propionic acid has been researched along with Autism Spectrum Disorder in 25 studies
propionic acid : A short-chain saturated fatty acid comprising ethane attached to the carbon of a carboxy group.
Autism Spectrum Disorder: Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Autism-like rat models were established through intracerebroventricular injections of propionic acid (PPA)." | 8.31 | Luteolin in the Qi Bi Anshen decoction improves propionic acid-induced autism-like behavior in rats by inhibiting LRP1/MMP9. ( Du, Y; Li, J; Li, X; Liu, A; Liu, QQ; Sun, T; Wang, B; Yang, Q; Yu, J; Zhang, M, 2023) |
| "Treatment with propionic acid (PPA) has been found to create both brain and behavioral responses in rats that are characteristic of ASD in humans." | 5.91 | The enteric metabolite, propionic acid, impairs social behavior and increases anxiety in a rodent ASD model: Examining sex differences and the influence of the estrous cycle. ( Benitah, KC; Kavaliers, M; Ossenkopp, KP, 2023) |
| "Propionic acid (PPA) is a short-chain fatty acid produced endogenously by gut microbiota and found in foodstuffs and pharmaceutical products as an additive." | 5.72 | Acetyl-L-carnitine and/or liposomal co-enzyme Q10 prevent propionic acid-induced neurotoxicity by modulating oxidative tissue injury, inflammation, and ALDH1A1-RA-RARα signaling in rats. ( Abo-Hamad, A; Alhumaidan, S; Alhusaini, A; Almogren, R; Alsaif, S; Alsultan, E; Hasan, I; Hassanein, E; Mahmoud, A; Mattar, D; Sarawi, W, 2022) |
| "Treatment with pioglitazone, significantly attenuated the postnatal propionic acid-induced social impairment, repetitive behavior, hyperactivity, anxiety and low exploratory activity." | 5.51 | A selective peroxisome proliferator-activated receptor-γ agonist benefited propionic acid induced autism-like behavioral phenotypes in rats by attenuation of neuroinflammation and oxidative stress. ( Mirza, R; Sharma, B, 2019) |
| " Therefore, studying the role of autism etiologies considering sex differences in the propionic acid (PPA) rodent model of autism would build greater understanding of how females are protected from autism spectrum disorder, which may be used as a treatment strategy for males with autism." | 4.31 | Unveiling sex-based differences in developing propionic acid-induced features in mice as a rodent model of ASD. ( Albasher, G; Alonazi, M; Ben Bacha, A; El-Ansary, A; Kamalmaz, N; Khayyat, AIA, 2023) |
| "Autism-like rat models were established through intracerebroventricular injections of propionic acid (PPA)." | 4.31 | Luteolin in the Qi Bi Anshen decoction improves propionic acid-induced autism-like behavior in rats by inhibiting LRP1/MMP9. ( Du, Y; Li, J; Li, X; Liu, A; Liu, QQ; Sun, T; Wang, B; Yang, Q; Yu, J; Zhang, M, 2023) |
| "Treatment with propionic acid (PPA) has been found to create both brain and behavioral responses in rats that are characteristic of ASD in humans." | 1.91 | The enteric metabolite, propionic acid, impairs social behavior and increases anxiety in a rodent ASD model: Examining sex differences and the influence of the estrous cycle. ( Benitah, KC; Kavaliers, M; Ossenkopp, KP, 2023) |
| "Autism spectrum disorder is a neurodevelopmental disorder marked by repetitive behaviour, challenges in verbal and non-verbal communication, poor socio-emotional health, and cognitive impairment." | 1.72 | Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism. ( Alharbi, M; Alshammari, A; Bhalla, S; Khera, R; Kumar, S; Mehan, S; Sadhu, SS, 2022) |
