propionic acid has been researched along with Autism in 26 studies
propionic acid : A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Autism-like rat models were established through intracerebroventricular injections of propionic acid (PPA)." | 8.31 | Luteolin in the Qi Bi Anshen decoction improves propionic acid-induced autism-like behavior in rats by inhibiting LRP1/MMP9. ( Du, Y; Li, J; Li, X; Liu, A; Liu, QQ; Sun, T; Wang, B; Yang, Q; Yu, J; Zhang, M, 2023) |
| "Propionic acid (PPA) was injected intraperitoneally into 20 out of 30 rats for 5 days to establish an autism model." | 8.12 | Therapeutic effect of finasteride through its antiandrogenic and antioxidant role in a propionic acid-induced autism model: Demonstrated by behavioral tests, histological findings and MR spectroscopy. ( Bozkurt, MF; Erbas, O; Ozkul, B; Sever, IH, 2022) |
| " The present study was conducted to find the effect of probiotics and prebiotics in balancing the gut flora in a rodent model of autism linked with a clindamycin-induced altered gut." | 7.91 | Ameliorative effect of probiotics (Lactobacillus paracaseii and Protexin®) and prebiotics (propolis and bee pollen) on clindamycin and propionic acid-induced oxidative stress and altered gut microbiota in a rodent model of autism. ( Aabed, K; Al-Marshoud, M; Al-Mutiri, M; Al-Qahtani, A; Ansary, A; Moubayed, N; Shafi Bhat, R, 2019) |
| "The present study investigated the neuropharmacological role of PPAR-α modulator, fenofibrate in postnatal-propionic acid induced symptomatology related with autism spectrum disorders (ASD) in Wistar rats." | 7.88 | Selective modulator of peroxisome proliferator-activated receptor-α protects propionic acid induced autism-like phenotypes in rats. ( Mirza, R; Sharma, B, 2018) |
| "Autism is a neuropsychiatric disorder characterized by a neurotransmitter imbalance that impairs neurodevelopment processes." | 5.72 | 4-hydroxyisoleucine mediated IGF-1/GLP-1 signalling activation prevents propionic acid-induced autism-like behavioural phenotypes and neurochemical defects in experimental rats. ( Bhalla, S; Mehan, S, 2022) |
| "Propionic acid (PPA) is a short chain fatty acid, a metabolic end-product of enteric bacteria in the gut, and a common food preservative." | 5.35 | Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism. ( Cain, DP; MacFabe, DF; Ossenkopp, KP; Scratch, S; Shultz, SR; Taylor, R; Whelan, J, 2008) |
| "Propionic acid (PPA) is a short chain fatty acid and an important intermediate of cellular metabolism." | 5.34 | Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. ( Boon, F; Cain, DP; Franklin, AE; Hoffman, JE; Kavaliers, M; MacFabe, DF; Ossenkopp, KP; Rodriguez-Capote, K; Taylor, AR, 2007) |
| "Autism-like rat models were established through intracerebroventricular injections of propionic acid (PPA)." | 4.31 | Luteolin in the Qi Bi Anshen decoction improves propionic acid-induced autism-like behavior in rats by inhibiting LRP1/MMP9. ( Du, Y; Li, J; Li, X; Liu, A; Liu, QQ; Sun, T; Wang, B; Yang, Q; Yu, J; Zhang, M, 2023) |
| "Propionic acid (PPA) was injected intraperitoneally into 20 out of 30 rats for 5 days to establish an autism model." | 4.12 | Therapeutic effect of finasteride through its antiandrogenic and antioxidant role in a propionic acid-induced autism model: Demonstrated by behavioral tests, histological findings and MR spectroscopy. ( Bozkurt, MF; Erbas, O; Ozkul, B; Sever, IH, 2022) |
