franklin, AE | 1 |
| Hoffman, JE | 1 |
| Taylor, AR | 1 |
| Scratch, S | 1 |
| Whelan, J | 1 |
| Di Lorenzo, M | 1 |
| Bass, J | 1 |
| Krantis, A | 1 |
| Ikeda, Y | 1 |
| Ueno, A | 1 |
| Naraba, H | 1 |
| Oh-ishi, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mechanisms Linking Dietary Fiber, the Microbiome and Satiety[NCT04611217] | 88 participants (Anticipated) | Interventional | 2021-04-22 | Recruiting | |||
| Prebiotic Therapy to Improve Outcomes of Renal Transplant[NCT04428190] | Early Phase 1 | 60 participants (Anticipated) | Interventional | 2022-02-23 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for propionic acid and Disease Models, Animal
| Article | Year |
|---|---|
Valproic Acid and Propionic Acid Modulated Mechanical Pathways Associated with Autism Spectrum Disorder at Prenatal and Neonatal Exposure.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Food Preservati | 2022 |
45 other studies available for propionic acid and Disease Models, Animal
| Article | Year |
|---|---|
N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; | 2018 |
Lactobacillus plantarum PS128 prevents cognitive dysfunction in Alzheimer's disease mice by modulating propionic acid levels, glycogen synthase kinase 3 beta activity, and gliosis.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Disease Models, Animal; Gliosis; Glycogen Synthas | 2021 |
Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; Janus Kinases; Male; Neuroprotect | 2022 |
Indole-3-propionic acid alleviates ischemic brain injury in a mouse middle cerebral artery occlusion model.
Topics: Animals; Brain Injuries; Chromatography, Liquid; Disease Models, Animal; Humans; Indoles; Infarction | 2022 |
Demonstration of ameliorating effect of vardenafil through its anti-inflammatory and neuroprotective properties in autism spectrum disorder induced by propionic acid on rat model.
Topics: Animals; Anti-Inflammatory Agents; Autism Spectrum Disorder; Disease Models, Animal; Glial Fibrillar | 2022 |
PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism in adult rats.
Topics: Animals; Anthraquinones; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Phosph | 2022 |
Propionic Acid Driven by the
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammatory Bowel Diseases; Lactobacillu | 2023 |
Indole-3-propionic acid inhibits gut dysbiosis and endotoxin leakage to attenuate steatohepatitis in rats.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Dysbiosis; Endotoxins; Gastrointestinal Microbiome; | 2019 |
Bee pollen and propolis improve neuroinflammation and dysbiosis induced by propionic acid, a short chain fatty acid in a rodent model of autism.
Topics: Animals; Autistic Disorder; Brain Chemistry; Cytokines; Disease Models, Animal; Dysbiosis; Inflammat | 2019 |
Behavioural and brain ultrastructural changes following the systemic administration of propionic acid in adolescent male rats. Further development of a rodent model of autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Brain; CA1 Region, Hippocampal; Disease Models, Animal | 2020 |
Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways.
Topics: Adenine; Animals; Cytokines; Disease Models, Animal; Humans; Kidney Tubules, Collecting; Kidney Tubu | 2020 |
Gut Dysbiosis Contributes to the Imbalance of Treg and Th17 Cells in Graves' Disease Patients by Propionic Acid.
Topics: Animals; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Graves Disease; Humans; Met | 2020 |
Behaviour of citrus pectin and modified citrus pectin in an azoxymethane/dextran sodium sulfate (AOM/DSS)-induced rat colorectal carcinogenesis model.
Topics: Acetates; Animals; Azoxymethane; Bifidobacterium; Blood Glucose; Body Weight; Butyrates; Carcinogene | 2021 |
Examining the non-spatial pretraining effect on a water maze spatial learning task in rats treated with multiple intracerebroventricular (ICV) infusions of propionic acid: Contributions to a rodent model of ASD.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Infusions, Intraventric | 2021 |
Correlation of distinct behaviors to the modified expression of cerebral Shank1,3 and BDNF in two autistic animal models.
Topics: Animals; Anxiety; Autistic Disorder; Blotting, Western; Brain-Derived Neurotrophic Factor; Cerebrum; | 2021 |
Gastrodia remodels intestinal microflora to suppress inflammation in mice with early atherosclerosis.
Topics: Acetic Acid; Animals; Aorta; Atherosclerosis; Benzyl Alcohols; Butyric Acid; Disease Models, Animal; | 2021 |
Evaluation of the Cholesterol-Lowering Mechanism of
Topics: Acetic Acid; Animals; Anticholesteremic Agents; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Choles | 2021 |
CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice.
Topics: Animals; Bacteroidetes; Disease Models, Animal; Dysbiosis; Encephalomyelitis, Autoimmune, Experiment | 2017 |
Pathophysiological and neurobehavioral characteristics of a propionic acid-mediated autism-like rat model.
Topics: Aggression; Animals; Autism Spectrum Disorder; Body Weight; Disease Models, Animal; Exploratory Beha | 2018 |
Comparative study on the independent and combined effects of omega-3 and vitamin B12 on phospholipids and phospholipase A2 as phospholipid hydrolyzing enzymes in PPA-treated rats as a model for autistic traits.