| "Propionic acid (PPA) is a short-chain fatty acid produced endogenously by gut microbiota and found in foodstuffs and pharmaceutical products as an additive." | 1.72 | Acetyl-L-carnitine and/or liposomal co-enzyme Q10 prevent propionic acid-induced neurotoxicity by modulating oxidative tissue injury, inflammation, and ALDH1A1-RA-RARα signaling in rats. ( Abo-Hamad, A; Alhumaidan, S; Alhusaini, A; Almogren, R; Alsaif, S; Alsultan, E; Hasan, I; Hassanein, E; Mahmoud, A; Mattar, D; Sarawi, W, 2022) |
| "Propionic acid (PPA) is a histone deacetylase inhibitor that regulates neuronal plasticity in the brain." | 1.62 | Prenatal exposure to propionic acid induces altered locomotion and reactive astrogliosis in male rats. ( Camacho-Abrego, I; de la Cruz, F; Diaz, A; Flores, G; González-Cano, SI; Morales-Medina, JC, 2021) |
| "Propionic acid (PPA) is a short-chain fatty acid and a by-product of the human gut microbiome." | 1.51 | Systemic Treatment with the Enteric Bacterial Fermentation Product, Propionic Acid, Reduces Acoustic Startle Response Magnitude in Rats in a Dose-Dependent Fashion: Contribution to a Rodent Model of ASD. ( Bishnoi, IR; Kamen, CL; Kavaliers, M; Ossenkopp, KP; Ward, JM; Zevy, DL, 2019) |
| "Propionic acid (PPA) is a dietary short chain fatty acid and an enteric bacterial metabolite." | 1.51 | Impaired Spatial Cognition in Adult Rats Treated with Multiple Intracerebroventricular (ICV) Infusions of the Enteric Bacterial Metabolite, Propionic Acid, and Return to Baseline After 1 Week of No Treatment: Contribution to a Rodent Model of ASD. ( Boon, FH; Cain, DP; Foley, KA; MacFabe, DF; Mepham, JR; Ossenkopp, KP, 2019) |
| "Treatment with pioglitazone, significantly attenuated the postnatal propionic acid-induced social impairment, repetitive behavior, hyperactivity, anxiety and low exploratory activity." | 1.51 | A selective peroxisome proliferator-activated receptor-γ agonist benefited propionic acid induced autism-like behavioral phenotypes in rats by attenuation of neuroinflammation and oxidative stress. ( Mirza, R; Sharma, B, 2019) |
| "Eleven Canadian children with autism (3 girls, 8 boys; age 3." | 1.43 | Abnormal fatty acids in Canadian children with autism. ( Jory, J, 2016) |
| "Propionic acid (PPA) is a ubiquitous short-chain fatty acid, which is a major fermentation product of the enteric microbiome." | 1.43 | Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines. ( Bennuri, SC; Chacko, J; Delhey, L; Frye, RE; Kahler, SG; MacFabe, DF; Melnyk, S; Rose, S; Slattery, JC; Tippett, M; Wynne, R, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (40.00) | 24.3611 |
| 2020's | 15 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Erten, F | 1 |
| Khera, R | 1 |
| Mehan, S | 2 |
| Bhalla, S | 2 |
| Kumar, S | 1 |
| Alshammari, A | 1 |
| Alharbi, M | 1 |
| Sadhu, SS | 1 |
| Özkul, B | 1 |
| Urfalı, FE | 1 |
| Sever, İH | 1 |
| Bozkurt, MF | 1 |
| Söğüt, İ | 1 |
| Elgörmüş, ÇS | 1 |
| Erdogan, MA | 1 |
| Erbaş, O | 1 |
| Sharma, A | 1 |
| Alhusaini, A | 1 |
| Sarawi, W | 1 |
| Mattar, D | 1 |
| Abo-Hamad, A | 1 |
| Almogren, R | 1 |
| Alhumaidan, S | 1 |
| Alsultan, E | 1 |
| Alsaif, S | 1 |
| Hasan, I | 1 |
| Hassanein, E | 1 |
| Mahmoud, A | 1 |
| Kamalmaz, N | 1 |
| Ben Bacha, A | 1 |
| Alonazi, M | 1 |
| Albasher, G | 1 |
| Khayyat, AIA | 1 |
| El-Ansary, A | 1 |
| Zhang, M | 2 |
| Yu, J | 1 |
| Liu, A | 1 |
| Liu, QQ | 1 |
| Sun, T | 1 |
| Li, X | 1 |
| Du, Y | 1 |
| Li, J | 1 |