| " The present study was conducted to find the effect of probiotics and prebiotics in balancing the gut flora in a rodent model of autism linked with a clindamycin-induced altered gut." | 3.91 | Ameliorative effect of probiotics (Lactobacillus paracaseii and Protexin®) and prebiotics (propolis and bee pollen) on clindamycin and propionic acid-induced oxidative stress and altered gut microbiota in a rodent model of autism. ( Aabed, K; Al-Marshoud, M; Al-Mutiri, M; Al-Qahtani, A; Ansary, A; Moubayed, N; Shafi Bhat, R, 2019) |
| "The present study investigated the neuropharmacological role of PPAR-α modulator, fenofibrate in postnatal-propionic acid induced symptomatology related with autism spectrum disorders (ASD) in Wistar rats." | 3.88 | Selective modulator of peroxisome proliferator-activated receptor-α protects propionic acid induced autism-like phenotypes in rats. ( Mirza, R; Sharma, B, 2018) |
| "Autism was induced in Sprague-Dawley rats by administering PPA orally (250 mg/kg) for 3 days." | 1.72 | The Efficacy of Fecal Transplantation and Bifidobacterium Supplementation in Ameliorating Propionic Acid-Induced Behavioral and Biochemical Autistic Features in Juvenile Male Rats. ( Aabed, K; Abuaish, S; Abujamel, TS; Al-Otaibi, NM; Algahtani, N; Alotaibi, SM; Alzahrani, SA; Arzoo, S; Bhat, RS; El-Ansary, A; Moubayed, NM, 2022) |
| "Autism is a neuropsychiatric disorder characterized by a neurotransmitter imbalance that impairs neurodevelopment processes." | 1.72 | 4-hydroxyisoleucine mediated IGF-1/GLP-1 signalling activation prevents propionic acid-induced autism-like behavioural phenotypes and neurochemical defects in experimental rats. ( Bhalla, S; Mehan, S, 2022) |
| "Males are more likely to develop autism as a neurodevelopmental disorder than females, but the mechanisms underlying male susceptibility are not fully understood." | 1.62 | The role of sex-differentiated variations in stress hormones, antioxidants, and neuroimmune responses in relation to social interaction impairment in a rodent model of autism. ( Aabed, K; Abuaish, S; Abujamel, TS; Al-Otaibi, NM; Alotaibi, SM; Alzahrani, SA; Arzoo, S; Bhat, RS; El-Ansary, A, 2021) |
| "Group 2 was the rodent model of autism treated with a neurotoxic dose of PPA." | 1.48 | Comparative study on the independent and combined effects of omega-3 and vitamin B12 on phospholipids and phospholipase A2 as phospholipid hydrolyzing enzymes in PPA-treated rats as a model for autistic traits. ( Al-Dbass, A; Al-Mrshoud, M; Al-Mutairi, M; Alfawaz, H; Alnakhli, OM; AlOnazi, M; Bhat, RS; El-Ansary, A; Hasan, IH, 2018) |
| "Eleven Canadian children with autism (3 girls, 8 boys; age 3." | 1.43 | Abnormal fatty acids in Canadian children with autism. ( Jory, J, 2016) |
| "Regressive autism is a devastating disorder affecting children between the ages of 15-30 months." | 1.40 | Model-based hypothesis of gut microbe populations and gut/brain barrier permeabilities in the development of regressive autism. ( Cook, D; Dhurjati, P; Downs, R; Perna, J; Vitelli, A, 2014) |
| "Propionic acid (PA) is a short chain fatty acid and an important intermediate of cellular metabolism." | 1.38 | Etiology of autistic features: the persisting neurotoxic effects of propionic acid. ( Ben Bacha, A; El-Ansary, AK; Kotb, M, 2012) |
