propionic acid has been researched along with Diabetes Mellitus, Type 2 in 11 studies
propionic acid : A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetic acid, propionic acid, butyric acid, and total SCFA were significantly reduced in T2D patients compared to overweight/obese in the unadjusted model." | 4.12 | Circulating short-chain fatty acids in type 2 diabetic patients and overweight/obese individuals. ( Annuzzi, G; Bozzetto, L; Corrado, A; Costabile, G; Della Pepa, G; Giacco, R; Luongo, D; Rivellese, AA; Salamone, D; Testa, R; Vitale, M, 2022) |
| "Gastrointestinal discomfort is the most common adverse event in metformin treatment for type 2 diabetes." | 3.11 | Gut microbiota is correlated with gastrointestinal adverse events of metformin in patients with type 2 diabetes. ( Bao, Z; Huang, Y; Ji, X; Jiang, C; Lou, X; Sun, J; Tao, X, 2022) |
| "metformin and PA treatment." | 1.72 | Effect of Propionic Acid on Diabetes-Induced Impairment of Unfolded Protein Response Signaling and Astrocyte/Microglia Crosstalk in Rat Ventromedial Nucleus of the Hypothalamus. ( Chaikovsky, YB; Klys, YG; Labudzinskyi, DO; Lisakovska, OO; Natrus, LV; Osadchuk, YS, 2022) |
| " uHTS hit 1 demonstrated an excellent rodent pharmacokinetic profile and selectivity over the related fatty acid receptor GPR40, but only modest GPR120 potency." | 1.43 | Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects. ( Akiyama, TE; Alleyne, C; Bender, K; Crespo, A; Cummings, J; Di Salvo, J; Finley, MF; Geissler, W; Habulihaz, B; Howard, AD; Johnson, E; Kirkland, M; Lei, Y; Leung, D; Lombardo, M; London, C; Madeira, M; Mane, J; Pachanski, M; Plotkin, MA; Pols, J; Powles, MA; Roussel, T; Sinz, CJ; Tata, JR; Trusca, D; Uebele, VN; Ujjainwalla, F, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 6 (54.55) | 2.80 |
| Authors | Studies |
|---|---|
| Natrus, LV | 1 |
| Osadchuk, YS | 1 |
| Lisakovska, OO | 1 |
| Labudzinskyi, DO | 1 |
| Klys, YG | 1 |
| Chaikovsky, YB | 1 |
| Salamone, D | 1 |
| Costabile, G | 1 |
| Corrado, A | 1 |
| Della Pepa, G | 1 |
| Vitale, M | 1 |
| Giacco, R | 1 |
| Luongo, D | 1 |
| Testa, R | 1 |
| Rivellese, AA | 1 |
| Annuzzi, G | 1 |
| Bozzetto, L | 1 |
| Azumi, J | 1 |
| Shimada, Y | 1 |
| Takeda, T | 1 |
| Aso, H | 1 |
| Nakamura, T | 1 |
| Huang, Y | 3 |
| Lou, X | 3 |
| Jiang, C | 3 |
| Ji, X | 3 |
| Tao, X | 3 |
| Sun, J | 3 |
| Bao, Z | 3 |
| Shi, C | 1 |
| Wan, Y | 1 |
| He, A | 1 |
| Wu, X | 1 |
| Shen, X | 1 |
| Zhu, X | 1 |
| Yang, J | 1 |
| Zhou, Y | 1 |
| White, PE | 1 |
| Król, E | 1 |
| Szwengiel, A | 1 |
| Tubacka, M | 1 |
| Szczepankiewicz, D | 1 |
| Staniek, H | 1 |
| Vincent, JB | 1 |
| Krejpcio, Z | 1 |
| Pfeuffer, M | 1 |
| Jaudszus, A | 1 |
| Lombardo, M | 1 |
| Bender, K | 1 |
| London, C | 1 |
| Plotkin, MA | 1 |
| Kirkland, M | 1 |
| Mane, J | 1 |
| Pachanski, M | 1 |
| Geissler, W | 1 |
| Cummings, J | 1 |
| Habulihaz, B | 1 |
| Akiyama, TE | 1 |
| Di Salvo, J | 1 |
| Madeira, M | 1 |
| Pols, J | 1 |
| Powles, MA | 1 |
| Finley, MF | 1 |
| Johnson, E | 1 |
| Roussel, T | 1 |
| Uebele, VN | 1 |
| Crespo, A | 1 |
| Leung, D | 1 |
| Alleyne, C | 1 |
| Trusca, D | 1 |
| Lei, Y | 1 |
| Howard, AD | 1 |
| Ujjainwalla, F | 1 |
| Tata, JR | 1 |
| Sinz, CJ | 1 |
| Singh, S | 1 |
| Sharma, RK | 1 |
| Malhotra, S | 1 |
| Pothuraju, R | 1 |
| Shandilya, UK | 1 |
| Al-Lahham, SH | 1 |
| Peppelenbosch, MP | 1 |
| Roelofsen, H | 2 |
| Vonk, RJ | 1 |
| Venema, K | 2 |
| Al-Lahham, S | 1 |
| Rezaee, F | 1 |
| Weening, D | 1 |
| Hoek, A | 1 |
| Vonk, R | 1 |
2 reviews available for propionic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Pentadecanoic and Heptadecanoic Acids: Multifaceted Odd-Chain Fatty Acids.