| Wang, B | 1 |
| Yang, Q | 1 |
| Benitah, KC | 1 |
| Kavaliers, M | 4 |
| Ossenkopp, KP | 6 |
| Wang, T | 1 |
| Chen, B | 1 |
| Luo, M | 1 |
| Xie, L | 1 |
| Lu, M | 1 |
| Lu, X | 1 |
| Zhang, S | 1 |
| Wei, L | 1 |
| Zhou, X | 1 |
| Yao, B | 1 |
| Wang, H | 1 |
| Xu, D | 1 |
| Meeking, MM | 1 |
| MacFabe, DF | 5 |
| Mepham, JR | 3 |
| Foley, KA | 4 |
| Tichenoff, LJ | 1 |
| Boon, FH | 3 |
| Paudel, R | 1 |
| Raj, K | 1 |
| Gupta, YK | 1 |
| Singh, S | 1 |
| Yu, R | 1 |
| Wu, Z | 1 |
| Wang, S | 1 |
| Zhou, G | 1 |
| Li, B | 1 |
| Cain, DP | 2 |
| Sharma, AR | 1 |
| Batra, G | 1 |
| Saini, L | 1 |
| Sharma, S | 1 |
| Mishra, A | 1 |
| Singla, R | 1 |
| Singh, A | 1 |
| Singh, RS | 1 |
| Jain, A | 1 |
| Bansal, S | 1 |
| Modi, M | 1 |
| Medhi, B | 1 |
| González-Cano, SI | 1 |
| Camacho-Abrego, I | 1 |
| Diaz, A | 1 |
| de la Cruz, F | 1 |
| Morales-Medina, JC | 1 |
| Flores, G | 1 |
| Choi, J | 1 |
| Lee, S | 1 |
| Won, J | 1 |
| Jin, Y | 1 |
| Hong, Y | 2 |
| Hur, TY | 1 |
| Kim, JH | 1 |
| Lee, SR | 1 |
| Kamen, CL | 1 |
| Zevy, DL | 1 |
| Ward, JM | 1 |
| Bishnoi, IR | 1 |
| Shams, S | 1 |
| Abdelli, LS | 1 |
| Samsam, A | 1 |
| Naser, SA | 1 |
| Mirza, R | 1 |
| Sharma, B | 1 |
| Jory, J | 1 |
| Frye, RE | 1 |
| Rose, S | 1 |
| Chacko, J | 1 |
| Wynne, R | 1 |
| Bennuri, SC | 1 |
| Slattery, JC | 1 |
| Tippett, M | 1 |
| Delhey, L | 1 |
| Melnyk, S | 1 |
| Kahler, SG | 1 |
| Witters, P | 1 |
| Debbold, E | 1 |
| Crivelly, K | 1 |
| Vande Kerckhove, K | 1 |
| Corthouts, K | 1 |
| Debbold, B | 1 |
| Andersson, H | 1 |
| Vannieuwenborg, L | 1 |
| Geuens, S | 1 |
| Baumgartner, M | 1 |
| Kozicz, T | 1 |
| Settles, L | 1 |
| Morava, E | 1 |
| Fluegge, K | 1 |
1 review available for propionic acid and Autism Spectrum Disorder
| Article | Year |
|---|---|
Valproic Acid and Propionic Acid Modulated Mechanical Pathways Associated with Autism Spectrum Disorder at Prenatal and Neonatal Exposure.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Food Preservati | 2022 |
24 other studies available for propionic acid and Autism Spectrum Disorder
| Article | Year |
|---|---|
Lycopene ameliorates propionic acid-induced autism spectrum disorders by inhibiting inflammation and oxidative stress in rats.
Topics: Animals; Autism Spectrum Disorder; Inflammation; Lycopene; Oxidative Stress; Propionates; Rats | 2021 |
Guggulsterone Mediated JAK/STAT and PPAR-Gamma Modulation Prevents Neurobehavioral and Neurochemical Abnormalities in Propionic Acid-Induced Experimental Model of Autism.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; Janus Kinases; Male; Neuroprotect | 2022 |
Demonstration of ameliorating effect of vardenafil through its anti-inflammatory and neuroprotective properties in autism spectrum disorder induced by propionic acid on rat model.
Topics: Animals; Anti-Inflammatory Agents; Autism Spectrum Disorder; Disease Models, Animal; Glial Fibrillar | 2022 |
PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism in adult rats.
Topics: Animals; Anthraquinones; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Phosph | 2022 |
Acetyl-L-carnitine and/or liposomal co-enzyme Q10 prevent propionic acid-induced neurotoxicity by modulating oxidative tissue injury, inflammation, and ALDH1A1-RA-RARα signaling in rats.
Topics: Acetylcarnitine; Animals; Antioxidants; Autism Spectrum Disorder; Inflammation; Neurotoxicity Syndro | 2022 |
Unveiling sex-based differences in developing propionic acid-induced features in mice as a rodent model of ASD.