| "Propionic acid (PPA) is a short chain fatty acid, a metabolic end-product of enteric bacteria in the gut, and a common food preservative." | 1.35 | Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism. ( Cain, DP; MacFabe, DF; Ossenkopp, KP; Scratch, S; Shultz, SR; Taylor, R; Whelan, J, 2008) |
| "Propionic acid (PPA) is a short chain fatty acid and an important intermediate of cellular metabolism." | 1.34 | Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. ( Boon, F; Cain, DP; Franklin, AE; Hoffman, JE; Kavaliers, M; MacFabe, DF; Ossenkopp, KP; Rodriguez-Capote, K; Taylor, AR, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (7.69) | 29.6817 |
| 2010's | 13 (50.00) | 24.3611 |
| 2020's | 11 (42.31) | 2.80 |
| Authors | Studies |
|---|---|
| Abuaish, S | 3 |
| Al-Otaibi, NM | 3 |
| Aabed, K | 5 |
| Abujamel, TS | 3 |
| Alzahrani, SA | 3 |
| Alotaibi, SM | 3 |
| Bhat, RS | 8 |
| Arzoo, S | 2 |
| Algahtani, N | 3 |
| Moubayed, NM | 1 |
| El-Ansary, A | 10 |
| AlHarbi, RH | 1 |
| Assas, MB | 1 |
| Sahin, K | 1 |
| Orhan, C | 1 |
| Karatoprak, S | 1 |
| Tuzcu, M | 1 |
| Deeh, PBD | 1 |
| Ozercan, IH | 1 |
| Sahin, N | 1 |
| Bozoglan, MY | 1 |
| Sylla, S | 1 |
| Ojalvo, SP | 1 |
| Komorowski, JR | 1 |
| Sever, IH | 1 |
| Ozkul, B | 2 |
| Bozkurt, MF | 1 |
| Erbas, O | 2 |
| Sharma, A | 1 |
| Bhalla, S | 2 |
| Mehan, S | 2 |
| Bagcioglu, E | 1 |
| Solmaz, V | 1 |
| Çakar, B | 1 |
| Uyanikgil, Y | 1 |
| Söğüt, İ | 1 |
| Zhang, M | 1 |
| Yu, J | 1 |
| Liu, A | 1 |
| Liu, QQ | 1 |
| Sun, T | 1 |
| Li, X | 1 |
| Du, Y | 1 |
| Li, J | 1 |
| Wang, B | 1 |
| Yang, Q | 1 |
| Al-Dbass, A | 2 |
| Moubayed, N | 2 |
| Merghani, NM | 1 |
| Alanazi, A | 1 |
| Zayed, N | 1 |
| Lobzhanidze, G | 1 |
| Japaridze, N | 1 |
| Lordkipanidze, T | 1 |
| Rzayev, F | 1 |
| MacFabe, D | 1 |
| Zhvania, M | 1 |
| Alò, R | 1 |
| Olivito, I | 1 |
| Fazzari, G | 1 |
| Zizza, M | 1 |
| Di Vito, A | 1 |
| Avolio, E | 1 |
| Mandalà, M | 1 |
| Bruno, R | 1 |
| Barni, T | 1 |
| Canonaco, M | 1 |
| Facciolo, RM | 1 |
| Alfawaz, H | 2 |
| Al-Mutairi, M | 1 |
| Alnakhli, OM | 1 |
| AlOnazi, M | 1 |
| Al-Mrshoud, M | 1 |
| Hasan, IH | 1 |
| Al-Onazi, M | 1 |
| Bukhari, SI | 1 |
| Binobead, M | 1 |
| Othman, N | 1 |
| Moubayed, NMS | 1 |
| Alzeer, HS | 1 |
| Mirza, R | 1 |
| Sharma, B | 1 |
| Shafi Bhat, R | 1 |
| Al-Mutiri, M | 1 |
| Al-Marshoud, M | 1 |
| Al-Qahtani, A | 1 |
| Ansary, A | 1 |
| Aldbass, AM | 1 |
| Al-Ghamdi, M | 1 |
| Al-Ayadhi, L | 4 |
| Downs, R | 1 |
| Perna, J | 1 |
| Vitelli, A | 1 |
| Cook, D | 1 |
| Dhurjati, P | 1 |
| Alfawaz, HA | 1 |
| El-Ansary, AK | 2 |
| Jory, J | 1 |
| Al-Salem, HS | 1 |
| Ben Bacha, A | 1 |
| Kotb, M | 1 |
| MacFabe, DF | 2 |
| Cain, DP | 2 |
| Rodriguez-Capote, K | 1 |
| Franklin, AE | 1 |
| Hoffman, JE | 1 |
| Boon, F | 1 |
| Taylor, AR | 1 |
| Kavaliers, M | 1 |
| Ossenkopp, KP | 2 |
| Shultz, SR | 1 |
| Scratch, S | 1 |
| Whelan, J | 1 |
| Taylor, R | 1 |
26 other studies available for propionic acid and Autism
| Article | Year |
|---|---|
The Efficacy of Fecal Transplantation and Bifidobacterium Supplementation in Ameliorating Propionic Acid-Induced Behavioral and Biochemical Autistic Features in Juvenile Male Rats.