Topics: Acyl Coenzyme A; Aging; Cardiovascular Diseases; Citric Acid Cycle; Dairy Products; Diabetes Mellitu | 2016 |
Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms.
Topics: Adipose Tissue; Animals; Child; Child Development Disorders, Pervasive; Colon; Diabetes Mellitus, Ty | 2010 |
1 trial available for propionic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Gut microbiota is correlated with gastrointestinal adverse events of metformin in patients with type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Gastrointestinal Hormones; Gastrointestinal Microbiome; Glucagon | 2022 |
Gut microbiota is correlated with gastrointestinal adverse events of metformin in patients with type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Gastrointestinal Hormones; Gastrointestinal Microbiome; Glucagon | 2022 |
Gut microbiota is correlated with gastrointestinal adverse events of metformin in patients with type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Gastrointestinal Hormones; Gastrointestinal Microbiome; Glucagon | 2022 |
Gut microbiota is correlated with gastrointestinal adverse events of metformin in patients with type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Gastrointestinal Hormones; Gastrointestinal Microbiome; Glucagon | 2022 |
8 other studies available for propionic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Effect of Propionic Acid on Diabetes-Induced Impairment of Unfolded Protein Response Signaling and Astrocyte/Microglia Crosstalk in Rat Ventromedial Nucleus of the Hypothalamus.
Topics: Animals; Astrocytes; Diabetes Mellitus, Type 2; Endoplasmic Reticulum Chaperone BiP; Glucose; Glycat | 2022 |
Circulating short-chain fatty acids in type 2 diabetic patients and overweight/obese individuals.
Topics: Acetic Acid; Butyric Acid; Diabetes Mellitus, Type 2; Fatty Acids, Volatile; Humans; Obesity; Overwe | 2022 |
The Organogermanium Compound 3-(Trihydroxygermyl) Propanoic Acid (THGP) Suppresses Inflammasome Activation Via Complexation with ATP.
Topics: Adenosine Triphosphate; Caspase 1; Cytokines; Diabetes Mellitus, Type 2; Humans; Inflammasomes; Infl | 2022 |
Urinary metabolites associate with the presence of diabetic kidney disease in type 2 diabetes and mediate the effect of inflammation on kidney complication.
Topics: Biomarkers; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Humans; Inflammation; Interleukin-18; | 2023 |
Effects of Bitter Melon and a Chromium Propionate Complex on Symptoms of Insulin Resistance and Type 2 Diabetes in Rat Models.
Topics: Animals; Chromium; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin Resistance; M | 2021 |
Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects.
Topics: Animals; Benzofurans; Blood Glucose; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical; High-T | 2016 |
Lactobacillus rhamnosus NCDC17 ameliorates type-2 diabetes by improving gut function, oxidative stress and inflammation in high-fat-diet fed and streptozotocintreated rats.
Topics: Adiponectin; Animals; Blood Glucose; Cecum; Cultured Milk Products; Diabetes Mellitus, Experimental; | 2017 |
Propionic acid affects immune status and metabolism in adipose tissue from overweight subjects.
Topics: Adipose Tissue; Cells, Cultured; Cytokines; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent A | 2012 |