Topics: Animals; Autistic Disorder; Cholesterol; Dietary Supplements; Disease Models, Animal; Fatty Acids, O | 2018 |
Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aortic Diseases; Arrhythmias, Cardiac; Arterial P | 2019 |
Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aortic Diseases; Arrhythmias, Cardiac; Arterial P | 2019 |
Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aortic Diseases; Arrhythmias, Cardiac; Arterial P | 2019 |
Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage.
Topics: Angiotensin II; Animals; Anti-Inflammatory Agents; Aortic Diseases; Arrhythmias, Cardiac; Arterial P | 2019 |
Systemic treatment with the enteric bacterial metabolic product propionic acid results in reduction of social behavior in juvenile rats: Contribution to a rodent model of autism spectrum disorder.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Male; Motor Ac | 2019 |
Ameliorative effect of probiotics (Lactobacillus paracaseii and Protexin®) and prebiotics (propolis and bee pollen) on clindamycin and propionic acid-induced oxidative stress and altered gut microbiota in a rodent model of autism.
Topics: Animals; Autistic Disorder; Bacteria; Bees; Clindamycin; Colony Count, Microbial; Cricetinae; Diseas | 2019 |
Impaired Spatial Cognition in Adult Rats Treated with Multiple Intracerebroventricular (ICV) Infusions of the Enteric Bacterial Metabolite, Propionic Acid, and Return to Baseline After 1 Week of No Treatment: Contribution to a Rodent Model of ASD.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Gastrointestinal Microb | 2019 |
A selective peroxisome proliferator-activated receptor-γ agonist benefited propionic acid induced autism-like behavioral phenotypes in rats by attenuation of neuroinflammation and oxidative stress.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Brain; Disease Models, Animal; Explora | 2019 |
Protective and therapeutic potency of N-acetyl-cysteine on propionic acid-induced biochemical autistic features in rats.
Topics: Acetylcysteine; Analysis of Variance; Animals; Autistic Disorder; Brain; Comet Assay; Disease Models | 2013 |
Sexually dimorphic effects of prenatal exposure to propionic acid and lipopolysaccharide on social behavior in neonatal, adolescent, and adult rats: implications for autism spectrum disorders.
Topics: Age Factors; Aging; Animals; Choice Behavior; Discrimination, Psychological; Disease Models, Animal; | 2014 |
Toxic synergism between quinolinic acid and organic acids accumulating in glutaric acidemia type I and in disorders of propionate metabolism in rat brain synaptosomes: Relevance for metabolic acidemias.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Brain; Brain Diseases, Metabolic; Disease Models, Ani | 2015 |
Non-neuronal, but atropine-sensitive ileal contractile responses to short-chain fatty acids: age-dependent desensitization and restoration under inflammatory conditions in mice.
Topics: Acetic Acid; Acetylcholine; Acetylcholinesterase; Age Factors; Animals; Atropine; Choline O-Acetyltr | 2016 |
Therapeutic potency of bee pollen against biochemical autistic features induced through acute and sub-acute neurotoxicity of orally administered propionic acid.
Topics: Animals; Autistic Disorder; Bees; Brain; Disease Models, Animal; Male; Pollen; Propionates; Rats | 2016 |
Propionic acid metabolism, ASD, and vitamin B12: Is there a role for environmental nitrous oxide?
Topics: Animals; Animals, Newborn; Autism Spectrum Disorder; Disease Models, Animal; Environment; Nitrous Ox | 2017 |
Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism.
Topics: 1-Propanol; Analysis of Variance; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; | 2009 |
Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders.
Topics: Animals; Behavior, Animal; Brain; Carnitine; Child; Child Development Disorders, Pervasive; Chromato | 2010 |
Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Carrier Proteins; Chronic Disease; Cysteine; Disease Mo | 2010 |
Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder.
Topics: Animals; Astrocytes; Child; Child Development Disorders, Pervasive; Cognition; Disease Models, Anima | 2011 |
3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists.
Topics: Animals; Cyclization; Disease Models, Animal; Hypoglycemic Agents; Inhibitory Concentration 50; Isle | 2011 |
Etiology of autistic features: the persisting neurotoxic effects of propionic acid.
Topics: Animals; Autistic Disorder; Brain; Disease Models, Animal; Male; Oxidative Stress; Propionates; Rand | 2012 |
The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders.
Topics: Animals; Biomarkers; Brain; Child Development Disorders, Pervasive; Child, Preschool; Disease Models | 2012 |
Gut microbiota-derived propionate reduces cancer cell proliferation in the liver.
Topics: Animals; Cell Proliferation; Diet; Disease Models, Animal; Fatty Acids, Volatile; Female; Fructans; | 2012 |
Roles of mucosal bacteria and succinic acid in colitis caused by dextran sulfate sodium in mice.
Topics: Acetates; Animals; Bacteroidaceae; Bacteroides; Butyric Acid; Carboxylic Acids; Cecum; Colitis; Coli | 2000 |
Cardioprotective effects of [5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Blood Platelets; Cardiotonic Agents; Cell Size; Disease | 2005 |
Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders.
Topics: Animals; Autistic Disorder; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electri | 2007 |
Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism.
Topics: 1-Propanol; Acetic Acid; Aggression; Animals; Autistic Disorder; Brain; Disease Models, Animal; Ente | 2008 |
An intraluminal model of necrotizing enterocolitis in the developing neonatal piglet.
Topics: Aging; Animals; Animals, Newborn; Bacteria; Calcium Gluconate; Caseins; Cecal Diseases; Disease Mode | 1995 |
Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice.
Topics: Acetic Acid; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; B | 2001 |