Topics: Animals; Autistic Disorder; Behavior, Animal; Bifidobacterium; Dietary Supplements; Fecal Microbiota | 2022 |
Different Alterations in Gut Microbiota between
Topics: Animals; Autistic Disorder; Bifidobacterium longum; Fecal Microbiota Transplantation; Feces; Gastroi | 2022 |
Therapeutic Effects of a Novel Form of Biotin on Propionic Acid-Induced Autistic Features in Rats.
Topics: Animals; Autistic Disorder; Biotin; Propionates; Rats; Rats, Wistar | 2022 |
Therapeutic effect of finasteride through its antiandrogenic and antioxidant role in a propionic acid-induced autism model: Demonstrated by behavioral tests, histological findings and MR spectroscopy.
Topics: Animals; Antioxidants; Autistic Disorder; Behavior Rating Scale; Creatine; Finasteride; Lactic Acid; | 2022 |
PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism in adult rats.
Topics: Animals; Anthraquinones; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Phosph | 2022 |
4-hydroxyisoleucine mediated IGF-1/GLP-1 signalling activation prevents propionic acid-induced autism-like behavioural phenotypes and neurochemical defects in experimental rats.
Topics: Animals; Autistic Disorder; Glucagon-Like Peptide 1; Insulin-Like Growth Factor I; Phenotype; Rats | 2022 |
Modafinil Improves Autism-like Behavior in Rats by Reducing Neuroinflammation.
Topics: Animals; Autistic Disorder; Lactates; Male; Modafinil; Neuroinflammatory Diseases; Rats; Rats, Wista | 2023 |
Luteolin in the Qi Bi Anshen decoction improves propionic acid-induced autism-like behavior in rats by inhibiting LRP1/MMP9.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Chromatography, Liquid; Drugs, Chinese Herbal; | 2023 |
Bee pollen and propolis improve neuroinflammation and dysbiosis induced by propionic acid, a short chain fatty acid in a rodent model of autism.
Topics: Animals; Autistic Disorder; Brain Chemistry; Cytokines; Disease Models, Animal; Dysbiosis; Inflammat | 2019 |
Behavioural and brain ultrastructural changes following the systemic administration of propionic acid in adolescent male rats. Further development of a rodent model of autism.
Topics: Animals; Autistic Disorder; Behavior, Animal; Brain; CA1 Region, Hippocampal; Disease Models, Animal | 2020 |
Correlation of distinct behaviors to the modified expression of cerebral Shank1,3 and BDNF in two autistic animal models.
Topics: Animals; Anxiety; Autistic Disorder; Blotting, Western; Brain-Derived Neurotrophic Factor; Cerebrum; | 2021 |
The role of sex-differentiated variations in stress hormones, antioxidants, and neuroimmune responses in relation to social interaction impairment in a rodent model of autism.