Topics: Animals; Autism Spectrum Disorder; Female; Glutamic Acid; Male; Mice; Neuroinflammatory Diseases; Ro | 2023 |
Luteolin in the Qi Bi Anshen decoction improves propionic acid-induced autism-like behavior in rats by inhibiting LRP1/MMP9.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Chromatography, Liquid; Drugs, Chinese Herbal; | 2023 |
The enteric metabolite, propionic acid, impairs social behavior and increases anxiety in a rodent ASD model: Examining sex differences and the influence of the estrous cycle.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Estrous Cycle; Female; Humans; Male; Propionates; Rats; | 2023 |
Microbiota-indole 3-propionic acid-brain axis mediates abnormal synaptic pruning of hippocampal microglia and susceptibility to ASD in IUGR offspring.
Topics: Animals; Autism Spectrum Disorder; Brain; Caffeine; Female; Fetal Growth Retardation; Gastrointestin | 2023 |
Propionic acid induced behavioural effects of relevance to autism spectrum disorder evaluated in the hole board test with rats.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Dose-Response Relationship, Drug; Exploratory B | 2020 |
Oxiracetam and Zinc Ameliorates Autism-Like Symptoms in Propionic Acid Model of Rats.
Topics: Animals; Antioxidants; Autism Spectrum Disorder; Locomotion; Male; Maze Learning; Neuroprotective Ag | 2020 |
Isolation, identification and characterization of propionic acid bacteria associated with autistic spectrum disorder.
Topics: Autism Spectrum Disorder; Bacteria; Child; Enterococcus; Humans; Propionates; RNA, Ribosomal, 16S | 2020 |
Examining the non-spatial pretraining effect on a water maze spatial learning task in rats treated with multiple intracerebroventricular (ICV) infusions of propionic acid: Contributions to a rodent model of ASD.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Infusions, Intraventric | 2021 |
Prenatal exposure to propionic acid induces altered locomotion and reactive astrogliosis in male rats.
Topics: Age Factors; Animals; Autism Spectrum Disorder; Female; Gliosis; Locomotion; Male; Pregnancy; Prenat | 2021 |
Pathophysiological and neurobehavioral characteristics of a propionic acid-mediated autism-like rat model.
Topics: Aggression; Animals; Autism Spectrum Disorder; Body Weight; Disease Models, Animal; Exploratory Beha | 2018 |
Systemic Treatment with the Enteric Bacterial Fermentation Product, Propionic Acid, Reduces Acoustic Startle Response Magnitude in Rats in a Dose-Dependent Fashion: Contribution to a Rodent Model of ASD.
Topics: Acoustic Stimulation; Animals; Autism Spectrum Disorder; Dose-Response Relationship, Drug; Fermentat | 2019 |
Systemic treatment with the enteric bacterial metabolic product propionic acid results in reduction of social behavior in juvenile rats: Contribution to a rodent model of autism spectrum disorder.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Male; Motor Ac | 2019 |
Impaired Spatial Cognition in Adult Rats Treated with Multiple Intracerebroventricular (ICV) Infusions of the Enteric Bacterial Metabolite, Propionic Acid, and Return to Baseline After 1 Week of No Treatment: Contribution to a Rodent Model of ASD.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Gastrointestinal Microb | 2019 |
Propionic Acid Induces Gliosis and Neuro-inflammation through Modulation of PTEN/AKT Pathway in Autism Spectrum Disorder.
Topics: Autism Spectrum Disorder; Biomarkers, Tumor; Butyric Acid; Cell Differentiation; Cell Proliferation; | 2019 |
A selective peroxisome proliferator-activated receptor-γ agonist benefited propionic acid induced autism-like behavioral phenotypes in rats by attenuation of neuroinflammation and oxidative stress.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Brain; Disease Models, Animal; Explora | 2019 |
Abnormal fatty acids in Canadian children with autism.
Topics: Arachidonic Acid; Autism Spectrum Disorder; Autistic Disorder; Canada; Case-Control Studies; Child, | 2016 |
Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines.
Topics: Autism Spectrum Disorder; Case-Control Studies; Cell Line; Child; Gastrointestinal Microbiome; Human | 2016 |
Autism in patients with propionic acidemia.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Child; Female; Humans; Infant, Newborn; Leucin | 2016 |
Propionic acid metabolism, ASD, and vitamin B12: Is there a role for environmental nitrous oxide?
Topics: Animals; Animals, Newborn; Autism Spectrum Disorder; Disease Models, Animal; Environment; Nitrous Ox | 2017 |