Topics: Animals; Antioxidants; Autistic Disorder; Brain Chemistry; Corticosterone; Cytokines; Female; Hormon | 2021 |
Comparative study on the independent and combined effects of omega-3 and vitamin B12 on phospholipids and phospholipase A2 as phospholipid hydrolyzing enzymes in PPA-treated rats as a model for autistic traits.
Topics: Animals; Autistic Disorder; Cholesterol; Dietary Supplements; Disease Models, Animal; Fatty Acids, O | 2018 |
The Independent and Combined Effects of Omega-3 and Vitamin B12 in Ameliorating Propionic Acid Induced Biochemical Features in Juvenile Rats as Rodent Model of Autism.
Topics: Animals; Antioxidants; Autistic Disorder; Brain; Fatty Acids, Omega-3; Gastrointestinal Microbiome; | 2018 |
Selective modulator of peroxisome proliferator-activated receptor-α protects propionic acid induced autism-like phenotypes in rats.
Topics: Animals; Anxiety; Autistic Disorder; Behavior, Animal; Brain; Encephalitis; Female; Fenofibrate; Loc | 2018 |
Ameliorative effect of probiotics (Lactobacillus paracaseii and Protexin®) and prebiotics (propolis and bee pollen) on clindamycin and propionic acid-induced oxidative stress and altered gut microbiota in a rodent model of autism.
Topics: Animals; Autistic Disorder; Bacteria; Bees; Clindamycin; Colony Count, Microbial; Cricetinae; Diseas | 2019 |
Protective and therapeutic potency of N-acetyl-cysteine on propionic acid-induced biochemical autistic features in rats.
Topics: Acetylcysteine; Analysis of Variance; Animals; Autistic Disorder; Brain; Comet Assay; Disease Models | 2013 |
Selected biomarkers as predictive tools in testing efficacy of melatonin and coenzyme Q on propionic acid - induced neurotoxicity in rodent model of autism.
Topics: Animals; Autistic Disorder; Biomarkers; Male; Melatonin; Nerve Tissue Proteins; Neuroprotective Agen | 2014 |
Relative abundance of short chain and polyunsaturated fatty acids in propionic acid-induced autistic features in rat pups as potential markers in autism.
Topics: Animals; Area Under Curve; Autistic Disorder; Biomarkers; Brain; Fatty Acids, Unsaturated; Male; Pro | 2014 |
Model-based hypothesis of gut microbe populations and gut/brain barrier permeabilities in the development of regressive autism.
Topics: Animals; Autistic Disorder; Bacteroides; Blood-Brain Barrier; Child, Preschool; Computer Simulation; | 2014 |
Protective and restorative potency of Vitamin D on persistent biochemical autistic features induced in propionic acid-intoxicated rat pups.
Topics: Animals; Autistic Disorder; Brain; Humans; Male; Propionates; Protective Agents; Rats; Serotonin; Vi | 2014 |
Abnormal fatty acids in Canadian children with autism.
Topics: Arachidonic Acid; Autism Spectrum Disorder; Autistic Disorder; Canada; Case-Control Studies; Child, | 2016 |
Therapeutic potency of bee pollen against biochemical autistic features induced through acute and sub-acute neurotoxicity of orally administered propionic acid.
Topics: Animals; Autistic Disorder; Bees; Brain; Disease Models, Animal; Male; Pollen; Propionates; Rats | 2016 |
Etiology of autistic features: the persisting neurotoxic effects of propionic acid.
Topics: Animals; Autistic Disorder; Brain; Disease Models, Animal; Male; Oxidative Stress; Propionates; Rand | 2012 |
Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders.
Topics: Animals; Autistic Disorder; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electri | 2007 |
Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism.
Topics: 1-Propanol; Acetic Acid; Aggression; Animals; Autistic Disorder; Brain; Disease Models, Animal; Ente | 2008 |